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Race and the Cultures of Transcendental Reform 种族与超越改革的文化
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0003
David Faflik
From the time of its emergence in New England in the early 1830s, Transcendentalism often proved unintelligible to the uninitiated, who were unsure what to make of its heady mixture of liberal spiritual renewal, German philosophic idealism, and progressive social reform. Area divines like the Cambridge-based Unitarian theologian Andrews Norton responded to the challenge posed to his religion by the Transcendentalist worldview by naming it “the latest form of infidelity.” Those who were inclined to caricaturize meanwhile set about establishing the stereotype (which retains its appeal in the popular imagination today) of the Transcendentalists as an insular cohort of young, white, mostly middle-class regional intellectuals whose deep reading in period Continental thought and English and European Romanticism rendered them a feckless band of starry-eyed dreamers, ill-equipped for active involvement in the world. Indeed, despite the subsequent canonization in the United States of such celebrated Transcendentalist stalwarts as Ralph Waldo Emerson, Henry David Thoreau, Margaret Fuller, and Theodore Parker, a largely fictional portrayal of the Transcendentalists as abstracted and detached has had surprising staying power. Author Nathaniel Hawthorne epitomized a contemporary trend in Transcendentalist satire with his novel The Blithedale Romance (1852); the roman à clef narrative contained therein reads less as an objective depiction of the famous Brook Farm experiment in communal living in which Hawthorne himself participated than it does a seriocomic sendup of a Transcendentalistled enterprise that figures as ridiculous on the page. Even recent critics of a cultural phenomenon that qualifies more as a historical moment than a full-fledged movement have found it hard to resist the too-easy dismissal of Transcendentalism as an esoteric afterthought to the rough and tumble realities of antebellum America. Writing of what he calls the “politics” of classic American literature, for example, John Carlos
自19世纪30年代初在新英格兰出现以来,超验主义经常被证明是外行所无法理解的,他们不确定如何看待其自由主义精神复兴、德国哲学理想主义和进步社会改革的令人兴奋的混合体。剑桥一神教神学家安德鲁斯·诺顿等地区神学家回应了超验主义世界观对其宗教提出的挑战,称其为“最新形式的不忠”。“与此同时,那些倾向于讽刺的人开始建立超验主义者的刻板印象(在今天的大众想象中仍然保持着吸引力),他们是一批孤立的年轻白人,大多是中产阶级的地区知识分子,他们对大陆思想、英国和欧洲浪漫主义的深入阅读使他们成为一群无能的、充满幻想的梦想家,没有能力积极参与世界事务。事实上,尽管随后拉尔夫·沃尔多·爱默生、亨利·大卫·梭罗、玛格丽特·富勒和西奥多·帕克等著名的超验主义坚定分子在美国被封为圣徒,但对超验主义者抽象和超然的虚构刻画却具有惊人的持久力。作家纳撒尼尔·霍桑(Nathaniel Hawthorne)的小说《极乐罗曼史》(The Blithedale Romance,1852)集中体现了超验主义讽刺的当代潮流;其中包含的罗马字母叙事与其说是对霍桑本人参与的著名的布鲁克农场社区生活实验的客观描述,不如说是对一个在页面上被视为荒谬的超验主义企业的系列模仿。即使是最近对一种文化现象的批评,这种现象更像是一个历史时刻,而不是一场全面的运动,也发现很难抗拒对超验主义的过于轻易的否定,认为它是对南北战争前美国混乱现实的一种深奥的事后思考。他称之为美国经典文学中的“政治”,例如约翰·卡洛斯
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引用次数: 0
Unmasking the Peaceful Atom 揭开和平原子的面纱
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0010
J. Krige
The peaceful atom is a thick historical object. Its analysis covers a range of material practices from exploiting radioisotopes for agriculture, medicine, and biomedical research to constructing and operating nuclear power reactors for research and to generate electricity. Although the social benefits of the atom predated WWII, it was the horror of nuclear war, as evidenced in August 1945, that propelled the exploitation of the peaceful atom to the core of the political process. Actively promoted as a benign alternative to atoms for war, the dissemination of the fruits of the peaceful atom, with the cooperation of industry, became entangled with interstate competition, superpower rivalry and the wave of decolonization that began to sweep across the globe in the late 1940s. Its attraction was catalyzed by President Eisenhower’s famous ‘Atoms for Peace’ speech at the United Nations in December 1953. Eisenhower was stung by a rising crescendo of criticism of the U.S. for developing and testing both atomic and hydrogen bombs. In a determined attempt “to convince the world that we are working for peace and not trying to blow them to kingdom come,”1 the President announced that his government would work along with others to make fissionable material available to those who wanted “to apply atomic energy to the needs of agriculture, medicine and other peaceful activities” and, most notably, to the provision of “abundant electrical energy in the power-starved areas of the world.”2 The enthusiastic response to this suggestion provided the impetus for a revision of the 1946 Atomic Energy Act in 1954 to facilitate the exchange of information with other nations and the commercialization of nuclear energy by private industry. Eisenhower’s speech was the backdrop to two major international conferences on the peaceful uses of atomic energy in Geneva in 1955 and 1958.3 And it led to the establishment of an International Atomic Energy Agency (IAEA) under UN auspices to promote the exploitation of the peaceful atom and to implement safeguards against a nuclear power program being diverted from civil to military objectives. By the time the decade was out, the U.S. Atomic Energy Commission
和平原子是一件厚重的历史物品。它的分析涵盖了从为农业、医学和生物医学研究开发放射性同位素到为研究和发电建造和运行核动力反应堆的一系列材料实践。虽然原子的社会效益早在第二次世界大战之前就出现了,但正如1945年8月所证明的那样,正是核战争的恐怖推动了和平利用原子成为政治进程的核心。在工业的合作下,和平原子成果的传播作为一种良性替代品被积极推广,与国家间竞争、超级大国的对抗以及20世纪40年代末开始席卷全球的非殖民化浪潮纠缠在一起。1953年12月,艾森豪威尔总统在联合国发表了著名的“原子用于和平”演讲,促进了它的吸引力。对美国发展和试验原子弹和氢弹的批评日益高涨,令艾森豪威尔感到震惊。为了“让全世界相信我们是在为和平而努力,而不是试图把他们炸到天荒地老”,总统宣布,他的政府将与其他国家一道,向那些希望“将原子能应用于农业、医药和其他和平活动”的国家提供可裂变材料,最值得注意的是,向“世界上缺电的地区提供充足的电能”。“2 .对这一建议的热烈反应推动了1954年对1946年原子能法的修订,以促进与其他国家的信息交流和私营工业对核能的商业化。艾森豪威尔的演讲是1955年和1958年在日内瓦举行的两次关于和平利用原子能的重要国际会议的背景,并导致在联合国主持下成立了国际原子能机构(IAEA),以促进和平利用原子能,并实施保障措施,防止核能项目从民用转向军事目的。十年后,美国原子能委员会
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引用次数: 0
The Not-So-Puritan Origins of the American Self 美国自我的非清教徒起源
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0001
Gideon A. Mailer
Twenty years ago, while I was studying at Cambridge University, my accommodation overlooked a college chapel that had once been a victim of Puritan iconoclasm. The chapel of Peterhouse was consecrated in 1633 by supporters of Archbishop William Laud and his Beauty of Holiness movement. Unsurprisingly, its quirky Renaissance-Gothic synthesis did not appeal to the thousands of Parliamentary troops who were quartered in Cambridge during the English Civil Wars, nor the newly appointed “Commissioner for the destruction of monuments of idolatry and superstition” for the Eastern Association, William Dowsing (1596–1668). Though Dowsing succeeded in removing statues of angels and cherubs from the chapel in 1643, High-Church-leaning Peterhouse fellows managed to hide the Flemish stained-glass panel that depicted Rubens’s Le Coup de Lance, which they reinstalled after the restoration of the Stuart royal line in 1660.1 Ten years after gazing at that chapel roof, during my two-day campus interview for a job at the University of Minnesota, I included its iconoclastic story in my response to a question from a search committee member. I had been discussing how the 1707 Act of Union between the English and Scottish parliaments had created a bi-confessional British state, which provided a model of jurisdictional pluralism for dissenting Protestants in North America. But the professor asked me to rewind one century to consider how the 1603 Regal Union between the English and Scottish monarchies might also help us to understand the origins of religious pluralism in colonial North America and the nascent United States. I used the chapel story to illustrate a warning that I offered to students: be careful mining seventeenth-century Anglo-Scottish history for the disestablishmentarian roots of British imperial life and American religious pluralism, or even the notion that multiple religious establishments might cohere within a single political union. As demonstrated by the deployment of authority by William Dowsing, iconoclastic Puritans shared a tendency for
20年前,当我在剑桥大学学习时,我的住处俯瞰着一座大学小教堂,这座教堂曾经是清教徒破坏圣像的受害者。彼得豪斯小教堂于1633年由大主教威廉·劳德及其“圣洁之美”运动的支持者祝圣。不出所料,它奇特的文艺复兴哥特式风格并没有吸引英国内战期间驻扎在剑桥的数千名议会军,也没有吸引新任命的东方协会“偶像崇拜和迷信纪念碑销毁专员”威廉·道辛(1596-1668)。尽管道辛在1643年成功地将天使和小天使的雕像从小教堂移走,但倾向于高级教堂的彼得豪斯研究员们还是设法隐藏了描绘鲁本斯的《兰斯政变》的佛兰德彩色玻璃板,他们在1660.1年斯图亚特皇室线修复后重新安装了该玻璃板,在明尼苏达大学为期两天的求职面试中,我在回答一位求职委员会成员的问题时,将其打破传统的故事写进了我的回答中。我一直在讨论1707年英国和苏格兰议会之间的《联合法案》是如何建立一个双教派的英国国家的,它为北美持不同意见的新教徒提供了一个管辖多元化的模式。但这位教授让我倒退一个世纪,思考1603年英国和苏格兰君主制之间的君主制联盟如何也能帮助我们理解殖民地北美和新生美国宗教多元化的起源。我用小教堂的故事来说明我向学生们提出的一个警告:要小心挖掘17世纪英国-苏格兰的历史,寻找英国帝国生活和美国宗教多元主义的不稳定根源,甚至是多个宗教机构可能在一个政治联盟中合一的概念。正如威廉·道辛的权威部署所表明的那样,反传统的清教徒有一种共同的倾向
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引用次数: 0
High Infidelity 高度不忠
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0000
C. Heyrman
He was a daring fellow, they all agreed. A damned daring infidel, old Tom Paine. Of course, not all would go his distance, take his risks, and reason their way into his radical deism. But at least one among them did. Young Abraham Lincoln would echo Paine to engage—maybe to impress—the company of men who gathered at New Salem’s general store in frontier Illinois. He would point out contradictions in the Bible and ridicule those passages that beggared belief. He even composed “a little book on Infidelity” modeled on Paine’s Age of Reason, and in its pages he dismissed the virgin birth, Christ’s miracles, and his resurrection. As for the clergy, he shared Paine’s contempt: a scheming bunch, bent on gaining money and power by scaring their credulous flocks. Strong words, the men of New Salem nodded, but they had to wonder: would that damned daring infidel Lincoln ever regret flapping his gums? Strictly speaking, the Lincoln of the 1830s, like Paine before him, was no infidel. He believed in a powerful, unknowable God even as he harbored a deep skepticism about the inspiration of the Bible, the divinity of Jesus, and the intentions of religious leaders. But for most antebellum Americans, those deistical convictions placed Lincoln squarely in the infidel camp along with other doubters, agnostics, and downright atheists. Bad company for an aspiring politician, warned a friend—the same one who convinced him not to publish that “little book on Infidelity.” It was prudent advice: even without such an albatross in print, political opponents would hurl the charge of unbelief against Lincoln in his subsequent campaigns for the state legislature and Congress.1 An older and more politic Lincoln stopped ridiculing Christianity in public, and the events of his last years may also have leavened his skepticism. It appears that Lincoln came to regard the Bible as a repository of wisdom rather than as a book of fables and that the remote deist God of his youth had been supplanted by one that intervened directly in human history. His Second Inaugural, which Frederick Douglass described as “more like a sermon than a state paper,” refers to God 14 times and describes slavery as a sin for which
他们一致认为,他是个大胆的家伙。一个该死的大胆异教徒,老汤姆·潘恩。当然,并不是所有人都会走他的路,冒着他的风险,推理出他激进的自然神论。但他们中至少有一个人做到了。年轻的亚伯拉罕·林肯(Abraham Lincoln)会附和潘恩(Paine),与聚集在伊利诺伊州边境新塞勒姆百货公司(New Salem’s general store)的一群人交往——也许是为了给人留下深刻印象。他会指出《圣经》中的矛盾之处,并嘲笑那些缺乏信仰的段落。他甚至仿照潘恩的《理性时代》写了一本“关于不忠的小书”,在书中,他驳斥了童贞出生、基督的奇迹和他的复活。至于神职人员,他和潘恩一样鄙视:一群诡计多端的人,一心想通过恐吓轻信的信徒来获得金钱和权力。新萨勒姆的人用强硬的言辞点了点头,但他们不得不怀疑:那个该死的大胆异教徒林肯会后悔扇他的牙龈吗?严格地说,19世纪30年代的林肯和他之前的潘恩一样,不是异教徒。他相信一个强大的、不可知的上帝,尽管他对《圣经》的灵感、耶稣的神性和宗教领袖的意图怀有深深的怀疑。但对于大多数南北战争前的美国人来说,这些神教信仰将林肯与其他怀疑论者、不可知论者和彻头彻尾的无神论者一起完全置于异教徒阵营。一位朋友警告说,对于一位有抱负的政治家来说,这是一个糟糕的伙伴,正是这位朋友说服他不要出版那本“关于不忠的小书”,在随后的州议会和国会竞选中,政治对手会对林肯提出不信任的指控。1一个更年长、更政治的林肯不再在公共场合嘲笑基督教,他晚年发生的事件也可能加剧了他的怀疑。林肯似乎开始将《圣经》视为智慧的宝库,而不是寓言的书籍,他年轻时那个遥远的神只已经被一个直接干预人类历史的神所取代。弗雷德里克·道格拉斯(Frederick Douglass)将他的第二次就职演说描述为“更像是一次布道,而不是一份国家文件”,他14次提到上帝,并将奴隶制描述为一种罪恶
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引用次数: 0
Black Women and the Power of Biography 黑人女性和传记的力量
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0007
Alison M. Parker
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引用次数: 0
On Which Rock?: Churches, Empires, and the American Revolution 在哪个岩石上?:教会、帝国和美国革命
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0002
Adam Jortner
Was the American Revolution an old-time religious revival? Did the urge for political independence and individual rights begin with the yearning to find salvation in Christ? For a number of Americans, these questions are settled matters of fact: yes. Some of those folks have entered the public sphere with a definitive notion that because the Revolution was Christian, the United States is also Christian. Ryan Williams at the far-right Claremont Institute declared in 2021 that “The Founders were pretty unanimous, with Washington leading the way, that the Constitution is really only fit for a Christian people.”1 Williams has threatened civil war if his visions are not enacted. During the siege of the Capitol on January 6, the QAnon Shaman found his way to the Senate chamber and rededicated it to Jesus Christ. Do I have your attention? Good, because the issue of religion and the American Revolution has become one of the most critical historical questions of our own age. Much of the narrative that pervades sentiment like Williams’s derives in part from shoddy or antiquated scholarship; John Fea has shown, for example, that the popular tale of George Washington praying on his knees in the snows at Valley Forge is a myth. David Barton’s popular Christian history of Jefferson has been pulled from most bookstores because of its falsifications; it continues to sell online.2 In part, these interpretations hang on because many of the Founders were churchgoing men—Congress really did call for a day of fasting and prayer in 1775—and in part they linger because American historiography has a hard time interpreting religion except as a handmaid to politics. The current scholarly consensus assumes that religion and the Revolution were somehow
美国革命是旧时代的宗教复兴吗?对政治独立和个人权利的渴望是否始于对基督救赎的渴望?对许多美国人来说,这些问题已成定局:是的。其中一些人带着一种明确的观念进入公共领域,因为革命是基督教的,美国也是基督教的。极右翼克莱蒙特研究所(Claremont Institute)的瑞安·威廉姆斯(Ryan Williams)在2021年宣布,“在华盛顿的领导下,国父们非常一致地认为,宪法实际上只适合基督徒。”威廉姆斯威胁说,如果他的设想没有实现,就会爆发内战。在1月6日国会大厦被围困期间,卡农萨满找到了参议院会议厅,并将其重新奉献给耶稣基督。你们注意了吗?很好,因为宗教和美国革命的问题已经成为我们这个时代最关键的历史问题之一。像威廉姆斯这种充满感情的叙述,在一定程度上来自劣质或过时的学术;例如,约翰·菲亚已经证明,乔治·华盛顿在福吉谷的雪地里跪着祈祷的流行故事是一个神话。大卫·巴顿(David Barton)所著的广受欢迎的基督教杰佛逊历史,因其篡改而被大多数书店下架;它继续在网上销售一方面,这些解释之所以流传下来,是因为许多开国元勋都是去教堂的人——国会在1775年确实呼吁过斋戒和祈祷日——另一方面,这些解释之所以流传下来,是因为美国史学很难解释宗教,除非它是政治的仆人。目前的学术共识认为宗教和大革命在某种程度上是
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引用次数: 0
Impairing Public Understanding: Flawed History, Uncritical Reviews and Interviews, and Misrepresenting A-Bomb-Related History 损害公众理解:有缺陷的历史,不加批判的评论和采访,以及歪曲与原子弹有关的历史
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0009
B. Bernstein
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引用次数: 0
All (Sexual) Things in Moderation—And in Private 所有(性)事情都要适度——而且要私下进行
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0012
Natalia Mehlman Petrzela
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引用次数: 0
He Has "Travelled Much in Concord" 他“在康科德游历了很多地方”
IF 0.1 4区 历史学 Q2 HISTORY Pub Date : 2022-03-01 DOI: 10.1353/rah.2022.0004
Philip F. Gura
When Robert Gross’s The Transcendentalists and Their World arrived in my mailbox, I recalled a haunting passage in Herman Melville’s Moby-Dick. Late in the novel, Captain Ahab reminisces to first mate Starbuck how long it has been since he struck his first whale, when he was eighteen. “Forty—forty— forty years ago! Forty years of continual whaling! Forty years of privation, and peril, and storm-time!” “For forty years,” he continued, “has Ahab forsaken the peaceful land, for forty years to make war on the horrors of the deep!” But to what end? “How the better or richer is Ahab, now?”1 Those who have followed Robert Gross’s career will understand why this searing passage came to mind, for scholars now have in hand the book that they have anticipated for over forty years, ever since Gross decided to continue his deep excavation of the town of Concord, Massachusetts that he began in his Bancroft Prize-winning The Minute Men and Their World (1976). Coming when it did, his elegant history followed a handful of seminal demographic investigations of communities or discrete regions by such then-budding historians as Michael Zuckerman, Philip Greven, and Kenneth A. Lockridge.2 Armed with bulky first-generation computers, they and other demographers meticulously combed local archives for town and church records, tax lists, genealogical data, probate records, and other materials that they regarded not as historical detritus but as significant, virtually unstudied repositories for the study of family and community in the colonies. Another reason that this book has been so long in coming is because over these decades, Gross has also been engaged in other scholarship, perhaps most significantly as a member of the editorial board of, and as an editor of and contributor to, one of the volumes in the American Antiquarian Society’s five-volume History of the Book in America.3 He also is a frequent participant in various symposia whose proceedings often eventuate in publication: vide his essay on Shays’s Rebellion in the volume he edited, In Debt to Shays (1993); and another, in Transient and Permanent: The Transcendentalist Movement and its Context (1999), his contribution to a conference at the Massachusetts Historical
当罗伯特·格罗斯的《先验主义者和他们的世界》寄到我的邮箱时,我想起了赫尔曼·梅尔维尔的《白鲸》中令人难忘的一段。在小说的后半段,亚哈船长对大副斯达巴克回忆起他十八岁那年打到第一条鲸是多么久远的事。“四百四十——四十年前!”连续捕鲸四十年了!四十年的贫困、危险和风暴!"四十年来,"他继续说,"亚哈已经离开这片宁静的土地,去同深海的恐怖作战了! "但目的何在?"现在亚哈是怎样的好,怎样的富有呢?那些关注罗伯特·格罗斯事业的人会明白为什么这段令人激动的段落会出现在脑海中,因为自从格罗斯决定继续他对马萨诸塞州康科德镇的深入挖掘以来,学者们现在已经拿到了这本他们期待了四十多年的书,他在班克罗夫特奖获奖作品《一分钟的人和他们的世界》(1976)中开始了他的深入挖掘。当它到来的时候,他那优雅的历史是在当时崭露头角的历史学家迈克尔·祖克曼、菲利普·格林和肯尼斯·a·洛克里奇对社区或离散地区进行的一些开创性的人口调查之后完成的。他们和其他人口统计学家带着笨重的第一代计算机,一丝不差地梳理当地的城镇和教堂记录、纳税清单、家谱数据、遗嘱记录和其他他们认为不是历史碎片但很重要的材料。这几乎是研究殖民地家庭和社区的未经研究的资料库。这本书姗姗来迟的另一个原因是,在过去的几十年里,格罗斯也参与了其他的学术研究,最重要的可能是他是美国古物协会五卷本《美国图书史》的编辑委员会成员,也是其中一卷的编辑和撰稿人。3他还经常参加各种研讨会,这些研讨会的会议结果往往最终出版。将他关于谢斯反叛的文章收录在他编辑的《谢斯之债》(1993)一书中;另一本是《短暂和永久:先验主义运动及其背景》(1999),这是他在马萨诸塞州历史学会的一次会议上的贡献
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引用次数: 0
Discerning Seizure-Onset v. Propagation Zone: Pre-and-Post-Operative Resting-State fMRI Directionality and Boerwinkle Neuroplasticity Index. 辨别癫痫发作与传播区:手术前后静息状态 fMRI 方向性和 Boerwinkle 神经可塑性指数。
IF 3.4 4区 历史学 Q2 HISTORY Pub Date : 2022-01-01 Epub Date: 2022-05-28 DOI: 10.1016/j.nicl.2022.103063
Varina L Boerwinkle, Bethany L Sussman, Sarah N Wyckoff, Iliana Manjón, Justin M Fine, P David Adelson

The goal of this study was to determine resting state fMRI (rs-fMRI) effective connectivity (RSEC) capacity, agnostic of epileptogenic events, in distinguishing seizure onset zones (SOZ) from propagation zones (pZ). Consecutive patients (2.1-18.2 years old), with epilepsy and hypothalamic hamartoma, pre-operative rs-fMRI-directed surgery, post-operative imaging, and Engel class I outcomes were collected. Cross-spectral dynamic causal modelling (DCM) was used to estimate RSEC between the ablated rs-fMRI-SOZ to its region of highest connectivity outside the HH, defined as the propagation zone (pZ). Pre-operatively, RSEC from the SOZ and PZ was expected to be positive (excitatory), and pZ to SOZ negative (inhibitory), and post-operatively to be either diminished or non-existent. Sensitivity, accuracy, positive predictive value were determined for node-to-node connections. A Parametric Empirical Bayes (PEB) group analysis on pre-operative data was performed to identify group effects and effects of Engel class outcome and age. Pre-operative RSEC strength was also evaluated for correlation with percent seizure frequency improvement, sex, and region of interest size. Of the SOZ's RSEC, only 3.6% had no connection of significance to the pZ when patient models were individually reduced. Among remaining, 96% were in expected (excitatory signal found from SOZ → pZ and inhibitory signal found from pZ → SOZ) versus 3.6% reversed polarities. Both pre-operative polarity signals were equivalently as expected, with one false signal direction out of 26 each (3.7% total). Sensitivity of 95%, specificity 73%, accuracy of 88%, negative predictive value 88%, and positive predictive value of 88% in identifying and differentiating the SOZ and pZ. Groupwise PEB analysis confirmed SOZ → pZ EC was excitatory, and pZ → SOZ EC was inhibitory. Patients with better outcomes (Engel Ia vs. Ib) showed stronger inhibitory signal (pZ → SOZ). Age was negatively associated with absolute RSEC bidirectionally but had no relationship with Directionality SOZ identification performance. In an additional hierarchical PEB analysis identifying changes from pre-to-post surgery, SOZ → pZ modulation became less excitatory and pZ → SOZ modulation became less inhibitory. This study demonstrates the accuracy of Directionality to identify the origin of excitatory and inhibitory signal between the surgically confirmed SOZ and the region of hypothesized propagation zone in children with DRE due to a HH. Thus, this method validation study in a homogenous DRE population may have potential in narrowing the SOZ-candidates for epileptogenicity in other DRE populations and utility in other neurological disorders.

本研究旨在确定静息态 fMRI(rs-fMRI)有效连接(RSEC)能力,该能力与致痫事件无关,可用于区分癫痫发作区(SOZ)和传播区(pZ)。收集了癫痫和下丘脑火腿肠瘤连续患者(2.1-18.2 岁)的术前 rs-fMRI 引导手术、术后成像和恩格尔 I 级结果。交叉光谱动态因果建模(DCM)用于估算被消融的rs-fMRI-SOZ与其HH外最高连接区域(定义为传播区(pZ))之间的RSEC。术前,SOZ 和 PZ 之间的 RSEC 预计为正值(兴奋性),pZ 到 SOZ 之间的 RSEC 预计为负值(抑制性),术后则会减弱或消失。确定了节点间连接的敏感性、准确性和阳性预测值。对术前数据进行了参数经验贝叶斯(PEB)分组分析,以确定分组效应以及恩格尔分类结果和年龄的影响。还评估了术前 RSEC 强度与癫痫发作频率改善百分比、性别和感兴趣区大小的相关性。在 SOZ 的 RSEC 中,只有 3.6% 在患者模型单独缩小后与 pZ 没有显著联系。在剩余的RSEC中,96%是预期的(从SOZ→pZ发现兴奋信号,从pZ→SOZ发现抑制信号),而3.6%是相反的极性。术前的两个极性信号与预期的相同,在 26 个信号方向中各有一个错误信号(共占 3.7%)。在识别和区分 SOZ 和 pZ 方面,灵敏度为 95%,特异度为 73%,准确度为 88%,阴性预测值为 88%,阳性预测值为 88%。分组 PEB 分析证实 SOZ → pZ EC 为兴奋性,pZ → SOZ EC 为抑制性。预后较好的患者(Engel Ia 与 Ib)显示出较强的抑制信号(pZ → SOZ)。年龄与 RSEC 双向绝对值呈负相关,但与方向性 SOZ 识别性能无关。另一项分层 PEB 分析确定了手术前后的变化,SOZ → pZ 调制的兴奋性降低,pZ → SOZ 调制的抑制性降低。这项研究表明,在因 HH 引起的 DRE 患儿中,方向性可准确识别手术确认的 SOZ 与假定传播区之间的兴奋和抑制信号来源。因此,这项在同质 DRE 患者中进行的方法验证研究有可能缩小其他 DRE 患者中 SOZ 致痫候选区的范围,并在其他神经系统疾病中发挥作用。
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