Pub Date : 2023-03-01DOI: 10.4274/tao.2023.2022-11-6
Abdullah Dalğıç, Gökçe Aksoy Yıldırım, Mehmet Ekrem Zorlu, Orçun Delice, Abdulhalim Aysel
Objective: This study aimed to evaluate the outcomes of total transcanal endoscopic cholesteatoma surgery.
Methods: Twenty-seven cholesteatoma patients that had undergone transcanal endoscopic ear surgery (TEES) were included in the study. Age, sex, operation date of patients, operated side, need for ossiculoplasty, graft material, and surgical technique were recorded. All patients were evaluated through otoscopic, endoscopic, and audiological examinations and followed up for at least five months after surgery. All patients were staged using the European Academy of Otology and Neurotology/Japan Otological Society (EAONO/JOS) Staging System on Middle Ear Cholesteatoma.
Results: Mean age of the patients was 36.4 years (range, 4-67 years). According to the EAONO/JOS Staging System, 11 patients were stage 1, while 11 were stage 2, and five were stage 3. Two had lateral semicircular canal defect, one had facial canal dehiscence, and one had oval window defect. The average follow-up period was 19 months (range, 5-41 months), during which two patients experienced retraction pocket and hearing loss and one patient had perforation. One patient underwent revision surgery during follow-up and no recurrence or residual cholesteatoma was observed. The preoperative and postoperative air-bone gaps were 25.14±13.93 dB and 22.22±12.64 dB with no significant difference.
Conclusion: TEES is a minimally invasive and safe procedure with low complication and recurrence rates. As with all surgical procedures, experience is essential, and as experience increases, the capability to perform endoscopic otologic surgery on more complex cases may become possible.
{"title":"Total Transcanal Endoscopic Ear Surgery for Cholesteatoma.","authors":"Abdullah Dalğıç, Gökçe Aksoy Yıldırım, Mehmet Ekrem Zorlu, Orçun Delice, Abdulhalim Aysel","doi":"10.4274/tao.2023.2022-11-6","DOIUrl":"https://doi.org/10.4274/tao.2023.2022-11-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the outcomes of total transcanal endoscopic cholesteatoma surgery.</p><p><strong>Methods: </strong>Twenty-seven cholesteatoma patients that had undergone transcanal endoscopic ear surgery (TEES) were included in the study. Age, sex, operation date of patients, operated side, need for ossiculoplasty, graft material, and surgical technique were recorded. All patients were evaluated through otoscopic, endoscopic, and audiological examinations and followed up for at least five months after surgery. All patients were staged using the European Academy of Otology and Neurotology/Japan Otological Society (EAONO/JOS) Staging System on Middle Ear Cholesteatoma.</p><p><strong>Results: </strong>Mean age of the patients was 36.4 years (range, 4-67 years). According to the EAONO/JOS Staging System, 11 patients were stage 1, while 11 were stage 2, and five were stage 3. Two had lateral semicircular canal defect, one had facial canal dehiscence, and one had oval window defect. The average follow-up period was 19 months (range, 5-41 months), during which two patients experienced retraction pocket and hearing loss and one patient had perforation. One patient underwent revision surgery during follow-up and no recurrence or residual cholesteatoma was observed. The preoperative and postoperative air-bone gaps were 25.14±13.93 dB and 22.22±12.64 dB with no significant difference.</p><p><strong>Conclusion: </strong>TEES is a minimally invasive and safe procedure with low complication and recurrence rates. As with all surgical procedures, experience is essential, and as experience increases, the capability to perform endoscopic otologic surgery on more complex cases may become possible.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/a7/tao-61-1.PMC10424586.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10388761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.4274/tao.2023.2023-1-6
Güliz Akın Öztürk, Gizem Ermiş, Emre Eskicioğlu, Çağdaş Güdücü
Olfaction is critical for maintaining daily life activities. It is crucial to measure olfactory performance for the diagnosis and treatment of certain neurodegenerative diseases. Moreover, impairments and a lack of quality in the olfactory system may indicate the early diagnosis of some diseases such as Parkinson's. In this context, there are several imaging methods available for evaluating olfactory function. In addition to the conventional methods used in measuring the brain's responsiveness to olfactory stimuli, this article presents a systematic review of the current applicability of optical brain imaging (i.e., functional near-infrared spectroscopy) in the evaluation of olfactory function. A database literature search was conducted in PubMed, Scopus, the Web of Science, and ScienceDirect. This review excluded animal studies, clinical studies, pathology- or neurodegenerative disease-related studies, newborn-related studies, cross-modal- and dual-task-related studies, and non-original research studies. Thus, seven studies were examined to discuss the pitfalls and perspectives of the use of optical brain imaging under olfactory stimulation. As for this conclusion, they can be used to evaluate olfactory performance in healthy individuals through the interpretation of hemodynamic changes. Further studies are needed to standardize the applicability of these optical imaging techniques.
嗅觉对于维持日常生活活动至关重要。测量嗅觉性能对于某些神经退行性疾病的诊断和治疗至关重要。此外,嗅觉系统的损伤和质量的缺乏可能预示着一些疾病的早期诊断,比如帕金森氏症。在这种情况下,有几种成像方法可用于评估嗅觉功能。除了测量大脑对嗅觉刺激的反应性的传统方法外,本文还系统地回顾了目前光学脑成像(即功能近红外光谱)在嗅觉功能评估中的适用性。在PubMed、Scopus、Web of Science和ScienceDirect中进行了数据库文献检索。本综述排除了动物研究、临床研究、病理或神经退行性疾病相关研究、新生儿相关研究、跨模式和双任务相关研究以及非原创性研究。因此,我们对七项研究进行了检查,以讨论嗅觉刺激下使用光学脑成像的缺陷和前景。根据这一结论,它们可以通过解释血液动力学变化来评估健康个体的嗅觉表现。为了规范这些光学成像技术的适用性,需要进一步的研究。
{"title":"The Pitfalls and Perspectives of Assessing Olfactory Function via Optical Brain Imaging.","authors":"Güliz Akın Öztürk, Gizem Ermiş, Emre Eskicioğlu, Çağdaş Güdücü","doi":"10.4274/tao.2023.2023-1-6","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-1-6","url":null,"abstract":"<p><p>Olfaction is critical for maintaining daily life activities. It is crucial to measure olfactory performance for the diagnosis and treatment of certain neurodegenerative diseases. Moreover, impairments and a lack of quality in the olfactory system may indicate the early diagnosis of some diseases such as Parkinson's. In this context, there are several imaging methods available for evaluating olfactory function. In addition to the conventional methods used in measuring the brain's responsiveness to olfactory stimuli, this article presents a systematic review of the current applicability of optical brain imaging (i.e., functional near-infrared spectroscopy) in the evaluation of olfactory function. A database literature search was conducted in PubMed, Scopus, the Web of Science, and ScienceDirect. This review excluded animal studies, clinical studies, pathology- or neurodegenerative disease-related studies, newborn-related studies, cross-modal- and dual-task-related studies, and non-original research studies. Thus, seven studies were examined to discuss the pitfalls and perspectives of the use of optical brain imaging under olfactory stimulation. As for this conclusion, they can be used to evaluate olfactory performance in healthy individuals through the interpretation of hemodynamic changes. Further studies are needed to standardize the applicability of these optical imaging techniques.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/ab/tao-61-37.PMC10424587.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10366922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.4274/tao.2023.2023-4-1
Mehmet Emre Sivrice, Vural Akın, Bekir Büyükçelik, Hasan Yasan, Mehmet Kıran, Veysel Atilla Ayyıldız
Atypical lipomatous tumor, also known as well-differentiated liposarcoma, is rare in the head and neck region. The primary and most effective option in the treatment of this malignancy with a good prognosis is excision with clean surgical margins. Therefore, it is important to distinguish this malignancy from lesions that require more aggressive treatment. In this article, we present the case of an atypical lipomatous tumor originating from the nasopharynx and almost completely obstructing the oropharynx in a 38-year-old male patient with chronic lymphocytic leukemia. To the best of our knowledge, this is the first report in the literature of an atypical lipomatous tumor case originating from the nasopharynx.
{"title":"Atypical Lipomatous Tumor Originating From the Nasopharynx in a Patient with Chronic Lymphocytic Leukemia.","authors":"Mehmet Emre Sivrice, Vural Akın, Bekir Büyükçelik, Hasan Yasan, Mehmet Kıran, Veysel Atilla Ayyıldız","doi":"10.4274/tao.2023.2023-4-1","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-4-1","url":null,"abstract":"<p><p>Atypical lipomatous tumor, also known as well-differentiated liposarcoma, is rare in the head and neck region. The primary and most effective option in the treatment of this malignancy with a good prognosis is excision with clean surgical margins. Therefore, it is important to distinguish this malignancy from lesions that require more aggressive treatment. In this article, we present the case of an atypical lipomatous tumor originating from the nasopharynx and almost completely obstructing the oropharynx in a 38-year-old male patient with chronic lymphocytic leukemia. To the best of our knowledge, this is the first report in the literature of an atypical lipomatous tumor case originating from the nasopharynx.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/43/tao-61-47.PMC10424584.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10388763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.4274/tao.2023.2023-1-8
Vural Akın, Mehmet Emre Sivrice, Veysel Atilla Ayyıldız, Mehmet Kıran
Sialolithiasis is the primary cause of swelling in the major salivary glands. The etiopathogenesis is not clear. Adenoid cystic carcinoma is a slow-growing salivary gland malignancy with a poor prognosis. There are only a few cases in the literature reporting the coexistence of sialolithiasis and adenoid cystic carcinoma. In this report, we present a case that was thought to have sialolithiasis in the foreground because of the calcified image on computed tomography, but was diagnosed with adenoid cystic carcinoma after excision, together with a discussion of the relationship between sialolithiasis and carcinogenesis.
{"title":"Coexistence of Adenoid Cystic Carcinoma and Sialolithiasis in Submandibular Gland: Case Report.","authors":"Vural Akın, Mehmet Emre Sivrice, Veysel Atilla Ayyıldız, Mehmet Kıran","doi":"10.4274/tao.2023.2023-1-8","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-1-8","url":null,"abstract":"<p><p>Sialolithiasis is the primary cause of swelling in the major salivary glands. The etiopathogenesis is not clear. Adenoid cystic carcinoma is a slow-growing salivary gland malignancy with a poor prognosis. There are only a few cases in the literature reporting the coexistence of sialolithiasis and adenoid cystic carcinoma. In this report, we present a case that was thought to have sialolithiasis in the foreground because of the calcified image on computed tomography, but was diagnosed with adenoid cystic carcinoma after excision, together with a discussion of the relationship between sialolithiasis and carcinogenesis.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/14/tao-61-43.PMC10424580.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10388760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.4274/tao.2023.2022-12-1
Mehmet Akif Alan, Hilal Yücel
Objective: The study was designed to evaluate the effectiveness of the asymmetric dorsal preservation technique for correcting I-shaped crooked nose deformity (CND).
Methods: Patients with I-shaped CND who underwent asymmetric dorsal preservation in the period from September 2020 to September 2021 were included in this retrospective study. The Rhinomanometry and Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) was used to assess the outcomes. Deviation angle (DA) measurements were used to evaluate the degree of crookedness. The results were recorded both preoperatively and 12 months postoperatively.
Results: Twenty-three patients were included in the study. Total nasal airflow and long-side nasal airflow were significantly higher 12 months postoperatively (p=0.001 each). Total nasal resistance, long-side nasal resistance, SCHNOS scores and DA measurements were significantly lower 12 months postoperatively (p<0.001 each).
Conclusion: Asymmetric dorsal preservation is a successful alternative technique for correcting I-shaped CND and achieving optimal aesthetic and functional outcomes.
{"title":"Functional and Aesthetic Outcomes of Asymmetric Dorsal Preservation for Correction of I-Shaped Crooked Nose Deformity.","authors":"Mehmet Akif Alan, Hilal Yücel","doi":"10.4274/tao.2023.2022-12-1","DOIUrl":"https://doi.org/10.4274/tao.2023.2022-12-1","url":null,"abstract":"<p><strong>Objective: </strong>The study was designed to evaluate the effectiveness of the asymmetric dorsal preservation technique for correcting I-shaped crooked nose deformity (CND).</p><p><strong>Methods: </strong>Patients with I-shaped CND who underwent asymmetric dorsal preservation in the period from September 2020 to September 2021 were included in this retrospective study. The Rhinomanometry and Standardized Cosmesis and Health Nasal Outcomes Survey (SCHNOS) was used to assess the outcomes. Deviation angle (DA) measurements were used to evaluate the degree of crookedness. The results were recorded both preoperatively and 12 months postoperatively.</p><p><strong>Results: </strong>Twenty-three patients were included in the study. Total nasal airflow and long-side nasal airflow were significantly higher 12 months postoperatively (p=0.001 each). Total nasal resistance, long-side nasal resistance, SCHNOS scores and DA measurements were significantly lower 12 months postoperatively (p<0.001 each).</p><p><strong>Conclusion: </strong>Asymmetric dorsal preservation is a successful alternative technique for correcting I-shaped CND and achieving optimal aesthetic and functional outcomes.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/3b/tao-61-14.PMC10424583.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10388762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate bilateral superior and recurrent laryngeal nerves for tumor spread in patients of advanced-stage laryngeal carcinoma undergoing surgical resection.
Methods: A prospective study was conducted including biopsy-proven cases of laryngeal squamous cell carcinoma (SCC) that were planned for total laryngectomy. Patients with metachronous or synchronous SCC were excluded from the study. All patients underwent total laryngectomy, where both superior and recurrent laryngeal nerves were harvested along with the specimen, and the proximal ends of the nerves were marked for reference. Perineural invasion (PNI) was assessed in nerves within the tumor and in bilateral extra-laryngeal nerves.
Results: The study included 22 patients with a mean age of 58 years. Intra-tumoral PNI was found in 7 of the 22 cases (32%). The free nerve margins of superior and recurrent laryngeal nerves, which were examined from proximal to distal orientation, showed no tumor infiltration in any of the cases.
Conclusion: Perineural invasion of minor nerves constitutes a major pathway of spread. On the contrary, invasion of superior or recurrent laryngeal nerves does not constitute a route for tumor spread. Hence, there is no need to extend the surgical boundary for total laryngectomy to include these major nerves separately.
{"title":"Perineural Invasion of Superior and Inferior Laryngeal Nerves in Advanced Stage Squamous Cell Carcinoma of the Larynx: A Case Series and Review.","authors":"Avinash Shekhar Jaiswal, Sumanth Bollu, Shilpi Budhiraja, Seema Kaushal, Kapil Sikka, Alok Thakar, Hitesh Verma","doi":"10.4274/tao.2023.2023-2-12","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-2-12","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate bilateral superior and recurrent laryngeal nerves for tumor spread in patients of advanced-stage laryngeal carcinoma undergoing surgical resection.</p><p><strong>Methods: </strong>A prospective study was conducted including biopsy-proven cases of laryngeal squamous cell carcinoma (SCC) that were planned for total laryngectomy. Patients with metachronous or synchronous SCC were excluded from the study. All patients underwent total laryngectomy, where both superior and recurrent laryngeal nerves were harvested along with the specimen, and the proximal ends of the nerves were marked for reference. Perineural invasion (PNI) was assessed in nerves within the tumor and in bilateral extra-laryngeal nerves.</p><p><strong>Results: </strong>The study included 22 patients with a mean age of 58 years. Intra-tumoral PNI was found in 7 of the 22 cases (32%). The free nerve margins of superior and recurrent laryngeal nerves, which were examined from proximal to distal orientation, showed no tumor infiltration in any of the cases.</p><p><strong>Conclusion: </strong>Perineural invasion of minor nerves constitutes a major pathway of spread. On the contrary, invasion of superior or recurrent laryngeal nerves does not constitute a route for tumor spread. Hence, there is no need to extend the surgical boundary for total laryngectomy to include these major nerves separately.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/99/tao-61-20.PMC10424581.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10366923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4274/tao.2022.2022-7-7
Débora Cristina Gaspar Gonçalves, Tiago Soares Santos, Vera Claúdia Miranda Silva, Hugo Narcy Amaral Amorim Costa, Carlos Magalhães Ferreira Carvalho
Frontal sinus keratoma or cholesteatoma is a rare disease of paranasal sinuses and presents as a slow-growing mass that becomes symptomatic as it grows to the surrounding structures. Intracranial complications are not a common presentation and are potentially life-threatening. Frequently the final diagnosis is only made intraoperatively because several other frontal sinus tumors behave likewise. Definitive treatment requires complete removal of the keratoma, and a combined endoscopic and external frontal sinus approach is a good treatment option. In this report, we presented a 68-year-old female with frontal sinus cholesteatoma with diagnostic and therapeutic features of this pathology with the review of the literature.
{"title":"Frontal Sinus Cholesteatoma Presenting with Intracranial and Orbital Complications: Diagnosis and Treatment.","authors":"Débora Cristina Gaspar Gonçalves, Tiago Soares Santos, Vera Claúdia Miranda Silva, Hugo Narcy Amaral Amorim Costa, Carlos Magalhães Ferreira Carvalho","doi":"10.4274/tao.2022.2022-7-7","DOIUrl":"https://doi.org/10.4274/tao.2022.2022-7-7","url":null,"abstract":"<p><p>Frontal sinus keratoma or cholesteatoma is a rare disease of paranasal sinuses and presents as a slow-growing mass that becomes symptomatic as it grows to the surrounding structures. Intracranial complications are not a common presentation and are potentially life-threatening. Frequently the final diagnosis is only made intraoperatively because several other frontal sinus tumors behave likewise. Definitive treatment requires complete removal of the keratoma, and a combined endoscopic and external frontal sinus approach is a good treatment option. In this report, we presented a 68-year-old female with frontal sinus cholesteatoma with diagnostic and therapeutic features of this pathology with the review of the literature.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/9f/tao-60-234.PMC10339268.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10183555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4274/tao.2022.2022-12-3
Mehmet Emre Sivrice, Hasan Yasan, Yusuf Çağdaş Kumbul, Onur Ertunç, Sarper Sayın
Objective: Prostate-specific membrane antigen (PSMA) is a cell membrane protein expressed by prostate tissues. It is not prostate specific and is also expressed by some non-prostatic solid neoplasms. Our study aimed to investigate the potential role of PSMA in salivary gland tumors.
Methods: The present study was designed to retrospectively analyze our cases that presented with salivary gland tumors. The files of 105 patients were reviewed and their paraffin embedded blocks were retrieved from the pathology department. Immunohistochemical examination and staining were done using PSMA antibody. Tumor tissue PSMA immunohistochemical staining was scored semi-quantitatively with the modified quartile approach. Negative staining was scored 0, >0% and ≤25% tissue expression was considered weak (score 1), >25% and ≤50% tissue expression was considered mild (score 2), >50% and ≤75% tissue expression was considered moderate (score 3), and >75% tissue expression was considered strong (score 4).
Results: Eighty-eight patients (55 males, 33 females) were included in the study. Forty-eight patients had pleomorphic adenoma (PA), 35 had Warthin's tumor (WT), two had mucoepidermoid carcinoma, two had adenoid cystic carcinoma, and one had squamous cell carcinoma. There was statistically significant difference in terms of PSMA expression between PA and WT (p=0.003). PSMA expression was high in PA and absent in WT.
Conclusion: PSMA is a potential source of inspiration for future studies on the development of novel diagnostic and theranostic investigations of salivary gland tumors. Prospective studies targeting intratumoral PSMA in salivary gland tumors should be planned.
{"title":"The Importance of Prostate-Specific Membrane Antigen Expression in Salivary Gland Tumors.","authors":"Mehmet Emre Sivrice, Hasan Yasan, Yusuf Çağdaş Kumbul, Onur Ertunç, Sarper Sayın","doi":"10.4274/tao.2022.2022-12-3","DOIUrl":"https://doi.org/10.4274/tao.2022.2022-12-3","url":null,"abstract":"<p><strong>Objective: </strong>Prostate-specific membrane antigen (PSMA) is a cell membrane protein expressed by prostate tissues. It is not prostate specific and is also expressed by some non-prostatic solid neoplasms. Our study aimed to investigate the potential role of PSMA in salivary gland tumors.</p><p><strong>Methods: </strong>The present study was designed to retrospectively analyze our cases that presented with salivary gland tumors. The files of 105 patients were reviewed and their paraffin embedded blocks were retrieved from the pathology department. Immunohistochemical examination and staining were done using PSMA antibody. Tumor tissue PSMA immunohistochemical staining was scored semi-quantitatively with the modified quartile approach. Negative staining was scored 0, >0% and ≤25% tissue expression was considered weak (score 1), >25% and ≤50% tissue expression was considered mild (score 2), >50% and ≤75% tissue expression was considered moderate (score 3), and >75% tissue expression was considered strong (score 4).</p><p><strong>Results: </strong>Eighty-eight patients (55 males, 33 females) were included in the study. Forty-eight patients had pleomorphic adenoma (PA), 35 had Warthin's tumor (WT), two had mucoepidermoid carcinoma, two had adenoid cystic carcinoma, and one had squamous cell carcinoma. There was statistically significant difference in terms of PSMA expression between PA and WT (p=0.003). PSMA expression was high in PA and absent in WT.</p><p><strong>Conclusion: </strong>PSMA is a potential source of inspiration for future studies on the development of novel diagnostic and theranostic investigations of salivary gland tumors. Prospective studies targeting intratumoral PSMA in salivary gland tumors should be planned.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/aa/e2/tao-60-206.PMC10339265.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4274/tao.2022.2022-10-1
Samy Elwany, Ziad Mandour, Ahmed Aly Ibrahim, Remon Bazak
Objective: Transection or ablation of the posterior nasal nerve (TRPN) has been described as an adjunctive tool to reduce the symptoms of intractable allergic rhinitis (AR). The procedure, however, requires surgical skill and carries the risk of bleeding from the sphenopalatine artery. The aim of the present study is to describe radiofrequency ablation of the peripheral branches of the posterior nasal nerves within the inferior turbinates (RAPN) as an effective easier alternative to TRPN.
Methods: The procedure was performed on 24 patients with intractable AR. Nasal reactivity was tested by cold dry air (CDA) provocation before and 12 months after the radiofrequency procedure. Visual analog scale and acoustic rhinometry were used to measure the changes in nasal reactivity subjectively and objectively.
Results: Worsening of nasal symptoms following CDA provocation had significantly decreased after the RAPN procedure. Likewise, postoperative decrease in nasal volumes and minimal cross-sectional areas after CDA provocation were significantly less than the corresponding preoperative values.
Conclusion: RAPN effectively reduces nasal reactivity in patients with AR. The procedure is simple, minimally invasive, and can be performed under local or general anesthesia.
{"title":"Nasal Reactivity After Radiofrequency Ablation of Peripheral Branches of Posterior Nasal Nerve.","authors":"Samy Elwany, Ziad Mandour, Ahmed Aly Ibrahim, Remon Bazak","doi":"10.4274/tao.2022.2022-10-1","DOIUrl":"https://doi.org/10.4274/tao.2022.2022-10-1","url":null,"abstract":"<p><strong>Objective: </strong>Transection or ablation of the posterior nasal nerve (TRPN) has been described as an adjunctive tool to reduce the symptoms of intractable allergic rhinitis (AR). The procedure, however, requires surgical skill and carries the risk of bleeding from the sphenopalatine artery. The aim of the present study is to describe radiofrequency ablation of the peripheral branches of the posterior nasal nerves within the inferior turbinates (RAPN) as an effective easier alternative to TRPN.</p><p><strong>Methods: </strong>The procedure was performed on 24 patients with intractable AR. Nasal reactivity was tested by cold dry air (CDA) provocation before and 12 months after the radiofrequency procedure. Visual analog scale and acoustic rhinometry were used to measure the changes in nasal reactivity subjectively and objectively.</p><p><strong>Results: </strong>Worsening of nasal symptoms following CDA provocation had significantly decreased after the RAPN procedure. Likewise, postoperative decrease in nasal volumes and minimal cross-sectional areas after CDA provocation were significantly less than the corresponding preoperative values.</p><p><strong>Conclusion: </strong>RAPN effectively reduces nasal reactivity in patients with AR. The procedure is simple, minimally invasive, and can be performed under local or general anesthesia.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/33/tao-60-181.PMC10339264.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10201668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.4274/tao.2022.2022-8-6
Deniz Uğur Cengiz, İsmail Demir, Sümeyye Demirel, Sanem Can Çolak, Tuğba Emekçi, Tuba Bayındır
Objective: To investigate the effects of dizziness on sleep quality and psychological status in patients with benign paroxysmal positional vertigo (BPPV) and to evaluate its relationship with falls.
Methods: A Demographic Data Form, a Visual Vertigo Analog Scale, the Falls Efficacy Scale - International (FES-I), the Hospital Anxiety and Depression Scale (HADS), and the Pittsburgh Sleep Quality Index (PSQI) were administered in 102 individuals diagnosed with BPPV by videonystagmography test. The same scales were applied to 75 healthy volunteers as the control group, and the two groups were compared. The BPPV group was divided into two groups as posterior canal and lateral canal BPPV. These two groups were compared among themselves and with the control group.
Results: A statistically significant difference was found between the BPPV and control groups, the lateral canal BPPV and posterior canal BPPV groups, the lateral canal BPPV and control groups, and the posterior canal BPPV and control groups in terms of total scores of the PSQI, the FES-I, and the HADS (p<0.001). In the regression model, the FES-I score was fully explained by the PSQI and HADS scores (p<0.001).
Conclusion: BPPV significantly affects sleep quality, psychological state, and the risk of fall. The negative effects of BPPV restrict daily living activities, affect the prognosis of the disease, and increase the risk of falling. Considering that psychiatric issues and sleep problems increase the risk of falling in individuals with BPPV, counseling services on this issue would reduce the incidence of falls and related injuries.
{"title":"Investigation of the Relationship Between BPPV with Anxiety, Sleep Quality and Falls.","authors":"Deniz Uğur Cengiz, İsmail Demir, Sümeyye Demirel, Sanem Can Çolak, Tuğba Emekçi, Tuba Bayındır","doi":"10.4274/tao.2022.2022-8-6","DOIUrl":"https://doi.org/10.4274/tao.2022.2022-8-6","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of dizziness on sleep quality and psychological status in patients with benign paroxysmal positional vertigo (BPPV) and to evaluate its relationship with falls.</p><p><strong>Methods: </strong>A Demographic Data Form, a Visual Vertigo Analog Scale, the Falls Efficacy Scale - International (FES-I), the Hospital Anxiety and Depression Scale (HADS), and the Pittsburgh Sleep Quality Index (PSQI) were administered in 102 individuals diagnosed with BPPV by videonystagmography test. The same scales were applied to 75 healthy volunteers as the control group, and the two groups were compared. The BPPV group was divided into two groups as posterior canal and lateral canal BPPV. These two groups were compared among themselves and with the control group.</p><p><strong>Results: </strong>A statistically significant difference was found between the BPPV and control groups, the lateral canal BPPV and posterior canal BPPV groups, the lateral canal BPPV and control groups, and the posterior canal BPPV and control groups in terms of total scores of the PSQI, the FES-I, and the HADS (p<0.001). In the regression model, the FES-I score was fully explained by the PSQI and HADS scores (p<0.001).</p><p><strong>Conclusion: </strong>BPPV significantly affects sleep quality, psychological state, and the risk of fall. The negative effects of BPPV restrict daily living activities, affect the prognosis of the disease, and increase the risk of falling. Considering that psychiatric issues and sleep problems increase the risk of falling in individuals with BPPV, counseling services on this issue would reduce the incidence of falls and related injuries.</p>","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/81/tao-60-199.PMC10339271.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9825152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}