Trends in Food Science & Technology最新文献_第6页

Recent advances in micro/mesoporous nanocomposites for electrochemical detection of food contaminants: synthesis, physicochemical properties, and applications 用于食品污染物电化学检测的微/介孔纳米复合材料的研究进展：合成、理化性质及应用

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-11-03 DOI: 10.1016/j.tifs.2025.105418

Yingkun Shi , Yi Shen

Background

Contemporary global food safety faces increasingly severe challenges from food contaminants such as heavy metal ions, aflatoxins, pesticide residues, and antibiotics. Contaminant detection in food serves as a foundational technology for the sustainable development of the food industry. Recent breakthroughs in the applications of micro/mesoporous nanomaterials (MMNs) have significantly contributed to the development of electrochemical sensing techniques. The development of highly effective sensing platforms facilitates the on-site detection of harmful substances, thereby enhancing food safety and safeguarding human health.

Scope and approach

MMNs possess tunable pore architectures, favorable processing characteristics, and high specific surface areas. Meanwhile, the nanoconfinement effect inherent to the MMNs significantly enhances the reaction kinetics. In this review, we systematically summarized recent progress in the synthesis strategies, advantageous properties, and applications of MMNs in multimodal sensing platforms for food contaminants. Furthermore, we briefly elucidated the sensing mechanisms of different MMN-based sensors and their specific applications for detecting key food contaminants.

Key findings and conclusions

This review summarized the advantages and competitive capabilities of MMNs in electrochemical sensing applications. Substantial evidence indicated that integrating MMNs into electrochemical sensor development holds great prospect for advancing food contaminant detection. Consequently, MMNs leveraging with tunnable pore strucutres and nanoconfinement effects, represent essential components for constructing robust sensing platforms with high stability and specificity through interfacial engineering. Furthermore, this paper provided a critical examination of the current challenges and future development prospects of MMN-based sensors. Future research should explore MMN-based sensing integration with emerging technologies such as artificial intelligence and quantum computing.

当代全球食品安全面临着重金属离子、黄曲霉毒素、农药残留、抗生素等食品污染物日益严峻的挑战。食品污染物检测是食品工业可持续发展的基础技术。近年来，微/介孔纳米材料（MMNs）在应用上的突破极大地促进了电化学传感技术的发展。高效传感平台的发展有利于有害物质的现场检测，从而提高食品安全，保障人类健康。mmns具有可调节的孔隙结构、良好的加工特性和高比表面积。同时，MMNs固有的纳米约束效应显著提高了反应动力学。本文系统综述了近年来MMNs的合成策略、优势特性及其在食品污染物多模态传感平台中的应用进展。此外，我们简要阐述了不同基于mmn的传感器的传感机制及其在检测关键食品污染物方面的具体应用。本文综述了MMNs在电化学传感应用中的优势和竞争能力。大量证据表明，将MMNs集成到电化学传感器开发中，对于推进食品污染物检测具有广阔的前景。因此，利用可隧道孔结构和纳米约束效应的MMNs是通过界面工程构建具有高稳定性和特异性的鲁棒传感平台的重要组成部分。此外，本文还对基于mmn的传感器的当前挑战和未来发展前景进行了批判性的研究。未来的研究应该探索基于mmn的传感与人工智能和量子计算等新兴技术的集成。

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引用次数: 0

Plant-derived bioactive peptides in anti-aging applications: From molecular mechanisms to advanced delivery platforms 植物源性生物活性肽在抗衰老中的应用：从分子机制到先进的递送平台

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-11-03 DOI: 10.1016/j.tifs.2025.105419

Xiyu Qin , Wentao Xu , Lili Qiu , Yixuan Li , Rong Liu , Longjiao Zhu , Xiaoyu Wang

Background

Plant-derived bioactive peptides (PBPs) exhibit multi-target anti-aging potential, with high safety, structural diversity, and sustainable sourcing. However, their rapid gastrointestinal degradation, poor bioavailability, and limited tissue specificity remain major barriers to clinical translation and functional food development.

Scope and approach

This review systematically integrates recent advances in the anti-aging effects of PBPs and focuses on elucidating their molecular mechanisms through key signaling pathways such as PI3K/Akt/mTOR, AMPK/SIRT1/PGC-1α, and NF-κB. It also evaluates advanced delivery strategies, including nanoparticles, liposomes, hydrogels, micelles, and emulsions, and their roles in enhancing stability, bioavailability, and targeting efficiency via various administration routes such as oral, transdermal, nasal, and injectable. Special attention is given to emerging technologies such as stimuli-responsive materials, three-dimensional printing, and artificial intelligence-assisted design, highlighting their promising applications in next-generation precision delivery platforms.

Key findings and conclusions

PBPs mediate anti-aging effects by synergistically modulating antioxidant defense, immune balance, mitochondrial homeostasis, apoptosis, autophagy, and stem cell activity. Despite advances in delivery technologies enhancing pharmacokinetics and pharmacodynamics, personalized, large-scale, and tissue-specific delivery remains challenging. The combination of intelligent materials, multimodal fabrication, and AI-driven prediction offers promising avenues for the effective translation of PBPs into functional foods and therapeutic agents for healthy aging.

植物源性生物活性肽（PBPs）具有多靶点抗衰老潜力，具有高安全性、结构多样性和可持续来源。然而，它们快速的胃肠道降解、较差的生物利用度和有限的组织特异性仍然是临床转化和功能食品开发的主要障碍。本文系统地综述了PBPs抗衰老作用的最新进展，重点阐述了其通过PI3K/Akt/mTOR、AMPK/SIRT1/PGC-1α和NF-κB等关键信号通路的分子机制。它还评估了先进的给药策略，包括纳米颗粒、脂质体、水凝胶、胶束和乳液，以及它们在通过各种给药途径（如口服、透皮、鼻和注射）提高稳定性、生物利用度和靶向效率方面的作用。特别关注刺激响应材料，三维打印和人工智能辅助设计等新兴技术，突出了它们在下一代精密交付平台中的应用前景。spbp通过协同调节抗氧化防御、免疫平衡、线粒体稳态、细胞凋亡、自噬和干细胞活性来发挥抗衰老作用。尽管给药技术的进步增强了药代动力学和药效学，但个性化、大规模和组织特异性的给药仍然具有挑战性。智能材料、多模态制造和人工智能驱动的预测相结合，为PBPs有效转化为健康衰老的功能食品和治疗剂提供了有希望的途径。

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引用次数: 0

Dietary strategies targeting steroid hormone metabolism: A nutritional modulation framework based on host-microbiota co-metabolic networks 针对类固醇激素代谢的饮食策略：基于宿主-微生物群共同代谢网络的营养调节框架

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-11-01 DOI: 10.1016/j.tifs.2025.105416

Zhihua Zhang , Yini Liu , Jianxin Zhao , Wei Chen , Gang Wang

Background

Endocrine metabolic syndrome (EMS) is driven by complex steroid hormone (SH) metabolism and metabolic dysregulation, posing serious threats to human health. SH have emerged as central mediators through multiple targets in EMS pathogenesis. Thus, thorough analysis of SH regulation mechanisms provides a theoretical foundation for targeted treatment and prevention strategies in EMS management.

Scope and approach

This review begins by outlining the metabolic sites, importance for human health, and influencing factors of SH metabolism, then discusses recent advances in host SH metabolism and its bidirectional interactions with gut microbiota (GM). Notably, specific diets can alter GM to modulate SH metabolism, thereby preventing and managing EMS. This review therefore focuses on providing a comprehensive overview of molecular pathways and mechanisms through which dietary strategies modulate SH metabolism via host-microbiota co-metabolic networks.

Key findings and conclusions

Dietary strategies encompassing dietary patterns and nutrients, bioactive compounds (polysaccharides, polyphenols, and bioactive peptides), and probiotics modulate SH metabolism by regulating the expression or activity of steroid-metabolising enzymes, whilst, reshaping GM structure and metabolic function. These findings underscore the importance of dietary interventions in modulating SH metabolism for EMS management.

背景dendocine metabolic syndrome （EMS）是由复杂的类固醇激素（SH）代谢和代谢失调驱动的疾病，严重威胁着人类的健康。SH在EMS发病过程中通过多个靶点成为中枢介质。因此，深入分析SH调控机制，为EMS管理中有针对性的治疗和预防策略提供理论基础。本文首先概述了促卵泡刺激素代谢的代谢位点、对人体健康的重要性和影响因素，然后讨论了宿主促卵泡刺激素代谢及其与肠道微生物群（GM）双向相互作用的最新进展。值得注意的是，特定的饮食可以改变转基因来调节SH代谢，从而预防和控制EMS。因此，本综述的重点是全面概述膳食策略通过宿主-微生物群共同代谢网络调节SH代谢的分子途径和机制。饮食策略包括饮食模式和营养素、生物活性化合物（多糖、多酚和生物活性肽）和益生菌，通过调节类固醇代谢酶的表达或活性来调节SH代谢，同时重塑转基因结构和代谢功能。这些发现强调了饮食干预在调节SH代谢对EMS管理的重要性。

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引用次数: 0

State-of-the-art insights into hydrogel innovations from structural engineering to smart preservation: Research trends and future directions 从结构工程到智能保存的水凝胶创新的最新见解：研究趋势和未来方向

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-11-01 DOI: 10.1016/j.tifs.2025.105411

Yan Xu , Yiyi Cheng , Tao Yang , Huizhi Chen , Ben Niu , Xiangjun Fang , Weijie Wu , Chaoyi Shen , Guannan Wang , Bangdi Liu , Ruiling Liu , Haiyan Gao

Background

The growing demand for sustainable food preservation technologies has spurred interest in composite hydrogels. By integrating natural and synthetic polymers, these materials offer improved mechanical properties, controlled release of active agents, and environmental compatibility—positioning them as promising alternatives to conventional preservation methods.

Scope and approach

This review systematically analyzes peer-reviewed literature published between 2015 and 2025, with particular emphasis on recent advances from 2020 onward. The review provides a comprehensive overview of recent advances in composite hydrogels, with emphasis on their structural design, functional characteristics, and applications across various food categories, including meat, aquatic products, fruits, and vegetables. Key functionalities such as moisture retention, microbial inhibition, and oxidative control are discussed, along with current challenges related to scalability, long-term stability, and regulatory approval.

Key findings and conclusions

Composite hydrogels exhibit significant potential in extending food shelf life by regulating moisture levels, inhibiting microbial growth, and delaying oxidative spoilage. Their adaptability allows for tailored solutions across diverse food matrices, contributing to reduced reliance on chemical preservatives and energy-intensive storage methods. Despite notable progress, further research is needed to optimize fabrication techniques, enhance stability, and ensure regulatory compliance. Future efforts should focus on developing scalable production methods, smart responsive systems, and integration with sustainable packaging platforms to support the advancement of eco-friendly food preservation technologies.

对可持续食品保鲜技术日益增长的需求激发了人们对复合水凝胶的兴趣。通过整合天然和合成聚合物，这些材料具有更好的机械性能、控制活性剂的释放和环境相容性，使其成为传统保存方法的有希望的替代品。本综述系统分析了2015年至2025年间发表的同行评议文献，特别强调了2020年以后的最新进展。本文综述了复合水凝胶的最新进展，重点介绍了复合水凝胶的结构设计、功能特性以及在肉类、水产品、水果和蔬菜等各种食品中的应用。讨论了保湿、微生物抑制和氧化控制等关键功能，以及与可扩展性、长期稳定性和监管批准相关的当前挑战。复合水凝胶通过调节水分水平、抑制微生物生长和延缓氧化变质，在延长食品保质期方面表现出巨大的潜力。它们的适应性允许针对不同食品基质定制解决方案，有助于减少对化学防腐剂和能源密集型储存方法的依赖。尽管取得了显著的进展，但需要进一步的研究来优化制造技术，提高稳定性，并确保法规遵从性。未来的努力应该集中在开发可扩展的生产方法，智能响应系统，以及与可持续包装平台的整合，以支持环保食品保鲜技术的进步。

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引用次数: 0

Microbial volatile organic compounds for food quality and safety: metabolic pathways, sampling and detection, and machine learning-driven insights 用于食品质量和安全的微生物挥发性有机化合物：代谢途径，采样和检测，以及机器学习驱动的见解

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-10-30 DOI: 10.1016/j.tifs.2025.105414

Lingchi Deng , Xue Zhao , Lin Chen

Background

Microbial spoilage and contamination pose persistent threats to food safety and quality. Microbial volatile organic compounds (mVOCs), generated during microbial metabolism, are emerging as non-invasive biomarkers that allow rapid and real-time assessment of food quality, spoilage, and pathogen activity.

Scope and approach

This review outlines the metabolic origins of mVOCs from carbohydrates, proteins, and lipids pathways and evaluates their roles in food quality and safety changes. Major sampling approaches, including headspace injection, solid-phase microextraction, purge-and-trap, and needle-trap, are compared alongside analytical platforms, such as GC-MS, GC-IMS, FTIR, and e-noses. Advances in data analytics, including PCA, machine learning, and deep learning, are also discussed for interpreting complex mVOCs datasets.

Key findings and conclusions

mVOCs provide sensitive, specific, and scalable indicators of microbial dynamics in food systems, with applications in fermentation monitoring, spoilage detection, and pathogen identification. Integration with modern analytical platforms and AI-driven modeling enhances interpretability and industrial value. However, key challenges remain: lack of standardized sampling protocols and calibration methods, limited cross-laboratory reproducibility, and poor model generalizability across food types and conditions. Future work should prioritize harmonized protocols, open benchmark datasets, and explainable AI frameworks, supported by cross-disciplinary collaboration, to enable reliable, real-time, and industry-ready mVOC-based monitoring.

微生物腐败和污染对食品安全和质量构成持续威胁。微生物挥发性有机化合物（mVOCs）是微生物代谢过程中产生的一种非侵入性生物标志物，可用于快速实时评估食品质量、腐败和病原体活性。本文概述了碳水化合物、蛋白质和脂质途径中多挥发性有机化合物的代谢来源，并评估了它们在食品质量和安全变化中的作用。主要的采样方法，包括顶空进样、固相微萃取、吹扫捕集和针捕集，与分析平台，如GC-MS、GC-IMS、FTIR和电子鼻进行了比较。本文还讨论了数据分析的进展，包括PCA、机器学习和深度学习，以解释复杂的mVOCs数据集。主要发现和结论：挥发性有机化合物提供了食品系统中微生物动态的敏感、特异性和可扩展的指标，在发酵监测、腐败检测和病原体鉴定方面具有广泛的应用。与现代分析平台和人工智能驱动的建模集成，增强了可解释性和工业价值。然而，关键的挑战仍然存在：缺乏标准化的采样方案和校准方法，有限的跨实验室可重复性，以及跨食品类型和条件的模型泛化性差。未来的工作应优先考虑协调协议、开放基准数据集和可解释的人工智能框架，并在跨学科协作的支持下，实现可靠、实时和行业就绪的基于mvoc的监测。

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引用次数: 0

Recent advances in MOFs based hydrogels: From interactions, synthesis, and functionalization to food applications 基于mof的水凝胶的最新进展：从相互作用、合成和功能化到食品应用

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-10-30 DOI: 10.1016/j.tifs.2025.105415

Xiaogang Dong , Minyi Fan , Lei Zhao , Kai Wang , Zhuoyan Hu , Xuwei Liu

Background

Environmental pollution and food safety issues have become increasingly serious. These problems call for safe, efficient, and multifunctional materials to contribute with monitoring, protection, and treatment. Traditional materials generally fall short in meeting the multifunctional and sustainable requirements of these emerging challenges. Therefore, novel hydrogels with inherent preservation capabilities urgently need to be developed to better meet food application requirements.

Scope and approach

The impacts of different types of Metal Organic Frameworks (MOFs) on the performance of hydrogel-based systems and their related applications are emphasized. The interaction mechanisms between MOFs and hydrogels are summarized. In addition, the practical applications of MOF-based hydrogels with different morphological structures are systematically classified and comprehensively discussed. It aims to offer a deeper understanding of their structure with performance correlations across diverse application scenarios.

Key findings and conclusions

MOF-based hydrogels offer a promising platform for addressing key challenges in food preservation and safety due to their tunable structure and multifunctional properties. The integration of MOFs into hydrogel matrices enhances mechanical strength, thermal stability, and responsiveness via coordination bonds and hydrogen bonding. These improvements support the development of intelligent systems capable of real-time freshness monitoring, removal of hazardous substances and application in antifreeze packaging for refrigerated foods.

环境污染和食品安全问题日益严重。这些问题需要安全、高效和多功能的材料来监测、保护和治疗。传统材料在满足这些新兴挑战的多功能和可持续要求方面通常不足。因此，迫切需要开发具有内在保存能力的新型水凝胶，以更好地满足食品应用需求。重点介绍了不同类型金属有机骨架对水凝胶体系性能的影响及其相关应用。综述了MOFs与水凝胶的相互作用机理。此外，对不同形态结构的mof基水凝胶的实际应用进行了系统的分类和全面的讨论。它的目的是更深入地了解它们的结构以及跨不同应用程序场景的性能相关性。基于smof的水凝胶由于其可调节的结构和多功能特性，为解决食品保存和安全中的关键挑战提供了一个有前景的平台。mof集成到水凝胶基质中，通过配位键和氢键增强了机械强度、热稳定性和响应性。这些改进支持智能系统的发展，能够实时监测新鲜度，去除有害物质，并应用于冷藏食品的防冻包装。

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引用次数: 0

Smart Shields: A conceptual approach to bridging surface functionality and self-healing for next-generation food packaging 4.0 智能屏蔽：连接表面功能和自我修复的概念方法，用于下一代食品包装4.0

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-10-29 DOI: 10.1016/j.tifs.2025.105413

Umme Habiba , Rahul Singh , Bhawana Jeena , Vinod Kumar , Alexey A. Dmitriev , Bhawna Bisht

Background

Conventional food packaging primarily functions as a passive barrier, offering limited protection against physical, chemical, or environmental stresses. However, with the advent of 4th industrial revolution (Industry 4.0), the field of food packaging is undergoing a significant transformation towards the adoption of active, multifunctional, and stimuli-responsive systems. This new era is known as Packaging 4.0 and is shaped by four essential pillars: innovative manufacturing processes, interactive product features, stronger consumer engagement, and a holistic focus on sustainability (environmental, economic, and social). These advanced packaging solutions provide real-time adaptability, enhanced durability, and extended functionality, thereby contributing to improved food safety, prolonged shelf life, and greater sustainability.

Scope and approach

This review explores a new approach to the development of "Smart Shields"— a new class of food packaging materials that integrate surface functionalization with self-healing capabilities. Surface functionalization introduces targeted features such as antimicrobial activity, controlled oxygen and moisture permeability, and environmental sensing. In parallel, self-healing mechanisms enable the material to autonomously repair physical damage, thereby preserving structural integrity and extending the functional lifespan of the packaging.

Conclusion

Bringing together these complementary strategies offers a promising path toward innovative food packaging that aligns with the goals of Packaging 4.0 and Industry 4.0. However, several important challenges still need to be addressed, such as ensuring material compatibility, developing scalable manufacturing methods, meeting regulatory requirements, and evaluating environmental impacts. Tackling these issues is essential for turning smart shield concepts into practical, market-ready solutions in the growing field of smart packaging.

传统的食品包装主要是作为一个被动的屏障，提供有限的保护，防止物理，化学或环境压力。然而，随着第四次工业革命（工业4.0）的到来，食品包装领域正在经历一场重大变革，朝着采用主动、多功能和刺激响应系统的方向发展。这个新时代被称为包装4.0，它由四个基本支柱构成：创新的制造工艺、互动式产品功能、更强的消费者参与以及对可持续性（环境、经济和社会）的全面关注。这些先进的包装解决方案提供实时适应性，增强耐用性和扩展功能，从而有助于提高食品安全性，延长保质期和更大的可持续性。本综述探讨了一种开发“智能屏蔽”的新方法——一种将表面功能化与自修复能力相结合的新型食品包装材料。表面功能化引入了目标特性，如抗菌活性，控制氧气和水分的渗透性，以及环境传感。同时，自修复机制使材料能够自主修复物理损伤，从而保持结构完整性并延长包装的功能寿命。将这些互补策略结合在一起，为创新食品包装提供了一条有希望的道路，与包装4.0和工业4.0的目标保持一致。然而，仍有几个重要的挑战需要解决，例如确保材料兼容性，开发可扩展的制造方法，满足法规要求以及评估环境影响。解决这些问题对于将智能屏蔽概念转化为日益增长的智能包装领域的实用，市场就绪的解决方案至关重要。

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引用次数: 0

Synthetic biology and protein processing engineering-driven microbial protein supply by yeast and filamentous fungi 合成生物学和蛋白质加工工程——酵母和丝状真菌驱动的微生物蛋白质供应

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-10-28 DOI: 10.1016/j.tifs.2025.105408

Xinhong Wu , Yaokang Wu , Xueqin Lv , Jianghua Li , Long Liu , Guocheng Du , Jian Chen , Yanfeng Liu

Background

With high production efficiency and sustainability, microbial protein offers an effective and environmentally friendly alternative that is independent of conventional agriculture and animal husbandry to meet increasing food protein demand. Yeast and filamentous fungi biomass-based proteins are important microbial protein with wide applications. The integration of synthetic biology and protein processing engineering is pivotal for enhancing the production and quality of these proteins.

Scope and approach

This review critically synthesizes recent advances in leveraging synthetic biology and protein processing engineering to overcome key challenges in fungal protein production. It specifically examines how synthetic biology tools—including CRISPR-based genome editing and in vivo continuous evolution—are employed to create high-efficiency production strains by redirecting metabolic fluxes. Furthermore, it analyzes how protein processing engineering modulates physicochemical and textural properties to improve product quality and functionality.

Key findings and conclusions

The analysis demonstrates that the synergistic integration of synthetic biology and processing engineering is essential for advancing fungal protein from promise to practice. Looking forward, we conclude that the field will be transformed by several key strategies: AI-assisted design to accelerate engineering cycles; purpose-driven strain libraries to ensure industrial robustness; and integrated fermentation-extraction processes to preserve functionality. This review provides a strategic framework to guide the development of next-generation fungal-based foods, from foundational strain engineering to final product application.

微生物蛋白具有较高的生产效率和可持续性，是一种独立于传统农业和畜牧业的有效和环保的替代方案，可满足日益增长的食品蛋白质需求。酵母和丝状真菌生物量蛋白是重要的微生物蛋白，具有广泛的应用前景。合成生物学和蛋白质加工工程的结合对提高这些蛋白质的产量和质量至关重要。范围和方法这篇综述批判性地综合了利用合成生物学和蛋白质加工工程来克服真菌蛋白质生产中的关键挑战的最新进展。它特别研究了合成生物学工具-包括基于crispr的基因组编辑和体内连续进化-如何通过重定向代谢通量来创造高效的生产菌株。此外，还分析了蛋白质加工工程如何调节理化和结构特性以提高产品质量和功能。分析表明，合成生物学和加工工程的协同整合是促进真菌蛋白从希望到实践的必要条件。展望未来，我们得出结论，该领域将通过以下几个关键策略进行变革：人工智能辅助设计，加快工程周期；目的驱动的应变库，确保工业稳健性；和集成的发酵提取过程，以保持功能。这篇综述为指导下一代真菌食品的发展提供了一个战略框架，从基础菌株工程到最终产品应用。

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引用次数: 0

Integrating biosynthesis insights with biotechnological potential of bioactive carotenoids in food systems 将生物活性类胡萝卜素在食品系统中的生物合成见解与生物技术潜力相结合

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-10-28 DOI: 10.1016/j.tifs.2025.105410

Md Mohsin Patwary , YeEn Kim , Saji George , Codruta Ignea

Background

Carotenoids, a class of natural compounds in the terpenoid family, are known for their bioactivity and ability to improve human health, and are thus extensively linked to food applications. While current sourcing of carotenoids is principally synthetic, consumers show a strong preference for natural carotenoids, which has driven the growth of carotenoid production via microbial fermentation using algae, bacteria or yeast platforms.

Scope and approach

By bridging advanced biosynthetic machinery with formulation science, this review critically examines the translational potential of microbial carotenoids as multifunctional ingredients in future food products.

Key findings and conclusions

Recent advances in metabolic engineering and synthetic biology have enabled efficient production of commonly utilized carotenoids, such as astaxanthin and β-carotene, and demonstrated proof-of-concept for engineering rare or new-to-nature carotenoids with potential biological activities in microbial hosts. Current developments include strategies for targeted engineering of biosynthetic pathways and precursor supply, and encapsulation technologies for enhancing the bioavailability and stability of carotenoids in functional foods. Nevertheless, biotechnological production of carotenoids and associated downstream processing approaches face both challenges and prospects in scaling up to industrial production.

类胡萝卜素是萜类化合物家族中的一类天然化合物，以其生物活性和改善人体健康的能力而闻名，因此与食品应用广泛相关。虽然目前类胡萝卜素的来源主要是合成的，但消费者对天然类胡萝卜素表现出强烈的偏好，这推动了利用藻类、细菌或酵母平台通过微生物发酵生产类胡萝卜素的增长。范围和方法通过将先进的生物合成机械与配方科学相结合，本文综述了微生物类胡萝卜素作为多功能成分在未来食品中的转化潜力。代谢工程和合成生物学的最新进展使虾青素和β-胡萝卜素等常用类胡萝卜素的高效生产成为可能，并证明了在微生物宿主中具有潜在生物活性的稀有或新天然类胡萝卜素的工程概念。目前的发展包括生物合成途径和前体供应的靶向工程策略，以及提高功能性食品中类胡萝卜素的生物利用度和稳定性的封装技术。然而，类胡萝卜素的生物技术生产和相关的下游加工方法在扩大工业化生产方面面临挑战和前景。

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引用次数: 0

Recent advances and strategies in cultured satellite cell cultivation for efficient cultured meat production: A review 人造卫星细胞高效养殖肉制品的研究进展及对策综述

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology

Pub Date : 2025-10-28 DOI: 10.1016/j.tifs.2025.105409

Dong Bin Kim , Hyo Jin Lee , Hye Won Lee , Ho Gun Jang , Jong Hyuk Kim , Sun Jin Hur , Da Young Lee , Seon-Tea Joo , Sang-Eun Jung , Seung Yun Lee

Background

Cultured meat, a branch of cellular agriculture, has emerged as a sustainable protein source alternative that potentially addresses the growing global population and environmental concerns related to traditional meat production. Myoblasts, the progeny of satellite cells, are essential for cultured meat as they can proliferate and differentiate into muscle tissue in vitro. Optimizing the culture conditions and replacing animal-derived materials, such as fetal bovine serum (FBS), is a key challenge to enable scalable production.

Scope and approach

This review synthesizes recent studies from 2020 to 2025 on the isolation, culture, and scale-up of cultured satellite cells from various species. It explores enzymatic and sorting techniques for efficient satellite cell isolation; evaluates basal media and coating materials; and highlights alternatives to FBS, including animal-, plant-, insect-, and microalgae-derived supplements. Culture parameters, such as temperature, oxygen level, and growth factors, are analyzed to guide optimization strategies.

Key findings and conclusions

Efficient cultured satellite cell expansion requires species-specific enzymatic isolation and surface marker-based sorting, along with appropriate growth factors and substrates. Several FBS substitutes demonstrate promising potential; however, complete replacement remains a challenge. Bioreactor-based scale-up strategies are requisite to satisfying industrial demand, while economic and ethical considerations are set to drive future innovations. This review provides a comprehensive framework for advancing satellite cell technology toward feasible cultured meat production.

作为细胞农业的一个分支，人造肉已经成为一种可持续的蛋白质来源替代品，有可能解决与传统肉类生产相关的全球人口增长和环境问题。成肌细胞是卫星细胞的后代，对人造肉至关重要，因为它们可以在体外增殖并分化成肌肉组织。优化培养条件和替代动物源性材料，如胎牛血清（FBS），是实现规模化生产的关键挑战。本文综述了从2020年到2025年关于不同物种卫星细胞的分离、培养和规模化培养的最新研究。它探讨了有效的卫星细胞分离的酶和分选技术；评估基础介质和涂层材料；并强调了FBS的替代品，包括动物、植物、昆虫和微藻来源的补充剂。培养参数，如温度，氧气水平和生长因子，分析指导优化策略。培养卫星细胞的高效扩增需要物种特异性酶分离和基于表面标记的分选，以及合适的生长因子和底物。几种FBS替代品显示出良好的潜力；然而，完全替换仍然是一个挑战。以生物反应器为基础的规模化战略是满足工业需求的必要条件，而经济和伦理方面的考虑将推动未来的创新。这一综述为推进卫星细胞技术向可行的养殖肉生产方向发展提供了全面的框架。

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