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From Past to Present: The Journey of Female Doctors in Medicine and Otorhinolaryngology in Turkey. 从过去到现在:土耳其医学和耳鼻喉科女医生的旅程。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-09-01 Epub Date: 2021-10-15 DOI: 10.4274/tao.2021.2021-5-14
Armağan İncesulu, Hülya Eyigör, İlknur Haberal Can, Sema Başak
Patience, diligence, being able to adapt to changing conditions, having good communication skills, being open to innovations, and coping with crises are the almost-innate skills of women. The same features are predictive for success in the field of medicine. However, throughout history, women have been kept away from the field of medicine by claiming that they do not possess the aforementioned features. Further, their prescribed roles were limited to midwives and assistants to male doctors. Although all these, female physicians/surgeons, who have made their mark since ancient times, have existed in Turkey as well as worldwide.
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引用次数: 0
Differentiated Thyroid Carcinoma: Distant Metastasis as an Unusual Sole Initial Manifestation. 分化型甲状腺癌:远端转移是一种罕见的首发表现。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-09-01 Epub Date: 2021-10-15 DOI: 10.4274/tao.2021.2021-2-5
Rahim Dhanani, Muhammad Faisal, Mahir Akram, Osama Shakeel, Muhammad Toqeer Zahid, Aamna Hassan, Raza Hussain

Objective: The objective of this study was to identify the characteristic features of patients with distant metastasis as the only manifestation of well-differentiated thyroid cancers and to analyze the treatment outcomes.

Methods: A retrospective review of all patients with well-differentiated thyroid cancers and distant metastasis as the sole initial presentation was carried out. Data regarding age, gender, tumor histology, site, symptoms, and treatment outcomes were collected.

Results: There were 10 patients who presented with distant metastasis as the only presentation. The mean age was 56.1 years. Eight (80%) patients had osseous metastasis, one (10%) had pulmonary and one (10%) had both. Follicular thyroid carcinoma was more common and seen in six (60%) patients. Seven (77.8%) out of nine patients had demised within five years of initial presentation.

Conclusion: Distant metastases without a neck lump as the initial presentation of well-differentiated thyroid cancers are extremely rare. No specific guidelines are available to manage such patients due to lack of relevant data in the literature.

目的:本研究的目的是确定远端转移是高分化甲状腺癌的唯一表现,并分析其治疗效果。方法:回顾性分析所有以高分化甲状腺癌和远处转移为唯一首发表现的患者。收集有关年龄、性别、肿瘤组织学、部位、症状和治疗结果的数据。结果:10例患者以远处转移为唯一表现。平均年龄为56.1岁。8例(80%)患者有骨转移,1例(10%)有肺转移,1例(10%)两者都有。滤泡性甲状腺癌更为常见,在6例(60%)患者中可见。9例患者中有7例(77.8%)在首次就诊后5年内死亡。结论:未出现颈部肿块的远端转移作为高分化甲状腺癌的初始表现是极为罕见的。由于文献中缺乏相关数据,目前尚无具体的指导方针来管理此类患者。
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引用次数: 1
Evaluation of Speech Recognition Skills in Different Noises with the Turkish Matrix Sentence Test in Hearing Aid Users. 助听器使用者土耳其语矩阵句测试对不同噪声下语音识别技能的评估。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-06-01 Epub Date: 2021-07-30 DOI: 10.4274/tao.2021.6179
Bünyamin Çıldır, Suna Tokgöz-Yılmaz

Objective: This study aimed to analyze the effectiveness of the Turkish matrix sentence test in evaluating the speech recognition performance of hearing aid users under different noise conditions.

Methods: Speech recognition performance of 42 individuals, 20 to 65 years of age (mean 49.1±14 years) with bilateral sensorineural hearing loss was measured in noise with the Turkish matrix sentence test without a background noise and with headphones. Additionally, the participants' speech recognition thresholds were measured with a matrix test while wearing their hearing aid under three different listening conditions in which the phases of speech and noise stimuli were changed with constant and fluctuating noise.

Results: Speech-recognition thresholds were better in fluctuating noise than in constant noise in all listening conditions, and this difference was statistically significant (p=0.02). In both types of noise, speech-recognition thresholds of bilateral hearing aid users (n=29) were lower (better) than those of unilateral hearing aid users (n=13) under three different listening conditions, but there was no statistically significant difference (p=0.67). Speech-recognition thresholds without hearing aids were statistically higher (worse) than those obtained with hearing aids (p=0.001).

Conclusion: Since the Turkish matrix sentence test gives useful results, this test can be used in the diagnosis, follow-up, and rehabilitation planning of hearing aid users. We observed that speech intelligibility was better, although there were differences among those with hearing loss when the speech test was conducted in fluctuating background noise with the Turkish matrix sentence test.

目的:本研究旨在分析土耳其矩阵句测试在不同噪声条件下评估助听器使用者语音识别性能的有效性。方法:对42例20 ~ 65岁(平均49.1±14岁)双侧感音神经性听力损失患者,在无背景噪声和戴耳机的情况下,采用土耳其矩阵句测试法测量其语音识别能力。此外,参与者戴着助听器,在三种不同的听力条件下,通过矩阵测试测量语音识别阈值,在三种不同的听力条件下,语音和噪音刺激的相位随恒定和波动的噪音而变化。结果:在所有听力条件下,波动噪声下的语音识别阈值优于恒定噪声下的语音识别阈值,差异有统计学意义(p=0.02)。在两种噪声下,三种不同听力条件下,双侧助听器使用者(n=29)的语音识别阈值均低于(优于)单侧助听器使用者(n=13),但差异无统计学意义(p=0.67)。未使用助听器的语音识别阈值比使用助听器的语音识别阈值高(差)(p=0.001)。结论:由于土耳其矩阵句测试结果有用,该测试可用于助听器使用者的诊断、随访和康复计划。我们观察到,虽然在波动背景噪声中使用土耳其矩阵句测试进行语音测试时,听力损失者的语音清晰度存在差异,但语音清晰度更好。
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引用次数: 0
Symptomatic Solid Ectopic Cervical Thymus in a 2-Month-Old Infant: Case Report. 2个月婴儿症状性实性宫颈胸腺异位1例。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-06-01 Epub Date: 2021-07-30 DOI: 10.4274/tao.2021.2021-2-16
Nursultan Abakir, Fakih Cihat Eravcı, Ganime Dilek Emlik

Ectopic cervical thymus (ECT) is a rare pediatric pathology usually with an asymptomatic course. In fewer cases, the patient may present with dyspnea, hoarseness, stridor, dysphagia and pain. The mass may present in cystic or solid forms. Solid forms are rare, constituting only 10% of all ECT cases and these are mostly symptomatic. We aimed to present the case of an infant with ECT in the submandibular region that led to shortness of breath. ECTs in the submandibular region are mostly solid and larger in size, and therefore, likely to result in compressive symptoms. In this case report, we tried to cover the important aspects of the diagnosis of ECT, its treatment, and discussed the results with a literature review. We additionally aimed to emphasize the importance of considering pediatric ECT in the differential diagnosis of pediatric neck mass as well as considering surgical excision to prevent serious consequences.

宫颈胸腺异位(ECT)是一种罕见的儿科病理,通常无症状。在少数病例中,患者可能出现呼吸困难、声音嘶哑、喘鸣、吞咽困难和疼痛。肿块可呈囊状或实状。实性形式很少见,仅占所有ECT病例的10%,而且大多是有症状的。我们的目的是提出一个病例的婴儿与电痉挛在下颌区域,导致呼吸短促。下颌下区域的ect多为实心且体积较大,因此可能导致压迫症状。在本病例报告中,我们试图涵盖ECT诊断和治疗的重要方面,并通过文献综述讨论结果。此外,我们旨在强调小儿ECT在小儿颈部肿块鉴别诊断中的重要性,以及考虑手术切除以防止严重后果。
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引用次数: 1
Allergy Practices in Otorhinolaryngology Residency Programs in Turkey: Quo Vadis? 土耳其耳鼻喉科住院医师项目的过敏实践:现状?
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-06-01 Epub Date: 2021-07-30 DOI: 10.4274/tao.2021.6160
Erdem Mengi, Cüneyt Orhan Kara, Bülent Topuz

Objective: The aim of this study was to investigate how allergy practices in the otorhinolaryngology (ORL) residency departments in Turkey have changed over the last 20 years and to examine the current status in ORL residency training.

Methods: A 17-item questionnaire was developed following the study goals by a team experienced in allergy practices. The questionnaire was sent via e-mail to the program directors of all the 95 ORL residency departments in Turkey.

Results: A total of 60 (63.2%) program directors completed the questionnaire. We found that allergy testing and immunotherapy had been performed in 70% and 28.3%, respectively, at any time to date. The most common reason for discontinuing in allergy practices over time was "the changes introduced by the Turkish Social Security Institute as stated in the healthcare implementation communiqué" and "the difficulties in obtaining vaccine supplies from companies". Of all departments, allergy testing, immunotherapy, nasal smear, and nasal provocation tests were performed only by 35%, 8.3%, 28.3%, and 1.7%, respectively.

Conclusion: Allergy practices have been increasingly used, especially in the 2000s, but came to a standstill upon the changes introduced by the Turkish Social Security Institute as stated in the healthcare implementation communiqué. These findings suggest that allergy training, in the recent years, has remained in the background in ORL residency programs in Turkey. To achieve standardization in allergy training in ORL residency programs, professional associations and authorities should develop solutions in cooperation with legislators.

目的:本研究的目的是调查土耳其耳鼻喉科(ORL)住院医师部门的过敏实践在过去20年中发生了怎样的变化,并检查ORL住院医师培训的现状。方法:一个有过敏实践经验的团队根据研究目标制定了一份17项的调查问卷。问卷通过电子邮件发送给土耳其所有95个ORL住院医师部门的项目主管。结果:共60名项目主任(63.2%)完成了问卷调查。我们发现,到目前为止,分别有70%和28.3%的患者在任何时候进行了过敏试验和免疫治疗。随着时间的推移,停止过敏治疗的最常见原因是"土耳其社会安全研究所在医疗保健实施公报中提出的变化"和"从公司获得疫苗供应的困难"。在所有科室中,过敏试验、免疫治疗、鼻涂片和鼻激发试验分别仅占35%、8.3%、28.3%和1.7%。结论:过敏实践越来越多地使用,特别是在2000年代,但在医疗保健实施公报中指出,土耳其社会安全研究所引入的变化使其停滞不前。这些发现表明,近年来,过敏训练在土耳其的ORL住院医师项目中一直处于背景地位。为了实现ORL住院医师项目过敏培训的标准化,专业协会和当局应与立法者合作制定解决方案。
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引用次数: 0
Radiological Features and Pathognomonic Sign of Stapes Footplate Fistula in Inner Ear Malformations. 内耳畸形镫骨足板瘘的影像学特征及病理征象。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-06-01 Epub Date: 2021-07-30 DOI: 10.4274/tao.2021.6180
Levent Sennaroğlu

Objective: Some inner ear malformations may cause recurrent meningitis, which may be fatal. The etiology is usually a stapes footplate fistula which enables microorganisms to pass into the inner ear containing cerebrospinal fluid (CSF), causing repeated attacks of meningitis. Radiological signs of the fistula are not obvious and are not reported in detail in the literature. The aim of the study is to investigate the radiological features of stapes footplate fistula in inner ear malformations.

Methods: Radiological findings were analyzed for seventeen patients with inner ear malformations (IEMs) operated on because of recurrent meningitis. Using this information, images of 1,010 patients with IEMs were retrospectively reviewed to investigate the radiological findings of stapes footplate fistula and their relationship to IEMs. They were classified according to the Sennaroglu classification system, and according to different stages of stapes footplate fistula.

Results: In the case of a stapes footplate cyst, computerized tomography shows an opacity at the oval window. On magnetic resonance imaging, a fluid filled cystic structure continuous with and having similar signal characteristics to the CSF in the inner ear is a pathognomonic finding of a stapes footplate cyst. It is most commonly found in common cavity anomaly (18.2%); the second most frequent finding is incomplete partition type I (15%). And it can even be seen in cases of cochlear aplasia where only the vestibule is present.

Conclusion: If the history reveals recurrent meningitis, particular attention should be given to the oval window area, where an opacity, cyst or a leaking lesion should be looked for on the imaging. It is the responsibility of the otolaryngologist to notice these findings, and to operate on the patient to prevent further attacks of meningitis.

目的:某些内耳畸形可引起复发性脑膜炎,并可致命。病因通常是镫骨足板瘘,使微生物进入含有脑脊液(CSF)的内耳,导致脑膜炎反复发作。瘘的放射学征象不明显,在文献中没有详细报道。本研究的目的是探讨镫骨足板瘘在内耳畸形中的影像学表现。方法:对17例因复发性脑膜炎而行内耳畸形手术的患者的影像学表现进行分析。利用这些信息,我们回顾性分析了1010例IEMs患者的图像,以研究镫骨足板瘘的影像学表现及其与IEMs的关系。根据Sennaroglu分类系统和镫骨足部瘘的不同阶段进行分类。结果:镫骨足底囊肿病例,计算机断层扫描显示卵圆窗处可见混浊。在磁共振成像上,一个与内耳脑脊液连续且信号特征相似的充满液体的囊性结构是镫骨足底囊肿的典型病理表现。最常见于普通腔异常(18.2%);第二个最常见的发现是I型不完整分区(15%)。甚至可以在耳蜗发育不全的病例中看到只有前庭存在。结论:如果病史显示复发性脑膜炎,应特别注意卵圆窗区,在影像学上应注意有无混浊、囊肿或渗漏性病变。耳鼻喉科医生有责任注意到这些发现,并对患者进行手术以防止脑膜炎的进一步发作。
{"title":"Radiological Features and Pathognomonic Sign of Stapes Footplate Fistula in Inner Ear Malformations.","authors":"Levent Sennaroğlu","doi":"10.4274/tao.2021.6180","DOIUrl":"https://doi.org/10.4274/tao.2021.6180","url":null,"abstract":"<p><strong>Objective: </strong>Some inner ear malformations may cause recurrent meningitis, which may be fatal. The etiology is usually a stapes footplate fistula which enables microorganisms to pass into the inner ear containing cerebrospinal fluid (CSF), causing repeated attacks of meningitis. Radiological signs of the fistula are not obvious and are not reported in detail in the literature. The aim of the study is to investigate the radiological features of stapes footplate fistula in inner ear malformations.</p><p><strong>Methods: </strong>Radiological findings were analyzed for seventeen patients with inner ear malformations (IEMs) operated on because of recurrent meningitis. Using this information, images of 1,010 patients with IEMs were retrospectively reviewed to investigate the radiological findings of stapes footplate fistula and their relationship to IEMs. They were classified according to the Sennaroglu classification system, and according to different stages of stapes footplate fistula.</p><p><strong>Results: </strong>In the case of a stapes footplate cyst, computerized tomography shows an opacity at the oval window. On magnetic resonance imaging, a fluid filled cystic structure continuous with and having similar signal characteristics to the CSF in the inner ear is a pathognomonic finding of a stapes footplate cyst. It is most commonly found in common cavity anomaly (18.2%); the second most frequent finding is incomplete partition type I (15%). And it can even be seen in cases of cochlear aplasia where only the vestibule is present.</p><p><strong>Conclusion: </strong>If the history reveals recurrent meningitis, particular attention should be given to the oval window area, where an opacity, cyst or a leaking lesion should be looked for on the imaging. It is the responsibility of the otolaryngologist to notice these findings, and to operate on the patient to prevent further attacks of meningitis.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"59 2","pages":"95-102"},"PeriodicalIF":0.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/36/tao-59-95.PMC8329392.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39307025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Giant Epignathus (Teratoma of Palatine Tonsil): A Case Report. 巨大表腺瘤(腭扁桃体畸胎瘤)1例报告。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-06-01 Epub Date: 2021-07-30 DOI: 10.4274/tao.2021.2021-4-7
Fuat Aydemir, Mert Mutaf, Mehmet Akif Eryılmaz

Teratomas are benign tumours containing tissues derived from ectoderm, endoderm and mesoderm Epignathus is a rare congenital teratoma and originates from oropharyngeal region. We present a case of giant epignathus arising from tonsillar region in a neonate. A male neonate that was born with a 38-week cesarean section presented with a pedunculated mass from left tonsilla palatina and protruding outside the mouth. The patient did not have any airway problem. Magnetic resonance imaging and computed tomography scan showed no intracranial extension. The patient was operated on the postpartum 3rd day and the mass was excised successfully. After histopathological examination, mature teratoma was diagnosed. During post-operative 6 months control visit, there was no recurrence. Epignathus is a rare congenital oropharyngeal teratoma, it should be diagnosed in the fetus as early as possible. Teratomas of the tonsilla palatina are extremely rare. In such cases, the mass may cause airway obstruction and feeding difficulties so complete resection is curative in most cases during the early neonatal period.

畸胎瘤是一种良性肿瘤,包含来自外胚层、内胚层和中胚层的组织,表ignathus是一种罕见的先天性畸胎瘤,起源于口咽区。我们提出了一个巨大的表腺从扁桃体区域产生的新生儿的情况。男性新生儿经38周剖宫产出生,左侧腭扁桃体有带蒂肿块,突出于口腔外。病人没有呼吸道问题。核磁共振及电脑断层扫描未见颅内扩张。患者于产后第3天手术,成功切除肿块。经组织病理学检查,诊断为成熟畸胎瘤。术后6个月对照随访,无复发。表腺赘是一种罕见的先天性口咽畸胎瘤,在胎儿时应尽早诊断。腭扁桃体畸胎瘤极为罕见。在这种情况下,肿块可能引起气道阻塞和喂养困难,因此在大多数情况下,在新生儿早期完全切除是可以治愈的。
{"title":"Giant Epignathus (Teratoma of Palatine Tonsil): A Case Report.","authors":"Fuat Aydemir,&nbsp;Mert Mutaf,&nbsp;Mehmet Akif Eryılmaz","doi":"10.4274/tao.2021.2021-4-7","DOIUrl":"https://doi.org/10.4274/tao.2021.2021-4-7","url":null,"abstract":"<p><p>Teratomas are benign tumours containing tissues derived from ectoderm, endoderm and mesoderm Epignathus is a rare congenital teratoma and originates from oropharyngeal region. We present a case of giant epignathus arising from tonsillar region in a neonate. A male neonate that was born with a 38-week cesarean section presented with a pedunculated mass from left tonsilla palatina and protruding outside the mouth. The patient did not have any airway problem. Magnetic resonance imaging and computed tomography scan showed no intracranial extension. The patient was operated on the postpartum 3rd day and the mass was excised successfully. After histopathological examination, mature teratoma was diagnosed. During post-operative 6 months control visit, there was no recurrence. Epignathus is a rare congenital oropharyngeal teratoma, it should be diagnosed in the fetus as early as possible. Teratomas of the tonsilla palatina are extremely rare. In such cases, the mass may cause airway obstruction and feeding difficulties so complete resection is curative in most cases during the early neonatal period.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"59 2","pages":"158-161"},"PeriodicalIF":0.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/72/tao-59-158.PMC8329394.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39306938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of Korean Red Ginseng on Noise-Induced Hearing Loss. 红参对噪声性听力损失的影响。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-06-01 Epub Date: 2021-07-30 DOI: 10.4274/tao.2021.2021-1-5
Serpil Mungan Durankaya, Yüksel Olgun, Safiye Aktaş, Hande Evin Eskicioğlu, Selhan Gürkan, Zekiye Altun, Başak Mutlu, Efsun Kolatan, Ersoy Doğan, Osman Yılmaz, Günay Kırkım

Objective: Noise-induced hearing loss (NIHL) is one of the most important problems affecting both social and professional life of patients. There is no treatment method considered to be successful on the hearing loss that has become a permanent nature. Aim of this study is to evaluate protective effect of Korean Red Ginseng (KRG) against NIHL in an animal model.

Methods: Twenty-eight rats were separated into four groups [control saline (group I), control KRG (group II), saline + noise (group III), KRG + noise (group IV)]. Rats in the saline and KRG groups were fed via oral gavage with a dose of 200 mg/kg/day throughout for 10 days. Fourteen rats (group III and IV) were exposed to 4 kHz octave band noise at 120 dB SPL for 5 hours. Hearing levels of rats were evaluated by distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR) at 4, 8, 12, 16 and 32 kHz frequencies prior to and on days 1, 7 and 10 after the noise exposure. Rats were sacrificed on 10th day, after the last audiological test. Cochlea and spiral ganglion tissues were evaluated by light microscopy.

Results: Audiological and histological results demonstrated that after noise the group IV showed better results than group III. In the noise exposed groups, the most prominent damage was seen at the 8 kHz frequency region than other regions. After the noise exposure, DPOAE responses were lost in 1st, 7th and 10th measurements in both group III and IV. Thus, we were not able to perform any statistical analyses for DPOAE results.

Conclusion: Our findings suggest that KRG seems to be an efficient agent against NIHL. There is need for additional research to find out about the mechanisms of KRG's protective effect.

目的:噪声性听力损失(NIHL)是影响患者社会生活和职业生活的重要问题之一。对于已经成为永久性的听力损失,没有一种治疗方法被认为是成功的。本研究的目的是在动物模型上评价红参对NIHL的保护作用。方法:将28只大鼠分为4组[对照生理盐水组(I组)、对照KRG组(II组)、生理盐水+噪声组(III组)、KRG +噪声组(IV组)]。生理盐水组和KRG组大鼠灌胃,剂量为200 mg/kg/d,连续10 d。将14只大鼠(III组和IV组)置于120 dB声压级4 kHz频带噪声下5小时。在噪声暴露前和暴露后第1、7和10天,采用4、8、12、16和32 kHz频率下的畸变产物耳声发射(DPOAE)和听觉脑干反应(ABR)来评估大鼠的听力水平。最后一次听力学试验结束后第10天处死大鼠。光镜下观察耳蜗和螺旋神经节组织。结果:听力学和组织学结果显示,经噪声处理后,IV组优于III组。在噪声暴露组中,8 kHz频率区域的损伤最为明显。噪声暴露后,III组和IV组的DPOAE响应在第1、7和10次测量中都消失了。因此,我们无法对DPOAE结果进行任何统计分析。结论:KRG可能是一种有效的抗NIHL药物。KRG的保护作用机制有待进一步研究。
{"title":"Effect of Korean Red Ginseng on Noise-Induced Hearing Loss.","authors":"Serpil Mungan Durankaya,&nbsp;Yüksel Olgun,&nbsp;Safiye Aktaş,&nbsp;Hande Evin Eskicioğlu,&nbsp;Selhan Gürkan,&nbsp;Zekiye Altun,&nbsp;Başak Mutlu,&nbsp;Efsun Kolatan,&nbsp;Ersoy Doğan,&nbsp;Osman Yılmaz,&nbsp;Günay Kırkım","doi":"10.4274/tao.2021.2021-1-5","DOIUrl":"https://doi.org/10.4274/tao.2021.2021-1-5","url":null,"abstract":"<p><strong>Objective: </strong>Noise-induced hearing loss (NIHL) is one of the most important problems affecting both social and professional life of patients. There is no treatment method considered to be successful on the hearing loss that has become a permanent nature. Aim of this study is to evaluate protective effect of Korean Red Ginseng (KRG) against NIHL in an animal model.</p><p><strong>Methods: </strong>Twenty-eight rats were separated into four groups [control saline (group I), control KRG (group II), saline + noise (group III), KRG + noise (group IV)]. Rats in the saline and KRG groups were fed via oral gavage with a dose of 200 mg/kg/day throughout for 10 days. Fourteen rats (group III and IV) were exposed to 4 kHz octave band noise at 120 dB SPL for 5 hours. Hearing levels of rats were evaluated by distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR) at 4, 8, 12, 16 and 32 kHz frequencies prior to and on days 1, 7 and 10 after the noise exposure. Rats were sacrificed on 10th day, after the last audiological test. Cochlea and spiral ganglion tissues were evaluated by light microscopy.</p><p><strong>Results: </strong>Audiological and histological results demonstrated that after noise the group IV showed better results than group III. In the noise exposed groups, the most prominent damage was seen at the 8 kHz frequency region than other regions. After the noise exposure, DPOAE responses were lost in 1st, 7th and 10th measurements in both group III and IV. Thus, we were not able to perform any statistical analyses for DPOAE results.</p><p><strong>Conclusion: </strong>Our findings suggest that KRG seems to be an efficient agent against NIHL. There is need for additional research to find out about the mechanisms of KRG's protective effect.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"59 2","pages":"111-117"},"PeriodicalIF":0.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/bb/tao-59-111.PMC8329393.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39306931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model. 丁香酚对实验性大鼠心肌硬化的短期预防作用。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-06-01 Epub Date: 2021-07-30 DOI: 10.4274/tao.2021.6196
Oğuz Kadir Eğilmez, Mehmet Güven, Sena Genç Elden, Özcan Budak, Hüseyin Çakıroğlu, Halil Elden, Ebru Mihriban Güven

Objective: The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).

Methods: Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol.

Results: In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p<0.05). Fibrosis and inflammation regarding the lamina propria (LP) of the eardrums of the topical and oral eugenol groups were significantly less than those of the control and saline groups (p<0.001). In microscopic evaluation, TMs were found to be thicker in the control and saline groups (p<0.001).

Conclusion: Our study showed that the application of topical and oral forms of eugenol reduced fibrosis and prevented the advancement of MS in the LP of the TMs in the short-term. More studies with different extracts are needed to investigate the efficacy of phytotherapeutic agents for preventing MS development following myringotomy.

目的:本研究的目的是评估外用和口服丁香酚对实验性myringosclerosis (MS)的短期抑制作用。方法:采用雄性Wistar白化大鼠4组,7只。所有受试者均行鼓膜切除术,1组不给予任何治疗(作为对照组),2组给予生理盐水治疗,3组给予外用丁香酚治疗,4组给予口服丁香酚治疗。结果:宏观评价中,对照组和生理盐水组的MS明显高于外用和口服丁香酚组,而外用和口服丁香酚组的MS变化具有统计学意义(p)。结论:我们的研究表明,外用和口服丁香酚可在短期内减轻TMs的纤维化,并阻止MS在LP中的进展。不同提取物对植物治疗药物预防鼓膜切开术后多发性硬化症的疗效有待进一步研究。
{"title":"The Short-Term Effect of Eugenol on the Prevention of Experimentally Induced Myringosclerosis in a Rat Model.","authors":"Oğuz Kadir Eğilmez,&nbsp;Mehmet Güven,&nbsp;Sena Genç Elden,&nbsp;Özcan Budak,&nbsp;Hüseyin Çakıroğlu,&nbsp;Halil Elden,&nbsp;Ebru Mihriban Güven","doi":"10.4274/tao.2021.6196","DOIUrl":"https://doi.org/10.4274/tao.2021.6196","url":null,"abstract":"<p><strong>Objective: </strong>The aim of our study was to assess the possible short-term effects of topical and oral eugenol on the suppression of experimentally developed myringosclerosis (MS).</p><p><strong>Methods: </strong>Four groups of seven male Wistar albino rats were used in the study. The tympanic membranes (TMs) of all subjects were myringotomized, and group 1 was given no treatment (as control group), group 2 received saline, group 3 had received topical eugenol and group 4 received oral eugenol.</p><p><strong>Results: </strong>In macroscopic evaluation the control and saline groups showed much more MS compared to the topical and oral eugenol groups which had statistically significantly less changes (p<0.05). Fibrosis and inflammation regarding the lamina propria (LP) of the eardrums of the topical and oral eugenol groups were significantly less than those of the control and saline groups (p<0.001). In microscopic evaluation, TMs were found to be thicker in the control and saline groups (p<0.001).</p><p><strong>Conclusion: </strong>Our study showed that the application of topical and oral forms of eugenol reduced fibrosis and prevented the advancement of MS in the LP of the TMs in the short-term. More studies with different extracts are needed to investigate the efficacy of phytotherapeutic agents for preventing MS development following myringotomy.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"59 2","pages":"124-132"},"PeriodicalIF":0.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/82/tao-59-124.PMC8329402.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39306934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Vestibular Illusions and Alterations in Aerospace Environment. 航天环境下的前庭幻觉与变化。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2021-06-01 Epub Date: 2021-07-30 DOI: 10.4274/tao.2021.2021-3-3
Abdurrahman Engin Demir, Erdinç Aydın

As the aerospace industry has grown rapidly over the years, aviators and astronauts have been exposed to some abnormal physiological changes arising from the dynamics of the aerospace environment. The vestibular system, encoding linear and angular movements of the head, is one of the main affected systems in which those abnormal changes can occur during flight. Despite the intricate and solid organization, vestibular units are such delicate structures that they can easily be deceived by aerial dynamics and gravity changes. Therefore, it is of vital importance for the continuity of flight safety to be aware of the detrimental alterations and impairments regarding the vestibular system and its reflex pathways. The aim of this paper was to present a review about how a healthy vestibular system is negatively affected within the aerospace environment and how some vestibular disorders become exaggerated or impaired during aviation and space activities.

近年来,随着航空航天事业的迅速发展,航空航天环境的动态变化使飞行员和航天员面临着一些异常的生理变化。前庭系统编码头部的线性和角度运动,是飞行过程中发生这些异常变化的主要受影响系统之一。尽管前庭单元的结构复杂而坚固,但它们是如此微妙的结构,很容易被空气动力学和重力变化所欺骗。因此,了解前庭系统及其反射通路的有害改变和损伤对飞行安全的连续性至关重要。本文的目的是介绍健康的前庭系统是如何在航空航天环境中受到负面影响的,以及一些前庭疾病是如何在航空航天活动中被夸大或损害的。
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引用次数: 4
期刊
Turkish Archives of Otorhinolaryngology
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