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2008 IEEE Biomedical Circuits and Systems Conference最新文献

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A low power CMOS image sensor design for wireless endoscopy capsule 一种用于无线内镜胶囊的低功耗CMOS图像传感器设计
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696958
Milin Zhang, A. Bermak, Xiaowen Li, Zhihua Wang
This paper proposes a low power full-custom CMOS digital pixel sensor array designed for a wireless endoscopy capsule. The proposed architecture greatly reduces the on-chip memory requirement by sharing pixel-level memory in the sensor array with the digital image processor. The pixel-level memories in the proposed full-custom image sensor are used not only to store the raw image pixel values in the image capture phase, but also is also used as buffers for the digital image processor during the image compression and transmission phase. Low power design is carried out both at the algorithmic and circuit levels, which reduces almost 50% switching activities on data bus, about 80% of power consumption in the main pixel circuit during image capture phase and 15% during image process phase while transmitting data at a rate of 2-frame/s.
提出了一种用于无线内窥镜胶囊的低功耗全定制CMOS数字像素传感器阵列。该架构通过与数字图像处理器共享传感器阵列中的像素级内存,大大降低了片上内存需求。所提出的全定制图像传感器中的像素级存储器不仅用于存储图像捕获阶段的原始图像像素值,而且还用作数字图像处理器在图像压缩和传输阶段的缓冲区。在算法和电路层面都进行了低功耗设计,在以2帧/秒的速率传输数据的情况下,数据总线上的切换活动减少了近50%,图像捕获阶段主像素电路的功耗减少了约80%,图像处理阶段的功耗减少了15%。
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引用次数: 28
A reconfigurable, analog system for efficient stochastic biological computation 一个可重构的模拟系统,用于高效的随机生物计算
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696932
B. Marr, S. Brink, P. Hasler, D.V. Anderson
Motivated by the many stochastic processes found in biology that allow for ultra-efficient computing, this paper explores circuit implementations for stochastic computation in hardware. Several novel contributions are presented in this paper, namely a dynamically controllable system of random number generators that produces Bernoulli random variables, exponentially distributed random variables, and allows for random variables of an arbitrary distribution to be generated. This system is implemented on a reconfigurable analog chipset allowing for the first time ever a hardware stochastic process with a user input to control the probability distribution. The utility of this system is demonstrated by implementing the well-known Gillespie algorithm for simulating an arbitrary biological system trajectory of sufficiently small molecules where over a 127times performance improvement over current software approaches is shown.
受生物学中发现的许多允许超高效计算的随机过程的激励,本文探讨了硬件中随机计算的电路实现。本文提出了几个新颖的贡献,即一个动态可控的随机数发生器系统,它产生伯努利随机变量,指数分布的随机变量,并允许产生任意分布的随机变量。该系统是在一个可重构的模拟芯片组上实现的,允许有史以来第一次使用用户输入来控制概率分布的硬件随机过程。该系统的实用性通过实现著名的Gillespie算法来证明,该算法用于模拟足够小分子的任意生物系统轨迹,其中显示了比当前软件方法提高127倍以上的性能。
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引用次数: 4
An efficient synchronization scheme for digital UWB communication systems for biomedical applications 一种用于生物医学应用的数字超宽带通信系统的有效同步方案
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696862
M.C. Munshi, Jinhua Jiang, Yan Xin, T. Lande, Y. Lian
Wireless biomedical applications require low power operations for long, uninterrupted durations of use. In order to harness the low power characteristics of Ultra Wideband (UWB) systems, issues involving the synchronization of extremely short pulses have to be resolved as they surface as major bottlenecks of the design of such systems. The situation is particularly adverse in short range communication systems operating in dense indoor environments as employed in the biomedical field. In this paper, we present a simple power saving synchronization scheme extended upon a previously implemented spatial rake receiver structure. This scheme, which uses neither high speed ADCs nor conventional analog correlators, allows for significant reduction in receiver power consumption while achieving quick acquisition in the preamble stage under moderate signal to noise ratio (SNR) conditions, by exploiting favorable cross correlation properties of known Barker sequences. This is illustrated by appropriately adjusting the threshold value of the discrete correlation between received data and chosen sequences.
无线生物医学应用需要低功耗操作,长时间不间断使用。为了利用超宽带(UWB)系统的低功率特性,必须解决涉及极短脉冲同步的问题,因为它们是此类系统设计的主要瓶颈。在生物医学领域使用的在密集室内环境中运行的短程通信系统中,这种情况尤其不利。在本文中,我们提出了一种简单的节能同步方案,扩展了先前实现的空间rake接收器结构。该方案既不使用高速adc,也不使用传统的模拟相关器,通过利用已知巴克序列的良好互相关特性,在中等信噪比(SNR)条件下实现前置级的快速采集,同时显著降低了接收机功耗。这是通过适当调整接收数据和所选序列之间的离散相关性的阈值来说明的。
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引用次数: 3
Wireless integrated circuit for 100-channel neural stimulation 用于100通道神经刺激的无线集成电路
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696891
B. Thurgood, N. M. Ledbetter, David J. Warren, Gregory A. Clark, Reid R. Harrison
We present the design of an integrated circuit for wireless neural stimulation, along with bench-top and in-vivo experimental results. The chip has the ability to drive 100 individual stimulation electrodes with constant-current pulses of varying amplitude, duration, interphasic delay, and repetition rate. The stimulation is done using a biphasic (cathodic and anodic) current source, injecting and retracting charge from the nervous system. Wireless communication and power are achieved over a 2.765-MHz inductive link. Only two off-chip components are needed to operate the stimulator: a 10-nF capacitor to aid in power supply regulation and a coil for power and command reception. The chip was fabricated in a commercially available 0.6-mum 2P3M BiCMOS process. The chip was able to activate motor fibers to produce muscle twitches via a Utah Slanted Electrode Array implanted in cat sciatic nerve, and to activate sensory fibers to recruit evoked potentials in somatosensory cortex.
我们提出了一种用于无线神经刺激的集成电路的设计,以及实验台上和体内的实验结果。该芯片能够驱动100个具有不同振幅、持续时间、相间延迟和重复率的恒流脉冲的单独刺激电极。刺激是使用双相(阴极和阳极)电流源,从神经系统注入和收回电荷。无线通信和电源是在2.765 mhz的感应链路上实现的。操作刺激器只需要两个片外组件:一个用于电源调节的10-nF电容器和一个用于电源和命令接收的线圈。该芯片采用市售的0.6 μ m 2P3M BiCMOS工艺制造。通过植入猫坐骨神经的犹他倾斜电极阵列,该芯片能够激活运动纤维产生肌肉抽搐,并激活感觉纤维以招募体感觉皮层的诱发电位。
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引用次数: 9
Forward error correcting biosensors: Modeling, algorithms and fabrication 前向纠错生物传感器:建模、算法和制造
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696921
Yang Liu, E. Alocilja, S. Chakrabartty
Advances in micro-nano-biosensor fabrication are enabling the integration of a large number of biological recognition elements within a single package. As a result, hundreds to millions of tests can be performed simultaneously and can facilitate rapid detection of multiple pathogens in a given sample. However, it is an open question as to how to exploit the high-dimensional nature of the multi-pathogen testing for improving the detection reliability of typical biosensor systems. Our research over the past few years has addressed this question and in this paper we briefly summarize our approach. Our underlying principle is based on a forward error correcting (FEC) biosensor where redundant patterns are synthetically encoded on the biosensor. A decoding algorithm then exploits this redundancy to compensate for systematic errors due to experimental variations and for random errors due to stochastic biomolecular interactions. The key milestones in this research are : (a) fabrication and modeling of biomolecular circuit elements used for constructing the FEC biosensor; (b) development of a simulation environment for rapid evaluation of encoding/decoding algorithms and (c) development of a ldquoco-detectionrdquo protocol that exploits non-linear interaction between different biomolecular circuit elements. As a proof-of-concept our study and experimental results have been based on a conductimetric lateral flow immunosensor that uses antigen-antibody interaction in conjunction with a polyaniline transducer to detect the presence or absence of pathogens in a given sample.
微纳米生物传感器制造的进步使大量的生物识别元件集成在一个单一的封装。因此,可以同时进行数亿次检测,并有助于在给定样品中快速检测多种病原体。然而,如何利用多病原体检测的高维特性来提高典型生物传感器系统的检测可靠性是一个悬而未决的问题。我们在过去几年的研究已经解决了这个问题,在本文中我们简要地总结了我们的方法。我们的基本原理是基于前向纠错(FEC)生物传感器,其中冗余模式被合成编码在生物传感器上。然后,解码算法利用这种冗余来补偿由于实验变化引起的系统误差和由于随机生物分子相互作用引起的随机误差。本研究的关键里程碑是:(a)用于构建FEC生物传感器的生物分子电路元件的制造和建模;(b)开发用于快速评估编码/解码算法的模拟环境;(c)开发利用不同生物分子电路元件之间非线性相互作用的ldquoco-detectionrdquo协议。作为概念验证,我们的研究和实验结果基于电导侧流免疫传感器,该传感器使用抗原-抗体相互作用与聚苯胺传感器结合来检测给定样品中病原体的存在或不存在。
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引用次数: 3
An UWB system for wireless endoscope 一种用于无线内窥镜的超宽带系统
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696903
Chul Kim, S. Nooshabadi, T. Lehmann
This paper presents the integrated circuit design of an ultra-wideband (UWB) transceiver for a wireless endoscope that enables real-time diagnosis with high resolution images. The implemented UWB transceiver is a non-coherent transmit reference (TR) architecture with differential binary phase shift keying (DBPSK) modulation. All-digital pulse generator (PG) and merged radio frequency (RF) front end including low-noise amplifier (LNA), mixer and low-pass filter (LPF) have been proposed and implemented along with the analog baseband and LC-voltage controlled oscillator (VCO) using 0.18 mum digital CMOS process.
本文介绍了一种用于无线内窥镜的超宽带(UWB)收发器的集成电路设计,该收发器可实现高分辨率图像的实时诊断。所实现的超宽带收发器是采用差分二相移键控(DBPSK)调制的非相干发射参考(TR)架构。采用0.18 μ m数字CMOS工艺,提出并实现了全数字脉冲发生器(PG)和合并射频(RF)前端,包括低噪声放大器(LNA)、混频器和低通滤波器(LPF),以及模拟基带和lc压控振荡器(VCO)。
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引用次数: 3
Experimental thermal study of a TET system for implantable biomedical devices 植入式生物医学装置TET系统的热实验研究
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696887
T. Dissanayake, D. Budgett, P. Hu, S. Malpas
Power can be transferred across the skin using time varying magnetic fields to energize implantable medical devices. One of the most important concerns is the temperature rise caused by power loss and heating of such TET (Transcutanoues Energy Transfer) systems. This paper presents an experimental study of a TET system implanted in a sheep. The temperature rise in the internal and external coils of a TET system is analysed for power delivery in the 7W to 25W range. A power loss analysis of the overall system for three different loading conditions has been carried out and comparisons are presented. The TET system presented operates with an efficiency of 80.5% and a temperature rise of 2degC was observed in the implanted secondary coil when delivering 7W of power to the load.
能量可以通过随时间变化的磁场在皮肤上传输,从而为植入式医疗设备供电。最重要的问题之一是这种TET(经皮能量传输)系统的功率损失和加热引起的温度升高。本文介绍了在绵羊体内植入TET系统的实验研究。在功率输出范围为7W至25W的情况下,对TET系统内部和外部线圈的温升进行了分析。对整个系统在三种不同负载条件下的功率损耗进行了分析,并进行了比较。所提出的TET系统的工作效率为80.5%,当向负载提供7W的功率时,在植入的二次线圈中观察到2℃的温升。
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引用次数: 17
Circuits design and nano-structured electrodes for drugs monitoring in personalized therapy 个性化治疗中药物监测的电路设计和纳米结构电极
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696940
S. Carrara, A. Cavallini, G. De Micheli, V. Shumyantseva, A. Archakov, J. Olivo, L. Benini
Drug development and personalized therapy require accurate and frequent monitoring of the metabolic response by living tissues to treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecule cocktails, direct monitoring of the patientpsilas drugs metabolism is essential as the metabolic pathways efficacy is highly variable on a patient-by-patient basis. Currently, there are no fully mature point-of-care bio-sensing systems for drugs metabolism monitoring directly in blood. The aim of the paper is to investigate solutions to develop point-of-care systems for drugs monitoring in personalized therapy. P450 enzymes are the considered probe molecules as they are key proteins directly involved in drugs metabolism of humans. Sensitivity improvement is ensured by means of enzyme integration onto electrodes structured with carbon nanotubes. Component Off-The-Shelf (COTS) based circuits design is investigated toward bio-chip development. Results show that the proposed circuitry is suitable for the aim and confirm that nanotubes are detection enhancers.
药物开发和个性化治疗需要准确和频繁地监测活组织对治疗的代谢反应。在高风险副作用的情况下,例如使用干扰抗癌分子鸡尾酒治疗,直接监测患者体内药物代谢是必不可少的,因为代谢途径的功效在每个患者的基础上都是高度可变的。目前,还没有完全成熟的即时生物传感系统用于直接监测血液中的药物代谢。本文的目的是研究解决方案,以开发点护理系统的药物监测个性化治疗。P450酶是直接参与人体药物代谢的关键蛋白,被认为是探针分子。通过将酶整合到碳纳米管结构的电极上,确保了灵敏度的提高。研究了面向生物芯片开发的基于元器件现货(COTS)的电路设计。实验结果表明,所提出的电路符合目标,并证实了纳米管是检测增强器。
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引用次数: 5
Computing lightness constancy with an APS-based silicon retina 用基于aps的硅视网膜计算亮度常数
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696909
K. Shimonomura, T. Yagi
A silicon retina is an intelligent vision sensor that can execute real-time image pre-processing by using a parallel analog circuit that mimics the structure of the neuronal circuits in a vertebrate retina. In order to enhance robustness against changes in lighting conditions, we designed and fabricated a frame-based, wide dynamic range silicon retina with an active pixel sensor that approximates the logarithmic illumination-to-voltage transfer characteristics by using a time-dependent stepped reset voltage technique. The chip in this study realized dynamic range wide enough for perceiving objects in both indoor and outdoor environments. Moreover, the combination of the logarithmic-like photosensor and the Laplacian-Gaussian-like filtering by a resistive network in the chip produces the response with lightness constancy, that is, the response of the chip depends only on the contrast of the reflectance of objects, and not on the changes in illumination. The present silicon retina is suitable for the front end of the vision system in autonomous mobile robots in the real world.
硅视网膜是一种智能视觉传感器,它可以通过模拟脊椎动物视网膜中神经元电路结构的并行模拟电路来执行实时图像预处理。为了增强对光照条件变化的鲁棒性,我们设计并制造了一种基于帧的、宽动态范围的硅视网膜,它带有一个主动像素传感器,通过使用时间相关的阶跃复位电压技术来近似对数光照-电压转移特性。本研究的芯片实现了足够宽的动态范围,可以在室内和室外环境中感知物体。此外,芯片中的类对数光敏传感器与电阻网络的类拉普拉斯-高斯滤波相结合,产生了具有亮度常数的响应,即芯片的响应仅取决于物体反射率的对比,而不取决于光照的变化。目前的硅视网膜适用于现实世界中自主移动机器人视觉系统的前端。
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引用次数: 3
Feature extraction using an AM-FM model for gait pattern classification 基于AM-FM模型的特征提取步态模式分类
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696865
Ning Wang, E. Ambikairajah, B. Celler, N. Lovell
This paper describes classification of gait patterns from a waist-mounted triaxial accelerometer. A feature extraction technique using empirical mode decomposition (EMD) and an amplitude/frequency modulation (AM-FM) model is proposed for the classification of walking activities from accelerometry data. A set of novel features, including AM, instantaneous frequency (IF) and instantaneous amplitude (IA), representing the walking patterns were obtained based on a second-order all-pole resonator. The back-end of the system was a 32-mixture Gaussian Mixture Model (GMM) classifier. An overall classification error rate of 4.88% was achieved for the five different human gait patterns referring to walking on flat levels, walking up and down paved ramps and walking up and down stairways.
本文描述了一种腰装式三轴加速度计对步态模式的分类。提出了一种基于经验模态分解(EMD)和幅频调制(AM-FM)模型的特征提取技术,用于从加速度测量数据中对步行活动进行分类。基于二阶全极谐振器,得到了一组新颖的特征,包括AM、瞬时频率(IF)和瞬时幅度(IA),代表了行走模式。该系统的后端是一个32混合高斯混合模型(GMM)分类器。在平地上行走、在铺砌的斜坡上行走、在楼梯上行走这五种不同的步态模式下,总体分类错误率为4.88%。
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引用次数: 7
期刊
2008 IEEE Biomedical Circuits and Systems Conference
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