Pub Date : 2018-01-01DOI: 10.25179/tjem.20182202-p098
B. E. Bilir, B. Bilir
Objective: Osteoporosis is a common metabolic bone disease. All women over the age of 65, all men over the age of 70 and the younger cases having some other risk factors are recommended to be screened for osteoporosis. In this study, we tried to show how much of the cases that were recommended to be screened had already been evaluated by DEXA. Methods: The age, height, weight and osteoporosis risk factors data of 125 cases, who admitted to our endocrinology out-patient clinics between October 2017 and February 2018 and must already been screened, were recorded. The cases were questioned whether their bone mineral density was assessed with DEXA previously. Fracture risk situations were analyzed by means of Fracture Risk Assessment Tool (FRAX) adapted for Turkey. The mean calculated risk of hip and major osteoporotic fractures and the frequency of each risk factor were assessed using the SPSS-21 statistical software program. Results: A total of 125 cases (106 female and 19 male) aged between 47 and 85 were evaluated with a mean age of 68. The means of weight and height were 76.08 kg and 155.2 cm respectively, 92% of the patients were non-smokers and any of the cases did not use alcohol regularly. Four cases were on glucocorticoid treatment and six cases were diagnosed with rheumatoid arthritis, 59.2% of cases had a secondary cause (8 cases were on aromatase inhibitor therapy for breast cancer, 1 had hypoparathyroidism, 4 had primary hyperparathyroidism, 15 had premature ovarian failure, 14 cases were thyrotoxic that 5 of them were iatrogenic thyrotoxicosis because of differentiated thyroid carcinoma treatment). While there was a personal history of fractures in 27.2% of cases, the parental fracture history was present in 8% of cases. While the mean 10-year-major osteoporotic fracture risk calculated by the FRAX scoring system was 6.05% (2.5-49), the mean risk of hip fracture was 1.6% (0.2-40). The percentage of those evaluated with DEXA previously despite the current indication for osteoporosis screening was only 55.5%. According to the FRAX calculation system, 24.8% of our cases were in high risk group for fracture, but only 48.4% of these cases were evaluated with DEXA. Conclusion: In our outpatient clinics, we neglect evaluating the risk of fracture which has so severe economical and emotional burden after it develops.
目的:骨质疏松症是一种常见的代谢性骨病。所有65岁以上的女性，70岁以上的男性以及有其他危险因素的年轻人都应该接受骨质疏松筛查。在这项研究中，我们试图表明有多少被推荐进行筛查的病例已经被DEXA评估过。方法:记录2017年10月至2018年2月我院内分泌科门诊收治的经筛查的125例患者的年龄、身高、体重及骨质疏松症危险因素数据。研究人员询问这些病例之前是否用DEXA评估过骨密度。采用适用于土耳其的FRAX压裂风险评估工具(FRAX)分析压裂风险情况。使用SPSS-21统计软件评估髋部和主要骨质疏松性骨折的平均计算风险以及各危险因素的发生频率。结果:共125例(女106例，男19例)，年龄47 ~ 85岁，平均年龄68岁。体重和身高平均值分别为76.08 kg和155.2 cm, 92%的患者不吸烟，所有病例均不经常饮酒。糖皮质激素治疗4例，类风湿关节炎6例，继发病因占59.2%(乳腺癌芳香化酶抑制剂治疗8例，甲状旁腺功能减退1例，原发性甲状旁腺功能亢进4例，卵巢早衰15例，甲状腺毒性14例，其中5例因分化性甲状腺癌治疗导致的医疗源性甲状腺毒性)。27.2%的病例有个人骨折史，8%的病例有父母骨折史。FRAX评分系统计算的10年主要骨质疏松性骨折平均风险为6.05%(2.5-49)，髋部骨折平均风险为1.6%(0.2-40)。尽管目前有骨质疏松症筛查的适应症，但先前接受DEXA评估的患者比例仅为55.5%。根据FRAX计算系统，24.8%的病例属于骨折高危组，但其中只有48.4%的病例进行了DEXA评估。结论:骨折发生后给患者带来了严重的经济和情感负担，在门诊治疗中忽视了对骨折风险的评估。
{"title":"Do We Neglect the Risk of Fracture","authors":"B. E. Bilir, B. Bilir","doi":"10.25179/tjem.20182202-p098","DOIUrl":"https://doi.org/10.25179/tjem.20182202-p098","url":null,"abstract":"Objective: Osteoporosis is a common metabolic bone disease. All women over the age of 65, all men over the age of 70 and the younger cases having some other risk factors are recommended to be screened for osteoporosis. In this study, we tried to show how much of the cases that were recommended to be screened had already been evaluated by DEXA. Methods: The age, height, weight and osteoporosis risk factors data of 125 cases, who admitted to our endocrinology out-patient clinics between October 2017 and February 2018 and must already been screened, were recorded. The cases were questioned whether their bone mineral density was assessed with DEXA previously. Fracture risk situations were analyzed by means of Fracture Risk Assessment Tool (FRAX) adapted for Turkey. The mean calculated risk of hip and major osteoporotic fractures and the frequency of each risk factor were assessed using the SPSS-21 statistical software program. Results: A total of 125 cases (106 female and 19 male) aged between 47 and 85 were evaluated with a mean age of 68. The means of weight and height were 76.08 kg and 155.2 cm respectively, 92% of the patients were non-smokers and any of the cases did not use alcohol regularly. Four cases were on glucocorticoid treatment and six cases were diagnosed with rheumatoid arthritis, 59.2% of cases had a secondary cause (8 cases were on aromatase inhibitor therapy for breast cancer, 1 had hypoparathyroidism, 4 had primary hyperparathyroidism, 15 had premature ovarian failure, 14 cases were thyrotoxic that 5 of them were iatrogenic thyrotoxicosis because of differentiated thyroid carcinoma treatment). While there was a personal history of fractures in 27.2% of cases, the parental fracture history was present in 8% of cases. While the mean 10-year-major osteoporotic fracture risk calculated by the FRAX scoring system was 6.05% (2.5-49), the mean risk of hip fracture was 1.6% (0.2-40). The percentage of those evaluated with DEXA previously despite the current indication for osteoporosis screening was only 55.5%. According to the FRAX calculation system, 24.8% of our cases were in high risk group for fracture, but only 48.4% of these cases were evaluated with DEXA. Conclusion: In our outpatient clinics, we neglect evaluating the risk of fracture which has so severe economical and emotional burden after it develops.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"1 1","pages":"44-44"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75650103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.20182202-P188
Ş. Akın, S. Akın, O. Kupik
{"title":"Vandetanib Experience in a Patient with Ectopic Cushing Syndrome in Metastatic Medullary Thyroid Cancer","authors":"Ş. Akın, S. Akın, O. Kupik","doi":"10.25179/TJEM.20182202-P188","DOIUrl":"https://doi.org/10.25179/TJEM.20182202-P188","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"63 3 1","pages":"66-66"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77585701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.2018-61752
H. Nimmanapalli, Pullaiah Pasupuleti, Suresh Vakkakara, S. Pvln
{"title":"A Study of Nontraditional Biochemical Markers and Their Relation to the Level of Fasting Glycemia in Patients with Type 2 Diabetes Mellitus","authors":"H. Nimmanapalli, Pullaiah Pasupuleti, Suresh Vakkakara, S. Pvln","doi":"10.25179/TJEM.2018-61752","DOIUrl":"https://doi.org/10.25179/TJEM.2018-61752","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"56 1","pages":"225-230"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84527985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.20182202-P89
M. Keskin, A. Koca, M. Dağdeviren, D. Ertuğrul, M. Altay
{"title":"Case Report: The Efficacy of Zolendronic Acid in Patients with Osteogenesis Imperfecta","authors":"M. Keskin, A. Koca, M. Dağdeviren, D. Ertuğrul, M. Altay","doi":"10.25179/TJEM.20182202-P89","DOIUrl":"https://doi.org/10.25179/TJEM.20182202-P89","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"49 1","pages":"43-43"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72894632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.20182202-P128
R. Uçler, G. Sönmez, S. Yıldız
{"title":"Simultaneous Papillary and Medullary Carcinoma in the Thyroid Gland","authors":"R. Uçler, G. Sönmez, S. Yıldız","doi":"10.25179/TJEM.20182202-P128","DOIUrl":"https://doi.org/10.25179/TJEM.20182202-P128","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"37 1","pages":"52-52"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76010497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.2018-59710
M. Ashrafi, Zahra Afsar, H. Erjaee, S. Nazifi
{"title":"The Effects of Saffron (Crocus sativus) Aqueous Extract on TNF-α Levels in Liver, Kidney, and Lens Tissues of Diabetic Rats","authors":"M. Ashrafi, Zahra Afsar, H. Erjaee, S. Nazifi","doi":"10.25179/TJEM.2018-59710","DOIUrl":"https://doi.org/10.25179/TJEM.2018-59710","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"136 1","pages":"217-224"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86402319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/tjem.2017-56533
S. Bahsi, A. Uzay, Nigar Rustemova, F. Onder, O. Celik
{"title":"Successful Preoperative Treatment with Plasmapheresis of Patients with Hyperthyroidism","authors":"S. Bahsi, A. Uzay, Nigar Rustemova, F. Onder, O. Celik","doi":"10.25179/tjem.2017-56533","DOIUrl":"https://doi.org/10.25179/tjem.2017-56533","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"13 1","pages":"0-0"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88828238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.20182202-S31
Özlem Haliloğlu, Merve Nur Alçiçek, F. Çetinkaya, S. Şahin, Ozge Polat Korkmaz, S. Uğurlu, P. Kadıoğlu
Aim: To evaluate joint complaints, physical examinations and X-rays of acromegalic patients and investigate association between arthropathy and disease remission and effects of arthropathy on quality of life. Method: Acromegalic patients followed at Endocrinology clinic of Cerrahpasa Medical Faculty between 2015-2017 were screened. Demographic and disease status, physical examinations and quality of life scales (Acro-QoL) were recorded. The symptoms and examination findings of patients consulted with Rheumatology or Physical Therapy-Rehabilitation departments and X-rays were evaluated, retrospectively. Results: Ninety-seven patients were assessed, 38 patients (F/M:31/7; p=0.006) had joint complaints and 59 (60.8%; F/M: 40/19; p>0.05) had pathological joint findings. Pathological joint signs were found in 30 patients with no symptoms, whereas 9 out of 38 patients who declared joint symptoms had no signs at rheumatological examination. Patients with symptoms and signs were older (47.6±11.5 vs 53.3±11.9; p=0.02 and 44.3±9.1 vs 53.4±12.3; p<0.001, respectively). When patients were evaluated according to remission status as remission with medical treatment (n=43), remission after surgery(n=27) and active disease (n=18); duration of disease in active disease group was shorter (p=0.01). Other parameters were similar between groups. There was a significant correlation between AcroQoL and shoulder and AcroQoL and small hand joints involvements (p=0.007, r=-0.2 vs p=0.004, r=-0.3), whereas no correlation was found between AcroQoL and knee or elbow involvements. No association found between disease duration and symptoms, examination findings, radiological findings or AcroQoL. Conclusion: Joint degenerative changes detected in 60% of acromegalic patients, and affect quality of life, Regular evaluation of joint symptoms is recommended in the management of acromegalic patients. S-31
目的:评价肢端肥大症患者的关节主诉、体格检查和x线检查，探讨关节病变与疾病缓解的关系以及关节病变对生活质量的影响。方法:对2015-2017年在Cerrahpasa医学院内分泌科门诊随访的肢端肥大症患者进行筛查。记录人口统计学和疾病状况、体格检查和生活质量量表(Acro-QoL)。对就诊于风湿病科或物理治疗康复科的患者的症状和检查结果进行回顾性评估。结果:共纳入97例患者，38例(F/M:31/7;P =0.006)， 59例(60.8%;F / M: 40/19;P >0.05)均有关节病理表现。在30例无症状的患者中发现病理性关节体征，而38例有关节症状的患者中有9例在风湿病学检查中无症状。出现症状和体征的患者年龄较大(47.6±11.5 vs 53.3±11.9;P =0.02和44.3±9.1 vs 53.4±12.3;分别为p < 0.001)。将患者的缓解状态分为药物治疗缓解(n=43)、手术后缓解(n=27)和活动性疾病缓解(n=18);活动性疾病组病程较短(p=0.01)。各组间其他参数相似。AcroQoL与肩关节、小手关节受累有显著相关性(p=0.007, r=-0.2 vs p=0.004, r=-0.3)，而与膝关节或肘关节受累无相关性。疾病持续时间与症状、检查结果、放射学结果或AcroQoL之间无关联。结论:60%的肢端肥大症患者存在关节退行性改变，并影响生活质量，建议在肢端肥大症患者的治疗中定期评估关节症状。S-31
{"title":"Joint Involvement in Patients with Acromegaly and the Association Between Arthropathy and Disease Remission","authors":"Özlem Haliloğlu, Merve Nur Alçiçek, F. Çetinkaya, S. Şahin, Ozge Polat Korkmaz, S. Uğurlu, P. Kadıoğlu","doi":"10.25179/TJEM.20182202-S31","DOIUrl":"https://doi.org/10.25179/TJEM.20182202-S31","url":null,"abstract":"Aim: To evaluate joint complaints, physical examinations and X-rays of acromegalic patients and investigate association between arthropathy and disease remission and effects of arthropathy on quality of life. Method: Acromegalic patients followed at Endocrinology clinic of Cerrahpasa Medical Faculty between 2015-2017 were screened. Demographic and disease status, physical examinations and quality of life scales (Acro-QoL) were recorded. The symptoms and examination findings of patients consulted with Rheumatology or Physical Therapy-Rehabilitation departments and X-rays were evaluated, retrospectively. Results: Ninety-seven patients were assessed, 38 patients (F/M:31/7; p=0.006) had joint complaints and 59 (60.8%; F/M: 40/19; p>0.05) had pathological joint findings. Pathological joint signs were found in 30 patients with no symptoms, whereas 9 out of 38 patients who declared joint symptoms had no signs at rheumatological examination. Patients with symptoms and signs were older (47.6±11.5 vs 53.3±11.9; p=0.02 and 44.3±9.1 vs 53.4±12.3; p<0.001, respectively). When patients were evaluated according to remission status as remission with medical treatment (n=43), remission after surgery(n=27) and active disease (n=18); duration of disease in active disease group was shorter (p=0.01). Other parameters were similar between groups. There was a significant correlation between AcroQoL and shoulder and AcroQoL and small hand joints involvements (p=0.007, r=-0.2 vs p=0.004, r=-0.3), whereas no correlation was found between AcroQoL and knee or elbow involvements. No association found between disease duration and symptoms, examination findings, radiological findings or AcroQoL. Conclusion: Joint degenerative changes detected in 60% of acromegalic patients, and affect quality of life, Regular evaluation of joint symptoms is recommended in the management of acromegalic patients. S-31","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"25 1","pages":"7-7"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79466949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/tjem.20182202-s19
B. Balsak, Z. Pekkolay, Mehmet Güven, A. Tuzcu
{"title":"Testicular Adrenal Rest Tumor","authors":"B. Balsak, Z. Pekkolay, Mehmet Güven, A. Tuzcu","doi":"10.25179/tjem.20182202-s19","DOIUrl":"https://doi.org/10.25179/tjem.20182202-s19","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"1 1","pages":"19-19"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80603019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.25179/TJEM.2017-56526
A. Unal, O. Tarçin, G. Demirci, E. Demiralay, A. Mansur, Şemsi Yıldız, N. G. Demirag
{"title":"Two cases of bullous pemphigoid induced by vildagliptin","authors":"A. Unal, O. Tarçin, G. Demirci, E. Demiralay, A. Mansur, Şemsi Yıldız, N. G. Demirag","doi":"10.25179/TJEM.2017-56526","DOIUrl":"https://doi.org/10.25179/TJEM.2017-56526","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"11 2 1","pages":"0-0"},"PeriodicalIF":0.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80627851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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