Üniversite öğrencilerinde ruh sağlığı problemleri yaygındır. Ancak damgalama, ulaşım, yüksek maliyet, uzmana ulaşamama, uzun bekleme listeleri gibi nedenlerden dolayı üniversite öğrencilerinin psikolojik yardım alma eğilimleri düşüktür. Üniversite öğrencilerinin psikolojik yardım alma engellerini ortadan kaldırabilecek alternatif psikolojik destek müdahaleleri geliştirilmektedir. Teknolojik gelişmelerin psikoloji alanına yansımasının bir sonucu olan internet tabanlı müdahaleler farklı gruplar ve farklı problem alanlarında etkililiği kanıtlanmış müdahalelerdir. Çeşitli kuramsal yaklaşımlara dayalı olarak geliştirilebilen internet tabanlı müdahaleler bilgisayar ya da mobil cihazlar yolu ile sunulmaktadır. İnternet tabanlı müdahaleler yüz yüze sunulan psikolojik yardım sürecine yardımcı bir araç olarak ya da tek başına bir müdahale olarak kullanılabilmektedir. Müdahaleler bir uzman desteği eşliğinde ya da kullanıcının yalnız başına kullanacağı şekilde dizayn edilebilmektedir. Bu derleme çalışmasının ilk bölümünde internet tabanlı müdahalelerin tanımı, kapsamı, türleri, etkililiği, avantajları ile birlikte internet tabanlı müdahalelerde katılım ve erken bırakma, olumsuz/yan etkiler ele alınmıştır. İkinci bölümde internet tabanlı müdahalelerin farklı problem alanları üzerindeki etkililiği üniversite öğrencileri üzerindeki çalışmalar bağlamında değerlendirilmiştir. Son bölümde Türkiye’deki mevcut durum ele alınmış ve bu alanda çalışacak araştırmacılara önerilerde bulunulmuştur.
{"title":"Internet-Based Interventions in Mental Health Services for University Students: A Review","authors":"Ömer Özer, Burak Köksal","doi":"10.20515/otd.1309551","DOIUrl":"https://doi.org/10.20515/otd.1309551","url":null,"abstract":"Üniversite öğrencilerinde ruh sağlığı problemleri yaygındır. Ancak damgalama, ulaşım, yüksek maliyet, uzmana ulaşamama, uzun bekleme listeleri gibi nedenlerden dolayı üniversite öğrencilerinin psikolojik yardım alma eğilimleri düşüktür. Üniversite öğrencilerinin psikolojik yardım alma engellerini ortadan kaldırabilecek alternatif psikolojik destek müdahaleleri geliştirilmektedir. Teknolojik gelişmelerin psikoloji alanına yansımasının bir sonucu olan internet tabanlı müdahaleler farklı gruplar ve farklı problem alanlarında etkililiği kanıtlanmış müdahalelerdir. Çeşitli kuramsal yaklaşımlara dayalı olarak geliştirilebilen internet tabanlı müdahaleler bilgisayar ya da mobil cihazlar yolu ile sunulmaktadır. İnternet tabanlı müdahaleler yüz yüze sunulan psikolojik yardım sürecine yardımcı bir araç olarak ya da tek başına bir müdahale olarak kullanılabilmektedir. Müdahaleler bir uzman desteği eşliğinde ya da kullanıcının yalnız başına kullanacağı şekilde dizayn edilebilmektedir. Bu derleme çalışmasının ilk bölümünde internet tabanlı müdahalelerin tanımı, kapsamı, türleri, etkililiği, avantajları ile birlikte internet tabanlı müdahalelerde katılım ve erken bırakma, olumsuz/yan etkiler ele alınmıştır. İkinci bölümde internet tabanlı müdahalelerin farklı problem alanları üzerindeki etkililiği üniversite öğrencileri üzerindeki çalışmalar bağlamında değerlendirilmiştir. Son bölümde Türkiye’deki mevcut durum ele alınmış ve bu alanda çalışacak araştırmacılara önerilerde bulunulmuştur.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130211406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The benefits of physical activity in promoting health and preventing chronic diseases have been proven; however, inactivity remains a major problem in many countries worldwide. This meta-analysis aimed to evaluate the effectiveness of primary care-based interventions for physical activity promotion. The literature search was carried out on Medline, Cochrane Library, Web of Science, and Scopus databases. Randomized controlled studies performed on adults, included interventions for promoting physical activity, had a follow-up period of at least 12 months, and performed intention-to-treat analysis were reviewed. A total of 16 randomized controlled trials from 7 different countries were included in the meta-analysis (n=8,762). The most common interventions were providing informative materials about physical activity (10 studies), phone calls for support and follow-up (10 studies), and providing an exercise prescription/program for the participants (9 studies). In five studies, participants were given self-monitoring tools to follow up on their own activity levels. Interventions provided low or low-medium increases in the physical activity duration (standardized mean difference [SMD]=0.21, 95.0% CI: 0.15 – 0.27), energy spent on physical activities (SMD=0.14, 95.0% CI: 0.05 – 0.23), and the number of steps (SMD=0.32, 95.0% CI: 0.19 – 0.44). Although interventions aimed to increase the physical activity level showed limited effectiveness, given the strong health benefits of physical activity, promotion programs in this regard need to be integrated into primary health care.
{"title":"Fiziksel Aktiviteyi Teşvik Eden Birinci Basamak Temelli Müdahalelerin Etkililiği: Bir Meta-Analiz Çalışması","authors":"Alican Sarisaltik, N. Lüleci̇, Seyhan Hidiroğlu","doi":"10.20515/otd.1312615","DOIUrl":"https://doi.org/10.20515/otd.1312615","url":null,"abstract":"The benefits of physical activity in promoting health and preventing chronic diseases have been proven; however, inactivity remains a major problem in many countries worldwide. This meta-analysis aimed to evaluate the effectiveness of primary care-based interventions for physical activity promotion. The literature search was carried out on Medline, Cochrane Library, Web of Science, and Scopus databases. Randomized controlled studies performed on adults, included interventions for promoting physical activity, had a follow-up period of at least 12 months, and performed intention-to-treat analysis were reviewed. A total of 16 randomized controlled trials from 7 different countries were included in the meta-analysis (n=8,762). The most common interventions were providing informative materials about physical activity (10 studies), phone calls for support and follow-up (10 studies), and providing an exercise prescription/program for the participants (9 studies). In five studies, participants were given self-monitoring tools to follow up on their own activity levels. Interventions provided low or low-medium increases in the physical activity duration (standardized mean difference [SMD]=0.21, 95.0% CI: 0.15 – 0.27), energy spent on physical activities (SMD=0.14, 95.0% CI: 0.05 – 0.23), and the number of steps (SMD=0.32, 95.0% CI: 0.19 – 0.44). Although interventions aimed to increase the physical activity level showed limited effectiveness, given the strong health benefits of physical activity, promotion programs in this regard need to be integrated into primary health care.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128451684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duygu ARSLAN MEHDİYEV, Demet İlhan Algın, G. Uncu, O. Erdinç
COVID-19 solunum sistemini etkileyen bir hastalık olarak ortaya çıkmış olsa da, artan veriler solunum sistemi ile sınırlı olmadığını, hem merkezi hem de periferik sinir sistemini de etkilediğini göstermektedir. Pandemi olarak ilan edilmesi ve birçok insanı etkilemesi nedeniyle, kronik nörolojik hastalığı olan hastalarda COVID-19 sırasında ve/veya sonrasında hastalığın seyri ve tedavi planı ile ilgili bilgiler giderek önem kazanmaktadır. COVID-19 pozitif olması nedeniyle enfeksiyon hastalıkları servisine yatırılan 42 yaşındaki erkek hasta, solunum ve yutma güçlüğü, dört ekstremitede güçsüzlük şikayeti ile değerlendirildi. Nörolojik muayenesinde dört taraflı kas gücü 3/5 ve dört ekstremitede yaygın hipoestezi saptandı. Derin tendon refleksleri genellikle yoktu. Hastamızın ilk şikayetleri 6 yıl önce başlamış, tipik klinik özellikleri, elektrofizyolojik bulguları sonucunda 2 yıl sonra CIDP tanısı konmuştu. Bu vaka raporunda, COVID-19 ve kronik inflamatuar demiyelinizan polinöropatili (KİDP) bir hastayı paylaşıyoruz ve COVID-19 ile KİDP'nin klinik kötüleşmesini bildirmeyi amaçladık.
{"title":"COVID-19: A Threat of Chronic Inflammatory Demyelinating Polyneuropathy Attack","authors":"Duygu ARSLAN MEHDİYEV, Demet İlhan Algın, G. Uncu, O. Erdinç","doi":"10.20515/otd.1245848","DOIUrl":"https://doi.org/10.20515/otd.1245848","url":null,"abstract":"COVID-19 solunum sistemini etkileyen bir hastalık olarak ortaya çıkmış olsa da, artan veriler solunum sistemi ile sınırlı olmadığını, hem merkezi hem de periferik sinir sistemini de etkilediğini göstermektedir. Pandemi olarak ilan edilmesi ve birçok insanı etkilemesi nedeniyle, kronik nörolojik hastalığı olan hastalarda COVID-19 sırasında ve/veya sonrasında hastalığın seyri ve tedavi planı ile ilgili bilgiler giderek önem kazanmaktadır. COVID-19 pozitif olması nedeniyle enfeksiyon hastalıkları servisine yatırılan 42 yaşındaki erkek hasta, solunum ve yutma güçlüğü, dört ekstremitede güçsüzlük şikayeti ile değerlendirildi. Nörolojik muayenesinde dört taraflı kas gücü 3/5 ve dört ekstremitede yaygın hipoestezi saptandı. Derin tendon refleksleri genellikle yoktu. Hastamızın ilk şikayetleri 6 yıl önce başlamış, tipik klinik özellikleri, elektrofizyolojik bulguları sonucunda 2 yıl sonra CIDP tanısı konmuştu. Bu vaka raporunda, COVID-19 ve kronik inflamatuar demiyelinizan polinöropatili (KİDP) bir hastayı paylaşıyoruz ve COVID-19 ile KİDP'nin klinik kötüleşmesini bildirmeyi amaçladık.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133645329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Yıldız, F. Selvi, C. Bedel, Ökkeş Zortuk, Y. Yavuz
Pulmonary embolism (PE) is a critical disease associated with mortality. Considerable markers related to this disease associated with inflammation have been used to catch thrombus localization. In this study, we wanted to examine the association between the Systemic inflammatory response index (SIRI), Systemic immune-inflammation index (SII) and thrombus localization in patients with PE. Our study consisted of patients diagnosed with PE between January 2020- June 2022. Laboratory parameters of patients diagnosed with PE, especially thrombus localization, thrombus location, SII, and SIRI, were recorded and compared with thrombus localization. One hundred patient with PE who met the inclusion criteria was incorporated in our study. When we grouped the patients according to PE localization, the thrombus was in the main pulmonary vein in 18%, in the lobar region in 51%, and in the distal pulmonary vein in 31% of the patients. In addition, mean SIRI and SII levels were encountered to be higher in patients with main pulmonary localization compared to those with thrombus in both lobar and segmental branches. SIRI has 78% sensitivity, and 72% specificity at the optimum cut-off value; in Level II, it detects thrombus with main pulmonary involvement with 66.7% sensitivity and 79.3% specificity. In patients with PE, high SII and SIRI values can be practical markers in predicting proximal thrombus.
{"title":"Systemic inflammatory response index (SIRI) and Systemic immune-inflammation index (SII) to show Thrombus Localization in Patients with Acute Pulmonary Embolism","authors":"G. Yıldız, F. Selvi, C. Bedel, Ökkeş Zortuk, Y. Yavuz","doi":"10.20515/otd.1276480","DOIUrl":"https://doi.org/10.20515/otd.1276480","url":null,"abstract":"Pulmonary embolism (PE) is a critical disease associated with mortality. Considerable markers related to this disease associated with inflammation have been used to catch thrombus localization. In this study, we wanted to examine the association between the Systemic inflammatory response index (SIRI), Systemic immune-inflammation index (SII) and thrombus localization in patients with PE. Our study consisted of patients diagnosed with PE between January 2020- June 2022. Laboratory parameters of patients diagnosed with PE, especially thrombus localization, thrombus location, SII, and SIRI, were recorded and compared with thrombus localization. One hundred patient with PE who met the inclusion criteria was incorporated in our study. When we grouped the patients according to PE localization, the thrombus was in the main pulmonary vein in 18%, in the lobar region in 51%, and in the distal pulmonary vein in 31% of the patients. In addition, mean SIRI and SII levels were encountered to be higher in patients with main pulmonary localization compared to those with thrombus in both lobar and segmental branches. SIRI has 78% sensitivity, and 72% specificity at the optimum cut-off value; in Level II, it detects thrombus with main pulmonary involvement with 66.7% sensitivity and 79.3% specificity. In patients with PE, high SII and SIRI values can be practical markers in predicting proximal thrombus.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125994359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sepsis, which develops with the triggering of an uncontrolled inflammatory response, causes multiple organ damage and dysfunction. Neuroinflammation occurring in sepsis causes varying degrees of deterioration in the central nervous system. Hexagonal boron nitride (h-BN) nanoparticles composed of boron and nitrogen have potential biomedical applications and are well tolerated by animals. Research has indicated that h-BN nanoparticles exhibit antioxidative characteristics. Although the anti-inflammatory properties of the boron present in them, the effectiveness of h-BN nanoparticles on systemic inflammation or neuroinflammation is unknown. Thus, the aim of this research was to investigate the potential protective benefits of h-BN nanoparticles against inflammation induced by lipopolysaccharide (LPS) in rat brains. An intraperitoneal 5 mg/kg dose of LPS was used to induce sepsis in Sprague Dawley rats. h-BN nanoparticles were given at 50 μg/kg and 100 μg/kg concentrations 24 h before LPS injection. To assess the prophylactic effect of h-BN nanoparticles in sepsis-induced neurodegeneration, besides measuring pro-inflammatory, oxidative stress, and apoptosis markers in brain tissues, the cerebral cortex and hippocampus were also examined histopathologically. Our ELISA results show that h-BN nanoparticles inhibit inflammation in the brain as evidenced by the reduction in LPS-induced increase in tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) levels. h-BN nanoparticles diminished the oxidative stress index and lowered cytochrome c and caspase-3 levels, components of the intrinsic apoptotic pathway. Our histopathological analyzes demonstrated that neuronal and neuroglial damage in the cerebral cortex and hippocampus was also prevented by the treatment of h-BN nanoparticles. These results implicated that h-BN nanoparticles could have a neuroprotective effect against sepsis-induced neurodegeneration through their anti-inflammatory, antioxidant, and anti-apoptotic properties.
{"title":"Hekzagonal Boron Nitrür Nanopartikülleri Septik Sıçan Beyninde Nörodejenerasyonu Önler","authors":"Ayşe ÇAKIR GÜNDOĞDU, Fatih Kar","doi":"10.20515/otd.1297467","DOIUrl":"https://doi.org/10.20515/otd.1297467","url":null,"abstract":"Sepsis, which develops with the triggering of an uncontrolled inflammatory response, causes multiple organ damage and dysfunction. Neuroinflammation occurring in sepsis causes varying degrees of deterioration in the central nervous system. Hexagonal boron nitride (h-BN) nanoparticles composed of boron and nitrogen have potential biomedical applications and are well tolerated by animals. Research has indicated that h-BN nanoparticles exhibit antioxidative characteristics. Although the anti-inflammatory properties of the boron present in them, the effectiveness of h-BN nanoparticles on systemic inflammation or neuroinflammation is unknown. Thus, the aim of this research was to investigate the potential protective benefits of h-BN nanoparticles against inflammation induced by lipopolysaccharide (LPS) in rat brains. An intraperitoneal 5 mg/kg dose of LPS was used to induce sepsis in Sprague Dawley rats. h-BN nanoparticles were given at 50 μg/kg and 100 μg/kg concentrations 24 h before LPS injection. To assess the prophylactic effect of h-BN nanoparticles in sepsis-induced neurodegeneration, besides measuring pro-inflammatory, oxidative stress, and apoptosis markers in brain tissues, the cerebral cortex and hippocampus were also examined histopathologically. Our ELISA results show that h-BN nanoparticles inhibit inflammation in the brain as evidenced by the reduction in LPS-induced increase in tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) levels. h-BN nanoparticles diminished the oxidative stress index and lowered cytochrome c and caspase-3 levels, components of the intrinsic apoptotic pathway. Our histopathological analyzes demonstrated that neuronal and neuroglial damage in the cerebral cortex and hippocampus was also prevented by the treatment of h-BN nanoparticles. These results implicated that h-BN nanoparticles could have a neuroprotective effect against sepsis-induced neurodegeneration through their anti-inflammatory, antioxidant, and anti-apoptotic properties.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"159 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115691560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medikal tedaviye uyumsuzluk, bipolar bozukluk (BB) hastalarında zorlanmanın ve yeti yitiminin yaygın nedenlerinden birisidir. Bu çalışmada, remisyonda olan BB hastalarında tedavi uyum düzeylerinin belirlenmesi, tedaviye uyum üzerine etkili olabilecek faktörlerin çok yönlü olarak tespit edilmesi amaçlanmaktadır. Araştırmaya remisyonda BB tip 1 tanılı 50 hasta dahil edilmiş, sosyodemografik veri formu, Kısa Uluslararası Nöropsikiyatrik Görüşme (MINI Plus 5.0.0), Hamilton Depresyon Derecelendirme Ölçeği (HAM-D), Young Mani Derecelendirme Ölçeği (YMDÖ), Kısa İşlevsellik Değerlendirme Ölçeği (FAST), İçgörünün Üç Bileşenini Değerlendirme Ölçeği, UKU Yan Etki Değerlendirme Ölçeği, Algılanan Sosyal Destek Ölçeği (ASDÖ) ve Tıbbi Tedaviye Uyum Oranı Ölçeği (TTUOÖ) uygulanmıştır. Grupların karşılaştırılmasında; TTUOÖ toplam puanları, cinsiyete (p<0,05), çalışma durumuna (p<0,05), medeni duruma (p<0,05), yakınına göre tedavi uyumu (p<0,05) ve yaygın anksiyete bozukluğu (YAB) eşlik edip etmemesine göre (p<0,05) göre anlamlı fark saptanmıştır. TTUOÖ toplam puanı ile düzenli ilaç kullanım süresi (p<0.01) ve içgörü toplam puanı (p<0,01) arasında aynı yönlü, YMDÖ (p<0.01) ve UKU yan psikolojik yan etkiler altölçeği (UKU1) (p<0,01) ve tüm yan etkiler toplam puanı (UKU toplam) (p<0,05) arasında ters yönlü bir ilişki saptanmıştır. Yapılan Regresyon analizinde; çalışma durumu, eşlik eden YAB ve YMDÖ toplam puanlarının TTUOÖ toplam puanı üzerinde etkili faktörler olduğu bulunmuştur (R=0.64). Araştırmanın bulgularına göre; erkek, evli, düzenli bir işte çalışıyor olmak ve yüksek içgörü düzeyi tedavi uyumunu olumlu yönde etkilerken, yan etkiler ve eşik altı manik belirtiler tedavi uyumunu olumsuz yönde etkilemektedir. Bu sonuçlar doğrultusunda, BB hastalarının iş yaşamının ve sosyal hayatının desteklenmesi, hastalık ve tedavi konularında ayrıntılı bilgilendirilmesi amacıyla psikoeğitime ağırlık verilmesinin önemli olduğu sonuçlarına ulaşılabilmektedir
{"title":"Factors Affecting The Treatment Compliance in Bipolar Disorder Type I","authors":"Nese Burcu Bal, H. H. Özsan","doi":"10.20515/otd.1295324","DOIUrl":"https://doi.org/10.20515/otd.1295324","url":null,"abstract":"Medikal tedaviye uyumsuzluk, bipolar bozukluk (BB) hastalarında zorlanmanın ve yeti yitiminin yaygın nedenlerinden birisidir. Bu çalışmada, remisyonda olan BB hastalarında tedavi uyum düzeylerinin belirlenmesi, tedaviye uyum üzerine etkili olabilecek faktörlerin çok yönlü olarak tespit edilmesi amaçlanmaktadır. Araştırmaya remisyonda BB tip 1 tanılı 50 hasta dahil edilmiş, sosyodemografik veri formu, Kısa Uluslararası Nöropsikiyatrik Görüşme (MINI Plus 5.0.0), Hamilton Depresyon Derecelendirme Ölçeği (HAM-D), Young Mani Derecelendirme Ölçeği (YMDÖ), Kısa İşlevsellik Değerlendirme Ölçeği (FAST), İçgörünün Üç Bileşenini Değerlendirme Ölçeği, UKU Yan Etki Değerlendirme Ölçeği, Algılanan Sosyal Destek Ölçeği (ASDÖ) ve Tıbbi Tedaviye Uyum Oranı Ölçeği (TTUOÖ) uygulanmıştır. Grupların karşılaştırılmasında; TTUOÖ toplam puanları, cinsiyete (p<0,05), çalışma durumuna (p<0,05), medeni duruma (p<0,05), yakınına göre tedavi uyumu (p<0,05) ve yaygın anksiyete bozukluğu (YAB) eşlik edip etmemesine göre (p<0,05) göre anlamlı fark saptanmıştır. TTUOÖ toplam puanı ile düzenli ilaç kullanım süresi (p<0.01) ve içgörü toplam puanı (p<0,01) arasında aynı yönlü, YMDÖ (p<0.01) ve UKU yan psikolojik yan etkiler altölçeği (UKU1) (p<0,01) ve tüm yan etkiler toplam puanı (UKU toplam) (p<0,05) arasında ters yönlü bir ilişki saptanmıştır. Yapılan Regresyon analizinde; çalışma durumu, eşlik eden YAB ve YMDÖ toplam puanlarının TTUOÖ toplam puanı üzerinde etkili faktörler olduğu bulunmuştur (R=0.64). Araştırmanın bulgularına göre; erkek, evli, düzenli bir işte çalışıyor olmak ve yüksek içgörü düzeyi tedavi uyumunu olumlu yönde etkilerken, yan etkiler ve eşik altı manik belirtiler tedavi uyumunu olumsuz yönde etkilemektedir. Bu sonuçlar doğrultusunda, BB hastalarının iş yaşamının ve sosyal hayatının desteklenmesi, hastalık ve tedavi konularında ayrıntılı bilgilendirilmesi amacıyla psikoeğitime ağırlık verilmesinin önemli olduğu sonuçlarına ulaşılabilmektedir","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123289496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasemin SAĞDIÇ KARATEKE, L. Demir, M. Dinçer, B. Yildiz
In this study, the effect of demographic, laboratory and clinicopathological parameters along with neutrophil-lymphocyte ratio (NLR) on prognosis and survival and correlation with other parameters was researched in patients with malignant melanoma (MM) diagnosis. In our study, 107 patients monitored for MM diagnosis in Eskişehir Osmangazi University Medical Oncology clinic from 2010-2017 were retrospectively assessed. Age, gender, LDH level, pathological parameters, BRAF mutation status, neutrophil-lymphocyte ratio (NLR) and the effects of these parameters on overall survival (OS) and disease-free survival (DFS) and correlations with each other were researched. At time of diagnosis, 86% of patients were in the early stage. The dominant types identified were cutaneous MM and nodular MM. Median NLR cut-off value was identified as 1.97. All non-cutaneous MM cases were BRAF negative (p<0.0001). High NLR was associated with advanced stage (p=0.001), advanced age (p=0.008), ulceration presence (p=0.011), and high mitosis count (p=0.05). High NLR (p<0.0001), high LDH level (p=0.04), increased Breslow thickness (p=0.01), increased Clark level (p=0.01), high mitosis count (p=0.02), and lymph node (LN) involvement (p=0.04) were correlated with significantly shorter OS durations. Cox multivariate regression analysis identified the most effective independent parameters on OS were LN involvement (HR: 3.4, p=0.01) and high NLR (HR: 4.6, p=0.04). Nodal involvement was also identified as the most predictive independent parameter for recurrence (HR: 3.2, p=0.03). In addition to classic parameters, NLR appears to be a biomarker which can predict prognosis. Patients with nodal involvement and high NLR values should be monitored more closely in clinics. Data require support with broad-scale studies.
{"title":"Clinicopathological Features of Patients with Malignant Melanoma Diagnosis and Prognostic and Predictive Importance of Neuthrophil-Lymphocyte Ratio","authors":"Yasemin SAĞDIÇ KARATEKE, L. Demir, M. Dinçer, B. Yildiz","doi":"10.20515/otd.1226498","DOIUrl":"https://doi.org/10.20515/otd.1226498","url":null,"abstract":"In this study, the effect of demographic, laboratory and clinicopathological parameters along with neutrophil-lymphocyte ratio (NLR) on prognosis and survival and correlation with other parameters was researched in patients with malignant melanoma (MM) diagnosis. In our study, 107 patients monitored for MM diagnosis in Eskişehir Osmangazi University Medical Oncology clinic from 2010-2017 were retrospectively assessed. Age, gender, LDH level, pathological parameters, BRAF mutation status, neutrophil-lymphocyte ratio (NLR) and the effects of these parameters on overall survival (OS) and disease-free survival (DFS) and correlations with each other were researched. At time of diagnosis, 86% of patients were in the early stage. The dominant types identified were cutaneous MM and nodular MM. Median NLR cut-off value was identified as 1.97. All non-cutaneous MM cases were BRAF negative (p<0.0001). High NLR was associated with advanced stage (p=0.001), advanced age (p=0.008), ulceration presence (p=0.011), and high mitosis count (p=0.05). High NLR (p<0.0001), high LDH level (p=0.04), increased Breslow thickness (p=0.01), increased Clark level (p=0.01), high mitosis count (p=0.02), and lymph node (LN) involvement (p=0.04) were correlated with significantly shorter OS durations. Cox multivariate regression analysis identified the most effective independent parameters on OS were LN involvement (HR: 3.4, p=0.01) and high NLR (HR: 4.6, p=0.04). Nodal involvement was also identified as the most predictive independent parameter for recurrence (HR: 3.2, p=0.03). In addition to classic parameters, NLR appears to be a biomarker which can predict prognosis. Patients with nodal involvement and high NLR values should be monitored more closely in clinics. Data require support with broad-scale studies.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133140950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gamze Taşkın Senol, İ. Kürtül, Abdullah Ray, Gülçin Ahmetoğlu, Y. Secgin, Zülal Öner
Gender determination is the first step for biological identification. With the widespread use of machine learning algorithms (MLA) for diagnosis, the significance of applying them also in gender determination studies has become apparent. This study has therefore aimed at determining gender from the parameters obtained out of magnetic resonance images (MRI) of the cranio-cervical junction and cervical-spinal canal by using MLA. MRI of the craniocervical junction and cervical-spinal canal of 110 men and 110 women were included in this study. The 15 parameters were tested with Decision Tree (DT), Random Forest (RF), Logistic Regression (LR), Linear Discriminant Analysis (LDA), Quadratic Discriminant Analysis (QDA) algorithms. Accuracy (Acc), Specificity (Spe), Sensitivity (Sen), F1 score (F1), Matthews-correlation coefficient (Mcc) values were used as performance criteria. The Acc, Spe, Sen, F1, and Mcc were found to be 1.00 in the LR, LDA, QDA and RF algorithms. The ratios of the Acc, Spe, Sen, and F1 were 0.98, and of the Mcc was 0.96 in the DT algorithm. It was found that the ratio between the SHAP analyzer of the RF algorithm and the belt of the ratio between the arch of the atlas and the anterior-posterior distance of the dens (R3) parameter had a higher contribution to the estimation of gender compared to other parameters. It was concluded that the LDA, QDA, LR, DT and RF algorithms applied to the parameters acquired from the MRI of the craniocervical junction and cervical-spinal canal, could determine the gender with very high accuracy.
{"title":"Determination of Gender By Machine Learning Algorithms, Through Using Craniocervical Junction Parameters and Dimensions of the Cervical Spinal Canal","authors":"Gamze Taşkın Senol, İ. Kürtül, Abdullah Ray, Gülçin Ahmetoğlu, Y. Secgin, Zülal Öner","doi":"10.20515/otd.1291030","DOIUrl":"https://doi.org/10.20515/otd.1291030","url":null,"abstract":"Gender determination is the first step for biological identification. With the widespread use of machine learning algorithms (MLA) for diagnosis, the significance of applying them also in gender determination studies has become apparent. This study has therefore aimed at determining gender from the parameters obtained out of magnetic resonance images (MRI) of the cranio-cervical junction and cervical-spinal canal by using MLA. MRI of the craniocervical junction and cervical-spinal canal of 110 men and 110 women were included in this study. The 15 parameters were tested with Decision Tree (DT), Random Forest (RF), Logistic Regression (LR), Linear Discriminant Analysis (LDA), Quadratic Discriminant Analysis (QDA) algorithms. Accuracy (Acc), Specificity (Spe), Sensitivity (Sen), F1 score (F1), Matthews-correlation coefficient (Mcc) values were used as performance criteria. The Acc, Spe, Sen, F1, and Mcc were found to be 1.00 in the LR, LDA, QDA and RF algorithms. The ratios of the Acc, Spe, Sen, and F1 were 0.98, and of the Mcc was 0.96 in the DT algorithm. It was found that the ratio between the SHAP analyzer of the RF algorithm and the belt of the ratio between the arch of the atlas and the anterior-posterior distance of the dens (R3) parameter had a higher contribution to the estimation of gender compared to other parameters. It was concluded that the LDA, QDA, LR, DT and RF algorithms applied to the parameters acquired from the MRI of the craniocervical junction and cervical-spinal canal, could determine the gender with very high accuracy.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125086925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The understanding of a written text is directly related to the readability level of that text. Readability can be measured objectively using specific formulas. In this study, we aimed to determine the readability level of the drug package inserts of antidepressant drugs. A total of 51 drug package inserts were grouped according to antidepressant types. Title and drug license information was removed from the texts for standardization. These were evaluated using the Ateşman, Bezirci–Yılmaz and Çetinkaya–Uzun readability formulas, applicable to Turkish texts. The average Ateşman readability score was determined as 71.4. Accordingly, it was seen that the drug package inserts require a grade 7-8 of education for readability. The readability level of the Bezirci-Yılmaz formula was, similarly, of grade 7-8 (primary education) level. The Çetinkaya-Uzun readability score was calculated as 45.4 and an 8-9th grade level was determined. It was ascertained that the drug package inserts were readable at the secondary education (7th-9th grade) level on average. Considering the average education level in Turkey, it was established that the readability level was therefore high. We believe that writing the drug package inserts based on the average education level will increase readability and therefore intelligibility.
{"title":"Psikiyatride Yaygın Olarak Kullanılan Antidepresan İlaç Prospektüslerinin Okunabilirliğinin Değerlendirilmesi","authors":"Merve Akkuş","doi":"10.20515/otd.1260211","DOIUrl":"https://doi.org/10.20515/otd.1260211","url":null,"abstract":"The understanding of a written text is directly related to the readability level of that text. Readability can be measured objectively using specific formulas. In this study, we aimed to determine the readability level of the drug package inserts of antidepressant drugs. A total of 51 drug package inserts were grouped according to antidepressant types. Title and drug license information was removed from the texts for standardization. These were evaluated using the Ateşman, Bezirci–Yılmaz and Çetinkaya–Uzun readability formulas, applicable to Turkish texts. The average Ateşman readability score was determined as 71.4. Accordingly, it was seen that the drug package inserts require a grade 7-8 of education for readability. The readability level of the Bezirci-Yılmaz formula was, similarly, of grade 7-8 (primary education) level. The Çetinkaya-Uzun readability score was calculated as 45.4 and an 8-9th grade level was determined. It was ascertained that the drug package inserts were readable at the secondary education (7th-9th grade) level on average. Considering the average education level in Turkey, it was established that the readability level was therefore high. We believe that writing the drug package inserts based on the average education level will increase readability and therefore intelligibility.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"184 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114156094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gurkan Bozan, Eylem Kiral, Mahmut Can Kizil, Yalçın Kara, M. Arda, Huseyin ILHAN, TURKEY, Çiğdem Öztunali, Tercan Us, Ömer Kılıç, Ener Çağrı Dinleyici
Objective: Pleural effusion is a complication of bacterial pneumonia that is of particular importance because of its significant morbidity and mortality in children. The aim of this study was to investigate the clinical and etiological profile of pleural effusion in children. Materials-Methods: Medical records of children with pleural effusion who were followed up at Eskişehir Osmangazi University Faculty of Medicine between January 2012 and December 2022 were retrospectively evaluated. Clinical and etiological features, laboratory and radiological results, and treatment regimens of were noted. Results: Medical records of 59 children (55.9% girls) aged between 7 to 216 months (median 100 months) have been noted. The etiology of pleural effusion was parapneumonic effusion in 37 children (62.7%), tuberculous pleurisy in eight children (13.5%). The most common bacterial pathogens were Streptococcus pyogenes, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae and Haemophilus influenzae. In the post-pandemic period, while cases of tuberculous pleurisy are decreasing, there is an increase in pleural effusions due to Streptococcus pyogenes. Medical treatment alone was given in 39% of cases, tube thoracostomy in 55%, thoracotomy and decortication in 18.6%. A 45.8% of children required pediatric intensive care unit stay. The median hospital stay was 12 days. Conclusion: Parapneumonic effusions due to bacterial agents are the most common cause of pediatric pleural effusions. After the COVID-19 pandemic, while cases of tuberculosis pleurisy are decreasing, there is an increase in Streptococcus pyogenes-induced pleural effusion/empyema.
{"title":"Plevral Efüzyonla Hastaneye Yatan Çocukların Epidemiyolojik Ve Klinik Profili: Tek Merkez Deneyimi 2012-2022","authors":"Gurkan Bozan, Eylem Kiral, Mahmut Can Kizil, Yalçın Kara, M. Arda, Huseyin ILHAN, TURKEY, Çiğdem Öztunali, Tercan Us, Ömer Kılıç, Ener Çağrı Dinleyici","doi":"10.20515/otd.1320461","DOIUrl":"https://doi.org/10.20515/otd.1320461","url":null,"abstract":"Objective: Pleural effusion is a complication of bacterial pneumonia that is of particular importance because of its significant morbidity and mortality in children. The aim of this study was to investigate the clinical and etiological profile of pleural effusion in children. \u0000Materials-Methods: Medical records of children with pleural effusion who were followed up at Eskişehir Osmangazi University Faculty of Medicine between January 2012 and December 2022 were retrospectively evaluated. Clinical and etiological features, laboratory and radiological results, and treatment regimens of were noted. \u0000Results: Medical records of 59 children (55.9% girls) aged between 7 to 216 months (median 100 months) have been noted. The etiology of pleural effusion was parapneumonic effusion in 37 children (62.7%), tuberculous pleurisy in eight children (13.5%). The most common bacterial pathogens were Streptococcus pyogenes, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae and Haemophilus influenzae. In the post-pandemic period, while cases of tuberculous pleurisy are decreasing, there is an increase in pleural effusions due to Streptococcus pyogenes. Medical treatment alone was given in 39% of cases, tube thoracostomy in 55%, thoracotomy and decortication in 18.6%. A 45.8% of children required pediatric intensive care unit stay. The median hospital stay was 12 days. \u0000Conclusion: Parapneumonic effusions due to bacterial agents are the most common cause of pediatric pleural effusions. After the COVID-19 pandemic, while cases of tuberculosis pleurisy are decreasing, there is an increase in Streptococcus pyogenes-induced pleural effusion/empyema.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133061732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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