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2021 IEEE International Symposium on Medical Measurements and Applications (MeMeA)最新文献

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Distinguishing Stroke patients with and without Unilateral Spatial Neglect by means of Clinical Features: a Tree-based Machine Learning Approach 通过临床特征来区分卒中患者单侧空间忽视:基于树的机器学习方法
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478727
L. Donisi, P. Moretta, A. Coccia, F. Amitrano, A. Biancardi, G. D'Addio
Unilateral Spatial Neglect is a cognitive impairment of neuropsychological interest that is a consequence of stroke able to influence negatively the rehabilitation outcome of patients with stroke. The aim of the study is to explore the feasibility of machine learning to classify stroke patients with and without unilateral spatial neglect using clinical features. We performed the study using a machine learning approach by means the following tree-based algorithms: Decision Tree, Random Forest, Rotation Forest, AdaBoost of decision stumps and Gradient Boost tree using six clinical features both numerical and nominal: Montreal Cognitive Assessment, Functional Independence Measure scale, Barthel Index, aetiology, site of brain lesion and presence of hemiparesis at lower limbs. Tree-based Machine learning analysis achieved interesting results in terms of evaluation metrics scores; the best algorithm was Random Forest with an Accuracy, Sensitivity, Specificity, Precision and Area under the Receiver Operating Characteristic curve equal to 0.92, 0.83, 1.00, 1.00, 0.95 respectively. The study demonstrated the proposed combination of clinical features and algorithms represents a valuable approach to automatically classify stroke patients with and without Unilateral Spatial Neglect. The future investigations on enriched datasets will further confirm the potential application of this methodology as prognostic support to be chosen among those already implemented in the clinical field.
单侧空间忽视是一种神经心理学的认知障碍,是中风的后果,能够对中风患者的康复结果产生负面影响。该研究的目的是探索机器学习的可行性,以分类卒中患者单侧空间忽视和不使用临床特征。我们使用机器学习方法通过以下基于树的算法进行研究:决策树、随机森林、旋转森林、AdaBoost决策树桩和梯度Boost树,使用六个数值和名义临床特征:蒙特利尔认知评估、功能独立测量量表、Barthel指数、病因学、脑损伤部位和下肢偏瘫的存在。基于树的机器学习分析在评估指标得分方面取得了有趣的结果;最佳算法为Random Forest,其准确率为0.92,灵敏度为0.83,特异性为1.00,精密度为1.00,接受者工作特征曲线下面积为0.95。该研究表明,临床特征和算法的结合代表了一种有价值的方法来自动分类卒中患者有无单侧空间忽视。未来对丰富数据集的调查将进一步证实该方法作为预后支持的潜在应用,可在临床领域中选择已实施的方法。
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引用次数: 10
Enhancing the Fluorescence and Cycle Threshold of qPCR Devices Through Excitation Time Point Adjustment 通过调节激发时间点提高qPCR装置的荧光和周期阈值
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478777
H. Tsai, L. Chao, Cheng-Ru Li, Kuo-Cheng Huang, Yu-Hsuan Lin, D. Shieh
Quantitative polymerase chain reaction (qPCR) has been widely employed for the positive or negative detection of bacteria or viruses, particularly SARS-CoV-2. Fluorescence signal and cycle threshold information is critical for the positive and negative detection of target test samples in qPCR systems. To determine viral concentration, the fluorescence intensity of each cycle must be recorded using a qPCR system. In general, the time points of fluorescence excitation and excitation light intensity affect fluorescence intensity. Thus, this study proposed an effective excitation method for enhancing fluorescence intensity. Several parameters, including excitation light intensity, the excitation time point, and the reaction time of the reagent at each temperature stage, were modified in assessing fluorescence performance and determining suitable parameters for fluorescence excitation in a qPCR system. Fluorescence intensity resulted in the most optimal fluorescence performance; specifically, excitation was triggered by using a 30 mA current, and the excitation light was activated when the temperature decreased to 60 °C. Total reaction time was 1 s, and the concentrated fluorescence value and suitable cycle threshold value were obtained. Overall, high efficiency, low fluorescence decay, and high light stability were observed. The present findings demonstrate that controlling the time point of excitation light can enhance the fluorescence efficiency and performance of qPCR systems, with relevant benefits in medical diagnostics and rapid viral detection, among other applications.
定量聚合酶链反应(qPCR)已广泛用于细菌或病毒的阳性或阴性检测,特别是SARS-CoV-2。在qPCR系统中,荧光信号和周期阈值信息对目标检测样品的阳性和阴性检测至关重要。为了确定病毒浓度,必须使用qPCR系统记录每个周期的荧光强度。一般来说,荧光激发的时间点和激发光强都会影响荧光强度。因此,本研究提出了一种有效的增强荧光强度的激发方法。在qPCR系统中,对激发光强度、激发时间点和试剂在每个温度阶段的反应时间等几个参数进行了修改,以评估荧光性能并确定合适的荧光激发参数。荧光强度导致荧光性能最优;具体来说,用30ma电流触发激发,当温度降至60℃时激活激发光。总反应时间为1 s,得到了浓缩荧光值和合适的循环阈值。总体而言,观察到高效率、低荧光衰减和高光稳定性。本研究结果表明,控制激发光的时间点可以提高qPCR系统的荧光效率和性能,在医学诊断和快速病毒检测等应用中具有相关益处。
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引用次数: 0
Multiple Input, Single Output Frequency Mixing Communication Technique for Low Power Data Transmission 用于低功率数据传输的多输入单输出混频通信技术
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478708
Giuliana Emmolo, Daryl Ma, Danilo Demarchi, P. Georgiou
The paradigm of Internet of Things (IoT) has revolutionised the field of human health monitoring. Recent research works outline an ever growing interest in the development of miniaturized fully functioning devices, where optimization strategies in terms of size, power consumption and data transmission capabilities represents the main requirements as well as the biggest challenges at the design stage. In this paper we provide an analysis into a data transmission method based on digital mixing for combining multiple inputs channels into a single output. We first demonstrate that the sources of the error generated in the output stream are the frequency ratio of the input signals and their relative phase shift. With the results from the simulations, we demonstrate that the error performed on the lower frequency information in the mixed signal has a trend which is exponentially decreasing with the input frequency ratio. Additionally, we prove that the relative phase shift of the input signals may significantly impact the error towards lower input frequency ratios. Afterwards, we analyze the system power consumption, and we demonstrate that the power trend is linear with the input frequency ratio. Lastly, we discuss the error performance versus power trade-off of the system, which is helpful for the design of the input frequency levels for a specific target application.
物联网(IoT)范式彻底改变了人类健康监测领域。最近的研究工作概述了对小型化全功能设备开发的日益增长的兴趣,其中在尺寸,功耗和数据传输能力方面的优化策略代表了设计阶段的主要要求和最大挑战。本文分析了一种基于数字混频的数据传输方法,将多个输入通道合并为一个输出通道。我们首先证明了输出流中产生的误差的来源是输入信号的频率比和它们的相对相移。仿真结果表明,混合信号中低频信息的误差随输入频率比的增大呈指数减小的趋势。此外,我们证明了输入信号的相对相移可能会显著影响较低输入频率比的误差。然后,我们分析了系统功耗,并证明了功率趋势与输入频率比呈线性关系。最后,我们讨论了系统的误差性能与功率权衡,这有助于设计特定目标应用的输入频率电平。
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引用次数: 0
Data-driven Development of Digital Health Applications on the Example of Dementia Screening 以痴呆症筛查为例的数据驱动的数字健康应用开发
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478676
Markus Schinle, Christina Erler, Timon Schneider, Joana Plewnia, Wilhelm Stork
Following the paradigm of precision medicine, the combination of health data and Machine Learning (ML) is promising to improve the quality of healthcare services e.g. by making diagnoses and therapeutic interventions as early and precise as possible. The implementation of this approach requires sufficient amounts of data with a high quality along the data life cycle. This goal seems recently achievable through the implementation of several national digital health strategies and the hope of a growing societal acceptance of digital health applications due to the implications of the COVID-19 pandemic. But, a collection of tools and methods is missing, which supports developers to use data as driving force of the development process. Due to the iterative nature of software application development, it allows the continuous improvement through the integration of collected digital data. We refer to this as a data-driven approach and identify steps to take and tools for its implementation. Associated challenges and opportunities of this translational approach are outlined on the example of a self-developed dementia screening application. Using our methodology, we compared multiple ML algorithms based on the data of an observational study (n=55) and achieved models with sensitivity up to 89% for unhealthy participants within this use case.
遵循精准医疗的范例,健康数据和机器学习(ML)的结合有望提高医疗服务的质量,例如通过尽可能早和准确地进行诊断和治疗干预。这种方法的实现需要在整个数据生命周期中有足够数量的高质量数据。最近,通过实施若干国家数字卫生战略,以及由于COVID-19大流行的影响,数字卫生应用有望得到越来越多的社会接受,这一目标似乎可以实现。但是,缺少一组工具和方法来支持开发人员使用数据作为开发过程的驱动力。由于软件应用程序开发的迭代性质,它允许通过集成收集的数字数据进行持续改进。我们将其称为数据驱动的方法,并确定要采取的步骤和实现该方法的工具。相关的挑战和机遇,这种转化方法概述了一个例子,自行开发的痴呆症筛查应用。使用我们的方法,我们基于一项观察性研究(n=55)的数据比较了多种ML算法,并在该用例中获得了对不健康参与者灵敏度高达89%的模型。
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引用次数: 3
Reducing effect of magnetic field noise on sensor position estimation in surgical EM tracking 降低手术电磁跟踪中磁场噪声对传感器位置估计的影响
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478723
M. Ragolia, F. Attivissimo, A. Nisio, A. Lanzolla, M. Scarpetta
Surgery navigation techniques aim to support surgeons during operations, resulting in improved accuracy and patient safety. In this context, electromagnetic tracking systems (EMTSs) are mainly used since they enable real-time tracking of small EM sensors included in surgical tools without line-of-sight restrictions. On the other hand, these systems are very sensible to magnetic field variations that can affect sensor position estimation performance. In this paper we analyze how magnetic field variations caused by the noise of transmitting coils’ excitation currents affect system performance, and we propose a technique to reduce its undesirable effect. This method includes, in the position estimation algorithm, the measurement of excitation currents, thus compensating errors in sensor signal caused by current noise.Different simulation tests were performed to assess the proposed method which is based on modeling the magnetic field produced by the field generator (FG). Finally, it is validated by using experimental data provided by a novel EMTS prototype, obtaining noise peaks reduction and an overall mean position error of 3 mm at a distance of 600 mm from the FG.
手术导航技术的目的是在手术过程中支持外科医生,从而提高准确性和患者安全性。在这种情况下,主要使用电磁跟踪系统(emts),因为它们可以实时跟踪手术工具中包含的小型电磁传感器,而不受视线限制。另一方面,这些系统对磁场变化非常敏感,磁场变化会影响传感器的位置估计性能。本文分析了由发射线圈励磁电流噪声引起的磁场变化对系统性能的影响,并提出了一种减小其不良影响的技术。该方法在位置估计算法中包括对励磁电流的测量,从而补偿电流噪声对传感器信号造成的误差。对磁场发生器产生的磁场进行了建模,并进行了不同的仿真试验来评估所提出的方法。最后,利用新型EMTS样机提供的实验数据进行验证,在距离FG 600 mm处,噪声峰值降低,总体平均位置误差为3 mm。
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引用次数: 4
Application of Hybrid Network of UNet and Feature Pyramid Network in Spine Segmentation UNet混合网络与特征金字塔网络在脊柱分割中的应用
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478765
Xingxing Liu, Wenxiang Deng, Yang Liu
Spine segmentation is a common task for spinal imaging and spinal surgical navigation. Spine segmentation provides valuable information for the diagnosis, and the segmentation output can also serve as an input for downstream surgical navigation. Unfortunately, spine segmentation is a labor-intensive task. In this study, we applied a deep network combining feature pyramid network (FPN) and UNet to the segmentation of vertebral bodies (VBs), referring as Res50_UNet. Compared with the original UNet, Res50_UNet has the following enhancements: 1) five consecutive spine MRI slices and two coordinate maps are concatenated as the input; 2) the convolutional block from ResNet are used; 3) an FPN architecture is applied to extracting rich multi-scale features and obtaining segmentation output. Experiments were conducted on an annotated T2-weighted MRIs of the lower spine dataset. We have benchmarked Res50_UNet against UNet and other UNet based network structures. It was found that Res50_UNet needs the lowest number of epochs (~1000 epochs) to achieve steady-state performance. The accuracy (AC) of Res50_UNet is higher than 99.5% with only 1000 epochs, which is very impressive. This study demonstrated the feasibility of applying Res50_UNet in spine segmentation. The network integrates the characteristics of FPN and UNet. These results have shown the potential for Res50_UNet in spine MRI segmentation, especially when a low number of epochs is desirable.
脊柱分割是脊柱成像和脊柱外科导航的常见任务。脊柱分割为诊断提供了有价值的信息,分割输出也可以作为下游手术导航的输入。不幸的是,脊柱分割是一项劳动密集型的任务。在本研究中,我们将特征金字塔网络(FPN)和UNet相结合的深度网络用于椎体(VBs)的分割,称为Res50_UNet。与原始UNet相比,Res50_UNet有以下增强:1)将5张连续的脊柱MRI切片和2张坐标图连接起来作为输入;2)使用来自ResNet的卷积块;3)采用FPN架构提取丰富的多尺度特征,获得分割输出。实验是在腰椎数据集的带注释的t2加权mri上进行的。我们对Res50_UNet和其他基于UNet的网络结构进行了基准测试。结果表明,Res50_UNet需要最少的epoch数(~1000 epoch)才能达到稳态性能。Res50_UNet的准确率(AC)在1000个epoch的情况下就超过了99.5%,这是非常令人印象深刻的。本研究证明了Res50_UNet应用于脊柱分割的可行性。该网络融合了FPN和UNet的特点。这些结果显示了Res50_UNet在脊柱MRI分割中的潜力,特别是当需要低epoch数时。
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引用次数: 1
Using Zigbee Sensors for Ambient Measurement of Human Gait – Analytical Considerations 使用Zigbee传感器进行人体步态的环境测量-分析考虑
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478695
Ashi Agarwal, Bruce Wallace, L. Ault, J. Larivière-Chartier, F. Knoefel, R. Goubran, J. Kaye, Z. Beattie, N. Thomas
With the aging of the population in Canada and elsewhere, applications of Smart Homes for well-being sensing are increasingly being considered in health care. Many of these smart home networks rely on the Zigbee wireless protocol to connect sensors used to measure various health outcomes. This paper provides preliminary results of gait estimation performed on 3 different residences over 11 months using Zigbee connected motion sensors, with a focus on understanding accuracy limitations induced by the Zigbee communication protocol. The accuracy limitations were also observed in the results from a controlled experiment done with 2 different sets of Zigbee motion sensors. This paper provides an in-depth analysis on root cause of variance in gait estimation at the same time laying out conservative variance estimations caused by different scenarios. The accuracy considerations highlighted by the paper are also applicable for all other time sensitive measures. Results of this paper necessitate further analysis of the use of Zigbee operated sensor networks in the evaluation of time sensitive measures.
随着加拿大和其他地方的人口老龄化,越来越多的人在医疗保健中考虑使用智能家居来感知福祉。许多智能家庭网络依赖Zigbee无线协议连接用于测量各种健康结果的传感器。本文提供了使用Zigbee连接的运动传感器在11个月内对3个不同住宅进行步态估计的初步结果,重点是了解Zigbee通信协议引起的准确性限制。在使用两组不同的Zigbee运动传感器进行的对照实验结果中也观察到精度限制。本文深入分析了步态估计中方差的根本原因,同时给出了不同场景下的保守方差估计。本文强调的准确性考虑也适用于所有其他时间敏感的测量。本文的结果需要进一步分析Zigbee操作的传感器网络在时间敏感措施评估中的应用。
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引用次数: 4
The use of cognitive training and tDCS for the treatment of an high potential subject: a case study 运用认知训练和tDCS治疗高潜能受试者:个案研究
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478697
Roberta Renati, N. S. Bonfiglio, Ludovica Patrone, D. Rollo, M. P. Penna
Scientific literature has shown how people with ADHD, subjects with High Potential, and with High Levels of Creativity share the same behavioral and cognitive patterns, especially related to some aspects associated with executive functions, such as attentional disorders, impulsivity, and inhibitory control deficit. Several studies have shown how it is possible to improve executive functions by regulating the neuronal activity of the Prefrontal Area. Other researches have obtained equally interesting results through the use of cognitive training and video games, as well as the aim of motivating children and adolescents. This paper presents a clinical case of a high potential adolescent treated through the use of cognitive training with tDCS. The treatment consisted of the use of tDCS associated with cognitive training for 12 sessions. Cognitive battery before starting treatment and at the end of treatment, and trials on executive functions before and after each training session, where administered. The results show an improvement in the cognitive battery and the trials of executive functions, especially in the second part of the training. The results obtained in this work demonstrate how the use of training, associated with tDCS neurostimulation, represents a useful and functional treatment for people with High Potential. The protocol proposed here also lies in the possibility of being used remotely and without the presence of the operators, overcoming the limits of traditional methods.
科学文献表明,患有多动症的人、具有高潜力的人以及具有高水平创造力的人有着相同的行为和认知模式,特别是在与执行功能相关的某些方面,如注意力障碍、冲动和抑制控制缺陷。几项研究表明,如何通过调节前额叶区域的神经元活动来改善执行功能是可能的。其他研究通过使用认知训练和电子游戏,以及激励儿童和青少年的目的,获得了同样有趣的结果。本文介绍了一个高潜力青少年通过使用认知训练与tDCS治疗的临床病例。治疗包括使用tDCS与认知训练相结合的12个疗程。治疗开始前和治疗结束时的认知能力测试,以及每次训练前后的执行功能测试。结果表明,在认知电池和执行功能的试验中,特别是在训练的第二部分,认知电池和执行功能得到了改善。在这项工作中获得的结果表明,如何使用与tDCS神经刺激相关的训练,对高潜力人群来说是一种有用和功能性的治疗方法。本文提出的协议还在于可以在没有操作员在场的情况下远程使用,克服了传统方法的局限性。
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引用次数: 4
A Wearable SSVEP BCI for AR-based, Real-time Monitoring Applications 基于ar的实时监控应用的可穿戴SSVEP BCI
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478593
P. Arpaia, E. D. Benedetto, N. Donato, Luigi Duraccio, N. Moccaldi
A real-time monitoring system based on Augmented Reality (AR) and highly wearable Brain-Computer Interface (BCI) for hands-free visualization of patient’s health in Operating Room (OR) is proposed. The system is designed to allow the anesthetist to monitor hands-free and in real-time the patient’s vital signs collected from the electromedical equipment available in OR. After the analysis of the requirements in a typical Health 4.0 scenario, the conceptual design, implementation and experimental validation of the proposed system are described in detail. The effectiveness of the proposed AR-BCI-based real-time monitoring system was demonstrated through an experimental activity was carried out at the University Hospital Federico II (Naples, Italy), using operating room equipment.
提出了一种基于增强现实(AR)和高可穿戴脑机接口(BCI)的手术室患者健康可视化实时监控系统。该系统的设计目的是让麻醉师能够实时监控从手术室中可用的电子医疗设备收集的患者生命体征。在分析了典型健康4.0场景的需求后,详细描述了所提出系统的概念设计、实现和实验验证。在费德里科二世大学医院(意大利那不勒斯)使用手术室设备进行的实验活动证明了所提出的基于ar - bci的实时监测系统的有效性。
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引用次数: 6
Densely Connected Convolutional Networks (DenseNet) for Diagnosing Coronavirus Disease (COVID-19) from Chest X-ray Imaging 基于胸部x线影像诊断冠状病毒病(COVID-19)的密集连接卷积网络(DenseNet
Pub Date : 2021-06-23 DOI: 10.1109/MeMeA52024.2021.9478715
Hamed Tabrizchi, A. Mosavi, Z. Vámossy, A. Várkonyi-Kóczy
Since the beginning of the coronavirus disease (COVID-19) pandemic several machine learning and deep learning methods had been introduced to detect the infected patients using the X-Ray or CT scan images. Numerous sophisticated data-driven methods had been introduced to improve the performance and the accuracy of the diagnosis models. This paper proposes an improved densely connected convolutional networks (DenseNet) method based on transfer learning (TL) to enhance the model performance. The results show promising model accuracy.
自2019冠状病毒病(COVID-19)大流行开始以来,已经引入了几种机器学习和深度学习方法,通过x射线或CT扫描图像检测感染患者。为了提高诊断模型的性能和准确性,引入了许多复杂的数据驱动方法。为了提高模型的性能,提出了一种基于迁移学习(TL)的改进密集连接卷积网络(DenseNet)方法。结果表明,该模型具有良好的精度。
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引用次数: 8
期刊
2021 IEEE International Symposium on Medical Measurements and Applications (MeMeA)
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