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Ensuring The Quality of Healthcare Services in Medicine and Dentistry: The Role of Medical Education, Regulatory Requirements and Effective Practices 确保医学和牙科保健服务的质量:医学教育的作用、监管要求和有效实践
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.37
Kamila SerikovnaSeitkazina, Malik Burzakhanov, A. Yumashev, D.V. Dokhmila, Vitaliya Marshalova, Alexander Markov
The article examines the role of medical education, regulatory requirements and effective practices in ensuring the quality of healthcare services in medical practice and dentistry. The authors indicate that these factors directly affect the quality of medical care in any country of the world. By studying the structure of the issue, the researchers identify to what extent this or that indicator has an impact on increasing patient satisfaction with the medical services provided, on increasing awareness of medical workers of the work they perform on the medical care of the population. An important role, according to the authors, is played by the results of the assimilation of educational programs by future doctors, as well as the effectiveness of their activities in internship and residency. Special emphasis is placed on the need to develop communication and ethical skills in future therapists and dentists. Regulations and standards in the field of medicine, as noted in the work, also play an important role in the organization of high-quality patient care in medical organizations of different levels. Also, various innovations in the field of digitalization of the process of providing medical services play a leading role in the field of medical care, especially in the field of therapy and dentistry. It is for this reason that the study of best practices, as well as the experience of Russian and foreign colleagues, makes it possible to expand the scope of their activities by applying innovative tools and approaches in the field of patient treatment. In general, the prospects of these areas of improving the quality of patient care in the field of dentistry and therapy will not only achieve this goal, but also increase the pace of development of these medical fields, which will favorably affect, in general, the development of domestic medicine.
本文探讨了医学教育的作用,监管要求和有效的做法,以确保医疗实践和牙科保健服务的质量。作者指出,这些因素直接影响到世界上任何一个国家的医疗质量。通过研究问题的结构,研究人员确定了这个或那个指标对提高患者对所提供的医疗服务的满意度和提高医务工作者对其在人口医疗保健方面所做工作的认识的影响程度。根据作者的说法,未来医生对教育计划的吸收结果以及他们在实习和住院医生活动的有效性发挥了重要作用。特别强调的是需要发展沟通和道德技能在未来的治疗师和牙医。正如工作中所指出的,医学领域的法规和标准在不同层次的医疗机构中组织高质量的患者护理方面也发挥着重要作用。此外,提供医疗服务过程数字化领域的各种创新在医疗保健领域,特别是在治疗和牙科领域发挥着主导作用。正是出于这个原因,对最佳做法的研究以及俄罗斯和外国同行的经验,使其能够通过在患者治疗领域应用创新工具和方法来扩大其活动范围。总的来说,提高牙科和治疗领域患者护理质量的前景不仅会实现这一目标,而且会加快这些医疗领域的发展步伐,这将对国内医学的总体发展产生有利影响。
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引用次数: 0
Influence of Earth magnetic field on animal nervous system evolution 地球磁场对动物神经系统进化的影响
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.01.24
Kamila Ahmed, B. jaoui, W. Sahnoun, Noureddine Mechouk, H. Abdelmelek, Z. Bouslama
The aim of the present study was to demonstrate the impacts of earth magnetic field (ErMF) on animal nervous system evolution especially electric and histological properties of nerves. We have applied for the first time, as far as we know, a correlation betwen the influence of ErMF and temperature on supraconductor-like behavior in the siatic nerves of four species. Our question point to answer to the a possible link between magnetic change and climate change and to explain in part the possible implication of both parameters in animal nervous system adaptation and evolution. Our results seem to support the existence of a link between ErMF variation and superconductor-like behavior in nerves. The found link does not mean that the ErMF is fully responsible of the histological, electric properties of nerves and climate changes. The data reveal a decrease in nerve resistivity in chameleon and frog, chick and rabbit; showing a superconductor-like behaviour. Analysis of electrical properties demonstrated a clear grade shift at critical temperature (Tc) from poikilotherm (average of ΔT = 11.50) to homeotherm (average of ΔT = 38.00); indicating adaptive nerves changes during evolution confirmed by the increase of Schwann cells number.
本研究旨在探讨地磁场(ErMF)对动物神经系统进化的影响,特别是对神经的电特性和组织学特性的影响。据我们所知,我们首次应用了电磁场和温度对四种动物坐骨神经类超导体行为影响的相关性。我们的问题指向回答磁场变化和气候变化之间的可能联系,并部分解释这两个参数在动物神经系统适应和进化中的可能含义。我们的结果似乎支持在ErMF变化和神经超导体行为之间存在联系。发现的联系并不意味着ErMF对神经的组织学、电学特性和气候变化负有全部责任。数据显示变色龙、青蛙、小鸡和兔子的神经电阻率下降;表现出类似超导体的行为。电学性质分析表明,在临界温度(Tc)下,从准恒温(平均ΔT = 11.50)到恒温(平均ΔT = 38.00)有明显的等级变化;这表明进化过程中适应性神经发生了变化,雪旺细胞数量的增加证实了这一点。
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引用次数: 0
Principles and Advantages of New Drug Delivery Technologie 新型给药技术的原理与优势
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.02
Hussein Alkufi, Ahmed Salman, S. Taher
Advanced drug delivery systems offer undeniable benefits for drug delivery. In the past three decades, new methods have been proposed to develop a novel carriers for drug delivery. Nowadays, the major goal is to maximize therapeutic benefit while minimizing side effects. Drug delivery technique is clearly shifting from the micro to nanoscale. Nano-drug delivery systems (NDDSs) are the most promising approach utilized to improve the accuracy of drug delivery and the efficacy of drugs.In this narrative review article, we evaluate how delivery challenges associated with commercial marketed products and discuss newer DDS is being carried out to overcome these challenges .Different colloidal carrier systems such as carbon nanotube ,liposome , were being studied and extensively investigated.
先进的给药系统为给药提供了不可否认的好处。在过去的三十年里,人们提出了新的方法来开发一种新的药物递送载体。现在,主要的目标是使治疗效果最大化,同时使副作用最小化。药物输送技术显然正在从微观尺度向纳米尺度转变。纳米给药系统(NDDSs)是提高给药准确性和药物疗效最有前途的方法。在这篇叙述性的综述文章中,我们评估了与商业销售产品相关的递送挑战,并讨论了新的DDS是如何克服这些挑战的。不同的胶体载体系统,如碳纳米管,脂质体,正在被研究和广泛研究。
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引用次数: 0
Effect of In-Office Bleaching Agents on Three Different Esthetic Restorative Materials: An In Vitro Study 室内漂白剂对三种不同美学修复材料的影响:体外研究
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.29
Hisham Mostafa, F. Othman, Hanan Abouelseoud, Dalia M Abouelmagd, A. Naga
Objective: The purpose of this study was to evaluate the effect of two hydrogen peroxide concentrations, commonly used in In-Office bleaching, on the surface roughness and color change of different esthetic restorative materials. Materials and Methods: Sixty disc samples (10 mm in diameter and 2 mm in thickness) of the different restorative materials used were constructed following the manufacturers’ instructions. Samples were classified into three main groups (n=20) according to the type of restorative material: Group1: Microhybrid composite Filtek P90 Silorane, Group 2: IPS emax Press and Group 3: Vitadur Alpha porcelain. Each of the three groups was divided into two subgroups (n=10) (a and b) according to the type of bleaching agent used (Opalesence Xtra Boost 35% hydrogen peroxide (HP) and Zoom 2 25% HP respectively). Samples of subgroups were further divided into two equal divisions (n=5) according to the type of test performed (Roughness testing and Color assessment). Each sample was assessed for surface roughness and color change before bleaching so that each sample served as its own control. Surface roughness was examined using Environmental scanning electronic microscope (ESEM). Color measurements were made with spectrophotometer using CIELAB color scale. One sample from each subgroup was examined to confirm their crystalline phase before and after bleaching using X-Ray Diffraction. Results were statistically analyzed. Results: Significant differences in Ra values were observed between the unbleached and bleached samples, as well as between subgroups treated with Opalesence Xtra Boost and those treated with Zoom 2. The two bleaching agents had statistically significant effect on the color of restorative materials (P<0.05). Moreover, the color change was found to be significantly higher for the restorative materials treated with Opalesence Xtra Boost compared to Zoom 2, regarding their mean ΔE values. Conclusion: Highly concentrated in-office bleaching systems adversely affected the surface roughness and color of Filtek P90 Silorane, IPS e-max Press and Vitadur Alpha porcelain.
目的:评价两种过氧化氢浓度对不同美容修复材料表面粗糙度和颜色变化的影响。材料和方法:根据制造商的说明,制作60个不同修复材料的圆盘样品(直径10 mm,厚度2 mm)。根据修复材料的类型,将样品分为三组(n=20):第一组:微杂化复合材料Filtek P90 Silorane,第二组:IPS emax Press,第三组:Vitadur Alpha瓷。根据使用的漂白剂类型(分别为Opalesence extra Boost 35%过氧化氢(HP)和Zoom 2 25% HP),将三组中的每一组分为两个亚组(n=10) (a和b)。亚组样本根据测试类型(粗糙度测试和颜色评估)进一步分为两等分(n=5)。每个样品在漂白前都要评估表面粗糙度和颜色变化,这样每个样品都可以作为自己的对照。采用环境扫描电镜(ESEM)检测表面粗糙度。用CIELAB色标分光光度计测色。每个亚组的一个样品在漂白前后用x射线衍射检查以确认其结晶相。结果进行统计学分析。结果:在未漂白和漂白的样品之间,以及用Opalesence extra Boost处理的亚组和用Zoom 2处理的亚组之间,Ra值有显著差异。两种漂白剂对修复材料颜色的影响有统计学意义(P<0.05)。此外,与Zoom 2相比,使用Opalesence extra Boost处理的修复材料的颜色变化明显更高,其平均值为ΔE值。结论:高浓度的办公室漂白系统对Filtek P90 Silorane、IPS e-max Press和Vitadur Alpha瓷的表面粗糙度和颜色有不利影响。
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引用次数: 0
Free Radical Scavenging Activity of Clove and Cumin Formulation Mediated Selenium Nanoparticl 丁香和孜然配方介导的硒纳米颗粒自由基清除活性研究
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.14
Asmidha T, R. S, T. Lakshmi, S. G
Background: Selenium nanoparticles (SeNPs) have the potential to be used for various applications.The green SeNPs (selenium nanoparticles) are formed by simple mixing Withania somnifera (W. somnifera) leaves extract and selenious acid (H2SeO3) solution. Nanoparticles have revolutionized for targeted drug delivery by minimizing the toxicity and side effects that commercially available drugs may have on patients. In this study we have chosen the clove and cumin because it protects from cholesterol, inflammatory damage and it has antioxidant property Aim: The aim of the study is to analyze the antioxidant activity of clove and cumin formulation mediated selenium nanoparticles. Materials & Methods: Cumin and Clove were powdered and stored in an air-sealed container. 1g of cumin and clove formulation was mixed with 100 ml of distilled water and boiled for 15 minutes and the formulation was filtered with Whatmann No.1 filter paper. 30mM sodium selenite was prepared in 50 ml of distilled water. 50 ml of sodium selenite solution and 50 ml of clove and cumin formulation was mixed and kept in a rotary shaker for 48 hours. UV spectroscopy reading based on color change was observed. Results: The antioxidant effect of selenium nanoparticles showed a higher percentage of inhibition at 50µg/ml in DPPH Assay and H2O2 Assay. The clove and cumin extract showed an increased percentage of inhibition with increasing concentration. Conclusion: The clove and cumin formulation mediated selenium nanoparticles acts as potent antioxidant agents. It also has the least side effects compared to commercial drugs.
背景:硒纳米颗粒(SeNPs)具有广泛的应用潜力。通过将Withania somnifera (W. somnifera)叶片提取物与亚硒酸(H2SeO3)溶液简单混合形成绿色硒纳米粒子。纳米颗粒通过将市售药物可能对患者产生的毒性和副作用降至最低,彻底改变了靶向药物输送。在本研究中,我们选择丁香和孜然,因为它可以防止胆固醇,炎症损伤,并具有抗氧化性能。目的:本研究的目的是分析丁香和孜然配方介导的硒纳米颗粒的抗氧化活性。材料与方法:将孜然和丁香制成粉末,保存在气密容器中。取1g孜然丁香配方与100ml蒸馏水混合,煮沸15分钟,用Whatmann 1号滤纸过滤。用50 ml蒸馏水配制30mM亚硒酸钠。将亚硒酸钠溶液50 ml与丁香孜然制剂50 ml混合,在旋转摇床中保存48小时。观察了基于颜色变化的紫外光谱读数。结果:纳米硒对DPPH和H2O2的抗氧化作用在50µg/ml时均有较高的抑制率。丁香和孜然提取物的抑制率随浓度的增加而增加。结论:丁香、孜然制剂介导的纳米硒具有较强的抗氧化作用。与商业药物相比,它的副作用也最小。
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引用次数: 0
Economics And Pricing of Certain Segments of The Pharmaceutical Market 医药市场某些细分市场的经济学和定价
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.21
No author No author
Pharmaceutical innovations over the past half century have made it possible to effectively treat and prevent a wide range of diseases. These achievements were so important for modern healthcare that equal access to them is considered one of the basic human rights. This article examines the economics and pricing in certain segments of the pharmaceutical market. The authors analyze various aspects affecting drug prices and price formation mechanisms in various segments of the pharmaceutical industry. The article considers the role of pharmaceutical companies, government regulators and consumers in determining the prices of medicines. The authors investigate the influence of factors such as research and development costs, production costs, patent protection, supply and demand, as well as political and regulatory measures on the formation of prices for pharmaceuticals. It is noted that although the demand for medicines is one of the driving forces of pharmaceutical spending, price increase is the main problem for health system managers, as drug prices increasingly seem unfair. The paper also analyzes various pricing strategies used by pharmaceutical companies, including differentiated pricing, cost pricing and pricing based on the value for a patient. The authors explore the advantages and limitations of each strategy and offer recommendations on the optimal choice of pricing strategy in different segments of the pharmaceutical market. The article ends with the main conclusions and offers recommendations for pharmaceutical companies and government regulators regarding effective pricing in certain segments of the pharmaceutical market, taking into account economic, political and social factors. The study has an important meaning for understanding the complexities and challenges associated with pricing in the pharmaceutical industry and helps to determine optimal pricing strategies for various market segments.
在过去的半个世纪里,医药创新使得有效治疗和预防多种疾病成为可能。这些成就对现代医疗保健非常重要,平等获得这些成就被视为一项基本人权。本文考察了医药市场某些细分市场的经济学和定价。作者分析了影响药品价格的各个方面以及医药行业各个环节的价格形成机制。这篇文章考虑了制药公司、政府监管机构和消费者在确定药品价格方面的作用。这组作者调查了诸如研发成本、生产成本、专利保护、供求关系以及政治和监管措施等因素对药品价格形成的影响。值得注意的是,尽管药品需求是药品支出的驱动力之一,但价格上涨是卫生系统管理人员面临的主要问题,因为药品价格似乎越来越不公平。本文还分析了制药公司使用的各种定价策略,包括差异化定价、成本定价和基于患者价值的定价。作者探讨了每种定价策略的优势和局限性,并对不同细分市场的药品定价策略的最优选择提出了建议。文章以主要结论结束,并为制药公司和政府监管机构提供了关于在药品市场某些细分市场有效定价的建议,考虑到经济、政治和社会因素。该研究对于理解制药行业定价的复杂性和挑战具有重要意义,并有助于确定各个细分市场的最佳定价策略。
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引用次数: 0
Intelligent assistant to predict and control the home appliances in user environment through brain computer interface using hybrid deep learning model 智能助手采用混合深度学习模型,通过脑机接口对用户环境中的家电进行预测和控制
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.02.23
Dr. G. Mohanraj, D. Nithyashri, Dr. V. Siva Brahmaiah, D. Shankar, Srithar S, Mr Azariya
Brain Computer Interface (BCI) is the fast-growing research area that focuses on establishing the symbiotic relation between human brain and artificial intelligence. BCI enable the users to directly communicate with a computer by means of brain activity. Disability of a person due to medical issues such as spinal cord injury or cervical issues makes him/her to depend on caretakers for operating the home appliances. With the advancements in BCI technology, disabled people can control the home appliances through their brain activity without depending on caretaker. The existing models have accessibility challenges for the disabled people in two aspects Viz. accuracy and interaction time. The lack of high prediction accuracy as well as longer interaction time makes the existing models ineffective for the usage. To address the issues, hybridized deep learning model comprising Stacked Denoising Autoencoders and Extreme Machine learning is proposed and examined in this research. The proposed model acquires and preprocess the brain data of user and predicts the user intention with the improved accuracy. The proposed model is compared with different existing models investigated in the literature. The proposed approach achieves the maximum testing accuracy of 91.8% with 70% of training (10,500 Sample) and 30% of test validation (4,500 Sample) on the brain data of single user and takes interaction time of 0.48 seconds. The evaluation results of model validate the effectiveness of the proposed methodology.
脑机接口(BCI)是一个快速发展的研究领域,其重点是建立人类大脑与人工智能之间的共生关系。脑机接口使用户能够通过大脑活动直接与计算机进行交流。由于医疗问题(如脊髓损伤或颈椎问题)造成的残疾,使他/她依靠看护人操作家用电器。随着脑机接口技术的进步,残疾人可以通过大脑活动来控制家用电器,而不需要依靠看护人。现有的模型在准确性和交互时间两个方面对残疾人的可访问性提出了挑战。现有模型预测精度不高,交互时间较长,使其在实际应用中效果不佳。为了解决这些问题,本研究提出并检验了由堆叠去噪自编码器和极限机器学习组成的混合深度学习模型。该模型对用户大脑数据进行预处理,预测用户意图,提高了预测精度。将所提出的模型与文献中已有的不同模型进行了比较。该方法对单个用户的大脑数据进行70%的训练(10500个样本)和30%的测试验证(4500个样本),达到了91.8%的最大测试准确率,交互时间为0.48秒。模型的评价结果验证了所提方法的有效性。
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引用次数: 0
Antimicrobial And Cytotoxic Effect of Selenium Nanoparticles Synthesized Using Clove and Cumin Formulation 丁香和孜然合成纳米硒的抗菌和细胞毒作用
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.17
Mufeetha M, R. S, T. Lakshmi
Aim: The purpose of this study is to use clove and cumin extract to produce the selenium nanoparticles via green approach. Selenium nanoparticles synthesized using clove and cumin formulation nanotechnology explores a lot of interesting approaches in the field of biomedicine. Researchers have recently developed interest in biomolecule-mediated nanoparticle production because of its eco-friendly and non-toxic properties. Clova and cumin have long been used in traditional medicine to treat various illnesses. Materials And Method: Collection of clove and cumin extract then 1 g of clove and cumin, powder was dissolved in distilled water and boiled for 5–10 min at 60–70C. The solutions were then filtered using Whatman No. 1 filter paper. The filtered extract was collected, synthesis of seleniu
目的:以丁香和孜然提取物为原料,采用绿色法制备纳米硒。以丁香和孜然为原料合成硒纳米粒子的纳米技术在生物医学领域探索了许多有趣的方法。近年来,研究人员对生物分子介导的纳米颗粒生产产生了兴趣,因为它具有环保和无毒的特性。在传统医学中,克洛瓦和孜然一直被用来治疗各种疾病。材料与方法:收集丁香和孜然提取物,取丁香和孜然提取物1 g,将粉末溶解于蒸馏水中,60 - 70℃煮沸5-10 min。然后用Whatman 1号滤纸过滤溶液。收集过滤后的提取物,合成硒
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引用次数: 0
Anticariogenic activity of Rose Jasmine formulation mediated silver nanoparticles 玫瑰茉莉配方中纳米银的抗肿瘤活性
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.01.26
S. Bhavesh, A. Arthanari, S. Rajeshkumar
Introduction: Rose (rosa canina) is one of the flowers that are much in demand by the community because besides being an ornamental flower it can also be used as a cosmetic base material. Metallic silver (Ag) is a resilient transition element that has been utilised for a long time in jewellery, coinage, and silverware due to its scarcity (ranking 67th in abundance among the elements) and alluring white metallic brilliance. Aim: To study the anticariogenic activity of Rose Jasmine formulation mediated silver nanoparticles. Materials and methods: Muller hinton agar were utilised to identify the zone of inhibition at different concentrations of the prepared extract mediated with silver nanoparticles. Results: It showed that the prepared extract had an average of zone of inhibition at 100ul of the prepared extract. Conclusion: The prepared extract mediated silver nanoparticles had good anticariogenic activity at 100ul concentration.
简介:玫瑰(rosa canina)是社会上需求量很大的花卉之一,因为除了作为观赏花卉外,它还可以用作化妆品的基础材料。金属银(Ag)是一种弹性过渡元素,由于其稀缺性(在元素丰度中排名第67位)和诱人的白色金属光泽,长期以来一直用于珠宝,铸币和银器中。目的:研究玫瑰茉莉花制剂中纳米银的抗肿瘤活性。材料和方法:利用Muller hinton琼脂鉴定不同浓度的银纳米颗粒介导的提取物的抑制区。结果:制备的提取物在100ul时具有平均的抑制带。结论:制备的提取物介导的银纳米颗粒在100ul浓度下具有良好的抗肿瘤活性。
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引用次数: 0
Prophylactic Measures in the Field of the Prevention of Intestinal Infections in Children and Adults 儿童和成人肠道感染预防领域的预防措施
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.01.02
Elena Tyurkina, Robert Chotchaev, Yana Paromova, Galina Godunova, P. Sergeev, A. Kokareva
The article discusses the features of prophylactic measures in the field of preventing the development of intestinal infections in children and adults. The author notes that taking proper measures on time in this area will reduce the dynamics of the spread of such diseases, as well as the number of cases of intestinal infections among people. The prevention measures which are considered in this work should be implemented in organizations, educational institutions and public places. This will reduce the cost of the consequences of the spread of various intestinal infections and preserve the health of adults and children, since the consequences of intestinal diseases can be significant for a person and cause the development of various systemic diseases of the gastrointestinal tract.
本文讨论了预防儿童和成人肠道感染发展的预防措施的特点。提交人指出,在这一领域及时采取适当措施将减少这类疾病的传播动态,并减少人群中肠道感染病例的数量。这项工作中考虑的预防措施应在组织、教育机构和公共场所实施。这将减少各种肠道感染传播后果的成本,并保护成人和儿童的健康,因为肠道疾病的后果对个人来说可能是重大的,并导致各种胃肠道全身性疾病的发展。
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引用次数: 0
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Journal of Complementary Medicine Research
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