Pub Date : 2004-03-01DOI: 10.4048/JKBCS.2004.7.1.32
Sung Bong Yoo, W. Park, Hyung-Sun Son, H. Jeon, Jai Hak Lee
{"title":"The Clinical Usefulness of 99mTc-MIBI Scintimammography in Diagnosis of Breast Cancer","authors":"Sung Bong Yoo, W. Park, Hyung-Sun Son, H. Jeon, Jai Hak Lee","doi":"10.4048/JKBCS.2004.7.1.32","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.1.32","url":null,"abstract":"","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125523328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-03-01DOI: 10.4048/JKBCS.2004.7.1.17
B. Son, Taekyoon Lee, S. W. Lee, U. Hwang, B. Kwak, S. Ahn
Increasing use of adjuvant postmastectomy radiation thePurpose: This study evaluated the benefit of radiation therapy in high-risk breast cancer patients who have received immediate transverse rectus abdominis myocutaneous (TRAM) flap reconstruction. The evaluation involved examining the effect of radiation therapy on postmastectomy flap fat necrosis and tumor recurrence. Methods: A retrospective review was performed on 102 patients who underwent mastectomy and immediate TRAM flap reconstruction between 1996 and 2001 at the Asan Medical Center (Seoul, Korea). The mean patient age was 41 years, and the median follow-up time was 33 months. Skin-sparing mastectomy was con ducted in 82 patients (80.4%) and classical mastectomy in 20 patients (19.6%). Of the 21 high-risk patients needing postmastectomy radiation therapy, nine received it. Results: Moderate or severe TRAM flap fat necrosis occurred more frequently in patients receiving radiation therapy than those not receiving radiation therapy (55.6% vs. 19.4%, P=0.026). In the group with high-risk patients, two tumor recurrences occurred (one-locoregional and onesystemic). Among the 102 patients, thirteen had recurrences, including only two high-risk patients, with almost of them being systemic recurrences except four locoregional recurrences. Conclusion: Our findings showed that radiation therapy increased flap fat necrosis in high-risk patients underwent immediate TRAM flap reconstruction. Such necrosis can result in poor outcomes for reconstruction. We recommend Increase of Fat Necrosis after Radiation Therapy Following Mastectomy and
目的:本研究评价放疗对高危乳腺癌患者行立即腹直肌肌瓣重建的益处。评估包括检查放射治疗对乳房切除术后皮瓣脂肪坏死和肿瘤复发的影响。方法:回顾性分析1996年至2001年间在韩国首尔峨山医疗中心接受乳房切除术并立即行TRAM皮瓣重建的102例患者。患者平均年龄41岁，中位随访时间33个月。保皮乳房切除术82例(80.4%)，经典乳房切除术20例(19.6%)。在21名需要乳房切除术后放射治疗的高危患者中，有9人接受了放射治疗。结果:中重度TRAM皮瓣脂肪坏死在放疗组发生率高于未放疗组(55.6% vs. 19.4%， P=0.026)。在高危患者组中，发生了两次肿瘤复发(一次局部和一次全身)。102例患者中有13例复发，其中高危患者仅有2例，除4例局部复发外，其余均为全身复发。结论:放疗增加了高危患者立即行TRAM皮瓣重建的皮瓣脂肪坏死。这种坏死可导致重建的不良结果。我们建议乳房切除术后放射治疗后脂肪坏死增加
{"title":"Increase of Fat Necrosis after Radiation Therapy Following Mastectomy and Immediate TRAM Flap Reconstruction in High-risk Breast Cancer Patients","authors":"B. Son, Taekyoon Lee, S. W. Lee, U. Hwang, B. Kwak, S. Ahn","doi":"10.4048/JKBCS.2004.7.1.17","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.1.17","url":null,"abstract":"Increasing use of adjuvant postmastectomy radiation thePurpose: This study evaluated the benefit of radiation therapy in high-risk breast cancer patients who have received immediate transverse rectus abdominis myocutaneous (TRAM) flap reconstruction. The evaluation involved examining the effect of radiation therapy on postmastectomy flap fat necrosis and tumor recurrence. Methods: A retrospective review was performed on 102 patients who underwent mastectomy and immediate TRAM flap reconstruction between 1996 and 2001 at the Asan Medical Center (Seoul, Korea). The mean patient age was 41 years, and the median follow-up time was 33 months. Skin-sparing mastectomy was con ducted in 82 patients (80.4%) and classical mastectomy in 20 patients (19.6%). Of the 21 high-risk patients needing postmastectomy radiation therapy, nine received it. Results: Moderate or severe TRAM flap fat necrosis occurred more frequently in patients receiving radiation therapy than those not receiving radiation therapy (55.6% vs. 19.4%, P=0.026). In the group with high-risk patients, two tumor recurrences occurred (one-locoregional and onesystemic). Among the 102 patients, thirteen had recurrences, including only two high-risk patients, with almost of them being systemic recurrences except four locoregional recurrences. Conclusion: Our findings showed that radiation therapy increased flap fat necrosis in high-risk patients underwent immediate TRAM flap reconstruction. Such necrosis can result in poor outcomes for reconstruction. We recommend Increase of Fat Necrosis after Radiation Therapy Following Mastectomy and","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123200106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-03-01DOI: 10.4048/JKBCS.2004.7.1.22
Y. Jung, Ho-Seung Kim, T. Yoon, M. Jeon, Y. Yoon, Y. Lee, Kitty Lee, Hyelim Kim, M. Kim, H. Park
Purpose: Early detection and treatment of cancer is a primary focus of health care. Many serum markers are available for breast cancer, but are not good enough for screening. Cancer antigen CA 15-3 is the most widely used biomarker for breast cancer. However, CA 15-3 has low sensitivity and specificity. This study was performed to analyze the serum proteomic pattern in breast cancer patients by surface-enhanced laser desoption/ionization timeof-flight (SELDI-TOF). Methods: We screened for potential tumor biomarkers in 42 serum samples, including samples from a group of 23 breast cancer patients at different clinical stages [stage I (n=3), stage II (n=11), stage III (n=6), and stage IV (n=1)], and a control group of 19 healthy women. Diluted serum samples were applied to a C16 hydrophobic interaction chip (H4). Complex protein profiles of different groups were compared and analyzed using the Protein Chip software 2.1 (Ciphergen Biosystems). Results: There were 7 significant protein peaks in the breast cancer group and 5 in the control group. Scoring the expression of each peak, the mean score was 8.5 in the cancer group and 3.5 in the control. The results of the combination of each peak were highly sensitive (91.2%) and specific (94.7%). These proteomic patterns did not correlate with tumor stage and hormonal receptor, c-erb B2. Conclusion: In this preliminary report, we identified protein profiles that were differentiated in breast cancer patients. After proper validation, serum proteomic pattern analysis may ultimately be applied in screening breast cancer as a stand-alone or combined with current options. (Journal of Korean Breast Cancer Society 2004;7:22-26) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
{"title":"Research of New Biomarker for Breast Cancer Using Proteomic Patterns","authors":"Y. Jung, Ho-Seung Kim, T. Yoon, M. Jeon, Y. Yoon, Y. Lee, Kitty Lee, Hyelim Kim, M. Kim, H. Park","doi":"10.4048/JKBCS.2004.7.1.22","DOIUrl":"https://doi.org/10.4048/JKBCS.2004.7.1.22","url":null,"abstract":"Purpose: Early detection and treatment of cancer is a primary focus of health care. Many serum markers are available for breast cancer, but are not good enough for screening. Cancer antigen CA 15-3 is the most widely used biomarker for breast cancer. However, CA 15-3 has low sensitivity and specificity. This study was performed to analyze the serum proteomic pattern in breast cancer patients by surface-enhanced laser desoption/ionization timeof-flight (SELDI-TOF). Methods: We screened for potential tumor biomarkers in 42 serum samples, including samples from a group of 23 breast cancer patients at different clinical stages [stage I (n=3), stage II (n=11), stage III (n=6), and stage IV (n=1)], and a control group of 19 healthy women. Diluted serum samples were applied to a C16 hydrophobic interaction chip (H4). Complex protein profiles of different groups were compared and analyzed using the Protein Chip software 2.1 (Ciphergen Biosystems). Results: There were 7 significant protein peaks in the breast cancer group and 5 in the control group. Scoring the expression of each peak, the mean score was 8.5 in the cancer group and 3.5 in the control. The results of the combination of each peak were highly sensitive (91.2%) and specific (94.7%). These proteomic patterns did not correlate with tumor stage and hormonal receptor, c-erb B2. Conclusion: In this preliminary report, we identified protein profiles that were differentiated in breast cancer patients. After proper validation, serum proteomic pattern analysis may ultimately be applied in screening breast cancer as a stand-alone or combined with current options. (Journal of Korean Breast Cancer Society 2004;7:22-26) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129914180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-12-01DOI: 10.4048/JKBCS.2003.6.4.303
Hai‐Lin Park, J. Kwak, Sang Dal Lee, S. Nam, Jung-Hyun Yang
Purpose: Male breast cancer is a rare type of neoplasm, account for 1 % of all breast tumors. A retrospective review of the clinical and histological characteristics, types of treatment, pathological staging, and adjuvant treatment was completed. The objective of this study was to make an early diagnosis of male breast cancer and reduce the mortality. Methods: Over a 5-year period, from Oct. 1994 to July 2000, 10 male breast cancer patients were operated on in the breast cancer clinic of the Samsung Medical Center. Their duration of follow up ranged from 6 to 76 months with a mean of 26 months. The clinical and histological characteristics, associations of the risk factors, type of treatment, and results were studied. Results: Their ages ranged from 40 to 67 years with a mean of 51 years, with 5, 3 and 2 cases in their 5th, 6th, and 7th decades, respectively. A palpable breast lump was the most common presenting symptom. A pathological assessment disclosed 8 infiltrating ductal carcinoma, 1 ductal carcinoma in situ, and 1 invasive adenoid cystic carcinoma. The tumor sizes ranged from 0.5 to 3.7 cm (median, 1.9 cm in diameter). Of the 10 patients, there were 3 T1b, 3 T1c, and 4 T2 in the tumor staging. 4 Patients had axillary node involvement (lymph node positivity, 40%), and of these 4, the metastasis involved 2 lymph nodes and more than 3 lymph nodes in 1 and 3 case, respectively. No distant metastasis was observed in any of the patients. Pathological stages of the patients 0, I, IIIA, and IIIB in 1, 5, 1 and 2 cases, respectively. All the patients underwent surgery, 7 with a modified radical mastectomy and 3 with a radical mastectomy, due to gross invasion of the pectoralis major muscle. Conclusion: A subareolar palpable breast mass was the most common presenting symptom of the male breast cancer patients. The optimal treatment for male breast cancer patients is a modified radical mastectomy, combined with radiotherapy, chemotherapy, and hormonal therapy, due to the higher hormone receptors positivity. (Journal of Korean Breast Cancer Society 2003;6:303-307)
{"title":"Male Breast Cancer-10 Cases","authors":"Hai‐Lin Park, J. Kwak, Sang Dal Lee, S. Nam, Jung-Hyun Yang","doi":"10.4048/JKBCS.2003.6.4.303","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.4.303","url":null,"abstract":"Purpose: Male breast cancer is a rare type of neoplasm, account for 1 % of all breast tumors. A retrospective review of the clinical and histological characteristics, types of treatment, pathological staging, and adjuvant treatment was completed. The objective of this study was to make an early diagnosis of male breast cancer and reduce the mortality. Methods: Over a 5-year period, from Oct. 1994 to July 2000, 10 male breast cancer patients were operated on in the breast cancer clinic of the Samsung Medical Center. Their duration of follow up ranged from 6 to 76 months with a mean of 26 months. The clinical and histological characteristics, associations of the risk factors, type of treatment, and results were studied. Results: Their ages ranged from 40 to 67 years with a mean of 51 years, with 5, 3 and 2 cases in their 5th, 6th, and 7th decades, respectively. A palpable breast lump was the most common presenting symptom. A pathological assessment disclosed 8 infiltrating ductal carcinoma, 1 ductal carcinoma in situ, and 1 invasive adenoid cystic carcinoma. The tumor sizes ranged from 0.5 to 3.7 cm (median, 1.9 cm in diameter). Of the 10 patients, there were 3 T1b, 3 T1c, and 4 T2 in the tumor staging. 4 Patients had axillary node involvement (lymph node positivity, 40%), and of these 4, the metastasis involved 2 lymph nodes and more than 3 lymph nodes in 1 and 3 case, respectively. No distant metastasis was observed in any of the patients. Pathological stages of the patients 0, I, IIIA, and IIIB in 1, 5, 1 and 2 cases, respectively. All the patients underwent surgery, 7 with a modified radical mastectomy and 3 with a radical mastectomy, due to gross invasion of the pectoralis major muscle. Conclusion: A subareolar palpable breast mass was the most common presenting symptom of the male breast cancer patients. The optimal treatment for male breast cancer patients is a modified radical mastectomy, combined with radiotherapy, chemotherapy, and hormonal therapy, due to the higher hormone receptors positivity. (Journal of Korean Breast Cancer Society 2003;6:303-307)","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131136778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-12-01DOI: 10.4048/JKBCS.2003.6.4.277
Hyuck Song, T. Koo, Ji Hoon Park, K. Song, Sung Tae Kim, I. Choi, W. Choi, W. K. Mok, H. Min, D. Yoon
2001년 보건복지부 암등록 보고에 의하면 유방암은 우 리나라 여성암 중에서 첫 번째로 발생빈도가 높은 암으로 점차 발생빈도가 증가추세를 보이고 있어 유방암의 조기 발견과 예방 및 치료에 많은 연구가 필요하다.(1) 최근에 cyclooxygenase (이하 Cox) 효소의 발현이 악성조직의 병 태생리와 연관이 있는 것으로 보고되고 있으며, Aspirin과 같은 non-steroidal anti-inflammatory drug (NSAID)를 사용하 여 Cox의 발현을 억제함으로써 암 발생 빈도를 감소시킬 수 있다고 보고되고 있다. Cox는 Cox-1과 Cox-2의 두 가 지의 isoenzyme의 형태가 존재하며 60%의 동일한 염기 배 열을 갖고 있다.(2-4) Cox-1은 체내에서 정상적으로 발현 되어 생리학적 반응을 조절하는 역할을 하는 데 비해 Cox-2 는 proinflammatory agent 등에 의해 발현이 증가되어 체내 의 병리학적 반응에 관여한다. Cox-2는 growth factor, inflammatory cytokine, endotoxin 등에 의해 종양세포에서 발 현이 유발되며, 특히 vascular endothelial growth factor (VEGF) 와 함께 종양세포에서 과다 발현되어 종양발생기전에 깊 은 관계가 있다고 알려지고 있다. 대장암,(5) 폐암,(6) 위 암,(7) 전립선암,(8) 췌장암(9) 등에서 Cox-2의 발현증가가 보고되었고, 저자들의 선행 연구에서 Cox-2의 발현이 양 성조직(섬유선종, 유관 내 유두종, 여성형 유방, 섬유 낭종 성 변성)보다 유방암 조직에서 현저하게 증가되있음을 보 고한 바 있다.(10) 이는 Cox-2의 과발현이 유방암 발생 과 정 중 하나의 관련 인자로서 역할을 담당하고 있음을 알 수 있다. 저자들은 유방암에서 Cox-2가 과발현하는 것에 기초하 여 selective Cox-2 inhibitor (NS-398)와 genistein의 유방암 세포 주에서의 Cox-2 mRNA 발현에 미치는 효과를 역전 사-중합효소연쇄반응(RT-PCR)을 이용하여 비교하였다. 본 연구의 궁극적인 목적은 유방암 발생 빈도가 상대적으로 낮은 한국인의 전통식이 중 콩에 함유된 isoflavone phytoestrogen (genistein)이 Cox-2 억제를 통해 유방암 발생을 억제할 수 있다는 가설을 증명하고자 하였다. 책임저자:윤대성, 대전시 서구 가수원동 685번지 ꂕ 302-718, 건양대학교병원 외과학교실 Tel: 042-600-9140, Fax: 042-542-0133 E-mail: dsyoonmd@kyuh.co.kr 접수일:2003년 10월 21일, 게재승인일:2003년 12월 18일 본 논문은 2003년 춘계 한국 유방암학회에서 구연되었음. Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line
保健福利部根据癌症登记报告,2001年乳腺癌李娜上面,而是在女性癌症中第一家在高频率逐步癌症发病频率呈现出增加趋势,因此,对乳腺癌的早期发现和预防及治疗需要很多研究。(1)最近cyclooxygenase(以下cox)的酶的发现恶性组织的胎生和病有关联的报告,有报告称，使用Aspirin等non-steroidal anti-inflammatory drug (NSAID)抑制Cox的发现，可以减少癌症发生频率。Cox存在Cox-1和Cox-2两种支的isoenzyme形态，具有60%的相同碱排列。(2-4)Cox-1在体内正常表达，起到调节生理学反应的作用，而Cox-2通过proinflammatory agent等增加表达，参与体内的病理反应。Cox-2通过growth factor、inflammatory cytokine、endotoxin等在肿瘤细胞中出现，特别是与vascular endothelial growth factor (VEGF)在肿瘤细胞中表现过多，与肿瘤发生前有很深的关系。大肠癌、(5)肺癌、(6)胃癌、(7)前列腺癌、(8)胰腺癌(9)等都发现了Cox-2的发现。在作者的先行研究中，发现了两性组织(纤维腺瘤、乳管内乳头瘤、女性乳房;(10)表明Cox-2的过发现作为乳房癌发生过程中的一个相关因子起着作用。作者在乳腺癌Cox-2过表达的基础上，用逆转录-聚合酶链反应(RT-PCR)比较了selective Cox-2 inhibitor (NS-398)和genistein对乳腺癌细胞株Cox-2 mRNA表达的效果。本研究的最终目的是为了证明在乳房癌发生频率相对较低的韩国人的传统饮食中，大豆中含有的isoflavone phytoestrogen (genistein)可以通过Cox-2抑制乳房癌发生的假说。责任作者:尹大省,大田市西区歌手远东685号教室ꂕ302 - 718,건양대학교医院整形科tel: 042 - 600 - 9140, fax: 042 - 542 - 0133 e - mail: dsyoonmd @ kyuh . co . kr接收日:2003年10月21日,刊登日:2003年12月18日承认本论文从2003年的春季韩国乳腺癌学会曲艺已。Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line
{"title":"Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line","authors":"Hyuck Song, T. Koo, Ji Hoon Park, K. Song, Sung Tae Kim, I. Choi, W. Choi, W. K. Mok, H. Min, D. Yoon","doi":"10.4048/JKBCS.2003.6.4.277","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.4.277","url":null,"abstract":"2001년 보건복지부 암등록 보고에 의하면 유방암은 우 리나라 여성암 중에서 첫 번째로 발생빈도가 높은 암으로 점차 발생빈도가 증가추세를 보이고 있어 유방암의 조기 발견과 예방 및 치료에 많은 연구가 필요하다.(1) 최근에 cyclooxygenase (이하 Cox) 효소의 발현이 악성조직의 병 태생리와 연관이 있는 것으로 보고되고 있으며, Aspirin과 같은 non-steroidal anti-inflammatory drug (NSAID)를 사용하 여 Cox의 발현을 억제함으로써 암 발생 빈도를 감소시킬 수 있다고 보고되고 있다. Cox는 Cox-1과 Cox-2의 두 가 지의 isoenzyme의 형태가 존재하며 60%의 동일한 염기 배 열을 갖고 있다.(2-4) Cox-1은 체내에서 정상적으로 발현 되어 생리학적 반응을 조절하는 역할을 하는 데 비해 Cox-2 는 proinflammatory agent 등에 의해 발현이 증가되어 체내 의 병리학적 반응에 관여한다. Cox-2는 growth factor, inflammatory cytokine, endotoxin 등에 의해 종양세포에서 발 현이 유발되며, 특히 vascular endothelial growth factor (VEGF) 와 함께 종양세포에서 과다 발현되어 종양발생기전에 깊 은 관계가 있다고 알려지고 있다. 대장암,(5) 폐암,(6) 위 암,(7) 전립선암,(8) 췌장암(9) 등에서 Cox-2의 발현증가가 보고되었고, 저자들의 선행 연구에서 Cox-2의 발현이 양 성조직(섬유선종, 유관 내 유두종, 여성형 유방, 섬유 낭종 성 변성)보다 유방암 조직에서 현저하게 증가되있음을 보 고한 바 있다.(10) 이는 Cox-2의 과발현이 유방암 발생 과 정 중 하나의 관련 인자로서 역할을 담당하고 있음을 알 수 있다. 저자들은 유방암에서 Cox-2가 과발현하는 것에 기초하 여 selective Cox-2 inhibitor (NS-398)와 genistein의 유방암 세포 주에서의 Cox-2 mRNA 발현에 미치는 효과를 역전 사-중합효소연쇄반응(RT-PCR)을 이용하여 비교하였다. 본 연구의 궁극적인 목적은 유방암 발생 빈도가 상대적으로 낮은 한국인의 전통식이 중 콩에 함유된 isoflavone phytoestrogen (genistein)이 Cox-2 억제를 통해 유방암 발생을 억제할 수 있다는 가설을 증명하고자 하였다. 책임저자:윤대성, 대전시 서구 가수원동 685번지 ꂕ 302-718, 건양대학교병원 외과학교실 Tel: 042-600-9140, Fax: 042-542-0133 E-mail: dsyoonmd@kyuh.co.kr 접수일:2003년 10월 21일, 게재승인일:2003년 12월 18일 본 논문은 2003년 춘계 한국 유방암학회에서 구연되었음. Inhibition of Cyclooxygenase-2 (Cox-2) Expression by Genistein in Breast Cancer Cell-line","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115123411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-12-01DOI: 10.4048/JKBCS.2003.6.4.291
J. Lim
암의 조기 발견을 위해서 유방도 일정 간격으로 정 기검진을 권유하고 있으며 한국유방암학회에서도 정기 검진 권유 안을 발표했다. 35세까지는 자가 검진, 40세 까지는 의사에 의한 유방검진, 40세 이후에는 1∼2년 간격으로 유방촬영으로 정기검진을 권유한다. 하지만 규칙적인 정기 검진에도 불구하고 검진기간 사이에 암 이 발생하기도 한다. 이러한 간격 암(interval breast cancer) 의 원인은 다양하며, 발생을 줄이는 것은 유방암 검진 기관의 최대 목표가 된다. 정기검진 중간에 발견된 암 의 원인으로는 원래 있었던 암을 놓친 경우(missed cancer), 검사상의 위음성(false negative), 간격 암 등으로 세 분한다. 그러나 본 논문은 간격 암을 분석하고 원인을 밝힘으로써 발생을 줄이는 데 그 목적이 있으므로 본 논문에서는 이러한 구분을 하지 않았고, 본 병원에서 주기적인 정기 검진을 하면서 이전 검진 이후 24개월 이내에 본 병원에서 암을 발견한 경우를 전부 포함시 켰다.
为了早期发现癌症，建议对乳房也以一定的间隔进行定期检查，韩国乳房癌学会也发表了定期检查劝告案。35岁之前进行自我检查，40岁之前由医生进行乳房检查，40岁以后以1 ~ 2年为间隔进行定期检查。但是，即使有规律的定期检查，也会在检查期间发生癌症。这种间隔癌(interval breast cancer)的原因是多种多样的，减少发病率是乳房癌检查机构的最大目标。在定期检查过程中发现的癌症分为“错过原来的癌症(missed cancer)”、“检查上的胃阴性(false negative)”、“间隔癌”等3种。但是本文分析癌症间隔,表示原因”,从而减少发生的,其目的,本论文在没有这种区分,在本医院周期性,定期体检之前体检之后24个月之内在本医院发现癌症的情况全部纳入。
{"title":"Interval Breast Cancer","authors":"J. Lim","doi":"10.4048/JKBCS.2003.6.4.291","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.4.291","url":null,"abstract":"암의 조기 발견을 위해서 유방도 일정 간격으로 정 기검진을 권유하고 있으며 한국유방암학회에서도 정기 검진 권유 안을 발표했다. 35세까지는 자가 검진, 40세 까지는 의사에 의한 유방검진, 40세 이후에는 1∼2년 간격으로 유방촬영으로 정기검진을 권유한다. 하지만 규칙적인 정기 검진에도 불구하고 검진기간 사이에 암 이 발생하기도 한다. 이러한 간격 암(interval breast cancer) 의 원인은 다양하며, 발생을 줄이는 것은 유방암 검진 기관의 최대 목표가 된다. 정기검진 중간에 발견된 암 의 원인으로는 원래 있었던 암을 놓친 경우(missed cancer), 검사상의 위음성(false negative), 간격 암 등으로 세 분한다. 그러나 본 논문은 간격 암을 분석하고 원인을 밝힘으로써 발생을 줄이는 데 그 목적이 있으므로 본 논문에서는 이러한 구분을 하지 않았고, 본 병원에서 주기적인 정기 검진을 하면서 이전 검진 이후 24개월 이내에 본 병원에서 암을 발견한 경우를 전부 포함시 켰다.","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123907758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-12-01DOI: 10.4048/JKBCS.2003.6.4.263
H. Lee, Jin Wook Choi, Do Yil Kim, Byeong-Woo Park, I. Lee, H. Song, W. Jung, Hee Jung Kim, Y. H. Ryu, K. Oh
Purpose: This study was performed to evaluate the efficacy and safety of sentinel lymph node biopsy alone (SLNB) without axillary lymph node dissection. Methods: Between Jun. 1999 and Dec. 2002, we carried out SLNB in 85 consecutive patients with T1 breast cancer whose sentinel lymph node(s) were tumor-free on intraoperative frozen section. Even when sentinel lymph node(s) turned out to be positive by permanent pathology, additional axillary lymph node dissection was not performed. Patients underwent total mastectomy or partial mastectomy and received an appropriate adjuvant therapy according to the characteristics of the primary tumor. All patients who had breast conserving surgery received postoperative radiotherapy to the remaining breast, but not to the axilla. Results: SLNB only took 14 minutes and yielded no postoperative complications. Among the 85 patients whose sentinel lymph nodes were tumor-free on frozen section, 11 patients were diagnosed as metastatic in the permanent pathology. One of them had a macro-metastasized (2.5 cm) sentinel lymph node, and the rest had micro-metastasized sentinel lymph nodes. For 23.1 months of mean follow-up period, all the patients including a patient who died of liver metastases at 17 months showed no evidence of axillary recurrence. Conclusion: No axillary recurrence following SLNB suggests that SLNB may be a good alternative to routine axillary lymph node dissection while providing less surgical morbidity in women with a small breast cancer. However, more patients accumulation and follow-up period will be needed for the final conclusion. (Journal of Korean Breast Cancer Society 2003;6:263-270) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
{"title":"Clinical Experience for Sentinel Lymphadenectomy Alone in Early Breast Cancer","authors":"H. Lee, Jin Wook Choi, Do Yil Kim, Byeong-Woo Park, I. Lee, H. Song, W. Jung, Hee Jung Kim, Y. H. Ryu, K. Oh","doi":"10.4048/JKBCS.2003.6.4.263","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.4.263","url":null,"abstract":"Purpose: This study was performed to evaluate the efficacy and safety of sentinel lymph node biopsy alone (SLNB) without axillary lymph node dissection. Methods: Between Jun. 1999 and Dec. 2002, we carried out SLNB in 85 consecutive patients with T1 breast cancer whose sentinel lymph node(s) were tumor-free on intraoperative frozen section. Even when sentinel lymph node(s) turned out to be positive by permanent pathology, additional axillary lymph node dissection was not performed. Patients underwent total mastectomy or partial mastectomy and received an appropriate adjuvant therapy according to the characteristics of the primary tumor. All patients who had breast conserving surgery received postoperative radiotherapy to the remaining breast, but not to the axilla. Results: SLNB only took 14 minutes and yielded no postoperative complications. Among the 85 patients whose sentinel lymph nodes were tumor-free on frozen section, 11 patients were diagnosed as metastatic in the permanent pathology. One of them had a macro-metastasized (2.5 cm) sentinel lymph node, and the rest had micro-metastasized sentinel lymph nodes. For 23.1 months of mean follow-up period, all the patients including a patient who died of liver metastases at 17 months showed no evidence of axillary recurrence. Conclusion: No axillary recurrence following SLNB suggests that SLNB may be a good alternative to routine axillary lymph node dissection while providing less surgical morbidity in women with a small breast cancer. However, more patients accumulation and follow-up period will be needed for the final conclusion. (Journal of Korean Breast Cancer Society 2003;6:263-270) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124563308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-12-01DOI: 10.4048/JKBCS.2003.6.4.296
Seung Soo Lee, J. Jung, H. Park, Young Ha Lee, S. Lee, Yun Kyeong Son
Purpose: The aim of this study was to achieve early detection, accurate diagnosis and adequate management of suspicious non-palpable breast lesions. Methods: From January 1998 to March 2002, 86 cases of ultrasonoguided needle biopsies, 121 cases of mammographically guided needle localization biopsies and 75 cases of ultrasonographically guided needle localization biospsies were performed for a total of 282 cases of nonpalpable breast lesions. Results: The age of patients ranged from 30 to 71 years with a mean age of 46.4 years. 56 cases out of a total 282 cases (20%) were found to be malignant (39.3% of those malignancies were carcinomas in situ, and 60.7% were invasive carcinomas). On a mammogram, 15.1% of the microcalcifications were found to be malignant. 31.6% of mass-like lesions and 20% of masses with microcalcifications were found to be malignant. On an ultrasonogram, 42.7% of the microcalcifications were found to be malignant. 21.1% of mass-like lesions, 30% of intraductal masses, and 31.6% of masses with microcalcifications were found to be malignant. 73.5% of all the cases of non-palpable breast cancer were found in stage 0 or 1. Conclusion: Non-palpable breast cancers are smaller in size and have lower chances of axillary lymph node involvement compared to palpable breast cancers. Because it is nonpalpable, an early diagnosis is hard to achieve. However, once an early diagnosis is made, it could result in better prognosis. Therefore, the selection of adequate diagnostic modalities, the development of better localization methods, and training of precise surgical skill are important. (Journal of Korean Breast Cancer Society 2003;6:296-302) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
{"title":"Evaluation & Management of Non-palpable Breast Lesions","authors":"Seung Soo Lee, J. Jung, H. Park, Young Ha Lee, S. Lee, Yun Kyeong Son","doi":"10.4048/JKBCS.2003.6.4.296","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.4.296","url":null,"abstract":"Purpose: The aim of this study was to achieve early detection, accurate diagnosis and adequate management of suspicious non-palpable breast lesions. Methods: From January 1998 to March 2002, 86 cases of ultrasonoguided needle biopsies, 121 cases of mammographically guided needle localization biopsies and 75 cases of ultrasonographically guided needle localization biospsies were performed for a total of 282 cases of nonpalpable breast lesions. Results: The age of patients ranged from 30 to 71 years with a mean age of 46.4 years. 56 cases out of a total 282 cases (20%) were found to be malignant (39.3% of those malignancies were carcinomas in situ, and 60.7% were invasive carcinomas). On a mammogram, 15.1% of the microcalcifications were found to be malignant. 31.6% of mass-like lesions and 20% of masses with microcalcifications were found to be malignant. On an ultrasonogram, 42.7% of the microcalcifications were found to be malignant. 21.1% of mass-like lesions, 30% of intraductal masses, and 31.6% of masses with microcalcifications were found to be malignant. 73.5% of all the cases of non-palpable breast cancer were found in stage 0 or 1. Conclusion: Non-palpable breast cancers are smaller in size and have lower chances of axillary lymph node involvement compared to palpable breast cancers. Because it is nonpalpable, an early diagnosis is hard to achieve. However, once an early diagnosis is made, it could result in better prognosis. Therefore, the selection of adequate diagnostic modalities, the development of better localization methods, and training of precise surgical skill are important. (Journal of Korean Breast Cancer Society 2003;6:296-302) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131098801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-12-01DOI: 10.4048/JKBCS.2003.6.4.308
Y. Chang, Min Huck Lee, K. Kwon, D. L. Choi, Junghwan Hwang, D. Goo, Seung Tae Park, J. H. Kim, Dong Wha Lee
인슐린 의존성 당뇨병으로 20년간 치료를 받아왔으며 당뇨병성 안증의 과거력이 있는 54세 여자 환자가 양측 유방의 만져지는 종괴를 주소로 내원하였다. 이학적 검사 에서 딱딱하나 압박을 가하면 약간의 탄력을 가지는 종괴 가 우측 유방의 상외측과 좌측 유방의 상측 중앙 부위에 서 만져졌다. 만져지는 액와부나 두경부 림프절은 없었다. 유방촬영상 균질한 고음영이 양측 유방의 상외측에 있었 으나 경계가 그려지는 종괴나 미세석회화, 조직의 변형 등의 소견은 없었다(Fig. 1A). 초음파 검사를 시행하였을 때 불규칙한 경계를 가지는 저음영의 종괴가 있었으며 후 방음영이 동반되어 있었다(Fig. 1B). 칼라 도플러 검사에 서 혈류의 증가는 없었다. MR 영상은 1.5 T기기(Magnetom, Sonota; Siemens, Erlangen, Germany)를 사용하였으며 환자는 엎드린 자세로 유방 전 용 코일을 사용하였다. 다음의 변수를 사용하였다; axial T1-weighted spin-echo sequence, axial fat-saturation T2weighted fast spin-echo sequence, 26-cm field of view, 3-mm section thickness, 1.0-mm gap, 512×256 matrix. Fast low-angle shot (FLASH) sequence를 사용하여 조영 증강 전과 조영 증강 후 60초에 영상을 얻은 후, 매 90초 간격으로 5회 반복영상을 얻었다. 조영제는 Gadodiamide (Omniscan, Nycomed, Ireland)를 사용하여 환자의 왼쪽 팔 에 bolus로 주입을 하였다. 초음파에서 저음영의 종괴를 보이던 우측 유방의 상외 측과 좌측 유방의 상측 중앙 부위에서T1 강조영상과 T2 강조영상에서 모두 저신호강도의 병변이 보였다(Fig. 1C, D). 역동적 조영증강 3차원 FLASH 영상을 시행하였을 때, 첫 60초 영상에서 거의 조영 증강이 되지 않다가 시간경 과에 따른 순차적인 조영증강이 관찰되었으며 마지막 지 연 7분 영상에서는 T1과 T2강조영상에서 저신호강도를 보였던 부위에 비균질한 조영증강을 보였다(Fig. 1E, F). 14 G 중심침 생검(core needle biopsy)이 시행되었으며 양측 유방에서 각각 조직을 얻었고 환자의 요청으로 외과적 조 직검사도 시행되었다. 병리학적 검사에서 기질의 켈로이 MR Imaging of Diabetic Mastopathy: A Case Report Yun-Woo Chang, Min Huck Lee, Kui Hyang Kwon, Duck Lin Choi, Jung Wha Hwang, Dong Erk Goo, Seung Tae Park, Jung Hoon Kim and Dong Wha Lee Departments of Diagnostic Radiology, General Surgery and Pathology, Soonchunhyang University Hospital, Seoul, Korea Diabetic mastopathy is a rare disease that occurs in longterm insulin-dependent diabetic patient. It manifests as a hard palpable breast mass that may be clinically indistinguishable from a breast carcinoma. Mammography shows a non-specific, dense, heterogenous glandular opacity in both breasts. Sonography shows a markedly hypoechoic, ill-marginated mass with a posterior acoustic shadowing. We present the mammography, ultrasonography and MRI findings of a 54-year-old woman with diabetic mastopathy. (Journal of Korean Breast Cancer Society 2003;6:308-310) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
一名54岁的女患者因胰岛素依赖性糖尿病接受了20年的治疗，有糖尿病性眼病历史，她将两侧乳房的可触摸的肿块送到了医院。在理学检查中，压迫一个硬的肿块会在右侧乳房的上外侧和左侧乳房的上侧中央部位被摸到。没有触碰的腋窝或颈部淋巴结。在乳房摄影上，均质的高高音在两侧乳房的上外侧，但没有出现画出界限的肿块、微细石灰化、组织变形等诊断(Fig)。1a)。进行超声波检查时，出现了具有不规则边界的低音铃肿块，伴有后隔音(Fig)。1b)。彩色多普勒检查中血流没有增加。MR影像为1.5吨机器(Magnetom, Sonota;使用Siemens, Erlangen, Germany)，患者以俯卧姿势使用乳房前用线圈。使用了以下变量;axial T1-weighted spin-echo sequence, axial fat-saturation T2weighted fast spin-echo sequence, 26-cm field of view, 3-mm section thickness, 1.0-mm gap, 512×256 matrix。使用Fast low-angle shot (FLASH) sequence在造影增强前和造影增强后60秒获得影像，每90秒获得5次重复影像。造形剂使用Gadodiamide (Omniscan, Nycomed, Ireland)在病人左臂上注入bolus。在超声波中显示低音铃肿块的右侧乳房上外侧和左侧乳房上侧中央部位，T1姜祚荣像和T2强调影像中都显示出低信号强度病变(Fig)。1, d)。三维动态造影增强flash视频实行了时,第一个60秒的视频中,几乎没有造影增强有效时间全警和带来的连续观察了造影增强,最后7分钟的视频中,t1和t2在强调影像信号强度显示出了我的部位非均质表现出了造影增强(fig。1E和F . 14 G中心针活检(core needle biopsy)，两侧乳房各取组织，并在患者要求下进行外科组织检查。在病理检查中，基质肌酸酐MR Imaging of Diabetic Mastopathy:A Case Report Yun-Woo Chang, Min Huck Lee, Kui Hyang Kwon, Duck Lin Choi, Jung Wha Hwang, Dong Erk Goo, Seung Tae Park, Jung Hoon Kim and Dong Wha Lee Departments of Diagnostic Radiology，General Surgery and Pathology, Soonchunhyang University Hospital, Seoul, Korea Diabetic mastopathy is a rare disease that occurs in longterm insulin-dependent Diabetic patient。It manifests as a hard palpable breast mass that may be clinically indistinguishable from a breast carcinoma。Mammography shows a non-specific, dense, heterogenous glandular opacity in both breasts。Sonography shows a markedly hypoechoic, ill-marginated mass with a posterior acoustic shadowing。我们present the mammography, ultrasonography and MRI findings of a 54-year-old woman with diabetic mastopathy。(journal of korean breast cancer society 2003; 6: 308 - 310)ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
{"title":"MR Imaging of Diabetic Mastopathy: A Case Report","authors":"Y. Chang, Min Huck Lee, K. Kwon, D. L. Choi, Junghwan Hwang, D. Goo, Seung Tae Park, J. H. Kim, Dong Wha Lee","doi":"10.4048/JKBCS.2003.6.4.308","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.4.308","url":null,"abstract":"인슐린 의존성 당뇨병으로 20년간 치료를 받아왔으며 당뇨병성 안증의 과거력이 있는 54세 여자 환자가 양측 유방의 만져지는 종괴를 주소로 내원하였다. 이학적 검사 에서 딱딱하나 압박을 가하면 약간의 탄력을 가지는 종괴 가 우측 유방의 상외측과 좌측 유방의 상측 중앙 부위에 서 만져졌다. 만져지는 액와부나 두경부 림프절은 없었다. 유방촬영상 균질한 고음영이 양측 유방의 상외측에 있었 으나 경계가 그려지는 종괴나 미세석회화, 조직의 변형 등의 소견은 없었다(Fig. 1A). 초음파 검사를 시행하였을 때 불규칙한 경계를 가지는 저음영의 종괴가 있었으며 후 방음영이 동반되어 있었다(Fig. 1B). 칼라 도플러 검사에 서 혈류의 증가는 없었다. MR 영상은 1.5 T기기(Magnetom, Sonota; Siemens, Erlangen, Germany)를 사용하였으며 환자는 엎드린 자세로 유방 전 용 코일을 사용하였다. 다음의 변수를 사용하였다; axial T1-weighted spin-echo sequence, axial fat-saturation T2weighted fast spin-echo sequence, 26-cm field of view, 3-mm section thickness, 1.0-mm gap, 512×256 matrix. Fast low-angle shot (FLASH) sequence를 사용하여 조영 증강 전과 조영 증강 후 60초에 영상을 얻은 후, 매 90초 간격으로 5회 반복영상을 얻었다. 조영제는 Gadodiamide (Omniscan, Nycomed, Ireland)를 사용하여 환자의 왼쪽 팔 에 bolus로 주입을 하였다. 초음파에서 저음영의 종괴를 보이던 우측 유방의 상외 측과 좌측 유방의 상측 중앙 부위에서T1 강조영상과 T2 강조영상에서 모두 저신호강도의 병변이 보였다(Fig. 1C, D). 역동적 조영증강 3차원 FLASH 영상을 시행하였을 때, 첫 60초 영상에서 거의 조영 증강이 되지 않다가 시간경 과에 따른 순차적인 조영증강이 관찰되었으며 마지막 지 연 7분 영상에서는 T1과 T2강조영상에서 저신호강도를 보였던 부위에 비균질한 조영증강을 보였다(Fig. 1E, F). 14 G 중심침 생검(core needle biopsy)이 시행되었으며 양측 유방에서 각각 조직을 얻었고 환자의 요청으로 외과적 조 직검사도 시행되었다. 병리학적 검사에서 기질의 켈로이 MR Imaging of Diabetic Mastopathy: A Case Report Yun-Woo Chang, Min Huck Lee, Kui Hyang Kwon, Duck Lin Choi, Jung Wha Hwang, Dong Erk Goo, Seung Tae Park, Jung Hoon Kim and Dong Wha Lee Departments of Diagnostic Radiology, General Surgery and Pathology, Soonchunhyang University Hospital, Seoul, Korea Diabetic mastopathy is a rare disease that occurs in longterm insulin-dependent diabetic patient. It manifests as a hard palpable breast mass that may be clinically indistinguishable from a breast carcinoma. Mammography shows a non-specific, dense, heterogenous glandular opacity in both breasts. Sonography shows a markedly hypoechoic, ill-marginated mass with a posterior acoustic shadowing. We present the mammography, ultrasonography and MRI findings of a 54-year-old woman with diabetic mastopathy. (Journal of Korean Breast Cancer Society 2003;6:308-310) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123655141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-12-01DOI: 10.4048/JKBCS.2003.6.4.255
D. Choi, M. H. Lee, Yongsoon Ahn, Dong Wha Lee, D. Shin, D. Carter, B. King, B. Haffty
ligand binding.(7) Over-expression of HER-2 has been shown test may be useful for selecting systemic chemotherapy in Korean patients with early onset breast cancer. And the specific anti-HER-2 therapy will be helpful to a large proportion of Korean patients who have more tumors with HER-2 overexpression than White patients. (Journal of Korean Breast Cancer Society 2003;6:255-262) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ
{"title":"Characteristics of HER-2/neu Oncogene in Korean Women with Early-onset Breast Cancer by Immunohistochemistry and Fluorescence In Situ Hybridization","authors":"D. Choi, M. H. Lee, Yongsoon Ahn, Dong Wha Lee, D. Shin, D. Carter, B. King, B. Haffty","doi":"10.4048/JKBCS.2003.6.4.255","DOIUrl":"https://doi.org/10.4048/JKBCS.2003.6.4.255","url":null,"abstract":"ligand binding.(7) Over-expression of HER-2 has been shown test may be useful for selecting systemic chemotherapy in Korean patients with early onset breast cancer. And the specific anti-HER-2 therapy will be helpful to a large proportion of Korean patients who have more tumors with HER-2 overexpression than White patients. (Journal of Korean Breast Cancer Society 2003;6:255-262) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":414717,"journal":{"name":"Journal of Korean Breast Cancer Society","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122348351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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