Talanta最新文献_第7页

A sensing strategy based on novel pyrene-functionalized MOFs for sVCAM-1 detection and prognostic assessment in coronary heart disease

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128184

Mei Ma , Guangxin Liu , Fuju Dai , Xiangrui Wang , Deyu Qin , Mengai Yin , Lina Lu , Zhijie Wang , Tong Wang , Zibo Wang , Xinmeng Liu , Qiang Chen , Jun Jiao

Coronary heart disease (CHD) remains a significant global health concern, with exercise therapy playing a crucial role in rehabilitation. Optimizing exercise intensity is essential, as both insufficient and excessive exercise may lead to suboptimal or adverse outcomes. In response to this challenge, we developed Adaptive Posture-Balance Cardiac Rehabilitation Exercise (APBCRE), which integrates postural balance training with aerobic exercise. To evaluate its therapeutic efficacy, we designed a novel fluorescent biosensor targeting soluble vascular cell adhesion molecule-1 (sVCAM-1), a key biomarker of endothelial inflammation. The biosensor utilizes pyrene-functionalized metal–organic framework (PCA-UiO-66), synthesized via a one-pot approach. Within the MOF, pyrenecarboxylic acid (PCA) exists primarily in the excimer state, exhibiting stable fluorescence emission, a narrow spectral peak, and a wide Stokes shift. For the purpose of identify sVCAM-1, the sVCAM-1-specific aptamer was functionalized to PCA-UiO-66. When sVCAM-1 is present, the aptamer is competitively stripped from the MOF surface by the target. This process induces π–π stacking interactions between the aptamer's phosphate backbone and PCA molecules, facilitating PCA release and transition from the excimer to the monomer state. By quantifying the fluorescence value of monomer state PCA, the fluorescence response allowed precise quantification of sVCAM-1, with a detection limit of 0.69 ng/mL and a range of 2 ng/mL to 50 μg/mL. We analyzed cardiopulmonary performance and serum sVCAM-1 levels in 20 CHD patients who underwent APBCRE. These findings establish APBCRE as an effective rehabilitation strategy that provides both physiological and molecular benefits while also confirming Apt@PCA-UiO-66 as a robust biosensing tool for monitoring therapeutic efficacy and elucidating CHD pathophysiology.

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引用次数: 0

LoC-SERS detection platform based on targeted signal anchoring mechanism, high-sensitivity detection of protein biomarkers in precancerous lesions of gastric cancer

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128190

Yanwen Zhuang , Feng Lu , Xiaoyong Wang , Jie Yao , Yong Wan , Shichen Qin , Xiaowei Cao , Jinxin Sheng

In this study, a novel lab-on-a-chip surface-enhanced Raman scattering (LoC-SERS) analysis platform was developed based on chip laboratory for monitoring precancerous lesions of GC. The platform integrated graphene-like Au nano-hexagonal arrays (Au NHAs) as a high-efficiency plasma substrate with the highly integrated microarray chip as an ideal system for sensitive recognition and rapid quantification of matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) based on the targeted signal anchoring mechanism. Au NHAs were surface modified to form a double stranded structure with aptamer chains and single stranded DNA1 (ssDNA1), Au nanobipyramid with Ag shell (Au NBP@Ag) surface modified single stranded DNA2 (ssDNA2) and Raman signaling molecules. When the target is present, the aptamer specifically captures the target protein and detaches from the Au NHAs surface, exposing ssDNA1 and ssDNA2 to pair and bind. This resulted in the Au NBP@Ag probe carrying the signaling molecule anchoring to the surface of Au NHAs, thereby enhancing the SERS signal. The platform demonstrated excellent detection efficiency and could complete detection tasks within 20 min. The platform can detect MMP-9 and IL-6 at levels down to the pg/mL order of magnitude, demonstrating excellent detection sensitivity. In addition, the platform has the capability of simultaneous dual-target detection, demonstrating good clinical applicability and accuracy when testing real serum samples. Overall, this platform provides an efficient solution for early diagnosis and progression monitoring of precancerous lesions of GC, further providing a scientific basis for clinical decision-making and intervention.

本研究开发了一种基于芯片实验室的新型片上实验室表面增强拉曼散射（LoC-SERS）分析平台，用于监测 GC 癌前病变。该平台集成了石墨烯类金纳米六方阵列（Au NHAs）作为高效等离子体基底，以及高度集成的微阵列芯片，是基于靶向信号锚定机制灵敏识别和快速定量基质金属蛋白酶-9（MMP-9）和白细胞介素-6（IL-6）的理想系统。Au NHA经表面修饰后与aptamer链和单股DNA1（ssDNA1）形成双链结构，Au纳米双锥体与Ag外壳（Au NBP@Ag）表面修饰的单股DNA2（ssDNA2）和拉曼信号分子形成双链结构。当目标出现时，适配体会特异性地捕获目标蛋白质，并从金 NBP@Ag 表面脱离，从而使 ssDNA1 和 ssDNA2 配对并结合。这使得携带信号分子的 Au NBP@Ag 探针锚定在 Au NHAs 表面，从而增强了 SERS 信号。该平台表现出卓越的检测效率，可在 20 分钟内完成检测任务。该平台可以检测到低至皮克/毫升数量级的 MMP-9 和 IL-6，表现出极佳的检测灵敏度。此外，该平台还能同时进行双目标检测，在检测真实血清样本时具有良好的临床适用性和准确性。总之，该平台为 GC 癌前病变的早期诊断和进展监测提供了有效的解决方案，进一步为临床决策和干预提供了科学依据。

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引用次数: 0

Rapid and portable detection of hepatocellular carcinoma marker alpha-fetoprotein using a droplet evaporation-based biosensor

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128189

Ying Jia , Hui Zhao , Shitang Huang , Fangchao Yin , Weiwei Wang , Qiongzheng Hu , Yunshan Wang , Bin Feng

The rapid and accurate detection of tumour markers in human serum is essential for the early screening and diagnosis of cancer. In this study, we develop a droplet evaporation-based biosensor for the detection of the tumour marker alpha-fetoprotein (AFP). The biosensor's mechanism relies on the evaporation of surfactant solutions containing varying concentrations of AFP on a hydrophobic plastic substrate, resulting in distinct dried droplet patterns with varying areas. Surfactant solutions containing myristoylcholine (Myr) produce large dried droplet patterns due to surface wetting. Upon the introduction of AFP, a complex is formed on magnetic beads (MBs) comprising AFP aptamer 1 (apt1), AFP, and a dual-functional single-stranded DNA that includes AFP aptamer 2 (apt2) and the acetylcholinesterase (AChE) aptamer. This interaction immobilizes AChE on the MBs through its specific binding to its aptamer. Notably, AChE hydrolyses Myr, leading to a reduction in the dried droplet pattern area, enabling AFP detection. This biosensor demonstrates high selectivity, stability, and repeatability for AFP, with a low detection limit of 1.27 ng/mL and a reliable linear detection range of 5–25 ng/mL. Additionally, it performs effectively in human serum sample tests. This approach offers a rapid, portable, and efficient method for AFP detection and holds significant potential for clinical applications in the early screening and diagnosis of cancer.

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引用次数: 0

Synthesis of multi-template imprinted mesoporous silica nanoparticles via micelle-based interface imprinting strategy for specific and efficient extraction of five cinnamic acid derivatives from traditional Chinese medicines 通过基于胶束的界面印迹策略合成多模板印迹介孔二氧化硅纳米颗粒，用于特异高效提取中药中的五种肉桂酸衍生物

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128180

Rongrong Xing , Tingyu Xue , Huangjin Li , Yifei Zhou , Xuan Chen , Shuang Hu

Cinnamic acid derivatives, a crucial group of active components in traditional Chinese medicines (TCMs), encompass chlorogenic acid, caffeic acid, 4-hydroxycinnamic acid, ferulic acid, and cinnamic acid. These compounds exhibit a wide array of pharmacological activities, such as free radical scavenging, antioxidation, antibacterial effects, and antitumor activity. However, traditional separation and detection methods often suffer from poor selectivity, low extraction efficiencies, and insufficient sensitivity, thus limiting their applicability in studying the complex and diverse active component groups in TCMs. Herein, we proposed a novel micelle-based interface imprinting strategy by integrating multi-template imprinting with mesoporous silica. Specifically, caffeic acid, serving as an epitope template for chlorogenic acid, along with 4-hydroxycinnamic acid, ferulic acid, and cinnamic acid, collectively constituted a multi-template system. Micelles were generated using a cationic surfactant cetyltrimethylammonium bromide, which confined the four template molecules to the micelle surface through electrostatic attraction. Aminopropyltriethoxysilane, 3-ureidopropyltriethoxysilane, and benzyltriethoxysilane were selected as functional monomers, while tetraethyl orthosilicate were selected as both a cross-linker and a silicon source for the synthesis of multi-template imprinted mesoporous silica nanoparticles (MTIMSNs). The MTIMSNs demonstrated high specificity and impressive adsorption capacity for chlorogenic acid, caffeic acid, 4-hydroxycinnamic acid, ferulic acid, and cinnamic acid, with maximum cross-reactivities of 8.8 %, 7.6 %, 6.8 %, 9.5 %, and 11.5 %, respectively, and corresponding adsorption capacities of 3.712, 4.114, 4.843, 3.517, and 2.814 mg/g, respectively. The MTIMSNs-based affinity extraction coupled with high performance liquid chromatography have been successfully applied to the determination of the five cinnamic acid derivatives in Taraxaci Herba.

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引用次数: 0

Sensitive analysis of polyamines by micellar-electrokinetic chromatography with laser-induced fluorescence (MEKC-LIF) in mineral media samples

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128172

Ilona Olędzka , Dominika Dmochowska , Michał Pieckowski , Krzysztof Waleron , Małgorzata Waleron , Tomasz Bączek , Piotr Kowalski

A micellar electrokinetic chromatography (MEKC) method coupled with laser-induced fluorescence (LIF) detection was developed and validated for the determination of five aliphatic polyamines in mineral media samples. Since polyamines lack inherent UV chromophores or fluorophores, fluorescence detection was enhanced using precapillary derivatization with fluorescein isothiocyanate isomer I (FITC). Key parameters affecting the derivatization, including reagent concentration, reaction time, and temperature, were optimized to improve sensitivity. Under optimal conditions, with a background electrolyte (BGE) of 20 mM borax and 20 mM SDS, polyamines were successfully separated, achieving limits of detection as low as 0.03 μM for cadaverine and 0.09 μM for putrescine, spermine, spermidine, and norspermidine. The method demonstrated the importance of borate complexation and the use of anionic surfactants for improving both sweeping and fluorescence signal intensity. The MEKC-LIF method was applied to analyze polyamines in mineral media from in vitro cultures of Arabidopsis thaliana and Pectobacterium betavasculorum, grown individually and in co-culture. Results showed that bacteria can synthesize or degrade polyamines, suggesting their importance in plant-bacteria interactions. The method enables sensitive analysis of polyamine metabolism, and its use provides insights into inter-kingdom communication.

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引用次数: 0

Electrochemical genomagnetic assay for detection of SARS-CoV-2 RNA using a disposable microfluidic platform

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128186

Daniel Júnior Almeida dos Santos , Tássia Regina de Oliveira , Henrique Pott-Junior , Matias Eliseo Melendez , Ester Cerdeira Sabino , Ronaldo Censi Faria

Background

The COVID-19 pandemic exposed the world to one of the greatest challenges in our history, causing profound social and economic impacts. With the advance of the pandemic, it became evident that there was a need for new diagnostic tests for monitoring and controlling the disease. In this sense, we describe the development of a genomagnetic assay based on the use of a fully disposable electrochemical microfluidic device for detection of RNA from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in saliva samples.

Results

A simple and low-cost disposable microfluidic platform (DμP) containing unmodified carbon-based electrodes was developed and coupled to a 3D holder containing neodymium magnets for detection of SARS-CoV-2 RNA in saliva samples. The device allows up to 8 simultaneous detections using the genomemagnetic assay, providing sensitivity with a limit of detection of 0.44 fmol L⁻¹ and a limit of quantification of 1.44 fmol L⁻¹, with a linear range of 5.0 fmol L⁻¹ to 200.0 nmol L⁻¹. The proposed assay has been successfully applied for the diagnosis of COVID-19 in cohorts of positive and negative individuals, showing excellent agreement with the results obtained by reverse transcription-polymerase chain reaction (RT-PCR). The genomagnectic assay showed the ability to discriminate between healthy individuals and patients infected with SARS-CoV-2, showing 82.4 % and 100.0 % of clinical sensitivity and specificity, respectively.

Significance

The method developed allows a simple, low-cost, and quantitative detection of viral RNA requiring no transcription or DNA amplification steps showing excellent reproducibility. The genomagnetic assay proposed can be an alternative tool for the diagnosis and monitoring of COVID-19 and even could be easily adapted for detection of other single-stranded RNA viruses.

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引用次数: 0

Diverse pore-sized sulfonic acid covalent organic frameworks for solid-phase extraction of fluoroquinolones in food samples

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128142

Shi-qi Ao , Shuang-Ping Liu , Yun Jiang , Xiu-Ping Yan , Hai-Long Qian

Tuning the pore size of covalent organic frameworks (COFs) to achieve maximum adsorption performance is an effective way for promoting the enrichment of trace fluoroquinolones (FQs) in food, but it remains challenging. Herein, we prepare three pore-sized sulfonic acid functionalized COFs (SF-COFs), named TPS, TBS, and TSS, to investigate the effect of pore size on the adsorption efficiency of FQs. These three SF-COFs exhibit excellent adsorption capacities for FQs including enrofloxacin (ENR), norfloxacin (NOR), and ciprofloxacin (CIP). Notably, TBS achieves a maximum adsorption capacity of 627.3 mg g⁻¹ for NOR, resulting from its suitable pore size (1.6 times larger than the size of FQs). Accordingly, we further develop a novel TBS based solid-phase extraction to couple with high-performance liquid chromatography for determination of FQs in various foods, which achieves rapid extraction (10 min), low detection limits (0.007–0.01 ng mL⁻¹), wide linear range (0.1–1000 ng mL⁻¹), and good recoveries (83.7%–105.2%).

{"title":"Diverse pore-sized sulfonic acid covalent organic frameworks for solid-phase extraction of fluoroquinolones in food samples","authors":"Shi-qi Ao , Shuang-Ping Liu , Yun Jiang , Xiu-Ping Yan , Hai-Long Qian","doi":"10.1016/j.talanta.2025.128142","DOIUrl":"10.1016/j.talanta.2025.128142","url":null,"abstract":"<div><div>Tuning the pore size of covalent organic frameworks (COFs) to achieve maximum adsorption performance is an effective way for promoting the enrichment of trace fluoroquinolones (FQs) in food, but it remains challenging. Herein, we prepare three pore-sized sulfonic acid functionalized COFs (SF-COFs), named TPS, TBS, and TSS, to investigate the effect of pore size on the adsorption efficiency of FQs. These three SF-COFs exhibit excellent adsorption capacities for FQs including enrofloxacin (ENR), norfloxacin (NOR), and ciprofloxacin (CIP). Notably, TBS achieves a maximum adsorption capacity of 627.3 mg g<sup>−1</sup> for NOR, resulting from its suitable pore size (1.6 times larger than the size of FQs). Accordingly, we further develop a novel TBS based solid-phase extraction to couple with high-performance liquid chromatography for determination of FQs in various foods, which achieves rapid extraction (10 min), low detection limits (0.007–0.01 ng mL<sup>−1</sup>), wide linear range (0.1–1000 ng mL<sup>−1</sup>), and good recoveries (83.7%–105.2%).</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"294 ","pages":"Article 128142"},"PeriodicalIF":5.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rapid and specific fluorescent probe based on ESIPT-AIE-active for copper ion quantitative detection in food and environmental samples

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128188

Xiaomei Ren , Ji Liu , Yating Zhang , Jianing Zhang , Yuanlan Yang , Wenjian Yang , Jianhui Liu , Anxiang Su , Hui Xu , Zhenwei Yuan

In the field of food safety, the identification and measurement of active components in food is a pressing issue. The concentration of copper ions (Cu²⁺) in the environment is closely linked to food safety, and overall biological health. Therefore, developing rapid and accurate analytical techniques to monitor Cu²⁺ in food is of great significance. In this study, two fluorescent probes L-2 and L-3 were synthesized through a simple Schiff base condensation reaction. And L-3 demonstrated better anti-interference ability to Cu²⁺ than that of L-2. Meanwhile, spectroscopic experiments showed that L-3 possessed an extremely low detection limit (LOD) and low limits of quantification (LOQ) (LOD = 92.79 nM, LOQ = 309.33 nM), and quickly respond time (<30 s). Probe L-3 for monitoring effectively quantitatively identified Cu²⁺ in food and environmental samples, achieving an accuracy rate ranging from 84.42% to 117.45% and precision with a relative standard deviation (RSD) of less than 6.0%. The accuracy had been validated using the inductively coupled plasma-mass spectrometry (ICP-MS). Simultaneously, a WeChat Mini Program has been developed to detect total copper content in food samples based on fluorescence values, enabling consumers to evaluate food safety more intuitively. Moreover, L-3 also facilitated the quantitative visualization of Cu²⁺ in biological systems, underscoring its compatibility and practicality.

{"title":"A rapid and specific fluorescent probe based on ESIPT-AIE-active for copper ion quantitative detection in food and environmental samples","authors":"Xiaomei Ren , Ji Liu , Yating Zhang , Jianing Zhang , Yuanlan Yang , Wenjian Yang , Jianhui Liu , Anxiang Su , Hui Xu , Zhenwei Yuan","doi":"10.1016/j.talanta.2025.128188","DOIUrl":"10.1016/j.talanta.2025.128188","url":null,"abstract":"<div><div>In the field of food safety, the identification and measurement of active components in food is a pressing issue. The concentration of copper ions (Cu<sup>2+</sup>) in the environment is closely linked to food safety, and overall biological health. Therefore, developing rapid and accurate analytical techniques to monitor Cu<sup>2+</sup> in food is of great significance. In this study, two fluorescent probes L-2 and L-3 were synthesized through a simple Schiff base condensation reaction. And L-3 demonstrated better anti-interference ability to Cu<sup>2+</sup> than that of L-2. Meanwhile, spectroscopic experiments showed that L-3 possessed an extremely low detection limit (LOD) and low limits of quantification (LOQ) (LOD = 92.79 nM, LOQ = 309.33 nM), and quickly respond time (<30 s). Probe L-3 for monitoring effectively quantitatively identified Cu<sup>2+</sup> in food and environmental samples, achieving an accuracy rate ranging from 84.42% to 117.45% and precision with a relative standard deviation (RSD) of less than 6.0%. The accuracy had been validated using the inductively coupled plasma-mass spectrometry (ICP-MS). Simultaneously, a WeChat Mini Program has been developed to detect total copper content in food samples based on fluorescence values, enabling consumers to evaluate food safety more intuitively. Moreover, L-3 also facilitated the quantitative visualization of Cu<sup>2+</sup> in biological systems, underscoring its compatibility and practicality.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"294 ","pages":"Article 128188"},"PeriodicalIF":5.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an indirect competitive enzyme immunoassay for detection of a plant elicitor methiadinil

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-18 DOI: 10.1016/j.talanta.2025.128149

Yue Zhang , Rongyan Shen , Yuting Huang , Zhihong Wang , Liangfu Tang , Zhijin Fan

Plant elicitors with distinctive benefits including low toxicity, small application dosages and an innovative mode of action are considered as green agrochemicals by stimulating the host plant immunity. Several new plant elicitors have been developed for tobacco protection against virus attack. Among them, as a milestone in Chinese plant elicitor development, methiadinil (IUPAC: 4-methyl-N-(5-methylthiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide) shows broad application prospects. Because of its low application dosage, its residue determination requires diverse highly sensitive method. Here we developed an indirect enzyme-linked immunosorbent assay (ELISA) method for methiadinil residue determination with the lowest detection limit of 10.69 ng/mL and a linear detection range between 21.84 ng/mL of IC₂₀ and 1513.81 ng/mL of IC₈₀ by a rational hapten designation. Meanwhile, this indirect ELISA method showed good specificity with low cross-reactivity for methiadinil analogue determination and a good correlation with the HPLC method for tobacco sample measurement. This sensitive, rapid and accurate methiadinil residue determination method in tobacco leaves is of great significance for the monitoring of methiadinil in tobacco and guidance for other environmental sample determination and the rational application of methiadinil.

{"title":"Development of an indirect competitive enzyme immunoassay for detection of a plant elicitor methiadinil","authors":"Yue Zhang , Rongyan Shen , Yuting Huang , Zhihong Wang , Liangfu Tang , Zhijin Fan","doi":"10.1016/j.talanta.2025.128149","DOIUrl":"10.1016/j.talanta.2025.128149","url":null,"abstract":"<div><div>Plant elicitors with distinctive benefits including low toxicity, small application dosages and an innovative mode of action are considered as green agrochemicals by stimulating the host plant immunity. Several new plant elicitors have been developed for tobacco protection against virus attack. Among them, as a milestone in Chinese plant elicitor development, methiadinil (IUPAC: 4-methyl-<em>N</em>-(5-methylthiazol-2-yl)-1,2,3-thiadiazole-5-carboxamide) shows broad application prospects. Because of its low application dosage, its residue determination requires diverse highly sensitive method. Here we developed an indirect enzyme-linked immunosorbent assay (ELISA) method for methiadinil residue determination with the lowest detection limit of 10.69 ng/mL and a linear detection range between 21.84 ng/mL of IC<sub>20</sub> and 1513.81 ng/mL of IC<sub>80</sub> by a rational hapten designation. Meanwhile, this indirect ELISA method showed good specificity with low cross-reactivity for methiadinil analogue determination and a good correlation with the HPLC method for tobacco sample measurement. This sensitive, rapid and accurate methiadinil residue determination method in tobacco leaves is of great significance for the monitoring of methiadinil in tobacco and guidance for other environmental sample determination and the rational application of methiadinil.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"294 ","pages":"Article 128149"},"PeriodicalIF":5.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable arginine sensing on polyvinyl alcohol membrane based on aggregation-induced emission enhancement of carbon dots

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta

Pub Date : 2025-04-17 DOI: 10.1016/j.talanta.2025.128177

Dou Yang , Tong Shao , Peng Li , Xiaoshuang Wang , Suyuan Zeng , Min Hong , Rui Li , Qiaoli Yue

Carbon dots (CDs) were highly promised nanomaterials for application in food analysis, owing to their exceptional optical properties, superior photostability, and negligible biological toxicity. N-doped CDs (NCDs) were synthesized via a straightforward hydrothermal method utilizing folic acid as only one precursor material. NCDs exhibited deep blue fluorescence under an ultraviolet lamp with a quantum yield (QY) of 14.54 %. In the presence of arginine (Arg), there was a noticeable redshift of 10 nm in the maximum emission wavelength of NCDs, accompanied by fluorescence transition from dark blue to bright blue. The QY of NCDs was 16.71 % in the presence of Arg. In other words, NCDs showed aggregation-induced emission enhancement (AIEE) in the presence of Arg. The fluorescence enhancement exhibited a strong linear correlation with Arg concentration within the range of 0–300 μM, and the limit of detection was 0.31 μM. Furthermore, to facilitate Arg detection, a portable Arg sensor was developed using a polyvinyl alcohol membrane-assisted design. The sensor demonstrated satisfactory performance in detecting Arg in real samples. These findings highlighted the versatile capabilities of NCDs with AIEE properties, paving the way for their potential applications in food analysis.

{"title":"Portable arginine sensing on polyvinyl alcohol membrane based on aggregation-induced emission enhancement of carbon dots","authors":"Dou Yang , Tong Shao , Peng Li , Xiaoshuang Wang , Suyuan Zeng , Min Hong , Rui Li , Qiaoli Yue","doi":"10.1016/j.talanta.2025.128177","DOIUrl":"10.1016/j.talanta.2025.128177","url":null,"abstract":"<div><div>Carbon dots (CDs) were highly promised nanomaterials for application in food analysis, owing to their exceptional optical properties, superior photostability, and negligible biological toxicity. N-doped CDs (NCDs) were synthesized via a straightforward hydrothermal method utilizing folic acid as only one precursor material. NCDs exhibited deep blue fluorescence under an ultraviolet lamp with a quantum yield (QY) of 14.54 %. In the presence of arginine (Arg), there was a noticeable redshift of 10 nm in the maximum emission wavelength of NCDs, accompanied by fluorescence transition from dark blue to bright blue. The QY of NCDs was 16.71 % in the presence of Arg. In other words, NCDs showed aggregation-induced emission enhancement (AIEE) in the presence of Arg. The fluorescence enhancement exhibited a strong linear correlation with Arg concentration within the range of 0–300 μM, and the limit of detection was 0.31 μM. Furthermore, to facilitate Arg detection, a portable Arg sensor was developed using a polyvinyl alcohol membrane-assisted design. The sensor demonstrated satisfactory performance in detecting Arg in real samples. These findings highlighted the versatile capabilities of NCDs with AIEE properties, paving the way for their potential applications in food analysis.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"294 ","pages":"Article 128177"},"PeriodicalIF":5.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0