Sensors and Actuators Reports最新文献_第7页

A novel impedimetric biosensor based on titanium nitride nano-electrode arrays for influenza A H1N1 testing 基于氮化钛纳米电极阵列的新型抗阻生物传感器用于甲型H1N1流感检测

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-09-14 DOI: 10.1016/j.snr.2025.100384

Yi-Chen Li , Shu-Tsai Cheng , Chun-Lung Lien , Jeng-Huei Shiau , Ching-Fen Shen , Chao-Min Cheng

The development of point-of-care testing devices for real-time detection of influenza A H1N1 virus is critical for early diagnosis, and for continuous disease monitoring. In this study, we developed a novel impedimetric biosensor for detecting influenza A H1N1 virus, using a nano-electrode array fabricated through standard complementary metal-oxide-semiconductor technology. Each nano-electrode is a raised structure with a radius of 100 nanometers and a height of 200 nanometers. Titanium nitride was chosen as the electrode material for its biocompatibility and compatibility with semiconductor processes. The electrode surfaces were modified by diazonium electrografting to introduce carboxyl groups, which enabled antibody immobilization via carbodiimide coupling chemistry. We analyzed the relationship between the reduction peak current and the percentage change in charge transfer resistance before and after each modification step, and further examined the correlation between changes during modification and antibody binding. The completed biosensor successfully detected influenza A H1N1 antigens in phosphate-buffered saline, achieving a detection limit of 0.00025 EU/mL. The sensor’s response also showed a strong positive correlation with viral RNA content (Pearson r = 0.9702), indicating its potential for quantitative virus detection. These results demonstrate the feasibility of using semiconductor-based nano-electrode array biosensors for point-of-care infectious disease diagnostics.

开发实时检测甲型H1N1流感病毒的即时护理检测设备对于早期诊断和持续疾病监测至关重要。在这项研究中，我们开发了一种新型的阻抗生物传感器，用于检测甲型H1N1流感病毒，该传感器使用了通过标准互补金属氧化物半导体技术制造的纳米电极阵列。每个纳米电极是一个半径为100纳米，高度为200纳米的凸起结构。选择氮化钛作为电极材料是因为其具有生物相容性和与半导体工艺的相容性。电极表面通过重氮电接枝修饰引入羧基，从而通过碳二亚胺偶联化学实现抗体的固定化。我们分析了每个修饰步骤前后的还原峰电流与电荷转移电阻百分比变化的关系，并进一步检验了修饰过程中的变化与抗体结合的相关性。完成的生物传感器成功检测了磷酸盐缓冲盐水中的甲型H1N1流感抗原，检测限为0.00025 EU/mL。该传感器的响应也与病毒RNA含量呈强正相关（Pearson r = 0.9702），表明其具有定量检测病毒的潜力。这些结果证明了使用半导体纳米电极阵列生物传感器进行即时传染病诊断的可行性。

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引用次数: 0

Smart flexible wearables for non-invasive body fluid monitoring: a multidisciplinary roadmap and future directions 用于无创体液监测的智能柔性可穿戴设备：多学科路线图和未来方向

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-28 DOI: 10.1016/j.snr.2025.100380

Yizhou Bai , Chaojing Li , Fujun Wang , Lu Wang , Jiaxue Zhu , Guoping Guan

Real-time monitoring and understanding of individual health status not only enable the prompt identification of potential health concerns, thereby facilitating timely interventions to prevent severe injury or mortality, but also assist individuals in managing their lifestyles effectively, improving health behaviors, and enhancing overall quality of life. The paradigm shift toward non-invasive health monitoring through smart flexible wearables represents a transformative convergence of multidisciplinary innovation. Advancements in textile science, materials science, biomedicine, computer science, and electronic information and communication technology have resulted in the continuous emergence of flexible, comfortable, sensitive, and precise smart wearable monitoring devices. The range of monitoring indicators has expanded beyond traditional metrics, such as body temperature, blood pressure, and heart rate, to encompass a range of biomarkers and biomolecules found in bodily fluids. Furthermore, the targets for monitoring have broadened from blood to encompass sweat, interstitial fluid, saliva, tears, and exhaled breath, marking a transition from invasive to non-invasive methodologies. Therefore, to inspire the continuous enhancement and evolution of smart wearable products and foster the development of innovations, this review summarizes existing advancements, identifying critical challenges, and offering perspectives on future innovations, this study aims to serve as a multidisciplinary roadmap for the development of next-generation wearable technologies. This review aims to provide a multidisciplinary roadmap for the development of next-generation wearable technologies, highlighting key materials and application contexts associated with these technologies. Finally, this review outlines the challenges faced by this technology and presents perspectives on future advancements.

实时监测和了解个人健康状况，不仅可以及时发现潜在的健康问题，从而促进及时干预，防止严重伤害或死亡，而且还可以帮助个人有效地管理自己的生活方式，改善健康行为，提高整体生活质量。通过智能灵活的可穿戴设备向无创健康监测的范式转变代表了多学科创新的变革性融合。纺织科学、材料科学、生物医学、计算机科学、电子信息与通信技术的进步，使得灵活、舒适、灵敏、精确的智能可穿戴监测设备不断涌现。监测指标的范围已经超出了体温、血压和心率等传统指标，涵盖了体液中的一系列生物标志物和生物分子。此外，监测目标已从血液扩大到汗液、间质液、唾液、眼泪和呼出的气体，标志着从侵入性方法向非侵入性方法的过渡。因此，为了激发智能可穿戴产品的不断增强和发展，促进创新的发展，本综述总结了现有的进展，确定了关键挑战，并提供了未来创新的观点，本研究旨在为下一代可穿戴技术的发展提供多学科路线图。本综述旨在为下一代可穿戴技术的发展提供多学科路线图，重点介绍与这些技术相关的关键材料和应用环境。最后，本文概述了该技术面临的挑战，并对未来的发展提出了展望。

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引用次数: 0

MXene/Graphene Nanoribbons Composite Materials for High-Sensitivity Enzyme-Free Electrochemiluminescent Detection of L-Lactic acid MXene/石墨烯纳米带复合材料高灵敏度无酶电化学发光检测l -乳酸

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-24 DOI: 10.1016/j.snr.2025.100379

Haicheng Song , Xiaoqian Zhou , Lixing Lin , Xinying Zhang , Yingying Chen , Zhenzhen Li , Lingyan Feng

Lactic acid level is a crucial biochemical indicator in the field of cancer diagnosis, anti-tumor therapy and other related biomedical areas. However, currently the method for detecting lactic acid is almost enzyme-based biosensors, while enzyme-free alternatives remain underexplored. In this work, we constructed a high-performance electrochemiluminescence (ECL) sensors based on Ti₃C₂ MXene/graphene nanoribbons (MXene/GNRs) composite for the enzyme-free detection of L-lactic acid. Meanwhile, we functionalize MXene/GNRs composite with the L-lactic acid aptamer through physical and chemical interactions, and with the addition of the target L-Lactic acid, the aptamer was detached from the surface of the material, thus, the biosensor was constructed with an "on-off-on" ECL signal. The biosensor designed for this work demonstrated a detection range of L-Lactic acid from 500 nM to 10 mM, and a low detection limit of 309 nM. This work exhibits superior detection performance in complex environments, and also presents a promising enzyme-free approach for L-lactic acid monitoring in biomedical applications.

乳酸水平是肿瘤诊断、抗肿瘤治疗等相关生物医学领域的重要生化指标。然而，目前检测乳酸的方法几乎是基于酶的生物传感器，而无酶的替代品仍未得到充分的探索。在这项工作中，我们构建了一种基于Ti3C2 MXene/石墨烯纳米带（MXene/GNRs）复合材料的高性能电化学发光（ECL）传感器，用于无酶检测l -乳酸。同时，我们通过l -乳酸适配体与MXene/GNRs复合材料的物理化学相互作用实现功能化，随着目标l -乳酸的加入，适配体从材料表面分离，从而构建了具有“on-off-on”ECL信号的生物传感器。该传感器对l -乳酸的检测范围为500 nM ~ 10 mM，最低检测限为309 nM。这项工作在复杂环境中表现出优越的检测性能，也为生物医学应用中的l -乳酸监测提供了一种有前途的无酶方法。

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引用次数: 0

Silkworm gut fibre-based biosensors for optical glucose detection 用于光学葡萄糖检测的蚕肠纤维生物传感器

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-23 DOI: 10.1016/j.snr.2025.100378

Aina Fitó-Parera , Augusto Márquez , Pablo Rodríguez-Núñez , Salvador D. Aznar-Cervantes , Ana Cristina Reguera , Francisco Perdigones , Carmen Aracil , Rosalía Rodríguez-Rodríguez , Carlos Domínguez , Xavier Muñoz-Berbel

Silk is a re-emerging biomaterial with significant potential for optical waveguiding due to its high transparency in the visible spectrum and elevated refractive index. Naturally occurring silk filamentous structures, such as silkworm gut fibres (SGFs), resemble traditional optical fibres while offering advantages such as biocompatibility, flexibility, mechanical strength and biodegradability. In this study, SGFs from different Bombyx mori races were evaluated for their suitability in optical fibre-based biosensing applications. White SGFs were selected for their superior optical properties, including a broad transmission window in the visible spectrum, strong light confinement, and high guidance efficiency. However, pristine SGFs exhibited sensitivity to hydration/drying cycles, leading to transmission losses. To address this, an alginate cladding was applied, stabilizing the fibre while preserving biocompatibility and optical performance. The modified SGFs successfully quantified colorants in the surrounding medium and were further employed in biochemical sensing. Specifically, alginate-coated SGFs enabled glucose detection by monitoring the colorimetric response of a redox mediator oxidized through a bi-enzymatic reaction involving glucose oxidase and peroxidase. This system effectively distinguished glucose concentrations corresponding to healthy, hypoglycaemic, and hyperglycaemic (pre-diabetic and diabetic) conditions. Furthermore, direct glucose measurements in real blood samples were possible, as the alginate layer functioned as a size-exclusion filter, selectively retaining cellular components while allowing glucose to diffuse and react with immobilized enzymes and redox mediators. The use of silk and alginate, both recognised as biodegradable materials, suggests significant potential for the development of real-time, minimally invasive glucose monitoring systems for in vitro and in vivo analysis.

丝是一种新兴的生物材料，由于其在可见光谱中的高透明度和高折射率，具有重要的光波导潜力。天然存在的丝状结构，如蚕肠纤维（SGFs），类似于传统的光纤，同时具有生物相容性、柔韧性、机械强度和生物降解性等优点。在这项研究中，我们对不同家蚕品种的sgf在基于光纤的生物传感应用中的适用性进行了评估。选择白色SGFs是因为其优越的光学特性，包括在可见光谱中具有宽的透射窗口，强光约束和高制导效率。然而，原始SGFs对水化/干燥循环表现出敏感性，导致传输损失。为了解决这个问题，应用了海藻酸盐包层，在保持生物相容性和光学性能的同时稳定了纤维。改进的SGFs成功地定量了周围介质中的着色剂，并进一步应用于生化传感。具体来说，海藻酸盐包被的SGFs通过监测氧化还原介质通过涉及葡萄糖氧化酶和过氧化物酶的双酶反应氧化的比色反应来实现葡萄糖检测。该系统有效地区分了健康、低血糖和高血糖（糖尿病前期和糖尿病）状态下的葡萄糖浓度。此外，在真实血液样本中直接测量葡萄糖是可能的，因为海藻酸盐层作为尺寸排除过滤器，选择性地保留细胞成分，同时允许葡萄糖扩散并与固定化酶和氧化还原介质发生反应。蚕丝和海藻酸盐都被认为是可生物降解的材料，它们的使用表明，用于体外和体内分析的实时、微创血糖监测系统的开发具有巨大的潜力。

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引用次数: 0

Electrochemical sensor for the detection of imidacloprid using novel Cu-tetrazole MOF 新型cu -四唑MOF电化学传感器检测吡虫啉

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-23 DOI: 10.1016/j.snr.2025.100377

Joseph Joe Habr , Fatima El Alem , Pandiaraj Kanagavalli , Upendar Reddy Gandra , Anish Mathai Varghese , Hassan Saraierh , Ibrahim Yildiz , Ayalew H. Assen , Gareth Price , Shimaa Eissa , M․ Infas H․ Mohideen

Designing sensitive and rapid sensing platforms for detecting pesticide residues is crucial for ensuring environmental and food safety. In this work, we report the synthesis of a novel Cu-Tetrazole Metal-Organic Framework referred to as KU-1 and its utilization for the development of an electrochemical sensor for the detection of imidacloprid (IMD) residues in food samples. The MOF structure consists of Cu ions and tetrazole ligands that extend to form 2D layers, which are further pillared by tetrazoles to create a 3D network. The KU-1 exhibits high stability, retaining crystallinity in various organic solvents and a range of pH, with thermal stability up to ∼300°C. The electrochemical sensing of IMD at KU-1 modified screen-printed electrode was investigated in detail, demonstrating the material's high electrocatalytic performance. The developed sensor allowed imidacloprid detection in the linear range of 0.1–10 μM with a detection limit of 0.089 μM and showed excellent selectivity for IMD against other pesticides. Detection of IMD residues was successfully validated in rice and tomato sample extracts and had a remarkable recovery of 97–101%, showcasing the electrode's practicality and reliability. This study highlights the potential of KU-1 as a promising material for constructing high-performance electrochemical sensors.

设计灵敏、快速的农药残留检测平台对于确保环境和食品安全至关重要。在这项工作中，我们报道了一种新的Cu-Tetrazole金属有机框架（KU-1）的合成，并将其用于开发用于检测食品样品中吡虫啉（IMD）残留的电化学传感器。MOF结构由Cu离子和延伸形成二维层的四唑配体组成，四唑配体进一步支撑形成三维网络。KU-1表现出高稳定性，在各种有机溶剂和pH范围内保持结晶度，热稳定性高达~ 300°C。详细研究了KU-1改性丝网印刷电极对IMD的电化学传感，证明了该材料具有良好的电催化性能。该传感器在0.1 ~ 10 μM的线性范围内检测吡虫啉，检出限为0.089 μM，对其他农药具有良好的选择性。稻谷和番茄提取液中IMD残留量的检测效果良好，回收率为97 ~ 101%，显示了该电极的实用性和可靠性。该研究突出了KU-1作为构建高性能电化学传感器的有前途的材料的潜力。

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引用次数: 0

Straightforward and sensitive detection of micro-nano plastics with surface-enhanced Raman spectroscopy by the filtration-dissolution- adsorption strategy 采用过滤-溶解-吸附策略的表面增强拉曼光谱对微纳塑料进行简单、灵敏的检测

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-21 DOI: 10.1016/j.snr.2025.100376

Hao Liu , Hui Liang , Siyuan Zheng , Rui Hu , Wenqiang Pei , Le Wang , Yongchao Lai

Micro-nano plastics (MNPs) have become pervasive throughout the environment and emerged as significant pollutants, posing a potential threat to the natural environment and human health. Nonetheless, there remains a technological gap in the accurate analysis of trace and small-size MNPs in the environment. This study proposes a refined strategy for sample pretreatment and surface-enhanced Raman spectroscopy (SERS) analysis of MNPs in a water environment. MNPs were initially captured from the matrix using filter membranes, and subsequently released using an appropriate solvent. This approach not only separated the MNPs from the matrix and impurities, but also allowed the irregular and rigid MNPs to fit the surface of the KI-modified SERS substrates. This SERS-based approach facilitates the analysis of polystyrene (PS) MNPs of varying sizes at a concentration of 0.05 ng/mL across multiple water matrices. Furthermore, PS MNPs released from disposable cups were found using this method in everyday life. This simple and highly efficient strategy is ideal for the analyzing MNPs in everyday life and has the potential to facilitate future research on MNPs in the environment and their impact on human health.

微纳塑料在环境中无处不在，已成为重要的污染物，对自然环境和人类健康构成潜在威胁。尽管如此，在准确分析环境中痕量和小尺寸MNPs方面仍然存在技术差距。本研究提出了一种用于水环境中MNPs样品预处理和表面增强拉曼光谱（SERS）分析的改进策略。MNPs最初使用过滤膜从基质中捕获，随后使用适当的溶剂释放。这种方法不仅使MNPs与基体和杂质分离，而且使不规则和刚性的MNPs能够贴合ki修饰的SERS底物的表面。这种基于sers的方法有助于分析不同大小的聚苯乙烯（PS） MNPs，浓度为0.05 ng/mL，跨越多种水基质。此外，在日常生活中，用这种方法发现了一次性杯子释放的PS MNPs。这种简单而高效的策略是分析日常生活中MNPs的理想方法，并有可能促进未来对环境中MNPs及其对人类健康影响的研究。

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引用次数: 0

Molecularly imprinted poly(o-aminophenol)-based electrochemical sensor for the quantitative detection of a VP28 biomarker for white spot syndrome virus 基于分子印迹聚邻氨基酚的电化学传感器定量检测白斑综合征病毒VP28生物标志物

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-17 DOI: 10.1016/j.snr.2025.100375

Young-Ran Yun , Hyoung Jun Kim , Sung Yang

White spot syndrome virus (WSSV) is a deadly pathogen that can cause mass mortality within several days. VP28, known as a biomarker of WSSV, accounts for over half of the total envelope protein. It plays a crucial role in viral infection and is a useful diagnostic indicator for immunological detection.

Here, we developed a molecularly imprinted polymer (MIP)-based electrochemical sensor using a gold nanostructured electrode and assessed its performance in detecting VP28. The electropolymerized poly(o-aminophenol) film supplies specific binding sites complementary to VP28. The molecularly imprinted cavities were examined using electrochemical analysis to confirm their ability to recognize the target molecule. The sensor generates a response signal through label-free sensing with a redox probe. It demonstrated a detection limit of 7.01 ng/mL (S/N = 3) and an imprinting factor of 4.25 at 0.78–50 ng/mL concentrations. The selectivity study revealed a response signal 4.5 times higher for the target molecule than for interfering substances. Compared with the standard PCR method for real samples, the MIP-based sensor performed similarly according to virus concentration. These findings suggested that the MIP-based sensor is a simple and suitable alternative to conventional WSSV detection methods. This electrochemical sensing platform with electropolymerization of the molecularly imprinted polymer can promote the detection and monitoring of WSSV expressing VP28.

白斑综合征病毒（WSSV）是一种致命的病原体，可在几天内造成大量死亡。VP28是WSSV的生物标志物，占总包膜蛋白的一半以上。它在病毒感染中起着至关重要的作用，是一种有用的免疫检测诊断指标。在此，我们利用金纳米结构电极开发了一种基于分子印迹聚合物（MIP）的电化学传感器，并评估了其检测VP28的性能。电聚合的聚邻氨基酚薄膜提供了与VP28互补的特定结合位点。利用电化学分析对分子印迹空腔进行了检测，以确认其识别靶分子的能力。该传感器通过氧化还原探针的无标签传感产生响应信号。在0.78 ~ 50 ng/mL浓度下，检测限为7.01 ng/mL (S/N = 3)，印迹因子为4.25。选择性研究表明，靶分子的响应信号是干扰物质的4.5倍。与真实样品的标准PCR方法相比，基于mip的传感器根据病毒浓度的表现相似。这些发现表明，基于mip的传感器是传统WSSV检测方法的一种简单而合适的替代方法。该电化学传感平台利用分子印迹聚合物的电聚合，可促进表达VP28的WSSV的检测和监测。

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引用次数: 0

Electromagnetically induced transparent terahertz dual-split-ring metamaterial for ultra-high sensitivity sensor applications 用于超高灵敏度传感器的电磁诱导透明太赫兹双分裂环超材料

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-14 DOI: 10.1016/j.snr.2025.100374

Yunche Zhu, Daoye Zheng, Yu-Sheng Lin

We present three dual-split-ring metamaterial (DSRM) devices with electromagnetic induced transparency (EIT) characteristics and simulated the optical parameters of the device. They are composed of outer split-ring resonators (SRRs) with different rotation angles of 0°, 45°, and 90°, named as DSRM-1, DSRM-2, and DSRM-3 respectively. By changing the height of the outer SRR from 0.5 μm to 4.0 μm, the EIT resonances of DSRM devices can be modulated. The EIT windows of DRSM-1 and DSRM-2 can be tuned 0.4 THz and 0.3 THz, respectively. Meanwhile, both DSRM-1 and DSRM-2 are ultra-highly sensitive to the change of ambient refractive index. The maximum sensitivity is 638 GHz/RIU. Moreover, DSRM-3 shows stable to the change of background refractive index. The EIT resonant intensity of DSRM-3 can be modulated gradually by increasing the height of the outer SRR. These results indicate that DSRM devices possess potential applications in the reconfigurable filters, optical switches, programmable logic operators, highly sensitive sensors in the THz-wave optoeelctronics fields.

提出了三种具有电磁感应透明（EIT）特性的双分裂环超材料（DSRM）器件，并对器件的光学参数进行了仿真。它们由旋转角度为0°、45°和90°的外裂环谐振器（srr）组成，分别命名为DSRM-1、DSRM-2和DSRM-3。通过改变外SRR的高度从0.5 μm到4.0 μm，可以调制DSRM器件的EIT共振。DRSM-1和DSRM-2的EIT窗口可以分别调谐到0.4 THz和0.3 THz。同时，DSRM-1和DSRM-2对环境折射率的变化都具有超高的敏感性。最大灵敏度为638 GHz/RIU。此外，DSRM-3对背景折射率的变化表现出稳定的特性。通过增加外SRR的高度，可以逐渐调制DSRM-3的EIT谐振强度。这些结果表明，DSRM器件在太赫兹光电子领域的可重构滤波器、光开关、可编程逻辑运算器、高灵敏度传感器等方面具有潜在的应用前景。

引用次数: 0

Highly efficient and toxicologically safe ZnO(NP)@GO nanocomposite in the simultaneous detection of Cd²⁺, Hg²⁺, Pb²⁺, and Zn²⁺ in aqueous medium 高效、毒理学安全的ZnO(NP)@GO纳米复合材料在水介质中同时检测Cd 2 +、Hg 2 +、Pb 2 +和Zn 2 +

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-11 DOI: 10.1016/j.snr.2025.100373

Melody Lalhruaitluangi , Lalruatkima Ralte , Diwakar Tiwari , Jinho Jung

Miniaturised devices for trace, simultaneous and off-site detection are the need of the hour for protecting public health and the environment at large. Using sustainable and greener approach, the current study explores using Acmella oleracea extract to derive zinc oxide nanoparticles. Further, ZnO incorporates graphene oxide to obtain the nanocomposite material (ZnO(NP)@GO). The thin film electrode using the ZnO(NP)@GO efficiently detects potential heavy metal ions viz., Cd²⁺, Hg²⁺, Pb²⁺, and Zn²⁺ individually and simultaneously at trace level concentrations. The thin film electrode using the ZnO(NP)@GO showed significantly enhanced electroactive surface area and reduced electron transfer resistance compared to the unmodified glassy carbon electrode. The calibration curve for detecting Cd²⁺, Hg²⁺, Pb²⁺, and Zn²⁺ shows the limits of detection of 0.026, 0.03, 0.010 and 0.020 µgL⁻¹, respectively, in their simultaneous detection. The ZnO(NP)@GO thin film electrode possesses good shelf life and stability for repeated detections of these heavy metal toxic ions. Furthermore, the thin film electrode detects simultaneously these ions at trace levels in the hospital effluent waters with real implications. Moreover, the acute toxicity of ZnO(NP)@GO towards D. magna shows an EC₅₀ value of 115.7 mgL⁻¹ after 48 hrs, proving the safety and environmental sustainability of the modified electrode.

用于痕量、同时和非现场检测的小型化设备是保护公众健康和整个环境的时代需要。利用可持续和更环保的方法，目前的研究探索了使用马鞭草提取物来获得氧化锌纳米颗粒。此外，ZnO与氧化石墨烯结合得到纳米复合材料（ZnO(NP)@GO）。使用ZnO(NP)@GO的薄膜电极有效地检测潜在的重金属离子，即Cd 2 +、Hg 2 +、Pb 2 +和Zn 2 +分别在痕量浓度下同时检测。与未修饰的玻碳电极相比，ZnO(NP)@GO薄膜电极的电活性表面积显著增加，电子转移电阻显著降低。Cd 2 +、Hg 2 +、Pb 2 +和Zn 2 +同时检测的检出限分别为0.026、0.03、0.010和0.020µgL⁻¹。ZnO(NP)@GO薄膜电极具有良好的保质期和稳定性，可用于重复检测这些重金属有毒离子。此外，薄膜电极同时检测这些离子在痕量水平的医院污水具有实际意义。此外，ZnO(NP)@GO对D. magna的急性毒性在48小时后的EC50值为115.7 mg - 1，证明了修饰电极的安全性和环境可持续性。

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引用次数: 0

Acid-resistant PVP/gold nanoparticles cluster for gastric juice-based metabolomics analysis 耐酸PVP/金纳米粒子簇用于胃液代谢组学分析

IF 7.6 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports

Pub Date : 2025-08-09 DOI: 10.1016/j.snr.2025.100370

Taeyeon Kim , Minsu Jang , Yeongjun Jeon , Seungwook Han , You Hwan Kim , Sunwoo Park , Hyeyun Lee , Woosok Moon , Tae-Young Jeong , Cheol Woong Choi , Jin-Woo Oh

This study aims to develop a surface-enhanced Raman scattering (SERS)-based technology capable of directly analyzing metabolites in gastric juice using acid-resistant nanostructure for the diagnosis of gastric cancer. Although gastric cancer has a high incidence and mortality rate, existing endoscopic examination methods have limitations such as low sensitivity and operator dependency. In this study, we fabricated nanoparticles (NPs) cluster structure using Au NPs encapsulated in polyvinylpyrrolidone (PVP) to maintain structural stability even in strongly acidic environments. The PVP-Au NPs solution mixed with gastric juice was coated using the meniscus guided deposition technique to fabricate a uniform NPs cluster, thereby ensuring high chemical stability and reproducibility of SERS signals. The acquired SERS spectra were preprocessed and transformed into barcode-format features, which were then used to train a neural-network-based machine learning classification model. In the analysis of 121 gastric juice samples, the model accurately classified gastric cancer with a sensitivity of 91.7 % and a specificity of 91.7 % in the test set. This study demonstrates the potential of a high-precision gastric cancer diagnostic platform that integrates an acid-resistant PVP-based Au NPs cluster structure with machine learning classification and suggests its possible expansion as an auxiliary diagnostic tool for screening high-risk groups and predicting future prognosis.

本研究旨在开发一种基于表面增强拉曼散射（SERS）的技术，利用耐酸纳米结构直接分析胃液中的代谢物，用于胃癌的诊断。虽然胃癌的发病率和死亡率很高，但现有的内镜检查方法存在敏感性低、对操作者的依赖性等局限性。在本研究中，我们将金纳米粒子包裹在聚乙烯吡咯烷酮（PVP）中，制备出纳米粒子簇状结构，即使在强酸性环境中也能保持结构的稳定性。将与胃液混合的PVP-Au NPs溶液采用半月板引导沉积技术包被，形成均匀的NPs簇，从而保证了高化学稳定性和SERS信号的再现性。对采集到的SERS光谱进行预处理并转化为条形码格式的特征，然后用于训练基于神经网络的机器学习分类模型。在对121份胃液样本的分析中，该模型对胃癌的准确分类，灵敏度为91.7%，特异性为91.7%。本研究证明了将基于耐酸vpp的Au NPs聚类结构与机器学习分类相结合的高精度胃癌诊断平台的潜力，并表明其可能扩展为筛查高危人群和预测未来预后的辅助诊断工具。

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