Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.275
E. Ahn, Hyun-Ah Kim, B. Moon, H. Choi, S. Sung
33 false positive false negative ex were 83.3%, 91.8%, 60.6%, 97.3%, 8.2%, 16.7% and 90.7% Conclusion: Ex vivo ultrasound evaluation for detecting sentinel lymph node during the be helpful to decide the extent lymph Purpose: The presence of lymph node metastasis is a key factor for deciding upon radical axillary dissection during a breast cancer operation. We performed prospective research to assess the accuracy and effectiveness of ex vivo ultrasound for detecting sentinel node metastasis during the operation. Methods: 183 fresh sentinel lymph nodes from 30 breast cancer patients had sonographic examination performed on them by a specialized radiologist immediately after surgical resection. The sonographic criteria for malignant lymph nodes were uneven cortical thickness, a node more than 3 mm in diameter, the absence of the hilum and a round hypoechoic node. After sonographic evaluation, the speci-men were delivered to the department of pathology for frozen biopsy and permanent staining. Results: Among 133 lymph nodes that were examined on frozen sectioning, 12 (9.0%) were revealed as metastatic nodes and 121 (90.9%) were revealed as benign. On US examination, 150 (81.9%) among the detected 183 nodes were read as benign and 33 (18.1%) were read as metastatic. Among 150 benign nodes, four (2.6%) were proven as metastasis on permanent pathology, and 20 (60.6%)
{"title":"Effectiveness of Ex vivo Ultrasound for Detecting Sentinel Node Metastasis in Breast Cancer","authors":"E. Ahn, Hyun-Ah Kim, B. Moon, H. Choi, S. Sung","doi":"10.4048/JKBCS.2004.7.4.275","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.275","url":null,"abstract":"33 false positive false negative ex were 83.3%, 91.8%, 60.6%, 97.3%, 8.2%, 16.7% and 90.7% Conclusion: Ex vivo ultrasound evaluation for detecting sentinel lymph node during the be helpful to decide the extent lymph Purpose: The presence of lymph node metastasis is a key factor for deciding upon radical axillary dissection during a breast cancer operation. We performed prospective research to assess the accuracy and effectiveness of ex vivo ultrasound for detecting sentinel node metastasis during the operation. Methods: 183 fresh sentinel lymph nodes from 30 breast cancer patients had sonographic examination performed on them by a specialized radiologist immediately after surgical resection. The sonographic criteria for malignant lymph nodes were uneven cortical thickness, a node more than 3 mm in diameter, the absence of the hilum and a round hypoechoic node. After sonographic evaluation, the speci-men were delivered to the department of pathology for frozen biopsy and permanent staining. Results: Among 133 lymph nodes that were examined on frozen sectioning, 12 (9.0%) were revealed as metastatic nodes and 121 (90.9%) were revealed as benign. On US examination, 150 (81.9%) among the detected 183 nodes were read as benign and 33 (18.1%) were read as metastatic. Among 150 benign nodes, four (2.6%) were proven as metastasis on permanent pathology, and 20 (60.6%)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134628183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.282
W. Pae, Y. Park, Eun-Kyu Lee
{"title":"Endoscopic Subcutaneous Mastectomy and Immediate Reconstruction of Breast Cancer","authors":"W. Pae, Y. Park, Eun-Kyu Lee","doi":"10.4048/JKBCS.2004.7.4.282","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.282","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"517 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133496835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-01DOI: 10.4048/JKBCS.2004.7.4.217
Hyun A Cho, M. Rhyu, S. Choi, S. Yun, S. Lee, S. Jung, Sang‐Wook Choi, E. Seo
Purpose: The extent of the loss of heterozygosity (LOH) has been used as the genetic parameter for the classification and staging of some solid tumors. Breast cancers such as ductal carcinoma in situ (DCIS), and invasive and metastatic lesions, are frequently observed to contain heterogeneous tumor foci. To delineate the relation between the LOH and the progression of breast cancers, three successive histological sites in a tumor lesion were analyzed for LOH events. Methods: We tested 111 tumor site including DCIS, and invasive, and metastatic lymph nodes from 50 breast cancers for LOH using 5 microsatellite makers on 8 chromosomal arms (3p, 4p, 5q, 8p, 9p, 13q, 17p, & 18q). Results: Twenty-four of 34 breast cancers showing intratumoral histological heterogeneity had common chromosomal losses in the heterogeneous tumor sites, as well as having divergent losses that were restricted to a part of tumor lesion (mean divergent loss, 2.32). The number and frequency of heterogeneous chromosomal losses were not significantly related with age, tumor size, and stage. Overall, at least one chromosomal loss was detected in 48 cases, and incidences of LOH in each chromosome were 27.1∼63.3%. A large fraction (58%) of breast cancer patients had 2 to 4 chromosomal losses, and chromosome 8p was most frequently lost (63%). When comparing the number of chromosomal losses in nine cases with all of three progressive lesions, the lost extent was greater in the DCIS (mean losses, 4.44) than in the invasive sites (mean losses, 3.1) and the metastatic lymph nodes (mean losses, 2.9). Moderate-level chromosomal losses involving 3-5 chromosomes were significantly related with lymph node metastasis (p=0.006) and the advanced tumor stage (p<0.005), whereas low-level losses involving 1∼2 chromosomes and high-level losses involving 6∼7 chromosomes were more common in DCIS and early-stage diseases. Conclusion: The DCIS, invasive, and metastatic sites of a breast cancer patient contained common and divergent chromosomal losses. This indicates the concurrent expansion of different subclones was derived from a common ancestor clone, in which an optimal range of chromosomal losses, rather than high-level chromosomal losses, was more frequently associated with lymph node metastasis and the advanced tumor stages. (Journal of Korean Breast Cancer Society 2004;7:217-227)
{"title":"Genetic Classification of Breast Cancer based on Unilateral Chromosomal Loss","authors":"Hyun A Cho, M. Rhyu, S. Choi, S. Yun, S. Lee, S. Jung, Sang‐Wook Choi, E. Seo","doi":"10.4048/JKBCS.2004.7.4.217","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.4.217","url":null,"abstract":"Purpose: The extent of the loss of heterozygosity (LOH) has been used as the genetic parameter for the classification and staging of some solid tumors. Breast cancers such as ductal carcinoma in situ (DCIS), and invasive and metastatic lesions, are frequently observed to contain heterogeneous tumor foci. To delineate the relation between the LOH and the progression of breast cancers, three successive histological sites in a tumor lesion were analyzed for LOH events. Methods: We tested 111 tumor site including DCIS, and invasive, and metastatic lymph nodes from 50 breast cancers for LOH using 5 microsatellite makers on 8 chromosomal arms (3p, 4p, 5q, 8p, 9p, 13q, 17p, & 18q). Results: Twenty-four of 34 breast cancers showing intratumoral histological heterogeneity had common chromosomal losses in the heterogeneous tumor sites, as well as having divergent losses that were restricted to a part of tumor lesion (mean divergent loss, 2.32). The number and frequency of heterogeneous chromosomal losses were not significantly related with age, tumor size, and stage. Overall, at least one chromosomal loss was detected in 48 cases, and incidences of LOH in each chromosome were 27.1∼63.3%. A large fraction (58%) of breast cancer patients had 2 to 4 chromosomal losses, and chromosome 8p was most frequently lost (63%). When comparing the number of chromosomal losses in nine cases with all of three progressive lesions, the lost extent was greater in the DCIS (mean losses, 4.44) than in the invasive sites (mean losses, 3.1) and the metastatic lymph nodes (mean losses, 2.9). Moderate-level chromosomal losses involving 3-5 chromosomes were significantly related with lymph node metastasis (p=0.006) and the advanced tumor stage (p<0.005), whereas low-level losses involving 1∼2 chromosomes and high-level losses involving 6∼7 chromosomes were more common in DCIS and early-stage diseases. Conclusion: The DCIS, invasive, and metastatic sites of a breast cancer patient contained common and divergent chromosomal losses. This indicates the concurrent expansion of different subclones was derived from a common ancestor clone, in which an optimal range of chromosomal losses, rather than high-level chromosomal losses, was more frequently associated with lymph node metastasis and the advanced tumor stages. (Journal of Korean Breast Cancer Society 2004;7:217-227)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125295423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-09-01DOI: 10.4048/JKBCS.2004.7.3.193
Pyong Chan Lee, B. Son, J. Kwon, W. Lee, K. Lee
우리나라에서도 2001년도 들어 구미여성에서와 같이 유 방암이 여성 암의 1위를 차지하면서 1995년도에 비해 불 과 7, 8년 사이에 2배 가까운 비율로 급속히 증가하고 있 는 추세이다.(1) 영국의 외과의사인 John of Aderne가 1307 년 처음으로 남성 유방암에 대해 언급한 이후 20세기에 들어서도 대규모의 연구가 진행되지 않았던 남성 유방암 은 그 분포가 여성 유방암의 경우와 비슷하여 여성 및 남 성 유방암 모두 실제적으로 없는 지역은 없으나, 여성 유 방암의 빈도가 높은 지역이 남성 유방암의 빈도도 높게 보고되고 있다. 인종별, 지역별 예외적인 보고가 있기는 하지만, 남성 유방암의 경우는 여성에서 생기는 경우보다 희귀하고 발견 역시 늦어지는 결과로 예후면에 있어서 좋 지 않은 결과가 우세했다. 그러나 최근 Crichlow 등(2)에 의하면 남성 유방암은 여성과 동일병기를 기준으로 볼 때 같은 생존 및 예후를 나타낸다고 한다. 저자는 1989년부 터 2003년까지 4,809예의 유방암 환자 중 기록이 온전하 며 추적이 가능했던 13예의 유방암을 문헌고찰과 함께 보 고하고자 한다. 제한된 소규모의 임상경험과 정립된 문헌의 부재는 남 성 유방암의 원인과 치료법, 예후 및 생존율의 파악에도 많은 어려움을 주고 있다. 이에 체계적인 작업 하에 확신 있는 결론이 밝혀질 수 있도록 꾸준한 관심과 추적조사가
在我国，2001年也像欧美女性一样，乳房癌占据了女性癌的第一位，与1995年相比，“火与7”8年之间近2倍的比率正在迅速增加的趋势。(1)英国外科医生的john of aderne 1307年首次谈及男性乳腺癌后,进入20世纪都未进行大规模研究的男性乳腺癌是其分布与女性乳腺癌的情况相似,女性及性乳腺癌别人都没有切实的地区,但女性乳癌频率较高的地区男性乳房癌的频率也被报告为较高。虽然有不同人种、不同地区的例外报告，但是男性乳房癌的情况比女性罕见，发现也较晚，因此在预后方面不好的结果占优。但是最近根据Crichlow等(2)的研究，男性乳房癌与女性以同一病期为标准，显示出同样的生存及预后。作者将对1989年至2003年的4809例乳房癌患者中记录完整、可以追踪的13例乳房癌进行文献考察。有限的小规模临床经验和文献的缺失给掌握男性乳腺癌的原因和治疗方法、预后及生存率带来了很多困难。为了能在系统的工作下得出确切的结论，我们需要持续的关心和追踪调查
{"title":"Clinical Features of the Male Breast Cancer-13 Cases","authors":"Pyong Chan Lee, B. Son, J. Kwon, W. Lee, K. Lee","doi":"10.4048/JKBCS.2004.7.3.193","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.3.193","url":null,"abstract":"우리나라에서도 2001년도 들어 구미여성에서와 같이 유 방암이 여성 암의 1위를 차지하면서 1995년도에 비해 불 과 7, 8년 사이에 2배 가까운 비율로 급속히 증가하고 있 는 추세이다.(1) 영국의 외과의사인 John of Aderne가 1307 년 처음으로 남성 유방암에 대해 언급한 이후 20세기에 들어서도 대규모의 연구가 진행되지 않았던 남성 유방암 은 그 분포가 여성 유방암의 경우와 비슷하여 여성 및 남 성 유방암 모두 실제적으로 없는 지역은 없으나, 여성 유 방암의 빈도가 높은 지역이 남성 유방암의 빈도도 높게 보고되고 있다. 인종별, 지역별 예외적인 보고가 있기는 하지만, 남성 유방암의 경우는 여성에서 생기는 경우보다 희귀하고 발견 역시 늦어지는 결과로 예후면에 있어서 좋 지 않은 결과가 우세했다. 그러나 최근 Crichlow 등(2)에 의하면 남성 유방암은 여성과 동일병기를 기준으로 볼 때 같은 생존 및 예후를 나타낸다고 한다. 저자는 1989년부 터 2003년까지 4,809예의 유방암 환자 중 기록이 온전하 며 추적이 가능했던 13예의 유방암을 문헌고찰과 함께 보 고하고자 한다. 제한된 소규모의 임상경험과 정립된 문헌의 부재는 남 성 유방암의 원인과 치료법, 예후 및 생존율의 파악에도 많은 어려움을 주고 있다. 이에 체계적인 작업 하에 확신 있는 결론이 밝혀질 수 있도록 꾸준한 관심과 추적조사가","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133879637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-09-01DOI: 10.4048/JKBCS.2004.7.3.185
Ki-beom Ku, M. Bang, J. Choi, Yoon Sik Lee, Jin Hyun Park, Hyun Ok Kim, M. Jeong, H. Oh, J. Bong
유방의 엽상 종양은 전체 유방종양의 0.3∼1.0%를 차지 하는 드문 종양으로, 말단 관-엽 단위(terminal duct-lobular unit)의 상피와 기질성분에서 기원하며, 섬유상피종양의 약 2.5%를 차지한다.(1,2) 유방의 엽상종양은 저배율 소견 상 섬유선종과 유사하게 보이나 조직학적으로 기질세포 밀도의 증가와 나뭇잎 모양의 잘 발달된 증식형태, 그리 고 임상적으로 악성화 경로를 밟을 수 있다는 점에서 구 별된다.(3) 조직학적 범주에 기초하여 엽상종양은 양성과 악성으 로 분류되고, 더 세분하여 악성은 저등급(low-grade) 혹은 경계성(borderline)과 고등급(high-grade) 악성 종양으로 분 류되는데, 이러한 분류기준은 아직까지 명확하게 확립되 어 있지 않으며 따라서 여러 연구에 따라 다양하다.(4,5) 엽상종양은 일반적으로 그 특징적인 조직학적 특성에 따 라 진단된다. 그러나 양성종양과 악성종양의 구분이 쉽지 않고 주관적이어서 임상결과와 일치하지 않는 경우도 있 다. 양성종양에서도 국소재발과 전이가 가능하며 때로는 임상적으로 악성의 경과를 보이는 경우도 있는 반면, 많 은 조직학적 악성종양이 재발이나 전이를 보이지 않는다 고 보고되고 있으므로 종양의 다양한 조직학적 형태와 임 상적인 경과 사이의 연관성을 알기 위한 많은 시도들이 있었으나 종양의 임상적 결과를 예측하는 데는 성공적이 지 못하였다.(4-7) 최근 증식 표지자인 Ki-67과 종양억제 유전자인 p53이 유방암과 특히 엽상종양의 예후를 예측하는 데 적용될 수 있는지에 대한 연구들이 보고되고 있다.(2,8) 이에 저자들은 유방 엽상종양을 조직학적 소견에 따라 양성, 저등급 악성, 고등급 악성으로 분류하고 그 임상적 Clinical, Pathologic and Immunohistochemical Features of Phyllodes Tumor of the Breast
乳房叶状肿瘤占整个乳房肿瘤的0.3 - 1.0%，是一种罕见的肿瘤，起源于末端管-叶单位(terminal duct-lobular unit)的上皮和基质。纤维上皮肿瘤约占2.5%。(1、2)到乳房的叶来往量低倍率坏纤维看起来像禅宗和组织上气质科细胞密度的增加和树叶形状的增殖形式非常发达,那么,临床可以踩到恶性化途径。从这一点看,各具。(3)组织范畴的基础上叶来往量被分为良性和恶性的,,更细分,恶性的低等级(low - grade)或警戒性(borderline)和高等级(high - grade)恶性肿瘤分类,可这种分类标准还不明确确立了,因此,根据各种研究多种多样。(4、5)叶来往量一般按照其特点的组织心理学特性诊断。但由于很难区分良性肿瘤和恶性肿瘤，而且是主观的，所以也有与临床结果不一致的情况。良性肿瘤也有可能局部复发和转移，有时在临床上有恶性循环。很多组织恶性肿瘤复发或转移学籍不见了,报告,肿瘤的多种组织形式和学籍主任理想经过之间的关联性,知道有很多尝试,但为了预测肿瘤的临床结果是没有成功。(4 - 7)最近和ki - 67增殖标志作为肿瘤抑制基因p53乳腺癌和特别是叶相处会大量用于预测预后(2,8)根据组织学分析，作者将乳房叶状瘤分为阳性、低等恶性和高等恶性，并将其临床的Clinical、Pathologic and Immunohistochemical Features of Phyllodes Tumor of the Breast。
{"title":"Clinical, Pathologic and Immunohistochemical Features of Phyllodes Tumor of the Breast","authors":"Ki-beom Ku, M. Bang, J. Choi, Yoon Sik Lee, Jin Hyun Park, Hyun Ok Kim, M. Jeong, H. Oh, J. Bong","doi":"10.4048/JKBCS.2004.7.3.185","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.3.185","url":null,"abstract":"유방의 엽상 종양은 전체 유방종양의 0.3∼1.0%를 차지 하는 드문 종양으로, 말단 관-엽 단위(terminal duct-lobular unit)의 상피와 기질성분에서 기원하며, 섬유상피종양의 약 2.5%를 차지한다.(1,2) 유방의 엽상종양은 저배율 소견 상 섬유선종과 유사하게 보이나 조직학적으로 기질세포 밀도의 증가와 나뭇잎 모양의 잘 발달된 증식형태, 그리 고 임상적으로 악성화 경로를 밟을 수 있다는 점에서 구 별된다.(3) 조직학적 범주에 기초하여 엽상종양은 양성과 악성으 로 분류되고, 더 세분하여 악성은 저등급(low-grade) 혹은 경계성(borderline)과 고등급(high-grade) 악성 종양으로 분 류되는데, 이러한 분류기준은 아직까지 명확하게 확립되 어 있지 않으며 따라서 여러 연구에 따라 다양하다.(4,5) 엽상종양은 일반적으로 그 특징적인 조직학적 특성에 따 라 진단된다. 그러나 양성종양과 악성종양의 구분이 쉽지 않고 주관적이어서 임상결과와 일치하지 않는 경우도 있 다. 양성종양에서도 국소재발과 전이가 가능하며 때로는 임상적으로 악성의 경과를 보이는 경우도 있는 반면, 많 은 조직학적 악성종양이 재발이나 전이를 보이지 않는다 고 보고되고 있으므로 종양의 다양한 조직학적 형태와 임 상적인 경과 사이의 연관성을 알기 위한 많은 시도들이 있었으나 종양의 임상적 결과를 예측하는 데는 성공적이 지 못하였다.(4-7) 최근 증식 표지자인 Ki-67과 종양억제 유전자인 p53이 유방암과 특히 엽상종양의 예후를 예측하는 데 적용될 수 있는지에 대한 연구들이 보고되고 있다.(2,8) 이에 저자들은 유방 엽상종양을 조직학적 소견에 따라 양성, 저등급 악성, 고등급 악성으로 분류하고 그 임상적 Clinical, Pathologic and Immunohistochemical Features of Phyllodes Tumor of the Breast","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115076171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-09-01DOI: 10.4048/JKBCS.2004.7.3.180
G. Son, Tae Hyoung Kim, J. Um, J. Lee, J. Bae, B. Koo
{"title":"Axillary Lymph Node Metastasis in Patients of Ductal Carcinoma in Situ or Ductal Carcinoma in Situ with Microinvasion","authors":"G. Son, Tae Hyoung Kim, J. Um, J. Lee, J. Bae, B. Koo","doi":"10.4048/JKBCS.2004.7.3.180","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.3.180","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126706571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-09-01DOI: 10.4048/JKBCS.2004.7.3.166
J. Choi, Y. Ha, Yoon Sik Lee, Jin Hyun Park, M. Jeong, Hyun Ok Kim, H. Oh, J. Bong
{"title":"Prognostic Significance of Peritumoral Vascular Invasion in Patients with Invasive Breast Cancer","authors":"J. Choi, Y. Ha, Yoon Sik Lee, Jin Hyun Park, M. Jeong, Hyun Ok Kim, H. Oh, J. Bong","doi":"10.4048/JKBCS.2004.7.3.166","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.3.166","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115069133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-09-01DOI: 10.4048/JKBCS.2004.7.3.141
L. Kim, J. Price
Once breast cancer has been diagnosed, the most important question is whether the cancer is confined to the breast or has spread to distant sites. The majority of the death of women with breast cancer result from the growth of metastases that do not respond to therapy.(1) The development of more effective therapies should be based on a better understanding of the mechanisms responsible for the spread of cells from the breast to distant sites, including lymph nodes, bone, brain, liver and lungs. A variety of in vitro and in vivo models have been developed to study the biology of metastasis.(2) In general, in vitro assays have been designed to model distinct steps in the process, for example, invasion through the reconstituted basement membranes,(3) or specific binding to endothelial cells isolated from organs where the cancer cells commonly form metastases.(4,5) Such in vitro assays have great practical value for evaluating specific tumor cell behaviors, yet their limitations for predicting in vivo malignancy should always be considered. It is probably impossible to simulate accurately all the events of the metastatic process with in vitro models, especially considering the events that involve interactions with components of the microenvironment at the site of metastasis.(6) Thus, animal models using transplantable tumors that can grow and metastasize predictably in a suitable host have become standard systems for analyzing the metastatic phenotype and testing the efficacy of anti-metastatic therapies. The most common animal models are rodent tumor models, using transplantable tumors, or spontaneously arising or carcinogeninduced mammary tumors of rats and mice.(7) More recently, transgenic mice with different oncogenes targeted to the mammary epithelium have become available and some are suitable for testing specific forms of therapy, such as those designed for tumors that overexpress HER2/neu.(8,9) Immunodeficient rodents, most commonly athymic (also known as nude) of SCID mice, have been used widely for xenograft studies with human cancers. Not all human cancers or established tumor cell lines will successfully grow in immunodeficient mice, at least from a subcutaneous (s.c.) route of inoculation, the most common and for practical purposes the easiest technique to use. The approach of injecting human tumor cells into the normal equivalent mouse organ, known as orthotopic injection, has been adopted as a way to improve tumor take and growth, and has also been shown to increase Despite advances in surgical and clinical management, metastatic disease, notably to the lungs, liver, bone, and brain is the most common cause of death from breast cancer. Two basic principles govern the process of metastasis. First, that the tumors are heterogeneous populations of cells, and second, that the process of metastasis is a sequence of events that depends on tumor cell properties and interactions with the microenvironment at the sites of metastasis. In theory,
{"title":"Advances in Clinically Relevant Metastatic Breast Cancer Models","authors":"L. Kim, J. Price","doi":"10.4048/JKBCS.2004.7.3.141","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.3.141","url":null,"abstract":"Once breast cancer has been diagnosed, the most important question is whether the cancer is confined to the breast or has spread to distant sites. The majority of the death of women with breast cancer result from the growth of metastases that do not respond to therapy.(1) The development of more effective therapies should be based on a better understanding of the mechanisms responsible for the spread of cells from the breast to distant sites, including lymph nodes, bone, brain, liver and lungs. A variety of in vitro and in vivo models have been developed to study the biology of metastasis.(2) In general, in vitro assays have been designed to model distinct steps in the process, for example, invasion through the reconstituted basement membranes,(3) or specific binding to endothelial cells isolated from organs where the cancer cells commonly form metastases.(4,5) Such in vitro assays have great practical value for evaluating specific tumor cell behaviors, yet their limitations for predicting in vivo malignancy should always be considered. It is probably impossible to simulate accurately all the events of the metastatic process with in vitro models, especially considering the events that involve interactions with components of the microenvironment at the site of metastasis.(6) Thus, animal models using transplantable tumors that can grow and metastasize predictably in a suitable host have become standard systems for analyzing the metastatic phenotype and testing the efficacy of anti-metastatic therapies. The most common animal models are rodent tumor models, using transplantable tumors, or spontaneously arising or carcinogeninduced mammary tumors of rats and mice.(7) More recently, transgenic mice with different oncogenes targeted to the mammary epithelium have become available and some are suitable for testing specific forms of therapy, such as those designed for tumors that overexpress HER2/neu.(8,9) Immunodeficient rodents, most commonly athymic (also known as nude) of SCID mice, have been used widely for xenograft studies with human cancers. Not all human cancers or established tumor cell lines will successfully grow in immunodeficient mice, at least from a subcutaneous (s.c.) route of inoculation, the most common and for practical purposes the easiest technique to use. The approach of injecting human tumor cells into the normal equivalent mouse organ, known as orthotopic injection, has been adopted as a way to improve tumor take and growth, and has also been shown to increase Despite advances in surgical and clinical management, metastatic disease, notably to the lungs, liver, bone, and brain is the most common cause of death from breast cancer. Two basic principles govern the process of metastasis. First, that the tumors are heterogeneous populations of cells, and second, that the process of metastasis is a sequence of events that depends on tumor cell properties and interactions with the microenvironment at the sites of metastasis. In theory,","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123512784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-09-01DOI: 10.4048/JKBCS.2004.7.3.174
Jae Sul Lee, Y. Bae
여성에 있어서 유방은 남성과는 달리 아름다움의 상징 이며 기능면에서도 육아 시 수유 등을 담당하므로, 없어 서는 안 될 중요한 장기이다. 유방 질환은 여성 질환 중 큰 비중을 차지하고 있으며 질병에 대한 인식도가 높아짐 에 따라 유방의 종괴 촉지를 주소로 내원하는 환자의 수 가 증가하는 추세이다. 유방암은 서양에서는 여성의 가장 흔한 암으로 보고되고 있으며, “2001 한국 중앙 암 연례 등록 보고서”에 따르면 자궁암, 위암을 제치고 발생률에 있어서 1위를 차지하였다.(1) 이는 최근 경제적 성장과 더 불어 생활양식의 서구화에 기인한 것으로 여겨진다. 삶의 질에 대한 관심이 고조되면서 유방암에 대한 수술 방법도 다양하게 변화하고 있으며, 최근에는 유방보존수술이 기 존의 근치 유방절제술이나 변형 근치 유방절제술을 대체 하고 있는 추세이다. 저자들은 유방암의 수술적 치료에 관한 국내의 여러 임상고찰 논문들에서 보여지는 것보다 상당히 높은 비율로, 또한 매우 적극적으로 유방보존수술 을 시행하고 있다. 이에 저자는 2001년 1월부터 2002년 12 월까지 만 2년간 부산대학교 병원 외과에서 유방암으로 진단되어 수술한 환자 323명을 대상으로 임상적 고찰을 시행하여 그 치료 성적을 보고하는 바이다.
{"title":"Clinical Analysis of Breast Cancer Patients Treated with Surgery","authors":"Jae Sul Lee, Y. Bae","doi":"10.4048/JKBCS.2004.7.3.174","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.3.174","url":null,"abstract":"여성에 있어서 유방은 남성과는 달리 아름다움의 상징 이며 기능면에서도 육아 시 수유 등을 담당하므로, 없어 서는 안 될 중요한 장기이다. 유방 질환은 여성 질환 중 큰 비중을 차지하고 있으며 질병에 대한 인식도가 높아짐 에 따라 유방의 종괴 촉지를 주소로 내원하는 환자의 수 가 증가하는 추세이다. 유방암은 서양에서는 여성의 가장 흔한 암으로 보고되고 있으며, “2001 한국 중앙 암 연례 등록 보고서”에 따르면 자궁암, 위암을 제치고 발생률에 있어서 1위를 차지하였다.(1) 이는 최근 경제적 성장과 더 불어 생활양식의 서구화에 기인한 것으로 여겨진다. 삶의 질에 대한 관심이 고조되면서 유방암에 대한 수술 방법도 다양하게 변화하고 있으며, 최근에는 유방보존수술이 기 존의 근치 유방절제술이나 변형 근치 유방절제술을 대체 하고 있는 추세이다. 저자들은 유방암의 수술적 치료에 관한 국내의 여러 임상고찰 논문들에서 보여지는 것보다 상당히 높은 비율로, 또한 매우 적극적으로 유방보존수술 을 시행하고 있다. 이에 저자는 2001년 1월부터 2002년 12 월까지 만 2년간 부산대학교 병원 외과에서 유방암으로 진단되어 수술한 환자 323명을 대상으로 임상적 고찰을 시행하여 그 치료 성적을 보고하는 바이다.","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127492716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-09-01DOI: 10.4048/JKBCS.2004.7.3.161
Tae Hyoung Kim, Jun Hyun Lee, H. Seo, Ki Hwan Kim, J. Kim, C. An, W. Park, B. Song, S. Oh, S. Jung, K. W. Lim, Jeong soo Kim
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