Pub Date : 2023-09-06DOI: 10.22376/ijlpr.2023.13.6.l227-l234
K. Manik, Sheela Joice P P, Jithesh T K, Imran A Jagadal, Sudhindra Prathap. A, Basheer M P
Metabolic syndrome (MS) increases cardiovascular disease and death risk. Many studies have found a link between vascular inflammation and metabolic disorders. Discovering unique and specific blood-based indicators for vascular inflammation, particularly in metabolic syndrome related to obesity, such as (lipoprotein-associated phospholipase A2) and Lp-PLA2, could provide valuable assistance in identifying individuals at an elevated risk for cardiovascular incidents. Lp-PLA2 has been implicated in metabolic dysregulation, playing a crucial role in the onset of microvascular dysfunction and the exacerbation of oxidative stress. Lp-PLA2 is essential in the pathogenesis of atherosclerosis and may be used as a biomarker to predict future cardiovascular events. The study comprised 200 participants categorized into two groups: individuals diagnosed with MS (Metabolic Syndrome) (Test, n = 100) and those without MS (controls, n = 100). The serum activity levels of hs-CRP and Lp-PLA2 were measured and subsequently analysed for correlation with micronutrients (magnesium (Mg) and zinc (Zn)) and lipoprotein markers (Ox LDL, Apo-A1, and Apo-B). The study showed a significant correlation between Lp-PLA2 and the Mg level of patients with MS, whereas Hs-CRP did not exhibit a significant correlation. The test population did not exhibit a noteworthy elevation in oxidized LDL level, despite the presence of inflammatory changes as indicated by the level of Lp-PLA2. A significant correlation was observed between the Zn level in patients with MS and Lp-PLA2, whereas Ox LDL did not exhibit a significant correlation. The current study revealed a significant link between Mg and Zn and CVD risk in the Kerala population. The study found elevated levels of LpPLA2, an emerging biomarker for cardiovascular risk, in people with MS
{"title":"Correlation Between Serum Magnesium & Zinc with Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) In Patients with Metabolic Syndrome","authors":"K. Manik, Sheela Joice P P, Jithesh T K, Imran A Jagadal, Sudhindra Prathap. A, Basheer M P","doi":"10.22376/ijlpr.2023.13.6.l227-l234","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.6.l227-l234","url":null,"abstract":"Metabolic syndrome (MS) increases cardiovascular disease and death risk. Many studies have found a link between vascular inflammation and metabolic disorders. Discovering unique and specific blood-based indicators for vascular inflammation, particularly in metabolic syndrome related to obesity, such as (lipoprotein-associated phospholipase A2) and Lp-PLA2, could provide valuable assistance in identifying individuals at an elevated risk for cardiovascular incidents. Lp-PLA2 has been implicated in metabolic dysregulation, playing a crucial role in the onset of microvascular dysfunction and the exacerbation of oxidative stress. Lp-PLA2 is essential in the pathogenesis of atherosclerosis and may be used as a biomarker to predict future cardiovascular events. The study comprised 200 participants categorized into two groups: individuals diagnosed with MS (Metabolic Syndrome) (Test, n = 100) and those without MS (controls, n = 100). The serum activity levels of hs-CRP and Lp-PLA2 were measured and subsequently analysed for correlation with micronutrients (magnesium (Mg) and zinc (Zn)) and lipoprotein markers (Ox LDL, Apo-A1, and Apo-B). The study showed a significant correlation between Lp-PLA2 and the Mg level of patients with MS, whereas Hs-CRP did not exhibit a significant correlation. The test population did not exhibit a noteworthy elevation in oxidized LDL level, despite the presence of inflammatory changes as indicated by the level of Lp-PLA2. A significant correlation was observed between the Zn level in patients with MS and Lp-PLA2, whereas Ox LDL did not exhibit a significant correlation. The current study revealed a significant link between Mg and Zn and CVD risk in the Kerala population. The study found elevated levels of LpPLA2, an emerging biomarker for cardiovascular risk, in people with MS","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41765885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.22376/ijlpr.2023.13.5.l349-l356
K. Muthulakshmi, D. Monesh, Srilakshmi Moses, J. Aunselvi, Bernard Ebenezer Cyrus, Thirulogachandar Gunasekar, Rakshana. V.S.
Primary dysmenorrhea is pain aggravation on menstruation without any pelvic disease. It is perhaps the most widely recognizedissue females face, influencing them physically and mentally. Connective tissue mobilization can help venous return by increasing theproduction of prostaglandin and different substances and preventing their collection in the pelvis, which can be powerful during the period,to reduce the pain aggravation and inconvenience. This study examines the effects of connective tissue mobilization vs. a combination oftaping and pelvic tilt on unmarried women with primary dysmenorrhea. This is an experimental design with pre and post-comparativestudy. This was conducted in the physiotherapy outpatient department at ACS Medical College and Hospital. The study duration was about3 months. The subjects aged 18 to 25 years female with primary dysmenorrheal were included in this study. The subject with Pelvicinflammatory disease, Uterine/ovarian tumor, Spinal pathology, deformity, and PCOD, were excluded from this study. 30 subjects wereselected and divided into 2 groups in which Group-A 15 received connective tissue mobilization for 3-4 minutes with a total of 20minutes/day a day before menstruation for 3 days for consecutive 3 months, and Group B received taping with pelvic tilt was given 4 daysfor lower abdomen and lumbar, one day before menstruation taping was applied and pelvic tilt was given 2-3 minutes for 20 minutes/dayfor 3 consecutive months The outcome measures were a pain. The outcome tools were the Menstrual symptom questionnaire, Numericalrating scale, and WaLIDD score. Comparing the pretest and posttest within Group A and Group B, Group B shows a highly significantdifference in Mean values at P <_0.001. Thus this study concludes that a combination of taping and pelvic tilt reduces pain in unmarriedwomen having primary Dysmenorrhea.
{"title":"Connective Tissue Mobilization Vs. Combination of Taping with Pelvic Tilt on Primary Dysmenorrhea.","authors":"K. Muthulakshmi, D. Monesh, Srilakshmi Moses, J. Aunselvi, Bernard Ebenezer Cyrus, Thirulogachandar Gunasekar, Rakshana. V.S.","doi":"10.22376/ijlpr.2023.13.5.l349-l356","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l349-l356","url":null,"abstract":"Primary dysmenorrhea is pain aggravation on menstruation without any pelvic disease. It is perhaps the most widely recognizedissue females face, influencing them physically and mentally. Connective tissue mobilization can help venous return by increasing theproduction of prostaglandin and different substances and preventing their collection in the pelvis, which can be powerful during the period,to reduce the pain aggravation and inconvenience. This study examines the effects of connective tissue mobilization vs. a combination oftaping and pelvic tilt on unmarried women with primary dysmenorrhea. This is an experimental design with pre and post-comparativestudy. This was conducted in the physiotherapy outpatient department at ACS Medical College and Hospital. The study duration was about3 months. The subjects aged 18 to 25 years female with primary dysmenorrheal were included in this study. The subject with Pelvicinflammatory disease, Uterine/ovarian tumor, Spinal pathology, deformity, and PCOD, were excluded from this study. 30 subjects wereselected and divided into 2 groups in which Group-A 15 received connective tissue mobilization for 3-4 minutes with a total of 20minutes/day a day before menstruation for 3 days for consecutive 3 months, and Group B received taping with pelvic tilt was given 4 daysfor lower abdomen and lumbar, one day before menstruation taping was applied and pelvic tilt was given 2-3 minutes for 20 minutes/dayfor 3 consecutive months The outcome measures were a pain. The outcome tools were the Menstrual symptom questionnaire, Numericalrating scale, and WaLIDD score. Comparing the pretest and posttest within Group A and Group B, Group B shows a highly significantdifference in Mean values at P <_0.001. Thus this study concludes that a combination of taping and pelvic tilt reduces pain in unmarriedwomen having primary Dysmenorrhea.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"176 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.22376/ijlpr.2023.13.5.l340-l348
Dr. Preeti S. Borkar, Dr.Sushil Yanpallewar, Dr.Pratyendra Pal Singh, Dr. Akshay Pargaonkar, Dr.Rhushikesh Thakre
Aushadh Sevan Kaal is a concept described in Ayurved samhitas, which means the time of medicine administration.Kaal(Time) isincluded in karana dravya and plays many important roles in our lives. The existence of the Kaal is from the Shrishti Uttpatti.Aacharya charak hasdescribed Trisutra Ayurved, which explains the knowledge about the entire Ayurveda.Trisutra includes Hetu[causative factors], Linga[signs andsymptoms], and Aushadh [medicines]. Additional considerations listed by Acharya Charaka include the patient's desha (region), kala (time),pramana (dosage), satmya (wholesomeness), asatmya (unwholesomeness), aahara (diet), and aushadh (medicine). Kaal is a particular and distinctcause of all kinds of outcomes and is also inevitable. Ayurveda is the science of life, emphasizing the idea of kaal as it is one of the karan dravya.The present study aims to critically analyze different terms used in samhitas for nomenclature and terminologies related to the administration time(aushadh sevan kaal) of ayurvedic herbo mineral formulations. To achieve this, we aim to study the concept of aushadha sevan kaal in varioussamhitas for its utility in identifying textual study material for selecting the treatment protocol. There are differences in the nomenclature[terminologies] in various samhitas and their commentaries. Mild variation is also observed in the number of types of Aushadh sevan kaal as perSamhitas. All Ayurveda treatments concentrate on maintaining and retaining the power of agni because it is the primary factor in establishing theDhatu Samyata.In the current era, it is observed that proper medicine administration needs to be done in relationship with Dosha,dusya,rogi, androgbala in consideration of the aushadh seven kaal. Hence, treatment is not successful in treating the patients.In this study, it is observed thatdifferent terms are mentioned in Ayurveda texts for different types of Aushadh sevan Kaal by different-different Acharyas.
{"title":"Nomenclature of Aushadh Sevan Kaal(Time of Drug Administration) In Various Ayurved Samhita’s and Its Commentaries- A Critical Review","authors":"Dr. Preeti S. Borkar, Dr.Sushil Yanpallewar, Dr.Pratyendra Pal Singh, Dr. Akshay Pargaonkar, Dr.Rhushikesh Thakre","doi":"10.22376/ijlpr.2023.13.5.l340-l348","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l340-l348","url":null,"abstract":"Aushadh Sevan Kaal is a concept described in Ayurved samhitas, which means the time of medicine administration.Kaal(Time) isincluded in karana dravya and plays many important roles in our lives. The existence of the Kaal is from the Shrishti Uttpatti.Aacharya charak hasdescribed Trisutra Ayurved, which explains the knowledge about the entire Ayurveda.Trisutra includes Hetu[causative factors], Linga[signs andsymptoms], and Aushadh [medicines]. Additional considerations listed by Acharya Charaka include the patient's desha (region), kala (time),pramana (dosage), satmya (wholesomeness), asatmya (unwholesomeness), aahara (diet), and aushadh (medicine). Kaal is a particular and distinctcause of all kinds of outcomes and is also inevitable. Ayurveda is the science of life, emphasizing the idea of kaal as it is one of the karan dravya.The present study aims to critically analyze different terms used in samhitas for nomenclature and terminologies related to the administration time(aushadh sevan kaal) of ayurvedic herbo mineral formulations. To achieve this, we aim to study the concept of aushadha sevan kaal in varioussamhitas for its utility in identifying textual study material for selecting the treatment protocol. There are differences in the nomenclature[terminologies] in various samhitas and their commentaries. Mild variation is also observed in the number of types of Aushadh sevan kaal as perSamhitas. All Ayurveda treatments concentrate on maintaining and retaining the power of agni because it is the primary factor in establishing theDhatu Samyata.In the current era, it is observed that proper medicine administration needs to be done in relationship with Dosha,dusya,rogi, androgbala in consideration of the aushadh seven kaal. Hence, treatment is not successful in treating the patients.In this study, it is observed thatdifferent terms are mentioned in Ayurveda texts for different types of Aushadh sevan Kaal by different-different Acharyas.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135298595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the XXI century, the interest and demand for natural compounds have increased significantly, compared to the previous period,especially for those natural compounds that have antioxidant, antimicrobial, and anti-inflammatory properties. Accordingly, organic acids arenoteworthy in this direction since studies have confirmed some organic acids' antioxidant, antimicrobial, and anti-inflammatory effects. It is known thatwine from vine products is one of the rich sources of organic acids. Therefore, the waste products of wine production - including wine lees areinteresting from this point of view. Winemaking is one of the most successful directions of agriculture in Georgia. Many waste products, such as grapepomace, grape seed, and wine lees, accompany wine production. It was the reason to use the waste product - wine lees- to study organic acids.Hence, the research aims to assess the potential of using a currently wasted winery product - Georgian wine lees as a source of biologically activeingredients. The objective of the current study was to identify the biologically active substances (organic acids) in the waste product of winemaking -wine lees obtained from widely distributed grape varieties in Georgia and to determine their quantitative content. By the LC-MS/MS method, weidentified organic acids in 6 samples of wine lees made from different varieties of Georgian grapes (Saperavi, Kisi, Rkatsiteli) and with differenttechnologies (traditional Kakhetian, factory conditions) and determined three main organic acids (tartaric acid, lactic acid, and citric acid) quantitatively.The results of the current research showed that the grape variety and the winemaking technology affect the qualitative and quantitative content oforganic acids in the wine; in particular, three organic acids were found in the Saferavi wine made by the factory method, and 2 organic acids in thewine made by the traditional Kakhetian (Georgia) method. Organic acid's quantitative content is also different. Also, the content of organic acids in thewine obtained from different varieties of grapes is different. The research showed that the quantitative content of organic acids in Kisi wine Lees ishigher than the other studied varieties. However, the content of organic acids in all three types of wine is significant. The study results support thepotential of using a currently wasted product - Georgian Wine Lees - as a source of biologically active ingredients.
{"title":"Qualitative And Quantitative Analysis Of Organic Acids In Georgian Wine Lees By LCMS/ MS Method","authors":"Tamar Kirvalidze, Tamaz Murtazashvili, Lasha Bakuridze, Malkhaz Jokhadze, Koba Sivsivadze","doi":"10.22376/ijlpr.2023.13.5.p191-p198","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.p191-p198","url":null,"abstract":"In the XXI century, the interest and demand for natural compounds have increased significantly, compared to the previous period,especially for those natural compounds that have antioxidant, antimicrobial, and anti-inflammatory properties. Accordingly, organic acids arenoteworthy in this direction since studies have confirmed some organic acids' antioxidant, antimicrobial, and anti-inflammatory effects. It is known thatwine from vine products is one of the rich sources of organic acids. Therefore, the waste products of wine production - including wine lees areinteresting from this point of view. Winemaking is one of the most successful directions of agriculture in Georgia. Many waste products, such as grapepomace, grape seed, and wine lees, accompany wine production. It was the reason to use the waste product - wine lees- to study organic acids.Hence, the research aims to assess the potential of using a currently wasted winery product - Georgian wine lees as a source of biologically activeingredients. The objective of the current study was to identify the biologically active substances (organic acids) in the waste product of winemaking -wine lees obtained from widely distributed grape varieties in Georgia and to determine their quantitative content. By the LC-MS/MS method, weidentified organic acids in 6 samples of wine lees made from different varieties of Georgian grapes (Saperavi, Kisi, Rkatsiteli) and with differenttechnologies (traditional Kakhetian, factory conditions) and determined three main organic acids (tartaric acid, lactic acid, and citric acid) quantitatively.The results of the current research showed that the grape variety and the winemaking technology affect the qualitative and quantitative content oforganic acids in the wine; in particular, three organic acids were found in the Saferavi wine made by the factory method, and 2 organic acids in thewine made by the traditional Kakhetian (Georgia) method. Organic acid's quantitative content is also different. Also, the content of organic acids in thewine obtained from different varieties of grapes is different. The research showed that the quantitative content of organic acids in Kisi wine Lees ishigher than the other studied varieties. However, the content of organic acids in all three types of wine is significant. The study results support thepotential of using a currently wasted product - Georgian Wine Lees - as a source of biologically active ingredients.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136236510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.22376/ijlpr.2023.13.5.p255-p272
Dr Parthiv Shah, Dr Umang R Sachapara, Dr Nitin S. Patil
Osteoarthritis/Osteoarthrosis (OA) defines an idiopathic, slowly progressive disease of the diarthrodial (synovial)joints. Intra-articular - Hyaluronic acid has been proposed to have many therapeutic mechanisms of action in the OA knee,including shock absorption, joint lubrication, anti-inflammatory effects, chondroprotection, proteoglycan synthesis, and cartilagematrix alterations. Thirty-six patients were selected for the proposed study based on eligibility criteria, study period, andfeasibility. Patients with clinical symptoms of osteoarthritis were screened based on inclusion (grades 1 and 2) and exclusioncriteria (previous history of trauma). Patients with grade I or II Osteoarthritis based on Kellegren & Lawrence grading weretaken up for the study. After obtaining informed consent, a structured interview schedule was administered to obtaininformation on their background characteristics and clinical and functional outcome of Osteoarthritis using VAS (Visual AnalogueScale) and WOMAC (The Western Ontario and McMaster Universities Osteoarthritis Index) tools. Following this, theintervention was done. All the patients were given a single injection(6ml) of high molecular weight Hyaluronic acid. This studywas done to verify safety and feasibility. Our findings suggest that intra-articular hyaluronic acid is safe for use with kneeosteoarthritis. While local and minor adverse events related to hyaluronic acid injection occurred, all symptoms disappearedwithin 48 hours.
骨关节炎/骨关节病(OA)是一种特发性、缓慢进展的腹泻(滑膜)关节疾病。关节内透明质酸被认为在OA膝关节中具有多种治疗机制，包括减震、关节润滑、抗炎作用、软骨保护、蛋白多糖合成和软骨基质改变。根据入选标准、研究期限和可行性，选择了36例患者参加拟议的研究。根据纳入(1级和2级)和排除标准(既往创伤史)筛选有骨关节炎临床症状的患者。I级或II级骨关节炎患者(Kellegren &劳伦斯的评分被用于这项研究。在获得知情同意后，使用VAS (Visual AnalogueScale)和WOMAC (The Western Ontario and McMaster university Osteoarthritis Index)工具进行结构化访谈，以获取他们的背景特征以及骨关节炎的临床和功能结果信息。在此之后，进行了干预。所有患者均给予高分子量透明质酸单次注射(6ml)。本研究是为了验证其安全性和可行性。我们的研究结果表明关节内透明质酸对于治疗膝关节炎是安全的。虽然发生了与透明质酸注射有关的局部和轻微不良事件，但所有症状在48小时内消失。
{"title":"Functional Outcome of Intra-Articular Hyaluronic Acid Injection in Osteoarthritis of Knee Joint","authors":"Dr Parthiv Shah, Dr Umang R Sachapara, Dr Nitin S. Patil","doi":"10.22376/ijlpr.2023.13.5.p255-p272","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.p255-p272","url":null,"abstract":"Osteoarthritis/Osteoarthrosis (OA) defines an idiopathic, slowly progressive disease of the diarthrodial (synovial)joints. Intra-articular - Hyaluronic acid has been proposed to have many therapeutic mechanisms of action in the OA knee,including shock absorption, joint lubrication, anti-inflammatory effects, chondroprotection, proteoglycan synthesis, and cartilagematrix alterations. Thirty-six patients were selected for the proposed study based on eligibility criteria, study period, andfeasibility. Patients with clinical symptoms of osteoarthritis were screened based on inclusion (grades 1 and 2) and exclusioncriteria (previous history of trauma). Patients with grade I or II Osteoarthritis based on Kellegren & Lawrence grading weretaken up for the study. After obtaining informed consent, a structured interview schedule was administered to obtaininformation on their background characteristics and clinical and functional outcome of Osteoarthritis using VAS (Visual AnalogueScale) and WOMAC (The Western Ontario and McMaster Universities Osteoarthritis Index) tools. Following this, theintervention was done. All the patients were given a single injection(6ml) of high molecular weight Hyaluronic acid. This studywas done to verify safety and feasibility. Our findings suggest that intra-articular hyaluronic acid is safe for use with kneeosteoarthritis. While local and minor adverse events related to hyaluronic acid injection occurred, all symptoms disappearedwithin 48 hours.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135389417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.22376/ijlpr.2023.13.5.l392-l398
G. Priyanka, M. Kumaresan, Sangeetha Achuthan, Chaturitha. K, Gunapriya Raghunath
Examinations are the greater source of anxiety in medical education, and they can be greatly affected by the residential status of medical students. The study compares the academic performance between the day scholar students and the hostelers pursuing the first year of MBBS. This study was conducted at Saveetha Medical College, Chennai, India. Assessment of the marks obtained by both groups of students was done. Two exams, one theory and one practical exam, including viva voce, were taken for analysis. All 149 students attended both exams. Students in both categories were divided into 4 groups according to the marks obtained. Students who obtained < 50% marks were categorized as Group A, 50 to 69 % as Group B, 70% to 89% as Group C, and> 90% as Group D. In this study, 149 students participated. Among these, 82 students (55.03%) were day scholars, and 67 (44.96%) were hostelers. In the theory exam, 59.8% of day scholars belonged to Group B compared to 55.2% of hostelers. Only 6.09% of day scholar students were in group A as opposed to 19.4% of Hostelers in the same group. In Practical exams, amongst day scholars, 52.4% were in group B compared to 46.2% of hostelers in the same group. Only 4.9% of day scholars were in Group A as opposed to 19.4% of hostelers in the same group. There was a significant difference academically between the two groups of students involved in this study. The day scholars performed better than Hostelers in academics.
{"title":"Comparative Study On the Academic Performance of Day Scholar and Hostel Medical Undergraduate Students","authors":"G. Priyanka, M. Kumaresan, Sangeetha Achuthan, Chaturitha. K, Gunapriya Raghunath","doi":"10.22376/ijlpr.2023.13.5.l392-l398","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l392-l398","url":null,"abstract":"Examinations are the greater source of anxiety in medical education, and they can be greatly affected by the residential status of medical students. The study compares the academic performance between the day scholar students and the hostelers pursuing the first year of MBBS. This study was conducted at Saveetha Medical College, Chennai, India. Assessment of the marks obtained by both groups of students was done. Two exams, one theory and one practical exam, including viva voce, were taken for analysis. All 149 students attended both exams. Students in both categories were divided into 4 groups according to the marks obtained. Students who obtained < 50% marks were categorized as Group A, 50 to 69 % as Group B, 70% to 89% as Group C, and> 90% as Group D. In this study, 149 students participated. Among these, 82 students (55.03%) were day scholars, and 67 (44.96%) were hostelers. In the theory exam, 59.8% of day scholars belonged to Group B compared to 55.2% of hostelers. Only 6.09% of day scholar students were in group A as opposed to 19.4% of Hostelers in the same group. In Practical exams, amongst day scholars, 52.4% were in group B compared to 46.2% of hostelers in the same group. Only 4.9% of day scholars were in Group A as opposed to 19.4% of hostelers in the same group. There was a significant difference academically between the two groups of students involved in this study. The day scholars performed better than Hostelers in academics.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135428264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.22376/ijlpr.2023.13.5.l377-l386
Dr. Parth Shah, Dr. Nareshkumar Dhaniwala, Dr. Poornima Pandey
The standard nailing of both bone forearm fractures of the radius and ulna poses a possible complication of nail migration androtational instability, despite being one of the best reduction techniques. This study has strived to evaluate how effectively screw elasticintramedullary nail is useful in the therapy for mature diaphyseal fractures of both bone forearms. The issues faced with conventional nailingtechniques for managing forearm fractures have also been discussed. A prospective evaluation of twenty-one cases with forearm fractures (radiusand ulna or isolated fracture of the single bone) was done. Out of the twenty-one cases studied, eighteen patients had undergone closedreduction, and three cases required mini-open reduction. The fracture was categorized as claimed by Arbeitsgemeinschaft furOsteosynthesefragen (AO) Foundation/Orthopedic Trauma Association(OTA). The results were evaluated according to Anderson criteria, inwhich 13 cases had excellent results, 4 had good results, 3 had an unsatisfactory result, and 1 was reported as failure. Also, there was 1 case ofsynostosis and 1 case of delayed union in radius. We concluded that the intramedullary screw nail for forearm fractures in adults could be used asa good internal fixation therapy giving excellent functional and radiological results. This technique is easy to learn, and the implant used is alsocost-effective, thus, providing a good fixation of the fracture. The most accepted technique for forearm fracture, as per current recommendationand AO, are open reductions and internal fixation with plating, but our study is exclusive since it helped to overcome the failure of conventionalnailing of both forearm bones with the potential complication of nail migration and rotational instability in spite the best reduction.
{"title":"Management of Radius and / Or Ulna Fracture by Screw Intramedullary Nail in Skeletally Mature Patients","authors":"Dr. Parth Shah, Dr. Nareshkumar Dhaniwala, Dr. Poornima Pandey","doi":"10.22376/ijlpr.2023.13.5.l377-l386","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l377-l386","url":null,"abstract":"The standard nailing of both bone forearm fractures of the radius and ulna poses a possible complication of nail migration androtational instability, despite being one of the best reduction techniques. This study has strived to evaluate how effectively screw elasticintramedullary nail is useful in the therapy for mature diaphyseal fractures of both bone forearms. The issues faced with conventional nailingtechniques for managing forearm fractures have also been discussed. A prospective evaluation of twenty-one cases with forearm fractures (radiusand ulna or isolated fracture of the single bone) was done. Out of the twenty-one cases studied, eighteen patients had undergone closedreduction, and three cases required mini-open reduction. The fracture was categorized as claimed by Arbeitsgemeinschaft furOsteosynthesefragen (AO) Foundation/Orthopedic Trauma Association(OTA). The results were evaluated according to Anderson criteria, inwhich 13 cases had excellent results, 4 had good results, 3 had an unsatisfactory result, and 1 was reported as failure. Also, there was 1 case ofsynostosis and 1 case of delayed union in radius. We concluded that the intramedullary screw nail for forearm fractures in adults could be used asa good internal fixation therapy giving excellent functional and radiological results. This technique is easy to learn, and the implant used is alsocost-effective, thus, providing a good fixation of the fracture. The most accepted technique for forearm fracture, as per current recommendationand AO, are open reductions and internal fixation with plating, but our study is exclusive since it helped to overcome the failure of conventionalnailing of both forearm bones with the potential complication of nail migration and rotational instability in spite the best reduction.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.22376/ijlpr.2023.13.5.l425-l432
Raghad Alharbi, Abdullah Alfozan, Hind Jrais, Raghad Al-Awn, Imtinan Ibrahim, Samah Alotaibi, Laila Aljifry, Maryam Alrawi, Omar Amer
Transplantation is the preferred therapy for terminal organ disease because it improves patients' long-term survival and quality of life. This study aimed to assess knowledge, attitudes, and practices regarding organ donation among medical students and doctors across Saudi Arabia. It is a cross-sectional study using a questionnaire distributed online through social media. The 32-item questionnaire was adapted from a previous study to assess organ donation knowledge, attitudes, and practices among medical students and doctors in Saudi Arabia. Participants demonstrate a moderate level of knowledge, with an average total knowledge score of 6.5 out of 12. Females have higher knowledge scores than males (p=0.037), and married participants score higher than non-married individuals (p=0.031). Interns and doctors score higher than medical students (p<0.001). Most participants support organ donation (85.13%), feel comfortable discussing it (81.28%), and are willing to donate their organs (61.03%). However, concerns about premature treatment termination for registered donors (35.64%) and the belief that your body should be kept intact after death (56.67%) are present. A minority have pledged or signed to donate (33.59%), and even fewer have donated organs (13.59%). Medical professionals in Saudi Arabia have moderate knowledge and good attitudes, but some are concerned about premature treatment termination for donors and fear of disfigurement. The findings highlight the need for educational interventions to improve knowledge and address concerns to bridge the gap between attitudes and actual organ donation practices.
{"title":"Knowledge, Attitude, and Practice of Medical Professionals About Organ Donation and Transplantation in Saudi Arabia: A Cross-Sectional Study","authors":"Raghad Alharbi, Abdullah Alfozan, Hind Jrais, Raghad Al-Awn, Imtinan Ibrahim, Samah Alotaibi, Laila Aljifry, Maryam Alrawi, Omar Amer","doi":"10.22376/ijlpr.2023.13.5.l425-l432","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.l425-l432","url":null,"abstract":"Transplantation is the preferred therapy for terminal organ disease because it improves patients' long-term survival and quality of life. This study aimed to assess knowledge, attitudes, and practices regarding organ donation among medical students and doctors across Saudi Arabia. It is a cross-sectional study using a questionnaire distributed online through social media. The 32-item questionnaire was adapted from a previous study to assess organ donation knowledge, attitudes, and practices among medical students and doctors in Saudi Arabia. Participants demonstrate a moderate level of knowledge, with an average total knowledge score of 6.5 out of 12. Females have higher knowledge scores than males (p=0.037), and married participants score higher than non-married individuals (p=0.031). Interns and doctors score higher than medical students (p<0.001). Most participants support organ donation (85.13%), feel comfortable discussing it (81.28%), and are willing to donate their organs (61.03%). However, concerns about premature treatment termination for registered donors (35.64%) and the belief that your body should be kept intact after death (56.67%) are present. A minority have pledged or signed to donate (33.59%), and even fewer have donated organs (13.59%). Medical professionals in Saudi Arabia have moderate knowledge and good attitudes, but some are concerned about premature treatment termination for donors and fear of disfigurement. The findings highlight the need for educational interventions to improve knowledge and address concerns to bridge the gap between attitudes and actual organ donation practices.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.22376/ijlpr.2023.13.5.p199-p220
Aejaz Ahmed, Manjra Mehfuza U, Lajporiya Mubina, Sayyed Nazifa, Patel Seema, G. J. Khan, Qazi Majaz Ahamad
This study proposes to develop and validate the RP-HPLC method for Bilastine (BIL) and Montelukast (MKT) byQbD to substantiate the RP-HPLC analysis as per ICH validation guidelines. Quality by Design (QbD) allows the accomplishmentof specific unsurprising quality with a predetermined and wanted determination. The simultaneous estimation of BIL and MKTwas performed with C18 (4.6×250 mm, 5-μm particle size) with an LC-10AD pump and PDA detector. The mobile phaseemployed methanol and ammonium acetate buffer pH-3.6 at 85:15 v/v. The flow rate was maintained at 1.0 ml/min, and BIL andMKT were detected at 249nm and 293 nm by UV detector, respectively. The HPLC method provided linear responses found inthe 200–600 μg/ml range. The correlation coefficient was 0.9995 for BIL and 0.9991 for MKT. The LOD and LOQ for BIL andMKT were found to be 0.493, 1.495 μg/ml, and 0.693, 2.100, respectively. The percentage recovery for BIL was 95.33 to 102.06,and for MKT was 96.31 to 104.05, respectively. Calculated information acquired for both the preliminaries roughly coordinateswith the information given by Design expert programming, showing the chromatographic condition's genuineness. Design-Expertversion 10 ("DX10") software has calculated this calculation, setting a composite design of significant parameters. A newselective, rapid, accurate, precise, and sensitive RP-HPLC method was developed and evaluated for the simultaneousdetermination of Bilastine (BIL) and Montelukast sodium (MKT) in a bulk and pharmaceutical dosage form. This method is usefulin the routine quality analysis of combinations of BIL and MKT in bulk and its tablet formulations.
{"title":"Development of RP-HPLC Method for Simultaneous Determination of Bilastine and Montelukast by Qbd Approach and Its Validation","authors":"Aejaz Ahmed, Manjra Mehfuza U, Lajporiya Mubina, Sayyed Nazifa, Patel Seema, G. J. Khan, Qazi Majaz Ahamad","doi":"10.22376/ijlpr.2023.13.5.p199-p220","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.p199-p220","url":null,"abstract":"This study proposes to develop and validate the RP-HPLC method for Bilastine (BIL) and Montelukast (MKT) byQbD to substantiate the RP-HPLC analysis as per ICH validation guidelines. Quality by Design (QbD) allows the accomplishmentof specific unsurprising quality with a predetermined and wanted determination. The simultaneous estimation of BIL and MKTwas performed with C18 (4.6×250 mm, 5-μm particle size) with an LC-10AD pump and PDA detector. The mobile phaseemployed methanol and ammonium acetate buffer pH-3.6 at 85:15 v/v. The flow rate was maintained at 1.0 ml/min, and BIL andMKT were detected at 249nm and 293 nm by UV detector, respectively. The HPLC method provided linear responses found inthe 200–600 μg/ml range. The correlation coefficient was 0.9995 for BIL and 0.9991 for MKT. The LOD and LOQ for BIL andMKT were found to be 0.493, 1.495 μg/ml, and 0.693, 2.100, respectively. The percentage recovery for BIL was 95.33 to 102.06,and for MKT was 96.31 to 104.05, respectively. Calculated information acquired for both the preliminaries roughly coordinateswith the information given by Design expert programming, showing the chromatographic condition's genuineness. Design-Expertversion 10 (\"DX10\") software has calculated this calculation, setting a composite design of significant parameters. A newselective, rapid, accurate, precise, and sensitive RP-HPLC method was developed and evaluated for the simultaneousdetermination of Bilastine (BIL) and Montelukast sodium (MKT) in a bulk and pharmaceutical dosage form. This method is usefulin the routine quality analysis of combinations of BIL and MKT in bulk and its tablet formulations.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43001955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.22376/ijlpr.2023.13.5.p241-p254
Thomas Sudha, Palani Kumar Nallasivan, Munnusamy Vijayakumar Saranya, Arumugam Sarveswaran
This research paper illustrates a latterly developed, optimized and validated gradient RP-HPLC approach for simultaneous analysis ofIndapamide, Perindopril erbumine and Amlodipine besylate in bulk and pharmaceutical formulation with the assistance of quality by design. Qualityis predicated on desired and predetermined specifications. Understanding various factors, dependent variables, and their interconnection effectsby a desired set of experiments on the responses to be analyzed is an important component of QbD. Several operating conditions of variousprocesses optimization, chromatographic separation performance improvement, and high extraction efficiency were attained by using QbD. Thepowerful chromatographic conditions were done using the HypersilC18 column (250mm × 4.6mm, 5μm particle Size). The UV detector wasadjusted to 215nm. Design of experiments (DoE) was applied for multivariate optimization of the experimental conditions of the RP-HPLCmethod. Three independent factors, mobile phase composition, phosphate buffer strength, and flow rate, were used to design mathematicalmodels. Central composite design (CCD) was used to examine the response surface methodology and fully examine the results of theseindependent factors. The desirability function was used to optimize the retention time and resolution of the analytes simultaneously. Theimproved and anticipated data from the contour diagram consisted of methanol and phosphate buffer (pH 2.5, strength 0.05M) in the ratio of65:35, respectively, at a flow rate of 1.1 ml/min. Using these optimum conditions, baseline separation of both drugs with good resolution and runtime of less than 5.0 min was achieved. The novelty of the developed method was time-consuming, cost-effective, and sensitive. The optimizedassay conditions were validated according to ICH guidelines. Under the optimized state, the linearity ranges were found to be 10-40 μg/mL, 32–128 μg/mL, and 40-160 μg/mL for Indapamide, Perindopril erbumine, and amlodipine besylate, respectively, with correlation coefficients (R2) of0.999. The mean accuracy studied ranged from 99.18 to 99.58%. The percentage coefficient variation value for the precision study was lower than1%. The proposed method showed good precision and repeatability. Hence the developed RP-HPLC method using quality by design can be usedas a routine quality control analysis of indapamide, perindopril erbumine, and amlodipine besylate.
{"title":"Development and Validation of Chemometric Assisted RP-HPLC Method for Simultaneous Estimation of Perindopril Erbumine, Indapamide, and Amlodipine Besylate in Bulk and Pharmaceutical Formulation","authors":"Thomas Sudha, Palani Kumar Nallasivan, Munnusamy Vijayakumar Saranya, Arumugam Sarveswaran","doi":"10.22376/ijlpr.2023.13.5.p241-p254","DOIUrl":"https://doi.org/10.22376/ijlpr.2023.13.5.p241-p254","url":null,"abstract":"This research paper illustrates a latterly developed, optimized and validated gradient RP-HPLC approach for simultaneous analysis ofIndapamide, Perindopril erbumine and Amlodipine besylate in bulk and pharmaceutical formulation with the assistance of quality by design. Qualityis predicated on desired and predetermined specifications. Understanding various factors, dependent variables, and their interconnection effectsby a desired set of experiments on the responses to be analyzed is an important component of QbD. Several operating conditions of variousprocesses optimization, chromatographic separation performance improvement, and high extraction efficiency were attained by using QbD. Thepowerful chromatographic conditions were done using the HypersilC18 column (250mm × 4.6mm, 5μm particle Size). The UV detector wasadjusted to 215nm. Design of experiments (DoE) was applied for multivariate optimization of the experimental conditions of the RP-HPLCmethod. Three independent factors, mobile phase composition, phosphate buffer strength, and flow rate, were used to design mathematicalmodels. Central composite design (CCD) was used to examine the response surface methodology and fully examine the results of theseindependent factors. The desirability function was used to optimize the retention time and resolution of the analytes simultaneously. Theimproved and anticipated data from the contour diagram consisted of methanol and phosphate buffer (pH 2.5, strength 0.05M) in the ratio of65:35, respectively, at a flow rate of 1.1 ml/min. Using these optimum conditions, baseline separation of both drugs with good resolution and runtime of less than 5.0 min was achieved. The novelty of the developed method was time-consuming, cost-effective, and sensitive. The optimizedassay conditions were validated according to ICH guidelines. Under the optimized state, the linearity ranges were found to be 10-40 μg/mL, 32–128 μg/mL, and 40-160 μg/mL for Indapamide, Perindopril erbumine, and amlodipine besylate, respectively, with correlation coefficients (R2) of0.999. The mean accuracy studied ranged from 99.18 to 99.58%. The percentage coefficient variation value for the precision study was lower than1%. The proposed method showed good precision and repeatability. Hence the developed RP-HPLC method using quality by design can be usedas a routine quality control analysis of indapamide, perindopril erbumine, and amlodipine besylate.","PeriodicalId":44665,"journal":{"name":"International Journal of Life Science and Pharma Research","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44575151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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