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2021 IEEE International Symposium on Medical Measurements and Applications (MeMeA)最新文献

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Detection of Sleep Apnea from Single-Lead ECG: Comparison of Deep Learning Algorithms 单导联心电图检测睡眠呼吸暂停:深度学习算法的比较
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478745
Mahsa Bahrami, M. Forouzanfar
Apnea is a prevalent sleep disorder which has detrimental impacts on human health and quality of life. Accurate automatic algorithms for the detection of sleep apnea are needed for analyzing long-term sleep data and monitoring and management of its side effects and consequences. Among different approaches for automatic detection of sleep apnea from biosignals, deep learning algorithms are of particular interest as, unlike conventional machine learning algorithms, they do not rely on expert crafted features. In this paper, we developed and evaluated a number of different deep learning models for the detection of sleep apnea from a single-lead electrocardiogram (ECG) signal. ECG R-peak amplitude and R-R intervals were extracted, and power spectral analysis was performed to align the R-peak amplitude and the R-R intervals in frequency domain. Convolutional neural network (CNN), long short-term memory (LSTM), bidirectional LSTM, gated recurrent unit, and deep hybrid models were implemented and analyzed. The performance of deep learning algorithms was evaluated on an apnea-ECG dataset of 70 recordings divided into a learning set of 35 records and a test of 35 records. The best accuracy, sensitivity, specificity, and F1-score on the test data were 80.67%, 75.04%, 84.13%, and 74.72%, respectively, with a hybrid CNN and LSTM network. The results show promise toward improved apnea detection using deep learning.
呼吸暂停是一种普遍存在的睡眠障碍,对人类健康和生活质量有不利影响。需要精确的自动算法来检测睡眠呼吸暂停,以分析长期睡眠数据并监测和管理其副作用和后果。在从生物信号中自动检测睡眠呼吸暂停的不同方法中,深度学习算法特别令人感兴趣,因为与传统的机器学习算法不同,它们不依赖于专家精心制作的特征。在本文中,我们开发并评估了许多不同的深度学习模型,用于从单导联心电图(ECG)信号中检测睡眠呼吸暂停。提取心电r -峰值幅度和R-R区间,进行功率谱分析,将r -峰值幅度和R-R区间在频域对齐。对卷积神经网络(CNN)、长短期记忆(LSTM)、双向LSTM、门控循环单元和深度混合模型进行了实现和分析。深度学习算法的性能在一个由70条记录组成的呼吸暂停-心电图数据集上进行评估,该数据集分为35条记录的学习集和35条记录的测试集。CNN和LSTM混合网络在测试数据上的准确率、灵敏度、特异性和f1评分分别为80.67%、75.04%、84.13%和74.72%。研究结果显示,利用深度学习改进呼吸暂停检测大有希望。
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引用次数: 18
Classification-Based Screening of Phlebopathic Patients using Smart Socks 使用智能袜子对静脉病患者进行分类筛查
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478688
Emanuele D'Angelantonio, Leandro Lucangeli, V. Camomilla, F. Mari, Guido Mascia, A. Pallotti
Telemedicine consists in the delivery of health care services, where patients and providers are separated by distance. Telemonitoring facilities play an important role in remote assistance programs, particularly in assisting patients suffering from chronic afflictions, such as phlebopathic diseases (e.g. chronic venous disease and diabetic foot). When these pathologies worsen, complications can be serious. In fact, foot deformities lead to variations of plantar load, formation of ulcers and, in the worst case, to amputation. Consequently, these pathologies cause huge expenses for the health care system. We propose a framework for screening and early detection of phlebopathic diseases insurgence, based on dynamic tests for functional assessment where patients wear sensorized socks. Socks used in this study integrate force and inertial sensors to provide information on plantar pressures and person’s movement. We show results of a feasibility study including 42 patients, with a balance of 21 healthy patients and 21 with phlebopathic diseases. Data gathered from wearables were automatically elaborated through machine learning techniques in order to obtain a binary classifier identifying whether or not a patient shows pathological gait. Results show that our best classifier has high positive predictive value and high sensitivity, with F1-score equal to 92.1%.
远程医疗包括提供卫生保健服务,患者和提供者因距离而分开。远程监测设施在远程援助方案中发挥着重要作用,特别是在帮助患有慢性疾病,如静脉病(如慢性静脉疾病和糖尿病足)的患者方面。当这些病理恶化时,并发症可能会很严重。事实上,足部畸形会导致足底负荷的变化,溃疡的形成,在最坏的情况下,导致截肢。因此,这些疾病给医疗保健系统带来了巨大的开支。我们提出了一个框架,筛选和早期发现静脉病叛乱,基于动态测试的功能评估,患者穿感测袜子。在这项研究中使用的袜子集成了力和惯性传感器,以提供足底压力和人的运动信息。我们展示了一项可行性研究的结果,包括42名患者,其中21名健康患者和21名静脉病患者。从可穿戴设备收集的数据通过机器学习技术自动细化,以获得识别患者是否表现出病态步态的二元分类器。结果表明,我们的最佳分类器具有较高的阳性预测值和较高的灵敏度,f1得分为92.1%。
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引用次数: 5
Gait Parameters of Elderly Subjects in Single-task and Dual-task with three different MIMU set-ups 三种不同MIMU设置下老年受试者单任务和双任务的步态参数
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478735
E. Digo, E. Panero, V. Agostini, L. Gastaldi
The increasing average age of the population emphasizes the strong correlation between cognitive decline and gait disorders of elderly people. Wearable technologies such as magnetic inertial measurement units (MIMUs) have been ascertained as a suitable solution for gait analysis. However, the relationship between human motion and cognitive impairments should still be investigated, considering outcomes of different MIMU set-ups. Accordingly, the aim of the present study was to compare single-task and dual-task walking of an elderly population by using three different MIMU set-ups and correlated algorithms (trunk, shanks, and ankles). Gait sessions of sixteen healthy elderly subjects were registered and spatio-temporal parameters were selected as outcomes of interest. The analysis focused both on the comparison of walking conditions and on the evaluation of differences among MIMU set-ups. Results pointed out the significant effect of cognition on walking speed (p = 0.03) and temporal parameters (p ≤ 0.05), but not on the symmetry of gait. In addition, the comparison among MIMU configurations highlighted a significant difference in the detection of gait stance and swing phases (for shanks-ankles comparison p < 0.001 in both single and dual tasks, for trunk-ankles comparison p < 0.001 in single task and p < 0.01 in dual task). Overall, cognitive impact and MIMU set-ups revealed to be fundamental aspects in the analysis of gait spatio-temporal parameters in a healthy elderly population.
人口平均年龄的增长强调了老年人认知能力下降与步态障碍之间的强烈相关性。磁性惯性测量单元(MIMUs)等可穿戴技术已被确定为步态分析的合适解决方案。然而,考虑到不同MIMU设置的结果,人类运动与认知障碍之间的关系仍有待研究。因此,本研究的目的是通过使用三种不同的MIMU设置和相关算法(躯干、小腿和脚踝)来比较老年人的单任务和双任务行走。对16名健康老年人的步态过程进行记录,选取时空参数作为感兴趣的结果。分析的重点是行走条件的比较和MIMU设置之间差异的评估。结果表明,认知对步行速度(p = 0.03)和时间参数(p≤0.05)有显著影响,但对步态对称性无显著影响。此外,MIMU配置之间的比较突出了步态姿态和摇摆相位检测的显著差异(单任务和双任务中小腿-脚踝比较p < 0.001,单任务中躯干-脚踝比较p < 0.001,双任务中p < 0.01)。总体而言,认知影响和MIMU设置揭示了健康老年人步态时空参数分析的基本方面。
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引用次数: 1
Automatic processing protocol to evaluate the impact of functional network damage and reorganization on cognitive functions after stroke 评估脑卒中后功能性网络损伤和重组对认知功能影响的自动处理协议
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478769
L. Svobodová, R. Janca, P. Jiruška
An ischemic stroke is a local lesion that disrupts the large-scale structural and functional connectivity of the brain. Although local, the ischemic stroke often leads to deficits in cognitive functions which can’t be explained by local brain damage. It is believed that stroke-induced large-scale network alteration represents the mechanisms responsible for a decline in cognitive functions which are dependent on large-scale integration. To gain insight into the pathophysiological principles of how a local lesion results in a global cognitive decline requires a reliable and robust algorithm that can quantify the relationship between cognitive functions and network properties. In this study, we have developed, optimized, and tested a processing pipeline to parameterize complex neuropsychological evaluation and determine the functional connectivity from high-density EEG recordings. The developed algorithm was applied on a cohort of 27 patients who suffered a stroke and who were underwent cognitive examinations and high-density EEG monitoring one and two years after the stroke. The developed automatic algorithm demonstrated that it can reliably estimate functional connectivity and that it is robust against the physiological and technical artifacts. The proposed processing pipeline allows an unbiased and quantitative characterization of cognitive performance and its comparison with functional connectivity alterations.
缺血性中风是一种局部病变,它破坏了大脑的大规模结构和功能连接。缺血性中风虽然是局部的,但往往导致认知功能的缺陷,这不能用局部脑损伤来解释。人们认为,中风引起的大规模网络改变代表了依赖于大规模整合的认知功能下降的机制。为了深入了解局部病变如何导致整体认知能力下降的病理生理原理,需要一种可靠且稳健的算法,可以量化认知功能和网络特性之间的关系。在这项研究中,我们开发、优化并测试了一种处理管道,用于参数化复杂的神经心理学评估,并从高密度脑电图记录中确定功能连接。开发的算法应用于27名中风患者,他们在中风后1年和2年接受认知检查和高密度脑电图监测。所开发的自动算法表明,它可以可靠地估计功能连接,并且对生理和技术伪像具有鲁棒性。提出的处理管道允许对认知表现进行公正和定量的表征,并将其与功能连接改变进行比较。
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引用次数: 0
Smartwatches selection: market analysis and metrological characterization on the measurement of number of steps 智能手表的选择:对步数测量的市场分析和计量特性
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478770
S. Casaccia, G. M. Revel, L. Scalise, Giacomo Cucchieri, L. Rossi
This paper is focused on identifying the accuracy of smartwatches (SWs) on the measurement of number of steps. Five SWs have been identified based on technical characteristics and costs from a list of 32 SWs available on the market. A metrological characterization on the selected SWs has been made on six subjects wearing all the SWs and doing walking activity with natural, slow and fast pace. R, R2 and statistical confidence, with coverage factor equal to 2, are computed considering videos as reference system to identify the number of steps. The overall statistical confidence is 4.2% for natural pace, 7.5% for the slow pace and 7.1% for the fast pace.
本文主要研究智能手表在步数测量上的准确性。根据技术特点和成本,我们从市面上可供选择的32种水处理设备中选出了5种。对6名受试者穿戴所有的SWs,进行自然、慢速和快速的步行活动,对所选的SWs进行计量学表征。以视频为参照系,计算R、R2和统计置信度,覆盖因子为2,识别步数。总体统计置信度自然步为4.2%,慢步为7.5%,快步为7.1%。
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引用次数: 1
Deep Convolutional Feature-Based Fluorescence-to-Color Image Registration 基于深度卷积特征的荧光-彩色图像配准
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478607
Xingxing Liu, Tri Quang, Wenxiang Deng, Yang Liu
Fluorescence imaging has been widely utilized in various clinical applications. As a functional imaging modality, NIR fluorescence imaging often does not offer sufficient structural details. Therefore, structural imaging such as color reflectance overlaid with fluorescence imaging represents a superior approach for surgical visualization. Image registration of color reflectance and NIR fluorescence is needed for accurate overlay. In this study, we have implemented a deep convolutional algorithm for feature-based fluorescence-to-color image registration. Software-hardware codesign was conducted. Several sets of experiments were performed on biological tissues to compare the performance of our algorithm and traditional methods. We have demonstrated the feasibility of deep convolutional feature-based fluorescence-to-color image registration. To our best knowledge, this is the first demonstration of deep learning-based image registration between fluorescence and color imageries.
荧光成像已广泛应用于各种临床应用。作为一种功能成像方式,近红外荧光成像往往不能提供足够的结构细节。因此,结构成像,如彩色反射叠加荧光成像是外科可视化的一种优越方法。为了实现准确的叠加,需要对彩色反射率和近红外荧光图像进行配准。在这项研究中,我们实现了一种基于特征的荧光到彩色图像配准的深度卷积算法。进行软硬件协同设计。在生物组织上进行了几组实验,比较了该算法与传统方法的性能。我们已经证明了基于深度卷积特征的荧光到彩色图像配准的可行性。据我们所知,这是荧光图像和彩色图像之间基于深度学习的图像配准的第一次演示。
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引用次数: 0
PsySuite, an Android App for behavioural tests in the temporal domain PsySuite,一个用于时间域行为测试的安卓应用程序
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478724
A. Inuggi, Alessia Tonelli, M. Gori
We present PsySuite, an Android App designed to perform multimodal behavioral tests in the temporal domain. This class of tests consists in delivering either unimodal or multimodal visual, acoustic and tactile stimuli and asking participants to evaluate their temporal features: duration, temporal distance between stimuli and simultaneity across different modalities. The accuracy and reproducibility of our stimuli production mechanism was evaluated with an oscilloscope on two different smartphones models. Then, we validated the App running two versions of the double-flash illusion (DFI) test in seven healthy adults. DFI was selected as it induces a perceptual illusion only when stimuli are precisely delivered within few milliseconds. We found the App could reliably produce stimuli with a minimum duration of 7 ms, 17 ms and 35 ms respectively for acoustic, visual and tactile stimuli. Oboe library outclassed AudioTrack solution in playing pairs of sounds, whilst visual and tactile performance was highly dependent on the smartphone’s model used. In the DFI test using "long" stimuli (35 ms) we did not find the flash illusion effect. We could run the "short" (audio: 7 ms, visual: 17 ms) stimuli version only with audio-visual stimuli and we found a strong effect consistent with the literature using classical experimental, PC-based, setups. These results suggest that our PsySuite App can be used to run highly demanding audio-visual psychophysics experiments obtaining the same effect found with classical setups.
我们提出PsySuite,一个安卓应用程序,旨在执行多模态行为测试在时间域。这类测试包括提供单模态或多模态视觉、听觉和触觉刺激,并要求参与者评估其时间特征:持续时间、刺激之间的时间距离和不同模态的同时性。我们的刺激产生机制的准确性和可重复性用示波器在两种不同的智能手机模型上进行了评估。然后,我们在7名健康成人中运行两个版本的双闪错觉(DFI)测试来验证应用程序。之所以选择DFI,是因为只有当刺激在几毫秒内精确传递时,它才会引起感知错觉。我们发现该应用程序可以可靠地产生最小持续时间分别为7 ms、17 ms和35 ms的听觉、视觉和触觉刺激。双簧管库在播放成对的声音时优于AudioTrack解决方案,而视觉和触觉性能高度依赖于所使用的智能手机型号。在使用“长”刺激(35 ms)的DFI测试中,我们没有发现闪光错觉效应。我们可以只使用视听刺激运行“短”(音频:7毫秒,视觉:17毫秒)刺激版本,我们发现使用经典实验,基于pc的设置的强烈效果与文献一致。这些结果表明,我们的PsySuite应用程序可以用于运行高要求的视听心理物理学实验,获得与经典设置相同的效果。
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引用次数: 0
Impact of Subject-specific Training Data in Anxiety Level Classification from Physiologic Data 特定科目训练数据对焦虑水平生理分类的影响
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478757
R. Selzler, A. Chan, J. Green
The autonomic nervous system is known for the fight or flight response. Anxiety affects the autonomic nervous system, causing heightened heart rate and electrodermal activity. This paper explores machine learning methods to predict two- and three-level anxiety in spider fearful individuals watching spider video clips in a controlled trial. Features are extracted from electrocardiogram and electrodermal time-series signals. Specifically, this paper explores the performance of such models as the amount of data pertaining to the test subject increases in the training set. Standard K-fold cross-validation is here compared to leaky group-fold cross-validation with sample imputation, where we systematically vary the the number of samples from the test subject that are included in the training set. While it is possible to reach 78% and 60% k-fold accuracy for a two- and three-level anxiety prediction, respectively, excluding all test subject data from the training set causes the accuracy to drop to 73% and 45%. The results demonstrate that the features and models used here do not generalize for inter-subject classification tasks and that care should be taken when splitting subject data between training and test data. Furthermore, our results address the "cold start problem" by providing an indication of how much data would be required from a new subject before accurate prediction of anxiety is possible from physiologic data.
自主神经系统以战斗或逃跑反应而闻名。焦虑会影响自主神经系统,导致心率和皮肤电活动加快。本文在对照试验中探索了机器学习方法来预测观看蜘蛛视频片段的蜘蛛恐惧个体的二级和三级焦虑。从心电图和皮肤电时间序列信号中提取特征。具体来说,本文探讨了随着训练集中与测试主题相关的数据量的增加,这些模型的性能。这里将标准的K-fold交叉验证与样本输入的泄漏组-fold交叉验证进行比较,其中我们系统地改变包括在训练集中的测试对象的样本数量。虽然二级和三级焦虑预测的k倍准确率可能分别达到78%和60%,但从训练集中排除所有测试对象数据会导致准确率下降到73%和45%。结果表明,这里使用的特征和模型不能泛化到跨主题分类任务中,在将主题数据分割为训练数据和测试数据时应该小心。此外,我们的研究结果解决了“冷启动问题”,提供了一个指示,在从生理数据中准确预测焦虑之前,需要从一个新的受试者那里获得多少数据。
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引用次数: 3
Multi-Gaussian Model for Estimating Stiffness Surrogate using Arterial Diameter Waveform 利用动脉直径波形估计刚度代理的多高斯模型
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478600
Rahul Manoj, V. RajKiran, P. Nabeel, M. Sivaprakasam, J. Joseph
Central Arteries’ elastic nature plays a fundamental role in maintaining cardiovascular health. Timely assessment of arterial stiffness helps in cardiovascular risk stratification. Various technological and methodological approaches exist to estimate arterial stiffness, through direct measurement of stiffness markers or surrogates. This work highlights a potential surrogate for arterial stiffness, based on the early onset of reflection waves. The significance comes with using low frame rate A-mode ultrasound scans for processing arterial diameter, modelled as a sum of three Gaussians. The novelty lies in the Gaussian modelled reflection onset time $left( {tau _R^{GM}} right)$, derived using the model parameters, a potential surrogate for early reflections and arterial stiffness. An observational cross-sectional study group of 34 subjects were recruited to validate this hypothesis. A statistically significant (p < 0.0001) correlation was obtained for $tau _R^{GM}$ against known stiffness markers. An R > 0.85 was obtained against Elastic modulus, specific stiffness index, and Pulse wave velocity. There exists an inverse correlation between the $tau _R^{GM}$ and popular stiffness markers. A statistically significant (p < 0.0001) correlation was obtained for $tau _R^{GM}$ against age, with R = 0.56. The early reflections were reliably detected by the $tau _R^{GM}$ and the evidenced strong correlation with stiffness markers make it a potential surrogate for arterial stiffness assessment. The advantage being that it can be obtained from a single pulse waveform like diameter.
中央动脉的弹性在维持心血管健康中起着重要作用。及时评估动脉僵硬度有助于心血管风险分层。通过直接测量硬度标记物或替代物,存在各种技术和方法方法来估计动脉硬度。这项工作强调了一种潜在的替代动脉僵硬,基于反射波的早期发作。这项研究的意义在于使用低帧率的a型超声扫描来处理动脉直径,并将其建模为三个高斯函数的和。新颖之处在于高斯建模的反射开始时间$left( {tau _R^{GM}} right)$,该时间使用模型参数推导而来,这是早期反射和动脉刚度的潜在替代品。一个由34名受试者组成的观察性横断面研究组被招募来验证这一假设。$tau _R^{GM}$与已知刚度指标的相关性具有统计学意义(p < 0.0001)。弹性模量、比刚度指数和脉冲波速的R > 0.85。$tau _R^{GM}$与常用刚度指标之间存在负相关关系。$tau _R^{GM}$与年龄的相关性有统计学意义(p < 0.0001), R = 0.56。通过$tau _R^{GM}$可靠地检测到早期反射,并且与硬度标记物的强相关性使其成为动脉硬度评估的潜在替代品。其优点是它可以像直径一样从单个脉冲波形中获得。
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引用次数: 0
Electronic Travel Aid for Visually Impaired People: Design and Experimental of a Special Antenna 视障人士电子旅行辅助设备:一种特殊天线的设计与实验
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478670
A. D. Leo, P. Russo, G. Cerri
In this paper a novel antenna for an electromagnetic assistance system for autonomous walking of blind or visually impaired people is presented. Its main aim is to detect obstacles that the white cane is not able to intercept, in particular those that can hurt the head or thorax zone. The proposed antenna has a fan beam radiation pattern, works at 24 GHz, in a frequency band reserved for ISM (Industrial, Scientific and Medical) applications. The antenna is designed using a numerical electromagnetic tool and its capability to detect a wide set of obstacles was investigated through numerical simulations and experimental measurements. Results confirm the good performances of the antenna and its capability to extend by a few meters the region usually explored by the white cane.
本文介绍了一种用于盲人或视障人士自主行走电磁辅助系统的新型天线。它的主要目的是检测白色手杖无法拦截的障碍物,特别是那些可能伤害头部或胸部的障碍物。该天线采用扇形波束辐射模式,工作频率为24ghz,为ISM(工业、科学和医疗)应用预留频段。采用数值电磁工具设计了天线,并通过数值模拟和实验测量研究了天线对多种障碍物的探测能力。结果表明,该天线具有良好的性能,能够将白手杖探测的区域扩展几米。
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引用次数: 0
期刊
2021 IEEE International Symposium on Medical Measurements and Applications (MeMeA)
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