首页 > 最新文献

Turkish Journal of Endocrinology and Metabolism最新文献

英文 中文
Steroid Secreting Dedifferentiated Liposarcoma: A Unique Presentation 分泌类固醇的去分化脂肪肉瘤:一种独特的表现
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-71188
L. R. Santos, M. Duarte, J. V. L. Júnior
{"title":"Steroid Secreting Dedifferentiated Liposarcoma: A Unique Presentation","authors":"L. R. Santos, M. Duarte, J. V. L. Júnior","doi":"10.25179/tjem.2019-71188","DOIUrl":"https://doi.org/10.25179/tjem.2019-71188","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"210 1","pages":"101-104"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77616577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coexistence of Papillary and Medullary Thyroid Carcinoma: A Rare Entity 甲状腺乳头状癌和髓样癌共存:一种罕见的实体
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-72499
Emel Bayrak, R. Serter
Introduction Papillary thyroid carcinoma (PTC) are the most common of all thyroid cancers (>70%). It originates from follicular thyroid cells and shows multifocal growth in nearly 29% cases. Immunohistochemical results of PTC are positive for thyroglobulin and Thyroid Transcription Factor-1 (TTF-1). PTC cells are negative for calcitonin, Carcinoembryonic Antigen (CEA), and chromogranin. PTC The coexistence of different types of thyroid carcinomas is rather unusual. It has been considered coincidental and linked to the growing incidence of papillary thyroid carcinoma (PTC). This paper presents a case of multifocal PTC and coexistent medullary thyroid carcinoma (MTC) distinct from each other, along with PTC lymph node metastasis. The 44year-old female patient underwent subtotal thyroidectomy with a pre-operative diagnosis of multinodular goiter. Histological reports revealed PTC in the right lobe and PTC beside a tumoral area morphologically suspicious for MTC in the left thyroid lobe. Immunohistochemistry confirmed the diagnosis of MTC. Post-operative ultrasound and subsequent fine needle aspiration biopsy revealed lymph node metastases of PTC in the right anterior cervical area. Complementary thyroidectomy, central neck dissection, and right modified neck dissection were carried out with subsequent I-131 ablation therapy. In conclusion, the biological behaviors and prognoses of MTC and PTC are different. Therefore, the entity demands a different clinical approach in treatment and follow-up.
甲状腺乳头状癌(PTC)是最常见的甲状腺癌(>70%)。它起源于甲状腺滤泡细胞,在近29%的病例中表现为多灶性生长。PTC免疫组化结果显示甲状腺球蛋白和甲状腺转录因子-1 (TTF-1)阳性。PTC细胞降钙素、癌胚抗原(CEA)和嗜铬粒蛋白均阴性。不同类型甲状腺癌共存是相当罕见的。这被认为是巧合,并与甲状腺乳头状癌(PTC)的发病率上升有关。本文报告1例多灶性甲状腺髓样癌与不同类型的甲状腺髓样癌共存,并伴有甲状腺髓样癌淋巴结转移。44岁女性患者行甲状腺次全切除术,术前诊断为多结节性甲状腺肿。组织学报告显示PTC在右甲状腺叶和PTC旁边的肿瘤区域形态可疑的MTC在左甲状腺叶。免疫组化证实了MTC的诊断。术后超声及细针穿刺活检显示右侧颈前区PTC淋巴结转移。补充甲状腺切除术、中央颈部清扫术和右侧改良颈部清扫术,随后进行I-131消融治疗。综上所述,MTC和PTC的生物学行为和预后是不同的。因此,该实体在治疗和随访方面需要不同的临床方法。
{"title":"Coexistence of Papillary and Medullary Thyroid Carcinoma: A Rare Entity","authors":"Emel Bayrak, R. Serter","doi":"10.25179/tjem.2019-72499","DOIUrl":"https://doi.org/10.25179/tjem.2019-72499","url":null,"abstract":"Introduction Papillary thyroid carcinoma (PTC) are the most common of all thyroid cancers (>70%). It originates from follicular thyroid cells and shows multifocal growth in nearly 29% cases. Immunohistochemical results of PTC are positive for thyroglobulin and Thyroid Transcription Factor-1 (TTF-1). PTC cells are negative for calcitonin, Carcinoembryonic Antigen (CEA), and chromogranin. PTC The coexistence of different types of thyroid carcinomas is rather unusual. It has been considered coincidental and linked to the growing incidence of papillary thyroid carcinoma (PTC). This paper presents a case of multifocal PTC and coexistent medullary thyroid carcinoma (MTC) distinct from each other, along with PTC lymph node metastasis. The 44year-old female patient underwent subtotal thyroidectomy with a pre-operative diagnosis of multinodular goiter. Histological reports revealed PTC in the right lobe and PTC beside a tumoral area morphologically suspicious for MTC in the left thyroid lobe. Immunohistochemistry confirmed the diagnosis of MTC. Post-operative ultrasound and subsequent fine needle aspiration biopsy revealed lymph node metastases of PTC in the right anterior cervical area. Complementary thyroidectomy, central neck dissection, and right modified neck dissection were carried out with subsequent I-131 ablation therapy. In conclusion, the biological behaviors and prognoses of MTC and PTC are different. Therefore, the entity demands a different clinical approach in treatment and follow-up.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"149 1","pages":"168-172"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83962292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism 左甲状腺素治疗不同原因甲状腺功能减退患者三碘甲状腺原氨酸水平的比较
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-71845
M. Hemmatabadi, Samaneh Azizimanesh, F. Esfahanian, M. M. Tehrani, N. Shirzad
Objective: Several lines of evidence suggest that the symptoms of hypothyroidism, including psychological symptoms and metabolic effects, persist in a significant percentage of patients treated with levothyroxine (L-T4). A hypothesis to explain this phenomenon is that the triiodothyronine (L-T3) serum levels may not be completely normalized. This study aimed to compare the level of serum free T3 (FT3) in patients who are biochemically euthyroid after L-T4 monotherapy with different underlying causes of hypothyroidism. Material and Methods: This cross-sectional study was conducted on patients with hypothyroidism who received L-T4 monotherapy and were biochemically euthyroid. The serum levels of thyroid-stimulating hormone (TSH), free T4 (FT4), FT3, and FT3/FT4 ratio were measured in these patients. Patients were divided into three groups based on the cause of hypothyroidism (radioiodine therapy, thyroidectomy and Hashimoto), and the results of biochemical tests of the thyroid were compared in three groups. Results: Of the 78 patients studied, 12 (15.4%) cases were male, and 66 (84.6%) cases were female. Among the variables studied, only the mean value of FT3 was significantly different in the three groups (p=0.006), where the highest mean value was seen in the Hashimoto group, and the lowest mean value was seen in the radioiodine therapy group. Conclusion: The results of this study showed that although hypothyroidism patients can be optimally treated with L-T4 alone, in many of these patients, the level of FT3 will not be in therapeutic range, and the mean serum FT3 levels in these patients could be related to their hypothyroidism causes.
目的:多项证据表明,在接受左旋甲状腺素(L-T4)治疗的患者中,相当比例的甲状腺功能减退症状(包括心理症状和代谢影响)持续存在。一种解释这一现象的假说是三碘甲状腺原氨酸(L-T3)血清水平可能没有完全正常化。本研究旨在比较不同甲状腺功能减退潜在原因的L-T4单药治疗后生化甲状腺功能正常的患者血清游离T3 (FT3)水平。材料与方法:本横断面研究是针对接受L-T4单药治疗且生化功能正常的甲状腺功能减退患者进行的。检测患者血清促甲状腺激素(TSH)、游离T4 (FT4)、FT3及FT3/FT4比值。根据引起甲状腺功能减退的原因将患者分为三组(放射碘治疗、甲状腺切除术和桥本),比较三组患者甲状腺生化检查结果。结果:78例患者中,男性12例(15.4%),女性66例(84.6%)。在研究的变量中,只有FT3的平均值在三组之间有显著差异(p=0.006),其中桥本组的平均值最高,放射性碘治疗组的平均值最低。结论:本研究结果显示,虽然单纯使用L-T4治疗甲状腺功能减退患者效果最佳,但许多患者FT3水平不在治疗范围内,这些患者的平均血清FT3水平可能与其甲状腺功能减退的病因有关。
{"title":"Comparison of Triiodothyronine Level in Patients Treated with Levothyroxine for Different Causes of Hypothyroidism","authors":"M. Hemmatabadi, Samaneh Azizimanesh, F. Esfahanian, M. M. Tehrani, N. Shirzad","doi":"10.25179/tjem.2019-71845","DOIUrl":"https://doi.org/10.25179/tjem.2019-71845","url":null,"abstract":"Objective: Several lines of evidence suggest that the symptoms of hypothyroidism, including psychological symptoms and metabolic effects, persist in a significant percentage of patients treated with levothyroxine (L-T4). A hypothesis to explain this phenomenon is that the triiodothyronine (L-T3) serum levels may not be completely normalized. This study aimed to compare the level of serum free T3 (FT3) in patients who are biochemically euthyroid after L-T4 monotherapy with different underlying causes of hypothyroidism. Material and Methods: This cross-sectional study was conducted on patients with hypothyroidism who received L-T4 monotherapy and were biochemically euthyroid. The serum levels of thyroid-stimulating hormone (TSH), free T4 (FT4), FT3, and FT3/FT4 ratio were measured in these patients. Patients were divided into three groups based on the cause of hypothyroidism (radioiodine therapy, thyroidectomy and Hashimoto), and the results of biochemical tests of the thyroid were compared in three groups. Results: Of the 78 patients studied, 12 (15.4%) cases were male, and 66 (84.6%) cases were female. Among the variables studied, only the mean value of FT3 was significantly different in the three groups (p=0.006), where the highest mean value was seen in the Hashimoto group, and the lowest mean value was seen in the radioiodine therapy group. Conclusion: The results of this study showed that although hypothyroidism patients can be optimally treated with L-T4 alone, in many of these patients, the level of FT3 will not be in therapeutic range, and the mean serum FT3 levels in these patients could be related to their hypothyroidism causes.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"46 1","pages":"138-143"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72999866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Serum 25(OH) Vitamin D Levels in Severely Obese Patients Evaluated Before Bariatric Surgery 减肥手术前评估严重肥胖患者血清25(OH)维生素D水平
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-71778
H. G. Gunhan, M. Uygur, E. Imre, O. Elbasan, D. Yavuz
Objective: Obesity is a risk factor for vitamin D deficiency, which is reported to be detected differently in each population. This study aimed to evaluate the 25(OH) vitamin D (25(OH)D) levels, intact parathormone (iPTH) levels, and their relationship with body mass index (BMI) in obese patients, screened prior to bariatric surgery. Material and Methods: This retrospective study comprised of 1.082 obese patients (41±10 years, female/male: 823/259) who were candidates for bariatric surgery. BMI, waist circumference (WC), serum 25(OH)D, iPTH, calcium, phosphorus values of these patients were recorded from patient files. Results: BMI, WC, iPTH, and 25(OH)D levels were 48±8.9 kg/m2, 128±11.9 cm, 64±36 pg/mL, and 15±18 ng/mL, respectively. Mean 25(OH)D level of 79.1% of the patients belonged to the deficiency range. Very low 25(OH) vitamin D levels (<10 ng/mL) were witnessed among 40.9% (443/1.082) of the study group. Female obese subjects possessed significantly lower serum 25(OH)D levels as compared to male obese patients. Significant negative correlations were perceived between 25(OH)D levels and iPTH (r=-0.34, p<0.0001), BMI (r=-0.20, p<0.0001), and waist circumferences (r=-0.14, p=0.002) in the whole group. Multivariate analysis indicated that BMI to be an independent risk factor for vitamin D deficiency. Conclusion: A high rate of vitamin D deficiency was documented in our morbidly obese patients who were candidates for bariatric surgery. BMI is a determinant of 25(OH)D levels. It is essential to screen for vitamin D deficiency and possible osteomalacia among the candidates for bariatric surgery of obese patients and should be treated appropriately before bariatric surgery.
目的:肥胖是维生素D缺乏症的一个危险因素,据报道,在每个人群中,维生素D缺乏症的检测情况不同。本研究旨在评估25(OH)维生素D (25(OH)D)水平、完整甲状旁激素(iPTH)水平及其与肥胖患者体重指数(BMI)的关系,在减肥手术前进行筛查。材料与方法:本回顾性研究纳入1.082例肥胖患者(41±10岁,女/男:823/259),均为减肥手术候选者。从患者档案中记录BMI、腰围(WC)、血清25(OH)D、iPTH、钙、磷值。结果:BMI、WC、iPTH、25(OH)D水平分别为48±8.9 kg/m2、128±11.9 cm、64±36 pg/mL、15±18 ng/mL。平均25(OH)D水平79.1%的患者属于缺乏范围。研究组中40.9%(443/1.082)的25(OH)维生素D水平非常低(<10 ng/mL)。与男性肥胖患者相比,女性肥胖患者血清25(OH)D水平显著降低。全组25(OH)D水平与iPTH (r=-0.34, p<0.0001)、BMI (r=-0.20, p<0.0001)、腰围(r=-0.14, p=0.002)呈显著负相关。多因素分析表明,BMI是维生素D缺乏的独立危险因素。结论:在我们的病态肥胖患者中,维生素D缺乏率很高,这些患者是减肥手术的候选者。BMI是25(OH)D水平的决定因素。在肥胖患者进行减肥手术的候选者中筛查维生素D缺乏症和可能的骨软化症是必要的,在减肥手术前应适当治疗。
{"title":"Serum 25(OH) Vitamin D Levels in Severely Obese Patients Evaluated Before Bariatric Surgery","authors":"H. G. Gunhan, M. Uygur, E. Imre, O. Elbasan, D. Yavuz","doi":"10.25179/tjem.2019-71778","DOIUrl":"https://doi.org/10.25179/tjem.2019-71778","url":null,"abstract":"Objective: Obesity is a risk factor for vitamin D deficiency, which is reported to be detected differently in each population. This study aimed to evaluate the 25(OH) vitamin D (25(OH)D) levels, intact parathormone (iPTH) levels, and their relationship with body mass index (BMI) in obese patients, screened prior to bariatric surgery. Material and Methods: This retrospective study comprised of 1.082 obese patients (41±10 years, female/male: 823/259) who were candidates for bariatric surgery. BMI, waist circumference (WC), serum 25(OH)D, iPTH, calcium, phosphorus values of these patients were recorded from patient files. Results: BMI, WC, iPTH, and 25(OH)D levels were 48±8.9 kg/m2, 128±11.9 cm, 64±36 pg/mL, and 15±18 ng/mL, respectively. Mean 25(OH)D level of 79.1% of the patients belonged to the deficiency range. Very low 25(OH) vitamin D levels (<10 ng/mL) were witnessed among 40.9% (443/1.082) of the study group. Female obese subjects possessed significantly lower serum 25(OH)D levels as compared to male obese patients. Significant negative correlations were perceived between 25(OH)D levels and iPTH (r=-0.34, p<0.0001), BMI (r=-0.20, p<0.0001), and waist circumferences (r=-0.14, p=0.002) in the whole group. Multivariate analysis indicated that BMI to be an independent risk factor for vitamin D deficiency. Conclusion: A high rate of vitamin D deficiency was documented in our morbidly obese patients who were candidates for bariatric surgery. BMI is a determinant of 25(OH)D levels. It is essential to screen for vitamin D deficiency and possible osteomalacia among the candidates for bariatric surgery of obese patients and should be treated appropriately before bariatric surgery.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"106 1","pages":"115-121"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79257684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between C-Peptide Index and Proteinuria in Patients with Type 2 Diabetes Mellitus 2型糖尿病患者c肽指数与蛋白尿的关系
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-71377
B. Katipoglu, M. Comoglu, I. Ateş, N. Yılmaz, D. Berker
Objective: Though the C-peptide index (CPI) has been a reliable marker for estimation of the beta-cell reserve, its association with microvascular complications in Type 2 diabetes mellitus (DM) patients has not been elucidated as yet. This study, therefore, aimed to investigate the relationship between C-peptide levels and CPI with microvascular complications in Type 2 DM patients. Material and Methods: Type 2 DM patients, over 18 years of age, whose C-peptide levels were analyzed in the endocrinology and internal medicine clinics between 2014 and 2018, having normal kidney functions (glomerular filtration rate >60 mL/min) and who are not dependent on any insulin secretagogue oral antidiabetic agent (i.e., sulfonylurea) were enrolled the study. Blood samples were collected after at least 12 h of fasting, without any drug or insulin administration. Hemogram, hemoglobin A1c (HbA1c), lipid, glucose, C-peptide parameters were analyzed from the same serum sample. The patients were classified into three groups according to the spot urine albumin/creatinine ratio. Patients with no proteinuria, patients with microalbuminuria, and patients with macroalbuminuria were defined as group 1, group 2, and group 3, respectively. Results: A statistically significant difference between CPI levels in the groups was observed (p<0.001). CPI levels of Groups 2 and 3 were lower than that of group 1 (p=0.007 and p<0.001). In addition, the CPI level of group 3 was significantly lower than that of group 2 (p=0.015). An inverse association between CPI level and proteinuria was thus recognized. HbA1c and proteinuria were found to be positively correlated (p<0.001). Conclusion: This study highlights the association between C-peptide, CPI, and diabetic nephropathy in Type 2 DM patients.
目的:虽然c肽指数(CPI)是估计β细胞储备的可靠指标,但其与2型糖尿病(DM)患者微血管并发症的关系尚不清楚。因此,本研究旨在探讨2型糖尿病患者c肽水平与CPI与微血管并发症的关系。材料与方法:选取2014 - 2018年内分泌内科门诊c肽水平分析的18岁以上、肾功能正常(肾小球滤过率bbb60 mL/min)、不依赖胰岛素促分泌型口服降糖药(如磺脲类)的2型糖尿病患者为研究对象。禁食至少12小时后采集血液样本,不使用任何药物或胰岛素。分析同一血清的血象、糖化血红蛋白(HbA1c)、血脂、葡萄糖、c肽等参数。根据尿白蛋白/肌酐比值将患者分为三组。无蛋白尿患者、微量白蛋白尿患者和大量白蛋白尿患者分别定义为1组、2组和3组。结果:两组间CPI水平差异有统计学意义(p<0.001)。2、3组CPI水平均低于1组(p=0.007, p<0.001)。此外,第3组的CPI水平显著低于第2组(p=0.015)。CPI水平与蛋白尿呈负相关。HbA1c与蛋白尿呈正相关(p<0.001)。结论:本研究强调了c肽、CPI与2型DM患者糖尿病肾病之间的关系。
{"title":"The Relationship Between C-Peptide Index and Proteinuria in Patients with Type 2 Diabetes Mellitus","authors":"B. Katipoglu, M. Comoglu, I. Ateş, N. Yılmaz, D. Berker","doi":"10.25179/tjem.2019-71377","DOIUrl":"https://doi.org/10.25179/tjem.2019-71377","url":null,"abstract":"Objective: Though the C-peptide index (CPI) has been a reliable marker for estimation of the beta-cell reserve, its association with microvascular complications in Type 2 diabetes mellitus (DM) patients has not been elucidated as yet. This study, therefore, aimed to investigate the relationship between C-peptide levels and CPI with microvascular complications in Type 2 DM patients. Material and Methods: Type 2 DM patients, over 18 years of age, whose C-peptide levels were analyzed in the endocrinology and internal medicine clinics between 2014 and 2018, having normal kidney functions (glomerular filtration rate >60 mL/min) and who are not dependent on any insulin secretagogue oral antidiabetic agent (i.e., sulfonylurea) were enrolled the study. Blood samples were collected after at least 12 h of fasting, without any drug or insulin administration. Hemogram, hemoglobin A1c (HbA1c), lipid, glucose, C-peptide parameters were analyzed from the same serum sample. The patients were classified into three groups according to the spot urine albumin/creatinine ratio. Patients with no proteinuria, patients with microalbuminuria, and patients with macroalbuminuria were defined as group 1, group 2, and group 3, respectively. Results: A statistically significant difference between CPI levels in the groups was observed (p<0.001). CPI levels of Groups 2 and 3 were lower than that of group 1 (p=0.007 and p<0.001). In addition, the CPI level of group 3 was significantly lower than that of group 2 (p=0.015). An inverse association between CPI level and proteinuria was thus recognized. HbA1c and proteinuria were found to be positively correlated (p<0.001). Conclusion: This study highlights the association between C-peptide, CPI, and diabetic nephropathy in Type 2 DM patients.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"15 1","pages":"23-28"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80134523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Hyperandrogenemia in Women with Prolactinoma 催乳素瘤妇女高雄激素血症的评价
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-72018
M. Ünal, Z. Karaca, K. Ünlühızarcı, F. Keleştemur
Objective: Differential diagnosis of androgen excess disorders revealed the occurrence of hyperprolactinemia. However, an elevated level of prolactin (hyperprolactinemia) is a very infrequent cause of hyperandrogenemia in clinical practice. This study aimed to investigate the presence of hyperandrogenism/hyperandrogenemia in women with prolactinoma before and after treatment with cabergoline. Material and Methods: Twenty women diagnosed with prolactinoma in the recent past and 15 healthy women between the ages of 18 to 50 were enrolled in the study. Patients were evaluated at the baseline and after six months of cabergoline treatment. Patients were carefully noted for any signs and symptoms of hyperandrogenemia and concentration of androgen in blood. Further, adrenocorticotropin stimulation test was performed to analyze cortisol, dehydroepiandrosterone sulfate (DHEAS), androstenedione, 11-deoxycortisol (11-S), and 17-hydroxyprogesterone (17-OHP) responses. Results: A significantly higher level of prolactin compared to the control group was seen in prolactinoma patients, which reverted to normal levels after cabergoline treatment. Estradiol (E2) concentration was lower in patients with prolactinoma than control group and it did not show a significant increase after being treated with cabergoline. Patients with prolactinoma exhibited decreased sex hormone-binding globulin (SHBG) concentration in blood, which also increased significantly after the treatment. The levels of basal androstenedione, DHEAS, 17-OH progesterone, 11-S, and cortisol were found to be similar between the two groups. Basal and stimulated DHEAS and androstenedione levels decreased significantly after cabergoline treatment in prolactinoma patients. The presence of acne, hirsutism, and androgenic alopecia were similar in both groups. Pelvic ultrasonography revealed polycystic ovary (PCO) in nine patients with prolactinoma, which was significantly more frequent than in the control group. Among the 9 PCO patients, normal ovarian morphology was restored in three patients after the treatment. Conclusion: From the data, it may be suggested that hyperprolactinemia may not lead to clinically significant hyperandrogenemia and hirsutism. Moreover, the treatment of hyperprolactinemia does not lead to significant improvement in hirsutism score of the patients, if exists.
目的:高催乳素血症对雄激素过多障碍的鉴别诊断。然而,在临床实践中,催乳素水平升高(高催乳素血症)是高雄激素血症的一个非常罕见的原因。本研究旨在探讨卡麦角林治疗前后催乳素瘤女性患者是否存在高雄激素症/高雄激素血症。材料和方法:20名最近被诊断为泌乳素瘤的妇女和15名年龄在18至50岁之间的健康妇女参加了这项研究。在基线和卡麦角林治疗6个月后对患者进行评估。仔细记录患者的任何体征和症状高雄激素血症和雄激素浓度在血液中。进一步,进行促肾上腺皮质激素刺激试验,分析皮质醇、硫酸脱氢表雄酮(DHEAS)、雄烯二酮、11-脱氧皮质醇(11-S)和17-羟基孕酮(17-OHP)的反应。结果:催乳素瘤患者催乳素水平明显高于对照组,经卡麦角林治疗后恢复正常。催乳素瘤患者雌二醇(E2)浓度低于对照组,经卡麦角林治疗后雌二醇(E2)浓度无明显升高。催乳素瘤患者血液中性激素结合球蛋白(SHBG)浓度降低,治疗后也显著升高。基础雄烯二酮、DHEAS、17-OH孕酮、11-S和皮质醇水平在两组之间相似。卡麦角林治疗后催乳素瘤患者的基础和刺激DHEAS和雄烯二酮水平显著降低。痤疮、多毛和雄激素性脱发的存在在两组中相似。9例催乳素瘤患者盆腔超声检查显示多囊卵巢(PCO),发生率明显高于对照组。9例PCO患者中,3例经治疗后卵巢形态恢复正常。结论:高催乳素血症可能不会导致临床上显著的高雄激素血症和多毛症。此外,高泌乳素血症的治疗没有导致多毛症患者评分的显著改善,如果存在的话。
{"title":"Evaluation of Hyperandrogenemia in Women with Prolactinoma","authors":"M. Ünal, Z. Karaca, K. Ünlühızarcı, F. Keleştemur","doi":"10.25179/tjem.2019-72018","DOIUrl":"https://doi.org/10.25179/tjem.2019-72018","url":null,"abstract":"Objective: Differential diagnosis of androgen excess disorders revealed the occurrence of hyperprolactinemia. However, an elevated level of prolactin (hyperprolactinemia) is a very infrequent cause of hyperandrogenemia in clinical practice. This study aimed to investigate the presence of hyperandrogenism/hyperandrogenemia in women with prolactinoma before and after treatment with cabergoline. Material and Methods: Twenty women diagnosed with prolactinoma in the recent past and 15 healthy women between the ages of 18 to 50 were enrolled in the study. Patients were evaluated at the baseline and after six months of cabergoline treatment. Patients were carefully noted for any signs and symptoms of hyperandrogenemia and concentration of androgen in blood. Further, adrenocorticotropin stimulation test was performed to analyze cortisol, dehydroepiandrosterone sulfate (DHEAS), androstenedione, 11-deoxycortisol (11-S), and 17-hydroxyprogesterone (17-OHP) responses. Results: A significantly higher level of prolactin compared to the control group was seen in prolactinoma patients, which reverted to normal levels after cabergoline treatment. Estradiol (E2) concentration was lower in patients with prolactinoma than control group and it did not show a significant increase after being treated with cabergoline. Patients with prolactinoma exhibited decreased sex hormone-binding globulin (SHBG) concentration in blood, which also increased significantly after the treatment. The levels of basal androstenedione, DHEAS, 17-OH progesterone, 11-S, and cortisol were found to be similar between the two groups. Basal and stimulated DHEAS and androstenedione levels decreased significantly after cabergoline treatment in prolactinoma patients. The presence of acne, hirsutism, and androgenic alopecia were similar in both groups. Pelvic ultrasonography revealed polycystic ovary (PCO) in nine patients with prolactinoma, which was significantly more frequent than in the control group. Among the 9 PCO patients, normal ovarian morphology was restored in three patients after the treatment. Conclusion: From the data, it may be suggested that hyperprolactinemia may not lead to clinically significant hyperandrogenemia and hirsutism. Moreover, the treatment of hyperprolactinemia does not lead to significant improvement in hirsutism score of the patients, if exists.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"11 2 1","pages":"55-62"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81248828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet Activation is a Risk Factor for Obesity 血小板活化是肥胖的一个危险因素
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-72995
S. Çeçen
Objective: Obesity is known to be a triggering factor for many chronic diseases. Blood parameters, especially platelet (PLT)-related factors, have gained importance for a better understanding of obesity. In this study, we investigated the correlation between PLT-related parameters and bodily factors to enhance our knowledge of this important area of research. Material and Methods: Consenting volunteers between 18 and 65 years were included in the study. Their heights, weights, body mass indices (BMI), fat percentages, fat masses (FM), and fat-free masses (FFM) were determined. Fat mass index (FMI=fat mass/height m2) and fat-free mass index (FFMI=fat free mass/height m2) were calculated. Blood samples were taken to determine the parameters such as PLT, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). Results: In males, PLT increased with weight, fat percentage, FM, and FMI. However, there was no change in PCT values with these parameters. In females, PLT decreased with age, increased with weight, BMI, fat percentage, FM, FFM, and FMI. PCT increased with weight, BMI, fat percentage, FM, FFM, and FMI. Conclusion: A significant relationship between PLT activation and body fat content was observed in both genders in the present study. Thus, these blood parameters can be a useful tool for investigating inflammation-related complications in obese individuals. It is speculated that obese individuals may be encouraged toward becoming thrombocyte apheresis donors to reduce their PLT counts, which may lead to a decrease in the risk of obesity-related inflammation in such individuals.
目的:肥胖是许多慢性疾病的触发因素。血液参数,特别是血小板(PLT)相关因素,对于更好地理解肥胖已经变得很重要。在这项研究中,我们调查了plt相关参数与身体因素之间的相关性,以增强我们对这一重要研究领域的认识。材料和方法:年龄在18到65岁之间的自愿志愿者被纳入研究。测定其身高、体重、体质指数(BMI)、脂肪百分比、脂肪质量(FM)和无脂质量(FFM)。计算脂肪质量指数(FMI=脂肪质量/高度m2)和无脂质量指数(FFMI=无脂质量/高度m2)。取血测定血小板积(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、血小板电积(PCT)等参数。结果:男性PLT随着体重、脂肪率、FM和FMI的增加而增加。然而,这些参数没有改变PCT值。在女性中,PLT随着年龄的增长而下降,随着体重、BMI、脂肪百分比、FM、FFM和FMI的增加而增加。PCT随体重、BMI、脂肪率、FM、FFM和FMI的增加而增加。结论:在本研究中,在两性中均观察到PLT激活与体脂含量之间的显著关系。因此,这些血液参数可以成为研究肥胖个体炎症相关并发症的有用工具。据推测,肥胖个体可能被鼓励成为血小板分离供体以减少其血小板计数,这可能导致肥胖相关炎症的风险降低。
{"title":"Platelet Activation is a Risk Factor for Obesity","authors":"S. Çeçen","doi":"10.25179/tjem.2019-72995","DOIUrl":"https://doi.org/10.25179/tjem.2019-72995","url":null,"abstract":"Objective: Obesity is known to be a triggering factor for many chronic diseases. Blood parameters, especially platelet (PLT)-related factors, have gained importance for a better understanding of obesity. In this study, we investigated the correlation between PLT-related parameters and bodily factors to enhance our knowledge of this important area of research. Material and Methods: Consenting volunteers between 18 and 65 years were included in the study. Their heights, weights, body mass indices (BMI), fat percentages, fat masses (FM), and fat-free masses (FFM) were determined. Fat mass index (FMI=fat mass/height m2) and fat-free mass index (FFMI=fat free mass/height m2) were calculated. Blood samples were taken to determine the parameters such as PLT, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). Results: In males, PLT increased with weight, fat percentage, FM, and FMI. However, there was no change in PCT values with these parameters. In females, PLT decreased with age, increased with weight, BMI, fat percentage, FM, FFM, and FMI. PCT increased with weight, BMI, fat percentage, FM, FFM, and FMI. Conclusion: A significant relationship between PLT activation and body fat content was observed in both genders in the present study. Thus, these blood parameters can be a useful tool for investigating inflammation-related complications in obese individuals. It is speculated that obese individuals may be encouraged toward becoming thrombocyte apheresis donors to reduce their PLT counts, which may lead to a decrease in the risk of obesity-related inflammation in such individuals.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"40 1","pages":"132-137"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87831478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Comparison of New and Old Body Shape Indices to Estimate Body Fat in Obese and Morbid Obese Turkish Females 土耳其肥胖和病态肥胖女性估算体脂的新旧体型指数比较
IF 0.2 Q4 Medicine Pub Date : 2020-01-01 DOI: 10.25179/tjem.2019-66730
Merve Melikoğlu, Can Öner, S. Tüzün, Ş. Temizkan, Ekrem Orbay
Objective: The estimation of fat mass with indirect techniques is beneficial in daily clinical practice. This study aimed to compare new and old body shape indices using bioimpedance analysis for the assessment of body fat mass in obese and morbid obese Turkish females. Material and Methods: Four hundred thirty-eight obese and morbid obese females were enrolled in the study. Anthropometric measurements of the study participants were completed using standard techniques. Body mass index (BMI), body adiposity index (BAI), a body shape index, waist to hip ratio and body roundness index (BRI) were calculated. The body fat ratio was evaluated using TANITA-48M. Results: All the anthropometric indices except waist circumference, waist-to-hip ratio, and ABSI correlated with body fat (%). BMI and BAI were the best predictors of body fat ratio derived from bioimpedance analysis for all participants. Only for obese females, BAI alone as well as BAI and BMI together were the best predictive methods of body fat (%). In the morbid obese group, BAI alone proved to be the best predictive method for body fat (%) estimation. Conclusion: In clinical practice, the determination of body fat ratio with indirect techniques may help physicians estimate the risk of diseases in obese and morbid obese patients. BAI can help estimate body fat ratio easily.
目的:利用间接技术估算脂肪量有助于日常临床实践。本研究旨在比较新的和旧的体型指标,使用生物阻抗分析来评估肥胖和病态肥胖的土耳其女性的体脂量。材料和方法:438名肥胖和病态肥胖女性被纳入研究。研究参与者的人体测量使用标准技术完成。计算体重指数(BMI)、体脂指数(BAI)、体型指数、腰臀比和体圆度指数(BRI)。采用TANITA-48M评估体脂比。结果:除腰围、腰臀比、ABSI外,所有人体测量指标均与体脂(%)相关。BMI和BAI是所有参与者生物阻抗分析得出的体脂比的最佳预测因子。仅对于肥胖女性,单独使用BAI以及BAI与BMI联合使用是体脂(%)的最佳预测方法。在病态肥胖组中,单独BAI被证明是估计体脂(%)的最佳预测方法。结论:在临床实践中,采用间接技术测定体脂比可以帮助医生估计肥胖和病态肥胖患者的疾病风险。BAI可以帮助估算身体脂肪比。
{"title":"Comparison of New and Old Body Shape Indices to Estimate Body Fat in Obese and Morbid Obese Turkish Females","authors":"Merve Melikoğlu, Can Öner, S. Tüzün, Ş. Temizkan, Ekrem Orbay","doi":"10.25179/tjem.2019-66730","DOIUrl":"https://doi.org/10.25179/tjem.2019-66730","url":null,"abstract":"Objective: The estimation of fat mass with indirect techniques is beneficial in daily clinical practice. This study aimed to compare new and old body shape indices using bioimpedance analysis for the assessment of body fat mass in obese and morbid obese Turkish females. Material and Methods: Four hundred thirty-eight obese and morbid obese females were enrolled in the study. Anthropometric measurements of the study participants were completed using standard techniques. Body mass index (BMI), body adiposity index (BAI), a body shape index, waist to hip ratio and body roundness index (BRI) were calculated. The body fat ratio was evaluated using TANITA-48M. Results: All the anthropometric indices except waist circumference, waist-to-hip ratio, and ABSI correlated with body fat (%). BMI and BAI were the best predictors of body fat ratio derived from bioimpedance analysis for all participants. Only for obese females, BAI alone as well as BAI and BMI together were the best predictive methods of body fat (%). In the morbid obese group, BAI alone proved to be the best predictive method for body fat (%) estimation. Conclusion: In clinical practice, the determination of body fat ratio with indirect techniques may help physicians estimate the risk of diseases in obese and morbid obese patients. BAI can help estimate body fat ratio easily.","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"43 1","pages":"1-8"},"PeriodicalIF":0.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81550627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Complications of Stump Healing Among Diabetic Population 糖尿病患者残肢愈合的并发症
IF 0.2 Q4 Medicine Pub Date : 2018-06-19 DOI: 10.25179/TJEM.2018-59880
S. Ashraff, Muhammad A. Siddiqui, D. Santos, T. Carline
{"title":"Complications of Stump Healing Among Diabetic Population","authors":"S. Ashraff, Muhammad A. Siddiqui, D. Santos, T. Carline","doi":"10.25179/TJEM.2018-59880","DOIUrl":"https://doi.org/10.25179/TJEM.2018-59880","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"174 1","pages":"91-97"},"PeriodicalIF":0.2,"publicationDate":"2018-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73076421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Evaluation of causes of high parathyroid hormone levels in elderly 老年人甲状旁腺激素水平高的原因评价
IF 0.2 Q4 Medicine Pub Date : 2018-05-08 DOI: 10.1530/ENDOABS.56.EP30
P. Tutuncuoğlu, F. Saraç
{"title":"Evaluation of causes of high parathyroid hormone levels in elderly","authors":"P. Tutuncuoğlu, F. Saraç","doi":"10.1530/ENDOABS.56.EP30","DOIUrl":"https://doi.org/10.1530/ENDOABS.56.EP30","url":null,"abstract":"","PeriodicalId":42868,"journal":{"name":"Turkish Journal of Endocrinology and Metabolism","volume":"29 1","pages":"46-46"},"PeriodicalIF":0.2,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74907619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Turkish Journal of Endocrinology and Metabolism
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1