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Investigation of the Causes and Ways of Reducing Injuries in Age-Related Patients with Multimorbidity 高龄多病患者减少损伤的原因及方法探讨
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.02.10
Lada Ratushnaya, Diana Gabelaia, Sofia Petrova, Tatiana Maksimenko, S. Barinov, Alexander Markov
The article investigates the causes and ways to reduce injuries in age-related patients with multimorbidity. The author points out that Multimorbid people are at significant risk of falls. These results require prioritization of falls as a public health problem with the need to integrate falls into existing geriatric healthcare programs. The combination of multimorbidity and proximal fracture leads to an increase in mortality, which strongly indicates the need for more comprehensive approaches to high-risk patients. Accordingly, there is a need for future research on the care of high-risk patients after a fracture and the study of the relationship between multimorbid clusters and other signaling events in the field of healthcare.
本文探讨了老年多病患者损伤的原因及减少损伤的方法。作者指出,患有多种疾病的人摔倒的风险很大。这些结果要求优先考虑跌倒作为一个公共卫生问题,需要将跌倒纳入现有的老年保健计划。多发病和近端骨折的结合导致死亡率增加,这强烈表明需要对高危患者采取更全面的治疗方法。因此,未来有必要对骨折后高危患者的护理进行研究,并研究多病聚集性与医疗保健领域其他信号事件之间的关系。
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引用次数: 0
A Case Series of Dyslipidemia Managed with Kutaki (Picrorhiza Kurroa Royle Ex Benth) 库塔基治疗血脂异常1例(Picrorhiza Kurroa Royle Ex Benth)
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.12
S. Wajpeyi, Vaishali Kuchewar, Ketki Wajpeyi
Background-Raised total cholesterol, high LDL-C, low HDL-C, and elevated triglycerides are all symptoms of dyslipidemia. It is included in metabolic disorders. It is a major component in causation of atherosclerosis, coronary artery disease and cerebrovascular disease. There is a 1-2 percent rise in the incidence of Coronary Heart Disease for every 1% increase in cholesterol level. As per Ayurveda, it can be considered as a Medadhatu Dushti that is “Medoroga”. Acharya Charaka described drugs having deepana, pachana, medohar, lekhana and strotoshodhaka properties for management of Medoroga. Kutaki (Picrorhiza kurroa Royle ex. Benth) can be used in such conditions due to its lekhana and medohar properties.Various animal research studies conducted on Kutaki proved its antihyperlipidemic and hepatoprotective property. Hence in this case series three patients of dyslipidemia were treated with single dravya Kutaki in tablet form. Case Report-All the three female patients, aged between 40 to 50 years, were treated with Kutaki tablet (500mg) two times a day in the morning and evening (8am-8pm) empty stomach with water for 60 days. After completion of treatment, assessment was done by comparing Serum lipid profile value as with baseline after completion of treatment. Observations and Result -All the three patients showed improvement in lipid values. There was no change in weight or BMI was noted. Conclusion-Hence, it can be concluded that Kutaki is safe and effective in dyslipidemia for normalization of lipid in the blood due to its lekhana, Kapha Medohara (alleviation of vitiated Kapha and Meda) properties.
背景:总胆固醇升高、低LDL-C、低HDL-C和甘油三酯升高都是血脂异常的症状。它包括在代谢紊乱中。它是导致动脉粥样硬化、冠状动脉疾病和脑血管疾病的主要成分。胆固醇水平每增加1%,冠心病的发病率就会增加1- 2%。根据阿育吠陀,它可以被认为是Medadhatu Dushti,即“Medoroga”。Acharya Charaka描述了具有deepana, pachana, medohar, lekhana和strotoshodhaka属性的药物用于治疗梅多罗加。库塔木(Picrorhiza kurroa Royle ex. Benth)由于其lekhana和medohar特性可以在这种条件下使用。各种动物实验证明了它的抗高脂血症和保护肝脏的特性。因此,在本病例中,三例血脂异常患者均以片剂形式服用单药。病例报告-所有3例女性患者,年龄在40至50岁之间,每天两次,早晚(上午8点至晚上8点)空腹加水治疗Kutaki片(500mg),持续60天。治疗结束后,通过比较治疗结束后的血脂值与基线值进行评估。观察与结果:3例患者血脂值均有改善。体重和身体质量指数没有变化。结论:库塔木因其lekhana、Kapha Medohara(减轻Kapha和Meda受损)的特性,对血脂异常的治疗是安全有效的。
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引用次数: 0
Evaluation of Wound Healing Potential of ethanolic extract of Tridax Procumbens L. in clinical models 原藜醇提物在临床模型中的创面愈合潜力评价
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.02.04
A. Padmapriya, R. Priyadharshini, Palati Sindhuja
Wound healing is a complicated process in which the skin or the afflicted organ heals itself after an injury. In numerous animal models, scientific validation for the use of most of these botanical parts and species in the management and treatment of prenatal and postnatal complications has been reported. As a result of its bioactivity, biocompatibility, osteoconductivity, structural and chemical similarity to bone and teeth, host tissue bonding ability, and absence of inflammatory characteristic, it has the capacity to regenerate tissue. Our study aimed to identify the wound healing property of Tridax procumbens in Clinical models. In this study we have identified the various phytochemical activities such as cytotoxic effect, anti inflammatory, anti microbial, free radical scavenging and wound healing activity of tridax procumbens. It was found that Tridax procumbens accelerated the healing process by enhancing the epithelial regeneration of wounds. The potent activity of the herbal formulation can be attributed to the phyto-constituents present in the formulation enhance the wound healing effect. Additional research is necessary to understand both the target-based mechanism of action and other pharmacological effects
伤口愈合是一个复杂的过程,在这个过程中,皮肤或受伤的器官在受伤后自行愈合。在许多动物模型中,已经报道了在产前和产后并发症的管理和治疗中使用大多数这些植物部分和物种的科学验证。由于其生物活性、生物相容性、骨导电性、与骨和牙齿的结构和化学相似性、宿主组织结合能力以及无炎症特征,它具有再生组织的能力。我们的研究目的是在临床模型中鉴定原藜草的伤口愈合特性。在本研究中,我们鉴定了三甘树的多种植物化学活性,如细胞毒作用、抗炎、抗微生物、自由基清除和伤口愈合活性。结果表明,原藜通过促进创面上皮细胞的再生来促进创面愈合。草药配方的有效活性可归因于配方中存在的植物成分增强了伤口愈合效果。需要进一步的研究来了解基于靶标的作用机制和其他药理作用
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引用次数: 0
Comparison Of Histomorphology, Angiogenesis and Proliferation in Kappa and Lambda Restricted Plasma Cell Myelomas with Its Effect on Prognosis Kappa和Lambda限制性浆细胞骨髓瘤组织形态学、血管生成和增殖的比较及其对预后的影响
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.13
S. Priyadarshini, D. Basu, R. Kar, T. Dutta
Aims Of the Study: To study the type of light chain restriction and correlate it with the morphological parameters, proliferation index, angiogenesis and clinical parameters. Materials And Methods: The study includes 46 cases of myeloma diagnosed over the period of five years. The histomorphological features like plasma cell morphology, percentage of plasma cells and pattern of infiltration were studied. Immunohistochemistry for kappa and lambda light chains was done. Angiogenesis was assessed by calculating the microvessel density (MVD) using anti CD34 immunohistochemistry. Proliferation was assessed immunohistochemically using Ki67 by comparing with anti CD38 which was used to highlight the plasma cells. Results: The cases with kappa light chain restriction had significantly less of poorly differentiated morphology (7.4% vs 36.8%; p=0.02) and diffuse pattern of infiltration (22% vs 63%; p=0.01) compared to lambda. The kappa group also had lower MVD (9.9 vs 16.5; p=0.02) and proliferation index (4.7 vs 94; p=0.04) compared to the lambda. Conclusion: Therefore, the type of light chain restriction is also a prognostic factor in plasma cell myeloma.
研究目的:研究轻链限制类型及其与形态学参数、增殖指数、血管生成及临床参数的关系。材料和方法:该研究包括在五年内诊断的46例骨髓瘤病例。研究了浆细胞形态、浆细胞百分比、浸润方式等组织形态学特征。对kappa和lambda轻链进行免疫组化处理。利用抗CD34免疫组化技术计算微血管密度(MVD)来评估血管生成。用免疫组织化学方法Ki67检测浆细胞的增殖情况,并与抗CD38进行比较。结果:kappa轻链限制组低分化形态发生率显著降低(7.4% vs 36.8%;P =0.02)和弥漫性浸润模式(22% vs 63%;P =0.01)。kappa组的MVD也较低(9.9 vs 16.5;P =0.02)和增殖指数(4.7 vs 94;P =0.04)。结论:轻链限制类型也是影响浆细胞骨髓瘤预后的因素之一。
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引用次数: 0
Determining Nursing Students’ Dominant Learning Styles and Evaluating the Affecting Factors Using Decision Tree Method 运用决策树法确定护生优势学习风格并评价影响因素
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.02.08
Didem mehmet, lknur rkbir, Bahar nba, I. l
Aim and Background: Identifying the learning styles is important to ensure full and effective learning in nursing students studying in a field that requires clinical practice and experience. For this aim, determined the dominant learning styles of nursing students and to evaluate the affecting factors using the decision tree method. Methods: The study was conducted with 421 students studying nursing at a university in Turkey. “CART”, “CHAID” and “QUEST” decision tree algorithms were used to evaluate the factors affecting learning styles. Results: Of the students, 48% had visual, 36% tactile, 9% kinesthetic, and 7% auditory learning styles. In the decision tree model, living place and university entrance scores were found to have statistically significant effects on learning styles (p<0.05). Conclusion: This study determined that nursing students predominantly had the visual learning style and that the living place was the variable with the most pronounced effect on learning style.
目的与背景:在需要临床实践和经验的护理专业学习中,识别学习风格对于确保充分有效的学习至关重要。为此目的,确定护生的主要学习风格,并采用决策树法评价其影响因素。方法:对土耳其一所大学护理专业的421名学生进行研究。采用“CART”、“CHAID”和“QUEST”决策树算法评价影响学习风格的因素。结果:48%的学生有视觉学习风格,36%的学生有触觉学习风格,9%的学生有动觉学习风格,7%的学生有听觉学习风格。在决策树模型中,居住地点和大学入学分数对学习风格的影响有统计学意义(p<0.05)。结论:本研究确定护理生以视觉学习风格为主,居住环境是影响学习风格最显著的变量。
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引用次数: 0
Role of methylphenidate in cancer-related fatigue: A Systemic Review 哌醋甲酯在癌症相关疲劳中的作用:一项系统综述
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.35
Abdulrahman Alardan, H. Alkhudairi, Ghanim Almotiri, Saad Shamsy
Introduction: Cancer-related fatigue (CRF) is a substantial medical issue that affects patients at all phases of their therapy and escalates with advanced cancer. To gather indications for the use of methylphenidate is objective of the study for the treatment of CRF, as well as to analyse the efficiency and safety of methylphenidate for the treatment of CRF so that we can tailor methylphenidate treatment to response patient only. Methods: To conduct the review of RCTs Systematic Reviews (PRISMA) statement was ideally chosen for Reporting Items. From inception through the first week of October 2021, A systematic search of the electronic databases PubMed, Embase, PSYCHInfo, and the Cochrane Library was done without any language restrictions. This helped to find all RCTs about the use of methylphenidate in patients with CRF. Search terms used were: methylphenidate, dexmethylphenidate, Ritalin, cancer, tumor, carcinoma, neoplasm, fatigue, asthenia, tiredness, CRF, and RCT. We also looked over a few journals' references to find more theoretically related papers. Results: A total of 267 citations were screened; among them, after a preliminary review 231 were excluded. 36 full-text articles assessed for eligibility; among them, 10 articles were met the inclusion criteria where all the selected articles were of good quality. Among 10 studies, 5 were identified in mixed tumor, 2 in prostate cancer, 1 in GI cancer, 1 in advanced cancer and 1 in Gynaecologic cancer. The characteristics of the studies changed broadly in terms of the treatment term and the population studied. Conclusion: To summarize up this study, cancer-related weakness could be critical clinical issue for cancer patients. Our findings suggest that methylphenidate may be useful in the treatment of CRF, but the evidence is inconclusive and has to be confirmed in a bigger study. All of the investigations, however, had tiny sample sizes. This counsel must be respected as provisional and temporary within the absence of considerable information from a single, expansive, well conducted randomized controlled trial. To support and propose new research topics and interventions, more study into biological factors affecting weariness is required.
癌症相关疲劳(CRF)是一个重要的医学问题,影响患者治疗的所有阶段,并随着癌症晚期而升级。收集哌甲酯治疗慢性心力衰竭的适应症是本研究的目的,同时分析哌甲酯治疗慢性心力衰竭的有效性和安全性,以便我们根据患者的反应量身定制哌甲酯治疗。方法:对随机对照试验进行回顾性评价,报告项目选择系统评价(PRISMA)语句。从开始到2021年10月的第一周,在没有任何语言限制的情况下,对PubMed, Embase, PSYCHInfo和Cochrane图书馆的电子数据库进行了系统搜索。这有助于找到所有关于在慢性肾功能衰竭患者中使用哌甲酯的随机对照试验。搜索词包括:哌甲酯,哌甲酯右旋,利他林,癌症,肿瘤,癌,肿瘤,疲劳,虚弱,疲劳,CRF和RCT。我们还查阅了一些期刊的参考文献,以找到更多与理论相关的论文。结果:共筛选到267篇文献;其中,经初步审查,231项被排除在外。36篇全文文章进行资格评估;其中10篇文章符合纳入标准,入选文章质量均为良好。10项研究中,混合肿瘤5项,前列腺癌2项,胃肠道癌1项,晚期癌1项,妇科癌1项。这些研究的特征在治疗期限和研究人群方面变化很大。结论:总结本研究,癌症相关虚弱可能是癌症患者的关键临床问题。我们的研究结果表明,哌醋甲酯可能对慢性肾功能衰竭的治疗有用,但证据不确定,必须在更大的研究中得到证实。然而,所有调查的样本量都很小。这一建议必须被视为是临时的,在缺乏单一的、广泛的、进行良好的随机对照试验的大量信息的情况下是临时的。为了支持和提出新的研究课题和干预措施,需要对影响疲劳的生物学因素进行更多的研究。
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引用次数: 0
Exploring the Potential of Wild Salvia macilenta Boiss. of Oman as Nutraceuticals 探索野生鼠尾草的潜力。阿曼的营养保健品
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.02.07
S. Nadaf, Jamaleldin Sabahi, A. Lawati, Almandhar Mamari, F. Kindi, Abdulaziz Mawal, Houda Ruqaishi, Ahmed Ghafri, A. Farsi, N. Saady
Background: Several plant extracts are now prescribed as nutraceuticals for human ailments in developed countries like China, France, Germany, the UK, USA including Oman. The objective of this study was to investigate on morphological characteristics, chlorophyll content of leaves, leaf chlorophyll, essential oil, and its chemical compounds to examine the possibility of isolating its incipient chemical compounds commercially in wild Salvia macilenta Boiss. Methods: Leaf samples of ten randomly selected Salvia plants were collected from two diversified wadi habitats. Edaphic features of the sites were recorded and their chemical contents, determined. Morphological characters were measured and chlorophyll contents, recorded. The essential oil (EO) was extracted and analyzed for chemical compounds. The data were statistically analyzed. Results: Al-Khoud plants had higher expressivity in all the morphological characters and chlorophyll contents than those of Halban. The EO yields of Salvia macilenta were 0.06 % (v/w) and 0.088 % (v/w) for the plant samples of Al-Khoud and Halban, respectively. The values of commonly occurring chemical contents of plants of two sites were found statistically similar (p<0.05). The top ten chemical compounds of plants contributed over 75% of the total and were common with seven chemical compounds. Of the ten top chemical compounds, alpha-Pinene, beta- Eudesmol, and Nerolidol contributed the highest in the same range from 61.13% (Al-Khoud) to 62.95% (Halban). These three compounds have the potential for use in both the pharmaceutical and perfumery industries. Conclusion: Wild Salvia plants can be exploited with Good Agriculture Practices for their medicinal and aromatic application.
背景:在中国、法国、德国、英国、美国(包括阿曼)等发达国家,几种植物提取物现在被作为人类疾病的营养保健品处方。本研究旨在研究野生鼠尾草的形态特征、叶片叶绿素含量、叶片叶绿素含量、挥发油及其化学成分,探讨其早期化学成分商业化分离的可能性。方法:随机选取10株鼠尾草属植物,采集不同生境的鼠尾草叶样。记录了这些遗址的地理特征,并测定了它们的化学成分。测定其形态特征,记录叶绿素含量。提取精油并分析其化学成分。对数据进行统计学分析。结果:Al-Khoud植株在所有形态特征和叶绿素含量上都比Halban植株具有更高的表达能力。在Al-Khoud和Halban植物样品中,鼠尾草的EO产率分别为0.06% (v/w)和0.088% (v/w)。两地植物常见化学物质含量差异有统计学意义(p<0.05)。植物前十位化合物占总化合物的75%以上,其中有7种化合物为常见化合物。在前10位的化合物中,α -蒎烯、β -桉叶酚和橙花醇的贡献率最高,在相同的范围内,从61.13% (Al-Khoud)到62.95% (Halban)。这三种化合物在制药和香水工业中都有潜在的用途。结论:野生鼠尾草具有良好的药用和芳香性,可根据良好农业规范进行开发利用。
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引用次数: 0
Trends in Euphorbia hirta Research: A 30-year Bibliometric Appraisal of the Present Realities 大戟研究的趋势:对当前现实的30年文献计量学评价
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.01.16
I. Elisha, J. Gotep, M. Makoshi, J. Usman, Blessing Shok, K. Oyebade, Z. Muhammad, Itodo Akogwu, K. Tondo, Hong Joseph, Edirin Akpojosevbe, B. Yakubu, Maryam Division, N. Vom, Plateau Stat
Euphorbia hirta L.. is a common herb with global spread. Different parts of E. hirta are used in traditional medicine for the treatment of a variety of human and animal conditions, such as skin diseases, inflammation, digestive and respiratory disorders. This bibliometric study aimed to provide a panoramic view of the publication landscape in the last thirty years of Euphorbia hirta research. VOSviewer was used to analyze 603 documents retrieved from Scopus database during the period, 1992 to 2021. Dominant research themes in the last thirty years were centred on the application of crude extracts or isolated compounds from E. hirta against diabetes, oxidative stress, inflammation, tuberculosis, snake bite, gastro-intestinal disorders, respiratory infections, skin pathologies, bacterial, fungal and viral infections. Current paradigm shift in E. hirta research are targeted at improving the efficacy of phytomolecules against resistant bacterial pathogens and cancer cells via green synthesis of nanoparticles and the application of in silico technologies in predicting the activities of nano-phytomolecules against SARS-CoV-2 and the dengue virus. This study recommends further research in the determination of the bioavailability of molecules in in vivo models. Researchers should carry out more preclinical investigations with the aim of establishing the pharmacokinetic and pharmacodynamic properties of phytocompounds instead of relying solely on in silico predictions.
大戟hirta L..是一种常见的草本植物,遍布全球。hirta的不同部分在传统医学中用于治疗各种人类和动物疾病,如皮肤病、炎症、消化和呼吸系统疾病。本文献计量学研究旨在提供近三十年大戟研究的出版景观全景视图。使用VOSviewer对1992 ~ 2021年Scopus数据库检索的603篇文献进行分析。在过去的三十年中,主要的研究主题集中在应用hirta的粗提取物或分离化合物来治疗糖尿病、氧化应激、炎症、肺结核、蛇咬伤、胃肠道疾病、呼吸道感染、皮肤病变、细菌、真菌和病毒感染。目前,hirta研究的范式转变旨在通过纳米颗粒的绿色合成和应用硅技术预测纳米植物分子对SARS-CoV-2和登革热病毒的活性,提高植物分子对耐药细菌病原体和癌细胞的功效。本研究建议进一步研究确定分子在体内模型中的生物利用度。研究人员应该开展更多的临床前研究,目的是建立植物化合物的药代动力学和药效学特性,而不是仅仅依靠计算机预测。
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引用次数: 1
Review Of Physiological Responses to Eight-Week Basketball Trainings 八周篮球训练的生理反应回顾
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.03.25
Abdullah Demirli, Emre Yamaner, Eda elik, A. Moghanlou
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引用次数: 0
Application of Convolutional Neural Network for Cancer Disease Diagnosis – A Deep Learning based Approach 卷积神经网络在癌症诊断中的应用——一种基于深度学习的方法
IF 0.6 Pub Date : 2023-01-01 DOI: 10.5455/jcmr.2023.14.01.14
S. Sivanantham, D. M, A. Velmurugan, Dr. T. Deepa, Akshaya V
Human are vulnerable to the terrible disease named cancer, which is a major factor in the high mortality rate. There are currently lesser DLTs (Deep learning techniques) or MLTs (machine learning techniques) for identifying cancer, despite advances in cancer treatment approaches. The proposed work performs a comparative study which compares the some significant DLTs like RFs (Random Forests), LSTMs (Long Short Term Memories), CNNs (Convolutional Neural Networks) and BPNNs (Back Propagation Neural Networks). These techniques are used here in this work for classification problem. The techniques are made to classify the medical records into benignand cancerous. Three pathological datasets are used to evaluate the above said techniques. CNNs provide the best performance of 0.97 accuracy and it is even good at its values of precisions, recalls and F1 scores.
人类很容易患上一种叫做癌症的可怕疾病,这是造成高死亡率的一个主要因素。尽管癌症治疗方法取得了进展,但目前用于识别癌症的dlt(深度学习技术)或mlt(机器学习技术)较少。提出的工作进行了一项比较研究,比较了一些重要的dlt,如rf(随机森林),LSTMs(长短期记忆),cnn(卷积神经网络)和bpnn(反向传播神经网络)。这些技术在本工作中用于分类问题。该技术用于将医疗记录分为良性和恶性。三个病理数据集用于评估上述技术。cnn提供了0.97准确率的最佳性能,甚至在精度,召回和F1分数方面也很好。
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引用次数: 0
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Journal of Complementary Medicine Research
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