In the framework of comprehensive assessment of explosion risks on board of spacecrafts and on the facilities of launch places, the paper is focused on the detailed analysis of particular scenarios of deflagration-to-detonation transition taking place in smooth tubes filled with acetylene-oxygen mixtures of different compositions. By means of precise numerical simulation it is demonstrated that various scenarios of detonation onset can take place depending on the mixture composition and its initial thermodynamic state. It is demonstrated that independent on the particular scenario always the basic mechanism of detonation onset via the formation of strong enough shock wave takes place. In more reactive mixtures the strong shock originates from the self-sustained process of joint pressure build up and reaction intensification exactly at the flame front. In less reactive mixtures the transient flow behavior leads to the shock waves generation and interaction. As a result, a brand new reaction kernel could arise in the area of shock waves interaction. In number of cases, that leads to the coupling between the shock wave and the newborn reaction front and results in the strong shock formation and further detonation onset.