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2021 IEEE International Symposium on Medical Measurements and Applications (MeMeA)最新文献

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Gait events detection from heel and toe trajectories: comparison of methods using multiple datasets 从脚跟和脚趾轨迹检测步态事件:使用多个数据集的方法比较
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478606
V. Guimarães, I. Sousa, M. Correia
Reliable detection of gait events is important to ensure accurate assessment of gait. While it is usually performed resorting to force platforms, methods based uniquely on kinematic analysis have also been proposed. These methods place no restrictions on the number of steps that can be analysed, simplifying setup and complexity of assessments. They also replace the need of annotating events manually when force platforms are not available. Although few methods have been proposed in literature, validation studies are relatively scarce. In this study we present multiple methods for the detection of heel strike (HS) and toe off (TO) in normal walking, and validate the detection against annotated events using three different datasets. The best performing candidates are based on the evaluation of heel vertical velocity (for HS) and toe vertical acceleration (for TO), resulting in relative errors of -12.4 ± 32.9 ms for HS and of -15.5 ± 24.9 ms for TO. The method is compatible with barefoot and shod walking, constituting a convenient, fast and reliable alternative to automatic gait event detection using kinematic data.
步态事件的可靠检测对于确保步态的准确评估至关重要。虽然通常是借助力平台进行的,但也提出了基于运动学分析的独特方法。这些方法对可以分析的步骤数量没有限制,简化了评估的设置和复杂性。当强制平台不可用时,它们还取代了手动注释事件的需要。虽然文献中提出的方法很少,但验证性研究相对较少。在这项研究中,我们提出了多种检测正常行走中脚跟撞击(HS)和脚趾脱落(TO)的方法,并使用三个不同的数据集验证了针对注释事件的检测。最佳候选鞋是基于对鞋跟垂直速度(HS)和脚趾垂直加速度(TO)的评估,HS和TO的相对误差分别为-12.4±32.9 ms和-15.5±24.9 ms。该方法兼容赤脚和穿鞋行走,是利用运动学数据自动检测步态事件的一种方便、快速、可靠的替代方法。
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引用次数: 3
Optimization of Blood Microfluidic Co-Flow Devices for Dual Measurement 双测量血液微流控共流装置的优化
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478718
Amit Nayak, C. Armstrong, C. Mavriplis, M. Fenech
Microfluidics is a prominent field used to analyze small amounts of biological fluids. Co-Flow microfluidic devices can be used to study red blood cell aggregation in blood samples under a controlled shear rate. The purpose of this paper is to optimize the parameters of a co-flow device in order to produce a linear velocity profile in blood samples which would provide a constant shear rate. This is desired as the eventual goal is to use an ultrasonic measurement sensor with the co-flow microfluidic device to analyze red blood cell aggregates. Computational fluid dynamic simulations were performed to model a microfluidic device. The simulation results were verified by µPIV of the experimental microfluidic device. Modifications were made to the geometry and flow rate ratio of the microfluidic device to produce a more linear velocity profile. By using a flow rate ratio of 50:1 of shearing fluid to sheared fluid, we were able to achieve a velocity profile in the blood layer that is approximately linear.
微流体学是用于分析少量生物流体的一个重要领域。共流微流控装置可用于研究受控剪切速率下血液样品中的红细胞聚集。本文的目的是优化共流装置的参数,以便在血液样品中产生线性速度剖面,从而提供恒定的剪切速率。这是理想的,因为最终的目标是使用超声测量传感器与共流微流体装置来分析红细胞聚集体。对微流控装置进行了计算流体动力学模拟。通过实验微流控装置的µPIV对仿真结果进行了验证。对微流控装置的几何形状和流量比进行了修改,以产生更线性的速度分布。通过使用50:1的剪切流体与剪切流体的流速比,我们能够在血液层中获得近似线性的速度分布。
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引用次数: 0
Effect of Deep Brain Stimulation Frequency on Gait Symmetry, Smoothness and Variability using IMU 脑深部电刺激频率对IMU步态对称性、平稳性和变异性的影响
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478602
E. Panero, E. Digo, U. Dimanico, C. Artusi, M. Zibetti, L. Gastaldi
Deep brain stimulation (DBS) implant represents an appropriate treatment for motor symptoms typical of Parkinson’s Disease (PD). However, little attention has been given to the effects of different DBS stimulation frequencies on gait outcomes. Accordingly, the aim of this pilot study was to evaluate the effects of two different DBS stimulation frequencies (60 and 130 Hz) on gait spatio-temporal parameters, symmetry, smoothness, and variability in PD patients. The analysis concentrated on acceleration signals acquired by a magnetic inertial measurement unit placed on the trunk of participants. Sessions of gait were registered for three PD patients, three young and three elderly healthy subjects. Gait outcomes revealed a connection with both age and pathology. Values of the Harmonic Ratio (HR) estimated for the three-axis acceleration signals showed subjective effects provoked by DBS stimulation frequencies. Consequently, HR turned out to be suitable for depicting gait characteristics, but also as a monitoring parameter for the subjective adaptation of DBS stimulation frequency. Concerning the Poincaré analysis of vertical acceleration signal, PD patients showed a greater dispersion of data compared to healthy subjects, but with negligible differences between the two stimulation frequencies. Overall, the presented analysis represented a starting point for the objective evaluation of gait performance and characteristics in PD patients with a DBS implant.
脑深部刺激(DBS)植入物是治疗帕金森病(PD)典型运动症状的合适方法。然而,很少有人关注不同DBS刺激频率对步态结果的影响。因此,本初步研究的目的是评估两种不同DBS刺激频率(60和130 Hz)对PD患者步态时空参数、对称性、平滑性和变异性的影响。分析集中在由放置在参与者躯干上的磁惯性测量单元获得的加速度信号上。对3名PD患者、3名年轻健康受试者和3名老年健康受试者进行步态记录。步态结果显示与年龄和病理有关。三轴加速度信号的谐波比(HR)值显示了DBS刺激频率引起的主观效应。因此,HR不仅适合描述步态特征,而且可以作为DBS刺激频率主观适应的监测参数。在poincar垂直加速信号分析中,PD患者与健康受试者相比,数据的分散性更大,但两种刺激频率之间的差异可以忽略不计。总的来说,所提出的分析为客观评估植入DBS的PD患者的步态表现和特征提供了一个起点。
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引用次数: 6
Metrological characterization and signal processing of a wearable sensor for the measurement of heart rate variability 用于测量心率变异性的可穿戴传感器的计量特性和信号处理
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478713
N. Morresi, S. Casaccia, G. M. Revel
This paper presents a methodology for the processing of the Photoplethysmography (PPG) signal measured using a smartwatch during motion tests. For statistical validation, signals from 15 healthy subjects have been collected while the subjects are walking on a treadmill. The motion artifacts (MAs) of the PPG signal have been removed demonstrating that the 37% of the signals are affected by MAs. Then, the experimental performance assessment of the PPG signal, from which the heart rate variability (HRV) has been extracted, by measuring the RR intervals, is compared to the RR intervals extracted from ECG signals measured using a multi-parametric chest belt that is considered as a reference sensor. The uncertainty of the PPG sensor in the measurement of the RR intervals is ± 169 ms, (with a coverage factor k = 2) if compared to the reference method, which in percentage is 30%.
本文提出了一种处理在运动测试中使用智能手表测量的光电体积脉搏波(PPG)信号的方法。为了统计验证,收集了15名健康受试者在跑步机上行走时的信号。PPG信号的运动伪影(MAs)被去除,表明37%的信号受到MAs的影响。然后,通过测量RR区间对提取心率变异性(HRV)的PPG信号进行实验性能评估,并将其与使用多参数胸带作为参考传感器从心电信号中提取的RR区间进行比较。与参考方法(占30%)相比,PPG传感器测量RR区间的不确定度为±169 ms(覆盖系数k = 2)。
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引用次数: 5
Comparison of different similarity measures in hierarchical clustering 层次聚类中不同相似性度量的比较
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478746
M. Vagni, N. Giordano, G. Balestra, S. Rosati
The management of datasets containing heterogeneous types of data is a crucial point in the context of precision medicine, where genetic, environmental, and life-style information of each individual has to be analyzed simultaneously. Clustering represents a powerful method, used in data mining, for extracting new useful knowledge from unlabeled datasets. Clustering methods are essentially distance-based, since they measure the similarity (or the distance) between two elements or one element and the cluster centroid. However, the selection of the distance metric is not a trivial task: it could influence the clustering results and, thus, the extracted information. In this study we analyze the impact of four similarity measures (Manhattan or L1 distance, Euclidean or L2 distance, Chebyshev or L∞ distance and Gower distance) on the clustering results obtained for datasets containing different types of variables. We applied hierarchical clustering combined with an automatic cut point selection method to six datasets publicly available on the UCI Repository. Four different clusterizations were obtained for every dataset (one for each distance) and were analyzed in terms of number of clusters, number of elements in each cluster, and cluster centroids. Our results showed that changing the distance metric produces substantial modifications in the obtained clusters. This behavior is particularly evident for datasets containing heterogeneous variables. Thus, the choice of the distance measure should not be done a-priori but evaluated according to the set of data to be analyzed and the task to be accomplished.
包含异构类型数据的数据集的管理是精准医学背景下的一个关键点,在精准医学背景下,每个人的遗传、环境和生活方式信息必须同时分析。聚类是一种强大的数据挖掘方法,用于从未标记的数据集中提取新的有用知识。聚类方法本质上是基于距离的,因为它们测量两个元素或一个元素与聚类质心之间的相似性(或距离)。然而,距离度量的选择并不是一项微不足道的任务:它可能会影响聚类结果,从而影响提取的信息。在本研究中,我们分析了四种相似性度量(曼哈顿或L1距离、欧几里得或L2距离、切比舍夫或L∞距离和高尔距离)对包含不同类型变量的数据集的聚类结果的影响。我们将分层聚类结合自动切点选择方法应用于UCI Repository上公开的六个数据集。对每个数据集进行了四种不同的聚类(每个距离一个),并从聚类数量、每个聚类中的元素数量和聚类质心三个方面进行了分析。我们的结果表明,改变距离度量会对获得的簇产生实质性的修改。这种行为对于包含异构变量的数据集尤其明显。因此,距离度量的选择不应是先验的,而应根据待分析的数据集和待完成的任务进行评估。
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引用次数: 2
Classification-based screening of Parkinson’s disease patients through voice signal 基于语音信号的帕金森病患者分类筛查
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478683
Fulvio Cordella, A. Paffi, A. Pallotti
In this paper a classification algorithm for Parkinson’s Disease screening is proposed. Code executes the processing of specific voice signals recorded by healthy and ill subjects. In the direction of a future implementation and validation in a home telemonitoring system, the algorithm has been built with the objective to serve as a screening tool for the precocious directing of subjects with high risk of neurological diseases to instrumental exams. In fact, in several neurological disorders, such as Parkinson’s disease, motor impairments of vocal apparatus arise earlier than postural and ambulatory symptoms. In a home telemonitoring system, in which hardware would consist in a voice recorder (that could be a simple smartphone) and a server for the web platform, data would be acquired and instantly stored on a platform for their processing through machine learning algorithms and to be viewed by specialists. For this purpose, a fully automatic process is needed. Therefore, in this work, audio-preprocessing and features computation are completely performed automatically, using Matlab. Final models have been trained in Matlab environments from Weka’s libraries. The family of developed models are trained with different type of phonations, from simple vowels to complex sounds, for a wider and more efficient analysis of vocal apparatus motor impairments. Moreover, dataset was 612 observation large, that is significantly above the mean size of similar works using simple phonations only. For a deeper analysis, different groups of parameters have been tested and cepstral features have been found to be optimal for classification and made up the big part of final algorithm. Developed models are part of the K-Nearest Neighbor family, thus, available for implementation in web platform. Finally, obtained models have shown high accuracies on the whole dataset, reaching values comparable with the literature but with more stability (standard deviation less than 1%). These results have been confirmed in the last validation session in which models have been exported and validated with 25% of data, reaching a best performance with a true positive rate of 98% and a true negative rate of 87%.
本文提出了一种用于帕金森病筛查的分类算法。代码执行对健康和患病受试者记录的特定语音信号的处理。为了在未来的家庭远程监控系统中实现和验证,该算法的目标是作为一种筛选工具,用于过早指导具有神经系统疾病高风险的受试者进行仪器检查。事实上,在一些神经系统疾病中,如帕金森氏病,发声器官的运动损伤比姿势和运动症状出现得更早。在家庭远程监控系统中,硬件将由录音机(可以是一个简单的智能手机)和网络平台的服务器组成,数据将被获取并立即存储在平台上,以便通过机器学习算法进行处理,并供专家查看。为此,需要一个全自动的过程。因此,在本工作中,音频预处理和特征计算完全是自动完成的,使用Matlab。最终的模型已经在来自Weka库的Matlab环境中进行了训练。该系列开发的模型使用不同类型的发音进行训练,从简单的元音到复杂的声音,以便更广泛、更有效地分析发声器官运动障碍。此外,数据集的大小为612个观测值,明显高于仅使用简单发音的同类作品的平均大小。为了进行更深入的分析,我们测试了不同的参数组,发现倒谱特征是最适合分类的,并构成了最终算法的大部分。开发的模型是k近邻系列的一部分,因此可以在web平台上实现。最后,获得的模型在整个数据集上显示出很高的精度,达到与文献相当的值,但具有更高的稳定性(标准差小于1%)。这些结果在最后一次验证会话中得到了证实,其中导出模型并使用25%的数据进行验证,达到了真阳性率为98%和真阴性率为87%的最佳性能。
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引用次数: 6
Image Quality Assessment for Endoscopy Applications 内窥镜应用的图像质量评估
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478603
R. Nishitha, Amalan Sebastin, Shubham Sharma, Ajay Kumar Gurrala, P. PreejithS., J. Joseph, M. Sivaprakasam
Assessment of image quality parameters in medical applications is crucial to produce high quality images that would significantly improve diagnoses and therapies. Solutions available in the market to assess the image quality provide experimental setups, standard test charts, and illumination setups. Parameters like sharpness, geometric distortion, and dynamic range require separate test charts and therefore can only be measured one at a time. In this paper, a single test chart to measure most of the image quality parameters has been described. A single image of this test chart could provide assessment of all the parameters considered. The size of the test chart could be customized according to the endoscopy application. An experimental setup was also designed in-house. This approach helped in developing a comprehensive and inexpensive assessment technique complying with the International Organization of Standardization (ISO) standards. Currently, the algorithms work with still images and could be extended to assess how the measured parameters would vary on a live video stream.
医学应用中图像质量参数的评估对于产生高质量的图像至关重要,这将显著改善诊断和治疗。市场上可用的评估图像质量的解决方案提供了实验设置、标准测试图表和照明设置。像清晰度、几何失真和动态范围这样的参数需要单独的测试图表,因此一次只能测量一个。在本文中,描述了一个单一的测试图来测量大多数图像质量参数。该测试图的单个图像可以提供所考虑的所有参数的评估。测试图的大小可以根据内窥镜的应用定制。内部还设计了一个实验装置。这种方法有助于开发一种符合国际标准化组织(ISO)标准的全面而廉价的评估技术。目前,该算法适用于静态图像,并可以扩展到评估实时视频流中测量参数的变化情况。
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引用次数: 4
An Efficient Near-lossless Compression Algorithm for Multichannel EEG signals 一种高效的多通道脑电信号近无损压缩算法
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478756
G. Campobello, Angelica Quercia, G. Gugliandolo, Antonino Segreto, E. Tatti, M. Ghilardi, G. Crupi, A. Quartarone, N. Donato
In many biomedical measurement procedures, it is important to record a huge amount of data, to monitor the state of health of a subject. In such a context, electroencephalograph (EEG) data are one of the most demanding in terms of size and signal behavior. In this paper, we propose a near-lossless compression algorithm for EEG signals able to achieve a compression ratio in the order of 10 with a root-mean-square distortion less than 0.01%. The proposed algorithm exploits the fact that Principal Component Analysis is usually performed on EEG signals for denoising and removing unwanted artifacts. In this particular context, we can consider this algorithm as a good tool to ensure the best information of the signal beside an efficient compression ratio, reducing the amount of memory necessary to record data.
在许多生物医学测量程序中,记录大量数据以监测受试者的健康状况是很重要的。在这种情况下,脑电图(EEG)数据在大小和信号行为方面是最苛刻的。在本文中,我们提出了一种脑电图信号的近无损压缩算法,能够实现10数量级的压缩比,均方根失真小于0.01%。该算法利用了通常对脑电信号进行主成分分析的事实来去噪和去除不需要的伪影。在这种特殊情况下,我们可以认为该算法是一个很好的工具,可以确保信号的最佳信息,以及有效的压缩比,减少记录数据所需的内存量。
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引用次数: 4
The capabilities of bioelectrical impedance body composition monitors in determining metabolic parameters during body shaping 生物电阻抗身体成分监测仪在身体塑形过程中测定代谢参数的能力
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478755
N. I. Khramtsova, S. Plaksin, D. N. Ponomarev, A. Sotskov
Body composition is closely related to the metabolic and biological functions of the body. Body composition and metabolic parameters were determined in 48 healthy women without an obesity, which underwent body shaping procedure – liposuction, with a usage of two types of body composition monitors.After liposuction, body weight significantly increased on average by 0.5 - 1.0 kg (p = 0.001). Body weight and body mass index correlated with all metabolic parameters.Body type was automatically calculated by "Tanita BC-542". Determination of body type when using "Tanita BC-601" was done manually. More than half of the patients on admission had a standard body type ("5" type) - 20 (54%), in 15 (41%) "hidden obesity" was found. After liposuction, 4 (14%) women improved their body type.The level of basal metabolic rate (BMR) in patients initially averaged 1340 ± 96 kcal when measured using a two-electrode analyzer, and 2128 ± 81 kcal - using a four-electrode analyzer (p = 0.0001), according to the literature – about 1000-1200 kcal. The average increase in BMR immediately after liposuction was 21 kcal, on the 7th day - 32 kcal.The metabolic age after body contouring became less than the actual one in 10 (56%) patients, by an average of 3.1 years (p = 0.0007).Four-electrode monitor revealed that an average decrease of fat on the abdomen was 5.4%. However, a decrease in its content in the hands and legs (in those zones that remained intact) was also detected. The analyzer also determined an increase in the content of muscles on the abdomen.In general, the bioelectrical impedance measurement in analysis of metabolic parameters in dynamics is simple and accessible, it has also a clinical importance. However, due to the identification of some errors, it requires repeated measurements and further improvement.
机体成分与机体的代谢和生物功能密切相关。对48名没有肥胖的健康女性进行了身体塑形手术——抽脂,并使用两种类型的身体成分监测仪,测定了她们的身体成分和代谢参数。吸脂后体重平均增加0.5 ~ 1.0 kg (p = 0.001)。体重和体质指数与所有代谢参数相关。体型由“Tanita BC-542”自动计算。使用“Tanita BC-601”时,机体类型的确定是手工完成的。超过一半的入院患者具有标准体型(“5”型)- 20 (54%),15 (41%)“隐性肥胖”被发现。抽脂后,4名(14%)女性的体型得到改善。水平的基础代谢率(BMR)最初的病人平均1340±96千卡使用二电极测量分析仪时,使用四电极和2128±81千卡,分析仪(p = 0.0001),根据文献——大约1000 - 1200千卡。平均抽脂后立即增加基础代谢率是21千卡,7天——32岁kcal.The代谢后的身体轮廓变得比实际的少10个(56%)病人,平均3.1年(p = 0.0007)。四电极监测显示腹部脂肪平均减少5.4%。然而,手和腿(在那些完好无损的区域)的含量也有所减少。分析仪还测定了腹部肌肉含量的增加。总的来说,生物电阻抗测量在动态代谢参数分析中简单易行,具有临床应用价值。但由于存在一些误差,需要反复测量和进一步改进。
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引用次数: 0
Unobtrusively Detecting Apnea and Hypopnea Events via a Hydraulic Bed Sensor 通过液压床传感器不显眼地检测呼吸暂停和呼吸不足事件
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478677
D. Heise, Ruhan Yi, Laurel A. Despins
Disordered breathing during sleep impacts sleep quality and the perceived amount of rest obtained while also serving as a potential indicator of other health conditions or risks. Apneas and hypopneas are leading indicators of disordered breathing, often quantified by an apnea-hypopnea index (AHI). Polysomnography is the gold standard for detecting apnea and hypopnea events (and thus calculating a subject’s AHI), but despite the inconvenience of sleeping in a strange place with numerous instruments attached, polysomnography delivers only a snapshot in time and is not practical for long-term monitoring. In this work, we describe a method of detecting apnea and hypopnea events during sleep using a hydraulic bed sensor, which has proven valuable for other dimensions of long-term monitoring and early detection of illness. We compare our results to those produced by a polysomnography lab, including calculation of respiratory disturbance indices. We successfully detect 73.6% of apneas with 77.2% precision, and our calculations for apnea index (AI) and respiratory disturbance index (RDI) are precise enough to indicate the appropriate severity of sleep apnea-hypopnea syndrome (SAHS) for each of our subjects.
睡眠时呼吸紊乱会影响睡眠质量和获得的休息时间,同时也是其他健康状况或风险的潜在指标。呼吸暂停和呼吸不足是呼吸障碍的主要指标,通常用呼吸暂停-呼吸不足指数(AHI)来量化。多导睡眠图是检测呼吸暂停和呼吸不足事件(从而计算受试者的AHI)的金标准,但尽管在一个陌生的地方睡觉会带来许多仪器的不便,但多导睡眠图只能及时提供快照,对于长期监测并不实用。在这项工作中,我们描述了一种使用液压床传感器检测睡眠期间呼吸暂停和呼吸不足事件的方法,该方法已被证明对长期监测和早期发现疾病的其他方面有价值。我们将结果与多导睡眠描记实验室产生的结果进行比较,包括呼吸障碍指数的计算。我们成功检测了73.6%的呼吸暂停,准确率为77.2%,我们对呼吸暂停指数(AI)和呼吸障碍指数(RDI)的计算足够精确,足以表明每个受试者的睡眠呼吸暂停低通气综合征(SAHS)的适当严重程度。
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引用次数: 4
期刊
2021 IEEE International Symposium on Medical Measurements and Applications (MeMeA)
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