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Health challenges and frontier solutions for the post-80s and post-90s generation 80、90后健康挑战与前沿解决方案
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-14 DOI: 10.1016/j.tifs.2026.105563
Qing Xia , Kang Zou

Background

Individuals born between 1980 and 1999 represent the first cohort to fully experience digital transformation, rapid industrialization, and medical advancements, yet they face unprecedented health paradoxes, including potential longevity gains overshadowed by novel environmental and lifestyle-related risks. These challenges encompass neurological, metabolic, reproductive, and multi-system disruptions driven by modern exposures.

Objective

This review systematically examines the distinctive health risks, underlying pathophysiological mechanisms, and innovative medical technologies poised to mitigate these issues over the next 1-2 decades.

Methods

A comprehensive literature search was conducted across databases including PubMed, Web of Science, Scopus, and CNKI, using keywords such as "post-80s generation," "circadian disruption," "ultra-processed foods," "microplastics," and "stem cell therapy," published from 2000 to 2025. Inclusion criteria focused on peer-reviewed studies providing empirical evidence on risks or interventions, with screening yielding 199 articles after de-duplication and quality appraisal.

Results

This generation confronts chronic neurological dysfunction from digital-induced circadian disruption, metabolic dysregulation and reproductive decline from ultra-processed foods and additive overload, and environmental toxins like microplastics. Emerging technologies show promise, including stem cell therapy, organoid platforms for personalized modeling, gut microbiome modulation for metabolic restoration, precision-targeted therapeutics for disease-specific interventions, modernized phytomedicine for natural anti-inflammatory effects, and exosome-based therapies for non-invasive delivery. Integration with multi-omics monitoring enables early detection and proactive management.

Conclusions

Systematic adoption of these technologies and comprehensive health monitoring frameworks could enable sustained healthy longevity for this generation. This synthesis catalyzes a shift from reactive disease management to proactive optimization, offering actionable insights for individuals, clinicians, and policymakers.
1980年至1999年间出生的人是第一批全面体验数字化转型、快速工业化和医疗进步的人群,但他们面临着前所未有的健康悖论,包括潜在的寿命增长被新的环境和生活方式相关风险所掩盖。这些挑战包括现代暴露导致的神经、代谢、生殖和多系统破坏。目的:本综述系统地研究了不同的健康风险,潜在的病理生理机制,以及未来1-2年有望缓解这些问题的创新医疗技术。方法对2000 - 2025年间发表的PubMed、Web of Science、Scopus、CNKI等数据库进行综合文献检索,检索关键词为“80后”、“昼夜节律中断”、“超加工食品”、“微塑料”、“干细胞治疗”等。纳入标准侧重于提供有关风险或干预措施的经验证据的同行评议研究,经过重复删除和质量评估,筛选产生199篇文章。这一代人面临着由数字诱发的昼夜节律紊乱引起的慢性神经功能障碍,超加工食品和添加剂过量导致的代谢失调和生殖衰退,以及微塑料等环境毒素。新兴技术显示出前景,包括干细胞治疗、用于个性化建模的类器官平台、用于代谢恢复的肠道微生物组调节、用于疾病特异性干预的精确靶向治疗、用于天然抗炎作用的现代化植物医学,以及用于非侵入性输送的基于外泌体的治疗。与多组学监测的集成可实现早期检测和主动管理。结论系统采用这些技术和全面的健康监测框架可以使这一代人持续健康长寿。这种综合催化了从被动疾病管理到主动优化的转变,为个人、临床医生和政策制定者提供了可操作的见解。
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引用次数: 0
Co-Biotics - Dual modulation of the host and the microbiota 共生生物-宿主和微生物群的双重调节
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-14 DOI: 10.1016/j.tifs.2026.105561
James Versalovic , Eran Segal , Emeran A. Mayer , Glenn R. Gibson , Lorenzo Morelli , Gregor Reid

Background

Current health interventions, including food ingredients, bioactive compounds and dietary supplements that act through the gut microbiome, can support whole-body health as well as provide metabolic effects and energy functions. Product examples include probiotics, prebiotics, synbiotics, postbiotics and fermented foods, all well defined by expert panels. However, the term co-biotics has recently appeared in scientific publications and commerce without a definition or clarity.

Scope and approach

We performed a literature and product review with the goal of identifying how the term co-biotics was being used. We then assessed it within the context of other microbiome-based biotics.

Key findings and conclusions

With the aim of bringing clarity to the field, we propose that co-biotics are defined as “A compound that simultaneously modulates biological processes in both the host and resident microbiota, to confer a health benefit". This covers a unique dual targeting of host cells and the gut microbiome, allowing for enhanced function and health promoting effects. We illustrate how to develop future co-biotics, as differentiated from other defined biotics, and discuss delivery requirements.
目前的健康干预措施,包括通过肠道微生物群起作用的食品成分、生物活性化合物和膳食补充剂,可以支持全身健康,并提供代谢作用和能量功能。产品示例包括益生菌、益生元、合成菌、后益生菌和发酵食品,所有这些都由专家小组明确定义。然而,“共生菌”一词最近出现在科学出版物和商业中,却没有一个明确的定义。范围和方法我们进行了文献和产品回顾,目的是确定如何使用术语共生剂。然后,我们在其他基于微生物组的生物制剂的背景下对其进行了评估。主要发现和结论为了使该领域更加清晰,我们建议将共生菌定义为“一种同时调节宿主和常驻微生物群的生物过程并赋予健康益处的化合物”。这涵盖了宿主细胞和肠道微生物组的独特双重靶向,允许增强功能和促进健康的效果。我们将说明如何开发未来的共生剂,以区别于其他已定义的生物制剂,并讨论交付要求。
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引用次数: 0
Marine biomaterials for advanced food packaging: From sourcing to intelligent functional design and commercial prospects 先进食品包装用海洋生物材料:从采购到智能功能设计和商业前景
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-13 DOI: 10.1016/j.tifs.2026.105560
Cheng Wang , Mengru Zhang , Tong Zhang , Haitao Du , Hongmin Xia , Renwei Guan , Fengdan Guo , Xinyi Li , Mingming Wang , Xiuwen Jia , Ping Wang

Background

The persistent environmental impact of conventional petroleum-based plastic packaging, has intensified the need for sustainable alternatives. Marine biological resources provide renewable, biodegradable, and functionally diverse materials for next-generation food packaging. These biomolecules exhibit inherent properties suitable for developing active and intelligent packaging systems that can extend shelf life and monitor food quality in real time.

Scope and approach

In this review, the sources and functional design of marine-derived biomaterials in food packaging are comprehensively analyzed and discussed. It encompasses the extraction and utilization of key marine biopolymers, the design strategies for active (antimicrobial, antioxidant, and antiviral) and intelligent (pH-, gas-, and temperature-responsive) packaging materials, and their role in enhancing sensory characteristics and environmental sustainability. Based on this foundation, the commercialization trends and challenges of marine biomaterials are subsequently analyzed and discussed.

Key findings and conclusions

Marine-derived packaging materials represent a transformative alternative to petroleum-based materials. By leveraging the inherent properties of marine-derived packaging materials and integrating pH-, gas-, and temperature-responsive or other components into them through composite fabliulirication, they can achieve multifunctionality, which collectively improves food safety, shelf life, and sensory qualities. However, marine-derived packaging materials are limited by several challenges. To achieve their commercialization, cost efficiency, regulatory standards, and material consistency must be addressed. The integration of emerging technologies, such as Artificial Intelligence (AI)-driven design and four-dimensional (4D) printing, can accelerate intelligent, responsive packaging systems. Ultimately, marine biomaterials will be pivotal in transitioning toward a blue circular economy.
传统石油基塑料包装对环境的持续影响加剧了对可持续替代品的需求。海洋生物资源为下一代食品包装提供了可再生、可生物降解和功能多样化的材料。这些生物分子表现出固有的特性,适合开发主动和智能包装系统,可以延长保质期和实时监控食品质量。本文对海洋生物材料在食品包装中的来源和功能设计进行了全面的分析和探讨。它包括关键海洋生物聚合物的提取和利用,活性(抗菌、抗氧化和抗病毒)和智能(pH、气体和温度响应)包装材料的设计策略,以及它们在增强感官特性和环境可持续性方面的作用。在此基础上,对海洋生物材料的商业化趋势和面临的挑战进行了分析和讨论。主要发现和结论:海洋衍生包装材料代表了石油基材料的一种变革性替代品。通过利用海洋源包装材料的固有特性,并通过复合加工将pH,气体和温度响应或其他成分整合到其中,它们可以实现多功能,从而共同提高食品安全性,保质期和感官质量。然而,海洋来源的包装材料受到几个挑战的限制。为了实现它们的商业化,必须解决成本效率、监管标准和材料一致性问题。新兴技术的整合,如人工智能(AI)驱动的设计和四维(4D)打印,可以加速智能,响应包装系统。最终,海洋生物材料将成为向蓝色循环经济过渡的关键。
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引用次数: 0
Tailoring plant protein-polysaccharide emulsions: Unveiling mechanisms from structure to function for advanced food systems 裁剪植物蛋白-多糖乳剂:揭示先进食物系统从结构到功能的机制
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-13 DOI: 10.1016/j.tifs.2026.105559
Qinqiu Zhang , Qing Zhang , Yijie Ren , Jingming Li , Song Miao , Wen Qin

Background

Global clean labelling and the plant-based food surge have made plant protein-polysaccharide emulsions (PPPEs) a research frontier. Yet key challenges remain, including limited interfacial activity, sensitivity to environmental conditions, and unpredictable digestion. Unlocking the multi-scale mechanisms is now essential to create precise controls and drive sustainable food innovation.

Scope and approach

This review consolidates recent advances in PPPEs. It examines various preparation methods, including high-pressure homogenization, microfluidics, and various phase inversions. The analysis focuses on linking structural attributes (such as particle size, interfacial charge) to functional properties (such as stability, rheology), ultimately discussing their applications in advanced food systems.

Key findings and conclusions

The central challenge for PPPEs lies in precisely controlling their interfacial architecture. To unlock this, we must integrate molecular dynamics simulations with in situ characterization to unveil the orientation, conformation, and interactions of interface particles. Furthermore, research on the gastrointestinal fate of these emulsions remains nascent. Systematic investigation into their structural evolution during digestion, coupled with kinetic modeling, is essential to bridge this gap and ultimately predict their functional behavior.
全球清洁标签和植物性食品的兴起使植物蛋白多糖乳剂(PPPEs)成为研究的前沿。然而,关键的挑战仍然存在,包括有限的界面活性、对环境条件的敏感性和不可预测的消化。解锁多尺度机制现在对于创建精确控制和推动可持续食品创新至关重要。范围和方法本综述总结了pppe的最新进展。它检查了各种制备方法,包括高压均质,微流体,和各种相反转。分析的重点是将结构属性(如粒度、界面电荷)与功能属性(如稳定性、流变性)联系起来,最终讨论它们在先进食品系统中的应用。关键发现和结论pppe的核心挑战在于精确控制其接口架构。为了解开这个问题,我们必须将分子动力学模拟与原位表征相结合,以揭示界面粒子的取向、构象和相互作用。此外,对这些乳剂的胃肠道命运的研究仍处于起步阶段。系统地研究它们在消化过程中的结构演变,再加上动力学建模,对于弥合这一差距并最终预测它们的功能行为至关重要。
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引用次数: 0
Advances in Hyperspectral Imaging for Spoilage Detection in Meat and Poultry: A Non-Invasive Approach 高光谱成像在肉类和家禽腐败检测中的研究进展:一种无创方法
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-11 DOI: 10.1016/j.tifs.2026.105558
Zincia Sherin , Omar Bashir , Imdadul Hoque Mondal , Prashant Anil Pawase

Background

Meat and poultry are among the most highly perishable food commodities, and their rapid deterioration presents significant challenges to food safety, quality assurance, and economic sustainability. Conventional spoilage detection methods, including microbiological and chemical assays, remain reliable; however, they are often destructive, time-consuming, and unsuitable for real-time monitoring applications.

Scope and approach

Hyperspectral imaging (HSI) has become a prospective non-invasive technology that could be used in the simultaneous spatial and spectral data collection of the meat surface, offering in-depth information on chemical and microbial transformations. The present review is based on the current use of HSI in the process of monitoring microbial activity, identifying chemical indicators, including total volatile basic nitrogen (TVB-N), Thiobarbituric Acid Reactive Substances (TBARS), and pH changes, and measuring visible changes in colour and texture. Special attention is given to the combination of HSI and chemometric methods and state-of-the-art machine learning models, such as principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), convolutional neural networks (CNNs), long short-term memory networks (LSTMs), and autoencoders.

Key findings and conclusion

HSI has proven to be very accurate in the early detection of spoilage, in most instances better than conventional means. New innovations, including creation of portable HSI units, artificial intelligence, and multimedia systems that combine HSI and other sensors or internet of things, have expanded its application potential. Nevertheless, there are still notable issues, such as managing massive amounts of data, high prices of equipment, and the lack of uniform protocols to implement in industries. Future studies must aim at minimizing the size of the devices, creation of strong calibration systems, and the ease of incorporation into smart food devices. Together, these developments make HSI a future-proof, non-destructive, and dependable technology to assess the quality and safety of modern meat. This review further demonstrates that hybrid VIS-NIR-SWIR configurations combined with interpretable chemometric and machine-learning models consistently outperform single-range systems, while the lack of standardized validation and regulatory frameworks remains the primary barrier to large-scale industrial adoption.
肉类和家禽是最易腐烂的食品商品之一,它们的快速变质对食品安全、质量保证和经济可持续性提出了重大挑战。传统的腐败检测方法,包括微生物和化学分析,仍然是可靠的;然而,它们通常是破坏性的,耗时的,并且不适合实时监控应用程序。高光谱成像(HSI)已成为一种有前景的非侵入性技术,可用于同时收集肉类表面的空间和光谱数据,提供有关化学和微生物转化的深入信息。目前的综述是基于目前HSI在监测微生物活动,确定化学指标,包括总挥发性碱性氮(TVB-N),硫代巴比妥酸反应物质(TBARS)和pH变化以及测量颜色和质地的可见变化过程中的使用。特别关注HSI和化学计量学方法以及最先进的机器学习模型的结合,如主成分分析(PCA),偏最小二乘判别分析(PLS-DA),卷积神经网络(cnn),长短期记忆网络(LSTMs)和自编码器。hsi已被证明在早期发现腐败方面非常准确,在大多数情况下比传统方法更好。新的创新,包括便携式HSI单元的创建,人工智能以及将HSI与其他传感器或物联网相结合的多媒体系统,扩大了其应用潜力。然而,仍然存在一些值得注意的问题,例如管理大量数据,设备价格高,以及缺乏统一的协议来实施行业。未来的研究必须致力于使设备的尺寸最小化,创建强大的校准系统,以及易于集成到智能食品设备中。总之,这些发展使HSI成为一种面向未来的、非破坏性的、可靠的技术,用于评估现代肉类的质量和安全。该综述进一步表明,混合VIS-NIR-SWIR配置与可解释的化学计量学和机器学习模型相结合,始终优于单范围系统,而缺乏标准化验证和监管框架仍然是大规模工业应用的主要障碍。
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引用次数: 0
Smart drying of agricultural produce: An industry 4.0 perspective 农产品智能干燥:工业4.0视角
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-10 DOI: 10.1016/j.tifs.2026.105557
Jijnasha Bal, V. Kavan Kumar, Narayan Lal Panwar

Background

Internet of Things (IoT) integration facilitates modular sensor deployment and edge-level embedded systems decision-making, while cloud platforms support remote diagnostics and predictive analytics. Machine learning models has supported adaptive control, moisture prediction, and anomaly detection. Digital twins and further enhance simulation accuracy and operational resilience. Despite these advancements, challenges persist in sensor calibration, connectivity, data security, and standardization, particularly in rural deployments.

Scope

IoT enabled framework into agricultural food drying systems is creating a major change in how post-harvest management is handled, connecting current framework of Industry 4.0 principles with the goals of Industry 5.0. This synthesis reviews the development, system architecture, and practical uses of IoT in food drying as a core component of Industry 4.0, stressing its positive impact on energy efficiency, maintaining product quality, and automating processes.

Key findings and conclusion

The paper identifies future directions, including multimodal sensing, blockchain-enabled traceability, and edge AI for autonomous control. By integrating IoT with sustainable engineering and intelligent analytics, the drying of agricultural food materials can be revolutionised to meet global demands for food security, energy conservation, and climate resilience. This review provides a comprehensive roadmap for researchers and practitioners aiming to develop scalable, intelligent, and inclusive drying technologies for the next generation of smart agriculture.
物联网(IoT)集成有助于模块化传感器部署和边缘级嵌入式系统决策,而云平台支持远程诊断和预测分析。机器学习模型支持自适应控制、湿度预测和异常检测。数字孪生和进一步提高模拟精度和操作弹性。尽管取得了这些进步,但在传感器校准、连接、数据安全和标准化方面仍然存在挑战,特别是在农村部署方面。将ScopeIoT框架应用到农业食品干燥系统中,将工业4.0原则的当前框架与工业5.0的目标联系起来,为收获后管理的处理方式带来了重大变化。本文综述了作为工业4.0核心组成部分的物联网在食品干燥中的发展、系统架构和实际应用,强调了其对能源效率、保持产品质量和自动化过程的积极影响。本文确定了未来的方向,包括多模态传感、支持区块链的可追溯性和用于自主控制的边缘人工智能。通过将物联网与可持续工程和智能分析相结合,农业食品材料的干燥可以发生革命性变化,以满足全球对粮食安全、节能和气候适应能力的需求。这篇综述为研究人员和实践者提供了一个全面的路线图,旨在为下一代智能农业开发可扩展的、智能的、包容性的干燥技术。
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引用次数: 0
Global patent landscape of marine functional foods: Technological trends, hotspots, and future challenges 全球海洋功能食品专利格局:技术趋势、热点和未来挑战
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.tifs.2026.105555
Wei Guo , Haitao Wang , Yihua Bai , Mingqian Tan

Background

Global health awareness is on the rise, driving transformation and upgrading in the food industry. Marine functional foods have thus emerged as a prominent focus in food and biotechnology applications. Their richness in bioactive compounds and unique health-promoting properties are key drivers behind this trend. Patents serve as important indicators of technological innovation. They provide valuable insights into development trends and the competitive landscape. Therefore, patent analysis plays a crucial role in fostering innovation within the marine functional foods industry.

Scope and approach

Global patent data of marine functional foods from 2005 to 2024 was collected in this study. The global patent landscape of marine functional foods was delineated by integrating patent data mining, patent mapping, and in-depth patent analysis. The technological trends, research hotspots, and future challenges were uncovered for marine functional foods.

Key findings and conclusions

The technological life cycle of marine functional foods was in the growth phase. Marine active component extraction and purification was achieved with supercritical fluid extraction, enzyme hydrolysis-membrane separation, and microbial fermentation transformation. Health functional enhancement methods were established through microencapsulation, liposome encapsulation, and nanodelivery systems. Precision nutrition and health was explored by multi-omics, phenotyping collection, personalized recommendation system, and compound nutrient formulation. The gap between innovation and commercialization, constraints within the bio-manufacturing paradigm, and the lack of unified global standards remain prominent challenges for the marine functional foods industry. Future efforts will require collaborative innovation, sustainable development, and establishing technology to drive industry growth.
全球健康意识不断增强,推动着食品行业的转型升级。因此,海洋功能食品已成为食品和生物技术应用的一个突出焦点。它们丰富的生物活性化合物和独特的健康促进特性是这一趋势背后的关键驱动因素。专利是技术创新的重要指标。它们提供了有关发展趋势和竞争格局的宝贵见解。因此,专利分析在促进海洋功能食品行业的创新中起着至关重要的作用。本研究收集了2005年至2024年全球海洋功能食品的专利数据。通过专利数据挖掘、专利图谱绘制和深度专利分析,勾勒出全球海洋功能食品专利格局。揭示了海洋功能食品的技术发展趋势、研究热点和未来面临的挑战。主要发现与结论海洋功能食品的技术生命周期处于生长期。采用超临界流体萃取、酶解-膜分离、微生物发酵转化等工艺对海洋活性成分进行提取纯化。通过微囊化、脂质体囊化和纳米递送系统建立了增强健康功能的方法。通过多组学、表型收集、个性化推荐系统、复合营养配方等探索精准营养与健康。创新与商业化之间的差距、生物制造范式的限制以及缺乏统一的全球标准仍然是海洋功能食品行业面临的突出挑战。未来的努力将需要协同创新、可持续发展和建立技术来推动行业增长。
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引用次数: 0
Research progress in microbial synthesis of D-allulose using metabolically engineered microbes 代谢工程微生物合成D-allulose的研究进展
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.tifs.2026.105551
Junchi Zhu , Like Fan , Jiajun Chen , Wei Xu , Azis Boing Sitanggang , Fina Amreta Laksmi , Junmei Ding , Wanmeng Mu

Background

D-Allulose is a functional low-calorie sugar with a huge market potential. Industrial production of D-allulose mainly relies on the reversible enzymatic epimerization of D-fructose by D-allulose 3-epimerase (DAEase). Recently, various microbes have been engineered to produce D-allulose efficiently through microbial fermentation.

Scope and approach

Four typical types of microbial of D-allulose synthesis are reviewed, including DAEase-based, epimerization/hydrogenation/dehydrogenation-based, aldol reaction/dephosphorylation-based, and phosphorylation/epimerization/dephosphorylation-based biosynthesis.

Key findings and conclusions

Introduction of DAEase and deletion of D-fructose catabolism pathway easily achieves the D-allulose production from D-fructose, but it does not change the reversibility of epimerization. The introduction of specific hydrogenation and dehydrogenation enzymes can drive D-allulose synthesis using allitol as an intermediate. A programmable bidirectional dynamic switch has been designed to highly-efficiently produce D-allulose from D-fructose. Aldol reaction and dephosphorylation modules can be introduced into microbes to produce D-allulose from glycerol; however, a considerable amount of D-sorbose is generated as a byproduct. Phosphorylation/epimerization/dephosphorylation pathway can be introduced into microbes to produce D-allulose from D-fructose, D-glucose, D-xylose, glycerol, or sucrose. The pathways of various carbon sources toward D-fructose-6-phosphate are respectively designed and epimerization-dephosphorylation is introduced to thermodynamically driven production of D-allulose from D-fructose-6-phosphate.
背景-铝合金糖是一种具有巨大市场潜力的功能性低热量糖。工业生产D-allulose主要依赖于D-allulose 3- epimase (DAEase)对d -果糖的可逆酶外聚反应。近年来,各种微生物已经通过微生物发酵有效地生产D-allulose。综述了四种典型的微生物合成D-allulose的方法,包括基于daase的、基于外映异构/氢化/脱氢的、基于醛醇反应/去磷酸化的、基于磷酸化/外映异构/去磷酸化的生物合成。主要发现和结论引入DAEase和删除d -果糖分解代谢途径可使d -果糖生成D-allulose,但不改变外显异构化的可逆性。引入特定的加氢和脱氢酶可以驱动以allitol为中间体合成D-allulose。设计了一种可编程的双向动态开关,以高效地从d -果糖中产生D-allulose。Aldol反应和去磷酸化模块可以引入微生物,从甘油生产D-allulose;然而,相当数量的d -海马糖是作为副产品产生的。磷酸化/外映体化/去磷酸化途径可以引入微生物,从d -果糖、d -葡萄糖、d -木糖、甘油或蔗糖中产生D-allulose。设计了不同碳源制备d -果糖-6-磷酸的途径,并将外聚-去磷酸化引入到d -果糖-6-磷酸热驱动生产D-allulose的过程中。
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引用次数: 0
Engineered biosensor-driven food biomanufacturing: Intelligent multi-scale systems for nutrient synthesis monitoring and quality control 工程生物传感器驱动的食品生物制造:用于营养合成监测和质量控制的智能多尺度系统
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.tifs.2026.105552
Xinya Mo , Wen Zhu , Shutong Zhang , Zhuoning Cao , Qiang Zhao , Hao Dong , Hong Jiang , Jianan Sun , Sai Wang , Xiangzhao Mao

Background

Food biomanufacturing represents a transformative solution addressing both global nutrition and sustainability challenges through synthetic biology techniques. Engineered biosensors have emerged as pivotal tools enabling intelligent and multi-scale process monitoring and quality control in this domain.

Scope and approach

This review highlights recent biosensor innovations in food synthetic biology, covering rational design, technological advances, and real-world implementation frameworks. Fundamental investigation was conducted in the Web of Science database covering nearly five years, employing keywords including “nutrients”, “food”, “biosensors” and “biosynthesis”. Subsequently, a screening process was applied to the retrieved results, with the objective of identifying studies concerning food substances.

Key findings and conclusions

Existing biosensors leverage three core transduction mechanisms, i.e., cell-growth-coupled, optical and electrochemical, facilitating production of over 40 critical nutrients (e.g., amino acids, sugars, and phospholipids), via accelerating high-throughput strain and enzyme optimization, dynamic regulation of biosynthetic pathways, and sensitive quantitation of target nutrients. The biosensors assist to yield over 27 optimized strains/enzymes, with dynamic control boosting production up as high as 27-fold and limit of detection reaching as low as 44.46 pmol/L. Future food biomanufacturing will integrate AI-optimized, multiplexing, smart biosensors, and cross-species platforms to redefine the precision and sustainability benchmarks of next-generation food biomanufacturing ecosystems.
食品生物制造是通过合成生物学技术解决全球营养和可持续性挑战的一种变革性解决方案。工程生物传感器已成为该领域实现智能和多尺度过程监测和质量控制的关键工具。本综述重点介绍了食品合成生物学中最近的生物传感器创新,包括合理设计、技术进步和现实世界的实施框架。在Web of Science数据库中进行了近5年的基础调查,关键词包括“营养物”、“食物”、“生物传感器”和“生物合成”。随后,对检索结果进行筛选,目的是确定有关食品物质的研究。现有的生物传感器利用三种核心转导机制,即细胞生长耦合、光学和电化学,通过加速高通量菌株和酶优化、生物合成途径的动态调节和目标营养物质的敏感定量,促进40多种关键营养物质(如氨基酸、糖和磷脂)的产生。通过动态控制,可使产量提高27倍,检出限低至44.46 pmol/L。未来的食品生物制造将整合人工智能优化、多路复用、智能生物传感器和跨物种平台,重新定义下一代食品生物制造生态系统的精度和可持续性基准。
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引用次数: 0
Recent advances of pretreatments and drying technologies in processing small berries: A comprehensive review 小浆果加工前处理和干燥技术的最新进展综述
IF 15.4 1区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.tifs.2026.105553
Yan Ge , Qiao-Yi Ma , Shan-Yu Wang , Arun S. Mujumdar , Xiaojun Huang , Hong-Wei Xiao , Zi-Liang Liu , Shaoping Nie

Background

Small berries are rich in bioactive compounds and possess high nutritional value, while the high perishability of fresh small berries severely limits their consumptions and utilizations. Drying is an effective preservation strategy that can extend the shelf life and enhance their added values. Notably, the cuticular wax layer of small berries impedes the moisture migration and thus results in serious degradation of bioactive compounds during drying.

Scope and approach

This review systematically describes the criteria of dried small berries and summarizes both conventional and emerging drying technologies, focusing on the dehydration principles, practical applications, and their respective limitations. A critical comparison of these drying techniques is conducted, particularly regarding their effects on the retention of bioactive compounds, physical structure, and sensory properties of dried small berries. In parallel, it analyzes the impact mechanism of various pretreatment techniques on optimizing the drying processes. The performance of various emerging drying technologies in processing small berries is further compared in commercial level. Finally, the optimal strategies for processing small berries are proposed.

Key findings and conclusion

Appropriate pretreatments can disrupt the wax layer structure, enhance cell membrane permeability, and inactivate oxidative enzymes, thereby significantly improving drying efficiency and product quality. Emerging drying technologies combined with environmentally friendly pretreatment not only enables the production of high-quality dried small berries but also enhances the process sustainability through minimized water pollution, reduced carbon emissions, and efficient use of energy resources. However, how to balance the drying efficiency, product quality, and energy consumption during the processing of small berries remains a critical bottleneck. In the future, the integration of artificial intelligence for the real-time control and process optimization is identified as a promising pathway toward efficient, intelligent, and sustainable drying systems of small berries.
小浆果含有丰富的生物活性化合物,具有很高的营养价值,但新鲜小浆果极易腐烂,严重限制了小浆果的食用和利用。干燥是一种有效的保存策略,可以延长保质期,提高其附加值。值得注意的是,小浆果的表皮蜡层阻碍了水分的迁移,从而导致干燥过程中生物活性化合物的严重降解。本文系统地描述了小浆果干燥的标准,总结了传统和新兴的干燥技术,重点介绍了脱水原理、实际应用及其各自的局限性。对这些干燥技术进行了关键的比较,特别是关于它们对干燥的小浆果的生物活性化合物的保留,物理结构和感官特性的影响。同时,分析了各种预处理工艺对优化干燥工艺的影响机理。在商业层面上进一步比较了各种新兴干燥技术在小浆果加工中的性能。最后,提出了小浆果加工的最优策略。结论适当的预处理可以破坏蜡层结构,增强细胞膜通透性,灭活氧化酶,从而显著提高干燥效率和产品质量。新兴的干燥技术与环保预处理相结合,不仅可以生产出高质量的小浆果干燥产品,还可以通过减少水污染、减少碳排放和有效利用能源来提高过程的可持续性。然而,如何在小浆果加工过程中平衡干燥效率、产品质量和能耗仍然是一个关键的瓶颈。在未来,人工智能的实时控制和过程优化的集成被认为是实现高效、智能和可持续的小浆果干燥系统的有希望的途径。
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引用次数: 0
期刊
Trends in Food Science & Technology
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