Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.042
Shikha Chopra
Calcifying fibrous tumor (CFT) is benign mesenchymal lesion. CFTs of the GI tract are quite rare with less than 60 cases of gastric CFTs reported in the English literature. In a healthy 49 old female, routine Endoscopic ultrasonography (EUS) revealed an internally isoechoic, homogeneous 12mm lesion mainly within the submucosa in the distal body of stomach with no significant past history. An endoscopic submucosal dissection (ESD) was done to rule out malignancy. The histopathological examination showed a hypocellular lesion with few spindle cells interspersed in a hyalinized, collagenous matrix with occasional lymphoplasmacytic cells. Foci of psammomatous, dystrophic calcification were noted. Immunohistochemical examination revealed tumor cells positive for vimentin and negative for CD34, CD117, DOG1, desmin, SMA and S100. Based on histopathological and IHC findings, a diagnosis of gastric calcifying fibrous tumour was made. Only a handful of CFT cases resected by endoscopic submucosal dissection has been reported in the literature. So herein we report a rare case of endoscopically resected gastric calcifying fibrous tumor.
{"title":"Endoscopic resection of gastric calcifying fibrous tumor: An incidental finding","authors":"Shikha Chopra","doi":"10.18231/j.ijpo.2023.042","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.042","url":null,"abstract":"Calcifying fibrous tumor (CFT) is benign mesenchymal lesion. CFTs of the GI tract are quite rare with less than 60 cases of gastric CFTs reported in the English literature. In a healthy 49 old female, routine Endoscopic ultrasonography (EUS) revealed an internally isoechoic, homogeneous 12mm lesion mainly within the submucosa in the distal body of stomach with no significant past history. An endoscopic submucosal dissection (ESD) was done to rule out malignancy. The histopathological examination showed a hypocellular lesion with few spindle cells interspersed in a hyalinized, collagenous matrix with occasional lymphoplasmacytic cells. Foci of psammomatous, dystrophic calcification were noted. Immunohistochemical examination revealed tumor cells positive for vimentin and negative for CD34, CD117, DOG1, desmin, SMA and S100. Based on histopathological and IHC findings, a diagnosis of gastric calcifying fibrous tumour was made. Only a handful of CFT cases resected by endoscopic submucosal dissection has been reported in the literature. So herein we report a rare case of endoscopically resected gastric calcifying fibrous tumor.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122649609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.046
Mauli G. Joshi, Sandeep Sheth, M. Patel, Priyanka Chiripal, L. Parikh
The WHO categorizes the breast tumors in various distinct histological types based on cell morphology and architecture. A widely accepted fact that the aggressive nature of the breast cancer can be determined by its histological type, grade, nodal status, and metastasis holds the ground even in the era of immunohistochemistry (IHC) and molecular. An extremely rare variant of primary breast carcinoma belongs to the family of mucin producing carcinoma sharing the same histology as the mucinous cystadenocarcinoma of the ovary and pancreas. The tumour typically occurs in postmenopausal women with a median patient age of 61 years. Due to the rarity of these tumors, there is an extreme paucity of literature on this topic. We report a case of 35 year old female with left breast lump and presternal swelling. Breast lumpectomy and total sternectomy was done and final diagnosis was given as Primary mucinous cystadenocarcinoma with sternal metastasis and Estrogen receptor (ER) and Progesterone receptors (PR) positivity.
{"title":"Primary mucinous cystadenocarcinoma of breast with sternal metastasis: A diagnostic challange","authors":"Mauli G. Joshi, Sandeep Sheth, M. Patel, Priyanka Chiripal, L. Parikh","doi":"10.18231/j.ijpo.2023.046","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.046","url":null,"abstract":"The WHO categorizes the breast tumors in various distinct histological types based on cell morphology and architecture. A widely accepted fact that the aggressive nature of the breast cancer can be determined by its histological type, grade, nodal status, and metastasis holds the ground even in the era of immunohistochemistry (IHC) and molecular. An extremely rare variant of primary breast carcinoma belongs to the family of mucin producing carcinoma sharing the same histology as the mucinous cystadenocarcinoma of the ovary and pancreas. The tumour typically occurs in postmenopausal women with a median patient age of 61 years. Due to the rarity of these tumors, there is an extreme paucity of literature on this topic. We report a case of 35 year old female with left breast lump and presternal swelling. Breast lumpectomy and total sternectomy was done and final diagnosis was given as Primary mucinous cystadenocarcinoma with sternal metastasis and Estrogen receptor (ER) and Progesterone receptors (PR) positivity.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129031291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.043
Mukilarasi K R, Kavita V
Collision tumors are rare neoplasms defined by the presence of two distant tumors in the same organ without any histological intermixing. Each component of the collision tumor occur coincidently and no connection is found between the tumors. Our case is a collision tumor of ovary composed of mature cystic teratoma and Mucinous cystadenoma.
{"title":"Collision tumor of ovary – Case report","authors":"Mukilarasi K R, Kavita V","doi":"10.18231/j.ijpo.2023.043","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.043","url":null,"abstract":"Collision tumors are rare neoplasms defined by the presence of two distant tumors in the same organ without any histological intermixing. Each component of the collision tumor occur coincidently and no connection is found between the tumors. Our case is a collision tumor of ovary composed of mature cystic teratoma and Mucinous cystadenoma.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114522590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.026
B. Sonwane, Prajakta D Gonjari, S. Anjum, Anil R Joshi
Albrecht introduced the concept of hamartoma at the beginning of twentieth century to designate a tumor like or non-neoplastic malformation or inborn error of tissue development. They arise virtually in all organs. They may derive from any three germinal layer of which mesodermal derived overgrowth is most common. They are slow growing and have self-limited growth. The formation of these growth take place by abnormal mixing of tissue in course of development. Present retrospective study was conducted in pathology department over a period of 2 years from July 2020 to June 2022. Total twenty cases were included in study and it was observed that twelve cases occurred in head and neck region, one case occurred over chest, one case in gastrointestinal tract and six cases in extremities. It is important to differentiate hamartomas from related lesions like choristoma, teratoma and benign tumors to avoid aggressive treatment.
{"title":"Study of hamartomatous lesions along with its fatality with review of literature","authors":"B. Sonwane, Prajakta D Gonjari, S. Anjum, Anil R Joshi","doi":"10.18231/j.ijpo.2023.026","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.026","url":null,"abstract":"Albrecht introduced the concept of hamartoma at the beginning of twentieth century to designate a tumor like or non-neoplastic malformation or inborn error of tissue development. They arise virtually in all organs. They may derive from any three germinal layer of which mesodermal derived overgrowth is most common. They are slow growing and have self-limited growth. The formation of these growth take place by abnormal mixing of tissue in course of development. Present retrospective study was conducted in pathology department over a period of 2 years from July 2020 to June 2022. Total twenty cases were included in study and it was observed that twelve cases occurred in head and neck region, one case occurred over chest, one case in gastrointestinal tract and six cases in extremities. It is important to differentiate hamartomas from related lesions like choristoma, teratoma and benign tumors to avoid aggressive treatment.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132610935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.037
Anjali Ahalawat, R. Verma, R. Kalra, Pinki Tomer, Sunita Singh
Idiopathic pleuroparenchymal fibroelastosis is a rare idiopathic interstitial pneumonia which mainly affects the upper lobe of lungs resulting in intra alveolar fibrosis, elastosis and visceral pleural fibrosis. For definite diagnosis, radiographic findings as well as histopathology findings are required. The overlap with interstitial lung diseases seen usually, makes it challenging to diagnose. There are no guidelines available for the diagnosis and appropriate management of this disease and only a few cases reported in the literature. We report a case of pleuroparenchymal fibroelastosis in autopsy in a 32-year-old female who allegedly died of heart failure with review of literature.
{"title":"Autopsy findings in a case of idiopathic pleuroparenchymal fibroelastosis: A rare entity with review of literature","authors":"Anjali Ahalawat, R. Verma, R. Kalra, Pinki Tomer, Sunita Singh","doi":"10.18231/j.ijpo.2023.037","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.037","url":null,"abstract":"Idiopathic pleuroparenchymal fibroelastosis is a rare idiopathic interstitial pneumonia which mainly affects the upper lobe of lungs resulting in intra alveolar fibrosis, elastosis and visceral pleural fibrosis. For definite diagnosis, radiographic findings as well as histopathology findings are required. The overlap with interstitial lung diseases seen usually, makes it challenging to diagnose. There are no guidelines available for the diagnosis and appropriate management of this disease and only a few cases reported in the literature. We report a case of pleuroparenchymal fibroelastosis in autopsy in a 32-year-old female who allegedly died of heart failure with review of literature.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123701777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.035
Dipanjan Panda, Disha Tiwari, Atul Sharma, D. Kishan
Chemotherapy-induced peripheral neuropathy (CIPN) is a well-documented toxicity leading to dose limitation.Ibrutinib is an oral Bruton’s Tyrosine Kinase (BTK) inhibitor approved for treating chronic lymphocytic lymphoma. The most common neurological side effects of Ibrutinib include headache and dizziness. Herein, we report peripheral neuropathy as a dose-limiting manifestation of Ibrutinib treatment.
{"title":"Ibrutinib induced sensorimotor neuropathy: A novel side effect","authors":"Dipanjan Panda, Disha Tiwari, Atul Sharma, D. Kishan","doi":"10.18231/j.ijpo.2023.035","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.035","url":null,"abstract":"Chemotherapy-induced peripheral neuropathy (CIPN) is a well-documented toxicity leading to dose limitation.Ibrutinib is an oral Bruton’s Tyrosine Kinase (BTK) inhibitor approved for treating chronic lymphocytic lymphoma. The most common neurological side effects of Ibrutinib include headache and dizziness. Herein, we report peripheral neuropathy as a dose-limiting manifestation of Ibrutinib treatment.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126513328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.047
M. Hassan, Saqib Ahmed, Murad Ahmad, S. Arif, Bushra Siddiqui
Sebaceous carcinoma is a rare locally aggressive neoplasm of the sebaceous gland, which occurs frequently in elderly males. It constitutes 0.2 to 4.6% of all the malignant cutaneous tumours and occurs commonly in the periocular area. Scalp is a rare site for this tumor. Here we report a case of sebaceous carcinoma in a young 28 years old male patient who presented with firm to hard exophytic growth over right posterior occipital region with enlarged suboccipital and post auricular lymph nodes. Wide local excision was done and a diagnosis of sebaceous carcinoma of the scalp with lymph node metastasis was rendered after histopathological and Immunohistochemical examination.
{"title":"Sebaceous cell carcinoma of the scalp in a young male: A rare case report","authors":"M. Hassan, Saqib Ahmed, Murad Ahmad, S. Arif, Bushra Siddiqui","doi":"10.18231/j.ijpo.2023.047","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.047","url":null,"abstract":"Sebaceous carcinoma is a rare locally aggressive neoplasm of the sebaceous gland, which occurs frequently in elderly males. It constitutes 0.2 to 4.6% of all the malignant cutaneous tumours and occurs commonly in the periocular area. Scalp is a rare site for this tumor. Here we report a case of sebaceous carcinoma in a young 28 years old male patient who presented with firm to hard exophytic growth over right posterior occipital region with enlarged suboccipital and post auricular lymph nodes. Wide local excision was done and a diagnosis of sebaceous carcinoma of the scalp with lymph node metastasis was rendered after histopathological and Immunohistochemical examination.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"515 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123895229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.048
Anusha Thangaraja, V. Ramaswamy
{"title":"Simplified molecular classification of gastric adenocarcinoma: Enhanced perspectives","authors":"Anusha Thangaraja, V. Ramaswamy","doi":"10.18231/j.ijpo.2023.048","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.048","url":null,"abstract":"","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115294792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.036
Akanksha Hegde, V. Mysorekar
Synovial sarcoma (SS) is a rare type of high-grade soft tissue sarcoma that accounts for 5% to 10% of all soft tissue tumors. It primarily affects the soft tissue of the arms and legs. The rate of lymph node metastases in synovial sarcoma is 3% to 7%.They are locally aggressive and have a higher metastatic potential. The overall prognosis of patients is poor due to systemic metastasis. Immunohistochemistry and molecular studies are indispensable in the diagnosis of these tumors.We present to you a case of biphasic synovial sarcoma of left thigh in a 70-year-old lady with lymph node metastasis and squamous differentiation.
{"title":"Biphasic synovial sarcoma with squamous differentiation in the thigh – A case report","authors":"Akanksha Hegde, V. Mysorekar","doi":"10.18231/j.ijpo.2023.036","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.036","url":null,"abstract":"Synovial sarcoma (SS) is a rare type of high-grade soft tissue sarcoma that accounts for 5% to 10% of all soft tissue tumors. It primarily affects the soft tissue of the arms and legs. The rate of lymph node metastases in synovial sarcoma is 3% to 7%.They are locally aggressive and have a higher metastatic potential. The overall prognosis of patients is poor due to systemic metastasis. Immunohistochemistry and molecular studies are indispensable in the diagnosis of these tumors.We present to you a case of biphasic synovial sarcoma of left thigh in a 70-year-old lady with lymph node metastasis and squamous differentiation.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115688639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.032
Durgesh Kumar Dhakar, N. Rai
: The red blood cell (RBC) parameters generated by cell counters can aid in morphological categorization of anemia, the significance of microscopic analysis of peripheral blood smears (PBSs) cannot be overlooked when it comes to interpreting the underlying cause of anemia. Therefore, both RBC parameters and microscopic examination of PBSs are essential for a comprehensive assessment of anemia.This study aimed to evaluate and compare the results obtained through two different methods: examination of peripheral blood smears (PBS) and automated cell counter generated parameters. The objective was to identify any differences or similarities in the diagnostic outcomes produced by each method. Over the course of one year, from December 2020 to November 2021, a hospital-based, prospective study was conducted. The study aimed to evaluate and compare the PBS findings and RBC parameters and histograms generated by a cell counter in 1000 anemic patients.In a sample of 1000 cases, we compared the typing of anemia using an automated analyzer and peripheral smear examination. Out of these cases, 690 showed consistent typing results between the two methods, while 310 showed discordant typing. The automated analyzer diagnosed majority of cases 70.1% as microcytic anemia and Normocytic, dimorphic, and macrocytic cases were found in 13.5%, 7.8%, and 4.3% of cases, respectively. Additionally, a normal histogram was observed in 17.6% of cases.We have concluded that while the automated analyzer is useful in reducing the overall workload through its graphical representation of anemia typing, it should always be confirmed through microscopy. The automated analyzer is a helpful tool, it should not be relied upon solely for accurate anemia typing. Microscopy remains an essential method for confirming the results of automated analysis.
{"title":"A comparative study of red cell histogram along with CBC parameters and peripheral blood smear in various anemias","authors":"Durgesh Kumar Dhakar, N. Rai","doi":"10.18231/j.ijpo.2023.032","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.032","url":null,"abstract":": The red blood cell (RBC) parameters generated by cell counters can aid in morphological categorization of anemia, the significance of microscopic analysis of peripheral blood smears (PBSs) cannot be overlooked when it comes to interpreting the underlying cause of anemia. Therefore, both RBC parameters and microscopic examination of PBSs are essential for a comprehensive assessment of anemia.This study aimed to evaluate and compare the results obtained through two different methods: examination of peripheral blood smears (PBS) and automated cell counter generated parameters. The objective was to identify any differences or similarities in the diagnostic outcomes produced by each method. Over the course of one year, from December 2020 to November 2021, a hospital-based, prospective study was conducted. The study aimed to evaluate and compare the PBS findings and RBC parameters and histograms generated by a cell counter in 1000 anemic patients.In a sample of 1000 cases, we compared the typing of anemia using an automated analyzer and peripheral smear examination. Out of these cases, 690 showed consistent typing results between the two methods, while 310 showed discordant typing. The automated analyzer diagnosed majority of cases 70.1% as microcytic anemia and Normocytic, dimorphic, and macrocytic cases were found in 13.5%, 7.8%, and 4.3% of cases, respectively. Additionally, a normal histogram was observed in 17.6% of cases.We have concluded that while the automated analyzer is useful in reducing the overall workload through its graphical representation of anemia typing, it should always be confirmed through microscopy. The automated analyzer is a helpful tool, it should not be relied upon solely for accurate anemia typing. Microscopy remains an essential method for confirming the results of automated analysis.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125355042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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