M. Mohajeranirad, N. Saeidi, M. Kamalinejad, Amir AlmasiHashiani, M. Salehi, S. Latifi
Objectives: 35%-50% of patients with chronic kidney disease (CKD) suffer from anorexia, reducing the quality of life and increasing morbidity and mortality. Its causes and definitive treatment are not fully known. In this study, Avicenna’s management in his medical book "Canon of Medicine" was presented to help solve this problem. Materials and Methods: "Loss of appetite" and its MeSH heading term "anorexia," also "chronic kidney disease," were searched in PubMed, Google Scholar, and UpToDate databases. In Iranian traditional medicine, loss of appetite by "Noghsan-e-shahvat-e-taam", renal weakness by "Zafe-e-kolye", and ascites by "Estesgha" were searched in "Canon of Medicine". Results: According to Avicenna and modern medicine, kidneys play an essential role in normal appetite, and both suggest treatment based on the stage of the disease. Avicenna has described the treatment in 4 principles: lifestyle modification, elimination of waste products accumulated in the body, non-oral therapies, and herbal medicine. He processed food in the diets, which reduces their side effects and improves their digestion, and in the studies conducted, it was in line with the nutritional recommendations of modern medicine. Conclusions: Given the importance of anorexia and no known causes and treatment, Avicenna’s perspective can help solve this problem. He has provided various natural, inexpensive, and accessible solutions that can be the basis for future clinical trials.
{"title":"Approach to Anorexia in Chronic Kidney Disease from Avicenna’s Point of View in Canon of Medicine: A Narrative Review","authors":"M. Mohajeranirad, N. Saeidi, M. Kamalinejad, Amir AlmasiHashiani, M. Salehi, S. Latifi","doi":"10.34172/cjmb.2022.13","DOIUrl":"https://doi.org/10.34172/cjmb.2022.13","url":null,"abstract":"Objectives: 35%-50% of patients with chronic kidney disease (CKD) suffer from anorexia, reducing the quality of life and increasing morbidity and mortality. Its causes and definitive treatment are not fully known. In this study, Avicenna’s management in his medical book \"Canon of Medicine\" was presented to help solve this problem. Materials and Methods: \"Loss of appetite\" and its MeSH heading term \"anorexia,\" also \"chronic kidney disease,\" were searched in PubMed, Google Scholar, and UpToDate databases. In Iranian traditional medicine, loss of appetite by \"Noghsan-e-shahvat-e-taam\", renal weakness by \"Zafe-e-kolye\", and ascites by \"Estesgha\" were searched in \"Canon of Medicine\". Results: According to Avicenna and modern medicine, kidneys play an essential role in normal appetite, and both suggest treatment based on the stage of the disease. Avicenna has described the treatment in 4 principles: lifestyle modification, elimination of waste products accumulated in the body, non-oral therapies, and herbal medicine. He processed food in the diets, which reduces their side effects and improves their digestion, and in the studies conducted, it was in line with the nutritional recommendations of modern medicine. Conclusions: Given the importance of anorexia and no known causes and treatment, Avicenna’s perspective can help solve this problem. He has provided various natural, inexpensive, and accessible solutions that can be the basis for future clinical trials.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43791832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leila Abkhooie, M. Moradi Sarabi, Houman Kahroba, H. Ghanbarian, Soheila Montazer Saheb, Vahideh Tarhriz, M. Hejazi
Objectives: Cyclin-dependent kinases (CDKs) including Cdk9 have been associated with cardiac differentiation. The increasing evidence has proposed that Cdk9 overexpression can regulate the epigenome. However, the current research is the first report of the Cdk9 affection on the regional and global DNA methylation during differentiation. Materials and Methods: This study examined the effects of Cdk9 overexpression on the regional methylation patterns of cardiac miRNAs (miR-1, -133, -206) and myogenic regulatory factors (i.e., MyoD and Myogenin) and promoter DNA methylation in mouse myoblast C2C12 cells during differentiation by the methylation-specific polymerase chain reaction (MSP-PCR) method. Moreover, the mRNA expression levels of DNMT1, DNMT3A, DNMT3B, and global 5-methyl cytosine (5-mC) levels in mouse myoblast C2C12 cells were quantified during differentiation by RT-qPCR and ELISA methods, respectively. Results: The results demonstrated that Cdk9 overexpression results in DNA methylation changes in mouse myoblast C2C12 cells. It was found that the average expression levels of DNMTs in line with global DNA methylation significantly increased in Cdk9 transfected cells upon Cdk9 overexpression (P<0.05). In addition, the results showed that the regional promoter methylation of miR-1 and miR-133 genes increased in transfected cells during differentiation. An interesting possibility raised by our study is that further active global DNA methylation observed in Cdk9-transfected C2C12 cells can be clarified through the increased DNMT expression by Cdk9 in these cells. Conclusions: In general, our study provides a comprehensive mechanism that Cdk9 can promote epigenetic changes and modulate global and regional DNA methylation profiling of myoblast cells during differentiation.
{"title":"Cyclin-dependent Kinase 9 Induces Regional and Global Genomic DNA Methylation Via Influencing DNMT Gene Expression in Mouse Myoblast C2C12 Cells During Differentiation","authors":"Leila Abkhooie, M. Moradi Sarabi, Houman Kahroba, H. Ghanbarian, Soheila Montazer Saheb, Vahideh Tarhriz, M. Hejazi","doi":"10.34172/cjmb.2022.05","DOIUrl":"https://doi.org/10.34172/cjmb.2022.05","url":null,"abstract":"Objectives: Cyclin-dependent kinases (CDKs) including Cdk9 have been associated with cardiac differentiation. The increasing evidence has proposed that Cdk9 overexpression can regulate the epigenome. However, the current research is the first report of the Cdk9 affection on the regional and global DNA methylation during differentiation. Materials and Methods: This study examined the effects of Cdk9 overexpression on the regional methylation patterns of cardiac miRNAs (miR-1, -133, -206) and myogenic regulatory factors (i.e., MyoD and Myogenin) and promoter DNA methylation in mouse myoblast C2C12 cells during differentiation by the methylation-specific polymerase chain reaction (MSP-PCR) method. Moreover, the mRNA expression levels of DNMT1, DNMT3A, DNMT3B, and global 5-methyl cytosine (5-mC) levels in mouse myoblast C2C12 cells were quantified during differentiation by RT-qPCR and ELISA methods, respectively. Results: The results demonstrated that Cdk9 overexpression results in DNA methylation changes in mouse myoblast C2C12 cells. It was found that the average expression levels of DNMTs in line with global DNA methylation significantly increased in Cdk9 transfected cells upon Cdk9 overexpression (P<0.05). In addition, the results showed that the regional promoter methylation of miR-1 and miR-133 genes increased in transfected cells during differentiation. An interesting possibility raised by our study is that further active global DNA methylation observed in Cdk9-transfected C2C12 cells can be clarified through the increased DNMT expression by Cdk9 in these cells. Conclusions: In general, our study provides a comprehensive mechanism that Cdk9 can promote epigenetic changes and modulate global and regional DNA methylation profiling of myoblast cells during differentiation.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42339650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The present study was designed to evaluate and compare the screening markers of spontaneous and in vitro fertilization (IVF) pregnancies in individuals who underwent combined screening in the first trimester of pregnancy. Materials and Methods: In this retrospective study, we examined the difference between natural and assisted-reproductive technology (ART) pregnancies in 2252 mothers from January 2011 to October 2019. In both groups, the first trimester screening parameters including NT, free beta-human chorionic gonadotropin (β-hCG), and PAPP-A were measured. Results: According to the results of the present study, BMI was higher in the group that became pregnant by IVF compared to the normal pregnancy group (P<0.001). Additionally, in patients using IVF, the history of maternal disease was less frequent compared to the other group (P=0.003). Most cases of twin fetuses, dichorionic twin pregnancy, and fetal abnormality were seen in the IVF group. Although the β-hCG and free PAPP-A levels were high in the IVF group, no significant difference was observed. The group with spontaneous pregnancy had a higher penetration rate of nuchal translucency <95th percentile compared to the IVF group (P<0.001). The results of comparing the first trimester test showed that in the IVF group, 81.3% of patients were at low risk and 6.6% were at high risk, while in the normal pregnancy group, 78.9% of patients were at low risk and 7.0% of them were at low risk, indicating that the difference was not significant. Conclusions: Overall, although the risk of aneuploidy in IVF pregnancies was not higher compared to normal pregnancies, in IVF pregnancies, NI is associated with a high risk of fetal abnormalities. Therefore, NT sonography can help to diagnose fetal anomalies especially aneuploidy
{"title":"Comparison of First-Trimester Screening Biomarkers in Spontaneous (Natural) and In Vitro Fertilization Pregnancies","authors":"M. Barati, M. Zargar, B. Asan","doi":"10.34172/cjmb.2022.19","DOIUrl":"https://doi.org/10.34172/cjmb.2022.19","url":null,"abstract":"Objectives: The present study was designed to evaluate and compare the screening markers of spontaneous and in vitro fertilization (IVF) pregnancies in individuals who underwent combined screening in the first trimester of pregnancy. Materials and Methods: In this retrospective study, we examined the difference between natural and assisted-reproductive technology (ART) pregnancies in 2252 mothers from January 2011 to October 2019. In both groups, the first trimester screening parameters including NT, free beta-human chorionic gonadotropin (β-hCG), and PAPP-A were measured. Results: According to the results of the present study, BMI was higher in the group that became pregnant by IVF compared to the normal pregnancy group (P<0.001). Additionally, in patients using IVF, the history of maternal disease was less frequent compared to the other group (P=0.003). Most cases of twin fetuses, dichorionic twin pregnancy, and fetal abnormality were seen in the IVF group. Although the β-hCG and free PAPP-A levels were high in the IVF group, no significant difference was observed. The group with spontaneous pregnancy had a higher penetration rate of nuchal translucency <95th percentile compared to the IVF group (P<0.001). The results of comparing the first trimester test showed that in the IVF group, 81.3% of patients were at low risk and 6.6% were at high risk, while in the normal pregnancy group, 78.9% of patients were at low risk and 7.0% of them were at low risk, indicating that the difference was not significant. Conclusions: Overall, although the risk of aneuploidy in IVF pregnancies was not higher compared to normal pregnancies, in IVF pregnancies, NI is associated with a high risk of fetal abnormalities. Therefore, NT sonography can help to diagnose fetal anomalies especially aneuploidy","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44599569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ghaffari, Shirin Forooghifar, Mohammad Naghavi Behzad, Nazila Karzad, Khazar Ghasempour Dabaghi, R. Piri, M. Moradian, Roghaye Nasiri, Razieh Parizad, A. Tajlil
Objectives: Despite the importance of congenital heart disease (CHD) in the population, the risk factors predisposing infants to be born with non-syndromic CHD are not well understood yet. Materials and Methods: In a case-control study, we recruited consecutive 109 infants with non-syndromic CHD who were referred to our pediatric cardiac care clinic and then compared them with 117 infants without CHD (2015-2016). Paternal, maternal, and neonatal demographic information, maternal past medical history, and antenatal history were recorded for each child. To investigate the potential risk factors for developing CHD, infants with and without CHD were compared in terms of study variables. In a second analysis, preterm infants were excluded and term infants were compared regarding the study variables. Results: The findings revealed that higher maternal and paternal education were both associated with a lower risk of CHD (odds ratio [OR]: 0.47, 95% confidence interval [CI]: 0.24-0.93, P=0.031, and OR: 0.45, 95% CI: 0.23-0.89, P=0.023, respectively). The family history of CHD in the first- or second-degree relatives of infants was significantly associated with CHD (OR: 3.56, 95% CI: 1.35-9.40, P=0.007). Several parameters were more prevalent in the CHD group, including having lower birth weight, having preterm birth, being the fourth birth order or higher, and not receiving maternity care under the supervision of a gynecologist. However, higher birth order and lower birth weight were not associated with CHD in exclusively term infants. Finally, a higher maternal educational level was related to lower CHD in term infants even after adjusting for a family history of CHD and preconception diabetes mellitus (OR: 5.45, 95% CI: 1.71-17.37, P=0.004). Conclusions: Our study findings demonstrate the need for a more enhanced primary care program, especially in patients with poor financial status and a family history of CHD.
{"title":"The Predisposing Risk Factors for Non-syndromic Congenital Heart Disease: A Case-Control Study","authors":"S. Ghaffari, Shirin Forooghifar, Mohammad Naghavi Behzad, Nazila Karzad, Khazar Ghasempour Dabaghi, R. Piri, M. Moradian, Roghaye Nasiri, Razieh Parizad, A. Tajlil","doi":"10.34172/cjmb.2022.26","DOIUrl":"https://doi.org/10.34172/cjmb.2022.26","url":null,"abstract":"Objectives: Despite the importance of congenital heart disease (CHD) in the population, the risk factors predisposing infants to be born with non-syndromic CHD are not well understood yet. Materials and Methods: In a case-control study, we recruited consecutive 109 infants with non-syndromic CHD who were referred to our pediatric cardiac care clinic and then compared them with 117 infants without CHD (2015-2016). Paternal, maternal, and neonatal demographic information, maternal past medical history, and antenatal history were recorded for each child. To investigate the potential risk factors for developing CHD, infants with and without CHD were compared in terms of study variables. In a second analysis, preterm infants were excluded and term infants were compared regarding the study variables. Results: The findings revealed that higher maternal and paternal education were both associated with a lower risk of CHD (odds ratio [OR]: 0.47, 95% confidence interval [CI]: 0.24-0.93, P=0.031, and OR: 0.45, 95% CI: 0.23-0.89, P=0.023, respectively). The family history of CHD in the first- or second-degree relatives of infants was significantly associated with CHD (OR: 3.56, 95% CI: 1.35-9.40, P=0.007). Several parameters were more prevalent in the CHD group, including having lower birth weight, having preterm birth, being the fourth birth order or higher, and not receiving maternity care under the supervision of a gynecologist. However, higher birth order and lower birth weight were not associated with CHD in exclusively term infants. Finally, a higher maternal educational level was related to lower CHD in term infants even after adjusting for a family history of CHD and preconception diabetes mellitus (OR: 5.45, 95% CI: 1.71-17.37, P=0.004). Conclusions: Our study findings demonstrate the need for a more enhanced primary care program, especially in patients with poor financial status and a family history of CHD.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47226634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Aortic stenosis (AS) is a common valvular disease diagnosed in nearly 3% of adults who are older than 65 years. Echocardiography is the main modality for the diagnosis of an AS. The left atrial (LA) strain can help in a better evaluation of heart failure and predict left-side pressures. Considering that a left ventricular ejection fraction (LVEF) is an important factor for cardiologists regarding better selection of surgery treatment in these patients, the evaluation of the LA strain and LVEF, as well as their association can help physicians in a better evaluation of borderline patients who are asymptomatic with borderline LVEF. Materials and Methods: Atrial mechanics were prospectively evaluated in 43 consecutive patients with severe AS referring to Shahid Rajaee Heart Center (Tehran, Iran), echocardiography laboratory for their regular valve disease follow-ups from July 2018 to February 2019. The LA strain, the LVEF, and their association were analyzed by a 3D heart model. Results: The mean age of patients was 56.6±18.9 years. The LA strain did not have any association with age (P=0.09). In addition, no association was found among LA strains, hypertension, and smoking in patients with severe AS (P>0.05). Finally, the results showed that an LA strain had a significant association with a 3D method of LVEF (P=0.02). Conclusions: In general, an LA longitudinal strain has a significant association with a 3D LVEF in patients with severe AS and can help physicians better evaluate patients with severe AS.
{"title":"The Association Between Left Atrial Strain and Left Ventricular Ejection Fraction in a 3D Heart Model in Patients With Severe Aortic Stenosis","authors":"Kamran Mohammadi, A. Alizadehasl, Mehrdad Jafari Fesharaki, Reza Hajizadeh, Farshad Javadieh","doi":"10.34172/cjmb.2022.18","DOIUrl":"https://doi.org/10.34172/cjmb.2022.18","url":null,"abstract":"Objectives: Aortic stenosis (AS) is a common valvular disease diagnosed in nearly 3% of adults who are older than 65 years. Echocardiography is the main modality for the diagnosis of an AS. The left atrial (LA) strain can help in a better evaluation of heart failure and predict left-side pressures. Considering that a left ventricular ejection fraction (LVEF) is an important factor for cardiologists regarding better selection of surgery treatment in these patients, the evaluation of the LA strain and LVEF, as well as their association can help physicians in a better evaluation of borderline patients who are asymptomatic with borderline LVEF. Materials and Methods: Atrial mechanics were prospectively evaluated in 43 consecutive patients with severe AS referring to Shahid Rajaee Heart Center (Tehran, Iran), echocardiography laboratory for their regular valve disease follow-ups from July 2018 to February 2019. The LA strain, the LVEF, and their association were analyzed by a 3D heart model. Results: The mean age of patients was 56.6±18.9 years. The LA strain did not have any association with age (P=0.09). In addition, no association was found among LA strains, hypertension, and smoking in patients with severe AS (P>0.05). Finally, the results showed that an LA strain had a significant association with a 3D method of LVEF (P=0.02). Conclusions: In general, an LA longitudinal strain has a significant association with a 3D LVEF in patients with severe AS and can help physicians better evaluate patients with severe AS.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2020-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47134983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hamed Ashrafzadeh Takhtfooladi, P. Mortazavi, A. Asghari, F. Moayer
Objectives: The aim of the current study was to assess the effects of hesperetin on damage to kidneys as remote organs following skeletal muscle ischemia-reperfusion (IR) in rats. Materials and Methods: In general, 30 male Wistar rats were randomized and placed into sham, IR, hesperetin, dimethyl sulfoxide (DMSO), and IR+hesperetin groups. The rats in the hesperetin and IR+hesperetin groups received a 50 mg/kg dose of hesperetin dissolved in DMSO intraperitoneally. In the IR+hesperetin group, hesperetin was injected exactly prior to reperfusion. To induce skeletal muscle ischemia, the femoral artery was clamped for two hours. Following a 24-hour period of reperfusion, the samples of blood were collected for renal function tests and oxidative stress measurements. Next, the rats were euthanized, and histological analyses were conducted on their removed kidneys. Results: Based on the results, urea and creatinine serum levels were significantly higher in the IR group (P<0.05) whereas they significantly reduced following treatment with hesperetin (P<0.05). The concentration of malondialdehyde (P<0.05) increased for the IR group while those of superoxide dismutase (P<0.05) and glutathione peroxidase (P<0.05) activities were lower than the other groups. The analysis of renal tissues in the IR group showed glomerular necrosis, degeneration, and necrosis of the tubular epithelium, protein casts, interstitial edema, and inflammation. Finally, the degree of renal injury was significantly ameliorated (P<0.05) in rats treated with hesperetin. Conclusions: Overall, the results indicated that in rats, hesperetin could reduce renal injury that has been induced through skeletal muscle IR.
{"title":"Effects of Hesperetin on the Serum Superoxide Dismutase, Glutathione Peroxidase, and Malondialdehyde Levels and Renal-Histopathological Alterations Following Skeletal Muscle Ischemia Reperfusion in Male Rats","authors":"Hamed Ashrafzadeh Takhtfooladi, P. Mortazavi, A. Asghari, F. Moayer","doi":"10.34172/cjmb.2022.04","DOIUrl":"https://doi.org/10.34172/cjmb.2022.04","url":null,"abstract":"Objectives: The aim of the current study was to assess the effects of hesperetin on damage to kidneys as remote organs following skeletal muscle ischemia-reperfusion (IR) in rats. Materials and Methods: In general, 30 male Wistar rats were randomized and placed into sham, IR, hesperetin, dimethyl sulfoxide (DMSO), and IR+hesperetin groups. The rats in the hesperetin and IR+hesperetin groups received a 50 mg/kg dose of hesperetin dissolved in DMSO intraperitoneally. In the IR+hesperetin group, hesperetin was injected exactly prior to reperfusion. To induce skeletal muscle ischemia, the femoral artery was clamped for two hours. Following a 24-hour period of reperfusion, the samples of blood were collected for renal function tests and oxidative stress measurements. Next, the rats were euthanized, and histological analyses were conducted on their removed kidneys. Results: Based on the results, urea and creatinine serum levels were significantly higher in the IR group (P<0.05) whereas they significantly reduced following treatment with hesperetin (P<0.05). The concentration of malondialdehyde (P<0.05) increased for the IR group while those of superoxide dismutase (P<0.05) and glutathione peroxidase (P<0.05) activities were lower than the other groups. The analysis of renal tissues in the IR group showed glomerular necrosis, degeneration, and necrosis of the tubular epithelium, protein casts, interstitial edema, and inflammation. Finally, the degree of renal injury was significantly ameliorated (P<0.05) in rats treated with hesperetin. Conclusions: Overall, the results indicated that in rats, hesperetin could reduce renal injury that has been induced through skeletal muscle IR.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44670734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mina Hosseini, Manijeh Mostafa Gharebaghi, M. Bagheri, Sadollah Yeganehdoost, Amir Eftekhari Milani, M. Niyousha
Objectives: Due to recent advances in caring for premature neonates, premature retinopathy has become an important cause of preventable blindness and ocular disabilities. Therefore, more attention is paying to its diagnostic-therapeutic methods. Thus, the current trial assessed the efficacy of oral propranolol on the treatment of retinopathy of prematurity (ROP) in neonates. Materials and Methods: In the current trial, 58 neonates with ROP were included and the efficacy of oral propranolol (0.5 mg/kg every 8 hours) was compared with the control group. Results: In the intervention group, the stage of ROP was almost the same as the control group while 31.1% of neonates in the control group were progressed to stage 3. On the other hand, it was only 6.9% (P=0.009) in the intervention group. In patients receiving propranolol, only 2 cases required invasive therapeutic interventions whereas 9 patients required such interventions in the control group (P=0.009). The ROP improvement rate was significantly higher in the intervention group. In the control group, the overall progression to higher stages was about 48.3% while it was 13.8% for the intervention group. The mean age of neonates at the time of retinal artery completion was 91.40±22.16 and 128.08±79.89 days for the control and intervention groups, respectively (P=0.136). Conclusions: The results of this study showed that adding oral propranolol to standard therapy can reduce the rate of ROP progression to higher stages in preterm neonates with low birth weight, and the need for invasive treatments.
{"title":"Efficacy of Oral Propranolol on the Treatment of Retinopathy of Prematurity","authors":"Mina Hosseini, Manijeh Mostafa Gharebaghi, M. Bagheri, Sadollah Yeganehdoost, Amir Eftekhari Milani, M. Niyousha","doi":"10.34172/cjmb.2022.10","DOIUrl":"https://doi.org/10.34172/cjmb.2022.10","url":null,"abstract":"Objectives: Due to recent advances in caring for premature neonates, premature retinopathy has become an important cause of preventable blindness and ocular disabilities. Therefore, more attention is paying to its diagnostic-therapeutic methods. Thus, the current trial assessed the efficacy of oral propranolol on the treatment of retinopathy of prematurity (ROP) in neonates. Materials and Methods: In the current trial, 58 neonates with ROP were included and the efficacy of oral propranolol (0.5 mg/kg every 8 hours) was compared with the control group. Results: In the intervention group, the stage of ROP was almost the same as the control group while 31.1% of neonates in the control group were progressed to stage 3. On the other hand, it was only 6.9% (P=0.009) in the intervention group. In patients receiving propranolol, only 2 cases required invasive therapeutic interventions whereas 9 patients required such interventions in the control group (P=0.009). The ROP improvement rate was significantly higher in the intervention group. In the control group, the overall progression to higher stages was about 48.3% while it was 13.8% for the intervention group. The mean age of neonates at the time of retinal artery completion was 91.40±22.16 and 128.08±79.89 days for the control and intervention groups, respectively (P=0.136). Conclusions: The results of this study showed that adding oral propranolol to standard therapy can reduce the rate of ROP progression to higher stages in preterm neonates with low birth weight, and the need for invasive treatments.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2020-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49486740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Hafizi, M. Amirian, Seyedeh Azam Pourhoseini, Akram Behrouznia, M. Baradaran
Objectives: The aim of this study was to evaluate the rate and severity of intrauterine adhesions (IUAs) and their association with septum morphology following the hysteroscopic resection of the uterine septum. Materials and Methods: This cross-sectional study was conducted on patients with septate uteri undergoing hysteroscopic septolysis with scissors. Two months after the surgery, the second look hysteroscopy was performed and the intrauterine cavity was evaluated for IUAs and residual septum. Afterward, the rate and severity of adhesions and residual septum and their association with the septal morphology were studied as well. Results: In general, 30 patients were entered into the study. The incidence rate of adhesions following septoplasty was 23.3%. It was mild and moderate in 16.7% and 6.7%, respectively. The incidence rate of adhesions was not related to the length and width of the septum (P=0.281, P=0.495). The rate of the residual septum in second-look hysteroscopy was 56.7%, which was less than 0.5 cm in most cases (33.3%). It was not more than 1 cm in any case. The possibility of the residual septum was significantly higher in long septa (P=0.045) whereas it was not related to the septum width (P=0.087). Conclusions: IUA following hysteroscopic septolysis is a possibility, especially in infertile patients which is often mild. The presence of a uterine factor in such patients may justify the risk of increased IUAs in our study in comparison to others. Therefore, it is able to perform second-look hysteroscopy in infertile patients with a septate uterus for the diagnosis and early treatment of IUAs.
{"title":"Evaluation of Intrauterine Adhesion After Hysteroscopic Resection of Uterine Septum","authors":"L. Hafizi, M. Amirian, Seyedeh Azam Pourhoseini, Akram Behrouznia, M. Baradaran","doi":"10.34172/cjmb.2022.09","DOIUrl":"https://doi.org/10.34172/cjmb.2022.09","url":null,"abstract":"Objectives: The aim of this study was to evaluate the rate and severity of intrauterine adhesions (IUAs) and their association with septum morphology following the hysteroscopic resection of the uterine septum. Materials and Methods: This cross-sectional study was conducted on patients with septate uteri undergoing hysteroscopic septolysis with scissors. Two months after the surgery, the second look hysteroscopy was performed and the intrauterine cavity was evaluated for IUAs and residual septum. Afterward, the rate and severity of adhesions and residual septum and their association with the septal morphology were studied as well. Results: In general, 30 patients were entered into the study. The incidence rate of adhesions following septoplasty was 23.3%. It was mild and moderate in 16.7% and 6.7%, respectively. The incidence rate of adhesions was not related to the length and width of the septum (P=0.281, P=0.495). The rate of the residual septum in second-look hysteroscopy was 56.7%, which was less than 0.5 cm in most cases (33.3%). It was not more than 1 cm in any case. The possibility of the residual septum was significantly higher in long septa (P=0.045) whereas it was not related to the septum width (P=0.087). Conclusions: IUA following hysteroscopic septolysis is a possibility, especially in infertile patients which is often mild. The presence of a uterine factor in such patients may justify the risk of increased IUAs in our study in comparison to others. Therefore, it is able to perform second-look hysteroscopy in infertile patients with a septate uterus for the diagnosis and early treatment of IUAs.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45397216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Patent ductus arteriosus (PDA) is one of the most common congenital heart diseases. Physiologically, the closure of the ductus arteriosus occurs within 48-72 hours after birth in healthy term neonates. This study aimed to compare oral paracetamol and oral ibuprofen in the closure of PDA in preterm neonates. Materials and Methods: This study is a single-blind randomized clinical trial. A total of 90 preterm neonates with a gestational age of less than 32 weeks were divided into two groups of oral ibuprofen and oral paracetamol. Oral ibuprofen was administered at a dose of 10 mg/kg on the first day and 5 mg/kg on the second and the third days. Oral paracetamol was administered at a dose of 10 mg/kg every 6 hours for 3 consecutive days. The primary outcome measure was the closure of the ductus arteriosus. The secondary outcome measure was the assessment of any type of complications following the administration of oral paracetamol. Results: The DA closure rate was 82.2% in the oral paracetamol group and it was 91.41% in the oral ibuprofen group P<0.65, (odds ratio [OR] = 2.22, 95% CI = 0.62-7.97). We did not see any unwanted complication during treatment with oral paracetamol. Conclusions: The present study showed that oral paracetamol is effective in the closure of PDA. On the other hand, it does not cause any unwanted side effects on the patient.
{"title":"Comparison of Oral Paracetamol with Oral Ibuprofen in Closing Patent Ductus Arteriosus in Premature Neonates: A Randomized Controlled Trial","authors":"Mahmoud Samadi, K. Mirnia, Zahra Nabaie, Armin Salek Maghsoudi, Reza Aliakbari Khoei, Razieh Parizad","doi":"10.34172/cjmb.2022.17","DOIUrl":"https://doi.org/10.34172/cjmb.2022.17","url":null,"abstract":"Objectives: Patent ductus arteriosus (PDA) is one of the most common congenital heart diseases. Physiologically, the closure of the ductus arteriosus occurs within 48-72 hours after birth in healthy term neonates. This study aimed to compare oral paracetamol and oral ibuprofen in the closure of PDA in preterm neonates. Materials and Methods: This study is a single-blind randomized clinical trial. A total of 90 preterm neonates with a gestational age of less than 32 weeks were divided into two groups of oral ibuprofen and oral paracetamol. Oral ibuprofen was administered at a dose of 10 mg/kg on the first day and 5 mg/kg on the second and the third days. Oral paracetamol was administered at a dose of 10 mg/kg every 6 hours for 3 consecutive days. The primary outcome measure was the closure of the ductus arteriosus. The secondary outcome measure was the assessment of any type of complications following the administration of oral paracetamol. Results: The DA closure rate was 82.2% in the oral paracetamol group and it was 91.41% in the oral ibuprofen group P<0.65, (odds ratio [OR] = 2.22, 95% CI = 0.62-7.97). We did not see any unwanted complication during treatment with oral paracetamol. Conclusions: The present study showed that oral paracetamol is effective in the closure of PDA. On the other hand, it does not cause any unwanted side effects on the patient.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46504920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Yousefi, Roshanak Mokaberi Nejad, M. Tansaz, Soodabeh Bioos, Z. Hamzehgardeshi
Objectives: This review investigates the existing research with regard to a variety of different suggested methods by traditional Persian medicine (TPM) about the baby’s sex selection. Materials and Methods: A comprehensive scoping review including five stages was conducted to summarize evidence on pre-implantation sex selection in TPM. The research question and relevant studies were identified in stages 1 and 2, respectively. Then, studies were selected and data were charted in stages 3 and 4, and finally, the results were collated, summarized, and reported in stage 5. Results: Accordingly, 7 general categories were arranged, including the temperament of the sexual organs in a man, the temperament of sexual organs in a woman, the type of male semen, and timing and manner of sexual intercourse for fetus sex induction purposes. Other categories were the effect of environmental factors, the couple’s psychic states during the course of love-making, the couple’s age, and measures for male sex induction. Conclusions: This review summarizes the existing research regarding different suggested methods by TPM on the baby’s sex selection. These could well be the basis for further prospective scientific research and investigation.
{"title":"Preconception Sex Selection in Traditional Persian Medicine: A Review of the Literature","authors":"S. Yousefi, Roshanak Mokaberi Nejad, M. Tansaz, Soodabeh Bioos, Z. Hamzehgardeshi","doi":"10.34172/cjmb.2022.02","DOIUrl":"https://doi.org/10.34172/cjmb.2022.02","url":null,"abstract":"Objectives: This review investigates the existing research with regard to a variety of different suggested methods by traditional Persian medicine (TPM) about the baby’s sex selection. Materials and Methods: A comprehensive scoping review including five stages was conducted to summarize evidence on pre-implantation sex selection in TPM. The research question and relevant studies were identified in stages 1 and 2, respectively. Then, studies were selected and data were charted in stages 3 and 4, and finally, the results were collated, summarized, and reported in stage 5. Results: Accordingly, 7 general categories were arranged, including the temperament of the sexual organs in a man, the temperament of sexual organs in a woman, the type of male semen, and timing and manner of sexual intercourse for fetus sex induction purposes. Other categories were the effect of environmental factors, the couple’s psychic states during the course of love-making, the couple’s age, and measures for male sex induction. Conclusions: This review summarizes the existing research regarding different suggested methods by TPM on the baby’s sex selection. These could well be the basis for further prospective scientific research and investigation.","PeriodicalId":43540,"journal":{"name":"Crescent Journal of Medical and Biological Sciences","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2020-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49523478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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