Background
Individuals born between 1980 and 1999 represent the first cohort to fully experience digital transformation, rapid industrialization, and medical advancements, yet they face unprecedented health paradoxes, including potential longevity gains overshadowed by novel environmental and lifestyle-related risks. These challenges encompass neurological, metabolic, reproductive, and multi-system disruptions driven by modern exposures.
Objective
This review systematically examines the distinctive health risks, underlying pathophysiological mechanisms, and innovative medical technologies poised to mitigate these issues over the next 1-2 decades.
Methods
A comprehensive literature search was conducted across databases including PubMed, Web of Science, Scopus, and CNKI, using keywords such as "post-80s generation," "circadian disruption," "ultra-processed foods," "microplastics," and "stem cell therapy," published from 2000 to 2025. Inclusion criteria focused on peer-reviewed studies providing empirical evidence on risks or interventions, with screening yielding 199 articles after de-duplication and quality appraisal.
Results
This generation confronts chronic neurological dysfunction from digital-induced circadian disruption, metabolic dysregulation and reproductive decline from ultra-processed foods and additive overload, and environmental toxins like microplastics. Emerging technologies show promise, including stem cell therapy, organoid platforms for personalized modeling, gut microbiome modulation for metabolic restoration, precision-targeted therapeutics for disease-specific interventions, modernized phytomedicine for natural anti-inflammatory effects, and exosome-based therapies for non-invasive delivery. Integration with multi-omics monitoring enables early detection and proactive management.
Conclusions
Systematic adoption of these technologies and comprehensive health monitoring frameworks could enable sustained healthy longevity for this generation. This synthesis catalyzes a shift from reactive disease management to proactive optimization, offering actionable insights for individuals, clinicians, and policymakers.
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