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A review on advancing sustainable vegan meat alternatives through scalable production of plant-based smart proteins 通过大规模生产植物性智能蛋白质来推进可持续纯素肉类替代品的综述
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-11 DOI: 10.1016/j.tifs.2025.105497
Shubhi Singh, Meena Krishania

Background

Meeting the global demand for protein has become a critical challenge, as animal meat production imposes significant environmental and health burdens. Plant-based smart proteins (PBSP) have emerged as a potential source to produce vegan meat due to improved nutritional quality, diverse functional properties and compatibility with modern structuring techniques. Moreover, the valorization of agricultural residues, abundant in countries like India, provides a renewable feedstock for PBSP while simultaneously reducing waste and pollution.

Scope and approach

This review provides insights into recent advances in PBSP research, highlighting their functional properties, extraction methods and formulation strategies to replicate meat-like texture, flavor and juiciness through extrusion, shear cell processing, freeze structuring and 3D printing techniques. Furthermore, it also examines flavor masking and fat simulation approaches to overcome sensory limitations, alongside life cycle assessment examples that determine industrial viability of PBSP.

Key findings and conclusion

PBSP exhibit essential techno-functional traits, such as gelation, water- and oil-holding capacities as well as emulsifying potential, which are critical for replicating fibrous and anisotropic structures in vegan meat. Moreover, PBSP offer environmental benefits, including reduced land use, water consumption, and greenhouse gas emissions compared to conventional meat production. However, the functional performance can vary depending on the protein extraction and processing methods employed, particularly when derived from agri-residues. Therefore, by integrating smart proteins with agri-residue valorization and advanced structuring techniques, this review outlines a roadmap for the scalable, cost-effective and environmentally sustainable production of vegan meat analogues, bridging scientific innovation with industrial application.
满足全球对蛋白质的需求已成为一项重大挑战,因为动物肉类生产给环境和健康带来了沉重负担。基于植物的智能蛋白(PBSP)由于其改善的营养质量、多样化的功能特性以及与现代结构技术的兼容性,已成为生产纯素肉的潜在来源。此外,在印度等国家,大量的农业残留物的增值为PBSP提供了可再生原料,同时减少了浪费和污染。本文综述了PBSP的最新研究进展,重点介绍了PBSP的功能特性、提取方法和配方策略,通过挤压、剪切细胞加工、冷冻结构和3D打印技术来复制肉的质地、风味和多汁性。此外,它还研究了风味掩蔽和脂肪模拟方法,以克服感官限制,以及确定PBSP工业可行性的生命周期评估示例。pbsp具有基本的技术功能特征,如凝胶、持水和持油能力以及乳化潜力,这对于复制素食肉类中的纤维和各向异性结构至关重要。此外,与传统肉类生产相比,PBSP具有环境效益,包括减少土地使用、水消耗和温室气体排放。然而,功能性能可能因所采用的蛋白质提取和加工方法而异,特别是当从农业残留物中提取时。因此,通过将智能蛋白质与农业残留物增值和先进的结构技术相结合,本文概述了可扩展,成本效益和环境可持续的纯素肉类类似物生产的路线图,将科学创新与工业应用联系起来。
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引用次数: 0
Anthocyanin-based indicator labels for intelligent food packaging: Mechanisms, multiscale regulation, and future perspectives for enhancing color-response performance 智能食品包装中基于花青素的指示标签:机制,多尺度调节,以及提高颜色响应性能的未来前景
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-11 DOI: 10.1016/j.tifs.2025.105495
Yiwen Bao , Huijun Cui , Xu Si , Jiaxin Li , Tao Huang , Bin Li

Background

As global food safety risks and food waste issues become increasingly severe, intelligent indicator labels have garnered attention as an emerging non-destructive visual monitoring method. Anthocyanin-based indicator labels demonstrate unique potential in food freshness monitoring due to their highly specific color-response to environmental pH fluctuations and volatile compounds. However, their coloration behavior remains constrained by the challenge of balancing stability and sensitivity.

Scope and approach

This paper systematically reviews the color response mechanisms of anthocyanin indicator labels in food freshness monitoring, incorporating the “Stimulus-Transport-Reaction-Colorimetry (S-T-R-C)” framework as a novel organizing principle, and critically examines recent research advances in multiscale color-response regulation strategies. It focuses on four key aspects: pH initialization, intermolecular copigmentation, nano/micro-scale confined release, and porosity regulation. Additionally, the paper discusses the prospects and key challenges of anthocyanin indicator labels in practical food packaging.

Key findings and conclusions

This review reveals that the color-response of anthocyanin indicator labels is fundamentally a strongly microenvironment-driven multiscale coupled process, with their color development behavior jointly determined by the synergistic effects of stimulation, mass transport, and structural transformation. By introducing the S-T-R-C framework, we systematically organize the color development mechanism of anthocyanin indicator labels and elucidate the complementary roles of regulatory strategies in balancing stability and sensitivity. However, anthocyanin indicator labels still face challenges in signal stability, colorimetric standardization, customized regulation, multidimensional response, structural controllability, and overall safety and sustainability. Future efforts should integrate diverse strategies to optimize performance and accelerate the transition of anthocyanin indicator labels from laboratory research to industrialization.
随着全球食品安全风险和食物浪费问题的日益严重,智能指示牌作为一种新兴的无损视觉监控手段受到了人们的关注。基于花青素的指示剂标签在食品新鲜度监测中表现出独特的潜力,因为它们对环境pH值波动和挥发性化合物具有高度特异性的颜色响应。然而,它们的着色行为仍然受到平衡稳定性和灵敏度的挑战的限制。本文以“刺激-转运-反应-比色法(S-T-R-C)”为新的组织原理,系统地综述了食品新鲜度监测中花青素指示剂标签的颜色反应机制,并对多尺度颜色反应调节策略的最新研究进展进行了批判性的回顾。它侧重于四个关键方面:pH初始化,分子间共色素沉着,纳米/微尺度限制释放和孔隙调节。此外,本文还讨论了花青素指示标签在实际食品包装中的应用前景和面临的主要挑战。花青素指示剂标签的显色反应本质上是一个微环境驱动的多尺度耦合过程,其显色行为是由刺激、质量传递和结构转化的协同作用共同决定的。通过引入S-T-R-C框架,系统梳理花青素指示剂标签的显色机制,阐明调控策略在平衡稳定性和敏感性中的互补作用。然而,花青素指标标签在信号稳定性、比色标准化、定制化调控、多维响应、结构可控、整体安全性和可持续性等方面仍面临挑战。未来的努力应整合多种策略,以优化性能,加快花青素指标标签从实验室研究到工业化的过渡。
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引用次数: 0
Sustainable bioactive peptides from by-products of woody oil plants: Updated insights into biological functions and molecular modelling 木本油料植物副产品的可持续生物活性肽:生物功能和分子模型的最新见解
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-11 DOI: 10.1016/j.tifs.2025.105498
Thanh Ninh Le , Haiying Cai , Yaxuan Shang , Phu Hung Nguyen , Xuezhi Fang , Yu Cao , Zisheng Luo , Jing Wang , Fengqin Feng , Minjie Zhao

Background

By-products of woody oil plants (BWOPs), such as pressed cakes and defatted meals generated during oil extraction, are protein-rich resources with great potential for high-value applications. Valorizing these proteins into bioactive peptides (BPs) can enhance economic value, reduce waste, and promote the development of functional foods and nutraceuticals, thus contributing to a more sustainable woody oil industry.

Scope and approach

The review aims to provide an updated overview of BPs derived from BWOPs (BWOPPs), covering their biological activities and mechanisms of action. Notably, it highlights advanced bioinformatics approaches to enable the investigation of BWOPPs.

Key findings and conclusions

BWOPPs hold considerable potential as ingredients for functional foods and nutraceuticals, exhibiting various bioactivities, such as antioxidant, anti-inflammatory, antihypertensive, antidiabetic, antihyperlipidemic, and neuroprotective effects. Recent advances in peptide characterization, including molecular modeling techniques such as quantitative structure-activity relationships, virtual screening, molecular docking, molecular dynamics simulations, and quantum chemistry calculations, combined with experimental validation in cell and animal models, strongly support their further development and application.
木本油料植物的副产品,如榨油过程中产生的压榨饼和脱脂粕,是富含蛋白质的资源,具有巨大的高价值应用潜力。将这些蛋白质转化为生物活性肽(bp)可以提高经济价值,减少浪费,促进功能食品和保健品的开发,从而促进木本油工业的可持续发展。本综述旨在提供BWOPPs (BWOPPs)衍生的bp的最新概述,包括其生物活性和作用机制。值得注意的是,它强调了先进的生物信息学方法,使BWOPPs的调查成为可能。sbwopps具有抗氧化、抗炎、降压、降糖尿病、降血脂和神经保护等多种生物活性,在功能食品和营养保健品中具有相当大的潜力。肽表征的最新进展,包括定量构效关系、虚拟筛选、分子对接、分子动力学模拟和量子化学计算等分子建模技术,以及细胞和动物模型的实验验证,有力地支持了它们的进一步发展和应用。
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引用次数: 0
Dynamic flavor mapping to breast milk in infant formula: From volatile biomarkers to synthetic biology-driven flavor optimization 婴儿配方奶粉中母乳的动态风味映射:从挥发性生物标志物到合成生物学驱动的风味优化
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-11 DOI: 10.1016/j.tifs.2025.105482
Mengyuan Yang , Jianfeng Wang , Yufang Su, Baoguo Sun, Nasi Ai

Background

Breast milk contains a rich array of volatile compounds, whose unique flavor profile is crucial for infant acceptance and early taste development. However, existing infant formula (IF) products suffer from flavor limitations due to processing methods, raw material constraints, and flavor defects (e.g., bitterness from hydrolysed proteins and lipid oxidation off-flavors), which can impair infant feeding and healthy development.

Scope and approach

This study systematically reviews the key flavor differences between breast milk and IF, along with potential biomarkers. It then reviews bitterness masking and flavor simulation technologies for IF.

Key findings and conclusions

Finally, we identifies clinical application requirements and commercialization challenges for IF, and proposes future cross-development directions for IF, such as synthetic biology and sensoryomics-driven formulation design. This review not only provides actionable strategies to resolve persistent sensory defects in commercial infant nutrition, but also establishes a robust framework for interdisciplinary innovation, bridging food chemistry, sensory science, and bioengineering, to advance next-generation formula tailored for infant acceptance and metabolic health.
母乳含有丰富的挥发性化合物,其独特的风味对婴儿的接受和早期味觉发育至关重要。然而,现有的婴儿配方奶粉(IF)产品由于加工方法、原料限制和风味缺陷(如水解蛋白质和脂质氧化产生的苦味)而受到风味限制,这可能会影响婴儿的喂养和健康发育。本研究系统地回顾了母乳和IF之间的主要风味差异,以及潜在的生物标志物。然后回顾了中频的苦味掩蔽和风味模拟技术。最后,我们确定了IF的临床应用需求和商业化挑战,并提出了IF未来的交叉发展方向,如合成生物学和感觉组学驱动的配方设计。这篇综述不仅为解决商业婴儿营养中持续存在的感官缺陷提供了可行的策略,而且还建立了跨学科创新的强大框架,将食品化学、感官科学和生物工程联系起来,以推进适合婴儿接受和代谢健康的下一代配方。
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引用次数: 0
Common bean in a changing world: biogeography, nutrition, and microbiome innovations for future food security 变化世界中的普通豆:面向未来粮食安全的生物地理学、营养学和微生物组创新
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-11 DOI: 10.1016/j.tifs.2025.105496
Shrabana Sarkar , Cynthia Meza , Basilio Carrasco , Mabel Delgado , Patrick Okoth , Aparna Banerjee

Background

Common bean (Phaseolus vulgaris L.) is a nutritionally valuable crop worldwide, contributing significantly to food security. It is rich in protein, dietary fiber, essential minerals, vitamins, and antioxidant compounds with health-promoting properties. Domesticated ∼8000 years ago in north–south corridor from modern-day Mexico to the Andes, it gave rise to two major gene pools, Andean and Mesoamerican, along with minor gene pool Peru/Ecuador, each gave rise to distinct ecological races. Following domestication, its global spread enabled broad adaptability and large-scale production. Globally, production is concentrated in Asia, Americas, and Africa.

Scope and approach

Despite its relevance, common bean cultivation faces several threats due to rising temperatures, altered rainfall patterns, and prolonged droughts, reducing yield and nutritional quality. To address these challenges, this review integrates three traditionally disconnected research domains (i) biogeography and gene-pool diversity, (ii) nutritional and functional food value, and (iii) microbiome specially PGPB innovations, into a unified framework. By synthesizing genetic, physiological, ecological, and microbiome-based evidence, we outline how plant growth promoting bacteria (PGPB) such as Rhizobium, Azospirillum sp., Bacillus spp., Pseudomonas spp, Cupriavidus sp., Ralstonia sp., Burkholderia spp., Paraburkholderia sp., can be strategically combined with genetic traits to enhance nutrient acquisition, stress resilience, nitrogen fixation, and tolerance to drought, salinity, and pathogens to secure sustainable yields.

Key findings and conclusions

This review provides the first integrated cross-disciplinary roadmap linking common bean biogeography, nutritional potential, and plant–microbe interactions to guide climate-smart breeding and sustainable production. We highlight how leveraging gene-pool–specific traits alongside next-generation microbial inoculants may boost productivity, reduce environmental impact, and ensure future food security.
菜豆(Phaseolus vulgaris L.)是世界范围内具有重要营养价值的作物,对保障粮食安全具有重要意义。它富含蛋白质、膳食纤维、必需矿物质、维生素和具有促进健康特性的抗氧化化合物。大约8000年前,在从现代墨西哥到安第斯山脉的南北走廊上,它被驯化,产生了两个主要的基因库,安第斯和中美洲基因库,以及秘鲁/厄瓜多尔的小基因库,每个基因库都产生了不同的生态种族。在驯化之后,它的全球传播使其具有广泛的适应性和大规模生产。在全球范围内,生产集中在亚洲、美洲和非洲。尽管普通豆种植具有相关性,但由于气温上升、降雨模式改变和长期干旱,导致产量和营养质量下降,普通豆种植面临着若干威胁。为了应对这些挑战,本文将三个传统上互不相关的研究领域(i)生物地理学和基因库多样性,(ii)营养和功能性食品价值,以及(iii)微生物组,特别是PGPB创新,整合到一个统一的框架中。通过综合遗传、生理、生态和微生物学方面的证据,我们概述了植物生长促进细菌(PGPB)如根瘤菌、偶氮螺旋菌、芽孢杆菌、假单胞菌、铜杆菌、拉尔斯顿菌、伯克霍尔德菌、副伯克霍尔德菌等如何与遗传性状有策略地结合,以提高养分获取、逆境恢复能力、固氮能力以及对干旱、盐和病原体的耐受性,以确保可持续产量。本综述提供了首个将普通豆生物地理、营养潜力和植物-微生物相互作用联系起来的综合跨学科路线图,以指导气候智慧型育种和可持续生产。我们强调如何利用基因库特异性性状与下一代微生物接种剂可以提高生产力,减少对环境的影响,并确保未来的粮食安全。
{"title":"Common bean in a changing world: biogeography, nutrition, and microbiome innovations for future food security","authors":"Shrabana Sarkar ,&nbsp;Cynthia Meza ,&nbsp;Basilio Carrasco ,&nbsp;Mabel Delgado ,&nbsp;Patrick Okoth ,&nbsp;Aparna Banerjee","doi":"10.1016/j.tifs.2025.105496","DOIUrl":"10.1016/j.tifs.2025.105496","url":null,"abstract":"<div><h3>Background</h3><div>Common bean (<em>Phaseolus vulgaris</em> L.) is a nutritionally valuable crop worldwide, contributing significantly to food security. It is rich in protein, dietary fiber, essential minerals, vitamins, and antioxidant compounds with health-promoting properties. Domesticated ∼8000 years ago in north–south corridor from modern-day Mexico to the Andes, it gave rise to two major gene pools, Andean and Mesoamerican, along with minor gene pool Peru/Ecuador, each gave rise to distinct ecological races. Following domestication, its global spread enabled broad adaptability and large-scale production. Globally, production is concentrated in Asia, Americas, and Africa.</div></div><div><h3>Scope and approach</h3><div>Despite its relevance, common bean cultivation faces several threats due to rising temperatures, altered rainfall patterns, and prolonged droughts, reducing yield and nutritional quality. To address these challenges, this review integrates three traditionally disconnected research domains (i) biogeography and gene-pool diversity, (ii) nutritional and functional food value, and (iii) microbiome specially PGPB innovations, into a unified framework. By synthesizing genetic, physiological, ecological, and microbiome-based evidence, we outline how plant growth promoting bacteria (PGPB) such as <em>Rhizobium</em>, <em>Azospirillum</em> sp., <em>Bacillus</em> spp., <em>Pseudomonas</em> spp, <em>Cupriavidus</em> sp., <em>Ralstonia</em> sp., <em>Burkholderia</em> spp., <em>Paraburkholderia</em> sp., can be strategically combined with genetic traits to enhance nutrient acquisition, stress resilience, nitrogen fixation, and tolerance to drought, salinity, and pathogens to secure sustainable yields.</div></div><div><h3>Key findings and conclusions</h3><div>This review provides the first integrated cross-disciplinary roadmap linking common bean biogeography, nutritional potential, and plant–microbe interactions to guide climate-smart breeding and sustainable production. We highlight how leveraging gene-pool–specific traits alongside next-generation microbial inoculants may boost productivity, reduce environmental impact, and ensure future food security.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"168 ","pages":"Article 105496"},"PeriodicalIF":15.4,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural deviations between native and precision fermentation-derived food proteins: Techno-functionality and structure formation strategies 天然和精密发酵食品蛋白之间的结构偏差:技术功能和结构形成策略
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-10 DOI: 10.1016/j.tifs.2025.105493
J.K. Keppler , M.W.T. Werten , R.M. Boom
Precision fermentation enables the production of animal-like proteins without the need for livestock. However, transforming these recombinant proteins into functional food ingredients remains challenging, as their molecular properties often differ from animal-derived counterparts. Furthermore, complete food products also require the integration of fat and carbohydrates. The review focusses on the structural differences commonly found in recombinant dairy, egg proteins and gelatin compared to their animal-derived counterparts and explores strategies to produce food analogues with these ingredients. Key differences include N-terminal extensions and differential posttranslational modifications such as glycosylation, which can significantly impact protein functionality. Proteolytic degradation in the recombinant host as well as the presence of non-target (protein) impurities can also alter the functionality. Food structuring using recombinant proteins can follow two main approaches. The bottom-up approach assembles individual proteins into aggregates with specific properties, such as casein micelles. This approach is strongly dependent on the molecular properties of the proteins, which can be modulated by structural deviations through the choice of the host and the genetic polymorph of the target protein. The alternative is a top-down approach, where specific process conditions are applied to a formulation that contains fat, proteins and carbohydrates in the required composition. This approach depends on macromolecular properties such as phase behavior and association of the ingredients and is therefore affected by the presence of non-protein components from the host.
Based on the listed findings, future processes can be developed that take molecular and macromolecular properties of the recombinant protein ingredient into account.
精密发酵可以在不需要牲畜的情况下生产类似动物的蛋白质。然而,将这些重组蛋白转化为功能性食品成分仍然具有挑战性,因为它们的分子特性通常与动物源性蛋白质不同。此外,完整的食品也需要脂肪和碳水化合物的整合。这篇综述的重点是在重组乳制品、鸡蛋蛋白质和明胶中常见的结构差异,与它们的动物源性对应物相比,并探讨了用这些成分生产食品类似物的策略。关键的差异包括n端延伸和不同的翻译后修饰,如糖基化,这可以显著影响蛋白质的功能。重组宿主体内的蛋白水解降解以及非目标(蛋白质)杂质的存在也会改变其功能。利用重组蛋白构建食物结构可以遵循两种主要方法。自下而上的方法将单个蛋白质组装成具有特定性质的聚集体,例如酪蛋白胶束。这种方法强烈依赖于蛋白质的分子特性,这可以通过宿主的选择和目标蛋白质的遗传多态性来调节结构偏差。另一种方法是自上而下的方法,在特定的工艺条件下应用于含有所需成分的脂肪,蛋白质和碳水化合物的配方。这种方法取决于大分子性质,如相行为和成分的关联,因此受到来自宿主的非蛋白成分的影响。基于所列出的发现,可以开发考虑重组蛋白成分的分子和大分子特性的未来工艺。
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引用次数: 0
Phage-based biosensors: From recognition to signal transduction empowered by amplification strategies for detecting foodborne pathogens 基于噬菌体的生物传感器:从识别到信号转导,通过放大策略来检测食源性病原体
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-10 DOI: 10.1016/j.tifs.2025.105492
Fan Li, Xinxin Jiang, Yizhao Zhang, Ruiting Yao, Haorui Zhu, Lihua Fan, Guoliang Li

Background

Phages exhibit unique attributes including high specificity toward target bacteria, the capability to discriminate viable from dead bacteria, and modifiability, rendering them exceptional recognition elements for constructing biosensors aimed at detecting foodborne pathogens. However, current research lacks a systematic analysis of the detection targets and markers, as well as the signal amplification strategies, in phage-based biosensors.

Scope and approach

This review summarizes recent advances in phage-based biosensors for viable bacteria detection, with a focus on detection targets and markers, signal amplification strategies, as well as the design and applications of these biosensing platforms. Firstly, it systematically categorizes the detection targets and markers used in phage-based biosensors, including bacterial surface receptors, lysate components released from host bacteria, and progeny phages. Subsequently, it details the signal amplification strategies employed, encompassing magnetic separation, optical materials, electroactive substances, and nucleic acid amplification techniques. Additionally, it systematically summarizes the working principles of phage-based biosensors and their applications in the detection of foodborne pathogens. Finally, the challenges and outlooks in this field have been discussed.

Key findings and conclusions

Owing to advantages such as specific recognition of viable bacteria, rapid response, and low cost, phage-based biosensors exhibit superior biosensing performance when combined with various signal amplification strategies. Phage-based biosensors have demonstrated remarkable point-of-care testing (POCT) potential in food safety analysis, providing an efficient tool for the detection of foodborne pathogens.
噬菌体具有独特的特性,包括对目标细菌的高特异性,区分活菌和死菌的能力以及可修饰性,使它们成为构建旨在检测食源性病原体的生物传感器的特殊识别元素。然而,目前的研究缺乏对基于噬菌体的生物传感器的检测靶点和标记物以及信号放大策略的系统分析。本文综述了近年来基于噬菌体的活菌检测生物传感器的研究进展,重点介绍了检测靶点和标记物、信号放大策略以及这些生物传感平台的设计和应用。首先,对噬菌体生物传感器的检测靶点和标记物进行了系统的分类,包括细菌表面受体、宿主细菌释放的裂解物成分和噬菌体后代。随后,详细介绍了所采用的信号放大策略,包括磁分离、光学材料、电活性物质和核酸扩增技术。此外,系统综述了基于噬菌体的生物传感器的工作原理及其在食源性致病菌检测中的应用。最后,对该领域面临的挑战和前景进行了讨论。基于噬菌体的生物传感器具有对活菌的特异性识别、快速响应和低成本等优势,与多种信号放大策略相结合,具有优异的生物传感性能。基于噬菌体的生物传感器在食品安全分析中显示出显著的即时检测(POCT)潜力,为检测食源性病原体提供了一种有效的工具。
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引用次数: 0
Physical properties as the key bridge from structure-activity relationship to AI-guided rational design of food-derived bioactive peptides: A systematic review 物理性质是从构效关系到人工智能引导的食品生物活性肽合理设计的关键桥梁:系统综述
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-09 DOI: 10.1016/j.tifs.2025.105483
Huizhen Xing, Huimin Dong, Chengzhi Guo, Zhigao Wang, Rong He

Background

The development of food-derived bioactive peptides (BAPs) is hindered by a critical translational challenge: numerous peptides with demonstrated efficacy in vitro show limited activity in vivo or face difficulties in integration into food products. This disconnect stems from a fundamental knowledge gap, specifically the absence of a systematic framework that connects peptide structure to dynamic function through their underlying physicochemical properties. This gap severely impedes the field's progression from empirical discovery towards rational design for targeted applications in functional foods and nutraceuticals.

Scope and approach

To bridge this gap, this review introduces a novel framework centered on the pivotal role of physical properties in connecting peptide structure to function and application. Its approach is twofold: first, by systematically delineating how five key properties (molecular weight, charge, conformational stability, solubility, and permeability) govern functionality, absorption, and food matrix compatibility; and second, by synthesizing progress in leveraging artificial intelligence (AI) to decode complex structure-property-function relationships, thereby paving the way for the accelerated design of optimized peptides.

Key findings and conclusions

Analysis reveals that molecular weight dictates absorption pathways and bioactive mechanisms, while charge characteristics master-regulate target interactions, solubility, and stability. Conformational stability is identified as a prerequisite for high-affinity binding, and the solubility-permeability balance emerges as the critical bottleneck for oral bioavailability. The integrated optimization of these properties, empowered by AI, is shown to enable the rational development of next-generation peptide-based ingredients with tailored functions and enhanced efficacy. This work introduces the pivotal perspective that physical properties constitute the essential nexus for understanding BAP behavior. Key challenges identified include navigating the solubility-permeability trade-off, developing AI models capable of predicting higher-order structural behavior, and achieving multi-objective optimization that simultaneously balances bioactivity, stability, and sensory attributes for successful food application.
食品来源的生物活性肽(BAPs)的开发受到一个关键的转化挑战的阻碍:许多在体外证明有效的肽在体内的活性有限,或者在与食品的整合中面临困难。这种脱节源于一个基本的知识缺口,特别是缺乏一个系统的框架,通过其潜在的物理化学性质将肽结构与动态功能联系起来。这一差距严重阻碍了该领域从经验发现到功能性食品和营养保健品目标应用的理性设计的进展。为了弥补这一空白,本文介绍了一个新的框架,该框架以物理性质在连接肽结构与功能和应用中的关键作用为中心。它的方法有两个方面:首先,通过系统地描述五个关键特性(分子量、电荷、构象稳定性、溶解度和渗透性)如何影响功能、吸收和食物基质相容性;第二,通过综合利用人工智能(AI)来解码复杂的结构-属性-功能关系的进展,从而为优化肽的加速设计铺平道路。分析表明,分子量决定了吸收途径和生物活性机制,而电荷特性则主要调节靶标相互作用、溶解度和稳定性。构象稳定性被认为是高亲和力结合的先决条件,溶解度-渗透性平衡成为口服生物利用度的关键瓶颈。通过人工智能对这些特性进行综合优化,可以合理开发具有定制功能和增强功效的下一代肽基成分。这项工作介绍了关键的观点,即物理性质构成了理解BAP行为的基本联系。确定的主要挑战包括导航溶解度-渗透性权衡,开发能够预测高阶结构行为的人工智能模型,以及实现多目标优化,同时平衡生物活性、稳定性和感官属性,以成功应用于食品。
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引用次数: 0
The emerging role of blockchain technology in ensuring food safety: A review 区块链技术在确保食品安全中的新作用:综述
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-09 DOI: 10.1016/j.tifs.2025.105489
Yujia Ruan , Pius Unachukwu , Soottawat Benjakul , Yuhao Zhang , Yu Fu

Backgrounds

The global food safety system is challenged by fragmented information flows across supply chains, with traditional traceability methods being susceptible to data tampering and update delays. Blockchain technology presents a transformative solution with its decentralized and immutable ledger system.

Scope and approach

This review systematically examines blockchain's potential and implementation pathways for enhancing food safety. It outlines the technology's fundamental principles, analyzes its multifaceted applications within food supply chains, and assesses practical deployment obstacles. Emerging trends from its integration with IoT and AI are also examined.

Key findings and conclusions

Blockchain establishes a tamper-resistant foundation for food safety management via decentralized ledgers, cryptographic hashing, consensus mechanisms, and smart contracts. These features enable end-to-end traceability and mitigate single points of failure. Integration with IoT sensors allows real-time monitoring of critical parameters and automates fraud prevention and compliance checks across diverse food sectors. Empirical evidence confirms its efficacy in reducing food fraud and improving regulatory compliance, especially in transnational and high-risk contexts. Consortium blockchains are particularly suitable for enterprise-level implementation. While challenges in scalability and interoperability persist, layered architectures and cross-chain protocols offer promising solutions. Future integration with AI and IoT is poised to bolster dynamic risk prediction and foster a more resilient food system.
全球食品安全系统受到供应链上碎片化信息流的挑战,传统的可追溯性方法容易受到数据篡改和更新延迟的影响。区块链技术以其分散和不可变的分类账系统提供了一种变革性的解决方案。范围和方法本综述系统地考察了区块链在加强食品安全方面的潜力和实施途径。它概述了该技术的基本原理,分析了其在食品供应链中的多方面应用,并评估了实际部署的障碍。还研究了其与物联网和人工智能集成的新兴趋势。区块链通过分散的分类账、加密散列、共识机制和智能合约,为食品安全管理建立了一个防篡改的基础。这些特性支持端到端可跟踪性并减少单点故障。与物联网传感器的集成可以实时监控关键参数,并自动防止欺诈和检查不同食品部门的合规性。经验证据证实了其在减少食品欺诈和改善监管合规方面的有效性,特别是在跨国和高风险背景下。联盟区块链特别适合企业级实施。虽然可伸缩性和互操作性方面的挑战仍然存在,但分层架构和跨链协议提供了有前途的解决方案。未来与人工智能和物联网的融合将加强动态风险预测,并建立一个更具弹性的粮食系统。
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引用次数: 0
Insect-based biopolymers from Orthoptera: An emerging resource for sustainable and active food packaging 直翅目昆虫基生物聚合物:可持续和活性食品包装的新兴资源
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-12-09 DOI: 10.1016/j.tifs.2025.105484
Oscar Zannou , Barbara Conti , Linda Abenaim , João K. Lopes , Paula Barciela , Custódio L. Roriz , Miguel A. Prieto , Sandrina A. Heleno , Marcio Carocho , Gulden Goksen

Background

The challenges of the current era in food packaging have led to a continuous diversification of sources of biopolymers. Edible Orthopterans have garnered significant interest worldwide as potential sources of biopolymers for the production of biodegradable and active packaging. These insect species have emerged as a potential and sustainable substitute for conventional protein and chitosan sources due to their high nutritional content and eco-friendly cultivation methods.

Scope and approach

This review explores the recent development of sustainable sources of biopolymers, focusing on the edible Orthopterans. We elucidated the main edible Orthoptera species used as the sources of biopolymers for food packaging, extraction methods of biopolymers from Orthopterans, fabrication of packaging materials and their characteristics. Moreover, we analyzed the current applications of these packaging materials for food preservation. Furthermore, we proposed a critical analysis of the health issues, consumer acceptance, legislation and commercialization, along with the future directions.

Key findings and conclusions

Acheta domesticus, Gryllodes sigillatus and Locusta migratoria are the Orthopterans used as sources of biopolymers for the production of packaging materials. Chitosan and proteins are the major Orthopteran-derived biopolymers used for the production of sustainable, edible and bioactive food packaging materials. Emerging technologies have shown potential to enhance extraction efficiency while preserving the functionality of the biopolymers. These biopolymers exhibit remarkable potential for the development of food packaging materials, due to their biodegradability, biocompatibility, and functional properties. More research initiatives and awareness are needed to facilitate the implementation of Orthopteran-derived biopolymers as active packaging materials.
当今时代对食品包装的挑战导致了生物聚合物来源的不断多样化。可食用矫形动物作为生物聚合物的潜在来源,在世界范围内引起了极大的兴趣,用于生产可生物降解和活性包装。这些昆虫因其高营养含量和环保的栽培方法而成为传统蛋白质和壳聚糖的潜在可持续替代品。范围和方法本文综述了生物聚合物可持续来源的最新发展,重点是可食用的骨科动物。本文综述了食品包装用可食用直翅目生物聚合物的主要来源、直翅目生物聚合物的提取方法、包装材料的制备及其特点。此外,我们还分析了这些包装材料在食品保鲜中的应用现状。此外,我们还提出了健康问题、消费者接受度、立法和商业化的批判性分析,以及未来的发展方向。主要发现和结论家蝇(sacheta domesticus)、灰蝗(Gryllodes sigillatus)和迁徙蝗(Locusta migratoria)是用于生产包装材料的生物聚合物的直翅目动物。壳聚糖和蛋白质是主要的骨科衍生生物聚合物,用于生产可持续、可食用和生物活性的食品包装材料。新兴技术已经显示出在保持生物聚合物功能的同时提高提取效率的潜力。这些生物聚合物由于其生物可降解性、生物相容性和功能特性,在食品包装材料的发展中表现出显著的潜力。需要更多的研究倡议和意识来促进骨科衍生生物聚合物作为活性包装材料的实施。
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引用次数: 0
期刊
Trends in Food Science & Technology
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