IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-29 DOI: 10.1016/j.talanta.2026.129485

Zhengyang Shi , Hanbin Wu , Zhengxin Chen , Yao Wang , Long Zhang , Zhongxi Huang , Zhipeng Zhang , Haiyun Yin , Yusheng Xie , Changmin Yu

Real-time monitoring of hypochlorite (ClO⁻) fluctuations in inflamed tissues is crucial for evaluating the onset, progression, and prognosis of inflammatory diseases such as rheumatoid arthritis (RA). In this study, we rationally developed a small-molecule fluorescent probe (SX-ClO) based on a malononitrile–isophorone fluorophore skeleton coupled with a diaminomaleonitrile moiety as the ClO⁻-responsive unit. The probe operated through an intramolecular ICT modulation mechanism upon specific reaction with ClO⁻, enabling a remarkable fluorescence turn-on response with high selectivity, excellent sensitivity, and minimal background interference. SX-ClO demonstrated a reliable ability to visualize both endogenous and exogenous ClO⁻ in live RAW 264.7 macrophages, thereby facilitating dynamic evaluation of intracellular oxidative microenvironments. Beyond in vitro performance, SX-ClO achieved high-contrast fluorescence imaging of ClO⁻ accumulation in λ-carrageenan–induced RA mouse joints, effectively distinguishing inflamed joints from healthy ones. Moreover, the probe successfully detected elevated ClO⁻ levels in MRSA-infected wound tissues, providing clear visualization of bacterial infection–associated oxidative bursts. Overall, these properties enable real-time visualization and dynamic monitoring of pathological processes at the molecular level, highlighting its potential for clinical translation in early diagnosis and disease progression tracking.

实时监测炎症组织中次氯酸盐（ClO−）的波动对于评估炎症性疾病（如类风湿关节炎（RA））的发生、进展和预后至关重要。在这项研究中，我们合理地开发了一种基于丙二腈-异佛尔酮荧光团骨架和二氨基马来腈部分作为ClO -响应单元的小分子荧光探针（SX-ClO）。该探针通过分子内ICT调制机制与ClO−特异反应，实现了高选择性、高灵敏度和最小背景干扰的显著荧光开启响应。SX-ClO在活的RAW 264.7巨噬细胞中显示了内源性和外源性ClO−的可靠能力，从而促进了细胞内氧化微环境的动态评估。除了体外性能外，SX-ClO还实现了λ-卡拉胶诱导的RA小鼠关节中ClO−积累的高对比度荧光成像，有效区分了炎症关节和健康关节。此外，探针成功检测到mrsa感染的伤口组织中升高的ClO -水平，提供了细菌感染相关氧化爆发的清晰可视化。总的来说，这些特性能够在分子水平上实时可视化和动态监测病理过程，突出了其在早期诊断和疾病进展跟踪方面的临床转化潜力。

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引用次数: 0

Stabilizing an scu-topology Zr-MOF via linker installation for enhanced gas chromatographic separation 通过连接装置稳定scu-topology Zr-MOF，增强气相色谱分离

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.talanta.2026.129469

Chu Zeng , Hong-Tao Jiang , Ming Xu, Zhi-Yuan Gu

Flexible metal–organic frameworks (MOFs) with dynamic adaptability offered exciting opportunities for advanced separation, yet their tendency to undergo void collapse severely limited their application as gas chromatography (GC) stationary phases. Here, we overcame this challenge by stabilizing the scu-topology Zr-MOF NU-903 through a linker installation strategy. By incorporating biphenyl-4,4′-dicarboxylic acid (BPDC) into the vacant coordination pockets along the c-axis, the resulting material, NU-903-BPDC, exhibited markedly enhanced stability and structural rigidity, retaining its porosity even at 250 °C. Comprehensive characterization confirmed that the original structure was preserved, while framework flexibility was effectively suppressed. Fluorescence spectroscopy further revealed restricted ligand dynamics, corroborating the rigidified framework environment. When employed as a GC stationary phase, NU-903-BPDC delivered significantly improved resolution for C₇ hydrocarbons and dichlorobenzene isomers, benefitting from stronger thermodynamic interactions and reduced band broadening. Crucially, NU-903-BPDC maintained stable separation performance after thermal treatment, in sharp contrast to the pronounced degradation observed for pristine NU-903. This work demonstrated linker installation as an effective strategy to modulate framework flexibility, opening a general pathway toward robust, high-performance MOF-based stationary phases for chromatographic separations.

具有动态适应性的柔性金属有机骨架（mof）为高级分离提供了令人兴奋的机会，但其易于发生空隙坍塌的特性严重限制了其作为气相色谱（GC）固定相的应用。在这里，我们通过连接器安装策略稳定了scu-拓扑Zr-MOF NU-903，克服了这一挑战。通过将联苯-4,4′-二羧酸（BPDC）加入到C轴空配位袋中，得到的材料NU-903-BPDC具有显著增强的稳定性和结构刚度，即使在250℃下也能保持其孔隙度。综合表征证实其保留了原有结构，同时有效抑制了框架的柔韧性。荧光光谱进一步揭示了受限制的配体动力学，证实了僵化的框架环境。当用作GC固定相时，NU-903-BPDC对C7烃和二氯苯异构体的分辨率显著提高，受益于更强的热力学相互作用和更小的能带展宽。关键是，NU-903- bpdc在热处理后保持稳定的分离性能，与原始NU-903的明显降解形成鲜明对比。这项工作表明，连接器安装是调节框架灵活性的有效策略，为色谱分离中基于mof的稳健、高性能固定相开辟了一条普遍途径。

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引用次数: 0

Eu-MOF@Ce-MOF heterostructure and molecularly imprinted polymer composite system for SARS-CoV-2 point-of-care detection Eu-MOF@Ce-MOF异质结构和分子印迹聚合物复合体系用于SARS-CoV-2点检测

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.talanta.2026.129477

Yunfei Gao , Zi-Hao Zhao , Minghao Ma , Zhiwei Liu , Xihui Mu , Bing Liu , Bin Du , Mingzhu Xia , Fengyun Wang , Zhaoyang Tong

Metal–organic frameworks (MOFs) have attracted growing interest as advanced sensing materials due to their structural tunability and functional versatility. The responsiveness of MOF-based sensors is typically governed by changes in either the metal centers or organic linkers, making it essential to engineer novel architectures that enhance sensing performance. In this work, we present a MOF-on-MOF heterostructure (Eu-MOF@Ce-MOF), composed of a europium-based framework (Eu-MOF) and a cerium-based counterpart (Ce-MOF), synthesized via a two-step hydrothermal strategy. The Eu-MOF was first prepared using 3,5-dicarboxybenzeneboronic acid (BBDC) as the linker with Eu (III) as the metal node, while Ce-MOF was synthesized using similar synthetic conditions with Ce (III). Subsequently, Ce-MOF was anchored onto the surface of Eu-MOF to form a dual-emission MOF-on-MOF heterostructure. To further expand the applicability of this hybrid material, we integrated it with molecularly imprinted polymers (MIPs) to construct the Eu-MOF@Ce-MOF@MIP composite, which serves as both a carrier matrix and an active sensing platform. This system enabled highly selective and sensitive detection of the SARS-CoV-2 spike protein (SP) via fluorescence quenching, achieving a low detection limit (LOD) of 0.012 μM. A smartphone-integrated sensing platform was developed to facilitate on-site detection of SP in complex real samples. The results demonstrated high selectivity, reproducibility, and long-term stability, with additional validation using simulated biological matrices (serum and urine) confirming the robustness of the method. This study establishes a versatile and portable sensing strategy for SARS-CoV-2 detection, with broad implications for point-of-care detection and biosensing applications.

金属有机框架（MOFs）由于其结构的可调性和功能的多功能性，作为一种先进的传感材料受到了越来越多的关注。基于mof的传感器的响应性通常由金属中心或有机连接器的变化决定，因此设计增强传感性能的新架构至关重要。在这项工作中，我们提出了一种MOF-on-MOF异质结构（Eu-MOF@Ce-MOF），由铕基框架（Eu-MOF）和铈基框架（Ce-MOF）组成，通过两步水热策略合成。首先以3,5-二羧基苯硼酸（BBDC）为连接剂，以Eu （III）为金属节点制备了Eu- mof，以Ce （III）为金属节点，采用类似的合成条件合成了Ce- mof。随后，将Ce-MOF固定在Eu-MOF表面，形成双发射MOF-on-MOF异质结构。为了进一步扩大这种混合材料的适用性，我们将其与分子印迹聚合物（MIPs）结合起来构建Eu-MOF@Ce-MOF@MIP复合材料，该复合材料既可以作为载体矩阵，也可以作为主动传感平台。该系统通过荧光猝灭对SARS-CoV-2刺突蛋白（SP）进行了高选择性和高灵敏度的检测，检测限低至0.012 μM。开发了智能手机集成传感平台，方便了复杂真实样品中SP的现场检测。结果显示出高选择性、重复性和长期稳定性，并使用模拟生物基质（血清和尿液）进行了额外验证，证实了该方法的稳健性。本研究建立了一种多功能便携式SARS-CoV-2检测传感策略，对即时检测和生物传感应用具有广泛意义。

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引用次数: 0

Photoelectrochemical aptasensor for ultrasensitive detection of MUC1 based on titanium dioxide/polypyrrole/carboxy polyethylene glycol hybrid anti-fouling interface 二氧化钛/聚吡咯/羧基聚乙二醇杂化防污界面超灵敏检测MUC1的光电感应传感器

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-27 DOI: 10.1016/j.talanta.2026.129466

Zhencui Wang, Jinbang Wang, Jun Zhang, Chunwei Yu

Achieving ultrasensitive detection of MUC1 in the early stages of breast cancer is critical for reducing mortality and improving patient prognoses. Photoelectrochemical sensing has emerged as a promising technology for the detection of MUC1, primarily due to its straightforward operation and user-friendly instrumentation. However, titanium dioxide, a commonly used photoactive material, exhibits inherent limitations, including low charge carrier mobility and challenges related to non-specific adsorption in complex biological matrices. These issues significantly undermine the sensitivity of MUC1 detection, underscoring the urgent need for improved photoactive materials and sensing methodologies. Herein, we proposed a novel PEC aptasensor engineered with titanium dioxide/polypyrrole/carboxy polyethylene glycol (TNWs/PPy/C-PEG) hybrid anti-fouling interface via facile self-assembly. The composite of titanium dioxide nanowires and polypyrrole forms a heterojunction (TNWs/PPy) that extends the electron lifetime to 38.0 ms while significantly improving light utilization, carrier mobility, and photoelectric conversion efficiency. This enhancement ultimately amplifies the photoelectric current response. Furthermore, the negatively charged C-PEG anti-fouling unit is electrostatically anchored to the positively charged TNWs/PPy electrode surface, effectively preventing the adsorption of non-specific contaminants. Ultimately, MUC1 aptamers are immobilized on the TNWs/PPy/C-PEG photoelectrode, facilitating the selective capture of MUC1. The synergistic effects of TNWs/PPy electrode, specific recognition units, and anti-fouling layer led to a marked improvement in the selectivity and sensitivity. The detection limit of this aptasensor is 0.33 pg mL⁻¹, with a linear range from 1 pg mL⁻¹ to 500 ng mL⁻¹. Furthermore, satisfactory results were obtained in the measurement of MUC1 in serum samples. The electrostatic self-assembly strategy presents a straightforward and novel approach to ensuring the stability of anti-fouling sensing interfaces. Moreover, the incorporation of heterojunction formation for signal amplification, in conjunction with the synergistic construction of anti-fouling interfaces, offers an innovative solution for the development of advanced sensing platforms and the early detection of breast cancer.

在乳腺癌早期实现MUC1的超灵敏检测对于降低死亡率和改善患者预后至关重要。光电化学传感已经成为一种很有前途的MUC1检测技术，主要是因为它的操作简单，仪器用户友好。然而，作为一种常用的光活性材料，二氧化钛表现出固有的局限性，包括低载流子迁移率和复杂生物基质中非特异性吸附的挑战。这些问题严重破坏了MUC1检测的灵敏度，强调了改进光活性材料和传感方法的迫切需要。在此，我们提出了一种新型的PEC传感器，该传感器采用二氧化钛/聚吡咯/羧基聚乙二醇（TNWs/PPy/C-PEG）混合防污界面，通过易于自组装。二氧化钛纳米线与聚吡咯的复合材料形成了异质结（TNWs/PPy），将电子寿命延长至38.0 ms，同时显著提高了光利用率、载流子迁移率和光电转换效率。这种增强最终放大了光电电流响应。此外，带负电的C-PEG防污单元通过静电固定在带正电的TNWs/PPy电极表面，有效防止非特异性污染物的吸附。最终，MUC1适配体被固定在TNWs/PPy/C-PEG光电极上，促进MUC1的选择性捕获。TNWs/PPy电极、特异识别单元和防污层的协同作用显著提高了选择性和灵敏度。该传感器的检出限为0.33 pg mL−1，线性范围为1 pg mL−1 ~ 500 ng mL−1。此外，在血清样品MUC1的测定中获得了满意的结果。静电自组装策略为确保防污传感接口的稳定性提供了一种简单而新颖的方法。此外，结合异质结形成进行信号放大，结合防污接口的协同构建，为先进传感平台的开发和乳腺癌的早期检测提供了创新的解决方案。

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引用次数: 0

Rational design of metal nanoclusters for environmental monitoring: A review 环境监测用金属纳米团簇的合理设计综述

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-29 DOI: 10.1016/j.talanta.2026.129482

Yiqiu Xu , Anyi Wang , Kedi Yu , Dadi Liu , Hui Li , Qianrou Fan , Cheng Lv , Yang He , Xinlu Wang , Yulu Li , Zhengbo Chen , Yebin Guan , Xiaoxia Mao , Yumin Leng

As a category of functional nanomaterials with ultra-small size, excellent biocompatibility, and unique molecule-like physicochemical properties, metal nanoclusters (MNCs) have exhibited broad application prospects in the field of environmental detection over the past few years. Currently, through rational design, MNCs can be precisely integrated with various targeting moieties, which achieves the customized regulation of their physicochemical properties and functions. Compared with unmodified natural MNCs, MNCs modified with multifunctional surfaces possess more prominent advantages in environmental detection, such as improved detection sensitivity, enhanced selectivity, and reduced environmental interference. In this review, the preparation methods of gold, silver, copper, platinum and other single metals and their bimetallic/doped nanoclusters are systematically described. Secondly, the latest research progress of MNCs in the field of environmental detection is reviewed and summarized, including the application of pollutant detection based on their optical, electrochemical, and other properties. Finally, the key scientific issues and technical challenges faced by MNCs in the development of environmental detection are analyzed, and prospects for their future development direction and application prospects are put forward. The study seeks to provide theoretical and technical support for facilitating the practical application of MNCs in environmental detection.

金属纳米团簇（MNCs）作为一类具有超小尺寸、优异的生物相容性和独特的类分子物理化学性质的功能纳米材料，近年来在环境检测领域显示出广阔的应用前景。目前，通过合理的设计，可以将MNCs与各种靶向基团精确集成，实现对其理化性质和功能的定制化调节。与未经修饰的天然MNCs相比，经多功能表面修饰的MNCs在环境检测方面具有更突出的优势，如提高检测灵敏度、增强选择性、减少环境干扰等。本文系统地介绍了金、银、铜、铂等单金属及其双金属掺杂纳米团簇的制备方法。其次，回顾和总结了跨国公司在环境检测领域的最新研究进展，包括基于其光学、电化学等特性的污染物检测的应用。最后，分析了跨国公司在环境检测发展中面临的关键科学问题和技术挑战，并对其未来的发展方向和应用前景提出了展望。这项研究旨在为促进跨国公司在环境检测方面的实际应用提供理论和技术支持。

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引用次数: 0

Effect of high humidity environment on the time-resolved spectrum of laser-induced air plasma 高湿环境对激光诱导空气等离子体时间分辨光谱的影响

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-28 DOI: 10.1016/j.talanta.2026.129476

Jianyong Cen, Xin Wang, Zeguang Li, Xinjie Huo, Jinjun Zhang

Humidity is an important physical parameter that affects the measurement accuracy of laser-induced breakdown spectroscopy technology. The influence of high humidity on laser-induced air plasma at a microscopic perspective has been investigated by using a high-speed camera and high time-resolved (5 ns) spectrum. The morphological changes of air plasma under high humidity conditions were investigated. The effects of humidity on the spectral line intensity, peak time, lifetime, temperature, and electron density were analyzed. The results showed a positive correlation between the length of laser-induced air plasma and humidity. As humidity increases, the peak intensity and lifetime of the ionic and atomic spectral lines of nitrogen and oxygen decrease, while those of hydrogen atoms line increases. The peak time shows a positive correlation with humidity, indicating that humidity prolongs the time to reach peak intensity across all spectral lines. Humidity exhibits similar effects on both temperature and electron density. High humidity reduces their peak values and delays the time required to reach these peaks. This research can provide valuable experimental insights for the practical application of laser-induced breakdown spectroscopy technology in high humidity environments.

湿度是影响激光诱导击穿光谱技术测量精度的重要物理参数。利用高速摄像机和高时间分辨（5ns）光谱，从微观角度研究了高湿对激光诱导空气等离子体的影响。研究了空气等离子体在高湿条件下的形态变化。分析了湿度对光谱线强度、峰时间、寿命、温度和电子密度的影响。结果表明，激光诱导空气等离子体长度与湿度呈正相关。随着湿度的增加，氮、氧离子谱线和原子谱线的峰强度和寿命减小，而氢原子谱线的峰强度和寿命增大。峰值时间与湿度呈正相关，表明湿度延长了各谱线达到峰值强度的时间。湿度对温度和电子密度都有类似的影响。高湿度降低了它们的峰值，并延迟了达到这些峰值所需的时间。该研究可为高湿环境下激光诱导击穿光谱技术的实际应用提供有价值的实验见解。

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引用次数: 0

Capillary electrophoresis in glycosaminoglycan analysis 毛细管电泳在糖胺聚糖分析中的应用

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-18 DOI: 10.1016/j.talanta.2026.129429

Rachma Dessidianti , Márkó Grabarics , Dávid Virág , Guinevere S.M. Lageveen-Kammeijer , Éva Szökő , Lilla Turiák

Glycosaminoglycans (GAGs) are structurally complex, highly acidic polysaccharides that are produced by virtually all animal cells and play essential roles in cell communication, tissue organization, and disease processes. As key components of proteoglycans and as free saccharides, GAGs are abundant on cell surfaces and in the extracellular matrix, where they interact with a wide range of proteins such as growth factors and cytokines. Their interactions with proteins are fine-tuned by extensive structural variations of the polysaccharide chains, most importantly the attachment of sulfate modifications leading to distinct sulfation patterns. The resulting extraordinary structural complexity, however, poses significant challenges to the analysis of GAGs. Capillary electrophoresis (CE) offers distinct advantages for tackling these challenges, including exceptional resolution for charged analytes, low sample requirements, and compatibility with various detection methods. In this review, we highlight recent advances in the application of CE for GAG analysis, addressing key sample preparation steps, derivatization strategies, detection methods, and various CE modes to improve resolution and sensitivity. Challenges and benefits associated with coupling CE to mass spectrometry are addressed explicitly. Selected applications across the GAG families are presented to illustrate the utility of CE in biomedical and glycomic research. Finally, the strengths and current limitations of CE for the wider GAG analysis field are evaluated, and directions for further progress and future developments are outlined.

糖胺聚糖（GAGs）是一种结构复杂的高酸性多糖，几乎所有动物细胞都能产生，在细胞通讯、组织组织和疾病过程中起着重要作用。作为蛋白聚糖和游离糖的关键成分，GAGs大量存在于细胞表面和细胞外基质中，并与多种蛋白质（如生长因子和细胞因子）相互作用。它们与蛋白质的相互作用被多糖链的广泛结构变化微调，最重要的是硫酸盐修饰的附着导致不同的硫酸化模式。然而，由此产生的异常复杂的结构对gag的分析提出了重大挑战。毛细管电泳（CE）为解决这些挑战提供了独特的优势，包括对带电分析物的特殊分辨率，低样品要求以及与各种检测方法的兼容性。在这篇综述中，我们重点介绍了CE在GAG分析中应用的最新进展，包括关键的样品制备步骤、衍生化策略、检测方法和各种CE模式，以提高分辨率和灵敏度。挑战和利益相关的耦合CE质谱明确解决。在整个GAG家族的选择应用被提出，以说明CE在生物医学和糖喜剧研究中的效用。最后，评估了CE在更广泛的GAG分析领域的优势和当前的局限性，并概述了进一步进展和未来发展的方向。

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引用次数: 0

An antifouling electrochemical biosensor based on covalent organic framework-iridium nanocomposite functionalized with designed peptide for the detection of β-Amyloid in serum 基于设计肽功能化的共价有机骨架-铱纳米复合材料的防污电化学生物传感器用于血清中β-淀粉样蛋白的检测

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-31 DOI: 10.1016/j.talanta.2026.129483

Wenqing Wang , Baoping Zhu , Shujie Cheng , Rui Han , Min Chen , Xiliang Luo

Alzheimer's disease (AD) is a neurodegenerative disorder closely associated with the aggregation of β-Amyloid (Aβ) peptides, particularly Aβ 1–42. Electrochemical biosensors hold great potential for serological Aβ 1–42 detection due to their high sensitivity and rapid response capability. However, their performances in complex matrices such as serum are compromised by biofouling and signal interference. The biosensors with functional peptide-modified interfaces, leveraging Ir–S coordination, have had improved antifouling performance and stability. Nevertheless, conventional iridium nanoparticle (IrNPs) electrodeposition often yields heterogeneous structures with poor uniformity, limiting the consistency and sensitivity of such platforms. To address this, we developed an innovative electrochemical biosensor based on a covalent organic framework (COF)-mediated interface. Using TpPa-1 COF (Tp: 1,3,5-triformylphloroglucinol; Pa: p-phenylenediamine) as a structural template, we achieved uniform and high-density loading of IrNPs (IrNPs@COF). The functional peptides were subsequently assembled via robust Ir–S coordination, creating a synergistic antifouling sensing platform. This biosensor enables ultrasensitive and selective detection of Aβ 1–42 in serum, demonstrating significant potential for reliable early diagnosis of AD.

阿尔茨海默病（AD）是一种与β-淀粉样蛋白（a β）肽聚集密切相关的神经退行性疾病，特别是a β 1-42。电化学生物传感器具有灵敏度高、反应速度快的特点，在血清学中检测Aβ 1-42具有很大的潜力。然而，它们在复杂基质（如血清）中的性能受到生物污垢和信号干扰的影响。具有功能性肽修饰界面的生物传感器，利用Ir-S配位，具有更好的防污性能和稳定性。然而，传统的铱纳米颗粒（IrNPs）电沉积通常会产生均匀性差的非均质结构，限制了这种平台的一致性和灵敏度。为了解决这个问题，我们开发了一种基于共价有机框架（COF）介导界面的创新电化学生物传感器。使用TpPa-1 COF （Tp: 1,3,5-三甲酰间苯三醇；Pa：对苯二胺）作为结构模板，我们实现了IrNPs的均匀高密度加载（IrNPs@COF）。功能肽随后通过强大的Ir-S配位组装，创建一个协同的防污传感平台。这种生物传感器能够超灵敏和选择性地检测血清中的β 1-42，显示出可靠的阿尔茨海默病早期诊断的巨大潜力。

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引用次数: 0

Studying the capabilities of graphite furnace atomic absorption spectrometry for the discrimination of ionic copper from copper and/or copper oxide nanoparticles 研究了石墨炉原子吸收光谱法从铜和/或氧化铜纳米颗粒中鉴别离子铜的能力

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-24 DOI: 10.1016/j.talanta.2026.129459

Beatriz Gómez-Nieto, Marcela Robayo-Barragán, María Jesús Gismera, María Teresa Sevilla, Jesús Rodríguez Procopio

This work explores the applicability of Graphite Furnace Atomic Absorption Spectrometry (GFAAS) for the discrimination of ionic copper (Cu²⁺) from copper and/or copper(II) oxide nanoparticles (Cu NPs and/or CuO NPs). To perform the measurements of the NPs by GFAAS, the preparation of stable suspensions from commercial solid standards of NPs with different average sizes was first evaluated. Among the evaluated dispersion media, sodium dodecyl sulphate (SDS) provided the most stable suspensions for both Cu and CuO NPs. The atomization delay (t_ad), defined as the time to reach maximum absorbance, was used as the parameter to discriminate between Cu species. Under the evaluated conditions, Cu²⁺ exhibited higher t_ad values than the nanoparticulate forms. The t_ad values remained constant for Cu concentrations ranging from 5 to 40 μg L⁻¹ for all species, demonstrating the independence of the discrimination parameter from analyte content. In addition, similar concentration calibration slopes were obtained for all species, indicating the feasibility of performing the quantification using only Cu²⁺ standards. The effects of pyrolysis and atomization temperatures, as well as the atomization heating ramp, on the resolution between the t_ad values of the Cu species were evaluated. The best time resolution for the discrimination was obtained using a pyrolysis temperature of 350 °C, a very slow atomization heating rate of 100 °C s⁻¹ and an atomization temperature of 2300 °C. Finally, the analysis of Cu²⁺ and Cu NP mixtures revealed non-additive signal profiles, suggesting possible ion - NP interactions that modify the species distribution during atomization.

这项工作探讨了石墨炉原子吸收光谱法（GFAAS）在铜和/或铜（II）氧化物纳米粒子（Cu NPs和/或CuO NPs）中离子铜（Cu2+）的适用性。为了用GFAAS法对NPs进行测量，首先对不同平均粒径的NPs商用固体标准制备的稳定悬浮液进行了评估。在评价的分散介质中，十二烷基硫酸钠（SDS）对Cu和CuO NPs的悬浮液最稳定。将雾化延迟（tad）定义为达到最大吸光度的时间，作为区分铜种的参数。在评价条件下，Cu2+的tad值高于纳米颗粒形式。在Cu浓度为5 ~ 40 μg L−1的范围内，所有物种的tad值保持不变，表明该判别参数与分析物含量无关。此外，所有物种均获得了相似的浓度校准斜率，表明仅使用Cu2+标准进行定量的可行性。考察了热解温度、雾化温度以及雾化升温梯度对Cu组分之间析出度的影响。在热解温度为350℃，雾化加热速率为100℃s−1，雾化温度为2300℃的条件下，获得了最佳的分辨时间。最后，对Cu2+和Cu NP混合物的分析显示了非加性信号谱，表明离子- NP相互作用可能改变了原子化过程中的物种分布。

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引用次数: 0

μ-LIBS imaging of archaeological ceramics: Quantification of clay fraction in provenance study 考古陶瓷的μ-LIBS成像：黏土组分在物源研究中的定量

IF 6.1 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2026-06-01 Epub Date: 2026-01-23 DOI: 10.1016/j.talanta.2026.129452

Nicolas Herreyre , Valérie Thirion-Merle , Loan Lemaître , Anne Schmitt , Christine Oberlin , Clothilde Comby-Zerbino , Vincent Motto-Ros

The provenance and circulation of archaeological ceramics are key to understanding ancient societies' trade networks and cultural exchanges. However, comparing coarse and fine wares using bulk compositional analysis remains challenging due to the variable chemical contribution of temper (e.g., sand), which masks the signature of the raw clay. This study introduces a novel quantitative μ-LIBS (micro-Laser-Induced Breakdown Spectroscopy) imaging methodology to isolate and analyse the clay fraction composition of archaeological ceramics, enabling direct geochemical comparisons between tempered coarse wares and fine wares for provenance studies.

By combining multi-elemental mapping (Ca, Fe, Ti, K, Si, Al, Mg, Mn, Na, P, Zr, Rb, Sr, Ba) with calibration based on bulk X-ray fluorescence spectrometry, the method provides accurate microscale quantification. Elemental maps are segmented to extract the clay fraction composition, overcoming the limitations of traditional bulk analysis. The protocol was validated using fired briquettes with controlled sand contents and firing temperatures, confirming its accuracy and robustness.

Applied to four coarse ware specimens (mainly amphorae) from Lugdunum (Roman Lyon (France) during the Augustan-period, the reconstructed clay compositions were compared to a reference database of 235 contemporaneous ceramics, including coarse wares and three Lugdunum Terra sigillata production groups. Results reveal a shared raw clay source between calcareous amphorae and La Muette B sigillata, supporting earlier hypotheses, while other sigillata wares remain compositionally distinct. This approach significantly advances ceramic provenance studies, particularly for complex assemblages, by enabling direct comparisons between ware types previously hindered by temper variability, together with the common total bulk elemental composition measurements.

考古陶瓷的来源和流通是了解古代社会贸易网络和文化交流的关键。然而，由于回火（如沙子）的化学贡献变化，使用散装成分分析来比较粗陶器和细陶器仍然具有挑战性，这掩盖了原始粘土的特征。本研究引入了一种新的定量μ-LIBS（微激光诱导击穿光谱）成像方法，用于分离和分析考古陶瓷的粘土组分组成，从而可以直接对回火粗陶器和精细陶器进行地球化学比较，用于物源研究。通过结合多元素映射（Ca, Fe, Ti， K, Si, Al, Mg, Mn, Na， P, Zr, Rb, Sr, Ba）和基于体x射线荧光光谱的校准，该方法提供了精确的微尺度定量。元素图分割提取粘土组分组成，克服了传统体分析的局限性。该方案通过控制砂含量和烧成温度的燃烧型煤进行验证，证实了其准确性和稳健性。应用于4个奥古斯都时期Lugdunum （Roman Lyon (France)）的粗糙陶器标本（主要是双耳陶器），重建的粘土成分与235个同时期陶瓷的参考数据库进行了比较，包括粗糙陶器和三个Lugdunum Terra sigillata生产群。结果显示，钙质双耳陶罐和La Muette B sigillata具有共同的原始粘土来源，支持了之前的假设，而其他sigillata陶器在成分上仍然不同。这种方法通过直接比较以前受温度变化影响的陶瓷类型，以及常见的总体元素组成测量，显著地推进了陶瓷来源研究，特别是复杂组合。

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