Sensors and Actuators Reports最新文献

英文中文

Wearable sweat-sensing patches for non-invasive and continuous health tracking

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-11-27 DOI: 10.1016/j.snr.2024.100265

Suraj Shinde , Kang Hyeon Kim , Sang Yoon Park , Jeong Hyeon Kim , Jaechan Kim , Daniel J. Joe , Han Eol Lee

The demand for biosensing systems that accurately detect physiological signals and disease biomarkers while maintaining biocompatible surfaces drives ongoing research into advanced materials and novel designs. Wearable patch-based sensors have emerged as a promising solution for effective sweat management, offering easy induction, reliable collection, and precise analysis. This review systematically explores recent advancements in wearable sweat-sensing patches (WSPs) for personalized healthcare monitoring, highlighting their value in non-invasive and continuous health tracking. While recent reviews on wearable sweat sensing have provided general overviews of sweat sensing technologies, this review focuses on the integration of WSPs with emerging fields like flexible human-machine interfaces and smart healthcare solutions, addressing specific technical challenges and innovative approaches that distinguish current advancements. It provides a thorough analysis of key components, including structural materials, sensing mechanisms, innovative sweat collection techniques, and optimal attachment strategies. Additionally, the review addresses challenges and emerging trends, offering a pathway for integrating WSPs into flexible human-machine interfaces, personalized healthcare solutions, and closed-loop systems.

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引用次数: 0

Ion-selective electrode-based sensors from the macro- to the nanoscale 离子选择电极传感器从宏观到纳米尺度

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-11-22 DOI: 10.1016/j.snr.2024.100258

Yerim Kim , Minjee Seo , Seol Baek

Potentiometric ion-selective electrode (ISE) sensors are powerful electrochemical tools used in various applications in different fields, including the biological, clinical, and environmental fields, owing to their high selectivity, sensitivity, simplicity, and versatility. This review highlights recent advancements in ionophore-based polymeric ISE sensors over the past five years, with a particular focus on progress at the micro- and nanoscales. After discussing the conventional ISE configuration and its general operational principles, we explore the notable advancements in terms of the key ion-selective membrane components, such as ionophores, and other techniques combined with ISEs. These advancements have significantly improved the sensing performances and expanded the practical applications. We also examine the progress in the field of miniaturized solid-contact microelectrodes and the incorporation of novel functional materials for efficient ion-to-electron transduction. Miniaturized solid-state ISEs provide low limits of detection with reduced sample volume requirements, extended stability, and rapid response times. When combined with scanning electrochemical microscopy, ion-selective microelectrodes enable highly spatially resolved ion analyses. The integration of solid-contact ISEs into compact, portable, wearable devices has advanced the field of wearable on-body ISE sensors. Finally, we briefly introduce the development of ion-selective optode sensors as promising optical sensors based on ionophores that are particularly advantageous for cellular imaging.

电位离子选择电极（ISE）传感器是一种强大的电化学工具，由于其高选择性、灵敏度、简单性和多功能性，被广泛应用于生物、临床和环境等不同领域。本文综述了过去五年来基于离子载体的聚合物ISE传感器的最新进展，特别关注了微纳米尺度的进展。在讨论了传统的ISE配置及其一般操作原理之后，我们探讨了关键离子选择膜组分（如离子载体）和其他与ISE结合的技术方面的显着进展。这些进展大大提高了传感性能，扩大了实际应用范围。我们还研究了小型化固体接触微电极领域的进展，以及用于高效离子到电子转导的新型功能材料的结合。小型化固态ise提供低检测限，减少了样本量要求，延长了稳定性和快速响应时间。当与扫描电化学显微镜相结合时，离子选择性微电极可以进行高度空间分辨的离子分析。将固体接触式ISE集成到紧凑、便携、可穿戴设备中，推动了可穿戴式身体ISE传感器领域的发展。最后，我们简要介绍了离子选择性光电传感器的发展，离子选择性光电传感器是基于离子载体的光学传感器，对细胞成像特别有利。

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引用次数: 0

FRET-based reporter assesses lysosomal DNA-degradation ability in live cells 基于fret的报告评估活细胞中溶酶体dna降解能力

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-11-20 DOI: 10.1016/j.snr.2024.100259

Jared Morse, Ka Ho Leung

Lysosomes are multifunctional organelles that serve as the cell's central hub for metabolic signaling. Lysosomal malfunction disrupts intracellular homeostasis, leading to adverse health effects. Therefore, assessing lysosomal function is vital for advancing disease understanding and guiding therapeutic development. The existing evaluation methods rely primarily on monitoring lysosomal pH and protein degradation. Here we introduce a DNA-based reporter to evaluate lysosomal activity by assessing the DNA-degradation ability of lysosomes using fluorescence imaging. We successfully monitored the lysosomal DNA-degradation ability in dysregulated lysosomes and lysosomes in drug-induced disease model of NP-A/B and NP-C. We found that both pharmacologically induced models resulted in significant reduction in lysosomal DNA-degradation ability. This tool for monitoring lysosomal activity offers valuable insights for both therapeutic development and understanding disease progression.

溶酶体是一种多功能细胞器，是细胞代谢信号的中枢。溶酶体功能障碍破坏细胞内稳态，导致不良的健康影响。因此，评估溶酶体功能对于促进疾病的理解和指导治疗发展至关重要。现有的评估方法主要依赖于监测溶酶体pH值和蛋白质降解。在这里，我们引入了一种基于dna的报告器，通过荧光成像评估溶酶体的dna降解能力来评估溶酶体的活性。我们成功地监测了NP-A/B和NP-C药物性疾病模型中失调溶酶体和溶酶体的dna降解能力。我们发现两种药物诱导的模型都导致溶酶体dna降解能力显著降低。这种监测溶酶体活性的工具为治疗发展和了解疾病进展提供了有价值的见解。

引用次数: 0

Miniaturized power-integrated and self-powered sensor systems for advanced biomedical applications 用于先进生物医学应用的小型化电源集成和自供电传感器系统

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-11-19 DOI: 10.1016/j.snr.2024.100260

Jeongse Yun , Shanmuganathan Keerthana , Seung-Ryong Kwon

With the growing interest in continuous health monitoring and point-of-care diagnostics, researchers from various fields have made significant efforts to meet commercialization criteria. In this context, the role of electrochemistry and relevant technologies are noteworthy due to their versatility in both sensing and energy conversion applications. This review examines recent advancements in self-sufficient electrochemical sensors, with a particular focus on electrochemical energy conversion technologies such as fuel cells, photoelectrochemical cells, hydraulic systems, and iontronic power sources. It also highlights substantial progress in enhancing the practicality of electrochemical sensors for point-of-care diagnostics and wearable electronics. By introducing advanced wearable sensors and disposable devices, this review provides an overview of the integration of cutting-edge technologies in electrode design and fabrication, cell configuration, data readout, and signal transmission, along with meticulous design considerations to enhance usability.

随着人们对持续健康监测和即时诊断的兴趣日益浓厚，各个领域的研究人员为满足商业化标准做出了重大努力。在这种情况下，电化学和相关技术的作用是值得注意的，因为它们在传感和能量转换应用中的多功能性。本文综述了自给式电化学传感器的最新进展，特别关注了电化学能量转换技术，如燃料电池、光电电化学电池、液压系统和离子电子电源。它还强调了在提高用于即时诊断和可穿戴电子产品的电化学传感器的实用性方面取得的实质性进展。通过介绍先进的可穿戴传感器和一次性设备，本综述概述了电极设计和制造、电池配置、数据读出和信号传输方面的尖端技术的集成，以及精心设计以提高可用性的考虑。

引用次数: 0

Colorimetric detection and automatic quantitative analysis of mercury(II) ions via selective redox reaction sites on silver-coated gold nanorods 通过银涂层金纳米棒上的选择性氧化还原反应位点对汞（II）离子进行比色检测和自动定量分析

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-11-14 DOI: 10.1016/j.snr.2024.100256

Hayoung Kim , Sunghoon Yoo , Sumin Kim , Hyeon Seung Lee , Tae Jae Lee , Seunghyun Lee

Mercury (Hg), particularly Hg(II), poses significant environmental and health risks. Despite its known hazards, Hg²⁺ is widely used in various industries, thereby underscoring the need for simpler, faster, and more cost-effective methods for managing and monitoring Hg²⁺ emissions. In this study, we developed a colorimetric detection method for Hg²⁺ that leveraged the optical changes induced by the redox processes and amalgamation reactions between Au nanorod(NR)@Ag core-shell plasmonic nanoparticles and mercury ions. These nanoparticles were synthesized to exhibit distinct optical shifts by adjusting the Ag shell thickness. This enabled the visual detection of Hg²⁺ concentrations as low as 100 µM. In addition, changes in the optical spectrum of concentrations as low as 10 nM could be detected with UV–vis spectrometry. Furthermore, to account for individual differences in color perception, an automated analysis protocol was developed using ImageJ software for translating the color changes in smartphone-captured images of the solution into quantitative colorimetric data. This novel approach not only enabled the detection of mercury concentrations as low as 10 nM but also offered a simpler and more economical alternative to traditional methods. Furthermore, it demonstrated potential for implementation as on-site application to monitor mercury concentrations via rapid colorimetric reactions.

汞（Hg），尤其是 Hg(II)，对环境和健康构成重大风险。尽管 Hg2+ 的危害众所周知，但它仍被广泛应用于各行各业，因此需要更简单、更快速、更具成本效益的方法来管理和监测 Hg2+ 的排放。在本研究中，我们开发了一种 Hg2+ 的比色检测方法，该方法利用了金纳米棒（NR）@银核壳质子纳米粒子与汞离子之间的氧化还原过程和汞齐聚反应所引起的光学变化。通过调整银壳厚度，合成的这些纳米粒子表现出不同的光学偏移。这样就能对低至 100 µM 的 Hg2+ 浓度进行视觉检测。此外，低至 10 nM 的浓度的光谱变化也可通过紫外-可见光谱法检测到。此外，考虑到颜色感知方面的个体差异，还利用 ImageJ 软件开发了一套自动分析程序，用于将智能手机捕获的溶液图像中的颜色变化转化为定量比色数据。这种新方法不仅能检测低至 10 nM 的汞浓度，而且比传统方法更简单、更经济。此外，它还展示了通过快速比色反应监测汞浓度的现场应用潜力。

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引用次数: 0

A highly sensitive microfluidic biosensor for rapid and accurate detection of Salmonella in raw chicken products 用于快速准确检测生鸡肉产品中沙门氏菌的高灵敏度微流控生物传感器

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-11-08 DOI: 10.1016/j.snr.2024.100257

Mohammed Almalaysha , Arshdeep Singh , Sura A. Muhsin , Anna V. Carlson , Kate E. Trout , Amit Morey , Shuping Zhang , Lakshmikantha H. Channaiah , Mahmoud Almasri

This paper presents an investigation of a fluidic-based impedance biosensor for rapid and accurate detection of Salmonella Typhimurium in raw chicken carcass rinsate. The biosensor is engineered with multiple distinct regions that concentrates Salmonella antigens to a detectable level, subsequently trapping the concentrated Salmonella samples on top of the detection interdigitated electrode array coated with a specific Salmonella antibody, maximizing the number of captured antigens. Detection is achieved through the antibody-antigen binding process, where binding events changes impedance values, providing a reliable method for identifying and quantifying Salmonella. The biosensor demonstrated a low limit of detection (LOD) of 1–2 cells/ml within 40–50 min. The findings demonstrated that the biosensor distinguishes low concentrations of live Salmonella cells, even in the presence of high concentrations of dead Salmonella cells, and non-specific binding pathogens viz., Listeria monocytogenes and E. coli O157:H7.

本文研究了一种基于流体的阻抗生物传感器，用于快速准确地检测生鸡屠体冲洗液中的鼠伤寒沙门氏菌。该生物传感器设计了多个不同的区域，可将沙门氏菌抗原浓缩到可检测的水平，然后将浓缩的沙门氏菌样本捕获到涂有特异性沙门氏菌抗体的检测电极阵列上，从而最大限度地增加捕获抗原的数量。检测是通过抗体与抗原的结合过程实现的，结合事件会改变阻抗值，从而为识别和量化沙门氏菌提供了一种可靠的方法。该生物传感器的检测限（LOD）较低，40-50 分钟内可检测到 1-2 个细胞/毫升。研究结果表明，即使存在高浓度的沙门氏菌死细胞，该生物传感器也能区分低浓度的活沙门氏菌细胞和非特异性结合病原体，即李斯特菌和大肠杆菌 O157:H7。

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引用次数: 0

Enhancing nitrous oxide chemiresistive sensing performance by reducing ionic Oxygen species adsorption in Gold functionalized Tungsten Trioxide nanofibers 通过减少金功能化三氧化钨纳米纤维中的离子氧吸附，提高氧化亚氮化学电阻传感性能

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-11-04 DOI: 10.1016/j.snr.2024.100255

Dung Thi Hanh To, Bingxin Yang, Nosang Vincent Myung

Low-cost nitrous oxide (N₂O) gas sensor is in great need to provide real-time information to various stakeholders. Herein, various gold functionalized tungsten trioxide nanofibers (Au-WO₃ NFs) with different composition and crystallinity were synthesized by controlling electrospinning solutions and post heat treatment. These sensing materials were systematically exposed to various N₂O concentrations at different operating temperatures (i.e., 250 to 450 °C). Among different samples, 1 at % gold functionalized WO₃ nanofibers (1 at % Au-WO₃ NF) annealed at 600 °C for 24 h shows the highest sensitivity (S = R_a/R_o) of 38.5 toward 100 ppm at 250 °C with experimentally determined limit of detection (LOD) at 2.5 ppm. Although recovery and recovery time improved, the sensitivity reduced with an increase in operating temperatures. The detailed sensing mechanism studies indicated that the high N₂O sensing was achieved when there were limited adsorbed ionized oxygen species (e.g., O^-). Moreover, N₂O adsorption and desorption activation energy were estimated to be 0.13 and 0.87 eV where desorption was more strongly temperature dependent than adsorption.

低成本的一氧化二氮（N2O）气体传感器非常需要为各利益相关方提供实时信息。本文通过控制电纺丝溶液和后热处理合成了各种不同成分和结晶度的金功能化三氧化钨纳米纤维（Au-WO3 NFs）。这些传感材料在不同的工作温度（即 250 至 450 °C）下系统地暴露于不同浓度的一氧化二氮中。在不同的样品中，1% 的金功能化 WO3 纳米纤维（1% 的 Au-WO3 NF）在 600 °C 下退火 24 小时后显示出最高的灵敏度（S = Ra/Ro），在 250 °C 下对 100 ppm 的灵敏度为 38.5，实验确定的检测限（LOD）为 2.5 ppm。虽然回收率和回收时间有所提高，但灵敏度却随着工作温度的升高而降低。详细的传感机理研究表明，当吸附的电离氧物种（如 O-）有限时，就能实现对 N2O 的高度传感。此外，N2O 的吸附和解吸活化能估计分别为 0.13 和 0.87 eV，其中解吸比吸附更依赖于温度。

{"title":"Enhancing nitrous oxide chemiresistive sensing performance by reducing ionic Oxygen species adsorption in Gold functionalized Tungsten Trioxide nanofibers","authors":"Dung Thi Hanh To, Bingxin Yang, Nosang Vincent Myung","doi":"10.1016/j.snr.2024.100255","DOIUrl":"10.1016/j.snr.2024.100255","url":null,"abstract":"<div><div>Low-cost nitrous oxide (N<sub>2</sub>O) gas sensor is in great need to provide real-time information to various stakeholders. Herein, various gold functionalized tungsten trioxide nanofibers (Au-WO<sub>3</sub> NFs) with different composition and crystallinity were synthesized by controlling electrospinning solutions and post heat treatment. These sensing materials were systematically exposed to various N<sub>2</sub>O concentrations at different operating temperatures (<em>i.e.,</em> 250 to 450 °C). Among different samples, 1 at % gold functionalized WO<sub>3</sub> nanofibers (1 at % Au-WO<sub>3</sub> NF) annealed at 600 °C for 24 h shows the highest sensitivity (<em>S</em> = R<sub>a</sub>/R<sub>o</sub>) of 38.5 toward 100 ppm at 250 °C with experimentally determined limit of detection (LOD) at 2.5 ppm. Although recovery and recovery time improved, the sensitivity reduced with an increase in operating temperatures. The detailed sensing mechanism studies indicated that the high N<sub>2</sub>O sensing was achieved when there were limited adsorbed ionized oxygen species (<em>e.g.,</em> O<sup>-</sup>). Moreover, N<sub>2</sub>O adsorption and desorption activation energy were estimated to be 0.13 and 0.87 eV where desorption was more strongly temperature dependent than adsorption.</div></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":"8 ","pages":"Article 100255"},"PeriodicalIF":6.5,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical review of hydrogen cyanide (HCN) sensors and their applications 氰化氢 (HCN) 传感器及其应用评述

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-10-23 DOI: 10.1016/j.snr.2024.100254

Dung Thi Hanh To, Nosang V. Myung

Hydrogen cyanide (HCN) is a poison gas which can be generated from fuel combustion and conversion from aqueous CN^- ions. Approximately 1.1 million metric tons per year of cyanides are utilized by many industries. HCN is also an indicator of air quality, a biomarker for Pseudomonas aeruginosa infection, and a chemical warfare agent. Depending on applications, requirements for HCN sensors significantly vary. In this review, the past and current works on differents HCN gas detection techniques, including optical, mass-based, electrochemical, and chemiresistive sensors, are systematically reviewed. Additionally, it compares various parameters of sensing performance, such as detection range including lower and upper detection limit, sensitivity, selectivity, setup and operation complexity to help the potential users down select the proper type of sensors for their applications. Furthermore, materials computation to discover next generation HCN gas sensing materials is discussed.

氰化氢（HCN）是一种有毒气体，可由燃料燃烧和水性 CN- 离子转化产生。许多行业每年使用约 110 万公吨氰化物。HCN 还是空气质量指标、铜绿假单胞菌感染的生物标志物和化学战剂。根据应用的不同，对 HCN 传感器的要求也大相径庭。在这篇综述中，系统地回顾了过去和当前不同 HCN 气体检测技术的研究成果，包括光学传感器、质量传感器、电化学传感器和化学电阻传感器。此外，还比较了各种传感性能参数，如检测范围（包括检测下限和上限）、灵敏度、选择性、设置和操作复杂性，以帮助潜在用户选择适合其应用的传感器类型。此外，还讨论了通过材料计算发现下一代 HCN 气体传感材料的问题。

引用次数: 0

1D supramolecular assembly-induced emission and colorimetry toward precise onsite mercury(II) detection 一维超分子组装诱导发射和比色法实现现场汞（II）的精确检测

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-10-18 DOI: 10.1016/j.snr.2024.100253

Duan Xiong , Zhen Su , Lixin Zhang , Hao Zhang , Zhiwei Su , Xiaoyun Hu , Mailidan Wumaer , Qingqing Guan

Manipulation of the one-dimensional (1D) supramolecular assembly of platinum(II) terpyridyl complex is promising for achieving precise onsite mercury(II) detection in complex environments, but still challenging. Herein, by systematic molecular design of platinum(II) terpyridyl complex, chloride-mediated 1D supramolecular assembly has been successfully achieved, exhibiting not only improved recognition ability but also dual-visual signal, with turn-on red luminescence and high-contrast color change from pale-yellow to orange-red. The probe also shows excellent selectivity and anti-interference properties, fast response rate (< 1 s) and low detection limit, stretching to 20.6 fg when incorporated in a hydrogel matrix. Structure insight for the dual-visual response shows that this high detection performance derives from the ancillary ligand of -NCS, which endows the increase of ion-association ability between platinum(II) terpyridyl complex and [HgCl₄]²⁻, leading that 1D packing mode with strengthened Pt-Pt interactions. In all, this work highlights a new strategy of 1D supramolecular assembly construction for high performance detection of heavy metal ions.

操纵铂(II)三吡啶络合物的一维(1D)超分子组装有望在复杂环境中实现现场汞(II)的精确检测，但仍具有挑战性。本文通过对铂(II)萜吡啶络合物进行系统的分子设计，成功实现了以氯化物为介导的一维超分子组装，不仅提高了识别能力，还表现出双重视觉信号，即红色发光和从淡黄色到橙红色的高对比度颜色变化。该探针还具有出色的选择性和抗干扰性，响应速度快（1 秒），检测限低，加入水凝胶基质后可达到 20.6 fg。对双视觉响应结构的深入研究表明，这种高检测性能源于 -NCS 的辅助配体，它增强了铂(II)三吡啶络合物与[HgCl4]2-之间的离子结合能力，导致铂铂相互作用增强的一维堆积模式。总之，这项工作强调了一种用于高性能重金属离子检测的 1D 超分子组装构建新策略。

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引用次数: 0

Rapid detection of human adenovirus by multiple cross displacement amplification combined with nanoparticle-based biosensor platform 通过多重交叉置换扩增结合纳米粒子生物传感器平台快速检测人类腺病毒

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2024-10-16 DOI: 10.1016/j.snr.2024.100252

Linglong Wan , Xiaolan Huang , Jin Fu , Fei Xiao , Nan Jia , Yu Zhang , Min Chen , Xiong Zhu , Shijun Li , Juan Zhou , Yi Wang

Human adenoviruses (HAdV), particularly serotypes 3 and 7 (HAdV-3 and HAdV-7), are significant respiratory pathogens that contribute to high morbidity rates and severe pneumonia in infants and children. The lack of distinct clinical presentations and effective treatments highlights the urgent need for rapid and reliable diagnostic methods for HAdV-3 and HAdV-7. This study devises a novel detection assay, termed HAdV-MCDA-LFB, which combines isothermal multiple cross displacement amplification (MCDA) with a nanoparticle-based lateral flow biosensor (LFB). Targeting the conserved hexon gene, HAdV-MCDA-LFB demonstrated high sensitivity, detecting low to 10 fg of hexon-containing plasmid per reaction without cross-reaction under the optimized conditions. Moreover, HAdV-MCDA-LFB exhibited comparable diagnostic accuracy to real-time PCR in clinical sample analysis, indicating its practical applicability. The whole procedure, including rapid template preparation (15 min), MCDA reaction (40 min at 67 °C) and result interpretation (<5 min), can be completed within one hour. Together, this rapid turnaround time, coupled with its simplicity and accuracy, makes HAdV-MCDA-LFB a promising point-of-care diagnostic tool for HAdV-3 and HAdV-7, particularly in resource-limited settings.

人类腺病毒（HAdV），尤其是血清型 3 和 7（HAdV-3 和 HAdV-7），是导致婴幼儿高发病率和严重肺炎的重要呼吸道病原体。由于缺乏独特的临床表现和有效的治疗方法，因此迫切需要快速可靠的 HAdV-3 和 HAdV-7 诊断方法。本研究设计了一种新型检测方法，称为 HAdV-MCDA-LFB，它将等温多重交叉位移扩增（MCDA）与基于纳米粒子的侧流生物传感器（LFB）相结合。针对保守的 hexon 基因，HAdV-MCDA-LFB 表现出极高的灵敏度，在优化条件下，每次反应可检测低至 10 fg 的含 hexon 质粒，且无交叉反应。此外，在临床样本分析中，HAdV-MCDA-LFB 的诊断准确性可与实时 PCR 相媲美，这表明它具有实用性。整个过程包括快速模板制备（15 分钟）、MCDA 反应（40 分钟，67 ℃）和结果判读（5 分钟），可在一小时内完成。这种快速的周转时间，再加上其简便性和准确性，使 HAdV-MCDA-LFB 成为一种很有前途的 HAdV-3 和 HAdV-7 床旁诊断工具，尤其是在资源有限的环境中。

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引用次数: 0

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