Objectives: The study aims to delineate the occurrence of musculoskeletal symptoms among COVID-19 patients admitted to hospitals and explore the relationship between interleukin levels and C-reactive protein (CRP). Materials and Methods: A study involving the review of medical records was carried out on 109 patients aged 18 and above who were COVID-19 positive and hospitalized during treatment. Pregnant individuals with severe illnesses or insufficient data were excluded from the analysis. Demographic information and laboratory findings were extracted from a health database from earlier research conducted at the same hospital. The investigation focused on establishing the connection between musculoskeletal manifestations, CRP, and interleukin levels. P values less than 0.05 were accepted as statistically significant. Results: A total of 109 individuals were assessed in this study. Among the patients, 34.86% (n = 38) reported arthralgia, 1.83% (n = 2) had arthritis, 41.28% (n = 45) experienced fatigue, and 32.11% (n = 35) encountered post-COVID-19 syndrome. Notably, no significant correlation was observed between musculoskeletal manifestations, CRP, and interleukin levels (P>0.05). However, a positive correlation was identified between post-COVID-19 syndrome, fatigue, duration of O2 support, and duration of hospitalization (P<0.05). Additionally, 54% of the patients were elderly, aged 65 years or older. Furthermore, CRP levels exhibited a positive correlation with the duration of hospitalization, O2 support, history of intensive care, and duration of intensive care (P<0.05). Regarding interleukin levels, there was a positive correlation between interleukin-6 and CRP levels, duration of hospitalization, and O2 support duration (P<0.05). No significant correlation was found between interleukin-6 and interleukin-10 levels (P>0.05). Conclusions: No correlation was observed between musculoskeletal symptoms and levels of CRP and interleukin. It is recommended to monitor individuals who have been hospitalized, elderly, experiencing unusual fatigue, or relying on oxygen support for the development of post-COVID-19 syndrome.
{"title":"Musculoskeletal Symptoms in Individuals Afflicted by COVID-19","authors":"Ozlem Kuculmez, G. Genctoy, Serap Arikan","doi":"10.34172/cjmb.2024.3010","DOIUrl":"https://doi.org/10.34172/cjmb.2024.3010","url":null,"abstract":"Objectives: The study aims to delineate the occurrence of musculoskeletal symptoms among COVID-19 patients admitted to hospitals and explore the relationship between interleukin levels and C-reactive protein (CRP). Materials and Methods: A study involving the review of medical records was carried out on 109 patients aged 18 and above who were COVID-19 positive and hospitalized during treatment. Pregnant individuals with severe illnesses or insufficient data were excluded from the analysis. Demographic information and laboratory findings were extracted from a health database from earlier research conducted at the same hospital. The investigation focused on establishing the connection between musculoskeletal manifestations, CRP, and interleukin levels. P values less than 0.05 were accepted as statistically significant. Results: A total of 109 individuals were assessed in this study. Among the patients, 34.86% (n = 38) reported arthralgia, 1.83% (n = 2) had arthritis, 41.28% (n = 45) experienced fatigue, and 32.11% (n = 35) encountered post-COVID-19 syndrome. Notably, no significant correlation was observed between musculoskeletal manifestations, CRP, and interleukin levels (P>0.05). However, a positive correlation was identified between post-COVID-19 syndrome, fatigue, duration of O2 support, and duration of hospitalization (P<0.05). Additionally, 54% of the patients were elderly, aged 65 years or older. Furthermore, CRP levels exhibited a positive correlation with the duration of hospitalization, O2 support, history of intensive care, and duration of intensive care (P<0.05). Regarding interleukin levels, there was a positive correlation between interleukin-6 and CRP levels, duration of hospitalization, and O2 support duration (P<0.05). No significant correlation was found between interleukin-6 and interleukin-10 levels (P>0.05). Conclusions: No correlation was observed between musculoskeletal symptoms and levels of CRP and interleukin. It is recommended to monitor individuals who have been hospitalized, elderly, experiencing unusual fatigue, or relying on oxygen support for the development of post-COVID-19 syndrome.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyit Ali Bingöl, S. Yiğit, Ergin Taşkın, F. Kacı, M. Yayla, N. Baygutalp, Erdem Toktay, Nilnur Eyerci, H. Çılgın
Objectives: Ovarian torsion is an important gynaecological emergency because it causes ischemia in ovary. Our aim is to research the effects of Hypericum perforatum on p53, TNF-α, CAT, SOD, GSH, PTEN and is haPI3K/Akt/mTOR pathway in ovarian of rats with ischemia reperfusion (I/R) injury. Materials and Methods: The study included 56 adult female rats which were allocated to 7 groups; control, ischemia, ischemia 300HP, ischemia 600HP, I/R, I/R 300HP and I/R 600HP. H. perforatum was applied to ischemia 300HP, ischemia 600HP, I/R 300HP and I/R 600HP groups at the dose of 300 mg/kg or 600 mg/kg by oral gavage. Collected ovarian tissues were examined by light microscopy, biochemical and real-time PCR techniques. Results: In histological examination, the least degeneration was seen in 600HP group among other groups, apart from control group. TUNEL results showed that apoptosis level of other groups was lower than that of ischemia and I/R groups. CAT and GSH levels of I/R 600HP group increased. The highest level of PTEN and mTOR was found in the ischemia group. The Akt level was lower in I/R and I/R 300HP groups but its level was close to that of control and I/R 600HP groups. TNF-α and p53 mRNA expressions in I/R group were increased. Conclusions: The result of the study showed that H. perforatum (600 mg/kg) had an effect on tissue degeneration, CAT and GSH levels, and also TNF-α and p53 mRNA expressions levels. We suggest that H. perforatum can be considered as an agent to protect against tissues damage during ischemia reperfusion.
{"title":"Determination of the Protective Impact of Hypericum perforatum Extract Against Ovarian Ischemia and Reperfusion in Rats","authors":"Seyit Ali Bingöl, S. Yiğit, Ergin Taşkın, F. Kacı, M. Yayla, N. Baygutalp, Erdem Toktay, Nilnur Eyerci, H. Çılgın","doi":"10.34172/cjmb.2024.3720","DOIUrl":"https://doi.org/10.34172/cjmb.2024.3720","url":null,"abstract":"Objectives: Ovarian torsion is an important gynaecological emergency because it causes ischemia in ovary. Our aim is to research the effects of Hypericum perforatum on p53, TNF-α, CAT, SOD, GSH, PTEN and is haPI3K/Akt/mTOR pathway in ovarian of rats with ischemia reperfusion (I/R) injury. Materials and Methods: The study included 56 adult female rats which were allocated to 7 groups; control, ischemia, ischemia 300HP, ischemia 600HP, I/R, I/R 300HP and I/R 600HP. H. perforatum was applied to ischemia 300HP, ischemia 600HP, I/R 300HP and I/R 600HP groups at the dose of 300 mg/kg or 600 mg/kg by oral gavage. Collected ovarian tissues were examined by light microscopy, biochemical and real-time PCR techniques. Results: In histological examination, the least degeneration was seen in 600HP group among other groups, apart from control group. TUNEL results showed that apoptosis level of other groups was lower than that of ischemia and I/R groups. CAT and GSH levels of I/R 600HP group increased. The highest level of PTEN and mTOR was found in the ischemia group. The Akt level was lower in I/R and I/R 300HP groups but its level was close to that of control and I/R 600HP groups. TNF-α and p53 mRNA expressions in I/R group were increased. Conclusions: The result of the study showed that H. perforatum (600 mg/kg) had an effect on tissue degeneration, CAT and GSH levels, and also TNF-α and p53 mRNA expressions levels. We suggest that H. perforatum can be considered as an agent to protect against tissues damage during ischemia reperfusion.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
complicated hormonal condition of the women in reproductive age with a prevalence of 5–15% (1). Its characteristic features include polycystic ovary morphology under sonography, ovulatory dysfunction, and hyperandrogenism (2). Irrespective of reproductive disorders, it was reported that PCOS is implicated with the disorders of metabolism such as type 2 diabetes (T2DM), cardiovascular diseases, and impaired glucose tolerance (3). In PCOS, the tendency for fat accumulation in intraabdominal stores of fat is frequently observed, and it is linked to an increased risk of cardiovascular disorders and T2DM (4). A woman with PCOS usually visit the physician for reasons such as obesity, hair loss, hypertension, impaired glucose tolerance, and hyperlipidemia. On the other hand, the exact diagnosis of PCOS is made by a gynecologist according to the Rotterdam consensus criteria (5) at the end. Its early detection using simple markers by other medical disciplines rather than the gynecologists will reduce the burden attributable to metabolic risks. It was reported that the conventional ratios of lipid such as low-density lipoprotein cholesterol (LDL-C)/ highdensity lipoprotein cholesterol (HDL-C), total cholesterol (TC) / HDL-C, triglycerides (TG)/HDL-C, and fasting TG are elevated in PCOS patients (6). In insulin-resistant (IR) states, delayed TG-rich lipoprotein clearance from blood plasma results in hypertriglyceridemia (7). The triglyceride glucose (TyG) index is obtained by the formula: napierian logarithmic (ln) [fasting TG (mg/dL) × fasting blood glucose (FBG) (mg/dL)/2] and it was firstly reported as an index to identify IR (8). TyG index predicts glycolipid-metabolism-related diseases efficiently (8). Triglyceride glucose-body mass index (TyG-BMI) has been recently reported to be a helpful marker in early detection of T2DM risk, which is a common phenomenon in PCOS (9, 10). TyG-BMI, calculated as [TyG × BMI], was also shown as a non-invasive, simple, and cost-effective tool for separating the patients with non-alcoholic fatty liver Diagnosing Polycystic Ovary Syndrome Using TriglycerideRelated Indices: Is It Possible Without Rotterdam Criteria?
{"title":"Diagnosing Polycystic Ovary Syndrome Using Triglyceride-Related Indices: Is It Possible Without Rotterdam Criteria?","authors":"Betül Keyif, Ali Yavuzcan, Mertihan Kurdoğlu","doi":"10.34172/cjmb.2023.4007","DOIUrl":"https://doi.org/10.34172/cjmb.2023.4007","url":null,"abstract":"complicated hormonal condition of the women in reproductive age with a prevalence of 5–15% (1). Its characteristic features include polycystic ovary morphology under sonography, ovulatory dysfunction, and hyperandrogenism (2). Irrespective of reproductive disorders, it was reported that PCOS is implicated with the disorders of metabolism such as type 2 diabetes (T2DM), cardiovascular diseases, and impaired glucose tolerance (3). In PCOS, the tendency for fat accumulation in intraabdominal stores of fat is frequently observed, and it is linked to an increased risk of cardiovascular disorders and T2DM (4). A woman with PCOS usually visit the physician for reasons such as obesity, hair loss, hypertension, impaired glucose tolerance, and hyperlipidemia. On the other hand, the exact diagnosis of PCOS is made by a gynecologist according to the Rotterdam consensus criteria (5) at the end. Its early detection using simple markers by other medical disciplines rather than the gynecologists will reduce the burden attributable to metabolic risks. It was reported that the conventional ratios of lipid such as low-density lipoprotein cholesterol (LDL-C)/ highdensity lipoprotein cholesterol (HDL-C), total cholesterol (TC) / HDL-C, triglycerides (TG)/HDL-C, and fasting TG are elevated in PCOS patients (6). In insulin-resistant (IR) states, delayed TG-rich lipoprotein clearance from blood plasma results in hypertriglyceridemia (7). The triglyceride glucose (TyG) index is obtained by the formula: napierian logarithmic (ln) [fasting TG (mg/dL) × fasting blood glucose (FBG) (mg/dL)/2] and it was firstly reported as an index to identify IR (8). TyG index predicts glycolipid-metabolism-related diseases efficiently (8). Triglyceride glucose-body mass index (TyG-BMI) has been recently reported to be a helpful marker in early detection of T2DM risk, which is a common phenomenon in PCOS (9, 10). TyG-BMI, calculated as [TyG × BMI], was also shown as a non-invasive, simple, and cost-effective tool for separating the patients with non-alcoholic fatty liver Diagnosing Polycystic Ovary Syndrome Using TriglycerideRelated Indices: Is It Possible Without Rotterdam Criteria?","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135204330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arman Khatami, Ghazal Rahmanifar, Arash Khaki, Afshin Teymoori, Ali Rezaii
Objectives: Testicular torsion is a critical medical condition necessitating prompt diagnosis and intervention. This study aimed to explore the potential safeguarding effect of carvacrol against histological damage and oxidative stress resulting from torsion/detorsion (T/D) in rat testes. Materials and Methods: A total of 32 adult male rats were randomly divided into four groups. The sham group did not undergo any intervention. The second group received an intraperitoneal injection of 75 mg/kg carvacrol half an hour before detorsion application. The third group was administered 80 mg/kg carvacrol intraperitoneally without detorsion. The fourth group (control) experienced (T/D) through the administration of saline. Following a 5-hour reperfusion period, the left testis was excised for histological slide preparation. Blood serum was used to measure antioxidant enzyme levels. Data analysis was performed using the SPSS version 19 software and analysis of variance tests. Results: Significant histological alterations were observed between the sham and other three groups. The levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and testosterone significantly decreased in all treatment groups compared to the control group (P<0.05). Conversely, malondialdehyde (MDA) levels increased in the torsion control group in contrast to the sham group (P<0.05). Carvacrol administration mitigated MDA levels in the treatment groups. Also, there were significant differences in tissue parameters between the sham and the other groups (P<0.05). Conclusions: According to the results of this study, carvacrol possesses the potential to mitigate testicular tissue damage, enhance testicular function, and ameliorate oxidative stress consequential to testicular rotation.
{"title":"Preservation of Testicular Tissue and Alleviation of Oxidative Stress by Carvacrol Following Torsion/ Detorsion in Adult Male Rats","authors":"Arman Khatami, Ghazal Rahmanifar, Arash Khaki, Afshin Teymoori, Ali Rezaii","doi":"10.34172/cjmb.2023.4006","DOIUrl":"https://doi.org/10.34172/cjmb.2023.4006","url":null,"abstract":"Objectives: Testicular torsion is a critical medical condition necessitating prompt diagnosis and intervention. This study aimed to explore the potential safeguarding effect of carvacrol against histological damage and oxidative stress resulting from torsion/detorsion (T/D) in rat testes. Materials and Methods: A total of 32 adult male rats were randomly divided into four groups. The sham group did not undergo any intervention. The second group received an intraperitoneal injection of 75 mg/kg carvacrol half an hour before detorsion application. The third group was administered 80 mg/kg carvacrol intraperitoneally without detorsion. The fourth group (control) experienced (T/D) through the administration of saline. Following a 5-hour reperfusion period, the left testis was excised for histological slide preparation. Blood serum was used to measure antioxidant enzyme levels. Data analysis was performed using the SPSS version 19 software and analysis of variance tests. Results: Significant histological alterations were observed between the sham and other three groups. The levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and testosterone significantly decreased in all treatment groups compared to the control group (P<0.05). Conversely, malondialdehyde (MDA) levels increased in the torsion control group in contrast to the sham group (P<0.05). Carvacrol administration mitigated MDA levels in the treatment groups. Also, there were significant differences in tissue parameters between the sham and the other groups (P<0.05). Conclusions: According to the results of this study, carvacrol possesses the potential to mitigate testicular tissue damage, enhance testicular function, and ameliorate oxidative stress consequential to testicular rotation.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: This study aimed to evaluate the effect of carvacrol and treadmill exercise on oxidative stress and testis structure in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In this experimental study, the diabetes was induced using a single intraperitoneal (IP) injection of STZ (50 mg/kg). The rats were assigned to five groups, namely a control group, a diabetic control group, a diabetic group receiving daily carvacrol at a dose of 75 mg/kg, diabetic groups performing treadmill exercise, and a diabetic group performing daily treadmill exercise and receiving carvacrol. After covering the treatment period, all rats were anesthetized and their blood sample were taken. Then the serum levels of oxidative stress markers were measured, the testicles and epididymis were removed, and the sperm parameters were assessed. Results: The treatment of diabetic rats with carvacrol and treadmill exercise effectively improved testis tissue damage, sperm parameters, glucose, and insulin plasma levels (P=0.001). In diabetic rats, the level of malondialdehyde (MDA) increased while the activity of superoxide dismutase (SOD) and catalase (CAT) enzymes decreased in the testes tissue (P=0.001). However, when carvacrol administration (75 mg/kg) was combined with treadmill exercise, these parameters were significantly rectified (P<0.05). Conclusion: In sum, administering carvacrol and performing treadmill exercise were effective in improving the sperm parameters and testicular oxidative damage caused by diabetes.
{"title":"The Effect of Carvacrol Plus Treadmill Exercise on Testis Structure and Oxidative Stress in Streptozotocin-Induced Diabetic Rats","authors":"Ramesh Bradaran Bagheri, Jamal Shadman, A. Khaki","doi":"10.34172/cjmb.2023.24","DOIUrl":"https://doi.org/10.34172/cjmb.2023.24","url":null,"abstract":"Objectives: This study aimed to evaluate the effect of carvacrol and treadmill exercise on oxidative stress and testis structure in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In this experimental study, the diabetes was induced using a single intraperitoneal (IP) injection of STZ (50 mg/kg). The rats were assigned to five groups, namely a control group, a diabetic control group, a diabetic group receiving daily carvacrol at a dose of 75 mg/kg, diabetic groups performing treadmill exercise, and a diabetic group performing daily treadmill exercise and receiving carvacrol. After covering the treatment period, all rats were anesthetized and their blood sample were taken. Then the serum levels of oxidative stress markers were measured, the testicles and epididymis were removed, and the sperm parameters were assessed. Results: The treatment of diabetic rats with carvacrol and treadmill exercise effectively improved testis tissue damage, sperm parameters, glucose, and insulin plasma levels (P=0.001). In diabetic rats, the level of malondialdehyde (MDA) increased while the activity of superoxide dismutase (SOD) and catalase (CAT) enzymes decreased in the testes tissue (P=0.001). However, when carvacrol administration (75 mg/kg) was combined with treadmill exercise, these parameters were significantly rectified (P<0.05). Conclusion: In sum, administering carvacrol and performing treadmill exercise were effective in improving the sperm parameters and testicular oxidative damage caused by diabetes.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48765592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Significance of the First Impact Factor: Propelling Our Journal Forward","authors":"A. Khaki","doi":"10.34172/cjmb.2023.17","DOIUrl":"https://doi.org/10.34172/cjmb.2023.17","url":null,"abstract":"","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44920643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Haghighi, Bahram Naderi Nabi, H. Khoshrang, S. Rimaz, Soudabeh Haddadi, A. Parvizi, M. Mobayen, Gelareh Biazar, Tayebeh Zarei
Objectives: Poor pain control in burn patients as a great public health problem disrupts the healing and rehabilitation process and results in several adverse outcomes. The aim of this study was to investigate the efficacy and safety of intravenous lidocaine in reducing the pain of burn injuries. Materials and Methods: From August 2014 to March 2015, 66 eligible burn patients participated in the study and were randomly divided into two groups of lidocaine (L) and placebo (P). In group L, lidocaine 2% was injected at a bolus dose of 1.5 mg/kg followed by infusion at the dosage of 1.5 mg/kg/h, and in group P, saline was administrated. Pain severity was measured during 24 hours at baseline and 1, 2, 4, 8, 12, 16, 20, 24 hours after intervention based on Numerical Rating Scale (NRS-11). Morphine consumption, Ramsay score, and side effects were also documented. Results: Finally the data from 60 patients were analyzed. Comparing baseline with 24 hours after intervention, NRS-11 scores decreased from 7.12±1.42 to 3.33±0.76 (P<0.001) in group P and from 6.45±1.02 to 2.50±0.72 (P<0.001) in group L. Moreover, the mean of NRS scores during 24 hours in the lidocaine group was significantly lower compared to the placebo group, 3.93±0.72 vs 4.73 ±1.14, (P=0.03). The mean amounts of morphine consumption in group L were significantly lower compared to group P, 14.41 ± 4.86 vs 21.07±6.86, (P=0.001). The mean of Ramsay score in group L was significantly lower compared to group P, 1.38±0.59 vs 1.45±0.6, (P=0.014). Conclusions: This study revealed that intravenous lidocaine was an effective and safe drug for pain reduction in burn patients.
{"title":"The Effectiveness of Intravenous lidocaine in Burn Pain Relief: A Randomized Double-Blind Controlled Trial","authors":"M. Haghighi, Bahram Naderi Nabi, H. Khoshrang, S. Rimaz, Soudabeh Haddadi, A. Parvizi, M. Mobayen, Gelareh Biazar, Tayebeh Zarei","doi":"10.34172/cjmb.2023.18","DOIUrl":"https://doi.org/10.34172/cjmb.2023.18","url":null,"abstract":"Objectives: Poor pain control in burn patients as a great public health problem disrupts the healing and rehabilitation process and results in several adverse outcomes. The aim of this study was to investigate the efficacy and safety of intravenous lidocaine in reducing the pain of burn injuries. Materials and Methods: From August 2014 to March 2015, 66 eligible burn patients participated in the study and were randomly divided into two groups of lidocaine (L) and placebo (P). In group L, lidocaine 2% was injected at a bolus dose of 1.5 mg/kg followed by infusion at the dosage of 1.5 mg/kg/h, and in group P, saline was administrated. Pain severity was measured during 24 hours at baseline and 1, 2, 4, 8, 12, 16, 20, 24 hours after intervention based on Numerical Rating Scale (NRS-11). Morphine consumption, Ramsay score, and side effects were also documented. Results: Finally the data from 60 patients were analyzed. Comparing baseline with 24 hours after intervention, NRS-11 scores decreased from 7.12±1.42 to 3.33±0.76 (P<0.001) in group P and from 6.45±1.02 to 2.50±0.72 (P<0.001) in group L. Moreover, the mean of NRS scores during 24 hours in the lidocaine group was significantly lower compared to the placebo group, 3.93±0.72 vs 4.73 ±1.14, (P=0.03). The mean amounts of morphine consumption in group L were significantly lower compared to group P, 14.41 ± 4.86 vs 21.07±6.86, (P=0.001). The mean of Ramsay score in group L was significantly lower compared to group P, 1.38±0.59 vs 1.45±0.6, (P=0.014). Conclusions: This study revealed that intravenous lidocaine was an effective and safe drug for pain reduction in burn patients.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42133169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Aliakbari, T. Jamshidi, Rezvaneh Manzour, Fatemeh Haj Hashemi
Objectives: Suicide is a serious public health problem, especially among students as active members of the community. The present study aimed to determine the correlation among personality characteristics, family functioning, and suicidal ideation in students of Shahid Beheshti University of Medical Sciences in Tehran, Iran in 2018. Materials and Methods: The population of this descriptive correlational study included all 675 students of Shahid Beheshti University of Medical Sciences, from whom 244 students were selected using stratified random sampling. The required data was collected using four questionnaires, including demographic characteristics, personality traits, family functioning, and Beck Scale for Suicidal Ideation (BSSI). To analyze data, we used multiple linear regression and the Statistical Package for the Social Sciences (SPSS, version 22). Results: Examination of personality traits suggested that the correlation between psychosis and suicidal thoughts was positive and significant (P<0.05). The correlation coefficients between the components of extraversion-introversion, agreeability, and responsibility and suicidal ideation were negative and significant (P<0.05). There was also a positive and significant relationship between all components of family functioning and suicidal ideation (P<0.05). Conclusions: Effective steps can be taken to prevent suicide among students through providing optimal psychological healthcare and periodic screening of students in terms of suicidal thoughts and mental disorders.
{"title":"Investigating the Correlation Among Personality Traits, Familial Functioning, and Suicidal Thoughts Among University Students: A Descriptive Correlational Study","authors":"Fatemeh Aliakbari, T. Jamshidi, Rezvaneh Manzour, Fatemeh Haj Hashemi","doi":"10.34172/cjmb.2023.23","DOIUrl":"https://doi.org/10.34172/cjmb.2023.23","url":null,"abstract":"Objectives: Suicide is a serious public health problem, especially among students as active members of the community. The present study aimed to determine the correlation among personality characteristics, family functioning, and suicidal ideation in students of Shahid Beheshti University of Medical Sciences in Tehran, Iran in 2018. Materials and Methods: The population of this descriptive correlational study included all 675 students of Shahid Beheshti University of Medical Sciences, from whom 244 students were selected using stratified random sampling. The required data was collected using four questionnaires, including demographic characteristics, personality traits, family functioning, and Beck Scale for Suicidal Ideation (BSSI). To analyze data, we used multiple linear regression and the Statistical Package for the Social Sciences (SPSS, version 22). Results: Examination of personality traits suggested that the correlation between psychosis and suicidal thoughts was positive and significant (P<0.05). The correlation coefficients between the components of extraversion-introversion, agreeability, and responsibility and suicidal ideation were negative and significant (P<0.05). There was also a positive and significant relationship between all components of family functioning and suicidal ideation (P<0.05). Conclusions: Effective steps can be taken to prevent suicide among students through providing optimal psychological healthcare and periodic screening of students in terms of suicidal thoughts and mental disorders.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44854743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Katebi, Z. Aghazadeh, V. Sadra, M. Aghazadeh, M. Lak, Ehsan Habibivand
Objectives: Due to the important influence of glycemic control on oral health, this study aimed to compare the gingival index and decayed, missing, filled teeth (DMFT) in participants with type 2 diabetes mellitus receiving insulin and metformin. Materials and Methods: In this cross-sectional study, 130 participants with type 2 diabetes mellitus treated with insulin and metformin were studied in two groups based on the type of treatment. The information for DMFT and gingival indices were obtained using the oral examination. In the insulin group, participants received insulin Lantus 0.2 unit/kg once daily, and in the metformin group, participants received metformin tablets 500 mg every 12 hours. Glycosylated hemoglobin A1c (HbA1c) was measured by lab test in all participants. Finally, HbA1c, the information of DMFT, and gingival indices were compared between the two groups. Results: The results showed that there were no statistically significant differences in decayed, missed, and restored teeth, as well as the overall DMFT index between the two groups. The gingival index was significantly higher in the insulin group (P=0.046). Conclusions: Gingival health of insulin users is poorer than metformin users, but it seems that type of diabetes treatment does not affect the DMFT index
{"title":"Oral Health Indices in Patients With Type 2 Diabetes Receiving Insulin Treatment Compared With Metformin: A Cross-sectional Study","authors":"K. Katebi, Z. Aghazadeh, V. Sadra, M. Aghazadeh, M. Lak, Ehsan Habibivand","doi":"10.34172/cjmb.2023.20","DOIUrl":"https://doi.org/10.34172/cjmb.2023.20","url":null,"abstract":"Objectives: Due to the important influence of glycemic control on oral health, this study aimed to compare the gingival index and decayed, missing, filled teeth (DMFT) in participants with type 2 diabetes mellitus receiving insulin and metformin. Materials and Methods: In this cross-sectional study, 130 participants with type 2 diabetes mellitus treated with insulin and metformin were studied in two groups based on the type of treatment. The information for DMFT and gingival indices were obtained using the oral examination. In the insulin group, participants received insulin Lantus 0.2 unit/kg once daily, and in the metformin group, participants received metformin tablets 500 mg every 12 hours. Glycosylated hemoglobin A1c (HbA1c) was measured by lab test in all participants. Finally, HbA1c, the information of DMFT, and gingival indices were compared between the two groups. Results: The results showed that there were no statistically significant differences in decayed, missed, and restored teeth, as well as the overall DMFT index between the two groups. The gingival index was significantly higher in the insulin group (P=0.046). Conclusions: Gingival health of insulin users is poorer than metformin users, but it seems that type of diabetes treatment does not affect the DMFT index","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43831717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Insufficient physical activity is considered one of the leading causes of premature death worldwide. This study, therefore, aimed to investigate the effects of six weeks of moderate-intensity aerobic exercise on serum levels of Klotho, interleukin 10 (IL-10), IL-1, and oxidative stress in young women with a sedentary lifestyle. Materials and Methods: The present study was a semi-experimental study with a control group. Out of all volunteers, 20 young women eligible to participate in the study were selected and divided into the two groups (n=10) of experimental (i.e., six weeks of moderate-intensity aerobic exercise) and control (i.e., no exercise). Members of the experimental group performed an aerobic exercise program including running on a treadmill with an intensity of 55%-70% of their maximum heart rates (220-age). The running plan started with 50% of their maximum heart rates and reached 70% at the end of the six-week exercise program (three sessions per week). Paired t-test and independent t-test were conducted to examine intra-group and inter-group differences. All statistical procedures were performed using the SPSS version26 statistical package (P≤0.05). Results: At the beginning of the study, no significant difference was observed between the groups in terms of the markers. Six-week aerobic training increased Klotho (mean: 540, lower: 141.5, upper: 938.4) and IL-10 (mean: 0.43, lower: -1.56 upper: -0.47) in experimental group in comparison to control group (P=0.001). Six-week aerobic training decreased IL-1 (mean: 0.78, lower: -1.16 upper: -0.39) and H2O2 (mean: 0.41, lower: -0.96, upper: 0.12) in experimental group in comparison to control group (P=0.001). Conclusions: In sum, six-week moderate-intensity aerobic exercise program increased Klotho and IL-10 levels and decreased IL-1 and oxidative stress levels in young women with a sedentary lifestyle. According to these results, the decrease in oxidative stress and IL-1 levels due to exercise caused an increase in Klotho, and an increase in Klotho level, in turn, increased IL-10.
{"title":"The Effects of a Six-Week Aerobic Exercise on Serum Levels of Klotho, IL-10, IL-1, and Oxidative Stress in Sedentary Young Women","authors":"Mahrnaz Haji Abedin Rangraz, S. Hojjat","doi":"10.34172/cjmb.2023.11","DOIUrl":"https://doi.org/10.34172/cjmb.2023.11","url":null,"abstract":"Objectives: Insufficient physical activity is considered one of the leading causes of premature death worldwide. This study, therefore, aimed to investigate the effects of six weeks of moderate-intensity aerobic exercise on serum levels of Klotho, interleukin 10 (IL-10), IL-1, and oxidative stress in young women with a sedentary lifestyle. Materials and Methods: The present study was a semi-experimental study with a control group. Out of all volunteers, 20 young women eligible to participate in the study were selected and divided into the two groups (n=10) of experimental (i.e., six weeks of moderate-intensity aerobic exercise) and control (i.e., no exercise). Members of the experimental group performed an aerobic exercise program including running on a treadmill with an intensity of 55%-70% of their maximum heart rates (220-age). The running plan started with 50% of their maximum heart rates and reached 70% at the end of the six-week exercise program (three sessions per week). Paired t-test and independent t-test were conducted to examine intra-group and inter-group differences. All statistical procedures were performed using the SPSS version26 statistical package (P≤0.05). Results: At the beginning of the study, no significant difference was observed between the groups in terms of the markers. Six-week aerobic training increased Klotho (mean: 540, lower: 141.5, upper: 938.4) and IL-10 (mean: 0.43, lower: -1.56 upper: -0.47) in experimental group in comparison to control group (P=0.001). Six-week aerobic training decreased IL-1 (mean: 0.78, lower: -1.16 upper: -0.39) and H2O2 (mean: 0.41, lower: -0.96, upper: 0.12) in experimental group in comparison to control group (P=0.001). Conclusions: In sum, six-week moderate-intensity aerobic exercise program increased Klotho and IL-10 levels and decreased IL-1 and oxidative stress levels in young women with a sedentary lifestyle. According to these results, the decrease in oxidative stress and IL-1 levels due to exercise caused an increase in Klotho, and an increase in Klotho level, in turn, increased IL-10.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46929256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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