Objective: To evaluate the effect of generalized joint hypermobility (GJH) on health-related physical fitness. Participants: Female university students between the ages of 18-23. Methods: Cardiorespiratory fitness ((maximal cycling ergometer tests, six-minute walking tests (6MW)), respiratory function tests, respiratory muscle strength (maximal inspiratory and expiratory pressure), body composition (bioelectrical impedance analyses), flexibility (sit and reach tests (SRT), muscle strength and endurance (isometric and isokinetic tests) were evaluated for health-related physical fitness. Results: The mean VO2max (23.6 vs. 21.8, p=.049), MET (6.7 vs. 6.3, p=0.049), W/kg (1.6 vs. 1.5, p=0.035), and SRT scores (23.3 vs. 18.7, p=0.016) were higher in 39 students with asymptomatic GJH compared to 42 non-GJH students. No significant differences found between groups for 6MW, FVC, FEV1, MIP, MEP, body composition, muscle strength, and endurance (p>.05). Conclusion: Females with generalized joint hypermobility have the same or even higher levels of physical fitness capacity as those without the hypermobility.
目的：评估全身关节活动过多症（GJH）对健康相关体能的影响：评估全身关节活动过度症（GJH）对健康相关体能的影响。参与者年龄在 18-23 岁之间的女大学生。研究方法对心肺功能（最大自行车测力计测试、六分钟步行测试（6MW））、呼吸功能测试、呼吸肌力量（最大吸气和呼气压力）、身体成分（生物电阻抗分析）、柔韧性（坐位和伸展测试（SRT））、肌肉力量和耐力（等长和等动测试）进行健康相关体能评估。结果显示39 名无症状 GJH 学生的平均 VO2max（23.6 vs. 21.8，p=0.049）、MET（6.7 vs. 6.3，p=0.049）、W/kg（1.6 vs. 1.5，p=0.035）和 SRT 分数（23.3 vs. 18.7，p=0.016）均高于 42 名非 GJH 学生。各组之间在 6MW、FVC、FEV1、MIP、MEP、身体成分、肌肉力量和耐力方面没有发现明显差异（P>.05）。结论患有全身关节活动过度症的女性与没有关节活动过度症的女性具有相同甚至更高的体能能力水平。
{"title":"The health-related physical fitness of university female students with and without generalized joint hypermobility: A case-control study","authors":"Hande Özdemir, Filiz Tuna, D. Demirbağ Kabayel","doi":"10.20515/otd.1463720","DOIUrl":"https://doi.org/10.20515/otd.1463720","url":null,"abstract":"Objective: To evaluate the effect of generalized joint hypermobility (GJH) on health-related physical fitness. \u0000Participants: Female university students between the ages of 18-23. \u0000Methods: Cardiorespiratory fitness ((maximal cycling ergometer tests, six-minute walking tests (6MW)), respiratory function tests, respiratory muscle strength (maximal inspiratory and expiratory pressure), body composition (bioelectrical impedance analyses), flexibility (sit and reach tests (SRT), muscle strength and endurance (isometric and isokinetic tests) were evaluated for health-related physical fitness. \u0000Results: The mean VO2max (23.6 vs. 21.8, p=.049), MET (6.7 vs. 6.3, p=0.049), W/kg (1.6 vs. 1.5, p=0.035), and SRT scores (23.3 vs. 18.7, p=0.016) were higher in 39 students with asymptomatic GJH compared to 42 non-GJH students. No significant differences found between groups for 6MW, FVC, FEV1, MIP, MEP, body composition, muscle strength, and endurance (p>.05). \u0000Conclusion: Females with generalized joint hypermobility have the same or even higher levels of physical fitness capacity as those without the hypermobility.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141128141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Babur, Özlem Barutçu, Esra Tufan, Hatice Saray, Cem Süer
Giriş: İnsülin, pankreatik beta hücrelerinden salgılanan glukoz homeostazisinin sürdürülmesinde gerekli bir hormondur. Periferik etkileri ayrıntılı bir şekilde açığa çıkarılmasına rağmen kognitif fonksiyonlar üzerine etkisi belirsizdir. Bu çalışmada insülinin hipokampal uzun dönemli baskılanma üzerine etkisi araştırılmıştır. Metot: Bu çalışmada ağırlıkları 200-300 gr arasında değişen 24 adet Wistar erkek sıçan kullanılmıştır. Sıçanlar; Serum fizyolojik infüze edilen grup (SF, n=6), insülin infüze edilen grup (İnsülin, n=6), NT157 infüze edilen grup (NT157, n=6) ve insülin ile birlikte NT157 infüze edilen grup (İnsülin+NT157, n=6) olmak üzere dört gruba ayrılmıştır. Uzun dönemli baskılanma perforant yola uygulanan 1 Hz 900 adet düşük frekanslı uyarı (DFU) ile indüklenmiştir. Dentat girus granül hücrelerinden elde edilen alan potansiyellerinden eksitatör postsinaptik potansiyel (EPSP) eğimi ve populasyon spike (PS) genlikleri kaydedilmiştir. Deney bitiminde çıkarılan uyarılmış hipokampüslerde PI3K, AKT, GSK3-b, IRS ve MAPT gen ekspresyonu düzeyleri PCR yöntemi ile ölçülmüştür. Bulgular: Perforan yolun 1 Hz ile uyarımı sonrası PS değerleri insülin infüze edilen grupta SF infüze edilen gruba karşı istatistiksel olarak anlamlı düşüş göstermiştir (p
{"title":"İnsülinin Sinaptik Plastisitedeki Rolü: Uzun Dönemli Baskılanma","authors":"E. Babur, Özlem Barutçu, Esra Tufan, Hatice Saray, Cem Süer","doi":"10.20515/otd.1400449","DOIUrl":"https://doi.org/10.20515/otd.1400449","url":null,"abstract":"Giriş: İnsülin, pankreatik beta hücrelerinden salgılanan glukoz homeostazisinin sürdürülmesinde gerekli bir hormondur. Periferik etkileri ayrıntılı bir şekilde açığa çıkarılmasına rağmen kognitif fonksiyonlar üzerine etkisi belirsizdir. Bu çalışmada insülinin hipokampal uzun dönemli baskılanma üzerine etkisi araştırılmıştır. \u0000Metot: Bu çalışmada ağırlıkları 200-300 gr arasında değişen 24 adet Wistar erkek sıçan kullanılmıştır. Sıçanlar; Serum fizyolojik infüze edilen grup (SF, n=6), insülin infüze edilen grup (İnsülin, n=6), NT157 infüze edilen grup (NT157, n=6) ve insülin ile birlikte NT157 infüze edilen grup (İnsülin+NT157, n=6) olmak üzere dört gruba ayrılmıştır. Uzun dönemli baskılanma perforant yola uygulanan 1 Hz 900 adet düşük frekanslı uyarı (DFU) ile indüklenmiştir. Dentat girus granül hücrelerinden elde edilen alan potansiyellerinden eksitatör postsinaptik potansiyel (EPSP) eğimi ve populasyon spike (PS) genlikleri kaydedilmiştir. Deney bitiminde çıkarılan uyarılmış hipokampüslerde PI3K, AKT, GSK3-b, IRS ve MAPT gen ekspresyonu düzeyleri PCR yöntemi ile ölçülmüştür. \u0000Bulgular: Perforan yolun 1 Hz ile uyarımı sonrası PS değerleri insülin infüze edilen grupta SF infüze edilen gruba karşı istatistiksel olarak anlamlı düşüş göstermiştir (p","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":" 52","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141128282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Periferik fasiyal sinir paralizisi (PFP) çocuk hastalıkları ve çocuk nöroloji polikliniklerinde sıkça karşımıza çıkmaktadır. Fizik muayene esnasında fazla kilolu oldukları gözlemlenen PFP hastalarından yola çıkılarak çocuklarda PFP ve aşırı kiloluluk ve obezite ilişkisinin araştırılması amaçlanmıştır. Çalışmaya 1 Nisan 2021 ve 31 Ekim 2022 tarihleri arasında tek merkezden Uluslararası Hastalık Sınıflandırması (ICD)-10 birincil ve ikincil G51.0 (fasiyal sinir paralizisi) tanısı alan 42 hasta dahil edildi. Hastaların yaş, cinsiyet, hastalığın ortaya çıkışından hastaneye başvuruya kadar geçen süre, başvuru sırasındaki House-Brackmann (HB) skoru ve PFP derecesi, 4. Hafta HB skoru, PFP etiyolojisi, vücut kitle indeksi (VKİ), aşırı kilo ve obezite dahil ilişkili hastalıkların varlığı retrospektif olarak kaydedildi. 18 yaşı doldurmuş hastalar, santral FP'li hastaları, verilerde eksiklikleri olan hastalar çalışma dışı bırakıldı. Verileri tam olan 30 PFP’li çocuk hasta çalışmaya dahil edildi ve bunların 22 tanesi idiyopatik olarak sınıflandırıldı. İdiyopatik grupta ve tüm kohortta PFP olan hastaların sırasıyla %73 (n=22) ve %70(n=18) 'inin VKİ'si 90. persentilin üzerindeydi. Her iki grupta kız cinsiyet daha yüksek görülse de cinsiyetler arasında anlamlı bir fark saptanmadı. Yüksek VKİ, aşırı kilolu ve obez hasta grubunda (VKİ >90. persentil; olasılık oranı [OR], 8; %95 güven aralığı [GA], 1,25 ila51,13; p < 0,05) istatistiksel olarak artmış Bell paralizisi olasılığı ile ilişkilendirildi. Aynı zamanda VKI>25kg/m2 olan idiyopatik PFP olan grupta ek hastalık oranı %53 (n=5 hipertansiyon, n=3 hipotiroidi), idiyopatik olmayan gruba göre daha yüksek saptandı, ancak istatistiksel olarak anlamlı fark saptanmadı. Bu sonuçlar aşırı kilo ve obezitenin çocuklarda artmış Bell paralizisi riski ile ilişkili olabileceğinin altını çizmektedir.
{"title":"Çocuklarda Periferik Fasiyal Sinir Paralizisi ve Obezite: Tesadüften Fazlası mı?","authors":"Pınar Ozbudak","doi":"10.20515/otd.1410994","DOIUrl":"https://doi.org/10.20515/otd.1410994","url":null,"abstract":"Periferik fasiyal sinir paralizisi (PFP) çocuk hastalıkları ve çocuk nöroloji polikliniklerinde sıkça karşımıza çıkmaktadır. Fizik muayene esnasında fazla kilolu oldukları gözlemlenen PFP hastalarından yola çıkılarak çocuklarda PFP ve aşırı kiloluluk ve obezite ilişkisinin araştırılması amaçlanmıştır. Çalışmaya 1 Nisan 2021 ve 31 Ekim 2022 tarihleri arasında tek merkezden Uluslararası Hastalık Sınıflandırması (ICD)-10 birincil ve ikincil G51.0 (fasiyal sinir paralizisi) tanısı alan 42 hasta dahil edildi. Hastaların yaş, cinsiyet, hastalığın ortaya çıkışından hastaneye başvuruya kadar geçen süre, başvuru sırasındaki House-Brackmann (HB) skoru ve PFP derecesi, 4. Hafta HB skoru, PFP etiyolojisi, vücut kitle indeksi (VKİ), aşırı kilo ve obezite dahil ilişkili hastalıkların varlığı retrospektif olarak kaydedildi. 18 yaşı doldurmuş hastalar, santral FP'li hastaları, verilerde eksiklikleri olan hastalar çalışma dışı bırakıldı. Verileri tam olan 30 PFP’li çocuk hasta çalışmaya dahil edildi ve bunların 22 tanesi idiyopatik olarak sınıflandırıldı. İdiyopatik grupta ve tüm kohortta PFP olan hastaların sırasıyla %73 (n=22) ve %70(n=18) 'inin VKİ'si 90. persentilin üzerindeydi. Her iki grupta kız cinsiyet daha yüksek görülse de cinsiyetler arasında anlamlı bir fark saptanmadı. Yüksek VKİ, aşırı kilolu ve obez hasta grubunda (VKİ >90. persentil; olasılık oranı [OR], 8; %95 güven aralığı [GA], 1,25 ila51,13; p < 0,05) istatistiksel olarak artmış Bell paralizisi olasılığı ile ilişkilendirildi. Aynı zamanda VKI>25kg/m2 olan idiyopatik PFP olan grupta ek hastalık oranı %53 (n=5 hipertansiyon, n=3 hipotiroidi), idiyopatik olmayan gruba göre daha yüksek saptandı, ancak istatistiksel olarak anlamlı fark saptanmadı. Bu sonuçlar aşırı kilo ve obezitenin çocuklarda artmış Bell paralizisi riski ile ilişkili olabileceğinin altını çizmektedir.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"53 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Utku Aygüneş, B. Karagün, H. I. Sasmaz, A. Antmen, Gökhan Tümgör
Acute graft-versus-host disease is a common complication of allogeneic hematopoietic stem cell transplantation and is a major cause of morbidity and mortality. Systemic steroid therapy is the first-line treatment for acute graft-versus-host disease, although about half of patients will become refractory to treatment. We aimed to evaluate treatment options by reviewing available alternatives for patients with steroid-refractory acute graft-versus-host disease by comparing data from recently published studies. We retrospectively studied the safety and efficacy of treatment in 22 children with steroid‐dependent/refractory acute GVHD between the years 2010 and 2023. Seven (31.8%) out of 22 patients with acute graft-versus-host disease were still alive. The seven surviving patients have been followed for an average of 1141 (±403) days. 15 non-responders with grade III/IV acute graft-versus-host disease died from causes associated with acute graft-versus-host disease and/or other conditions. Among 15 patients who died, the number of patients who received all three treatments, MSC, ECP and infliximab, was 5 (33%). The most common cause of death was infection (8 cases in 15 patients, 53.3%). Other causes of death were gastrointestinal hemorrhages (n=5, 33.3%), and intracranial hemorrhages (n=2, 13.3%). When factors causing morbidity were evaluated, it was observed that three patients developed posterior reversible encephalopathy syndrome, two patients developed hepatic veno-occlusive disease, and one patient developed hypertension. The estimated probability of survival after 1 year was 31.8%, and the median survival was 655 days. We believe that it would be crucial to show the safety and efficacy of novel treatments in comprehensive, randomized clinical trials.
{"title":"The Treatment of Steroid-Refractory Severe Gastrointestinal Acute Graft-Versus-Host Disease in Children after Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Centre Experience","authors":"Utku Aygüneş, B. Karagün, H. I. Sasmaz, A. Antmen, Gökhan Tümgör","doi":"10.20515/otd.1420314","DOIUrl":"https://doi.org/10.20515/otd.1420314","url":null,"abstract":"Acute graft-versus-host disease is a common complication of allogeneic hematopoietic stem cell transplantation and is a major cause of morbidity and mortality. Systemic steroid therapy is the first-line treatment for acute graft-versus-host disease, although about half of patients will become refractory to treatment. We aimed to evaluate treatment options by reviewing available alternatives for patients with steroid-refractory acute graft-versus-host disease by comparing data from recently published studies. We retrospectively studied the safety and efficacy of treatment in 22 children with steroid‐dependent/refractory acute GVHD between the years 2010 and 2023. Seven (31.8%) out of 22 patients with acute graft-versus-host disease were still alive. The seven surviving patients have been followed for an average of 1141 (±403) days. 15 non-responders with grade III/IV acute graft-versus-host disease died from causes associated with acute graft-versus-host disease and/or other conditions. Among 15 patients who died, the number of patients who received all three treatments, MSC, ECP and infliximab, was 5 (33%). The most common cause of death was infection (8 cases in 15 patients, 53.3%). Other causes of death were gastrointestinal hemorrhages (n=5, 33.3%), and intracranial hemorrhages (n=2, 13.3%). When factors causing morbidity were evaluated, it was observed that three patients developed posterior reversible encephalopathy syndrome, two patients developed hepatic veno-occlusive disease, and one patient developed hypertension. The estimated probability of survival after 1 year was 31.8%, and the median survival was 655 days. We believe that it would be crucial to show the safety and efficacy of novel treatments in comprehensive, randomized clinical trials.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"6 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Yilmaz, Fuat Açıkalın, M. Pınarbaşlı, Ercan Kaya, İlknur Ak
This study aims to find out the incidence of malignant tumors originating from the salivary gland or other organs in patients with Warthin tumor (WT) and compare the clinicopathological, radiological, and demographic data of WT patients with or without malignant tumors. The study population consisted of 170 patients diagnosed with WT from cytology, surgery, and consultation materials between 2010 and 2021 in our hospital. Patient files were reviewed in terms of demographic data, smoking status, presence of malignant tumor, radiological findings, symptom duration, and operation procedure. A total of 40 malignant tumors were detected in 36 (21.2%) of 170 patients with WT. The most common localizations of malignant tumors were lung (35.0%), head and neck (35.0%), and genitourinary (12.5%) regions. The mean age of the patients with malignant tumor diagnosis (62.1±9.2) was higher than the patients without (56.5±9.8) (p=0.002). There was no significant difference between cases with and without malignant tumors in terms of gender, multifocality, bilaterality, amount of smoking, and pain complaints (p>0.05). The SUVmax of WTs ranged from 3 to 17.7 (median: 6.8, IQR: 5.5-11.0), and that of malignant tumors ranged from 2.7 to 16.2 (median: 8, IQR: 5.1-10.3) (p=0.756). This study demonstrates that WT can be seen with malignant tumors synchronously but also encountered before and after the malignant tumor diagnosis. This possibility should be considered, especially in the head and neck region, in patients diagnosed with malignant tumors or being investigated.
{"title":"Warthin tumor: Assessment of association with salivary gland and non-salivary gland malignant tumors via clinicopathological and radiological data","authors":"F. Yilmaz, Fuat Açıkalın, M. Pınarbaşlı, Ercan Kaya, İlknur Ak","doi":"10.20515/otd.1402983","DOIUrl":"https://doi.org/10.20515/otd.1402983","url":null,"abstract":"This study aims to find out the incidence of malignant tumors originating from the salivary gland or other organs in patients with Warthin tumor (WT) and compare the clinicopathological, radiological, and demographic data of WT patients with or without malignant tumors. The study population consisted of 170 patients diagnosed with WT from cytology, surgery, and consultation materials between 2010 and 2021 in our hospital. Patient files were reviewed in terms of demographic data, smoking status, presence of malignant tumor, radiological findings, symptom duration, and operation procedure. A total of 40 malignant tumors were detected in 36 (21.2%) of 170 patients with WT. The most common localizations of malignant tumors were lung (35.0%), head and neck (35.0%), and genitourinary (12.5%) regions. The mean age of the patients with malignant tumor diagnosis (62.1±9.2) was higher than the patients without (56.5±9.8) (p=0.002). There was no significant difference between cases with and without malignant tumors in terms of gender, multifocality, bilaterality, amount of smoking, and pain complaints (p>0.05). The SUVmax of WTs ranged from 3 to 17.7 (median: 6.8, IQR: 5.5-11.0), and that of malignant tumors ranged from 2.7 to 16.2 (median: 8, IQR: 5.1-10.3) (p=0.756). This study demonstrates that WT can be seen with malignant tumors synchronously but also encountered before and after the malignant tumor diagnosis. This possibility should be considered, especially in the head and neck region, in patients diagnosed with malignant tumors or being investigated.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"63 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emine Yağcı, Cansu Özbayer, Guntulu Ak, H. Kurt, Selma Metintaş, M. Metintaş
Lung cancer is a malignant lung tumor characterized by uncontrolled cell growth in lung tissue. Genetic and epigenetic abnormalities can be seen in lung cancer. These abnormalities can lead to activation of oncogene and inactivation of tumor suppressor genes. Inflammation is a powerful mediator of cancer development. Pulmonary inflammation may play a role in the initiation or progression of cancer. The main mediator of inflammation is inducible nitric oxide synthase (iNOS), which synthesizes nitric oxide from L-arginine. Monocyte chemoattractant protein-1 (MCP-1) is one of the important chemokines that regulate the migration and infiltration of monocytes/macrophages. It has been determined that MCP-1 plays an important role in lung allergic inflammation, lung leukocyte infiltration and bronchial hyperresponsiveness in the pathogenesis of asthma. Cyclooxygenases (COX) are responsible for prostaglandin production from arachidonic acid. They contribute to inflammation-induced carcinogenesis. COX2 is the enzyme responsible for inflammation induced by inflammatory stimuli, hormones and growth factors. In line with the information given, in this study, serum levels of COX2, iNOS and MCP-1 were determined using the ELISA method in 90 (36 adenocarcinoma, 36 squamous cell, 18 small cell carcinoma) lung cancer patients and 90 healthy control individuals. It was determined that COX2, iNOS and MCP-1 serum concentrations in lung cancer patients were significantly higher than in control individuals (p<0.001). However, no statistically significant difference was detected between lung cancer histological subtypes (p>0.05). It is thought that our findings may contribute to early diagnosis and development of new treatments for lung cancer.
{"title":"Elevated Serum Levels of Inducible Nitric Oxide Synthase, Monocyte Chemoattractant Protein-1, And Cyclooxygenase-2 In Patients with Lung Cancer","authors":"Emine Yağcı, Cansu Özbayer, Guntulu Ak, H. Kurt, Selma Metintaş, M. Metintaş","doi":"10.20515/otd.1386607","DOIUrl":"https://doi.org/10.20515/otd.1386607","url":null,"abstract":"Lung cancer is a malignant lung tumor characterized by uncontrolled cell growth in lung tissue. Genetic and epigenetic abnormalities can be seen in lung cancer. These abnormalities can lead to activation of oncogene and inactivation of tumor suppressor genes. Inflammation is a powerful mediator of cancer development. Pulmonary inflammation may play a role in the initiation or progression of cancer. The main mediator of inflammation is inducible nitric oxide synthase (iNOS), which synthesizes nitric oxide from L-arginine. Monocyte chemoattractant protein-1 (MCP-1) is one of the important chemokines that regulate the migration and infiltration of monocytes/macrophages. It has been determined that MCP-1 plays an important role in lung allergic inflammation, lung leukocyte infiltration and bronchial hyperresponsiveness in the pathogenesis of asthma. Cyclooxygenases (COX) are responsible for prostaglandin production from arachidonic acid. They contribute to inflammation-induced carcinogenesis. COX2 is the enzyme responsible for inflammation induced by inflammatory stimuli, hormones and growth factors. In line with the information given, in this study, serum levels of COX2, iNOS and MCP-1 were determined using the ELISA method in 90 (36 adenocarcinoma, 36 squamous cell, 18 small cell carcinoma) lung cancer patients and 90 healthy control individuals. It was determined that COX2, iNOS and MCP-1 serum concentrations in lung cancer patients were significantly higher than in control individuals (p<0.001). However, no statistically significant difference was detected between lung cancer histological subtypes (p>0.05). It is thought that our findings may contribute to early diagnosis and development of new treatments for lung cancer.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"251 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coexistence of pneumoretroperitoneum, pneumomediastinum, pneumothorax and subcutaneous emphysema after colonoscopy is a rarely seen condition. We present this rare clinical condition seen after colonoscopy to contribute to the literature. A 62-year-old male patient, who was operated for acute abdomen two years ago, underwent colonoscopy due to colon stenosis. He applied with the complaints of swelling in the neck and subcutaneous swelling in the chest and abdomen after the procedure. Pneumoretroperitoneum, pneumomediastinum and subcutaneous emphysema were detected in the patient In case of subcutaneous emphysema to be seen after colonoscopy, the possibility of pneumomediastinum and pneumothorax should also be considered.
{"title":"High Dose Cytosine Arabinoside- Induced Asymptomatic Bradycardia A Rare Case of Concurrent Pneumoretroperitoneum, Pneumomediastinum, Pneumothorax and Subcutaneous Emphysema Seen After Colonoscopy","authors":"Mehmet Agar, İlham Gülçek, M. Kalkan","doi":"10.20515/otd.1371016","DOIUrl":"https://doi.org/10.20515/otd.1371016","url":null,"abstract":"Coexistence of pneumoretroperitoneum, pneumomediastinum, pneumothorax and subcutaneous emphysema after colonoscopy is a rarely seen condition. We present this rare clinical condition seen after colonoscopy to contribute to the literature. A 62-year-old male patient, who was operated for acute abdomen two years ago, underwent colonoscopy due to colon stenosis. He applied with the complaints of swelling in the neck and subcutaneous swelling in the chest and abdomen after the procedure. Pneumoretroperitoneum, pneumomediastinum and subcutaneous emphysema were detected in the patient In case of subcutaneous emphysema to be seen after colonoscopy, the possibility of pneumomediastinum and pneumothorax should also be considered.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"114 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study is to evaluate the prognosis and mortality of acute pancreatitis (AP) in older subjects and compare octogenarians (≥80 years) with nonoctogenarians (age <80 years). The medical records of elderly patients who were followed up with the diagnosis of AP at our clinic between January 2018 and December 2021 were retrospectively analyzed. The etiology of AP, comorbidities, laboratory parameters, intensive care unit (ICU) admission, and mortality were noted. Among survivors, one-year mortality status was also recorded. Disease severity, in-hospital mortality and one-year mortality were compared. A total of 206 older patients (60 octogenarian, 146 nonoctogenariean) were recruited to the study. Of them, 115 (56%) were female and the mean age was 76.1±7.3 years. Severity of AP didn’t differ between octogenarians and nonctogenarians (p>0.05). ICU admission was seen in 13% of octogenarians and 11% of nonoctogenarians (p>0.05). In-hospital mortality occurred in 8.3% of octogenarians and 6.8% of nonoctogenarians (p>0.05). After discharge, one-year mortality occurred in 20% of octogenarians and 6.6% of nonoctogenarians (p<0.01). In multivariate analysis severe AP (OR:24.940;%95CI:1.013–95.609; p=0.01), ICU admission (OR:10.244;%95CI:1.399–74.990; p=0.01) and chronic kidney disease(CKD) (OR:9.840;%95CI:1.013–95.609; p=0.04) were independent risk factors for in-hospital mortality, and ≥80 years (OR:2.984;%95 CI:1.116–7.980; p =0.03) and neurological disorders (OR:4.424;%95CI:1.480–13.226; p <0.01) were independent factors related to one-year mortality. Our results showed that advenced age has not a significant effect on the course of AP in elderly. Comorbidities play important role in short- and long-term outcomes in elderly. Larger prospective trials are needed to draw more definitive conclusions.
本研究旨在评估老年急性胰腺炎（AP）的预后和死亡率，并将八旬老人（≥80 岁）与非八旬老人（0.05 岁）进行比较。13%的八旬老人和11%的非八旬老人住进了重症监护室（P>0.05）。8.3% 的八旬老人和 6.8% 的非八旬老人出现院内死亡（P>0.05）。出院后，20% 的八旬老人和 6.6% 的非八旬老人在一年内死亡（P<0.01）。在多变量分析中，严重 AP（OR:24.940;%95CI:1.013-95.609; p=0.01）、入住 ICU（OR:10.244;%95CI:1.399-74.990; p=0.01）和慢性肾脏病（CKD）（OR:9.840;%95CI:1.013-95.609; p=0.≥80岁（OR:2.984;%95CI:1.116-7.980; p =0.03）和神经系统疾病（OR:4.424;%95CI:1.480-13.226; p <0.01）是与一年死亡率相关的独立危险因素。我们的研究结果表明，年龄对老年人 AP 的病程影响不大。合并症对老年人的短期和长期预后都有重要影响。要得出更明确的结论，还需要进行更大规模的前瞻性试验。
{"title":"The Impact of Age Over 80 Years on Outcomes in Geriatric Patients with Acute Pancreatitis: A Single Center Experience","authors":"Hakan Şivgin, Abdurrahman Şahi̇n","doi":"10.20515/otd.1415422","DOIUrl":"https://doi.org/10.20515/otd.1415422","url":null,"abstract":"The aim of this study is to evaluate the prognosis and mortality of acute pancreatitis (AP) in older subjects and compare octogenarians (≥80 years) with nonoctogenarians (age <80 years). The medical records of elderly patients who were followed up with the diagnosis of AP at our clinic between January 2018 and December 2021 were retrospectively analyzed. The etiology of AP, comorbidities, laboratory parameters, intensive care unit (ICU) admission, and mortality were noted. Among survivors, one-year mortality status was also recorded. Disease severity, in-hospital mortality and one-year mortality were compared. A total of 206 older patients (60 octogenarian, 146 nonoctogenariean) were recruited to the study. Of them, 115 (56%) were female and the mean age was 76.1±7.3 years. Severity of AP didn’t differ between octogenarians and nonctogenarians (p>0.05). ICU admission was seen in 13% of octogenarians and 11% of nonoctogenarians (p>0.05). In-hospital mortality occurred in 8.3% of octogenarians and 6.8% of nonoctogenarians (p>0.05). After discharge, one-year mortality occurred in 20% of octogenarians and 6.6% of nonoctogenarians (p<0.01). In multivariate analysis severe AP (OR:24.940;%95CI:1.013–95.609; p=0.01), ICU admission (OR:10.244;%95CI:1.399–74.990; p=0.01) and chronic kidney disease(CKD) (OR:9.840;%95CI:1.013–95.609; p=0.04) were independent risk factors for in-hospital mortality, and ≥80 years (OR:2.984;%95 CI:1.116–7.980; p =0.03) and neurological disorders (OR:4.424;%95CI:1.480–13.226; p <0.01) were independent factors related to one-year mortality. Our results showed that advenced age has not a significant effect on the course of AP in elderly. Comorbidities play important role in short- and long-term outcomes in elderly. Larger prospective trials are needed to draw more definitive conclusions.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"1975 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140416726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ortanca tanı yaşı 68 olan akut myeloid lösemide (AML) intensif tedavi adayı olamayan ileri yaş grubunda sağkalım süresi belirgin olarak düşüktür. Günümüzde bu hasta grubu için standart tedavi haline gelen hipometilleyici ajan-venetoklaks (HMA-V) kombinasyonuyla sağkalım süresi ve yaşam kalitesi artmıştır. Biz de merkezimizde intensif tedaviye uygun olmayan AML hasta grubunda HMA-V kombinasyon tedavisi sonuçlarını incelemeyi amaçladık. Çalışmaya dahil edilen 37 hastanın ortanca yaşı 70.2 yıl ve %51.4’ ü kadın idi. Hastaların %73’ü de novo lösemi olup 4 hasta nüks, 1 hasta azasitidin sonrası refrakter hastalıktı. Remisyon sağlanan 2 hastaya intensif tedavi intoleransı/yan etkisi nedeniyle HMA-V kombinasyonu verildi. Azasitidin kullanım oranı %78.6 idi. Ortanca kurs sayısı 3 idi. 1. veya 2. kurs sonunda kemik iliği değerlendirmesinde remisyon oranı %51.4 olarak bulundu. Ortalama izlem süresi 11.9 ay olup hastaların %56.75’i hayatını kaybetti. Sağkalım analizlerinde ortalama ve ortanca yaşam süreleri 18 ve 13 ay olarak saptandı. Ortalama yaşam süreleri remisyon sağlananlarda, sağlanamayanlarda ve değerlendirilemeyenlerde sırasıyla 27.1, 4.1 ay ve ve 7.5 ay idi ve gruplar arasında anlamlı farklılık saptandı (p <0.001). Azasitidin ile ortalama ve ortanca yaşam süreleri 22.03 ve 23 ay iken, desitabin ile bu süreler sırasıyla 3.87 ve 3 ay idi ve belirgin istatiksel farklılık mevcuttu (p <0.001). Cox regresyon multivariate analizinde mortalite üzerinde etkili tek faktör 1./2. siklus sonu değerlendirmesinde remisyonda olmamak olarak bulundu (p 0.004). Sonuç olarak, merkezimizin sağkalım ve remisyon oranları gerçek yaşam çalışmalarıyla benzer olarak bulunmuştur.
{"title":"Evaluation Of Hypomethylating Agent Venetoclax Combination In Patients With Acute Myeloid Leukaemia Ineligible For Intensive Treatment","authors":"Tuğcan ALP KIRKIZLAR, Ahmet Muzaffer Demi̇r","doi":"10.20515/otd.1436206","DOIUrl":"https://doi.org/10.20515/otd.1436206","url":null,"abstract":"Ortanca tanı yaşı 68 olan akut myeloid lösemide (AML) intensif tedavi adayı olamayan ileri yaş grubunda sağkalım süresi belirgin olarak düşüktür. Günümüzde bu hasta grubu için standart tedavi haline gelen hipometilleyici ajan-venetoklaks (HMA-V) kombinasyonuyla sağkalım süresi ve yaşam kalitesi artmıştır. Biz de merkezimizde intensif tedaviye uygun olmayan AML hasta grubunda HMA-V kombinasyon tedavisi sonuçlarını incelemeyi amaçladık. Çalışmaya dahil edilen 37 hastanın ortanca yaşı 70.2 yıl ve %51.4’ ü kadın idi. Hastaların %73’ü de novo lösemi olup 4 hasta nüks, 1 hasta azasitidin sonrası refrakter hastalıktı. Remisyon sağlanan 2 hastaya intensif tedavi intoleransı/yan etkisi nedeniyle HMA-V kombinasyonu verildi. Azasitidin kullanım oranı %78.6 idi. Ortanca kurs sayısı 3 idi. 1. veya 2. kurs sonunda kemik iliği değerlendirmesinde remisyon oranı %51.4 olarak bulundu. Ortalama izlem süresi 11.9 ay olup hastaların %56.75’i hayatını kaybetti. Sağkalım analizlerinde ortalama ve ortanca yaşam süreleri 18 ve 13 ay olarak saptandı. Ortalama yaşam süreleri remisyon sağlananlarda, sağlanamayanlarda ve değerlendirilemeyenlerde sırasıyla 27.1, 4.1 ay ve ve 7.5 ay idi ve gruplar arasında anlamlı farklılık saptandı (p <0.001). Azasitidin ile ortalama ve ortanca yaşam süreleri 22.03 ve 23 ay iken, desitabin ile bu süreler sırasıyla 3.87 ve 3 ay idi ve belirgin istatiksel farklılık mevcuttu (p <0.001). Cox regresyon multivariate analizinde mortalite üzerinde etkili tek faktör 1./2. siklus sonu değerlendirmesinde remisyonda olmamak olarak bulundu (p 0.004). Sonuç olarak, merkezimizin sağkalım ve remisyon oranları gerçek yaşam çalışmalarıyla benzer olarak bulunmuştur.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"327 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140417230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It has been revealed that metastasectomy surgery performed on patients whose primary tumor is under control and who have only lung metastases can show better survival after complete surgical resection compared to cases with multiple organ metastases. In our study, we retrospectively shared our experience with metastasectomies and their impact on survival. In our clinic, 20 patients (12 men, 8 women; average age 49 years) who were operated on due to metastasis detected in the lung between 2010 and 2020 were retrospectively examined. Patients were determined according to age, gender, primary tumor pathology, disease-free time, radiologically and surgically. It was evaluated according to the number of metastatic lesions detected, the type of operation and the follow-up period. Respiratory function tests were performed on all patients. Patients with isolated pulmonary lesions whose primary tumors were under control underwent resection if their cardiopulmonary status was suitable for resection. Three of the twenty patients underwent video-assisted thoracoscopic surgery (VATS), and the other 17 patients underwent open thoracotomy, for a total of 28 metastasectomy operations. While the number of nodules detected before the operation was 39, a total of 51 nodules were excised during the operation. No major complications were observed. While 9 of our patients died due to widespread metastases within the 5-year postoperative period, 11 patients are being followed up disease-free without pulmonary metastases. It is known that metastasectomy positively affects survival in cases with isolated pulmonary metastases whose primary tumor is under control. The possibility of missing radiological findings when evaluating the number of nodules still makes the importance of open surgical treatment and digital palpation current in metastasectomy.
{"title":"Pulmonary Metastasectomy; Analyse and Clinical Overview of 20 Patients","authors":"Egemen Döner","doi":"10.20515/otd.1441332","DOIUrl":"https://doi.org/10.20515/otd.1441332","url":null,"abstract":"It has been revealed that metastasectomy surgery performed on patients whose primary tumor is under control and who have only lung metastases can show better survival after complete surgical resection compared to cases with multiple organ metastases. In our study, we retrospectively shared our experience with metastasectomies and their impact on survival. In our clinic, 20 patients (12 men, 8 women; average age 49 years) who were operated on due to metastasis detected in the lung between 2010 and 2020 were retrospectively examined. Patients were determined according to age, gender, primary tumor pathology, disease-free time, radiologically and surgically. It was evaluated according to the number of metastatic lesions detected, the type of operation and the follow-up period. Respiratory function tests were performed on all patients. Patients with isolated pulmonary lesions whose primary tumors were under control underwent resection if their cardiopulmonary status was suitable for resection. Three of the twenty patients underwent video-assisted thoracoscopic surgery (VATS), and the other 17 patients underwent open thoracotomy, for a total of 28 metastasectomy operations. While the number of nodules detected before the operation was 39, a total of 51 nodules were excised during the operation. No major complications were observed. While 9 of our patients died due to widespread metastases within the 5-year postoperative period, 11 patients are being followed up disease-free without pulmonary metastases. It is known that metastasectomy positively affects survival in cases with isolated pulmonary metastases whose primary tumor is under control. The possibility of missing radiological findings when evaluating the number of nodules still makes the importance of open surgical treatment and digital palpation current in metastasectomy.","PeriodicalId":409662,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"40 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140420403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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