Pub Date : 2003-09-01DOI: 10.4048/JKBCS.2003.6.3.148
Y. Jegal, Jung-han Yoon, C. Park
학적 측면에서 최근들어 각광을 받게된 분야로서 조직특 significance indicating bone marrow micrometastases. However, The cases possesing cytokeratin 8, 18, and 19 expression, altogether 75% or more showed a significantly high risk to bone marrow micrometastases. In that cases, addition of vimentin expression allowed a more higher possibility of bone marrow micrometastases. Conclusion: A high expression of cytokeratin 8 among cytokeratins was related with bone marrow metastases. However, vimentin expression by itself did not show any realtionship with bone marrow metastases. So, a further study is needed in order to reveal the role of vimentin expression in progression and metastases of breast cancer. (Journal of Korean Breast Cancer Society 2003;6:148154)
{"title":"Co-relationship between Expression of Keratins and Vimentin in Breast Cancer Tissures and Metastases of Breast Cancer","authors":"Y. Jegal, Jung-han Yoon, C. Park","doi":"10.4048/JKBCS.2003.6.3.148","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.3.148","url":null,"abstract":"학적 측면에서 최근들어 각광을 받게된 분야로서 조직특 significance indicating bone marrow micrometastases. However, The cases possesing cytokeratin 8, 18, and 19 expression, altogether 75% or more showed a significantly high risk to bone marrow micrometastases. In that cases, addition of vimentin expression allowed a more higher possibility of bone marrow micrometastases. Conclusion: A high expression of cytokeratin 8 among cytokeratins was related with bone marrow metastases. However, vimentin expression by itself did not show any realtionship with bone marrow metastases. So, a further study is needed in order to reveal the role of vimentin expression in progression and metastases of breast cancer. (Journal of Korean Breast Cancer Society 2003;6:148154)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130314346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-09-01DOI: 10.4048/JKBCS.2003.6.3.161
K. Kim, M. Heo, Seung Il Kim, Byeong-Woo Park
Purpose: Since the discovery of estrogen receptor-β (ERβ), five C-terminal variants of ER-β were identified. We designed this study to investigate the pattern and clinical implications of ER-β and its splicing variants expression in normal and malignant mammary tissues. Methods: Using reverse transcription polymerase chain reaction (RT-PCR), we examined the expression levels of ER-α and ER-β and its five splicing variants (β1, β2, β3, β4, β5) in 50 paired normal and cancer tissues. We measured the densities of RT-PCR products using Tina version 2.10 (Raytest, Germany). Firstly, the incidence and intensity of ER-α and ER-β and its five splicing variants were compared. Then the expression of ER-β mRNA splicing variants was also analyzed with regard to the ER-α protein expression measured by immuno-histochemical staining and the menopausal status of the patients. Chi-square test and paired samples t-test were used for statistical analysis. Differences were considered to be significant with a p-value of less than 0.05. Results: The expression of ER-β mRNA variants in normal breast and cancer tissues were as follows: ER-β2 (100%/100%), ER-β4 (76%/74%), ER-β5 (32%/58%), and ER-β1 (14%/16%). ER-β3 was not detected at all. In terms of intensity, we observed a significant decrease of ER-β2 (P<0.001) and an increase of ER-β5 (P=0.004) in the mRNA expression levels among breast cancers compared to the corresponding normal breast tissues. Compared to the corresponding normal tissues, a significant decrease of ER-β2 in cancer tissues was observed in patients with ER-α-positive (P<0.001), with age over 50 (P=0.01), and under 50 (P=0.04) as well, but not in patients with ER-α-negative (P=0.48). ER-β4 also significantly decreased in patients with ER-α-positive (P=0.004) and with age over 50 (P=0.07). ER-β5 showed a significant increment only in patient aged over 50 (P=0.04). Conclusion: ER-α mRNA expression significantly increases but ER-β mRNA expression decreases in the cancer tissues compared to the corresponding normal tissues. Among ER-β variant forms, ER-β2 is predominant in both normal and malignant mammary tissues and ER-β4, ER-β5, and ER-β1 in descending order but ER-β3 does not express in mammary tissues. The decrease of ER-β2 and ER-β4 expression is prominent in cancer tissue especially in ER-α-positive cancers, which suggests that ER-β2 and ER-β4 may possess a regulatory function in mammary carcinogenesis. Further investigations to verify the roles of ER-β variants are mandatory. (Journal of Korean Breast Cancer Society 2003;6:161-167)
{"title":"Expression of Estrogen Receptor-β and Its Variants in Normal Mammary and Tumor Tissues","authors":"K. Kim, M. Heo, Seung Il Kim, Byeong-Woo Park","doi":"10.4048/JKBCS.2003.6.3.161","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.3.161","url":null,"abstract":"Purpose: Since the discovery of estrogen receptor-β (ERβ), five C-terminal variants of ER-β were identified. We designed this study to investigate the pattern and clinical implications of ER-β and its splicing variants expression in normal and malignant mammary tissues. Methods: Using reverse transcription polymerase chain reaction (RT-PCR), we examined the expression levels of ER-α and ER-β and its five splicing variants (β1, β2, β3, β4, β5) in 50 paired normal and cancer tissues. We measured the densities of RT-PCR products using Tina version 2.10 (Raytest, Germany). Firstly, the incidence and intensity of ER-α and ER-β and its five splicing variants were compared. Then the expression of ER-β mRNA splicing variants was also analyzed with regard to the ER-α protein expression measured by immuno-histochemical staining and the menopausal status of the patients. Chi-square test and paired samples t-test were used for statistical analysis. Differences were considered to be significant with a p-value of less than 0.05. Results: The expression of ER-β mRNA variants in normal breast and cancer tissues were as follows: ER-β2 (100%/100%), ER-β4 (76%/74%), ER-β5 (32%/58%), and ER-β1 (14%/16%). ER-β3 was not detected at all. In terms of intensity, we observed a significant decrease of ER-β2 (P<0.001) and an increase of ER-β5 (P=0.004) in the mRNA expression levels among breast cancers compared to the corresponding normal breast tissues. Compared to the corresponding normal tissues, a significant decrease of ER-β2 in cancer tissues was observed in patients with ER-α-positive (P<0.001), with age over 50 (P=0.01), and under 50 (P=0.04) as well, but not in patients with ER-α-negative (P=0.48). ER-β4 also significantly decreased in patients with ER-α-positive (P=0.004) and with age over 50 (P=0.07). ER-β5 showed a significant increment only in patient aged over 50 (P=0.04). Conclusion: ER-α mRNA expression significantly increases but ER-β mRNA expression decreases in the cancer tissues compared to the corresponding normal tissues. Among ER-β variant forms, ER-β2 is predominant in both normal and malignant mammary tissues and ER-β4, ER-β5, and ER-β1 in descending order but ER-β3 does not express in mammary tissues. The decrease of ER-β2 and ER-β4 expression is prominent in cancer tissue especially in ER-α-positive cancers, which suggests that ER-β2 and ER-β4 may possess a regulatory function in mammary carcinogenesis. Further investigations to verify the roles of ER-β variants are mandatory. (Journal of Korean Breast Cancer Society 2003;6:161-167)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126260479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-09-01DOI: 10.4048/JKBCS.2003.6.3.189
Sang Il Lee, Cheol Joo Lee, J. Choi, Je Ryong Kim, E. Chang
우리나라 여성의 유방암은 서구화에 따라서 두 번째로 흔한 암으로 1999년 한국유방암등록 연례 보고서에 따르 면 여성의 전체 암 발생의 14.7%를 차지하였으며 식생활 의 변화와 함께 점차 증가하고 있다.(1) 유방암의 완치를 위해서는 유방 변형근치절제술 또는 유방 부분절제술 및 술 후 항암화학요법과 방사선 치료가 시행되는데 각각 치 료방법에 따라 국소재발률의 차이는 있지만 사망률에는 영향을 미치지 못한다.(2,3) 즉, 유방암 환자들에서 결국 술 후 보조적인 치료에도 불구하고 많은 환자들이 재발로 인하여 사망에 이르게 되는데 이는 국소재발로 인한 것보 다는 폐, 골, 간, 뇌 등 전신전이가 주를 이룬다. 술 후 보 조요법을 시행받지 않을 경우, 액와림프절에 전이가 있는 경우에는 약 75%, 전이가 없는 경우에는 약 30%가 전신 전이로 인하여 사망하게 된다. 이와 같은 원격전이의 재 발 원인은 진단 당시 이미 존재하는 미세전이에 기인하는 것으로 알려져 있다.(2,3) 따라서 수술 당시 존재하는 미세 전이에 대한 전신적인 치료가 생존율을 의미 있게 증가시 켰으나 여전히 원격전이로 인해 사망에 이르는 환자들이 상당 수 존재한다. 이는 대부분의 술 후 항암화학요법에 대한 세포의 내인성 혹은 획득성 저항성과 관련이 있다. (2-4) 이에 국소 진행성 또는 염증성 유방암 환자의 치료 성적을 향상시키는 방법의 하나로써 외과적 치료 전에 항 암화학요법을 시행하는 선행항암화학요법이 시행되고 있 다. 선행항암화학요법의 이론적 배경은 다음과 같다. 첫 째, 술 전 항암제를 투여함으로써 수술 후 미세전이가 급 격히 증식되는 것을 최소화할 수 있다. 둘째, 암종의 크기 cancer including patients with inflammatory breast cancer. (Journal of Korean Breast Cancer Society 2003;6:189195) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
韩国女性的乳腺癌西化第二常见的癌症按1999年韩国乳腺癌登记年度报告显示,女性占全部癌症发生的14.7%;与饮食生活的变化,正在逐步增加。(1)说,为了治愈乳腺癌乳房变形根治切除术或乳房部分切除术及术后抗癌化疗和放射线治疗得以实行,分别按照血栓病方法局部复发率的差异,但死亡率,不影响。(2、3),即在乳腺癌患者终于不顾术后辅助治疗,许多患者因复发造成死亡,这是由于局部复发引起的肺、骨间,大脑等全身战为主。术后不接受补养疗法，液和淋巴结转移约75%，无转移约30%因全身转移而死亡。这种远程战再发的原因是诊断当时已经存在的微转移引起的是众所周知的。(2、3)于是对手术当时存在的微小转移全身治疗,生存率有意义地增加了,但仍因远程战造成死亡的患者相当可能是存在的。这与大部分术后细胞对抗癌化学疗法的内源性或获得性抵抗有关。(2-4)作为提高局部进行性或炎症性乳房癌患者治疗成绩的方法之一，在进行外科治疗前实行抗癌化学疗法的先行抗癌化学疗法。先行抗癌化学疗法的理论背景如下。第一，通过在手术前注射抗癌剂，可以将手术后的微转移迅速增殖降至最低。第二，癌种的大小cancer including patients with inflammatory breast cancer。(journal of korean breast cancer society 2003; 6: 189195)ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
{"title":"Short Term Effect of Neoadjuvant Therapy with Docetaxel and Adriamycin in Advanced Breast Cancer","authors":"Sang Il Lee, Cheol Joo Lee, J. Choi, Je Ryong Kim, E. Chang","doi":"10.4048/JKBCS.2003.6.3.189","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.3.189","url":null,"abstract":"우리나라 여성의 유방암은 서구화에 따라서 두 번째로 흔한 암으로 1999년 한국유방암등록 연례 보고서에 따르 면 여성의 전체 암 발생의 14.7%를 차지하였으며 식생활 의 변화와 함께 점차 증가하고 있다.(1) 유방암의 완치를 위해서는 유방 변형근치절제술 또는 유방 부분절제술 및 술 후 항암화학요법과 방사선 치료가 시행되는데 각각 치 료방법에 따라 국소재발률의 차이는 있지만 사망률에는 영향을 미치지 못한다.(2,3) 즉, 유방암 환자들에서 결국 술 후 보조적인 치료에도 불구하고 많은 환자들이 재발로 인하여 사망에 이르게 되는데 이는 국소재발로 인한 것보 다는 폐, 골, 간, 뇌 등 전신전이가 주를 이룬다. 술 후 보 조요법을 시행받지 않을 경우, 액와림프절에 전이가 있는 경우에는 약 75%, 전이가 없는 경우에는 약 30%가 전신 전이로 인하여 사망하게 된다. 이와 같은 원격전이의 재 발 원인은 진단 당시 이미 존재하는 미세전이에 기인하는 것으로 알려져 있다.(2,3) 따라서 수술 당시 존재하는 미세 전이에 대한 전신적인 치료가 생존율을 의미 있게 증가시 켰으나 여전히 원격전이로 인해 사망에 이르는 환자들이 상당 수 존재한다. 이는 대부분의 술 후 항암화학요법에 대한 세포의 내인성 혹은 획득성 저항성과 관련이 있다. (2-4) 이에 국소 진행성 또는 염증성 유방암 환자의 치료 성적을 향상시키는 방법의 하나로써 외과적 치료 전에 항 암화학요법을 시행하는 선행항암화학요법이 시행되고 있 다. 선행항암화학요법의 이론적 배경은 다음과 같다. 첫 째, 술 전 항암제를 투여함으로써 수술 후 미세전이가 급 격히 증식되는 것을 최소화할 수 있다. 둘째, 암종의 크기 cancer including patients with inflammatory breast cancer. (Journal of Korean Breast Cancer Society 2003;6:189195) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115595028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-06-01DOI: 10.4048/JKBCS.2003.6.2.127
Byoung Kil Lee, Jin Hyo Kim, S. Jung
{"title":"Poland's Syndrome: Report of a Case","authors":"Byoung Kil Lee, Jin Hyo Kim, S. Jung","doi":"10.4048/JKBCS.2003.6.2.127","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.2.127","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116409786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-06-01DOI: 10.4048/JKBCS.2003.6.2.117
S. H. Kim, Tae Yun Kim, S. Kim, C. Lim, M. H. Lee
Purpose: Breast conserving surgery (BCS) is now widely accepted as the treatment of choice in early breast cancer. The extent of local excision has been controversial, owing to the risk of local recurrence and cosmesis. To improve breast cosmetic appearance following quadrantectomy for breast cancer, we propose a surgical technique of volume replacement with latissimus dorsi muscle (LD) flap. Methods: Twenty-eight patients underwent the immediate reconstruction of the defect with a LD flap after quadrantectomy for breast cancer between January 1999 and December 2000 at Soonchunhyang University Hospital. All patients had postoperative radiotherapy to the residual breast and, where appropriate, to the axilla. The mean tumor size was 2.38 cm (0.5 to 5.5 cm). And the mean age of patient was 39.2 years (18 to 69 years). Cosmetic outcome was evaluated by means of panel assessment and breast retraction assessment. Fivepanel scales were E0 to E4. BRA values were calculated by simple vector geometry employing the Pythagorean theorem. Results: 23 cases were scored as E0 (excellent, 82.1%), 4 case as E1 (good) and 1 case as E2 (moderate) cosmetic results. BRA values for the patients ranged 0.5 to 3.5 cm with a mean of 1.2 cm and for a group of 30 control women values ranged from 0.4 to 1.8 cm with mean value of 0.9 cm. When panel scores and BRA values were compared, 23 cases of excellent (E0) scoring had under the 3.5 cm of BRA value. No one of cases had over 3.5 cm of BRA value. 23 cases of excellent (E0) scoring old had satisfactory cosmetic results by panel scoring and BRA value. Conclusion: We concluded that the surgical technique of volume replacement with LD flap is useful for preventing breast deformity after quadrantectomy for breast cancer. (Journal of Korean Breast Cancer Society 2003;6:117-123)
{"title":"Immediate Volume Replacement with Latissimus Dorsi Muscle Flap after Quadrantectomy for Patients with Breast Cancer","authors":"S. H. Kim, Tae Yun Kim, S. Kim, C. Lim, M. H. Lee","doi":"10.4048/JKBCS.2003.6.2.117","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.2.117","url":null,"abstract":"Purpose: Breast conserving surgery (BCS) is now widely accepted as the treatment of choice in early breast cancer. The extent of local excision has been controversial, owing to the risk of local recurrence and cosmesis. To improve breast cosmetic appearance following quadrantectomy for breast cancer, we propose a surgical technique of volume replacement with latissimus dorsi muscle (LD) flap. Methods: Twenty-eight patients underwent the immediate reconstruction of the defect with a LD flap after quadrantectomy for breast cancer between January 1999 and December 2000 at Soonchunhyang University Hospital. All patients had postoperative radiotherapy to the residual breast and, where appropriate, to the axilla. The mean tumor size was 2.38 cm (0.5 to 5.5 cm). And the mean age of patient was 39.2 years (18 to 69 years). Cosmetic outcome was evaluated by means of panel assessment and breast retraction assessment. Fivepanel scales were E0 to E4. BRA values were calculated by simple vector geometry employing the Pythagorean theorem. Results: 23 cases were scored as E0 (excellent, 82.1%), 4 case as E1 (good) and 1 case as E2 (moderate) cosmetic results. BRA values for the patients ranged 0.5 to 3.5 cm with a mean of 1.2 cm and for a group of 30 control women values ranged from 0.4 to 1.8 cm with mean value of 0.9 cm. When panel scores and BRA values were compared, 23 cases of excellent (E0) scoring had under the 3.5 cm of BRA value. No one of cases had over 3.5 cm of BRA value. 23 cases of excellent (E0) scoring old had satisfactory cosmetic results by panel scoring and BRA value. Conclusion: We concluded that the surgical technique of volume replacement with LD flap is useful for preventing breast deformity after quadrantectomy for breast cancer. (Journal of Korean Breast Cancer Society 2003;6:117-123)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129633758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-06-01DOI: 10.4048/JKBCS.2003.6.2.95
S. Kang, E. Lee, H. Kang, J. Ro, S. Lee, K. Kang
{"title":"Neoadjuvant Chemotherapy Decreases the Identification Rate of Sentinel Lymph Node Biopsy","authors":"S. Kang, E. Lee, H. Kang, J. Ro, S. Lee, K. Kang","doi":"10.4048/JKBCS.2003.6.2.95","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.2.95","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128506013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-06-01DOI: 10.4048/JKBCS.2003.6.2.87
Cheong Sook Lee, J. Bong, Jin Hyun Park, Yoon Sik Lee, S. Paik, M. Shin, H. Oh, M. Jeong, Byung Chul Lee
mammography, and sonography for axillary node involvement were 37.5%, 57.7%, and 73.9%, respectively, and with specificity of 98.1%, 86.5%, and 92.9%, respectively, and with positive predictive value of 93.8%, 75.0%, and 85.0%, respectively. Conclusion: Physical examination is the best non-invasive predictor of the real size of palpable primary breast cancer, whereas high resolution duplex ultrasonography is most sensitive assessment method of axillary lymph node status. The specificity of axillary nodal status can be increased by fine-needle biopsy under sonographic guidance and it can be serve as useful adjuncts to sentinel node biopsy. (Journal of Korean Breast Cancer Society 2003;6:87-94)
{"title":"The Accuracy of the Physical Examination, Mammography, and Ultrasonography in the Assessment of Tumor Size and Axillary Lymph Node Metastasis in Breast Cancer Patient","authors":"Cheong Sook Lee, J. Bong, Jin Hyun Park, Yoon Sik Lee, S. Paik, M. Shin, H. Oh, M. Jeong, Byung Chul Lee","doi":"10.4048/JKBCS.2003.6.2.87","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.2.87","url":null,"abstract":"mammography, and sonography for axillary node involvement were 37.5%, 57.7%, and 73.9%, respectively, and with specificity of 98.1%, 86.5%, and 92.9%, respectively, and with positive predictive value of 93.8%, 75.0%, and 85.0%, respectively. Conclusion: Physical examination is the best non-invasive predictor of the real size of palpable primary breast cancer, whereas high resolution duplex ultrasonography is most sensitive assessment method of axillary lymph node status. The specificity of axillary nodal status can be increased by fine-needle biopsy under sonographic guidance and it can be serve as useful adjuncts to sentinel node biopsy. (Journal of Korean Breast Cancer Society 2003;6:87-94)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126987372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-06-01DOI: 10.4048/JKBCS.2003.6.2.68
Soo‐Jung Ahn, Ji‐Yeon Bae, R. Lee, W. Han, S. Kim, H. Chae, D. Noh
{"title":"Protective Role of Prx(Peroxiredoxin) I and II against H2O2-Induced Apoptosis of MCF7 Cell Lines","authors":"Soo‐Jung Ahn, Ji‐Yeon Bae, R. Lee, W. Han, S. Kim, H. Chae, D. Noh","doi":"10.4048/JKBCS.2003.6.2.68","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.2.68","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127025481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-06-01DOI: 10.4048/JKBCS.2003.6.2.124
Kwang Jo Kim, J. Ryu, N. Myong
{"title":"Report of Benign and Malignant Adenomyoepithelioma of the Breast","authors":"Kwang Jo Kim, J. Ryu, N. Myong","doi":"10.4048/JKBCS.2003.6.2.124","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.2.124","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125078260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-06-01DOI: 10.4048/JKBCS.2003.6.2.81
M. Choi, Jung-han Yoon, Y. Jaegal
Purpose: Cells of mammary gland as well as breast cancer uptake iodide through sodium/iodide symporter (NIS). The pathophysiologic importance of NIS is not evaluated well. The purpose of this study is to find relationships between the expression of NIS and other findings of breast cancer including ER, PR, C-erbB2, topoisomerase IIa, p53, and histologic grade of breast cancer. Methods: Fresh frozen specimens from 21 female breast cancer patients (mean age 50±13 years) with breast cancer were examined by RT-PCR for NIS mRNA. Immunohistochemical staining for ER, PR, C-erb B2, topoisomerase IIa and p53. Staging and degree of differentiation of cancer cells were also performed to evaluate the biological behavior of breast cancer. Results: NIS mRNA was expressed in 90% of the evaluated breast cancer tissues. The mean semiquantitative value of NIS mRNA in PR positive group was 2.02±0.35, which was higher than that of PR negative group (1.11±0.18; P=0.001). ER positive group showed higher value of NIS mRNA (2.02±0.35) than ER negative group (1.19±0.63; P=0.002). In addition, NIS mRNA values was significantly different according to differentiation of cancer cells (well differentiated type, 2.20±0.37 vs. less differentiated type, 1.39±0.63, P=0.01). However, there was no significant association between NIS mRNA levels and the other biologic characteriscs such as C-erb B2, topoisomerase IIa, and p53. Conclusion: The results showed that the expression of NIS in breast cancer may be associated with the presence of PR and ER as well as the degree of differentiation of breast cancer cells. (Journal of Korean Breast Cancer Society 2003;6:81-86)
{"title":"Factors Associated with Expression of Sodium/iodide Symporter (NIS) mRNA in Breast Cancer","authors":"M. Choi, Jung-han Yoon, Y. Jaegal","doi":"10.4048/JKBCS.2003.6.2.81","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.2.81","url":null,"abstract":"Purpose: Cells of mammary gland as well as breast cancer uptake iodide through sodium/iodide symporter (NIS). The pathophysiologic importance of NIS is not evaluated well. The purpose of this study is to find relationships between the expression of NIS and other findings of breast cancer including ER, PR, C-erbB2, topoisomerase IIa, p53, and histologic grade of breast cancer. Methods: Fresh frozen specimens from 21 female breast cancer patients (mean age 50±13 years) with breast cancer were examined by RT-PCR for NIS mRNA. Immunohistochemical staining for ER, PR, C-erb B2, topoisomerase IIa and p53. Staging and degree of differentiation of cancer cells were also performed to evaluate the biological behavior of breast cancer. Results: NIS mRNA was expressed in 90% of the evaluated breast cancer tissues. The mean semiquantitative value of NIS mRNA in PR positive group was 2.02±0.35, which was higher than that of PR negative group (1.11±0.18; P=0.001). ER positive group showed higher value of NIS mRNA (2.02±0.35) than ER negative group (1.19±0.63; P=0.002). In addition, NIS mRNA values was significantly different according to differentiation of cancer cells (well differentiated type, 2.20±0.37 vs. less differentiated type, 1.39±0.63, P=0.01). However, there was no significant association between NIS mRNA levels and the other biologic characteriscs such as C-erb B2, topoisomerase IIa, and p53. Conclusion: The results showed that the expression of NIS in breast cancer may be associated with the presence of PR and ER as well as the degree of differentiation of breast cancer cells. (Journal of Korean Breast Cancer Society 2003;6:81-86)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"679 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123159126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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