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2008 IEEE Biomedical Circuits and Systems Conference最新文献

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Conveying tactile feedback using a model of mechanotransduction 使用机械转导模型传递触觉反馈
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696893
S. Bensmaia, Sung Soo Kim, A. Sripati, R. J. Vogelstein
In order to develop effective neural prostheses for the hand, it is necessary to characterize the tactile information conveyed by the hand to the brain. Here we present a model that predicts the neural activity evoked by vibratory stimuli in the three types of mechanoreceptive fibers that innervate the glabrous skin of the hand. The model takes as input the position of the stimulus as a function of time, along with its first (velocity), second (acceleration) and third (jerk) derivatives. This input is filtered and passed through an integrate-and-fire mechanism to generate a train of spikes as output. By fitting the model to the activity of the three fiber types, we found that activity in each fiber type is best accounted for by specific stimulus combinations. The major conclusion of this study is that the timing of individual spikes evoked in mechanoreceptive fibers innervating the hand can be accurately predicted using an integrate-and-fire model. This model constitutes an important first step towards tactile neural prostheses.
为了开发有效的手部神经义肢,有必要对手部传递给大脑的触觉信息进行表征。在这里,我们提出了一个模型,预测由振动刺激引起的神经活动在三种类型的机械感受纤维,支配无毛的手的皮肤。该模型将刺激的位置作为时间的函数,以及它的第一阶导数(速度)、第二阶导数(加速度)和第三阶导数(加速度)作为输入。该输入经过过滤,并通过集成-发射机制生成一系列尖峰作为输出。通过将模型拟合到三种纤维类型的活动中,我们发现每种纤维类型的活动最好由特定的刺激组合来解释。本研究的主要结论是,在支配手部的机械感受纤维中诱发的单个尖峰的时间可以使用整合-发射模型准确地预测。这个模型是触觉神经假肢重要的第一步。
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引用次数: 15
Low-threshold voltage multipliers based on floating-gate charge-pumps 基于浮栅电荷泵的低阈值电压乘法器
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696910
Chenling Huang, S. Chakrabartty
The paper presents a low-threshold voltage multiplier circuit that can be used for harvesting energy from ambient radio-frequency (RF) signals. At the core of the circuit is a charge-pump based on CMOS floating-gate transistor diodes (FGTD) whose threshold voltage can be adjusted using indirect programming. We show that the diodes can achieve threshold voltages less than 50 mV, which is typically less than the conventional Schottky diodes fabricated in an equivalent process. A prototype of a 5-stage charge-pump is fabricated in a standard 0.5-mum CMOS process (Vth = 0.7 V and -0.9 V for nMOS and pMOS transistors respectively). Measurement results validate the functionality of the prototype for multiplying and regulating sub-threshold input signals. Using a 5-stage charge-pump we demonstrate operation at less than 300 mV input signal range with an operating frequency ranging from 1-4 MHz.
本文提出了一种低阈值电压倍增电路,可用于从环境射频信号中收集能量。该电路的核心是一个基于CMOS浮栅晶体管二极管(FGTD)的电荷泵,其阈值电压可以通过间接编程来调节。我们表明,二极管可以达到小于50 mV的阈值电压,这通常低于在等效工艺中制造的传统肖特基二极管。采用标准的0.5 μ m CMOS工艺(nMOS和pMOS晶体管的Vth分别为0.7 V和-0.9 V)制作了5级电荷泵的原型。测量结果验证了该原型对亚阈值输入信号的倍增和调节功能。使用5级电荷泵,我们演示了在小于300 mV的输入信号范围内工作,工作频率范围为1-4 MHz。
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引用次数: 4
Chemical stimulation of Aplysia californica ganglion with microfluidic signal generators 微流控信号发生器对加利福尼亚海杉神经节的化学刺激
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696935
F. Azizi, C. Mastrangelo, Hui Lu, H. Chiel
We implemented a microfluidic signal generator chip for the in-vitro study of the nervous system of Aplysia californica under localized chemical stimulation. The PDMS chip implements a one-bit pulse-code modulator that digitally controls the concentration of the non-hydrolysable cholinergic agonist carbachol injected directly above a ganglion. The chip was successful in inducing a burst of ingestive patterns.
我们实现了一种微流控信号发生器芯片,用于局部化学刺激下加利福尼亚海百合神经系统的体外研究。PDMS芯片实现了一个位脉冲编码调制器,该调制器以数字方式控制直接注射在神经节上方的非水解胆碱能激动剂碳醇的浓度。芯片成功地诱导了一种摄食模式的爆发。
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引用次数: 1
A CMOS integrated bacterial sensor for rapid detection of Pseudomonas aeruginosa 一种用于铜绿假单胞菌快速检测的CMOS集成细菌传感器
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696912
N. Nikkhoo, C. Mann, P. Gulak, K. Maxwell
An integrated bacterial detection chip is implemented in 0.18 mum CMOS technology. The chip has been tested using pyocins as biological detecting elements along with the study of electrical noise generated in an integrated nanowell to detect the presence of two different bacterial clinical isolates of Pseudomonas aeruginosa. The chip successfully identifies the presence of bacterial strains sensitive to the pyocin in less than 10 minutes. The effect of bacterial cell concentration is also presented in the experimental results. The chip consumes 122 muW from 3.3 V supply for two recording channels and occupies an area of 0.48 mm2 in a 0.18 mum standard CMOS process.
采用0.18 μ m CMOS技术实现了集成式细菌检测芯片。该芯片已经使用pyocins作为生物检测元件进行了测试,同时研究了集成纳米孔中产生的电噪声,以检测铜绿假单胞菌两种不同细菌临床分离株的存在。该芯片在不到10分钟的时间内成功识别出对脓毒杆菌素敏感的细菌菌株。实验结果也显示了细菌细胞浓度的影响。该芯片从3.3 V电源消耗122 muW用于两个记录通道,在0.18 μ m标准CMOS工艺中占地0.48 mm2。
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引用次数: 4
Real-time filtering technique to remove ECG interference from recorded esophageal EMG 实时滤波技术去除食管肌电图记录的心电干扰
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696864
Bassam Rhou, Mohamad Sawan, T. Desilets, François Bellemare
Electromyogram (EMG) is used in various circumstances such as diagnostic and prosthesis control. This paper deals with the diaphragmatic electromyogram (EMGdi) as a controller of mechanical ventilation. However, recorded EMGdi signals are always contaminated by electrocardiogram (ECG). Cancellation of the ECG contamination, especially in real-time, is not a simple operation because the spectra of EMG and ECG overlap. We present in this paper an EMGdi acquisition system implementing an efficient real-time EMG processing technique. This system includes an esophageal catheter and a control unit with Bluetooth link for communication with a user interface. The ECG cancellation part includes two 8-bit microcontrollers communicating via a SPI interface and receiving and sending data via two RS232 serial links and can be easily adapted to be used for any application which needs to eliminate ECG artifacts from EMG. The simulation and experimental results show that the chosen filtering technique gives good results on diaphragmatic EMG and can operate in a hardware system.
肌电图(EMG)用于各种情况,如诊断和假肢控制。本文讨论了膈肌电图作为机械通气的控制器。然而,记录的EMGdi信号总是受到心电图(ECG)的污染。由于肌电图和心电图的频谱重叠,消除心电污染,特别是在实时情况下,并不是一个简单的操作。本文提出了一种实现高效实时肌电信号处理技术的EMGdi采集系统。该系统包括一个食管导管和一个带有蓝牙链路的控制单元,用于与用户界面通信。心电消除部分包括两个8位微控制器,通过SPI接口通信,通过两个RS232串行链路接收和发送数据,可以很容易地适应用于任何需要从肌电图中消除心电伪影的应用。仿真和实验结果表明,所选择的滤波技术对膈肌肌电信号具有良好的滤波效果,可以在硬件系统中运行。
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引用次数: 8
Dynamical digital silicon neurons 动态数字硅神经元
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696931
A. Cassidy, A. Andreou
We present an array of dynamical digital silicon neurons implementing the Izhikevich neuron model. The FPGA based array consists of 32 physical neurons, each time multiplexing the state of 8 virtual neurons, for a total of 256 independent neurons. The neural array operates at 5,000 times faster than real time, performing over 20.48 GOPS (giga operations per second). It is intended for neural simulation acceleration, neural prostheses, and neuromorphic systems.
我们提出了一组动态数字硅神经元,实现了Izhikevich神经元模型。基于FPGA的阵列由32个物理神经元组成,每次复用8个虚拟神经元的状态,总共256个独立神经元。神经阵列的运行速度比实时快5000倍,执行超过20.48 GOPS(每秒千兆操作)。它适用于神经模拟加速、神经假体和神经形态系统。
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引用次数: 68
Mismatch reduction with relative reset in integrate-and-fire photo-pixel array 基于相对复位的集成发射像素阵列失配减少方法
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696928
J.A.M. Olsson, P. Hafliger
We have reduced the mismatch error in a bio-inspired vision sensor, of the kind that is popularly known as dasiaoctopus retinapsila. Mismatch and noise reduction techniques developed for traditional imagers, like correlated double sampling (CDS), cannot be applied to this frame-free asynchronous vision sensor. In an dasiaoctopus retinapsila, each self timed pixel integrates photo current until a threshold is reached, whereupon it creates a pixel-event and is reset. To reduce threshold mismatch, 1/f and reset noise in this implementation, pixels are not reset to a common baseline but to a level that is relative to the individual firing threshold. This is achieved by subtracting a fixed charge from the integrating node. The matching of that charge is dependent on the matching of a carefully designed capacitor. Monte Carlo simulations of the pixel with manufacturer mismatch statistic parameters predicted a total pixel mismatch of only 0.26%. The physical implementation on a AMS 0.35 micro-meter ASIC with a resolution of 74 times 74 pixels achieved a mismatch of below 1%.
我们已经减少了生物视觉传感器的不匹配误差,这种传感器通常被称为视网膜残肢。为传统成像技术开发的失配和降噪技术,如相关双采样(CDS),不能应用于这种无帧异步视觉传感器。在dasiap章鱼视网膜中,每个自定时像素集成光电流,直到达到阈值,然后它创建一个像素事件并重置。为了减少阈值不匹配、1/f和复位噪声在这个实现中,像素不是重置到一个共同的基线,而是重置到一个相对于单个触发阈值的水平。这是通过从积分节点减去固定电荷来实现的。电荷的匹配取决于精心设计的电容器的匹配。蒙特卡罗模拟与制造商失配统计参数的像素预测总像素失配仅为0.26%。在分辨率为74 × 74像素的AMS 0.35微米ASIC上的物理实现实现了低于1%的不匹配。
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引用次数: 9
Reverse engineering the principal image processing architectures of the Macula Lutea within the human retina 逆向工程的主要图像处理架构黄斑在人类视网膜
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696918
D. Banks, C. Toumazou
We present here a biomorphic CMOS colour opponent retinal processing algorithm and chip, representing the image-processing of the human macula lutea, with simulated and measured results. This chip has colour selective photodiodes (representing blue and red retinal cone cells) implemented without any post processing, using the intrinsic absorption of silicon as colour filter, and allowing double colour opponent receptive field implementation. Utilising two convolution stages (an improved resistive network with feedback that inhibits lateral spreading under high intensity light conditions, and a current-mode bidirectional 3times3 distributed reduced Laplacian filter), allowing asymmetric and effective Laplacian filter implementations of any size from 3times3 to larger than the array itself. The current-mode circuitry represents the macula ganglion, bipolar cell interface, and the resistive network high light intensity inhibition has been observed within retinal horizontal cell networks. This work is directly relevant to distributed focal plane image processing systems, either as stand-alone feature extraction devices where low space and power are essential, or as a retinal replacement aid for the visually impaired.
本文提出了一种生物形态CMOS彩色对手视网膜处理算法和芯片,代表了人类黄斑的图像处理,并进行了模拟和测量结果。该芯片具有颜色选择光电二极管(代表蓝色和红色视网膜锥细胞),没有任何后处理,使用硅的本征吸收作为颜色过滤器,并允许双色对手接受野实现。利用两个卷积阶段(一个带有反馈的改进电阻网络,在高强度光照条件下抑制横向扩散,以及一个电流模式双向3times3分布的简化拉普拉斯滤波器),允许实现从3times3到比阵列本身更大的任何尺寸的不对称和有效的拉普拉斯滤波器。电流模式电路代表黄斑神经节、双极细胞界面和电阻网络,在视网膜水平细胞网络中观察到高光强抑制。这项工作与分布式焦平面图像处理系统直接相关,无论是作为独立的特征提取设备,在低空间和功率是必不可少的,还是作为视障人士的视网膜替代辅助设备。
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引用次数: 0
Design and development of an active Laplacian sensor for non-invasive recordings of the intestinal bioelectrical signal 一种用于无创记录肠道生物电信号的有源拉普拉斯传感器的设计与开发
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696878
G. Prats-Boluda, J. Garcia-Casado, J. L. Martinez-de-Juan, Y. Ye
Abdominal surface recordings of the electroenterogram (EEnG) could be a noninvasive solution to study the intestinal motility. However, surface EEnG is a weak signal (muV) sensitive to physiological interferences such as ECG and respiration. The goal of this work has been to develop a modular Laplacian sensor to enhance the quality of conventional bipolar recordings. This sensor is made up by two parts: the passive part which consist of 3 concentric Ag/AgCl ring electrodes; and the active part which is a battery-powered signal conditioning circuit. Each part is etched in a different printed circuit board (PCB), and they are connected to each other by SMT connectors. So that, the sensing part can be treated independently for its maintenance and replacement, while the active part can be reused. In a preliminary recording session, the slow wave (SW) component of the EEnG was identified in the signal provided by the Laplacian sensor. Moreover, this signal proved to be less affected by respiration and ECG interference.
腹部肠电图(EEnG)是研究肠道运动的一种无创方法。然而,表面eeg是一种弱信号(muV),对ECG和呼吸等生理干扰敏感。这项工作的目标是开发一个模块化的拉普拉斯传感器,以提高传统双极记录的质量。该传感器由两部分组成:无源部分由3个同心Ag/AgCl环形电极组成;有源部分是电池供电的信号调理电路。每个部件都蚀刻在不同的印刷电路板(PCB)上,并通过SMT连接器相互连接。这样,传感部分可以独立处理,进行维护和更换,而活动部分可以重复使用。在初步记录阶段,在拉普拉斯传感器提供的信号中识别出了eeg的慢波(SW)分量。此外,该信号受呼吸和心电干扰的影响较小。
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引用次数: 3
An efficient algorithm and architecture for medical image segmentation and tumour detection 一种用于医学图像分割和肿瘤检测的高效算法和体系结构
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696898
M. S. Sharif, Abdul N. Sazish, A. Amira
Medical image segmentation is very important for radiotherapy planning and cancer diagnosis. There are many techniques for medical image segmentation based on thresholding, classification, and multiresolution analysis (MRA). This paper proposes a system based on MRA and artificial intelligence techniques (AI) for tumour segmentation in DICOM images. The slowest parts of the proposed system have been accelerated using field programmable gate arrays (FPGA). Hardware implementation of Haar wavelet transform based factorization approach (HWTF) on reconfigurable hardware using distributed arithmetic (DA) principles is presented. The developed architecture can be integrated into a system for automatic detection and segmentation of tumour in positron emission tomography (PET) images.
医学图像分割对放疗计划和肿瘤诊断具有重要意义。基于阈值分割、分类和多分辨率分析(MRA)的医学图像分割技术有很多。本文提出了一种基于MRA和人工智能技术的DICOM图像肿瘤分割系统。采用现场可编程门阵列(FPGA)对系统中最慢的部分进行了加速。提出了一种基于Haar小波变换的因子分解方法(HWTF)在可重构硬件上的硬件实现。所开发的体系结构可以集成到正电子发射断层扫描(PET)图像中肿瘤的自动检测和分割系统中。
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引用次数: 5
期刊
2008 IEEE Biomedical Circuits and Systems Conference
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