{"title":"Inadequate Amyloid Clearance in Alzheimer's Disease: The Possible Role of TTR Transporter Protein and LRP-1 Receptor","authors":"","doi":"10.12996/gmj.2023.23","DOIUrl":"https://doi.org/10.12996/gmj.2023.23","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44457954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Depression at Health Schools","authors":"","doi":"10.12996/gmj.2023.7","DOIUrl":"https://doi.org/10.12996/gmj.2023.7","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44671295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"“Universal Tumor” for a Reason, Uncommon Lipoma over Thumb","authors":"","doi":"10.12996/gmj.2023.19","DOIUrl":"https://doi.org/10.12996/gmj.2023.19","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45315392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Karaciger Fibrozisinde Sinyal Yolaklari","authors":"","doi":"10.12996/gmj.2023.24","DOIUrl":"https://doi.org/10.12996/gmj.2023.24","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49546993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between Postoperative Neutrophil/Lymphocyte Ratio, Neutrophil/Platelet Ratio with Mortality after Off-Pump Cardiac Surgery in Premature Newborns","authors":"","doi":"10.12996/gmj.2023.9","DOIUrl":"https://doi.org/10.12996/gmj.2023.9","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42432004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasma Ghrelin Levels to Predict Severity of Pulmonary Arterial Hypertension Ghrelin in Relation to Pulmonary Hypertension","authors":"","doi":"10.12996/gmj.2023.13","DOIUrl":"https://doi.org/10.12996/gmj.2023.13","url":null,"abstract":"","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47863918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kronik Obstrüktif Akciğer Hastalığı Alevlenmesinde Tiroid Disfonksiyonu, S. Bahçeci̇oğlu, E. Koç, T. Akkale, M. Yalçın, N. Köktürk
Introduction: Chronic obstructive pulmonary disease (copd) is a devastating lung disease which could be related with systemic consequences. Chronic comorbidities either develop independently or in association with systemic manifestation could lead increase morbidity or mortality in copd. thyroid gland dysfunctions are also a comorbidity that can accompany copd patients. This study was undertaken to study to show the distribution of thyroid hormone dysfunction in the setting of exacerbation in patients with Copd. Methods: A group of 105 hospitalized copd patients were included to this cross-sectional study to evaluate the thyroid hormone dysfunction in the setting of exacerbation in patients with Copd. Results: We Included 105 patients to the study,but 26 individuals were excluded due to the effect of steroid use on thyroid functions and one for sick euthyroid syndrome with low t4 serum levels.the patients were stratified into 2 subsets according to tsh concentrations:sick euthyroid syndrome and normal euthyroid function.32% of patients had normal euthyroid function,68% of them were sick euthyroid syndrome.We observed significant decrease of both po 2 and pco 2 in sick euthyroid syndrome patients(po 2 : 53.35mmhg±10.55 vs. and 61.24mmhg±12.36 patients with normal thyroid function;p=0,022; pco 2 : 39.35mmhg±8.08 vs. and 47,88mmhg±13.96 patients with normal thyroid function; P=0,017). Conclusion: We found low pO 2 and pCO 2 in patients with NTIS compared to patients with normal thyroid function.This results are some similarities with the arterial blood gas values of patients with hypothyroidism.pO 2 was low in both hypothyroidism and NTIS .But we found lower pCO 2 which was different from hypothyroid COPD patients.Lowering pCO 2 can be the compansation of the body from hypoxic conditions.
{"title":"Thyroid Dysfunction in Exacerbation of Chronic Obstructive Pulmonary Disease","authors":"Kronik Obstrüktif Akciğer Hastalığı Alevlenmesinde Tiroid Disfonksiyonu, S. Bahçeci̇oğlu, E. Koç, T. Akkale, M. Yalçın, N. Köktürk","doi":"10.12996/gmj.2023.4","DOIUrl":"https://doi.org/10.12996/gmj.2023.4","url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease (copd) is a devastating lung disease which could be related with systemic consequences. Chronic comorbidities either develop independently or in association with systemic manifestation could lead increase morbidity or mortality in copd. thyroid gland dysfunctions are also a comorbidity that can accompany copd patients. This study was undertaken to study to show the distribution of thyroid hormone dysfunction in the setting of exacerbation in patients with Copd. Methods: A group of 105 hospitalized copd patients were included to this cross-sectional study to evaluate the thyroid hormone dysfunction in the setting of exacerbation in patients with Copd. Results: We Included 105 patients to the study,but 26 individuals were excluded due to the effect of steroid use on thyroid functions and one for sick euthyroid syndrome with low t4 serum levels.the patients were stratified into 2 subsets according to tsh concentrations:sick euthyroid syndrome and normal euthyroid function.32% of patients had normal euthyroid function,68% of them were sick euthyroid syndrome.We observed significant decrease of both po 2 and pco 2 in sick euthyroid syndrome patients(po 2 : 53.35mmhg±10.55 vs. and 61.24mmhg±12.36 patients with normal thyroid function;p=0,022; pco 2 : 39.35mmhg±8.08 vs. and 47,88mmhg±13.96 patients with normal thyroid function; P=0,017). Conclusion: We found low pO 2 and pCO 2 in patients with NTIS compared to patients with normal thyroid function.This results are some similarities with the arterial blood gas values of patients with hypothyroidism.pO 2 was low in both hypothyroidism and NTIS .But we found lower pCO 2 which was different from hypothyroid COPD patients.Lowering pCO 2 can be the compansation of the body from hypoxic conditions.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46346625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdul Hadi Anuar, Mohd Nizam Md Hashim, Z. Zakaria, Wan Zainira Wan Zain, S. Aziz, Siti Rahmah, H. Merican, Rosnelifaizur Ramely, Wan Mokhzani Wan Mokhter, I. S. Mohamad, F. Hayati, Nik Amin, Sahid Nik Lah, A. Zakaria
Introduction: Improvement of surgical outcomes in emergency laparotomy surgery remained dubious. Physiology and Operative Severity Score for the enumeration of Mortality (POSSUM) and Portsmouth-POSSUM (P-POSSUM) have been validated in multiple studies. The objective of this study is to determine the value of both as surgical audit tool predicting the morbidity and mortality of emergency laparotomy in a single tertiary centre in Malaysia. Methods: A retrospective review was performed in Hospital Universiti Sains Malaysia after obtaining ethical approval. All adult subjects that underwent emergency abdominal surgery from 2012 until 2015 were reviewed. Data collected were subjects' demography, clinical-pathological profiles and clinical pathway characteristics. Expected morbidity and mortality were calculated using POSSUMs risk prediction model and subsequently compared against the observed outcome. The risk prediction model was analyzed using Hosmer and Lemeshow Goodness of Fit statistical test. Results: Eighty-three (83) subjects were analyzed in this study. The proportion of 30-day in-hospital morbidity was 44 (53.0%) subjects and in-hospital mortality was 12 (14.5%) subjects. Eighteen subjects that developed in-hospital morbidity had suffered a respiratory complication. The observed-to-expected ratio of POSSUM predicting morbidity was 0.9 and P-POSSUM predicting morbidity was 0.8. However, using Hosmer and Lemershow Goodness of Fit statistical analysis, the p-value of less than 0.05 showed both POSSUM and P-POSSUM predicted poor morbidity and mortality across all risk stratifications in this population. Conclusions: POSSUM and P-POSSUM are not suitable for surgical audit tool in this centre because both produce a poor prediction of in-hospital morbidity and mortality in emergency laparotomy.
引言：在急诊剖腹手术中，手术结果的改善仍然令人怀疑。死亡率计数的生理学和手术严重程度评分（POSSUM）和朴茨茅斯POSSUM（P-POSSUM）已在多项研究中得到验证。本研究的目的是确定两者作为预测马来西亚一个三级中心急诊剖腹手术发病率和死亡率的手术审计工具的价值。方法：在获得伦理批准后，在马来西亚Sains大学医院进行回顾性审查。回顾了2012年至2015年期间接受紧急腹部手术的所有成年受试者。收集的数据包括受试者的人口学、临床病理学特征和临床路径特征。使用POSSUM风险预测模型计算预期发病率和死亡率，并随后与观察结果进行比较。使用Hosmer和Lemeshow拟合良好度统计检验对风险预测模型进行分析。结果：本研究对83名受试者进行了分析。30天住院发病率为44例（53.0%），住院死亡率为12例（14.5%）。18名在医院发病的受试者出现了呼吸道并发症。POSSUM预测发病率的观察与预期比率为0.9，P-POSSUM预计发病率为0.8。然而，使用Hosmer和Lemershow Goodness of Fit统计分析，小于0.05的p值表明，POSSUM和p-POSSUM在该人群的所有风险分层中预测的发病率和死亡率都很低。结论：POSSUM和P-POSSUM不适合作为该中心的手术审计工具，因为它们对急诊剖腹手术的住院发病率和死亡率的预测都很差。
{"title":"The Value of POSSUM & P-POSSUM as Surgical Audit Tool Predicting Morbidity and Mortality in Emergency Laparotomy","authors":"Abdul Hadi Anuar, Mohd Nizam Md Hashim, Z. Zakaria, Wan Zainira Wan Zain, S. Aziz, Siti Rahmah, H. Merican, Rosnelifaizur Ramely, Wan Mokhzani Wan Mokhter, I. S. Mohamad, F. Hayati, Nik Amin, Sahid Nik Lah, A. Zakaria","doi":"10.12996/gmj.2023.3","DOIUrl":"https://doi.org/10.12996/gmj.2023.3","url":null,"abstract":"Introduction: Improvement of surgical outcomes in emergency laparotomy surgery remained dubious. Physiology and Operative Severity Score for the enumeration of Mortality (POSSUM) and Portsmouth-POSSUM (P-POSSUM) have been validated in multiple studies. The objective of this study is to determine the value of both as surgical audit tool predicting the morbidity and mortality of emergency laparotomy in a single tertiary centre in Malaysia. Methods: A retrospective review was performed in Hospital Universiti Sains Malaysia after obtaining ethical approval. All adult subjects that underwent emergency abdominal surgery from 2012 until 2015 were reviewed. Data collected were subjects' demography, clinical-pathological profiles and clinical pathway characteristics. Expected morbidity and mortality were calculated using POSSUMs risk prediction model and subsequently compared against the observed outcome. The risk prediction model was analyzed using Hosmer and Lemeshow Goodness of Fit statistical test. Results: Eighty-three (83) subjects were analyzed in this study. The proportion of 30-day in-hospital morbidity was 44 (53.0%) subjects and in-hospital mortality was 12 (14.5%) subjects. Eighteen subjects that developed in-hospital morbidity had suffered a respiratory complication. The observed-to-expected ratio of POSSUM predicting morbidity was 0.9 and P-POSSUM predicting morbidity was 0.8. However, using Hosmer and Lemershow Goodness of Fit statistical analysis, the p-value of less than 0.05 showed both POSSUM and P-POSSUM predicted poor morbidity and mortality across all risk stratifications in this population. Conclusions: POSSUM and P-POSSUM are not suitable for surgical audit tool in this centre because both produce a poor prediction of in-hospital morbidity and mortality in emergency laparotomy.","PeriodicalId":42791,"journal":{"name":"Gazi Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49276330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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