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Prognostic and Clinical Role of Contrast Enhancement on Magnetic Resonance Imaging in Patients with Bell's Palsy. 磁共振造影增强对贝尔麻痹患者预后及临床的影响。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-06-01 Epub Date: 2022-08-31 DOI: 10.4274/tao.2022.2022-2-14
Volkan Yücel, Serra Özbal Güneş, Kemal Keseroğlu, Ömer Bayır, Mehmet Furkan Çırakoğlu, Emel Çadallı Tatar, Güleser Saylam, Sevilay Karahan, Orhan Yılmaz, Mehmet Hakan Korkmaz

Objective: To investigate the prognostic value of the magnetic resonance imaging in Bell's palsy patients.

Methods: Patients who were diagnosed and treated with Bell's palsy between October 2013 and March 2016 retrospectively selected. House-Brackmann grades, pre- and post-treatment pure tone audiograms, stapedial reflexes were analyzed and magnetic resonance imaging (MRI) scans with gadolinium-based contrast agents were evaluated. Contrast-enhanced segments of the facial nerve were determined. MRI findings were compared statistically with pre- and post-treatment grade, recurrence rate of Bell's palsy, MRI scanning timing, presence of stapes reflexes and posttreatment recovery data.

Results: No significant correlation was observed between pretreatment House-Brackmann grades and enhancement (p>0.05). Similarly, there was no significant correlation between clinical recovery and enhancement (p>0.05). Also, no significant correlation was observed between MRI scanning time, the recurrence rate of Bell's palsy and MRI findings (p>0.05). None of the MRIs showed neoplastic contrast enhancement.

Conclusion: The routine use of the contrast-enhanced temporal MRI is not recommended in the diagnosis and monitoring of Bell's palsy patients, because the contrast enhancement pattern of the facial nerve has no effect on the prognosis of Bell's palsy. MRI should be used in cases that do not heal despite treatment, for the differential diagnosis of facial nerve tumors and in patients who are candidates for surgical decompression.

目的:探讨磁共振成像对贝尔麻痹患者预后的价值。方法:回顾性选择2013年10月至2016年3月诊断并治疗的贝尔麻痹患者。分析House-Brackmann评分、治疗前和治疗后的纯音听音图、镫骨反射,并评估钆基造影剂的磁共振成像(MRI)扫描。对比增强的面神经段被确定。将MRI结果与治疗前后的分级、贝尔麻痹的复发率、MRI扫描时间、镫骨反射的存在以及治疗后的恢复数据进行统计学比较。结果:预处理House-Brackmann评分与增强无显著相关(p>0.05)。同样,临床恢复与增强无显著相关性(p>0.05)。MRI扫描时间、贝尔麻痹复发率与MRI表现无显著相关性(p>0.05)。mri均未显示肿瘤增强。结论:由于面神经的对比增强模式对贝尔麻痹的预后没有影响,不建议常规使用颞叶MRI增强对贝尔麻痹的诊断和监测。MRI应用于治疗后仍不能愈合的病例,用于面神经肿瘤的鉴别诊断以及需要手术减压的患者。
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引用次数: 0
Glass Particles in the Nasal Cavity for 30 Years and Squamous Cell Carcinoma: Is There a Relationship? 30年来鼻腔内的玻璃颗粒与鳞状细胞癌有关系吗?
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-06-01 Epub Date: 2022-08-31 DOI: 10.4274/tao.2022.2022-1-12
Selçuk Yıldız, Perçin Serhat Yergin, Ayşegül Verim, Lütfü Şeneldir

Nasal cavity tumors constitute a very small part of head and neck malignancies. Although paranasal sinus tumors due to the presence of backward foreign bodies, neoplasms of nasal cavity associated with a foreign body are extremely rare. In this article, we presented a rare case of carcinoma in the right nasal cavity which includes glass particles inside it, and the role of glass particles in carcinogenesis was discussed. The patient was a 55-year-old male with history of a car accident 30 years ago. During right medial maxillectomy via a right lateral rhinotomy approach, three pieces of glass beads, approximately 0.5 cm in size, were removed from the inside of the mass. The patient had also under gone postoperative radiotherapy. No complication emerged during the postoperative recovery period. The patient had been followed up with no finding of local recurrence for 12 months.

鼻腔肿瘤在头颈部恶性肿瘤中只占很小的一部分。虽然鼻窦肿瘤是由于后向异物的存在,但鼻腔肿瘤合并异物是极为罕见的。本文报告了一例罕见的右鼻腔癌,其中含有玻璃颗粒,并讨论了玻璃颗粒在癌变中的作用。患者男性,55岁,30年前曾发生过车祸。在通过右外侧鼻切开术进行右内侧上颌切除术时,从肿块内部取出约0.5 cm大小的三颗玻璃珠。患者术后也接受了放疗。术后恢复期无并发症发生。患者随访12个月,未发现局部复发。
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引用次数: 0
3D Model to Understand the Diagnosis and Treatment of Horizontal Canal BPPV. 通过三维模型了解水平管BPPV的诊断和治疗。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-06-01 Epub Date: 2022-08-31 DOI: 10.4274/tao.2022.2021-10-11
Enis Alpin Güneri, Salim Hancı, Yüksel Olgun, Serpil Mungan Durankaya

Objective: Our primary objective was to develop a three-dimensional (3D) model of the vestibular labyrinth to understand the pathophysiological mechanisms of benign paroxysmal positional vertigo (BPPV) observed during common diagnostic positional tests. We secondarily aimed to monitor the effects of the repositioning maneuvers and use this tool in teaching.

Methods: A 3D model of a human semicircular canals (SSCs) system was created by 3D printing the core and assembling it with silicone tubing filled with lubricant oil containing colored small stones in the lumen mimicking otoconia. We used the model in horizontal canal BPPV diagnostic tests and therapeutic maneuvers. The working mechanism of the model we designed was recorded with video.

Results: The model allowed for a clear display of the anatomy and the respective orientations of the SSCs. Otolith movement in the horizontal canals could be imitated during diagnostic positional tests (Dix-Hallpike and Pagnini-McClure) and therapeutic maneuvers (Epley, Semont, Lempert and Gufoni).

Conclusion: As well as helping to understand the anatomy and physiology of the SSCs, this simple 3D model also provides a teaching tool for the diagnosis and treatment of BPPV. The mechanism of horizontal canal canalithiasis and the effect of therapeutic repositioning maneuvers could be clearly observed by watching the markers in the lumen demonstrating the progress of otolith movements with changes in head position relative to gravity.

目的:我们的主要目的是建立一个前庭迷路的三维(3D)模型,以了解在常见诊断性体位试验中观察到的良性阵发性体位性眩晕(BPPV)的病理生理机制。我们的第二目的是监测重新定位动作的效果,并在教学中使用这个工具。方法:3D打印人体半规管(ssc)系统的核心,并将其与填充润滑油的硅胶管组装在一起,硅胶管中含有彩色小结石,模拟耳聋。我们将该模型用于水平管BPPV诊断试验和治疗操作。用视频记录了我们设计的模型的工作机理。结果:该模型能够清晰地显示ssc的解剖结构和各自的方向。在诊断性定位试验(Dix-Hallpike和Pagnini-McClure)和治疗性操作(Epley, Semont, Lempert和Gufoni)中,耳石在水平管中的运动可以被模仿。结论:该简单的三维模型不仅有助于了解SSCs的解剖和生理,而且为BPPV的诊断和治疗提供了教学工具。通过观察耳腔内显示耳石运动随头部相对重力位置变化的标志物,可以清楚地观察水平管管结石的发生机制和治疗性重新定位的效果。
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引用次数: 0
Promising Outcome of Radiation Therapy for Chondroblastoma of Temporal Bone in Childhood: A Case Report. 儿童颞骨成软骨细胞瘤放射治疗的前景:1例报告。
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-06-01 Epub Date: 2022-08-31 DOI: 10.4274/tao.2022.2022-2-3
F Ceyda Akın Öçal, Bülent Satar, Ertuğrul Çelik, Uğur Bozlar, Murat Beyzadeoğlu

Chondroblastoma is a rare cartilaginous benign bone tumor. Chondroblastoma in the temporal bone is also quite rare. Total excision is the main treatment. Data regarding tumor response to radiation therapy (RT) is insufficient. We describe a case of chondroblastoma that was treated with RT following subtotal tumor resection. In this case, the patient was a 14-year-old male who presented with a three-month history of ear fullness and hearing loss in his right ear. Magnetic resonance imaging revealed a mass partly filling the right external auditory canal and the inferior part of the middle ear. Histopathological findings indicated chondroblastoma. Subtotal tumor resection was performed due to risk of complications. RT was planned upon the growth of the tumor during follow-up. Treatment with subtotal resection and postoperative RT has been successful and the patient had no recurrence in the course of the 12-year follow-up. In chondroblastoma, complete surgical resection is still the gold standard. But the success of subtotal resection followed by adjuvant RT should also be kept in mind for cases where the total excision would pose high morbidity.

成软骨细胞瘤是一种罕见的软骨良性骨肿瘤。颞骨的成软骨细胞瘤也很少见。全切除是主要的治疗方法。关于肿瘤对放射治疗(RT)反应的数据不足。我们描述了一个病例的成软骨细胞瘤,治疗与放射治疗后,肿瘤次全切除。在这个病例中,患者是一名14岁的男性,他表现出三个月的耳部充盈和右耳听力丧失的历史。磁共振成像显示肿块部分填满右外耳道和中耳下部。组织病理学结果提示成软骨细胞瘤。考虑到并发症的风险,行肿瘤次全切除。随访时根据肿瘤生长情况计划RT。经次全切除和术后RT治疗成功,患者在12年随访期间无复发。对于成软骨细胞瘤,完全手术切除仍然是金标准。但是,对于全切除会造成高发病率的病例,也应该记住次全切除后辅助RT的成功。
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引用次数: 0
Impact of Functional and Aesthetic Factors on Patient Satisfaction in Septorhinoplasty 鼻中隔成形术中功能和美学因素对患者满意度的影响
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-03-01 DOI: 10.4274/tao.2022.2021-12-10
Özgür Kemal, E. Tahir, E. Kavaz, Huseyin Karabulut
Objective: This study aimed to differentiate the functional or aesthetic factors affecting the result of septorhinoplasty and to determine the most important factor related to patient satisfaction. Methods: Rhinoplasty Outcome Evaluation (ROE) and Visual Analog Scale (VAS) for obstruction (VAS-O) and for appearance (VAS-A) were administered to fifty-five patients undergoing septorhinoplasty preoperatively and six months after the surgery. VAS scores were evaluated as follows: VAS-O (0: unblocked, 10: completely blocked) and VAS-A (0: worst appearance, 10: best appearance). ROE scores were calculated between 0 and 100. In order to examine the relationship between the measurements and determine the most powerful item that affects the overall ROE score, path analysis was performed, and the path coefficients were calculated. Results: The mean VAS-O and VAS-A scores before and after surgery were 6.85 and 4.36, and 3.91 and 7.22, respectively (p<0.001). The absolute value of mean difference was greater for VAS-A (-3.31) than VAS-O (-2.49), which also means appearance scores were more widely affected. The mean ROE score was increased from 46.36±9.28 to 78.85±11.70. VAS-A score had a significant impact on the overall ROE score (β=0.782, p=0.001), while the VAS-O score had no impact. The least effective item on the overall ROE score was item 2 (β=0.445), while the other items related to aesthetic outcome had higher Path coefficients. Conclusion: Although septorhinoplasty provides satisfactory results in both functional and aesthetic aspects, patients are more satisfied with the cosmetic outcomes.
目的:本研究旨在区分影响鼻中隔成形术效果的功能因素和美学因素,并确定影响患者满意度的最重要因素。方法:对55例鼻中隔成形术患者术前和术后6个月分别进行鼻中隔成形术疗效评价(ROE)和鼻中隔阻塞视觉模拟评分(VAS- o)和外观视觉模拟评分(VAS- a)。VAS评分分为VAS- o(0:未阻塞,10:完全阻塞)和VAS- a(0:最差外观,10:最佳外观)。ROE评分在0 ~ 100之间计算。为了检验测量之间的关系并确定影响总体ROE得分的最强大项目,进行了路径分析,并计算了路径系数。结果:手术前后VAS-O和VAS-A平均评分分别为6.85和4.36,3.91和7.22 (p<0.001)。VAS-A的均值差绝对值(-3.31)大于VAS-O的均值差绝对值(-2.49),这也意味着外观评分受到的影响更广泛。平均ROE评分由46.36±9.28分上升至78.85±11.70分。VAS-A评分对总ROE评分有显著影响(β=0.782, p=0.001),而VAS-O评分无影响。对整体ROE得分影响最小的项目是项目2 (β=0.445),而与审美结果相关的其他项目具有更高的Path系数。结论:虽然鼻中隔成形术在功能和美观方面都取得了令人满意的效果,但患者对美容效果更满意。
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引用次数: 1
Instantaneous Gain in Video Head Impulse Test: A Reliability Study 视频头脉冲测试中的瞬时增益:可靠性研究
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-03-01 DOI: 10.4274/tao.2022.2022-1-4
Burak Kabiş, H. Tutar, B. Gündüz, S. Aksoy
Objective: Vestibulo-ocular reflex gain at 40, 60, and 80 ms following the head movement start is calculated as the instantaneous gain. The purpose of this study was to investigate the reliability of instantaneous gain values at 40, 60, and 80 ms with testing and retesting in healthy adults. Methods: The study was conducted with Interacoustics EyeSeeCam vHIT (Interacoustics, Denmark), and 42 healthy adults were evaluated twice at half-hour intervals (test and retest) by the same practitioner. Agreement of mean gain, gain asymmetry, and instantaneous gain was evaluated using a paired samples t-test. Results: Mean age of the participants was 33.62±11.17; 38.1% were male and 61.9% were female. In the degree of the agreement, paired sample correlation (r) between test and retest results of the horizontal semicircular canals was found to be higher than those of the vertical semicircular canals. Moreover, the highest correlation between test and retest for instantaneous gain, calculated for only horizontal semicircular canals, was found at 80 ms on each side (0.791; 0.838, right and left, respectively), while the lowest correlation between these parameters was found between the gain asymmetry values. Conclusion: The video head impulse test used in studies calculates the mean gain in approximately at 60 ms. However, the higher correlation between mean gain values at 80 ms in our findings indicates that gain calculation strategies and techniques for latencies should be discussed. Additionally, the low correlation of vertical semicircular canals for mean gain and gain asymmetry between semicircular canal pairs, which clearly shows that more standard and more reliable methods should be developed.
目的:计算头部运动开始后40,60,80ms的前庭眼反射增益作为瞬时增益。本研究的目的是研究在健康成人中测试和重新测试40、60和80 ms瞬时增益值的可靠性。方法:采用Interacoustics eyeeseecam vHIT (Interacoustics,丹麦)软件,对42名健康成人进行每隔半小时两次(测试和再测试)的评估。使用配对样本t检验评估平均增益、增益不对称和瞬时增益的一致性。结果:参与者平均年龄为33.62±11.17岁;男性占38.1%,女性占61.9%。在一致性程度上,水平半规管测试与重测结果的配对样本相关性(r)高于垂直半规管。此外,仅对水平半规管计算的瞬时增益的测试和重新测试之间的相关性最高,在每侧80 ms时发现(0.791;0.838,分别为右、左),而增益不对称值之间的相关性最低。结论:研究中使用的视频头脉冲测试计算了大约在60ms的平均增益。然而,在我们的研究结果中,80毫秒时的平均增益值之间的较高相关性表明,应该讨论增益计算策略和延迟技术。此外,垂直半规管与平均增益的相关性较低,半规管对之间的增益不对称,这清楚地表明需要开发更标准和更可靠的方法。
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引用次数: 0
Paranasal Sinus Fungus Ball, Anatomical Variations and Dental Pathologies: Is There Any Relation? 副鼻窦真菌球、解剖变异与口腔病理有关系吗?
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-03-01 DOI: 10.4274/tao.2022.2021-11-8
Bayram Şahi̇n, Ş. Çomoğlu, Said Sönmez, K. Değer, Meryem Nesil Keleş Türel
Objective: The purpose of this study was to investigate the relationship between anatomical variations and the fungus ball (FB), and the association between odontogenic etiologies and the maxillary sinus FB. Methods: We analyzed the clinical records of 66 patients who underwent endoscopic sinus surgery for FB. The anatomical variations determined were nasal septal deviation (NSD) and direction, presence of Onodi and Haller cell, concha bullosa and lateral recess of the sphenoid sinus. Further, dental X-ray records were reviewed to detect any possible odontogenic etiologies in patients with maxillary sinus FBs. Results: There were 41 female and 25 male patients. Positive fungal culture was found in 60 patients (91%) and the causative fungus was Aspergillus species in all cases. The correlation between NSD and localization of the maxillary sinus FB was statistically significant (p=0.0409). Maxillary sinus FB was more common on the concave side of the NSD. Presence of dental pathologies was significantly associated with maxillary sinus FB compared to the healthy side (p=0.0011). For sphenoid sinus FB, NSD was detected in a similar number for both the affected and unaffected side and there were no significant correlations (p>0.05). However, the relationship between sphenoid sinus FB and presence of lateral recess was significant (p=0.0262). Conclusion: Our study revealed that the maxillary sinus FB was more common on the concave side of the deviated septum. Also, dental pathologies or a presence of dental treatment history were associated with maxillary sinus FB.
目的:探讨上颌窦真菌球的解剖变异与真菌球的关系,以及牙源性病因与真菌球的关系。方法:我们分析66例接受鼻内窥镜手术治疗FB的患者的临床记录。解剖变异包括鼻中隔偏曲(NSD)和方向,Onodi和Haller细胞的存在,鼻甲大泡和蝶窦外侧隐窝。此外,回顾了牙科x线记录,以发现上颌窦FBs患者的任何可能的牙源性病因。结果:女性41例,男性25例。真菌培养阳性60例(91%),病原菌均为曲霉属。NSD与上颌窦FB定位的相关性有统计学意义(p=0.0409)。上颌窦FB多见于NSD的凹侧。与健康侧相比,口腔病变的存在与上颌窦FB显著相关(p=0.0011)。对于蝶窦FB, NSD在受病侧和未受病侧的检出率相似,无显著相关性(p < 0.05)。然而,蝶窦FB与侧隐窝的存在有显著的关系(p=0.0262)。结论:上颌窦FB多见于偏隔凹侧。此外,口腔病理或牙科治疗史的存在与上颌窦FB有关。
{"title":"Paranasal Sinus Fungus Ball, Anatomical Variations and Dental Pathologies: Is There Any Relation?","authors":"Bayram Şahi̇n, Ş. Çomoğlu, Said Sönmez, K. Değer, Meryem Nesil Keleş Türel","doi":"10.4274/tao.2022.2021-11-8","DOIUrl":"https://doi.org/10.4274/tao.2022.2021-11-8","url":null,"abstract":"Objective: The purpose of this study was to investigate the relationship between anatomical variations and the fungus ball (FB), and the association between odontogenic etiologies and the maxillary sinus FB. Methods: We analyzed the clinical records of 66 patients who underwent endoscopic sinus surgery for FB. The anatomical variations determined were nasal septal deviation (NSD) and direction, presence of Onodi and Haller cell, concha bullosa and lateral recess of the sphenoid sinus. Further, dental X-ray records were reviewed to detect any possible odontogenic etiologies in patients with maxillary sinus FBs. Results: There were 41 female and 25 male patients. Positive fungal culture was found in 60 patients (91%) and the causative fungus was Aspergillus species in all cases. The correlation between NSD and localization of the maxillary sinus FB was statistically significant (p=0.0409). Maxillary sinus FB was more common on the concave side of the NSD. Presence of dental pathologies was significantly associated with maxillary sinus FB compared to the healthy side (p=0.0011). For sphenoid sinus FB, NSD was detected in a similar number for both the affected and unaffected side and there were no significant correlations (p>0.05). However, the relationship between sphenoid sinus FB and presence of lateral recess was significant (p=0.0262). Conclusion: Our study revealed that the maxillary sinus FB was more common on the concave side of the deviated septum. Also, dental pathologies or a presence of dental treatment history were associated with maxillary sinus FB.","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"60 1","pages":"23 - 28"},"PeriodicalIF":0.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41635991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Treatment Results and Postoperative Complications of Single-Stage Tracheal Resection in Adolescent Patients with Post-Intubation Tracheal Stenosis, Compared to Adults 青少年气管插管后狭窄一期气管切除术的治疗结果及术后并发症与成人的比较
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-03-01 DOI: 10.4274/tao.2022.2022-2-8
Mustafa Aslıer, Muhammed Furkan Yıldırım, H. Coşkun
Objective: The purpose of this study was to analyze the treatment outcomes and postoperative complications of tracheal resection in patients under the age of 19 years with post-intubation tracheal stenosis, and to compare the results with those of adults. Methods: Data were retrospectively retrieved from the medical records, including demographic characteristics, perioperative features, any postoperative complications and follow-up statuses of the patients. Treatment results and postoperative complications were compared between adolescent and adult groups. Results: Overall, anastomotic and non-anastomotic complication rates in the adolescent group and the adult group were 40%, 40%, 10% and 63%, 44.4%, 33.3%, respectively. Overall treatment success rates based on tracheostomy tube and tracheal stent free status were 90% and 92.6% in adolescent and adults, respectively. Conclusion: Treatment success rates and incidence of anastomotic complications were found similar in patients under the age of 19 years and adult patients who underwent single-stage tracheal resection and end to end anastomosis for treatment of post-intubation tracheal stenosis.
目的:分析19岁以下气管插管后狭窄患者气管切除术的治疗效果和术后并发症,并与成人进行比较。方法:回顾性检索病历资料,包括患者的人口学特征、围手术期特征、术后并发症和随访情况。比较青少年组和成人组的治疗结果和术后并发症。结果:总体而言,青少年组和成人组的吻合口和非吻合口并发症发生率分别为40%、40%、10%和63%、44.4%、33.3%。在青少年和成人中,基于气管造口管和无气管支架状态的总体治疗成功率分别为90%和92.6%。结论:年龄在19岁以下的患者和接受单期气管切除和端对端吻合治疗插管后气管狭窄的成年患者的治疗成功率和吻合口并发症发生率相似。
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引用次数: 0
A Rare Sinonasal Malignancy: Biphenotypic Sinonasal Sarcoma 罕见的鼻窦恶性肿瘤:双表型鼻窦肉瘤
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-03-01 DOI: 10.4274/tao.2022.2021-11-9
Esra Aydın Sudabatmaz, M. A. Abakay, A. Koçbıyık, I. Sayin, Z. Yazıcı
Biphenotypic sinonasal sarcoma (BSNS), which has been described in the recent years, is a low-grade spindle cell sinonasal sarcoma characterized by rare neural and myogenic features. It has a slow growth pattern; does not metastasize, but local recurrences are common after surgery. Non-specificity of examination findings and symptoms and similarities of its histopathological features with other spindle cell sarcomas, neural tumors, and skeletal muscle-derived tumors involving the nasal cavity make the diagnosis difficult. Therefore, histopathological features should be evaluated together with immunophenotyping and molecular studies for differential diagnosis. There are very few BSNS cases or case series in the literature. In this report, we reported our clinical approach to a case with BSNS in the right nasal cavity and the histopathological features of the disease in the light of the current literature.
近年来出现的双表型鼻窦肉瘤(BSNS)是一种低度梭形细胞鼻窦肉瘤,具有罕见的神经和肌源性特征。它具有缓慢的增长模式;不会转移,但手术后局部复发很常见。检查结果和症状的非特异性,以及其组织病理学特征与其他梭形细胞肉瘤、神经肿瘤和涉及鼻腔的骨骼肌衍生肿瘤的相似性,使诊断变得困难。因此,组织病理学特征应与免疫表型和分子研究一起进行评估,以进行鉴别诊断。文献中很少有BSNS病例或病例系列。在本报告中,我们根据现有文献报道了我们对一例右鼻腔BSNS病例的临床治疗方法以及该疾病的组织病理学特征。
{"title":"A Rare Sinonasal Malignancy: Biphenotypic Sinonasal Sarcoma","authors":"Esra Aydın Sudabatmaz, M. A. Abakay, A. Koçbıyık, I. Sayin, Z. Yazıcı","doi":"10.4274/tao.2022.2021-11-9","DOIUrl":"https://doi.org/10.4274/tao.2022.2021-11-9","url":null,"abstract":"Biphenotypic sinonasal sarcoma (BSNS), which has been described in the recent years, is a low-grade spindle cell sinonasal sarcoma characterized by rare neural and myogenic features. It has a slow growth pattern; does not metastasize, but local recurrences are common after surgery. Non-specificity of examination findings and symptoms and similarities of its histopathological features with other spindle cell sarcomas, neural tumors, and skeletal muscle-derived tumors involving the nasal cavity make the diagnosis difficult. Therefore, histopathological features should be evaluated together with immunophenotyping and molecular studies for differential diagnosis. There are very few BSNS cases or case series in the literature. In this report, we reported our clinical approach to a case with BSNS in the right nasal cavity and the histopathological features of the disease in the light of the current literature.","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"60 1","pages":"53 - 58"},"PeriodicalIF":0.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47186873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Estimation of Serum Levels of Heavy Metals in Patients with Chronic Invasive Fungal Rhinosinusitis Before the COVID-19 Era: A Pilot Study 新冠肺炎时代前慢性侵袭性真菌性鼻炎患者血清重金属水平的初步评估
IF 0.6 Q4 OTORHINOLARYNGOLOGY Pub Date : 2022-03-01 DOI: 10.4274/tao.2022.2021-11-12
S. Kajal, J. Quadri, Prankur Verma, Ramya Thota, K. Sikka, Shivam Pandey, A. Thakar, H. Verma
Objective: Various metals play role in the survival and pathogenesis of the invasive fungal disease. The objectives of this study were to compare the levels of heavy metals in patients with chronic invasive fungal rhinosinusitis (CIFR) and healthy controls, and to analyze their role in disease outcome. Methods: Twenty-three patients (15 with invasive mucormycosis and 8 with invasive aspergillosis, Group 1), and 14 healthy controls (Group 2) were recruited. Blood samples were collected from each group into ion-free tubes and analyzed for serum levels of Nickel (Ni), Copper (Cu), Zinc (Zn), Gallium (Ga), Arsenic (As), Selenium (Se), Rubidium (Rb), Strontium (Sr), Cadmium (Cd), and Lead (Pb). The final outcome of the patients during their hospital stay was categorized clinico-radiologically as improved or worsened, or death. Results: The levels of all metals were higher in Group 1 except for As and Pb. However, the differences in Cu (p=0.0026), Ga (p=0.002), Cd (p=0.0027), and Pb (p=0.0075) levels were significant. Higher levels of Zn (p=0.009), Se (p=0.020), and Rb (p=0.016) were seen in the invasive aspergillosis subgroup. Although Zn (p=0.035), As (p=0.022), and Sr (p=0.002) levels were higher in patients with improved outcome, subgroup analysis showed no differences. Conclusion: The levels of some heavy metals in CIFR significantly differ from those of the general population and also vary with the type of the disease and its outcome. These levels may not have a direct effect on the outcome of the patient, but they do play a role in the pathogenesis of the invading fungus.
目的:各种金属在侵袭性真菌病的生存和发病机制中发挥作用。本研究的目的是比较慢性侵袭性真菌性鼻窦炎(CIFR)患者和健康对照组的重金属水平,并分析它们在疾病结果中的作用。方法:23例患者(侵袭性毛霉菌病15例,侵袭性曲霉菌病8例,第1组)和14名健康对照(第2组)被招募。将每组的血样收集到无离子管中,并分析血清中镍(Ni)、铜(Cu)、锌(Zn)、镓(Ga)、砷(As)、硒(Se)、铷(Rb)、锶(Sr)、镉(Cd)和铅(Pb)的水平。患者在住院期间的最终结果在临床放射学上被归类为改善或恶化,或死亡。结果:除As和Pb外,第1组所有金属含量均较高。然而,Cu(p=0.0026)、Ga(p=0.002)、Cd(p=0.0027)和Pb(p=0.0075)水平的差异是显著的。侵袭性曲霉菌病亚组的Zn(p=0.009)、Se(p=0.020)和Rb(p=0.016)水平较高。尽管Zn(p=0.035)、As(p=0.022)和Sr(p=0.002)水平在预后改善的患者中较高,但亚组分析显示没有差异。结论:CIFR患者的某些重金属水平与普通人群有显著差异,也因疾病类型和结果而异。这些水平可能对患者的预后没有直接影响,但它们确实在入侵真菌的发病机制中发挥了作用。
{"title":"Estimation of Serum Levels of Heavy Metals in Patients with Chronic Invasive Fungal Rhinosinusitis Before the COVID-19 Era: A Pilot Study","authors":"S. Kajal, J. Quadri, Prankur Verma, Ramya Thota, K. Sikka, Shivam Pandey, A. Thakar, H. Verma","doi":"10.4274/tao.2022.2021-11-12","DOIUrl":"https://doi.org/10.4274/tao.2022.2021-11-12","url":null,"abstract":"Objective: Various metals play role in the survival and pathogenesis of the invasive fungal disease. The objectives of this study were to compare the levels of heavy metals in patients with chronic invasive fungal rhinosinusitis (CIFR) and healthy controls, and to analyze their role in disease outcome. Methods: Twenty-three patients (15 with invasive mucormycosis and 8 with invasive aspergillosis, Group 1), and 14 healthy controls (Group 2) were recruited. Blood samples were collected from each group into ion-free tubes and analyzed for serum levels of Nickel (Ni), Copper (Cu), Zinc (Zn), Gallium (Ga), Arsenic (As), Selenium (Se), Rubidium (Rb), Strontium (Sr), Cadmium (Cd), and Lead (Pb). The final outcome of the patients during their hospital stay was categorized clinico-radiologically as improved or worsened, or death. Results: The levels of all metals were higher in Group 1 except for As and Pb. However, the differences in Cu (p=0.0026), Ga (p=0.002), Cd (p=0.0027), and Pb (p=0.0075) levels were significant. Higher levels of Zn (p=0.009), Se (p=0.020), and Rb (p=0.016) were seen in the invasive aspergillosis subgroup. Although Zn (p=0.035), As (p=0.022), and Sr (p=0.002) levels were higher in patients with improved outcome, subgroup analysis showed no differences. Conclusion: The levels of some heavy metals in CIFR significantly differ from those of the general population and also vary with the type of the disease and its outcome. These levels may not have a direct effect on the outcome of the patient, but they do play a role in the pathogenesis of the invading fungus.","PeriodicalId":44240,"journal":{"name":"Turkish Archives of Otorhinolaryngology","volume":"60 1","pages":"29 - 35"},"PeriodicalIF":0.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46518028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Turkish Archives of Otorhinolaryngology
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