Pub Date : 2023-01-01DOI: 10.5455/jcmr.2023.14.02.10
Lada Ratushnaya, Diana Gabelaia, Sofia Petrova, Tatiana Maksimenko, S. Barinov, Alexander Markov
The article investigates the causes and ways to reduce injuries in age-related patients with multimorbidity. The author points out that Multimorbid people are at significant risk of falls. These results require prioritization of falls as a public health problem with the need to integrate falls into existing geriatric healthcare programs. The combination of multimorbidity and proximal fracture leads to an increase in mortality, which strongly indicates the need for more comprehensive approaches to high-risk patients. Accordingly, there is a need for future research on the care of high-risk patients after a fracture and the study of the relationship between multimorbid clusters and other signaling events in the field of healthcare.
{"title":"Investigation of the Causes and Ways of Reducing Injuries in Age-Related Patients with Multimorbidity","authors":"Lada Ratushnaya, Diana Gabelaia, Sofia Petrova, Tatiana Maksimenko, S. Barinov, Alexander Markov","doi":"10.5455/jcmr.2023.14.02.10","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.02.10","url":null,"abstract":"The article investigates the causes and ways to reduce injuries in age-related patients with multimorbidity. The author points out that Multimorbid people are at significant risk of falls. These results require prioritization of falls as a public health problem with the need to integrate falls into existing geriatric healthcare programs. The combination of multimorbidity and proximal fracture leads to an increase in mortality, which strongly indicates the need for more comprehensive approaches to high-risk patients. Accordingly, there is a need for future research on the care of high-risk patients after a fracture and the study of the relationship between multimorbid clusters and other signaling events in the field of healthcare.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"12 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87910846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/jcmr.2023.14.03.12
S. Wajpeyi, Vaishali Kuchewar, Ketki Wajpeyi
Background-Raised total cholesterol, high LDL-C, low HDL-C, and elevated triglycerides are all symptoms of dyslipidemia. It is included in metabolic disorders. It is a major component in causation of atherosclerosis, coronary artery disease and cerebrovascular disease. There is a 1-2 percent rise in the incidence of Coronary Heart Disease for every 1% increase in cholesterol level. As per Ayurveda, it can be considered as a Medadhatu Dushti that is “Medoroga”. Acharya Charaka described drugs having deepana, pachana, medohar, lekhana and strotoshodhaka properties for management of Medoroga. Kutaki (Picrorhiza kurroa Royle ex. Benth) can be used in such conditions due to its lekhana and medohar properties.Various animal research studies conducted on Kutaki proved its antihyperlipidemic and hepatoprotective property. Hence in this case series three patients of dyslipidemia were treated with single dravya Kutaki in tablet form. Case Report-All the three female patients, aged between 40 to 50 years, were treated with Kutaki tablet (500mg) two times a day in the morning and evening (8am-8pm) empty stomach with water for 60 days. After completion of treatment, assessment was done by comparing Serum lipid profile value as with baseline after completion of treatment. Observations and Result -All the three patients showed improvement in lipid values. There was no change in weight or BMI was noted. Conclusion-Hence, it can be concluded that Kutaki is safe and effective in dyslipidemia for normalization of lipid in the blood due to its lekhana, Kapha Medohara (alleviation of vitiated Kapha and Meda) properties.
{"title":"A Case Series of Dyslipidemia Managed with Kutaki (Picrorhiza Kurroa Royle Ex Benth)","authors":"S. Wajpeyi, Vaishali Kuchewar, Ketki Wajpeyi","doi":"10.5455/jcmr.2023.14.03.12","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.12","url":null,"abstract":"Background-Raised total cholesterol, high LDL-C, low HDL-C, and elevated triglycerides are all symptoms of dyslipidemia. It is included in metabolic disorders. It is a major component in causation of atherosclerosis, coronary artery disease and cerebrovascular disease. There is a 1-2 percent rise in the incidence of Coronary Heart Disease for every 1% increase in cholesterol level. As per Ayurveda, it can be considered as a Medadhatu Dushti that is “Medoroga”. Acharya Charaka described drugs having deepana, pachana, medohar, lekhana and strotoshodhaka properties for management of Medoroga. Kutaki (Picrorhiza kurroa Royle ex. Benth) can be used in such conditions due to its lekhana and medohar properties.Various animal research studies conducted on Kutaki proved its antihyperlipidemic and hepatoprotective property. Hence in this case series three patients of dyslipidemia were treated with single dravya Kutaki in tablet form. Case Report-All the three female patients, aged between 40 to 50 years, were treated with Kutaki tablet (500mg) two times a day in the morning and evening (8am-8pm) empty stomach with water for 60 days. After completion of treatment, assessment was done by comparing Serum lipid profile value as with baseline after completion of treatment. Observations and Result -All the three patients showed improvement in lipid values. There was no change in weight or BMI was noted. Conclusion-Hence, it can be concluded that Kutaki is safe and effective in dyslipidemia for normalization of lipid in the blood due to its lekhana, Kapha Medohara (alleviation of vitiated Kapha and Meda) properties.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"138 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86276103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/jcmr.2023.14.02.04
A. Padmapriya, R. Priyadharshini, Palati Sindhuja
Wound healing is a complicated process in which the skin or the afflicted organ heals itself after an injury. In numerous animal models, scientific validation for the use of most of these botanical parts and species in the management and treatment of prenatal and postnatal complications has been reported. As a result of its bioactivity, biocompatibility, osteoconductivity, structural and chemical similarity to bone and teeth, host tissue bonding ability, and absence of inflammatory characteristic, it has the capacity to regenerate tissue. Our study aimed to identify the wound healing property of Tridax procumbens in Clinical models. In this study we have identified the various phytochemical activities such as cytotoxic effect, anti inflammatory, anti microbial, free radical scavenging and wound healing activity of tridax procumbens. It was found that Tridax procumbens accelerated the healing process by enhancing the epithelial regeneration of wounds. The potent activity of the herbal formulation can be attributed to the phyto-constituents present in the formulation enhance the wound healing effect. Additional research is necessary to understand both the target-based mechanism of action and other pharmacological effects
{"title":"Evaluation of Wound Healing Potential of ethanolic extract of Tridax Procumbens L. in clinical models","authors":"A. Padmapriya, R. Priyadharshini, Palati Sindhuja","doi":"10.5455/jcmr.2023.14.02.04","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.02.04","url":null,"abstract":"Wound healing is a complicated process in which the skin or the afflicted organ heals itself after an injury. In numerous animal models, scientific validation for the use of most of these botanical parts and species in the management and treatment of prenatal and postnatal complications has been reported. As a result of its bioactivity, biocompatibility, osteoconductivity, structural and chemical similarity to bone and teeth, host tissue bonding ability, and absence of inflammatory characteristic, it has the capacity to regenerate tissue. Our study aimed to identify the wound healing property of Tridax procumbens in Clinical models. In this study we have identified the various phytochemical activities such as cytotoxic effect, anti inflammatory, anti microbial, free radical scavenging and wound healing activity of tridax procumbens. It was found that Tridax procumbens accelerated the healing process by enhancing the epithelial regeneration of wounds. The potent activity of the herbal formulation can be attributed to the phyto-constituents present in the formulation enhance the wound healing effect. Additional research is necessary to understand both the target-based mechanism of action and other pharmacological effects","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"67 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90595182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/jcmr.2023.14.03.13
S. Priyadarshini, D. Basu, R. Kar, T. Dutta
Aims Of the Study: To study the type of light chain restriction and correlate it with the morphological parameters, proliferation index, angiogenesis and clinical parameters. Materials And Methods: The study includes 46 cases of myeloma diagnosed over the period of five years. The histomorphological features like plasma cell morphology, percentage of plasma cells and pattern of infiltration were studied. Immunohistochemistry for kappa and lambda light chains was done. Angiogenesis was assessed by calculating the microvessel density (MVD) using anti CD34 immunohistochemistry. Proliferation was assessed immunohistochemically using Ki67 by comparing with anti CD38 which was used to highlight the plasma cells. Results: The cases with kappa light chain restriction had significantly less of poorly differentiated morphology (7.4% vs 36.8%; p=0.02) and diffuse pattern of infiltration (22% vs 63%; p=0.01) compared to lambda. The kappa group also had lower MVD (9.9 vs 16.5; p=0.02) and proliferation index (4.7 vs 94; p=0.04) compared to the lambda. Conclusion: Therefore, the type of light chain restriction is also a prognostic factor in plasma cell myeloma.
研究目的:研究轻链限制类型及其与形态学参数、增殖指数、血管生成及临床参数的关系。材料和方法:该研究包括在五年内诊断的46例骨髓瘤病例。研究了浆细胞形态、浆细胞百分比、浸润方式等组织形态学特征。对kappa和lambda轻链进行免疫组化处理。利用抗CD34免疫组化技术计算微血管密度(MVD)来评估血管生成。用免疫组织化学方法Ki67检测浆细胞的增殖情况,并与抗CD38进行比较。结果:kappa轻链限制组低分化形态发生率显著降低(7.4% vs 36.8%;P =0.02)和弥漫性浸润模式(22% vs 63%;P =0.01)。kappa组的MVD也较低(9.9 vs 16.5;P =0.02)和增殖指数(4.7 vs 94;P =0.04)。结论:轻链限制类型也是影响浆细胞骨髓瘤预后的因素之一。
{"title":"Comparison Of Histomorphology, Angiogenesis and Proliferation in Kappa and Lambda Restricted Plasma Cell Myelomas with Its \u0000Effect on Prognosis","authors":"S. Priyadarshini, D. Basu, R. Kar, T. Dutta","doi":"10.5455/jcmr.2023.14.03.13","DOIUrl":"https://doi.org/10.5455/jcmr.2023.14.03.13","url":null,"abstract":"Aims Of the Study: To study the type of light chain restriction and correlate it with the morphological parameters, proliferation index, angiogenesis and clinical parameters. Materials And Methods: The study includes 46 cases of myeloma diagnosed over the period of five years. The histomorphological features like plasma cell morphology, percentage of plasma cells and pattern of infiltration were studied. Immunohistochemistry for kappa and lambda light chains was done. Angiogenesis was assessed by calculating the microvessel density (MVD) using anti CD34 immunohistochemistry. Proliferation was assessed immunohistochemically using Ki67 by comparing with anti CD38 which was used to highlight the plasma cells. Results: The cases with kappa light chain restriction had significantly less of poorly differentiated morphology (7.4% vs 36.8%; p=0.02) and diffuse pattern of infiltration (22% vs 63%; p=0.01) compared to lambda. The kappa group also had lower MVD (9.9 vs 16.5; p=0.02) and proliferation index (4.7 vs 94; p=0.04) compared to the lambda. Conclusion: Therefore, the type of light chain restriction is also a prognostic factor in plasma cell myeloma.","PeriodicalId":41505,"journal":{"name":"Journal of Complementary Medicine Research","volume":"148 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79205333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}