Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346466
Yusuke Izawa, T. Osaki, K. Kamiya, S. Fujii, N. Misawa, N. Miki, S. Takeuchi
This paper describes the development of a handheld device for long-term nanopore-based biosensing. Recently, membrane protein reconstituted in bilayer lipid membrane (BLM) has been applied for bio/chemical sensors because membrane protein intrinsically has a superior amplification mechanism. For mobile use of such devices, however, the bilayer requires mechanical robustness. Here, we propose a handheld BLM device aiming for a nanopore-based mobile sensor. BLM is formed at the tip of a glass capillary, which is contained in the solution trapped in a cup-like reservoir. This format achieved (i) formation of a sufficiently robust BLM for mobile use, (ii) solution exchange without rupturing BLM, and (iii) sustaining the small number of nanopores in the bilayer for accurate and long-term sensing. The handheld device successfully detected DNA translocations through the nanopores continuously for 75 minutes using 5 nanopores.
{"title":"Handheld nanopore-based biosensing device","authors":"Yusuke Izawa, T. Osaki, K. Kamiya, S. Fujii, N. Misawa, N. Miki, S. Takeuchi","doi":"10.1109/MEMSYS.2018.8346466","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346466","url":null,"abstract":"This paper describes the development of a handheld device for long-term nanopore-based biosensing. Recently, membrane protein reconstituted in bilayer lipid membrane (BLM) has been applied for bio/chemical sensors because membrane protein intrinsically has a superior amplification mechanism. For mobile use of such devices, however, the bilayer requires mechanical robustness. Here, we propose a handheld BLM device aiming for a nanopore-based mobile sensor. BLM is formed at the tip of a glass capillary, which is contained in the solution trapped in a cup-like reservoir. This format achieved (i) formation of a sufficiently robust BLM for mobile use, (ii) solution exchange without rupturing BLM, and (iii) sustaining the small number of nanopores in the bilayer for accurate and long-term sensing. The handheld device successfully detected DNA translocations through the nanopores continuously for 75 minutes using 5 nanopores.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127614943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346500
Kenei Matsudaira, Hidetoshi Takahashi, K. H. Shoji, Thanh-Vinh Nguyen, T. Tsukagoshi, I. Shimoyama
In this paper, we propose a method to evaluate relationships between twitch forces and static stretch stimuli of iPS cell-derived cardiomyocytes (iPSC-CMs) (force-length relation). The method realized the twitch force measurement of iPSC-CMs statically stretched under the culturing condition. As a result, twitch forces of a few tens of μΝ were measured, and the variation of twitch forces was observed as the static stretch was increased.
{"title":"Load dependency measurement of IPS cell-derived cardiomyocytes' contraction","authors":"Kenei Matsudaira, Hidetoshi Takahashi, K. H. Shoji, Thanh-Vinh Nguyen, T. Tsukagoshi, I. Shimoyama","doi":"10.1109/MEMSYS.2018.8346500","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346500","url":null,"abstract":"In this paper, we propose a method to evaluate relationships between twitch forces and static stretch stimuli of iPS cell-derived cardiomyocytes (iPSC-CMs) (force-length relation). The method realized the twitch force measurement of iPSC-CMs statically stretched under the culturing condition. As a result, twitch forces of a few tens of μΝ were measured, and the variation of twitch forces was observed as the static stretch was increased.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128787151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346607
S. Pyo, Yunsung Kang, Jungwook Choi, Jongbaeg Kim
We demonstrate an improved photoresponse of molybdenum disulfide (MoS2) functionalized with tin oxide (SnO2) and present its application to flexible and transparent photodetector Under illumination by visible light, SnO2-functionalized MoS2 induces the transfer of photo-generated electrons from MoS2 to SnO2 preventing the recombination of photo-excited electron-hole pairs. This photo-induced carrier separation process leads to p-type doping of MoS2, resulting in an increase of current. Accordingly, SnO2-functionalized MoS2 exhibited dramatically improved photoresponse (480%) compared to pristine MoS2. The photodetector fabricated on polyethylene terephthalate (PET) substrate also exhibited high flexibility and transparency, which is advantageous for various applications such as electronic eyes, wearable sensors, and other optoelectronics.
{"title":"Improvement of photoresponse in MoS2 BY SnO2-functionalization and its application to flexible and transparaent photodetector","authors":"S. Pyo, Yunsung Kang, Jungwook Choi, Jongbaeg Kim","doi":"10.1109/MEMSYS.2018.8346607","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346607","url":null,"abstract":"We demonstrate an improved photoresponse of molybdenum disulfide (MoS2) functionalized with tin oxide (SnO2) and present its application to flexible and transparent photodetector Under illumination by visible light, SnO2-functionalized MoS2 induces the transfer of photo-generated electrons from MoS2 to SnO2 preventing the recombination of photo-excited electron-hole pairs. This photo-induced carrier separation process leads to p-type doping of MoS2, resulting in an increase of current. Accordingly, SnO2-functionalized MoS2 exhibited dramatically improved photoresponse (480%) compared to pristine MoS2. The photodetector fabricated on polyethylene terephthalate (PET) substrate also exhibited high flexibility and transparency, which is advantageous for various applications such as electronic eyes, wearable sensors, and other optoelectronics.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126855700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346765
Cheng-Hua Li, Kuan-Wei Chen, Chin-Lung Yang, Che-Hsin Lin, K. Hsieh
A urine testing chip based on the complementary split-ring resonator (CSRR) coupling with a microstrip and the microfluidic channel was developed and demonstrated for determining the water content of the urine. The CSRR is a resonant type of electromagnetic detector, which is sensitivity to the complex permittivity of materials. In addition, the complex permittivity of the tested urine sample is varied with the change of urine composition. Results show that the resonant frequency increased as the urine color became darker due to the decreased water content. Therefore, this microwave technique of the CSRR is proper to distinguish the urine for monitoring the hydration state.
{"title":"A urine testing chip based on the complementary split-ring resonator and microfluidic channel","authors":"Cheng-Hua Li, Kuan-Wei Chen, Chin-Lung Yang, Che-Hsin Lin, K. Hsieh","doi":"10.1109/MEMSYS.2018.8346765","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346765","url":null,"abstract":"A urine testing chip based on the complementary split-ring resonator (CSRR) coupling with a microstrip and the microfluidic channel was developed and demonstrated for determining the water content of the urine. The CSRR is a resonant type of electromagnetic detector, which is sensitivity to the complex permittivity of materials. In addition, the complex permittivity of the tested urine sample is varied with the change of urine composition. Results show that the resonant frequency increased as the urine color became darker due to the decreased water content. Therefore, this microwave technique of the CSRR is proper to distinguish the urine for monitoring the hydration state.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126093399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346565
R. David, N. Miki
We have developed a novel liquid metal based electrodes micro-array for the electrical stimulation of biological tissues with a direct liquid metal — biological tissue contact surface. This work presents for the first time an effort to introduce Gallium based liquid metal components to the field of implantable electrical stimulation systems. The electrical performance and overall integrity of the liquid metal open micro-channel electrodes were fully characterized and analyzed in regard of the properties of the liquid metal used, the surrounding environment, and the stimulation signal. Stable direct contact stimulation electrodes down to a width of 50 μm were successfully produced and tested in-vitro.
{"title":"Liquid metal electrodes micro-array for electrical stimulation via direct contact","authors":"R. David, N. Miki","doi":"10.1109/MEMSYS.2018.8346565","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346565","url":null,"abstract":"We have developed a novel liquid metal based electrodes micro-array for the electrical stimulation of biological tissues with a direct liquid metal — biological tissue contact surface. This work presents for the first time an effort to introduce Gallium based liquid metal components to the field of implantable electrical stimulation systems. The electrical performance and overall integrity of the liquid metal open micro-channel electrodes were fully characterized and analyzed in regard of the properties of the liquid metal used, the surrounding environment, and the stimulation signal. Stable direct contact stimulation electrodes down to a width of 50 μm were successfully produced and tested in-vitro.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126717312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346525
Y. Jia, S. Du, E. Arroyo, A. Seshia
This paper reports for the first time the achievement of autoparametric resonance in a piezoelectric MEMS energy harvester without compromising transducer strain energy optimisation, in order to enhance the efficiency of vibration energy harvesting. The autoparametrically driven energy harvester in excess of a two-fold increase in power output than the same device driven into direct resonance at the same acceleration level, and about an order of magnitude higher in power density normalised to acceleration squared relative to the state-of-the-art.
{"title":"Autoparametric resonance in a piezoelectric MEMS vibration energy harvester","authors":"Y. Jia, S. Du, E. Arroyo, A. Seshia","doi":"10.1109/MEMSYS.2018.8346525","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346525","url":null,"abstract":"This paper reports for the first time the achievement of autoparametric resonance in a piezoelectric MEMS energy harvester without compromising transducer strain energy optimisation, in order to enhance the efficiency of vibration energy harvesting. The autoparametrically driven energy harvester in excess of a two-fold increase in power output than the same device driven into direct resonance at the same acceleration level, and about an order of magnitude higher in power density normalised to acceleration squared relative to the state-of-the-art.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131278741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346512
W. Khan, Y. Jia, F. Madi, A. Weber, Maysam Ghovanloo, Wen Li
We report a free-floating, wirelessly-powered, single channel opto neurostimulator consisting of a reflector-coupled microscale light emitting diode (μLED) and a mm-sized receiver (Rx) coil for untethered optogenetics neuromodulation. An optimized two-coil inductive link delivers over 4 mW instantaneous power at a low operating frequency to continuously drive the μLED while minimizing device invasiveness and tissue exposure to electromagnetic radiation. The reflector-coupled μLED enables significantly enhanced light intensity compared to a bare μLED. The temperature increase of the activated stimulators is <1 °C, well below the safety limit of biomedical implants. In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the rat cortex, using c-Fos as a report of light-evoked neuronal activity.
{"title":"A miniaturized, wirelessly-powered, reflector-coupled single channel opto neurostimulator","authors":"W. Khan, Y. Jia, F. Madi, A. Weber, Maysam Ghovanloo, Wen Li","doi":"10.1109/MEMSYS.2018.8346512","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346512","url":null,"abstract":"We report a free-floating, wirelessly-powered, single channel opto neurostimulator consisting of a reflector-coupled microscale light emitting diode (μLED) and a mm-sized receiver (Rx) coil for untethered optogenetics neuromodulation. An optimized two-coil inductive link delivers over 4 mW instantaneous power at a low operating frequency to continuously drive the μLED while minimizing device invasiveness and tissue exposure to electromagnetic radiation. The reflector-coupled μLED enables significantly enhanced light intensity compared to a bare μLED. The temperature increase of the activated stimulators is <1 °C, well below the safety limit of biomedical implants. In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the rat cortex, using c-Fos as a report of light-evoked neuronal activity.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131186794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346566
Xiao Chuan Ong, Wei-Chen Huang, Ik Soo Kwon, C. Gopinath, Haosheng Wu, L. Fisher, R. Gaunt, C. Bettinger, G. Fedder
This paper reports a method of fabricating peripheral nerve cuff electrodes attached to a sticky hydrogel. The nerve cuff electrode is much more compliant compared to typical cuff electrodes made of polyimide or PDMS and contains adhesion-promoting functional groups that allow for good electrical contact with the nerve without the need for continuous application of pressure on the nerve. A transfer process is used to fabricate the device using poly(acrylic acid) as the sacrificial material that has tunable solubility in aqueous media. This avoids the need for harsh release chemicals that may affect the properties of the hydrogel. The transfer process also allows for electrode contacts that are flush with the surface of the probe and allow intimate contact of with the nerve, as compared with typical recessed electrode contacts. Patterned SU-8 provides a gradual change in Young's modulus from the stiff pad region to the compliant electrode contact region. The measured impedance of the 75 μm radius Pt electrode contacts is ∼100 kΩ. In vivo recordings have been demonstrated using fabricated devices in the dorsal root ganglia of a cat.
{"title":"Ultra-compliant peripheral nerve cuff electrode with hydrogel adhesion","authors":"Xiao Chuan Ong, Wei-Chen Huang, Ik Soo Kwon, C. Gopinath, Haosheng Wu, L. Fisher, R. Gaunt, C. Bettinger, G. Fedder","doi":"10.1109/MEMSYS.2018.8346566","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346566","url":null,"abstract":"This paper reports a method of fabricating peripheral nerve cuff electrodes attached to a sticky hydrogel. The nerve cuff electrode is much more compliant compared to typical cuff electrodes made of polyimide or PDMS and contains adhesion-promoting functional groups that allow for good electrical contact with the nerve without the need for continuous application of pressure on the nerve. A transfer process is used to fabricate the device using poly(acrylic acid) as the sacrificial material that has tunable solubility in aqueous media. This avoids the need for harsh release chemicals that may affect the properties of the hydrogel. The transfer process also allows for electrode contacts that are flush with the surface of the probe and allow intimate contact of with the nerve, as compared with typical recessed electrode contacts. Patterned SU-8 provides a gradual change in Young's modulus from the stiff pad region to the compliant electrode contact region. The measured impedance of the 75 μm radius Pt electrode contacts is ∼100 kΩ. In vivo recordings have been demonstrated using fabricated devices in the dorsal root ganglia of a cat.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125682960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346800
H. Kwon, S. Yoo, J. S. Han, S. M. Lee, U. Hong, J. Hwang, Y. J. Kim
This paper firstly reports a MEMS-based particle size magnifier. By growing nanoparticles to a diameter greater than 1 μm, the proposed device enables optical methods to detect the individual nanoparticles which cannot be seen optically due to their small size. The proposed device shows the potential of realizing a compact and low cost nanoparticle sensor which can measure ultra-low nanoparticle concentration, while the recent MEMS-based particle sensors are only applicable for high particle concentration environment.
{"title":"MEMS-based particle size magnifier for measuring ultra low nanoparticle concentration","authors":"H. Kwon, S. Yoo, J. S. Han, S. M. Lee, U. Hong, J. Hwang, Y. J. Kim","doi":"10.1109/MEMSYS.2018.8346800","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346800","url":null,"abstract":"This paper firstly reports a MEMS-based particle size magnifier. By growing nanoparticles to a diameter greater than 1 μm, the proposed device enables optical methods to detect the individual nanoparticles which cannot be seen optically due to their small size. The proposed device shows the potential of realizing a compact and low cost nanoparticle sensor which can measure ultra-low nanoparticle concentration, while the recent MEMS-based particle sensors are only applicable for high particle concentration environment.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114302227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-04-24DOI: 10.1109/MEMSYS.2018.8346468
Bivas Panigrahi, C. Lu, Neha Ghayal, Chia‐Yuan Chen
This work reports an artificial cilia embedded serpentine microfluidic channel for high throughput zebrafish sperm cell activation. With this proposed device, an average of 74.44 ± 6.07 % of the used zebrafish sperm cells was activated within the first 15 seconds of the experiment. which is at least 20 % superior to the currently other available techniques. The μPIV analysis of the flow zone suggests that the curvilinear microchannel initiates an orbital rotation to the flow field whereas artificial cilia motion establishes a local rotation in the center of the flow field. Collectively. both the rotational motion. harness a uniform mixing within the microchannel which is quintessential towards changing the temporal dynamics of the sperm cells' hence promoting the sperm cell activation.
{"title":"Zebrafish sperm activation through an artificial cilia embedded serpentine microfluidic platform","authors":"Bivas Panigrahi, C. Lu, Neha Ghayal, Chia‐Yuan Chen","doi":"10.1109/MEMSYS.2018.8346468","DOIUrl":"https://doi.org/10.1109/MEMSYS.2018.8346468","url":null,"abstract":"This work reports an artificial cilia embedded serpentine microfluidic channel for high throughput zebrafish sperm cell activation. With this proposed device, an average of 74.44 ± 6.07 % of the used zebrafish sperm cells was activated within the first 15 seconds of the experiment. which is at least 20 % superior to the currently other available techniques. The μPIV analysis of the flow zone suggests that the curvilinear microchannel initiates an orbital rotation to the flow field whereas artificial cilia motion establishes a local rotation in the center of the flow field. Collectively. both the rotational motion. harness a uniform mixing within the microchannel which is quintessential towards changing the temporal dynamics of the sperm cells' hence promoting the sperm cell activation.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116919598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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