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Eating disorders among professional athletes. A narrative review 职业运动员的饮食失调。叙述性综述
Pub Date : 2024-07-19 DOI: 10.12775/qs.2024.17.52963
Oliwia Szewczyk, Ewa Olek, Karolina Czarnecka, Anna Korczak, Katarzyna Burda, Emilia Wójcik, Olga Łopacińska, Katarzyna Stańczyk, Aleksandra Korn, Justyna Jędrzejczyk
Introduction: Eating disorders are potentially mortal health conditions affecting mostly young people. The reasons for that in general population are connected to  vulnerable self-image, following the current beauty standards and co-existing psychiatric comorbidities. Athletes may be in danger of developing a pathological eating pattern due to sport specific reasons such as higher scores related to thinner body. Aim of study: The main aim of the study was to examine the relationship between eating disorders in professional athletes’ population, evaluate causes and risk factors and to assess health consequences to eating disorder in sport. Materials and methods: This article is based on the literature found in PubMed and Google Scholar Database with the use of keywords such as ”eating disorders”, “sport”, “athletes”, “anorexia nervosa in athletes”, “eating disorders in sport”, “disordered eating in sportsmen”, “female athletes”, “bulimia nervosa”, “binge eating”, “ED and sport”, “mental health and sport”, “consequences of eating disorders”, “sport education”. Results: Investigation of available literature revealed the connection between developing eating disorder in professional athlete sample. The reasons behind it are mostly sports’ oriented and connected to the desire to achieve better results and perfectionism. However, developing an eating disorder results in worse sports’ performance, menstrual irregularity, lower bone mineral density, cardiovascular issues and can be potentially mortal. Conclusion: Athletes are in danger of developing eating disorders. There should be a focus on  evaluating people in sport in terms of eating patterns, however available questionnaires are inefficient because players tend to underreport their problems. Coaches and families of the athletes need to be educated in the topic as they can recognize dangerous behaviors first.  
导言饮食失调是一种潜在的致命健康问题,主要影响年轻人。在普通人群中,饮食失调的原因与脆弱的自我形象、追随当前的审美标准以及并存的精神疾病有关。由于运动的特殊原因,运动员可能会有形成病态饮食模式的危险,如较瘦的身体得分较高。研究目的:本研究的主要目的是研究职业运动员群体中饮食失调之间的关系,评估其原因和风险因素,并评估体育运动中饮食失调对健康造成的影响。材料和方法:本文基于在 PubMed 和谷歌学术数据库中找到的文献,使用的关键词包括 "饮食失调"、"体育"、"运动员"、"运动员厌食症"、"体育运动中的饮食失调"、"运动员饮食失调"、"女运动员"、"神经性贪食症"、"暴饮暴食"、"ED 与体育运动"、"心理健康与体育运动"、"饮食失调的后果"、"体育教育"。研究结果对现有文献的调查显示,专业运动员样本中出现饮食失调之间存在联系。其背后的原因大多以体育为导向,与取得更好成绩的愿望和完美主义有关。然而,饮食失调会导致运动成绩下降、月经不调、骨矿物质密度降低、心血管问题,甚至可能致命。结论运动员有患上饮食失调症的危险。应重视对体育运动中的饮食模式进行评估,但现有的调查问卷效率不高,因为运动员往往很少报告自己的问题。教练和运动员家属需要接受相关教育,因为他们可以首先识别危险行为。
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引用次数: 0
Is it possible to tame fear through sport? 有可能通过体育驯服恐惧吗?
Pub Date : 2024-07-19 DOI: 10.12775/qs.2024.17.53043
Małgorzata Miazga, Jagna Golemo, Barbara Serkis, Zuzanna Bentkowska, Aleksandra Bogoń, Magdalena Ostojska, Izabela Kałuża, Justyna Szpyra, Magdalena Celichowska, Magdalena Górska
Introduction: Fear of falling  is described as a natural response to unstable balance resulting problems with postural control. It usually occurs in older people suffering from chronic diseases and lowers their quality of life. Importantly, general physical activity is limited by the fear of falling, which makes everyday functioning difficult.  Aim of the study: The aim of this paper is to present and submit the latest discoveries regarding the topic of fear of falling and physical activity. Material and Methods: This article was created based on the PubMed and Scholar database.The literature was reviewed using the keywords: „fear of falling”; „physical activity”. Results: Research shows that there are many chronic diseases, for example diabetic neuropathy, Parkinson's disease or hip fractures, that may predispose patients to fear of falling. The Falls Efficacy Scale - International (FES-I) is one of the several tools to assess fear of falling, which facilitates the selection of appropriate care and interventions. Well-selected exercises such as the Otago programme, can be implemented to reduce this problem. Generally physical activity combined with the proper encouragement to exercise at home is highly effective in reducing the fear of falling.  Conclusion: Considering that more and more people may be exposed to the experience fear of falling it seems significant how to combat this problem. There are appropriate methods to assess and interventions which can be implemented to reduce fear of falling by clinicians, but further studies are still needed.
简介害怕跌倒是平衡不稳导致姿势控制问题的一种自然反应。它通常发生在患有慢性疾病的老年人身上,会降低他们的生活质量。重要的是,由于害怕跌倒,一般体力活动受到限制,从而使日常活动变得困难。 研究目的本文旨在介绍和提交有关跌倒恐惧与身体活动这一主题的最新发现。材料与方法:本文根据 PubMed 和 Scholar 数据库创建:关键词:"跌倒恐惧";"体育锻炼"。结果研究表明,许多慢性疾病,如糖尿病神经病变、帕金森病或髋部骨折等,都可能导致患者害怕跌倒。国际跌倒效能量表(FES-I)是评估跌倒恐惧的多种工具之一,有助于选择适当的护理和干预措施。精心选择的运动,如奥塔哥计划,可以减少这一问题。一般来说,体育锻炼加上适当鼓励在家中锻炼,对减少跌倒恐惧非常有效。 结论考虑到越来越多的人可能会有摔倒恐惧的经历,如何解决这一问题显得尤为重要。临床医生可以通过适当的评估方法和干预措施来减少跌倒恐惧,但仍需进一步研究。
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引用次数: 0
Non-operative methods for the treatment of female stress urinary incontinence 治疗女性压力性尿失禁的非手术方法
Pub Date : 2024-07-19 DOI: 10.12775/qs.2024.17.53058
Klara Wojciechowska, Monika Turek, Joanna Skotnicka, Aleksandra Jaroń, Katarzyna Jastrzębska, Karolina Piątkowska, Karolina Błaszczak, Maria Witkowska, Tymoteusz Ślósarz, Maciej Witkowski
Purpose of research: Stress urinary incontinence (SUI) is a common health problem, especially among women which impairs daily functioning. The purpose of this research is to elucidate the pathophysiology of stress urinary incontinence (SUI), describe its diagnostic methods, summarize current treatments in light of recent studies, and outline examples of new potential therapies. Methods: Databases such as PubMed, Medline, and ResearchGate were searched with particular attention to the current guidelines. Basic results: The primary treatment of SUI is lifestyle modification, including weight reduction. Pelvic floor muscle training (PFMT) is recommended as first-line therapy, reducing the number of incontinence episodes and improving quality of life.  Additional methods include electrical stimulation or biofeedback. At later stages of treatment, pharmacological therapy is recommended, mainly using vaginal oestrogens and duloxetine. Conclusions: Non-operative therapies, such as lifestyle modification and PFMT, are effective treatments for SUI. In combination with pharmacotherapy, they significantly improve the quality of life of patients without invasive surgical procedures.
研究目的:压力性尿失禁(SUI)是一种常见的健康问题,尤其是在妇女当中,它会影响日常功能。本研究旨在阐明压力性尿失禁(SUI)的病理生理学,描述其诊断方法,根据最新研究总结目前的治疗方法,并概述新的潜在疗法实例。方法:检索了 PubMed、Medline 和 ResearchGate 等数据库,并特别关注了现行指南。基本结果:SUI 的主要治疗方法是改变生活方式,包括减轻体重。建议将盆底肌肉训练(PFMT)作为一线疗法,以减少尿失禁发作次数并改善生活质量。 其他方法包括电刺激或生物反馈。在治疗的后期阶段,建议采用药物疗法,主要使用阴道雌激素和度洛西汀。结论非手术疗法,如改变生活方式和 PFMT,是治疗 SUI 的有效方法。它们与药物疗法相结合,可显著改善患者的生活质量,而无需进行侵入性手术。
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引用次数: 0
Treatment of COPD with a particular focus on biological therapy: a systematic review 以生物疗法为重点的慢性阻塞性肺病治疗:系统综述
Pub Date : 2024-07-19 DOI: 10.12775/qs.2024.17.53022
Kinga Ziojła-Lisowska, Agnieszka Kuzio, Aleksandra Cieplińska
Incroduction and aim. COPD is a heterogeneous condition characterized by persistent respiratory symptoms. These symptoms can significantly reduce the quality of life for patients. The conventional treatment used so far is not always effective, especially in cases of severe disease and in specific phenotypes, which is why researchers are constantly searching for new drugs. The aim of this paper is to review the published literature on the treatment of COPD, with particular emphasis on the role of biological therapy. Material and methods. Online databases were used for literature research. The review primarily included literature published after 2016. Analysis of the literature. Conventional pharmacological treatment for COPD patients mainly relies on the use of bronchodilators. Recently, researchers have increasingly focused on the potential use of biological therapy in COPD. The greatest hope lies in the broader use of biological therapy in patients with COPD with elevated eosinophil counts. One of the targets is the IL-33/ST2 pathway, which partially directs inflammatory and remodeling processes in COPD. Drugs belonging to this group include tozorakimab, itepekimab, and astegolimab. Another mechanism of action for biological drugs is blocking IL-5; drugs that work through this mechanism include mepolizumab and benralizumab. Dupilumab is a monoclonal antibody that, due to promising research results, currently has the greatest potential for expanding indications for the treatment of COPD. Conclusion. Since biological therapy offers hope for better disease control in specific groups of patients, further clinical research is necessary to explore the use of biological treatment. This could improve the quality of life for individuals with COPD, especially those who respond poorly to conventional treatment. Key words. COPD, chronic obstructive pulmonary disease, biology treatment
导言和目的。慢性阻塞性肺病是一种以持续呼吸道症状为特征的异质性疾病。这些症状会大大降低患者的生活质量。迄今为止所采用的常规治疗方法并不总是有效,尤其是在病情严重和有特定表型的情况下,这也是研究人员不断寻找新药的原因。本文旨在回顾已发表的有关慢性阻塞性肺病治疗的文献,特别强调生物疗法的作用。材料和方法。使用在线数据库进行文献研究。综述主要包括 2016 年之后发表的文献。文献分析。慢性阻塞性肺疾病患者的传统药物治疗主要依赖于支气管扩张剂的使用。最近,研究人员越来越关注生物疗法在慢性阻塞性肺病中的潜在应用。最大的希望在于对嗜酸性粒细胞计数升高的慢性阻塞性肺病患者更广泛地使用生物疗法。其中一个靶点是 IL-33/ST2 通路,该通路在一定程度上引导着慢性阻塞性肺病的炎症和重塑过程。这类药物包括托佐利单抗(tozorakimab)、伊替匹单抗(itepekimab)和阿斯替戈利单抗(astegolimab)。生物药物的另一种作用机制是阻断 IL-5;通过这种机制发挥作用的药物包括 mepolizumab 和 benralizumab。Dupilumab是一种单克隆抗体,由于研究结果令人鼓舞,目前最有可能扩大治疗慢性阻塞性肺病的适应症。结论由于生物疗法为特定患者群体提供了更好地控制疾病的希望,因此有必要进一步开展临床研究,探索生物疗法的应用。这可以提高慢性阻塞性肺病患者的生活质量,尤其是那些对常规治疗反应不佳的患者。关键词慢性阻塞性肺病、慢性阻塞性肺病、生物治疗
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引用次数: 0
Sport and type 1 diabetes - a great value but also a challenge. Review of the literature and guidelines 体育运动与 1 型糖尿病--具有重要价值,但也是一项挑战。文献和指南回顾
Pub Date : 2024-07-18 DOI: 10.12775/qs.2024.17.52978
Karolina Błaszczak, Adrian Kruszewski, Natalia Paduszyńska, Anna Dąbrowska, Paulina Przybysz, Monika Szyszka, Maja Kucharska
Introduction: Type 1 diabetes is a disease requiring complex treatment: intensive functional insulin therapy with multiple subcutaneous insulin injections (Multiple daily doses of insulin- MDI) or continuous subcutaneous insulin infusion (CSII) with a personal insulin pump. Type 1 diabetes is a disease with many complications including cardiovascular diseases. A key element in good disease control is adequate patient education. This paper will focus on physical activity and its impact on the course of the disease.   Aim of the study: To research the impact of physical activity on the course of type 1 diabetes. To reinforce medical professionals' knowledge of exercise management among patients with type 1 diabetes.   State of Knowledge: Regular physical exercise is beneficial for diabetes control, at the same time reducing the need for insulin. It also reduces the risk of dangerous late cardiovascular complications. Meta-analyses have shown a significant effect of physical activity on the reduction of HbA1c, BMI, triglycerides and total cholesterol. Continuous glucose monitoring (CGM) systems are recommended for physically active people with type 1 diabetes. Optimal glycaemia at the start and during sport are: for aerobic exercise 126-180 mg/dl (7-10 mmol/l), for anaerobic exercise 90-180 mg/dl (5-10 mmol/l). The reduction in insulin dose depends on the type of exercise, the length of the exercise, the method of treatment, and the pre-exercise blood glucose level.   Conclusion: Physical exercise improves the control of type 1 diabetes and therefore reduces the risk of complications of the disease including cardiovascular diseases. Type 1 diabetes is not a contraindication to both amateur and professional sport. However, many variables need to be considered. Every patient with type 1 diabetes must be properly trained before starting exercise.
导言:1 型糖尿病是一种需要复杂治疗的疾病:通过多次皮下注射胰岛素(每日多剂量胰岛素-MDI)或使用个人胰岛素泵持续皮下注射胰岛素(CSII)进行强化功能性胰岛素治疗。1 型糖尿病有许多并发症,包括心血管疾病。良好的疾病控制的关键因素是对患者进行充分的教育。本文将重点讨论体育锻炼及其对疾病进程的影响。 研究目的研究体育锻炼对 1 型糖尿病病程的影响。加强医务人员对 1 型糖尿病患者运动管理的认识。 知识现状:定期体育锻炼有利于控制糖尿病,同时减少对胰岛素的需求。它还能降低危险的后期心血管并发症的风险。Meta 分析表明,体育锻炼对降低 HbA1c、BMI、甘油三酯和总胆固醇有显著效果。建议体力活动量大的 1 型糖尿病患者使用连续血糖监测(CGM)系统。运动开始时和运动过程中的最佳血糖值为:有氧运动 126-180 毫克/分升(7-10 毫摩尔/升),无氧运动 90-180 毫克/分升(5-10 毫摩尔/升)。胰岛素剂量的减少取决于运动类型、运动时长、治疗方法和运动前的血糖水平。 结论体育锻炼可改善对 1 型糖尿病的控制,从而降低该疾病并发症(包括心血管疾病)的风险。1 型糖尿病并非业余和专业体育运动的禁忌症。但是,需要考虑许多变量。每位 1 型糖尿病患者在开始运动前都必须接受适当的培训。
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引用次数: 0
Impact of Fasting and Dietary Interventions on the Development and Treatment of Non-Hodgkin’s Lymphomas and Other Cancers - a review 禁食和饮食干预对非霍奇金淋巴瘤和其他癌症的发展和治疗的影响--综述
Pub Date : 2024-07-18 DOI: 10.12775/qs.2024.17.52875
Krzysztof Bilecki, Paulina Cuper, Ilona Jastrzębska, Michał Andrzej Kozicz, Hubert Gugulski, Michał Bado, Patrycja Nowoświat, M. Goncerz
Introduction: The present study investigated the role of fasting and diet in the development and treatment of cancers, with a focus on non-Hodgkin’s lymphomas. Dietary components and regimens have an impact on the risk of development of malignances as well as on the treatment of the disease. Cancerous subtypes react differently to various dietary compounds and regimes. Although not widely used- fasting can be valuable help in cancer treatment. In this article we show how diet modifications and restrictions can affect existing therapies.Aim of the study: By analyzing current literature, the study aimed to understand how various dietary components and regimens influence cancer risk and treatment efficacy.Methods: Extensive research was conducted using PubMed and Google Scholar. References from selected articles were included in the analysis.Results: Consuming high amount of fruits and vegetables, unsaturated fats and supplementing vitamin D can reduce the risk of malignancies, with red meat, dairy products and saturated fats intake increasing it. Fasting affects lipid, glucose, protein and neuroendocrine metabolism in the way that helps the treatment of cancers. It slows down tumor growth, reduces some symptoms and improves the effects of chemotherapy. Exploring this topic further could propagate suitable diets for cancer subtypes as well as popularize fasting, which is not yet a widely known adition to standard anti-cancer treatments.
简介本研究调查了禁食和饮食在癌症发病和治疗中的作用,重点是非霍奇金淋巴瘤。饮食成分和方案对恶性肿瘤的发病风险和治疗都有影响。癌症亚型对各种膳食化合物和疗法的反应各不相同。禁食虽然没有得到广泛应用,但对癌症治疗有重要帮助。在本文中,我们将展示饮食调整和限制对现有疗法的影响:通过分析现有文献,本研究旨在了解各种饮食成分和方案如何影响癌症风险和治疗效果:方法:使用 PubMed 和 Google Scholar 进行了广泛的研究。方法:利用 PubMed 和 Google Scholar 进行了广泛研究,并将所选文章的参考文献纳入分析:结果:摄入大量水果和蔬菜、不饱和脂肪以及补充维生素 D 可以降低患恶性肿瘤的风险,而摄入红肉、乳制品和饱和脂肪则会增加患恶性肿瘤的风险。禁食会影响脂质、葡萄糖、蛋白质和神经内分泌的新陈代谢,有助于癌症的治疗。它能减缓肿瘤生长,减轻某些症状,改善化疗效果。对这一主题的进一步探索可以推广适合癌症亚型的饮食,并普及禁食,因为禁食尚未成为标准抗癌疗法的一个广为人知的补充。
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引用次数: 0
The treatment of hyperphagia and obesity in Prader-Willi Syndrome 治疗普拉德-威利综合征患者的多食症和肥胖症
Pub Date : 2024-07-18 DOI: 10.12775/qs.2024.17.52948
Ilona Jastrzębska, Paulina Cuper, Michał Andrzej Kozicz, Krzysztof Bilecki, Hubert Gugulski, Michał Bado, Patrycja Nowoświat
Introduction: Prader-Willi Syndrome (PWS) is a genetic neurodevelopmental disorder, in which the central clinical characteristics are hyperphagia and obesity. Obesity leads to higher mortality rates in PWS patients and thus, effective and safe treatment of hyperphagia and obesity in PWS individuals is an important aspect of PWS therapy. Aim of the study: The aim of the study was to research both the new and the more standard treatment options of hyperphagia and obesity in PWS patients. Methods and Materials: An extensive literature search was conducted using PubMed database. Only articles from the past 5 years were taken into consideration. The keywords used during the search were: prader willi syndrome, obesity, treatment. Results: Our research showed that in the treatment of hyperphagia and obesity in PWS patients, health professionals may consider the use of pharmacological treatment options, surgery and neuromodulatory options. Moreover, physical activity and environmental control are beneficial in limiting caloric intake and improving body mass index. Furthermore, early diagnosis and thus starting treatment in early childhood are beneficial in preventing the progression of obesity. However, more research is needed to determine which treatment options are best suited for specific patients. 
简介普拉德-威利综合征(PWS)是一种遗传性神经发育障碍疾病,其主要临床特征是多食和肥胖。肥胖会导致 PWS 患者的死亡率升高,因此,有效、安全地治疗 PWS 患者的多食症和肥胖症是 PWS 治疗的一个重要方面。研究目的本研究的目的是研究治疗 PWS 患者吞咽过度和肥胖症的新的和更标准的治疗方案。方法和材料:使用 PubMed 数据库进行了广泛的文献检索。只考虑了过去 5 年中的文章。搜索时使用的关键词为:Prader Willi 综合征、肥胖症、治疗。结果我们的研究表明,在治疗 PWS 患者的多食和肥胖症时,医疗专业人员可考虑使用药物治疗方案、手术和神经调节方案。此外,体育锻炼和环境控制有利于限制热量摄入和改善体重指数。此外,早期诊断并在儿童早期开始治疗有利于预防肥胖症的发展。然而,要确定哪些治疗方案最适合特定患者,还需要更多的研究。
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引用次数: 0
Effectiveness and Safety of Antifibrotic Treatment in Pulmonary Fibrosis Associated with Rheumatoid Arthritis 类风湿关节炎相关肺纤维化抗纤维化治疗的有效性和安全性
Pub Date : 2024-07-18 DOI: 10.12775/qs.2024.17.52930
Martyna Magdalena Martka, Marta Skorupska, Andrzej Aleksiej, Natalia Aleksandra Popławska, Justyna Śliz, M. Czeczotka, Krzysztof Woźniak
Introduction and Objective.Rheumatoid arthritis (RA) stands as a chronic, systemic autoimmune inflammatory ailment. Lung involvement is one of the most common extra-articular manifestations of RA. Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD) is a severe, progressive disease leading to pulmonary fibrosis, characterized by deterioration of lung function, exacerbation of symptoms and typical radiological features, and early mortality.Review methods and materialsThis review utilized PubMed, Mendeley by using search terms such as pulmonary fibrosis in rheumatoid arthritis nintedanib treatment, and pulmonary fibrosis in rheumatoid arthritis pirfenidone treatment. All searches were verified by humans, duplicated results and unreliable have been rejected. In addition, case reports and previously established literature reviews were excluded from the review. We used all available original studies evaluating and comparing the efficacy and safety of anti-fibrotic drugs to create this review.Brief description of the state of knowledge In this review, we discuss therapeutic strategies for antifibrotic treatment involving nintedanib and pirfenidone. Furthermore, we compare the efficacy of both drugs, their influence on the extension of life, their safety profiles, and associated side effects based on research findings, and discuss the molecular mechanisms of their action. SummaryClinical trials concerning RA-ILD showed that nintedanib and pirfenidone slow the rate of FVC decline in patients with RA-ILD. The safety profile observed in both drugs was similar simultaneously occurring mainly gastrointestinal symptoms. Both drugs have been approved for the RA-ILD treatment program, nevertheless in the current body of knowledge, it is not feasible to definitively determine which drug therapy should be initiated first, as their characteristics are notably similar.
导言和目的:类风湿性关节炎(RA)是一种慢性、全身性自身免疫性炎症。肺部受累是类风湿关节炎最常见的关节外表现之一。类风湿性关节炎相关间质性肺病(RA-ILD)是一种严重的进行性疾病,会导致肺纤维化,其特点是肺功能恶化、症状加重和典型的放射学特征,以及早期死亡。综述方法和材料本综述利用PubMed、Mendeley,使用了类风湿性关节炎宁替达尼治疗中的肺纤维化、类风湿性关节炎吡非尼酮治疗中的肺纤维化等检索词。所有检索结果均经过人工验证,重复和不可靠的结果均被剔除。此外,病例报告和先前已发表的文献综述也不在综述范围内。我们使用了所有可用的评估和比较抗纤维化药物疗效和安全性的原始研究来撰写这篇综述。 在这篇综述中,我们讨论了涉及宁替达尼和吡非尼酮的抗纤维化治疗策略。此外,我们还根据研究结果比较了这两种药物的疗效、对延长寿命的影响、安全性和相关副作用,并讨论了它们的分子作用机制。摘要有关 RA-ILD 的临床试验显示,宁替达尼和吡非尼酮可减缓 RA-ILD 患者 FVC 的下降速度。两种药物的安全性相似,同时主要出现胃肠道症状。这两种药物都已被批准用于 RA-ILD 治疗方案,但就目前的知识体系而言,还无法明确确定应首先开始哪种药物治疗,因为这两种药物的特点非常相似。
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引用次数: 0
From Genes to Gym: The Impact of Physical Exercise on Arrhythmogenic Right Ventricular Cardiomyopathy 从基因到健身房:体育锻炼对心律失常性右室心肌病的影响
Pub Date : 2024-07-18 DOI: 10.12775/qs.2024.17.52984
Adam Kucharski, Konrad Pilarski, Rafał Makuch, Alicja Chrościcka, Kamil Gała, Andrzej Czajka, Paweł Lenard, Sara Michalska, Martyna Dewicka, Alicja Maria Wawrzyniak
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary heart muscle disorder characterized by the progressive replacement of right ventricular myocardium with fibrofatty tissue. This condition predisposes individuals to arrhythmias and an elevated risk of sudden cardiac death (SCD). The etiology of ARVC is predominantly genetic, with mutations in genes encoding desmosomal proteins playing a crucial role. Physical exercise has a significant impact on the progression of ARVC, often exacerbating the disease's severity and increasing the likelihood of life-threatening arrhythmic events. Diagnosing ARVC remains challenging due to its variable clinical presentation and overlapping features with other cardiomyopathies. Advanced imaging techniques, electrocardiography, and genetic testing are essential tools in the diagnostic process. Treatment strategies for ARVC include lifestyle modifications, pharmacotherapy, implantable cardioverter-defibrillators (ICDs), and in some cases, catheter ablation or heart transplantation. Preventing disease progression and SCD involves a multidisciplinary approach, emphasizing early diagnosis, risk stratification, and tailored therapeutic interventions. This review comprehensively examines the etiology of ARVC, the detrimental effects of physical exercise on the disease, the associated SCD risk, and the challenges in diagnosis, while also discussing current treatment modalities and preventive measures to mitigate disease progression. Materials and Methods Review and summary of research studies available in databases on Google Scholar and PubMed. Databases such as PubMed and Google Scholar were searched using the keywords: ‘Arrhythmogenic right ventricular cardiomyopathy, ‘ARVC in athletes’, ‘Sudden cardiac death’, ‘impact of physical exercise on ARVC’.
致心律失常性右心室心肌病(ARVC)是一种遗传性心肌疾病,其特征是右心室心肌逐渐被纤维脂肪组织取代。这种疾病易导致心律失常,并增加心脏性猝死(SCD)的风险。ARVC 的病因主要是遗传因素,其中编码脱膜蛋白的基因突变起着至关重要的作用。体育锻炼对 ARVC 的病情发展有重大影响,往往会加重疾病的严重程度,增加发生危及生命的心律失常事件的可能性。由于 ARVC 的临床表现多变,且与其他心肌病的特征重叠,因此诊断 ARVC 仍具有挑战性。先进的成像技术、心电图和基因检测是诊断过程中必不可少的工具。ARVC 的治疗策略包括改变生活方式、药物治疗、植入式心律转复除颤器 (ICD),在某些情况下还可进行导管消融或心脏移植。预防疾病进展和 SCD 需要采用多学科方法,强调早期诊断、风险分层和有针对性的治疗干预。本综述全面探讨了 ARVC 的病因、体育锻炼对疾病的不利影响、相关的 SCD 风险和诊断中的挑战,同时还讨论了当前的治疗模式和预防措施,以缓解疾病进展。材料与方法 对谷歌学术和 PubMed 数据库中的研究进行回顾和总结。使用关键字搜索 PubMed 和 Google Scholar 等数据库:致心律失常性右室心肌病"、"运动员中的 ARVC"、"心脏性猝死"、"体育锻炼对 ARVC 的影响"。
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引用次数: 0
Does diet influence the development and treatment of endometriosis? - A literature review 饮食会影响子宫内膜异位症的发生和治疗吗?- 文献综述
Pub Date : 2024-07-18 DOI: 10.12775/qs.2024.17.52932
Justyna Szpyra, Ł. Gawlik, Piotr Jagodowski, Jagna Golemo, Julia Dębińska, Magdalena Ostojska, Magdalena Celichowska, Magdalena Górska, Gabriela Dziuba, Aleksandra Bogoń
Introduction and objective: Endometriosis is a chronic disease that can cause symptoms that significantly worsen the quality of life of patients. Treatment methods often fail to produce satisfactory results. Therefore, there is growing interest in the potential role of diet in prevention and management of endometriosis. The aim of the review is to analyze available scientific literature on the impact of diet on the development and alleviation of endometriosis symptoms and the possibility of its use in clinical practice. Brief description of the state of knowledge: Both nutrient deficiencies and excesses can affect health, with gene-nutrient interactions playing a key role in disease prevention and progression. Nutrition can alter gene expression and disease susceptibility, making the study of diet's influence on gynecological diseases like endometriosis important. Research suggests dietary changes can improve symptoms and quality of life for patients with endometriosis. Conclusions: This study confirms that consuming or limiting some of the nutrients can reduce the risk of developing endometriosis and alleviate its symptoms. However, there are many contradictions in the research. The role of diet and nutrition in endometriosis still remains an unexplored area that requires further investigation.
导言和目的:子宫内膜异位症是一种慢性疾病,其症状会严重影响患者的生活质量。治疗方法往往无法取得令人满意的效果。因此,人们越来越关注饮食在预防和治疗子宫内膜异位症中的潜在作用。本综述旨在分析有关饮食对子宫内膜异位症症状发展和缓解的影响及其在临床实践中应用的可能性的现有科学文献。知识现状简介:营养素缺乏和过剩都会影响健康,基因与营养素的相互作用在疾病的预防和发展中起着关键作用。营养可改变基因表达和疾病易感性,因此研究饮食对子宫内膜异位症等妇科疾病的影响非常重要。研究表明,改变饮食可改善子宫内膜异位症患者的症状和生活质量。结论这项研究证实,摄入或限制某些营养素可降低患子宫内膜异位症的风险并减轻其症状。然而,研究中也存在许多矛盾之处。饮食和营养在子宫内膜异位症中的作用仍是一个尚未探索的领域,需要进一步研究。
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引用次数: 0
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Quality in Sport
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