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2008 IEEE Biomedical Circuits and Systems Conference最新文献

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Nanoscale design of ultrastrong materials by LBL assembly 基于LBL组装的超强材料纳米级设计
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696944
P. Podsiadlo, N. Kotov
The preparation of a high-strength and highly transparent thin-film nanocomposites via layer-by-layer assembly technique from poly(vinyl alcohol) (PVA) and Na+-montmorillonite clay nanosheets is reported here. We show that a high density of weak bonding interactions between the polymer and the clay particles: hydrogen, dipole-induced dipole, and van der Waals undergoing break-reform deformations, can lead to high strength nanocomposites: ultimate tensile strength, sigmaUTS = 150 MPa and in-plane modulus of elasticity, E' = 13 GPa. Further introduction of covalent or ionic bonds into the polymeric matrix creates a double network of bonds which dramatically increases the mechanical properties to values as high as sigmaUTS = 400 MPa and E' = 110 GPa. The resulting nanocomposites can be applied as robust multifunctional coatings and free-standing membranes for micromechanical or microfluidic devices, biosensors, actuators, valves, and implantable biomedical devices.
以聚乙烯醇(PVA)和Na+蒙脱土纳米片为原料,采用逐层组装技术制备了高强度、高透明的薄膜纳米复合材料。研究表明,聚合物与粘土颗粒之间的高密度弱键相互作用:氢、偶极子诱导的偶极子和发生断裂-转化变形的范德华,可以产生高强度的纳米复合材料:极限拉伸强度sigmats = 150 MPa,面内弹性模量E' = 13 GPa。在聚合物基体中进一步引入共价键或离子键会形成双键网络,从而显著提高机械性能,sigmats = 400 MPa, E' = 110 GPa。所得到的纳米复合材料可以用作微机械或微流体装置、生物传感器、致动器、阀门和植入式生物医学装置的坚固多功能涂层和独立膜。
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引用次数: 1
Practical considerations for the use of a Howland current source for neuro-stimulation 使用霍兰德电流源进行神经刺激的实际考虑
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696867
P. Pouliquen, J. Vogelstein, R. Etienne-Cummings
We analyze the Howland current source circuit topology in detail with regards to non-ideal circuit component properties. This circuit is one of the few which can be built with a small number of discrete components, offers very good performance due to the use of an operational amplifier, and supplies true symmetric bi-directional currents, and is hence well suited for use in the multi-channel electrical stimulation of nerve fibers and neurons.
从非理想电路元件的特性出发,详细分析了Howland电流源电路拓扑结构。该电路是少数可以用少量分立元件构建的电路之一,由于使用了运算放大器,提供了非常好的性能,并提供了真正的对称双向电流,因此非常适合用于神经纤维和神经元的多通道电刺激。
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引用次数: 22
Design of an integrated sensor for noninvasive optical mammography based on frequency-domain NIR spectroscopy 基于频域近红外光谱的无创光学乳房x线照相术集成传感器设计
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696905
Ruida Yun, V. Joyner
Time-resolved techniques for optical spectroscopy are emerging as a promising diagnostic tool for mammography providing richer information content of optical images and improved tumor detectability. This paper presents the design of an integrated optical sensor for phase and amplitude detection of RF-modulated optical signals up to 110 MHz in the near-infrared (NIR) region (650-850 nm) for use in frequency-domain instruments that measure both amplitude and phase changes in photon migration between source and detector. The sensor consists of an NIR-sensitive photodetector monolithically integrated with front-end analog amplifier and signal processing circuitry for amplitude and phase detection in an unmodified CMOS process. The differential transimpedance amplifier (TIA) achieves a transimpedance-bandwidth product of 28 THzOmega and input-referred current noise of 1.92 pA/radicHz at 110 MHz. The amplitude detector exhibits 49.2 mV/muA resolution with 0.5% linearity and 26 dB dynamic range. The proposed phase detector can detect 360 degree phase difference with phase resolution of 5 mV/degree. The sensor is implemented in a 0.18 mum CMOS technology and consumes 22.5 mW from a 1.8 V supply voltage. The integrated sensor presented is envisaged as a building block towards a low-power, low-cost optical sensor array system for concurrent measurement of multiple tissue sites, thus improving spatial resolution.
时间分辨光谱学技术作为一种很有前途的乳房x线摄影诊断工具正在兴起,它提供了更丰富的光学图像信息内容,提高了肿瘤的可检测性。本文介绍了一种集成光学传感器的设计,用于近红外(NIR)区域(650-850 nm)高达110 MHz的射频调制光信号的相位和幅度检测,用于测量光子在源和探测器之间迁移的幅度和相位变化的频域仪器。该传感器由一个nir敏感光电探测器、前端模拟放大器和用于幅度和相位检测的信号处理电路组成,采用未经修改的CMOS工艺。差分跨阻放大器(TIA)在110 MHz时实现了28 THzOmega的跨阻带宽乘积和1.92 pA/radicHz的输入参考电流噪声。振幅检测器的分辨率为49.2 mV/muA,线性度为0.5%,动态范围为26 dB。该鉴相器可以360度检测相位差,相位分辨率为5 mV/度。该传感器采用0.18 μ m CMOS技术,在1.8 V电源电压下消耗22.5 mW。该集成传感器被设想为一个低功耗、低成本的光学传感器阵列系统的组成部分,用于同时测量多个组织部位,从而提高空间分辨率。
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引用次数: 3
Analog Logic Automata 模拟逻辑自动机
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696906
Kailiang Chen, Jonathan Leu, Neil Gershenfeld
Analog logic circuits work on digital problems using an analog representation of the digital variables, relaxing the state space of the digital system from the vertices of a hypercube to the interior. This lets us gain speed, power, and accuracy over digital implementations. Logic automata are distributed, scalable and programmable digital computation media with local connections and logic operations. Here we propose analog logic automata (ALA), which relax binary constraints on logic automata states and introduce programmability into analog logic circuits. The localized interaction and scalability of the ALA provide a new way to do neuromorphic engineering, enabling systematic designs in a digital work flow. Low-power, biomedical, decoding and communication applications are described and a 3times3 ALA chip is prototyped, which works at 50 kHz, with a power consumption of 64 muW. With the chip configured as a programmable noise-locked loop (NLL), we obtain a bit error rate (BER) of 1E-7 at an SNR of -1.13 dB.
模拟逻辑电路使用数字变量的模拟表示来处理数字问题,将数字系统的状态空间从超立方体的顶点放宽到内部。这使我们能够获得比数字实现更快、更强大和更准确的性能。逻辑自动机是具有本地连接和逻辑操作的分布式、可扩展和可编程的数字计算媒体。本文提出了模拟逻辑自动机(ALA),它放宽了对逻辑自动机状态的二进制约束,并将可编程性引入模拟逻辑电路。ALA的局部交互和可扩展性为神经形态工程提供了一种新的方法,使数字化工作流程中的系统设计成为可能。描述了低功耗,生物医学,解码和通信应用,并原型化了3times3ala芯片,其工作频率为50 kHz,功耗为64 muW。将芯片配置为可编程噪声锁相环(NLL),在信噪比为-1.13 dB的情况下,我们获得了误码率(BER)为1E-7。
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引用次数: 6
Fully-integrated inductive power recovery front-end dedicated to implantable devices 全集成电感式电源回收前端,专用于植入式设备
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696885
F. Mounaim, M. Sawan, M. El-Gamal
Wirelessly powered implantable biomedical devices require a near-field inductive link to provide enough power for high current stimulation of large electrode-nerve impedances. In that situation, the induced voltage may be much larger than the compliance of low-voltage integrated circuits, especially during low-load conditions. In fact, most power recovery approaches limit the voltage with an inefficient off-chip solution using discrete components such as a Zener diode or a shunt regulator, or even on-chip voltage clipping. In this paper, we propose the approach where the induced voltage is not limited at all, using a high-voltage (HV) CMOS technology. In order to fully integrate the inductive power recovery stage, we report the design of a HV custom integrated circuit (IC) that includes a full-wave rectifier and a 10 V regulator using a multiple-outputs voltage reference. The IC has been fabricated in DALSA-C08G technology and the total silicon area including pads is 4 mm2. This front-end stage can be driven by an input voltage as high as 50 V. Measurement tests are successful as the HV regulator shows good response to a power-on 50 V step, and good stability in presence of large input variations.
无线供电的植入式生物医学设备需要一个近场感应链路,以提供足够的能量来刺激大的电极-神经阻抗。在这种情况下,特别是在低负载情况下,感应电压可能比低压集成电路的顺应性大得多。事实上,大多数功率恢复方法都是通过使用分立元件(如齐纳二极管或分流稳压器)甚至片上电压削波等低效的片外解决方案来限制电压的。在本文中,我们提出了一种完全不限制感应电压的方法,使用高压(HV) CMOS技术。为了充分集成感应功率恢复阶段,我们报告了一种高压定制集成电路(IC)的设计,该电路包括一个全波整流器和一个使用多输出基准电压的10 V稳压器。该集成电路采用DALSA-C08G技术制造,包括焊盘在内的总硅面积为4mm2。这个前端级可以由高达50 V的输入电压驱动。测量测试是成功的,因为高压稳压器对上电50 V步进表现出良好的响应,并且在存在大输入变化时表现出良好的稳定性。
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引用次数: 10
Integrated CMOS imager for pattern recognition 集成CMOS成像仪的模式识别
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696913
A. Sarje, S. Satsangi, A.C. Skipwith, J.-P. Chiang, P. Abshire
This paper presents an analog CMOS architecture for on-chip pattern recognition. The system comprises a CMOS imager in the front end followed by low power computation circuitry for determining a match between the captured image and image patterns stored in on-chip memory. The imager has a programmable kernel selector and correlated double sampling circuit for suppression of fixed pattern noise. The closeness of a successful match can be controlled by an input bias current. The prototype with a 6 times 6 pixel array in a 0.5 mum CMOS process is being implemented. This chip can be used for applications requiring dedicated pattern recognition.
本文提出了一种用于片上模式识别的模拟CMOS结构。该系统包括前端的CMOS成像仪,随后是用于确定捕获图像与存储在片上存储器中的图像模式之间的匹配的低功耗计算电路。成像仪具有可编程核选择器和相关双采样电路,用于抑制固定模式噪声。成功匹配的紧密程度可以通过输入偏置电流来控制。在0.5 μ m CMOS工艺中实现了6 × 6像素阵列的原型。该芯片可用于需要专用模式识别的应用。
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引用次数: 1
Readout circuit design for an EISCAP biosensor EISCAP生物传感器读出电路设计
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696877
H. Vemulachedu, S. Pavan, E. Bhattacharya
We present the design of readout electronics for an Electrolyte Insulator Semiconductor capacitor (EISCAP) sensor. The sensor detects the presence of bioanalytes by sensing the change in the pH of the electrolyte. Our technique uses an EISCAP relaxation oscillator embedded in a successive approximation analog-to-digital conversion algorithm to give a digital readout of the pH of the test solution. A microcontroller based pH readout instrument, incorporating calibration to account for sensor variations, is described. Experimental results that demonstrate the efficacy of our techniques are given.
我们设计了一种电解质绝缘体半导体电容(EISCAP)传感器的读出电子器件。传感器通过感应电解质pH值的变化来检测生物分析物的存在。我们的技术使用嵌入连续近似模数转换算法的EISCAP弛豫振荡器来给出测试溶液的pH值的数字读数。描述了一种基于微控制器的pH读数仪器,结合校准以考虑传感器变化。实验结果证明了该方法的有效性。
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引用次数: 3
Formant map counterpart in auditory processing based on cochlear pressure wave trajectories 基于耳蜗压力波轨迹的听觉加工中形成峰图对应
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696870
T. Harczos, S. Werner, G. Szepannek
It is known for a long time that vowels can be classified using spectrum analysis and formant map templates. But in systems having poor spectral resolution, e.g. in cochlear implants, it may be interesting to see if a map of vowel classes can be constructed based on temporal cues only. We present a bio-inspired approach to extract the shape of cochlear pressure wave trajectories for speech signals and provide a simple vowel classification method not requiring any spectral information directly. Experiments and results included in this study emphasize the importance of biotic cochlear delays and urge their application in future cochlear implant speech processing strategies.
很长一段时间以来,人们都知道元音可以使用频谱分析和构象图模板进行分类。但在频谱分辨率较差的系统中,例如在人工耳蜗中,看看是否可以仅基于时间线索构建元音类地图可能会很有趣。我们提出了一种生物启发的方法来提取语音信号的耳蜗压力波轨迹的形状,并提供了一种简单的元音分类方法,不需要任何直接的频谱信息。本研究的实验和结果强调了生物耳蜗延迟的重要性,并敦促其在未来人工耳蜗语音处理策略中的应用。
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引用次数: 0
High resolution imaging through integrated nanoholes image sensor 集成纳米孔图像传感器的高分辨率成像
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696920
T. Elkhatib, K. Salama
A new imaging sensor with high resolution independent of the image sensorpsilas pixel size is presented. This sensor combines an integrated nanohole patterned in the first metal layer within each pixel and it can be fabricated in any standard submicron CMOS process. The final high resolution image requires a relative scanning motion between the sensor and the object under test; this relative motion can be achieved in an optofluidic microscopy system whereas the sample flows in a microfluidic channel while the image sensor acquires the high resolution image. Here, we describe the concept of the presented high resolution imaging sensor and elaborate on the optofludic microscopy system as one example of its implementation for a real biomedical imaging application.
提出了一种与图像传感器像素大小无关的高分辨率图像传感器。该传感器在每个像素的第一金属层中结合了一个集成的纳米孔,并且可以在任何标准的亚微米CMOS工艺中制造。最终的高分辨率图像需要传感器和被测物体之间的相对扫描运动;这种相对运动可以在光流显微镜系统中实现,而样品在微流控通道中流动,而图像传感器获得高分辨率图像。在这里,我们描述了所提出的高分辨率成像传感器的概念,并详细介绍了光流体显微镜系统作为其在实际生物医学成像应用中实现的一个例子。
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引用次数: 0
Frequency controllable in vivo biological oscillators 频率可控体内生物振荡器
Pub Date : 2008-11-01 DOI: 10.1109/BIOCAS.2008.4696863
N. Neihart, B. House
This paper presents models and simulation results for two different tunable biological oscillators realized inside of the bacteria Escherichia Coli (E. coli). The first system considered is the Elowitz repressilator and simulations show that the period of oscillation can be varied between 151.4 minutes and 225.8 minutes. The second system is a relaxation oscillator whose period of oscillation varies between 61.8 minutes and 72.7 minutes. The period of oscillation of both oscillators is controlled using IPTG. These types of systems will be important in characterizing and developing models for the molecular and protein interactions within a biological cell.
本文介绍了在大肠杆菌内部实现的两种不同的可调生物振荡器的模型和仿真结果。第一个考虑的系统是Elowitz再调节器,仿真表明振荡周期可以在151.4分钟到225.8分钟之间变化。第二个系统是一个振荡周期在61.8 ~ 72.7分钟之间变化的弛豫振荡器。用IPTG控制两个振荡器的振荡周期。这些类型的系统对于描述和发展生物细胞内分子和蛋白质相互作用的模型非常重要。
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引用次数: 0
期刊
2008 IEEE Biomedical Circuits and Systems Conference
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