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Frontal Sinus Cholesteatoma Presenting with Intracranial and Orbital Complications: Diagnosis and Treatment. 额窦胆脂瘤伴颅内及眼眶并发症:诊断及治疗。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-7-7
Débora Cristina Gaspar Gonçalves, Tiago Soares Santos, Vera Claúdia Miranda Silva, Hugo Narcy Amaral Amorim Costa, Carlos Magalhães Ferreira Carvalho

Frontal sinus keratoma or cholesteatoma is a rare disease of paranasal sinuses and presents as a slow-growing mass that becomes symptomatic as it grows to the surrounding structures. Intracranial complications are not a common presentation and are potentially life-threatening. Frequently the final diagnosis is only made intraoperatively because several other frontal sinus tumors behave likewise. Definitive treatment requires complete removal of the keratoma, and a combined endoscopic and external frontal sinus approach is a good treatment option. In this report, we presented a 68-year-old female with frontal sinus cholesteatoma with diagnostic and therapeutic features of this pathology with the review of the literature.

额窦角化瘤或胆脂瘤是一种罕见的副鼻窦疾病,表现为生长缓慢的肿块,随着其生长到周围结构而出现症状。颅内并发症并不常见,而且可能危及生命。由于其他额窦肿瘤也有类似的表现,最终的诊断往往只能在术中做出。最终的治疗需要完全切除角瘤,联合内镜和额外窦入路是一个很好的治疗选择。在这篇报告中,我们报告了一位68岁的女性额窦胆脂瘤的诊断和治疗特点,并回顾了文献。
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引用次数: 0
The Importance of Prostate-Specific Membrane Antigen Expression in Salivary Gland Tumors. 前列腺特异性膜抗原在唾液腺肿瘤表达的重要性。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-12-3
Mehmet Emre Sivrice, Hasan Yasan, Yusuf Çağdaş Kumbul, Onur Ertunç, Sarper Sayın

Objective: Prostate-specific membrane antigen (PSMA) is a cell membrane protein expressed by prostate tissues. It is not prostate specific and is also expressed by some non-prostatic solid neoplasms. Our study aimed to investigate the potential role of PSMA in salivary gland tumors.

Methods: The present study was designed to retrospectively analyze our cases that presented with salivary gland tumors. The files of 105 patients were reviewed and their paraffin embedded blocks were retrieved from the pathology department. Immunohistochemical examination and staining were done using PSMA antibody. Tumor tissue PSMA immunohistochemical staining was scored semi-quantitatively with the modified quartile approach. Negative staining was scored 0, >0% and ≤25% tissue expression was considered weak (score 1), >25% and ≤50% tissue expression was considered mild (score 2), >50% and ≤75% tissue expression was considered moderate (score 3), and >75% tissue expression was considered strong (score 4).

Results: Eighty-eight patients (55 males, 33 females) were included in the study. Forty-eight patients had pleomorphic adenoma (PA), 35 had Warthin's tumor (WT), two had mucoepidermoid carcinoma, two had adenoid cystic carcinoma, and one had squamous cell carcinoma. There was statistically significant difference in terms of PSMA expression between PA and WT (p=0.003). PSMA expression was high in PA and absent in WT.

Conclusion: PSMA is a potential source of inspiration for future studies on the development of novel diagnostic and theranostic investigations of salivary gland tumors. Prospective studies targeting intratumoral PSMA in salivary gland tumors should be planned.

目的:前列腺特异性膜抗原(PSMA)是一种由前列腺组织表达的细胞膜蛋白。它不是前列腺特异性的,也在一些非前列腺实体肿瘤中表达。我们的研究旨在探讨PSMA在唾液腺肿瘤中的潜在作用。方法:本研究旨在回顾性分析我们的涎腺肿瘤病例。我们回顾了105例患者的档案,并从病理科检索了他们的石蜡包埋块。采用PSMA抗体进行免疫组化检查和染色。采用改进的四分位数法对肿瘤组织PSMA免疫组化染色进行半定量评分。阴性染色评分为0、>0%、≤25%的组织表达为弱(评分1),>25%、≤50%的组织表达为轻度(评分2),>50%、≤75%的组织表达为中度(评分3),>75%的组织表达为强(评分4)。结果:共纳入88例患者,其中男性55例,女性33例。多形性腺瘤48例,沃辛氏瘤35例,粘液表皮样癌2例,腺样囊性癌2例,鳞状细胞癌1例。PSMA在PA组和WT组的表达差异有统计学意义(p=0.003)。结论:PSMA在唾液腺肿瘤的新诊断和治疗研究中具有潜在的启发作用。应该计划针对涎腺肿瘤肿瘤内PSMA的前瞻性研究。
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引用次数: 0
Nasal Reactivity After Radiofrequency Ablation of Peripheral Branches of Posterior Nasal Nerve. 鼻后神经外周支射频消融后的鼻反应性。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-10-1
Samy Elwany, Ziad Mandour, Ahmed Aly Ibrahim, Remon Bazak

Objective: Transection or ablation of the posterior nasal nerve (TRPN) has been described as an adjunctive tool to reduce the symptoms of intractable allergic rhinitis (AR). The procedure, however, requires surgical skill and carries the risk of bleeding from the sphenopalatine artery. The aim of the present study is to describe radiofrequency ablation of the peripheral branches of the posterior nasal nerves within the inferior turbinates (RAPN) as an effective easier alternative to TRPN.

Methods: The procedure was performed on 24 patients with intractable AR. Nasal reactivity was tested by cold dry air (CDA) provocation before and 12 months after the radiofrequency procedure. Visual analog scale and acoustic rhinometry were used to measure the changes in nasal reactivity subjectively and objectively.

Results: Worsening of nasal symptoms following CDA provocation had significantly decreased after the RAPN procedure. Likewise, postoperative decrease in nasal volumes and minimal cross-sectional areas after CDA provocation were significantly less than the corresponding preoperative values.

Conclusion: RAPN effectively reduces nasal reactivity in patients with AR. The procedure is simple, minimally invasive, and can be performed under local or general anesthesia.

目的:鼻后神经(TRPN)的横断或消融已被描述为减轻难治性变应性鼻炎(AR)症状的辅助工具。然而,该手术需要手术技巧,并且有蝶腭动脉出血的风险。本研究的目的是描述射频消融后鼻神经周围分支在下鼻甲(RAPN)作为一个有效的更容易的TRPN替代。方法:对24例难治性变应性鼻炎患者进行射频治疗,在射频治疗前和治疗后12个月用冷干空气激发法检测鼻部反应性。采用视觉模拟量表和声学鼻测量法主客观测量鼻反应性的变化。结果:经RAPN手术后,CDA诱发后鼻部症状恶化明显减少。同样,CDA激发后术后鼻体积和最小横截面积的减少也明显小于术前相应值。结论:RAPN可有效降低AR患者的鼻反应性,手术简单,微创,可在局麻或全身麻醉下进行。
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引用次数: 0
Investigation of the Relationship Between BPPV with Anxiety, Sleep Quality and Falls. BPPV与焦虑、睡眠质量和跌倒的关系研究。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-8-6
Deniz Uğur Cengiz, İsmail Demir, Sümeyye Demirel, Sanem Can Çolak, Tuğba Emekçi, Tuba Bayındır

Objective: To investigate the effects of dizziness on sleep quality and psychological status in patients with benign paroxysmal positional vertigo (BPPV) and to evaluate its relationship with falls.

Methods: A Demographic Data Form, a Visual Vertigo Analog Scale, the Falls Efficacy Scale - International (FES-I), the Hospital Anxiety and Depression Scale (HADS), and the Pittsburgh Sleep Quality Index (PSQI) were administered in 102 individuals diagnosed with BPPV by videonystagmography test. The same scales were applied to 75 healthy volunteers as the control group, and the two groups were compared. The BPPV group was divided into two groups as posterior canal and lateral canal BPPV. These two groups were compared among themselves and with the control group.

Results: A statistically significant difference was found between the BPPV and control groups, the lateral canal BPPV and posterior canal BPPV groups, the lateral canal BPPV and control groups, and the posterior canal BPPV and control groups in terms of total scores of the PSQI, the FES-I, and the HADS (p<0.001). In the regression model, the FES-I score was fully explained by the PSQI and HADS scores (p<0.001).

Conclusion: BPPV significantly affects sleep quality, psychological state, and the risk of fall. The negative effects of BPPV restrict daily living activities, affect the prognosis of the disease, and increase the risk of falling. Considering that psychiatric issues and sleep problems increase the risk of falling in individuals with BPPV, counseling services on this issue would reduce the incidence of falls and related injuries.

目的:探讨良性阵发性体位性眩晕(BPPV)患者的眩晕对睡眠质量和心理状态的影响,并探讨其与跌倒的关系。方法:采用人口统计资料表、视觉眩晕模拟量表、国际跌倒效果量表(FES-I)、医院焦虑抑郁量表(HADS)和匹兹堡睡眠质量指数(PSQI)对102例BPPV患者进行视震仪检查。将同样的量表应用于75名健康志愿者作为对照组,并对两组进行比较。BPPV组分为后管和外侧管BPPV两组。两组之间并与对照组进行比较。结果:BPPV组与对照组、外侧管BPPV组与后侧管BPPV组、外侧管BPPV组与对照组、后侧管BPPV组与对照组、后侧管BPPV组与对照组的PSQI总分、FES-I总分、HADS总分比较,差异均有统计学意义(p)。结论:BPPV显著影响睡眠质量、心理状态、跌倒风险。BPPV的负面影响限制了日常生活活动,影响疾病的预后,并增加跌倒的风险。考虑到精神问题和睡眠问题增加了BPPV患者跌倒的风险,在这个问题上的咨询服务将减少跌倒和相关伤害的发生率。
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引用次数: 0
In Memoriam: Professor İ. Nazmi Hoşal 纪念:二教授。圣诞快乐。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2023.2022-03
Umut Akyol
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引用次数: 0
A Unique Cause of Upper Airway Obstruction in a Child: Laryngeal Lipoma. 儿童上气道阻塞的独特原因:喉脂肪瘤。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-11-8
Kerem Kökoğlu, İbrahim Ketenci

There are lots of diseases causing pediatric upper airway obstruction and stridor. They can be both congenital or acquired. While congenital causes are laryngomalacia, vocal cord palsy, congenital subglottic stenosis, acquired ones range from infections to foreign bodies or neoplasms. Laryngeal neoplasms develop almost epithelial in origin. Non-epithelial tumors consist 1% of laryngeal neoplasms. Although lipoma is the most common soft tissue tumor, laryngeal involvement is very rare and seen in the ages between 40-60 years. A 13-month-old child who had laryngeal lipoma and upper airway obstruction was aimed to present in this paper.

引起小儿上呼吸道阻塞和喘鸣的疾病有很多。它们可以是先天性的,也可以是后天的。先天性原因有喉软化症、声带麻痹、先天性声门下狭窄,而后天原因则有感染、异物或肿瘤。喉部肿瘤几乎起源于上皮细胞。非上皮性肿瘤占喉部肿瘤的1%。虽然脂肪瘤是最常见的软组织肿瘤,但累及喉部是非常罕见的,见于40-60岁之间。一个13个月大的孩子谁有喉部脂肪瘤和上气道阻塞的目的是提出在这篇文章。
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引用次数: 0
The Elderly Voice: Mechanisms, Disorders and Treatment Methods. 老年人的声音:机制、障碍和治疗方法。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-8-1
Süha Beton, Levent Yücel, Hazan Başak, Zahide Çiler Büyükatalay

The elderly population is increasing globally. In Turkey, the population aged 65+ is predicted to grow to more than 15% of the whole population by 2050. Just like the rest of the body, the voice also changes with age. Voice changes throughout life have been reported in up to 52.4% of aged individuals and may have a negative impact on their quality of life. Voice is affected by various factors, including age, disease, hormones, medications, and physiological, psychological, and social conditions. A multidisciplinary approach is therefore needed to achieve the best voice outcomes. In this review, we summarize the mechanisms involved in voice changes in the elderly together with the applicable diagnostic and treatment methods.

全球老年人口正在增加。在土耳其,预计到2050年,65岁以上的人口将增长到总人口的15%以上。就像身体的其他部分一样,声音也会随着年龄的增长而变化。据报道,多达52.4%的老年人一生中都有声音变化,这可能对他们的生活质量产生负面影响。声音受到各种因素的影响,包括年龄、疾病、激素、药物以及生理、心理和社会条件。因此,需要多学科的方法来实现最佳的语音结果。本文就老年人嗓音变化的发生机制及相应的诊断和治疗方法进行综述。
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引用次数: 0
Factors Affecting Permanent Sensorineural Hearing Loss and Bone Conduction in Patients After Receiving Radiotherapy to the Head and Neck Region. 影响头颈部放疗后永久性感音神经性听力损失及骨传导的因素。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-6-2
Birsen Yücel, Eda Erdiş, Seher Bahar, Ebru Akkaş Atasever, Mustafa Gürol Celasun, Emine Elif Altuntaş

Objective: This study aimed to investigate the factors affecting permanent sensorineural hearing loss (SNHL) and causing changes in bone conduction (BC) thresholds over time in patients after receiving radiotherapy (RT) or chemoradiotherapy (CRT) to the head and neck region.

Methods: A total of 63 patients with irradiated HNC that were admitted to the Radiation Oncology Department between 2011 and 2018 were included in the study. All patients were assessed with pure tone audiometry at eight different time points (first before RT and last five years after completion of RT). A chi-square test was used to analyze the variables that affected permanent SNHL occurrence. Repeated measure analysis of variance was conducted to investigate the factors affecting change in the BC threshold at pure-tone average (0.5-2 kHz) and the air conduction (AC) threshold at 4 and 6 kHz frequencies over time.

Results: Median follow-up was 52 months (range, 12-110 months). SNHL was found in 18 (14%) of the 126 ears. According to the receiver operating characteristic analysis, the cut-off values of cochlear Dmean and Dmax radiation doses were 40 Gy [p=0.017, area under the curve (AUC): 0.676] and 45 Gy (p=0.008, AUC: 0.695). Dmean (≤40 Gy vs. >40 Gy) and Dmax (≤45 Gy vs. >45 Gy) cochlear doses and age (≤40 vs. >40 years) were determined as factors affecting SNHL in the chi-square test. Repeated measures showed that BC thresholds between 0.5-2 kHz and AC thresholds at 4 and 6 kHz increased over time. Age (≤40 vs. >40 years), treatment of head and neck cancer (RT vs. CRT), cisplatin use, and Dmean (≤40 Gy vs. >40 Gy) and Dmax cochlear dose (≤45 Gy vs. >45 Gy) were important factors affecting the course of BC threshold over time.

Conclusion: Dmean and Dmax cochlear doses and age were found to be associated with permanent SNHL. Conduction thresholds worsened over time at all frequencies, and this trend was affected by cochlear doses, age, CRT, and cisplatin use.

目的:本研究旨在探讨影响永久性感音神经性听力损失(SNHL)的因素,以及头颈部放疗(RT)或放化疗(CRT)后患者骨传导(BC)阈值随时间变化的因素。方法:选取2011 - 2018年在放射肿瘤科收治的63例经放疗的HNC患者作为研究对象。所有患者在8个不同的时间点(第一次放疗前和最后5年完成放疗后)用纯音听力学进行评估。采用卡方检验分析影响永久性SNHL发生的变量。通过重复测量方差分析,探讨影响纯音平均(0.5-2 kHz)下BC阈值和4、6 kHz下空气传导(AC)阈值随时间变化的因素。结果:中位随访时间为52个月(范围12-110个月)。126只耳中有18只(14%)发现SNHL。根据受试者工作特征分析,耳蜗Dmean和Dmax辐射剂量的临界值分别为40 Gy和45 Gy [p=0.017,曲线下面积(AUC): 0.676]和45 Gy (p=0.008, AUC: 0.695)。通过卡方检验确定影响SNHL的因素为Dmean(≤40 Gy vs >40 Gy)和Dmax(≤45 Gy vs >45 Gy)耳蜗剂量和年龄(≤40 Gy vs >40岁)。反复测量表明,0.5-2 kHz之间的BC阈值和4和6 kHz之间的AC阈值随着时间的推移而增加。年龄(≤40岁vs >40岁)、头颈癌治疗(RT vs CRT)、顺铂使用、Dmean(≤40 Gy vs >40 Gy)和Dmax耳耳剂量(≤45 Gy vs >45 Gy)是影响BC阈值随时间变化的重要因素。结论:Dmean和Dmax耳蜗剂量和年龄与永久性SNHL有关。传导阈值随时间的推移而恶化,这种趋势受耳蜗剂量、年龄、CRT和顺铂使用的影响。
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引用次数: 0
Evaluation of the Effect of Musical Perception Activities on Speech Perception in Adult Cochlear Implant Users. 成人人工耳蜗使用者音乐知觉活动对言语知觉影响的评价。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-8-3
Başak Mutlu, Merve Torun Topçu, Mustafa Yüksel, Mahmut Tayyar Kalcıoğlu

Objective: This study aimed to evaluate clinical musical perception, analyze the relationship between speech recognition and music perception, and investigate the effects of a three-month musical perception activities on these parameters in adult cochlear implant (CI) users with post-lingual hearing loss.

Methods: Free-field hearing and speech tests in a quiet environment, the Turkish matrix test, and the Turkish version of the clinical assessment of musical perception test were performed on 18 adult unilateral CI users before and after the three-month music training. Results were compared with those of 18 healthy controls.

Results: Prior to the musical perception activities, word recognition scores, Turkish matrix test results, and 500, 1000, and 6000 Hz free-field hearing thresholds were significantly correlated with the clinical assessment of musical perception test scores in the CI group (p<0.047). Timbre recognition scores (p=0.019) had improved significantly in the CI group after the three-month musical perception activities. On the other hand, timbre recognition scores had significantly affected the Turkish matrix test results (R2adjusted=0.56).

Conclusion: Our study showed that speech perception in noise and clinical musical perception measurements affected each other in CI users. The inclusion of musical perception activities to support an auditory rehabilitation program may contribute to increased speech recognition skills in noise.

目的:评价语后听力损失成人人工耳蜗(CI)使用者的临床音乐感知能力,分析语音识别与音乐感知的关系,并探讨三个月的音乐感知活动对这些参数的影响。方法:对18例成人单侧CI使用者进行为期3个月的音乐训练前后的安静环境下自由场听力言语测试、土耳其矩阵测试和土耳其版音乐感知临床评估测试。结果与18名健康对照进行比较。结果:在音乐感知活动开始前,词识别分数、土耳其矩阵测试结果和500、1000和6000 Hz自由场听力阈值与CI组音乐感知测试分数的临床评估显著相关(p)。结论:我们的研究表明,CI用户在噪音和临床音乐感知测量中的语音感知相互影响。包括音乐感知活动,以支持听觉康复计划可能有助于提高在噪音中的语音识别技能。
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引用次数: 0
A Rare Incidental Diagnosis After Adenoidectomy: Sarcoidosis. 腺样体切除术后罕见的意外诊断:结节病。
IF 0.6 Pub Date : 2022-12-01 DOI: 10.4274/tao.2022.2022-10-11
Mehmet Emre Sivrice, Vural Akın, Mustafa Doğan

Sarcoidosis is a systemic disease of unknown etiology. It is characterized by non-caseating granulomatous inflammation. It most commonly affects the pulmonary and intrathoracic lymph nodes. Isolated nasopharyngeal involvement is very rare. Pediatric sarcoidosis and isolated nasopharyngeal involvement are rare entities. Symptoms of nasopharyngeal involvement can mimic adenoid hypertrophy. In this case report, we present a nine-year-old female who was diagnosed coincidentally with sarcoidosis with the adenoidectomy specimen.

结节病是一种病因不明的全身性疾病。它以非干酪化肉芽肿性炎症为特征。它最常影响肺和胸内淋巴结。孤立的鼻咽部受累是非常罕见的。小儿结节病和孤立的鼻咽部受累是罕见的。鼻咽部受累的症状可模仿腺样体肥大。在这个病例报告中,我们报告了一个9岁的女孩,她被诊断为结节病和腺样体切除术标本。
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引用次数: 0
期刊
Turkish Archives of Otorhinolaryngology
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