Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.96100
Justina Oluwatoyin Aleksovna Oguntimehin, Aizanat M. Jalalova, Kristina M. Krasnikova, O. V. Alekseenko, Ulyana Y. Senkovich, Sabina R. Zeynalova, Kuban
Aim. Our aim hereof is to assess the status of infectious morbidity in the pediatric population in the territory of the Russian Federation and the City of Krasnodar in the period 2021-2022 by an example of the State Health Institution “Pediatrics Polyclinic No 2”, Department of Health Care of the City of Krasnodar. Material and Methods. Our work has been completed with use of official statistical data of the Federal Service of the state statistics of the Russian Federation, the database of Rospotrebnadzor of the Krasnodar territory, statistical data set collections of FGBI “The Central Research Institute of the Management and Information of Public Health Care” at the Ministry of Health Care of the Russian Federation. A retrospective analysis was performed using data from the State Report “The state of sanitary and epidemiological welfare of the population in the Russian Federation in 2021”. Statistical processing was carried out using GraphPad Prism 5.0 and Word Excel. Results. According to the data on the sanitary and epidemiological well-being of the population, an increase in the number of cases of infectious and parasitic diseases was recorded in the Russian Federation in 2021. The sharp rise in the incidence of infectious diseases is directly related to the spread of the new COVID-19 infection. The incidence of ARVI among children in 2021 was 68,062.49 per 100,000 that is 15.4% higher than in 2020. In Krasnodar, there were 236,332 patients diagnosed with infectious diseases in 2021. According to the data submitted by Branch No. 2 of the Krasnodar City Pediatrics Hospital at the City Health Care Department, the overall morbidity of children in the first year of life in 2022 has decreased. No cases of diphtheria, pertussis, poliomyelitis, measles, and viral hepatitis B were recorded by the outpatient clinical institution during the study period. As a part of preventive measures, children are routinely vaccinated by the Pediatrics Hospital No. 2; at the end of 2022, 98.3% of children in risk groups had been successfully treated and were allowed to be vaccinated. Conclusion. Over the period 2021-2022, there has been a decline in the incidence of diseases in children in the first year of life in the Krasnodar Region. At the same time, the recorded overall occurrence rate of acute upper respiratory tract infections of multiple and unspecified localization remains high that is due to the difficulty of diagnosing them at the early stages of infection, and, as a result, the effectiveness of their treatment is low that may be accompanied by high mortality.
{"title":"Analysis of the infectious morbidity in the children's population in the city of Krasnodar","authors":"Justina Oluwatoyin Aleksovna Oguntimehin, Aizanat M. Jalalova, Kristina M. Krasnikova, O. V. Alekseenko, Ulyana Y. Senkovich, Sabina R. Zeynalova, Kuban","doi":"10.18137/cardiometry.2023.27.96100","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.96100","url":null,"abstract":"Aim. Our aim hereof is to assess the status of infectious morbidity in the pediatric population in the territory of the Russian Federation and the City of Krasnodar in the period 2021-2022 by an example of the State Health Institution “Pediatrics Polyclinic No 2”, Department of Health Care of the City of Krasnodar. Material and Methods. Our work has been completed with use of official statistical data of the Federal Service of the state statistics of the Russian Federation, the database of Rospotrebnadzor of the Krasnodar territory, statistical data set collections of FGBI “The Central Research Institute of the Management and Information of Public Health Care” at the Ministry of Health Care of the Russian Federation. A retrospective analysis was performed using data from the State Report “The state of sanitary and epidemiological welfare of the population in the Russian Federation in 2021”. Statistical processing was carried out using GraphPad Prism 5.0 and Word Excel. Results. According to the data on the sanitary and epidemiological well-being of the population, an increase in the number of cases of infectious and parasitic diseases was recorded in the Russian Federation in 2021. The sharp rise in the incidence of infectious diseases is directly related to the spread of the new COVID-19 infection. The incidence of ARVI among children in 2021 was 68,062.49 per 100,000 that is 15.4% higher than in 2020. In Krasnodar, there were 236,332 patients diagnosed with infectious diseases in 2021. According to the data submitted by Branch No. 2 of the Krasnodar City Pediatrics Hospital at the City Health Care Department, the overall morbidity of children in the first year of life in 2022 has decreased. No cases of diphtheria, pertussis, poliomyelitis, measles, and viral hepatitis B were recorded by the outpatient clinical institution during the study period. As a part of preventive measures, children are routinely vaccinated by the Pediatrics Hospital No. 2; at the end of 2022, 98.3% of children in risk groups had been successfully treated and were allowed to be vaccinated. Conclusion. Over the period 2021-2022, there has been a decline in the incidence of diseases in children in the first year of life in the Krasnodar Region. At the same time, the recorded overall occurrence rate of acute upper respiratory tract infections of multiple and unspecified localization remains high that is due to the difficulty of diagnosing them at the early stages of infection, and, as a result, the effectiveness of their treatment is low that may be accompanied by high mortality.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47860656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.134141
Elizaveta S. Shevchenko, Egor A. Pivovarov, E. V. Dmitrieva, Pirogov
The paper considers individual approaches to the provision of emergency psychiatric care in emergency situations. The authors believe that emergency psychological, psychiatric and psychotherapeutic care is an important component of the healthcare system and plays an important role in providing timely assistance to people facing crisis situations, including mental disorders, suicidal thoughts, traumatic events and other problems. The main task of emergency psychological, psychiatric and psychotherapeutic care is to provide quick and effective assistance in an emergency situation when every minute matters and can save a life. In addition, emergency psychological, psychiatric and psychotherapeutic care can also help prevent the development of mental health-related diseases and provide patients with access to the necessary resources and treatment. It is important to note that urgent psychological, psychiatric and psychotherapeutic care should be available to everyone who needs it, regardless of age, gender, social status and other factors. At the same time, it is important to take into account the cultural and ethical characteristics of each patient and provide them with an individual approach and high-quality care.
{"title":"Separate approaches to the provision of emergency psychological, psychiatric and psychotherapeutic assistance in emergency situations","authors":"Elizaveta S. Shevchenko, Egor A. Pivovarov, E. V. Dmitrieva, Pirogov","doi":"10.18137/cardiometry.2023.27.134141","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.134141","url":null,"abstract":"The paper considers individual approaches to the provision of emergency psychiatric care in emergency situations. The authors believe that emergency psychological, psychiatric and psychotherapeutic care is an important component of the healthcare system and plays an important role in providing timely assistance to people facing crisis situations, including mental disorders, suicidal thoughts, traumatic events and other problems. The main task of emergency psychological, psychiatric and psychotherapeutic care is to provide quick and effective assistance in an emergency situation when every minute matters and can save a life. In addition, emergency psychological, psychiatric and psychotherapeutic care can also help prevent the development of mental health-related diseases and provide patients with access to the necessary resources and treatment. It is important to note that urgent psychological, psychiatric and psychotherapeutic care should be available to everyone who needs it, regardless of age, gender, social status and other factors. At the same time, it is important to take into account the cultural and ethical characteristics of each patient and provide them with an individual approach and high-quality care.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44982708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.5462
O. Kit, I. Kaplieva, E. Frantsiyants, L. Trepitaki, V. Bandovkina, Y. Pogorelova, I. Goroshinskaya, E. Surikova, I. Neskubina, G. Zhukova, A. Shikhlyarova, M. Engibaryan, T. V. Ausheva, V. L. Volkova, M. Gusareva, P. Kachesova
Aims: to study the features of the functioning of the hypothalamic-pituitary-gonadal axis (HPGA) regulation in male rats at the stages of liver metastasizing. Materials and methods. Our research work was performed in 30 outbred male rats. Metastases in the liver were produced by implantation of sarcoma 45 (S45) cells into the spleen, which was previously positioned under the skin. The time spans of the study are 5 weeks (the pre-metastatic stage) and 7 weeks (the metastatic stage) after tumor cell transplantation. In the tissues, the content of the following hormones was determined by RIA: luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), total testosterone (Ttot), progesterone (P4); by ELISA we determined the content of the following hormones: gonadotropin-releasing hormone (GnRH), free testosterone (Tfr) and estrone (E1). Results. At all stages of the study, the level of GnRH in the hypothalamus decreased by more than 2.0 times; in the pituitary gland, the hormone levels had multidirectional dynamics: LH decreased by 1.6 times, and FSH increased by more than 6.0 times. Liver metastases were characterized by high levels of E1 and Ttot. In the gonads, a high level of P4 was recorded and concentrations of both forms of testosterone were reduced. The concentrations of E2 (by 1.6 times), Tfr (by 4.8 times) increased in blood, and the level of Ttot decreased (by 1.9 times). The salient features of HPGA in the presence of two metastasis sites (liver and lungs) were as follows: in blood, a 2.0 times lower increase in the LH and Tfr contents, a 1.6 times greater increase in E2, an increase in P4 (2.6 times), 1, 4 times lower level of FSH; in the gonads, there are found lower levels of P4, E1, but higher levels of Tfr and Ttot; in liver metastases, a greater increase in P4 (5.2 times), E1 (2.2 times) and Tfr (2.0 times) is recorded. Conclusion. Metastasizing to the liver was accompanied by activation of HPGA with the maximum accumulation of reactogenic E1 in liver metastases in rats with two metastasis sites that may indicate their more severe malignancy and ability to metastasize to the lungs.
{"title":"Differences in the functioning of the hypothalamic-pituitarygonadal axis of regulation in male rats at one (liver) site and two (liver and lungs) sites of metastasis of sarcoma 45 in the experiment","authors":"O. Kit, I. Kaplieva, E. Frantsiyants, L. Trepitaki, V. Bandovkina, Y. Pogorelova, I. Goroshinskaya, E. Surikova, I. Neskubina, G. Zhukova, A. Shikhlyarova, M. Engibaryan, T. V. Ausheva, V. L. Volkova, M. Gusareva, P. Kachesova","doi":"10.18137/cardiometry.2023.27.5462","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.5462","url":null,"abstract":"Aims: to study the features of the functioning of the hypothalamic-pituitary-gonadal axis (HPGA) regulation in male rats at the stages of liver metastasizing. Materials and methods. Our research work was performed in 30 outbred male rats. Metastases in the liver were produced by implantation of sarcoma 45 (S45) cells into the spleen, which was previously positioned under the skin. The time spans of the study are 5 weeks (the pre-metastatic stage) and 7 weeks (the metastatic stage) after tumor cell transplantation. In the tissues, the content of the following hormones was determined by RIA: luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), total testosterone (Ttot), progesterone (P4); by ELISA we determined the content of the following hormones: gonadotropin-releasing hormone (GnRH), free testosterone (Tfr) and estrone (E1). Results. At all stages of the study, the level of GnRH in the hypothalamus decreased by more than 2.0 times; in the pituitary gland, the hormone levels had multidirectional dynamics: LH decreased by 1.6 times, and FSH increased by more than 6.0 times. Liver metastases were characterized by high levels of E1 and Ttot. In the gonads, a high level of P4 was recorded and concentrations of both forms of testosterone were reduced. The concentrations of E2 (by 1.6 times), Tfr (by 4.8 times) increased in blood, and the level of Ttot decreased (by 1.9 times). The salient features of HPGA in the presence of two metastasis sites (liver and lungs) were as follows: in blood, a 2.0 times lower increase in the LH and Tfr contents, a 1.6 times greater increase in E2, an increase in P4 (2.6 times), 1, 4 times lower level of FSH; in the gonads, there are found lower levels of P4, E1, but higher levels of Tfr and Ttot; in liver metastases, a greater increase in P4 (5.2 times), E1 (2.2 times) and Tfr (2.0 times) is recorded. Conclusion. Metastasizing to the liver was accompanied by activation of HPGA with the maximum accumulation of reactogenic E1 in liver metastases in rats with two metastasis sites that may indicate their more severe malignancy and ability to metastasize to the lungs.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48823509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.1219
O. Kit, V. Bandovkina, E. Frantsiyants, I. Kaplieva, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, L. K. Trepitaki, L. Nemashkalova, T. Moiseenko, A. Arakelova, M. Adamyan, N. Chernikova, Aina M. Salatova, Irina, V. Kaplieva, D. Natalia, Cheryarina, A. Lyudmila, Nemashkalova, L. Meri, Adamyan
Aims: to study the content of regulatory peptides in the hypothalamus and pituitary gland, as well as sex steroids in the gonads in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. Our experiment was performed in white outbred rats of both sexes with induced hypothyroidism, against the background of which Guerin’s carcinoma was transplanted. In 1% homogenates of the pituitary and the hypothalamus and in 10% homogenates of the gonads in the animals from the main and reference groups, the levels of GnRH (Casabio, China) were determined by the ELISA method using standard kits, and the content of LH, FSH, estradiol (E2), testosterone (T) and progesterone (P4) by the RIA method (Immunotech, Czech Republic). Statistical analysis of the results was performed using the Statistica 10.0 software package. Results. In females of the main group, the level of GnRH in the hypothalamus increased by 1.6 times, but the content of LH and FSH in the pituitary gland decreased, while in males the content of GnRH decreased by 1.4 times and FSH by 1.6 times compared with the intact animals. In the gonads of females of the main group, the content of E2 and T decreased by 1.3 times, but the level of P4 increased by 4.7 times, while in males the T production decreased by 7.1 times. Hypothyroidism, against the background of which Guerin’s carcinoma developed, had a significant effect both on the central links of the HPG axis and the peripheral ones, producing an additional hormonal imbalance in sex steroids
{"title":"Disorders in connections of the hypothalamic-pituitarygonadal axis in rats with Guerin’s carcinoma against the background of induced hypothyroidism","authors":"O. Kit, V. Bandovkina, E. Frantsiyants, I. Kaplieva, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, L. K. Trepitaki, L. Nemashkalova, T. Moiseenko, A. Arakelova, M. Adamyan, N. Chernikova, Aina M. Salatova, Irina, V. Kaplieva, D. Natalia, Cheryarina, A. Lyudmila, Nemashkalova, L. Meri, Adamyan","doi":"10.18137/cardiometry.2023.27.1219","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.1219","url":null,"abstract":"Aims: to study the content of regulatory peptides in the hypothalamus and pituitary gland, as well as sex steroids in the gonads in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. Our experiment was performed in white outbred rats of both sexes with induced hypothyroidism, against the background of which Guerin’s carcinoma was transplanted. In 1% homogenates of the pituitary and the hypothalamus and in 10% homogenates of the gonads in the animals from the main and reference groups, the levels of GnRH (Casabio, China) were determined by the ELISA method using standard kits, and the content of LH, FSH, estradiol (E2), testosterone (T) and progesterone (P4) by the RIA method (Immunotech, Czech Republic). Statistical analysis of the results was performed using the Statistica 10.0 software package. Results. In females of the main group, the level of GnRH in the hypothalamus increased by 1.6 times, but the content of LH and FSH in the pituitary gland decreased, while in males the content of GnRH decreased by 1.4 times and FSH by 1.6 times compared with the intact animals. In the gonads of females of the main group, the content of E2 and T decreased by 1.3 times, but the level of P4 increased by 4.7 times, while in males the T production decreased by 7.1 times. Hypothyroidism, against the background of which Guerin’s carcinoma developed, had a significant effect both on the central links of the HPG axis and the peripheral ones, producing an additional hormonal imbalance in sex steroids","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48940013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.118125
Ronay B. Sheker, Ruslan R. Nurgalin, Galina M. Yakovleva, Nataliya A. Zholobova, Frederika N. Nikonova, V. A. Kozhushkov, I. A. Kozhushkov, Nataliia E. Chebotar, Izobella A. Mussova, V. I. Bychkova, -. Natali, ya A. Zholobova
The paper analyzes the features of perioperative management of pediatric patients with congenital heart defects. The authors note that the perioperative period is the period starting from the moment of the beginning of the operation and ending with the moment of transfer of the patient to the ward after the operation. This period is very important for the recovery of children after surgery for a heart defect. In the perioperative period, indicators such as blood pressure, pulse, oxygen saturation, respiratory rate and other indicators are monitored to make sure that the patient is in a stable condition and there are no complications. In the perioperative period, measures are taken to prevent complications such as infections, bleeding, thrombosis, etc. Doctors also monitor the balanced administration of fluids and electrolytes to maintain the stability of the patient, and try to minimize the time of surgery to reduce stress for the patient and reduce the risk of complications. During the period under review, procedures are also carried out to support the postoperative period, such as the administration of medications and infusion solutions, maintaining body temperature and other procedures. In general, the perioperative period is of critical importance for the recovery of children after surgery for a heart defect. Proper monitoring of health indicators, prevention of complications, proper anesthesia and other procedures help children recover faster after surgery and reduce the risk of complications.
{"title":"FEATURES OF PERIOPERATIVE MANAGEMENT OF PEDIATRIC PATIENTS WITH CONGENITAL HEART DEFECTS","authors":"Ronay B. Sheker, Ruslan R. Nurgalin, Galina M. Yakovleva, Nataliya A. Zholobova, Frederika N. Nikonova, V. A. Kozhushkov, I. A. Kozhushkov, Nataliia E. Chebotar, Izobella A. Mussova, V. I. Bychkova, -. Natali, ya A. Zholobova","doi":"10.18137/cardiometry.2023.27.118125","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.118125","url":null,"abstract":"The paper analyzes the features of perioperative management of pediatric patients with congenital heart defects. The authors note that the perioperative period is the period starting from the moment of the beginning of the operation and ending with the moment of transfer of the patient to the ward after the operation. This period is very important for the recovery of children after surgery for a heart defect. In the perioperative period, indicators such as blood pressure, pulse, oxygen saturation, respiratory rate and other indicators are monitored to make sure that the patient is in a stable condition and there are no complications. In the perioperative period, measures are taken to prevent complications such as infections, bleeding, thrombosis, etc. Doctors also monitor the balanced administration of fluids and electrolytes to maintain the stability of the patient, and try to minimize the time of surgery to reduce stress for the patient and reduce the risk of complications. During the period under review, procedures are also carried out to support the postoperative period, such as the administration of medications and infusion solutions, maintaining body temperature and other procedures. In general, the perioperative period is of critical importance for the recovery of children after surgery for a heart defect. Proper monitoring of health indicators, prevention of complications, proper anesthesia and other procedures help children recover faster after surgery and reduce the risk of complications.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43429032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.2025
O. Kit, V. Bandovkina, E. Frantsiyants, I. Kaplieva, A. Shikhlyarova, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, L. K. Trepitaki, A. Arakelova, N. Maksimova, Yury A. Poryvaev, M. Ilchenko, V. Irina, Kaplieva, Irina V. Nesku, Lidia K. Trepit
The aim of our research work was to study the level of sex steroids in blood, the tumor and the perifocal zone in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. The experiment was performed in 110 outbred rats of both sexes. Hypothyroidism was induced in animals for 30 days with Mercazolil medication, and then Guerin’s carcinoma was transplanted (the main group). The reference groups included animals with an independent growth of Guerin’s carcinoma and with independent hypothyroidism, as well as intact animals (the norm). On the 18th day of the tumor growth, the animals were sacrificed, and, using standard RIA kits, in the serum, the tumor homogenates and the perifocal zone, the levels of estradiol (E2), testosterone (T) and progesterone (P4) were determined. Results. In comparison with intact animals, hypothyroidism caused an increase in the blood content of E2 in animals of both sexes by 2.2-2.4 times and T by 1.4-16 times, and P4 by 1.7 times only in females, but recorded was a decrease therein in males by 2.4 times. The growth of Guerin’s carcinoma resulted in a 2.5-5.5-fold decrease in E2 in blood of the animals of both sexes, an increase in T by 2.1 times and P4 by 3 times in the females, but a decrease in T by 2.6 times without changing P4 in the males. In the main group, in the animals of both sexes, similarly to the processes in hypothyroidism, the level of E2 and P4 increased by 1.4-1.6 times, and in females also T by 4.4 times, compared with the intact animals. Conclusion. Hypothyroidism and the growth of Guerin’s carcinoma changed E2 in different directions in animals of both sexes the level of sex hormones in blood and shifted the steroid balance in the tumor and its perifocal zone. In the females of the main group, the saturation of the tumor with estrogens, androgens and progesterone decreased, while in the males, on the contrary, the concentration of steroids increased.
{"title":"Influence by hypothyroidism on the level of sex hormones in blood and their intracrine content in the tumor in rats with Guerin’s carcinoma","authors":"O. Kit, V. Bandovkina, E. Frantsiyants, I. Kaplieva, A. Shikhlyarova, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, L. K. Trepitaki, A. Arakelova, N. Maksimova, Yury A. Poryvaev, M. Ilchenko, V. Irina, Kaplieva, Irina V. Nesku, Lidia K. Trepit","doi":"10.18137/cardiometry.2023.27.2025","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.2025","url":null,"abstract":"The aim of our research work was to study the level of sex steroids in blood, the tumor and the perifocal zone in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. The experiment was performed in 110 outbred rats of both sexes. Hypothyroidism was induced in animals for 30 days with Mercazolil medication, and then Guerin’s carcinoma was transplanted (the main group). The reference groups included animals with an independent growth of Guerin’s carcinoma and with independent hypothyroidism, as well as intact animals (the norm). On the 18th day of the tumor growth, the animals were sacrificed, and, using standard RIA kits, in the serum, the tumor homogenates and the perifocal zone, the levels of estradiol (E2), testosterone (T) and progesterone (P4) were determined. Results. In comparison with intact animals, hypothyroidism caused an increase in the blood content of E2 in animals of both sexes by 2.2-2.4 times and T by 1.4-16 times, and P4 by 1.7 times only in females, but recorded was a decrease therein in males by 2.4 times. The growth of Guerin’s carcinoma resulted in a 2.5-5.5-fold decrease in E2 in blood of the animals of both sexes, an increase in T by 2.1 times and P4 by 3 times in the females, but a decrease in T by 2.6 times without changing P4 in the males. In the main group, in the animals of both sexes, similarly to the processes in hypothyroidism, the level of E2 and P4 increased by 1.4-1.6 times, and in females also T by 4.4 times, compared with the intact animals. Conclusion. Hypothyroidism and the growth of Guerin’s carcinoma changed E2 in different directions in animals of both sexes the level of sex hormones in blood and shifted the steroid balance in the tumor and its perifocal zone. In the females of the main group, the saturation of the tumor with estrogens, androgens and progesterone decreased, while in the males, on the contrary, the concentration of steroids increased.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43422440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.3339
O. Kit, E. Frantsiyants, V. Bandovkina, I. Kaplieva, A. Shikhlyarova, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, L. K. Trepitaki, I. Kotieva, L. Vaschenko, Yulia Y. Kozel, A. S. Egorova, Irina, V. Kaplieva, V. Irina, Neskubina, K. Lidia, Trepitaki
The aim of our research work was to study changes in the level of hormones of the hypothalamus and pituitary gland in mice of both sexes in different variants of the B16/F10 melanoma growth. BALB/c Nude mice (n=84) of both sexes were divided into groups as follows: intact males and females (n=14); a reference group of mice of both sexes with standard subcutaneous B16/F10 melanoma inoculation (n=14); the main group of mice (n=14) where B16/F10 melanoma and Lewis carcinoma were inoculated into the mice sequentially subcutaneously on two sides: one on the left side, the other on the right side. At the terminal stage of the tumor growth, with ELISA using standard kits in 1% hypothalamic tissue homogenates we determined contents of releasing hormones as follows: corticotropic hormone (CRH), thyrotropic hormone (TRH), gonadotropic hormone (GnRH), somatotropic hormone (STH-R); in the pituitary with RIA determined were TSH, LH, FSH and ACTH (Immunotech, Czech Republic). Results. In males and females of both groups, the level of TRH in the hypothalamus decreased by 9-3.7 times, and only in females of the main group, the level of TSH in the pituitary gland increased by 2.8 times. Other releasing peptides in the hypothalamus of females increased by 1.9-6 times, while in males they decreased by 1.4-7 times. In the pituitary gland in males of both groups, the level of LH increased by 1.3-1.4 times and ACTH by 2.5-4 times, but FSH decreased by 7.8-13.6 times. In females, the level of FSH and ACTH in the pituitary gland decreased by 1.5 times – 1.8 times (р˂0.05), only in the main group the content of TSH increased by 2.8 times and only in the reference group LH by 1.6 times (р˂0.05). Conclusion. With the development of B16/F10 melanoma, there was a sex-dependent dysfunction of the hypothalamic-pituitary tract. Changes in the concentrations of GnRH, CRH, and STH-R in the hypothalamus in different directions in males and females indicate different mechanisms of hormonal imbalance in response to the growth of a malignant tumor.
{"title":"Features of changes in the content of hormones of the hypothalamic-pituitary tract depending on the independent or combined variant of B16/F10 melanoma growth in mice of both sexes","authors":"O. Kit, E. Frantsiyants, V. Bandovkina, I. Kaplieva, A. Shikhlyarova, E. Surikova, I. Neskubina, N. Cheryarina, Y. Pogorelova, L. K. Trepitaki, I. Kotieva, L. Vaschenko, Yulia Y. Kozel, A. S. Egorova, Irina, V. Kaplieva, V. Irina, Neskubina, K. Lidia, Trepitaki","doi":"10.18137/cardiometry.2023.27.3339","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.3339","url":null,"abstract":"The aim of our research work was to study changes in the level of hormones of the hypothalamus and pituitary gland in mice of both sexes in different variants of the B16/F10 melanoma growth. BALB/c Nude mice (n=84) of both sexes were divided into groups as follows: intact males and females (n=14); a reference group of mice of both sexes with standard subcutaneous B16/F10 melanoma inoculation (n=14); the main group of mice (n=14) where B16/F10 melanoma and Lewis carcinoma were inoculated into the mice sequentially subcutaneously on two sides: one on the left side, the other on the right side. At the terminal stage of the tumor growth, with ELISA using standard kits in 1% hypothalamic tissue homogenates we determined contents of releasing hormones as follows: corticotropic hormone (CRH), thyrotropic hormone (TRH), gonadotropic hormone (GnRH), somatotropic hormone (STH-R); in the pituitary with RIA determined were TSH, LH, FSH and ACTH (Immunotech, Czech Republic). Results. In males and females of both groups, the level of TRH in the hypothalamus decreased by 9-3.7 times, and only in females of the main group, the level of TSH in the pituitary gland increased by 2.8 times. Other releasing peptides in the hypothalamus of females increased by 1.9-6 times, while in males they decreased by 1.4-7 times. In the pituitary gland in males of both groups, the level of LH increased by 1.3-1.4 times and ACTH by 2.5-4 times, but FSH decreased by 7.8-13.6 times. In females, the level of FSH and ACTH in the pituitary gland decreased by 1.5 times – 1.8 times (р˂0.05), only in the main group the content of TSH increased by 2.8 times and only in the reference group LH by 1.6 times (р˂0.05). Conclusion. With the development of B16/F10 melanoma, there was a sex-dependent dysfunction of the hypothalamic-pituitary tract. Changes in the concentrations of GnRH, CRH, and STH-R in the hypothalamus in different directions in males and females indicate different mechanisms of hormonal imbalance in response to the growth of a malignant tumor.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43437638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-04DOI: 10.18137/cardiometry.2023.27.101110
I.S. Shipilov, A. Bakaev, A.Sh. Bobokhodzhiev, D.B. Kyagova, Robert Chotchaev, A. Muzafarova, I.U. Golubev, S.A. Pergunov
Modern medical diagnostics makes it possible to establish the presence of signs of a particular disease and enable specialists to prescribe a complex of therapeutic and medicinal measures to patients in a timely manner in accordance with the established diagnosis. However, in some cases, it is not always possible to diagnose a particular disease at an early stage due to the imperfection of diagnostic tools. In the recent period, the possibilities of artificial intelligence have been used in medical diagnostics, which significantly expands the capabilities of specialists in the field of establishing early key symptoms of the disease. However, the use of artificial intelligence capabilities in medical diagnostics is associated with a number of problems, the presence of which does not allow to realize the possibilities of digital technologies in full. The solution of these problems, according to the authors of the article, is highly relevant, since it can give a significant impetus to the development of diagnostic medical technologies, which will allow timely provision of high-quality medical care to patients.
{"title":"Problematic aspects of the use of artificial intelligence capabilities in modern medical diag-nostics","authors":"I.S. Shipilov, A. Bakaev, A.Sh. Bobokhodzhiev, D.B. Kyagova, Robert Chotchaev, A. Muzafarova, I.U. Golubev, S.A. Pergunov","doi":"10.18137/cardiometry.2023.27.101110","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.27.101110","url":null,"abstract":"Modern medical diagnostics makes it possible to establish the presence of signs of a particular disease and enable specialists to prescribe a complex of therapeutic and medicinal measures to patients in a timely manner in accordance with the established diagnosis. However, in some cases, it is not always possible to diagnose a particular disease at an early stage due to the imperfection of diagnostic tools. In the recent period, the possibilities of artificial intelligence have been used in medical diagnostics, which significantly expands the capabilities of specialists in the field of establishing early key symptoms of the disease. However, the use of artificial intelligence capabilities in medical diagnostics is associated with a number of problems, the presence of which does not allow to realize the possibilities of digital technologies in full. The solution of these problems, according to the authors of the article, is highly relevant, since it can give a significant impetus to the development of diagnostic medical technologies, which will allow timely provision of high-quality medical care to patients.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43525289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.18137/cardiometry.2023.26.857863
P. Prahlad, N. Vyas, N. Singh
Objective: This study aimed to measure preoperative stress in all patients undergoing cardiac surgery and to examine the relationship between preoperative stress and postoperative complications. Material and methods: The prospective study placed from Mar 2018-Dec 2019 at a single academic medical center. One hundred adults aged 18 to 65 who had undergone cardiac surgery consecutively were included in the analysis. The State Anxiety Inventory was used to quantify preoperative stress and assess its relationship to both postoperative pain and morphine usage. Result: The patient population is 67% men and 33% women, with an average age of 57 and 10 years. Before surgery, 66% of patients said they felt only a little bit of anxiety, while 34% said they were extremely anxious. Patients reporting moderate to severe anxiety (SA) before surgery had significantly higher mean pain ratings than patients reporting mild anxiety (MA). Patients who had moderate SA used much more morphine both during the procedure and thereafter than patients who did not experience stress. Conclusion: After cardiac surgery, patients that had moderate to severe stress before the procedure reported considerably greater levels of discomfort compared to that who had MA. Patients need greater analgesia postoperatively in addition to during surgery.
{"title":"The impact of preoperative stress on individuals' experience of postoperative complications after undergoing cardiac surgery","authors":"P. Prahlad, N. Vyas, N. Singh","doi":"10.18137/cardiometry.2023.26.857863","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.26.857863","url":null,"abstract":"Objective: This study aimed to measure preoperative stress in all patients undergoing cardiac surgery and to examine the relationship between preoperative stress and postoperative complications. Material and methods: The prospective study placed from Mar 2018-Dec 2019 at a single academic medical center. One hundred adults aged 18 to 65 who had undergone cardiac surgery consecutively were included in the analysis. The State Anxiety Inventory was used to quantify preoperative stress and assess its relationship to both postoperative pain and morphine usage. Result: The patient population is 67% men and 33% women, with an average age of 57 and 10 years. Before surgery, 66% of patients said they felt only a little bit of anxiety, while 34% said they were extremely anxious. Patients reporting moderate to severe anxiety (SA) before surgery had significantly higher mean pain ratings than patients reporting mild anxiety (MA). Patients who had moderate SA used much more morphine both during the procedure and thereafter than patients who did not experience stress. Conclusion: After cardiac surgery, patients that had moderate to severe stress before the procedure reported considerably greater levels of discomfort compared to that who had MA. Patients need greater analgesia postoperatively in addition to during surgery.","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48379076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.18137/cardiometry.2023.26.653657
C. Jegatha, V. Hemavathy
Diabetes claims the lives of about one million Indians each year. According to the Indian Heart Association, the number of people diagnosed with diabetes in India would rise the most by 2030. The increasing frequency is linked to a combination of genetic vulnerability and the growing middle class in India's adoption of a high-calorie, low-activity lifestyle. Pretest, patients had 7.88behaviour score and in posttest they had 12.00behaviour score, like a result, the average score difference is4.12, difference is huge and it is statistically significant behaviour gain score, The student's paired 't'test was used to determine statistical significance. The relationship between post-test behaviour and patient demographic characteristics. Above primary level educated patients and>10 years duration of illness patients are having more favorable behavior score than others. It was confirmed using chi square test and Yates corrected chi square test. This study concludes by proving the effectiveness of health education on behaviour on diabetic care among diabetic patients
{"title":"Effectiveness of health education on behaviour on diabetic care among rural adult diabetic patients -- a pilot analysis","authors":"C. Jegatha, V. Hemavathy","doi":"10.18137/cardiometry.2023.26.653657","DOIUrl":"https://doi.org/10.18137/cardiometry.2023.26.653657","url":null,"abstract":"Diabetes claims the lives of about one million Indians each year. According to the Indian Heart Association, the number of people diagnosed with diabetes in India would rise the most by 2030. The increasing frequency is linked to a combination of genetic vulnerability and the growing middle class in India's adoption of a high-calorie, low-activity lifestyle. Pretest, patients had 7.88behaviour score and in posttest they had 12.00behaviour score, like a result, the average score difference is4.12, difference is huge and it is statistically significant behaviour gain score, The student's paired 't'test was used to determine statistical significance. The relationship between post-test behaviour and patient demographic characteristics. Above primary level educated patients and>10 years duration of illness patients are having more favorable behavior score than others. It was confirmed using chi square test and Yates corrected chi square test. This study concludes by proving the effectiveness of health education on behaviour on diabetic care among diabetic patients","PeriodicalId":41726,"journal":{"name":"Cardiometry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49261673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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