Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.925_periodico36_pgs_910_919.pdf
Z. M. A. Hamodat
Adropin is a biomarker for cardiac disease and atherosclerosis. Discovered in 2008, this peptide is involved in controlling the metabolism of carbohydrates and fatty acids. Detailed knowledge of these peptides' mechanisms and the factors that affect their release can provide new diagnostic and treatment of metabolic disorders, including cardiac disease and atherosclerosis. This study aimed to estimate the level of adropin for Iraqi patients with cardiac disease and atherosclerosis and the factors affecting its level and its relationship with the studied variables. This study was conducted on 130 adults, including 90 patients suffering from cardiac disease and atherosclerosis, and 40 uninfected adults were considered a control group. Serum levels of adropin and lipid profile (HDL, LDL, and TC) were estimated . The results of the study showed a significant decrease in the level of adropin (p 0.0001) in the following cases: generally in all patients who affected with cardiac disease and atherosclerosis (4.3 ± 1.5 ng ml) compared with healthy subjects (10.2 ± 2.3 ng mL); in obese patients (3.4 ± 0.7 ng mL) compared to non-obese patients (5.2 ± 1.2 ng mL); in patients who also affected with diabetes mellitus type 2 (3.2 ± 0.8 ng mL) and patients who also affected with hypertension (4.1 ± 1.2 ng mL) when compared with patients who do not have other diseases (5.7 ± 1.5 ng mL). A negative significant correlation between serum adropin level and BMI (r=0.493; p=0.0001), LDL (r=-0.628; p=0.0001) level and TC (r=-0.249, p=0.018) level. A positive significant (r=0.395, P=0.0001) appeared correlation of adropin level with HDL level. It was observed that a lower adropin level could play a vital role in cardiac pathophysiology and atherosclerosis. Also, a decrease in the adropin level can be considered a risk factor for these patients. Therefore, measurement and surveillance of changes in serum adropin can consider as a new diagnosis and assessment of disease progression.
{"title":"ESTIMATION THE LEVEL OF ADROPIN FOR IRAQI PATIENTS WITH CARDIAC DISEASE AND ATHEROSCLEROSIS AND THE FACTORS AFFECTING ITS LEVEL","authors":"Z. M. A. Hamodat","doi":"10.52571/ptq.v17.n36.2020.925_periodico36_pgs_910_919.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.925_periodico36_pgs_910_919.pdf","url":null,"abstract":"\u0000Adropin is a biomarker for cardiac disease and atherosclerosis. Discovered in 2008, this peptide is involved in controlling the metabolism of carbohydrates and fatty acids. Detailed knowledge of these peptides' mechanisms and the factors that affect their release can provide new diagnostic and treatment of metabolic disorders, including cardiac disease and atherosclerosis. This study aimed to estimate the level of adropin for Iraqi patients with cardiac disease and atherosclerosis and the factors affecting its level and its relationship with the studied variables. This study was conducted on 130 adults, including 90 patients suffering from cardiac disease and atherosclerosis, and 40 uninfected adults were considered a control group. Serum levels of adropin and lipid profile (HDL, LDL, and TC) were estimated . The results of the study showed a significant decrease in the level of adropin (p 0.0001) in the following cases: generally in all patients who affected with cardiac disease and atherosclerosis (4.3 ± 1.5 ng ml) compared with healthy subjects (10.2 ± 2.3 ng mL); in obese patients (3.4 ± 0.7 ng mL) compared to non-obese patients (5.2 ± 1.2 ng mL); in patients who also affected with diabetes mellitus type 2 (3.2 ± 0.8 ng mL) and patients who also affected with hypertension (4.1 ± 1.2 ng mL) when compared with patients who do not have other diseases (5.7 ± 1.5 ng mL). A negative significant correlation between serum adropin level and BMI (r=0.493; p=0.0001), LDL (r=-0.628; p=0.0001) level and TC (r=-0.249, p=0.018) level. A positive significant (r=0.395, P=0.0001) appeared correlation of adropin level with HDL level. It was observed that a lower adropin level could play a vital role in cardiac pathophysiology and atherosclerosis. Also, a decrease in the adropin level can be considered a risk factor for these patients. Therefore, measurement and surveillance of changes in serum adropin can consider as a new diagnosis and assessment of disease progression.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49234682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.135_periodico36_pgs_119_127.pdf
M. Serikkyzy, A. Avdeenko, Yoro Ella Gouly, I. Tyurin, D. Stepanova
The purpose of the study was to evaluate the efficacy of soybean seed treatment with desiccants and through post-harvest drying. A total of 120 quadruplicate study sites were divided into two groups of 60, one of which was not sprayed with desiccants (control sites), and the other received desiccant treatment (experimental sites). A week after the beginning of the experiment, seeds from experimental sites had 1.5 times less moisture content than seeds from control sites (p ≤ 0.05). The peak lipase activity of seeds was recorded during the first 50 days of storage. The lipoxygenase activity was found to increase between 50 and 100 days of seed storage. The activity of lipase in seeds increased significantly at 60 °C (p ≤ 0.05), but with the subsequent increase in temperature to 80 and 100 °C, a noticeable reduction was recorded (p ≤ 0.01). For lipoxygenase, a similar decrease in activity reaction was noticed at temperatures of drying agents starting from 80 °C. For other factors, no similar results were recorded. This means that the activity of enzymes, in particular, lipase and lipoxygenase, plays a key role in the physiological processes of soybean seeds during storage, but can be inhibited at temperatures starting from 80 °C. Desiccants application accelerates the maturation of the seed to the necessary moisture content for two weeks. After seven days of treatment with Reglon, the yellowing of beans and leaves in the lower part of soybean plants was noted as the moisture content of leaves and beans decreased almost twice to 35%, while on the control site, these values were 48% (p ≤ 0.05).
{"title":"EFFICACY OF SOYBEAN SEEDS SORPTION DRYING AND PREHARVEST TREATMENT WITH DESICCANTS AS A COMPREHENSIVE APPROACH","authors":"M. Serikkyzy, A. Avdeenko, Yoro Ella Gouly, I. Tyurin, D. Stepanova","doi":"10.52571/ptq.v17.n36.2020.135_periodico36_pgs_119_127.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.135_periodico36_pgs_119_127.pdf","url":null,"abstract":"\u0000The purpose of the study was to evaluate the efficacy of soybean seed treatment with desiccants and through post-harvest drying. A total of 120 quadruplicate study sites were divided into two groups of 60, one of which was not sprayed with desiccants (control sites), and the other received desiccant treatment (experimental sites). A week after the beginning of the experiment, seeds from experimental sites had 1.5 times less moisture content than seeds from control sites (p ≤ 0.05). The peak lipase activity of seeds was recorded during the first 50 days of storage. The lipoxygenase activity was found to increase between 50 and 100 days of seed storage. The activity of lipase in seeds increased significantly at 60 °C (p ≤ 0.05), but with the subsequent increase in temperature to 80 and 100 °C, a noticeable reduction was recorded (p ≤ 0.01). For lipoxygenase, a similar decrease in activity reaction was noticed at temperatures of drying agents starting from 80 °C. For other factors, no similar results were recorded. This means that the activity of enzymes, in particular, lipase and lipoxygenase, plays a key role in the physiological processes of soybean seeds during storage, but can be inhibited at temperatures starting from 80 °C. Desiccants application accelerates the maturation of the seed to the necessary moisture content for two weeks. After seven days of treatment with Reglon, the yellowing of beans and leaves in the lower part of soybean plants was noted as the moisture content of leaves and beans decreased almost twice to 35%, while on the control site, these values were 48% (p ≤ 0.05).\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44537715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.661_periodico36_pgs_646_661.pdf
C. Onate, M. Onyeaju, A. Abolarinwa, J. O. Okoro
Schrödinger equation was proposed in theoretical physics to provide information and the behavior of a system of particles. The Schrödinger equation was recently solved for a combination of different potentials using different traditional methodologies. The studies do not consider the effect of a barrier between the potentials. In reality, the barrier between the potentials has an effect on the energy eigenvalues. In the present work, a Kratzer-Mie-type potential, a combination of Kratzer and Mie-type-constant potentials, was proposed as the interacting potential. The solutions of the radial Schrödinger equation was obtained in the presence of the combined potentials by considering a barrier between the potentials. The energy equation and the corresponding wave functions were explicitly calculated. The calculations were performed by using the methodology of supersymmetric quantum mechanics. This method involves the proposition of superpotential function as a solution to its Riccati differential equation. Numerical results were generated for some diatomic molecules using the energy equation and the diatomic model parameters. Some expectation values for the combined potential were calculated using Hellmann Feynman Theorem, and the effect of the barrier on the expectation values were numerically studied. It was observed that when a particle moves from the lower end to a higher end of a barrier, it absorbs energy from the system for some time. This same behavior was also noted when the particle penetrates through a barrier. Thus, its vibration will only depend on the initial energy, which is absorbed. It was equally seen that as the width of the barrier becomes larger than the height, the energy of the system decreases drastically.
{"title":"EFFECT OF A BARRIER ON ENERGY EIGENVALUE OF THE NONRELATIVISTIC (SCHRÖDINGER EQUATION) AND SOME EXPECTATION VALUES OF COMBINED POTENTIALS","authors":"C. Onate, M. Onyeaju, A. Abolarinwa, J. O. Okoro","doi":"10.52571/ptq.v17.n36.2020.661_periodico36_pgs_646_661.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.661_periodico36_pgs_646_661.pdf","url":null,"abstract":"\u0000Schrödinger equation was proposed in theoretical physics to provide information and the behavior of a system of particles. The Schrödinger equation was recently solved for a combination of different potentials using different traditional methodologies. The studies do not consider the effect of a barrier between the potentials. In reality, the barrier between the potentials has an effect on the energy eigenvalues. In the present work, a Kratzer-Mie-type potential, a combination of Kratzer and Mie-type-constant potentials, was proposed as the interacting potential. The solutions of the radial Schrödinger equation was obtained in the presence of the combined potentials by considering a barrier between the potentials. The energy equation and the corresponding wave functions were explicitly calculated. The calculations were performed by using the methodology of supersymmetric quantum mechanics. This method involves the proposition of superpotential function as a solution to its Riccati differential equation. Numerical results were generated for some diatomic molecules using the energy equation and the diatomic model parameters. Some expectation values for the combined potential were calculated using Hellmann Feynman Theorem, and the effect of the barrier on the expectation values were numerically studied. It was observed that when a particle moves from the lower end to a higher end of a barrier, it absorbs energy from the system for some time. This same behavior was also noted when the particle penetrates through a barrier. Thus, its vibration will only depend on the initial energy, which is absorbed. It was equally seen that as the width of the barrier becomes larger than the height, the energy of the system decreases drastically.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43912449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.871_periodico36_pgs_856_870.pdf
R. Orumbayev, A. Kibarin, Balzhan Bakhtiyar, A. S. Kassimov, M. Korobkov
Experience shows that the trend towards using solid fuels in the energy sector of Kazakhstan will be implemented for a rather long time. At the same time, the global trend is currently tightening environmental requirements. They set the task to continue improving coal combustion efficiency and minimize emissions of harmful substances and greenhouse gases into the atmosphere. This article aims to conduct complex thermal engineering tests of the KCVr-0.43 hot water boiler. For this, the following measurement and control tools were used: the standard boiler room secondary devices, an industrial gas analyzer Testo-350, a control (reading) module Testo-454 with temperature probes and a Pitot tube, a soot number meter Testo-308, a temperature meter 2TPM1, a portable liquid flow meter Vzlet-PRC and a stopwatch. All they had valid verification and calibration certificates. An analysis of the gas composition and technical parameters of the KCVr-0.43 hot water boiler in the investigated operation mode with Shubarkul coal during a long-term test showed that it seems possible to operate boilers of this series under low load conditions without boosting air and fuel. They can reduce emissions of toxic NOx and greenhouse gases CO2 into the atmosphere. In this case, burning Shubarkul coal without forcing through the air is characterized by significant carbon monoxide CO emissions. The formed nitrogen oxides NOx decompose in reactions with CO with the formation of molecular nitrogen and oxygen. Burning, coke residue in the layer, coal-burning stages, emissions of harmful substances.
{"title":"RESEARCH OF COMBUSTION MODES DURING LAYER-BURNING OF SHUBARKUL COAL ON THE FIRE GRATE WITH THE HAND FURNACE OF THE KSVR-0.43 HOT WATER BOILER","authors":"R. Orumbayev, A. Kibarin, Balzhan Bakhtiyar, A. S. Kassimov, M. Korobkov","doi":"10.52571/ptq.v17.n36.2020.871_periodico36_pgs_856_870.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.871_periodico36_pgs_856_870.pdf","url":null,"abstract":"\u0000Experience shows that the trend towards using solid fuels in the energy sector of Kazakhstan will be implemented for a rather long time. At the same time, the global trend is currently tightening environmental requirements. They set the task to continue improving coal combustion efficiency and minimize emissions of harmful substances and greenhouse gases into the atmosphere. This article aims to conduct complex thermal engineering tests of the KCVr-0.43 hot water boiler. For this, the following measurement and control tools were used: the standard boiler room secondary devices, an industrial gas analyzer Testo-350, a control (reading) module Testo-454 with temperature probes and a Pitot tube, a soot number meter Testo-308, a temperature meter 2TPM1, a portable liquid flow meter Vzlet-PRC and a stopwatch. All they had valid verification and calibration certificates. An analysis of the gas composition and technical parameters of the KCVr-0.43 hot water boiler in the investigated operation mode with Shubarkul coal during a long-term test showed that it seems possible to operate boilers of this series under low load conditions without boosting air and fuel. They can reduce emissions of toxic NOx and greenhouse gases CO2 into the atmosphere. In this case, burning Shubarkul coal without forcing through the air is characterized by significant carbon monoxide CO emissions. The formed nitrogen oxides NOx decompose in reactions with CO with the formation of molecular nitrogen and oxygen. Burning, coke residue in the layer, coal-burning stages, emissions of harmful substances.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44032686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.455_periodico36_pgs_440_456.pdf
E. Torres, Joan Josep Solaz Portolés, V. S. López
Students’ sensory preferences (SP), that is, the ways or channels they prefer to receive the information, have been proposed as personal factors influencing science learning. Some studies relate improvement in learning to the adequacy of instructional resources to individual SP. A widely used instrument to determine SP is the VARK questionnaire. However, the individual SP has to be reliable to be considered useful to improve instruction. There are not enough studies on the reliability of this questionnaire. This study aimed to assess the reliability (temporal stability) of SP, as measured by the VARK instrument. Also, the reliability of the student’s subjective perception of his/her personal SP was evaluated. A mixed methodology was used, combining techniques for obtaining both quantitative and qualitative information. The sample was made of 582 male and female students, from 7th to 11th grades. The questionnaire was administered twice to a subsample of students, with a few months’ delay. Besides, a small group of students was interviewed. In the analysis of the results, using chi-square tests (X2) and a repeated measure MANCOVA, no massive permanent changes in the group distribution of SP were found along with secondary education. This would be useful for teachers to adapt learning materials to their students’ preferences. The individual SP was stable enough under a permissive criterion, but not when a stricter standard was used. Besides, the reliability of students’ self-perception of SP was low.
{"title":"SECONDARY STUDENTS’ VARK SENSORY PREFERENCES IN SCIENCE LEARNING: ARE THEY RELIABLE?","authors":"E. Torres, Joan Josep Solaz Portolés, V. S. López","doi":"10.52571/ptq.v17.n36.2020.455_periodico36_pgs_440_456.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.455_periodico36_pgs_440_456.pdf","url":null,"abstract":"\u0000Students’ sensory preferences (SP), that is, the ways or channels they prefer to receive the information, have been proposed as personal factors influencing science learning. Some studies relate improvement in learning to the adequacy of instructional resources to individual SP. A widely used instrument to determine SP is the VARK questionnaire. However, the individual SP has to be reliable to be considered useful to improve instruction. There are not enough studies on the reliability of this questionnaire. This study aimed to assess the reliability (temporal stability) of SP, as measured by the VARK instrument. Also, the reliability of the student’s subjective perception of his/her personal SP was evaluated. A mixed methodology was used, combining techniques for obtaining both quantitative and qualitative information. The sample was made of 582 male and female students, from 7th to 11th grades. The questionnaire was administered twice to a subsample of students, with a few months’ delay. Besides, a small group of students was interviewed. In the analysis of the results, using chi-square tests (X2) and a repeated measure MANCOVA, no massive permanent changes in the group distribution of SP were found along with secondary education. This would be useful for teachers to adapt learning materials to their students’ preferences. The individual SP was stable enough under a permissive criterion, but not when a stricter standard was used. Besides, the reliability of students’ self-perception of SP was low.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43182458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.813_periodico36_pgs_798_815.pdf
Sigit Dwi Saputro, A. Tukiran, Z. Supardi, B. Jatmiko
Work and energy are contents traditionally addressed in the study of physics and engineering. This is because this topic is part of people's daily lives; that is, they are critical thinking skills included in 21st century learning achievements that must be mastered by students. This study aimed to make an appropriate assessment formulation to measure students' critical thinking skills in work and energy. The systematic method of review was carried out through three stages. The first step was to search for relevant literature sources through a database and books. The database used included SAGE Journals, Wiley Online Library, Science Direct, and Google Scholar. There were 115 journals or proceedings that have been examined and then selected 50 articles following established criteria. The second stage determined formulating achievement indicators, and the third stage developed conceptual tests of critical thinking skills. Based on this study on the conceptual framework of the study to measure students' critical thinking skills in teaching materials for work and energy, it was concluded that (1) indicators of critical thinking skills on work and energy include interpretation, analysis, evaluation, inference, explanation; (2) the basic principles of making critical thinking test instruments include presenting phenomena, open-ended tests, and testing the rationality of answers; and (3) there were examples of the application of the development of the critical thinking skills test instrument for indicator analysis.
{"title":"CONCEPTUAL FRAMEWORK OF CRITICAL THINKING SKILLS FOR WORK AND ENERGY TESTS APPLIED TO PHYSICS LEARNING","authors":"Sigit Dwi Saputro, A. Tukiran, Z. Supardi, B. Jatmiko","doi":"10.52571/ptq.v17.n36.2020.813_periodico36_pgs_798_815.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.813_periodico36_pgs_798_815.pdf","url":null,"abstract":"\u0000Work and energy are contents traditionally addressed in the study of physics and engineering. This is because this topic is part of people's daily lives; that is, they are critical thinking skills included in 21st century learning achievements that must be mastered by students. This study aimed to make an appropriate assessment formulation to measure students' critical thinking skills in work and energy. The systematic method of review was carried out through three stages. The first step was to search for relevant literature sources through a database and books. The database used included SAGE Journals, Wiley Online Library, Science Direct, and Google Scholar. There were 115 journals or proceedings that have been examined and then selected 50 articles following established criteria. The second stage determined formulating achievement indicators, and the third stage developed conceptual tests of critical thinking skills. Based on this study on the conceptual framework of the study to measure students' critical thinking skills in teaching materials for work and energy, it was concluded that (1) indicators of critical thinking skills on work and energy include interpretation, analysis, evaluation, inference, explanation; (2) the basic principles of making critical thinking test instruments include presenting phenomena, open-ended tests, and testing the rationality of answers; and (3) there were examples of the application of the development of the critical thinking skills test instrument for indicator analysis.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45811491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.1090_periodico36_pgs_1075_1082.pdf
M. Fawzi, A. Taifi, Zahraa K. Lawi
Colorectal cancer (CRC) is one of the most common diagnosis malignancies with different risk factors, including environmental and genetic. Several genes, called tumor suppressor genes, play an essential role in inhibiting these risk factors by preventing tumor development. One of these genes is somatostatin (SST). Somatostatin is an antiproliferative peptide with pro-apoptotic effects that enhance cell death to prevent tumor growth. This study aimed to investigate the association relationship between DNA methylation in SST promotor and colorectal cancer progression. After DNA bisulfite conversion, SST promoter methylation was examined using quantitative methylation‐specific PCR (qMSP) in 71 cases (19 metastasis CRC, 28 early-stage CRC, and 24 healthy controls). Quantitative methylation‐specific PCR (qMSP) is a real-time PCR method used to determine the unmethylated and methylated cytosine residues using a specific set of primers. The percentage of hypermethylation in SST promoter was 17%, 60%, and 79% for healthy controls, early-stage, and metastasis CRC groups. The results showed a significant association between DNA hypermethylation of SST promoter and CRC progression. P-values were 0.0364 for the early-stage group and 0.0138 for the metastasis group. The results also supported that the DNA hypermethylation block the expression of SST, which in turn induce carcinogenesis. The detection of SST promoter hypermethylation at early stage of cancer could be used as a biomarker for screening and prognosis of CRC.
{"title":"SOMATOSTATIN (SST) PROMOTER HYPERMETHYLATION IN ASSOCIATION WITH COLORECTAL CANCER","authors":"M. Fawzi, A. Taifi, Zahraa K. Lawi","doi":"10.52571/ptq.v17.n36.2020.1090_periodico36_pgs_1075_1082.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.1090_periodico36_pgs_1075_1082.pdf","url":null,"abstract":"\u0000Colorectal cancer (CRC) is one of the most common diagnosis malignancies with different risk factors, including environmental and genetic. Several genes, called tumor suppressor genes, play an essential role in inhibiting these risk factors by preventing tumor development. One of these genes is somatostatin (SST). Somatostatin is an antiproliferative peptide with pro-apoptotic effects that enhance cell death to prevent tumor growth. This study aimed to investigate the association relationship between DNA methylation in SST promotor and colorectal cancer progression. After DNA bisulfite conversion, SST promoter methylation was examined using quantitative methylation‐specific PCR (qMSP) in 71 cases (19 metastasis CRC, 28 early-stage CRC, and 24 healthy controls). Quantitative methylation‐specific PCR (qMSP) is a real-time PCR method used to determine the unmethylated and methylated cytosine residues using a specific set of primers. The percentage of hypermethylation in SST promoter was 17%, 60%, and 79% for healthy controls, early-stage, and metastasis CRC groups. The results showed a significant association between DNA hypermethylation of SST promoter and CRC progression. P-values were 0.0364 for the early-stage group and 0.0138 for the metastasis group. The results also supported that the DNA hypermethylation block the expression of SST, which in turn induce carcinogenesis. The detection of SST promoter hypermethylation at early stage of cancer could be used as a biomarker for screening and prognosis of CRC.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45849081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.212_periodico36_pgs_196_212.pdf
N. Suprapto, Azmil Abidah
The term describing the students’ notions of scientific concepts dissimilar from scientifically acceptable by the scientist is still debated. This study explores of how scientific concepts performed by high school students (HSSs), pre-service teachers (PSTs), and in-service teachers (ISTs) simultaneously to make clear between their conception vs. scientists’ conception, especially in the ionization energy concept. Therefore, it is crucial to raise the position of scientific conception and misconception. For diagnosing the misconceptions, some methods can be used: concept maps, interviews, multiple-choice tests (one-tier), multiple-tier tests (two-tier, three-tier, fourtiers), open-ended tests, and others. This study utilized multiple-tier tests with three-tier. Totally, 326 participants from Indonesia, including 118 HSSs, 165 PSTs, and 43 ISTs majoring in chemistry, were invited to complete an online -Ionization Energy Diagnostic-Modification (IEDI*M) test. The test consisted of 12 three-tier diagnostic items. The study indicated four substantial alternative conceptions were acknowledged: conservation of energy, half-filled sub-shells or stable fully-filled, octet rule framework, and relation-based reasoning. ISTs performed better than HSSs and PSTs on the understanding of ionization energy. The study has also specified the distribution of ionization energy conceptions of Group 1 and 2, and Period 2 and 3 on the periodic system. By utilizing the IEDI*M, the percentages of alternative concepts decreased from one-tier to two-tier and from two-tier to three-tier. This study gives some implications for the government, policy-makers, chemistry teachers, preservice teachers, and university faculty members.
{"title":"USING ONLINE THREE-TIER DIAGNOSTIC TEST TO ASSESS CONCEPTIONS OF IONIZATION ENERGY","authors":"N. Suprapto, Azmil Abidah","doi":"10.52571/ptq.v17.n36.2020.212_periodico36_pgs_196_212.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.212_periodico36_pgs_196_212.pdf","url":null,"abstract":"\u0000The term describing the students’ notions of scientific concepts dissimilar from scientifically acceptable by the scientist is still debated. This study explores of how scientific concepts performed by high school students (HSSs), pre-service teachers (PSTs), and in-service teachers (ISTs) simultaneously to make clear between their conception vs. scientists’ conception, especially in the ionization energy concept. Therefore, it is crucial to raise the position of scientific conception and misconception. For diagnosing the misconceptions, some methods can be used: concept maps, interviews, multiple-choice tests (one-tier), multiple-tier tests (two-tier, three-tier, fourtiers), open-ended tests, and others. This study utilized multiple-tier tests with three-tier. Totally, 326 participants from Indonesia, including 118 HSSs, 165 PSTs, and 43 ISTs majoring in chemistry, were invited to complete an online -Ionization Energy Diagnostic-Modification (IEDI*M) test. The test consisted of 12 three-tier diagnostic items. The study indicated four substantial alternative conceptions were acknowledged: conservation of energy, half-filled sub-shells or stable fully-filled, octet rule framework, and relation-based reasoning. ISTs performed better than HSSs and PSTs on the understanding of ionization energy. The study has also specified the distribution of ionization energy conceptions of Group 1 and 2, and Period 2 and 3 on the periodic system. By utilizing the IEDI*M, the percentages of alternative concepts decreased from one-tier to two-tier and from two-tier to three-tier. This study gives some implications for the government, policy-makers, chemistry teachers, preservice teachers, and university faculty members.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46708558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.639_periodico36_pgs_624_633.pdf
H. Budi, W. S. Juliastuti, Winda Ariani
Traditional herbal remedies are naturally occurring, plant-derived substances with limited to no chemical processing and have been used in local or national healing traditions to treat illness. In global health debates, traditional herbal medicines are gaining considerable attention. Many hope new research into herbal medicine will play a vital role in global health. Countries like China, India, Nigeria, USA, and also the World Health Organization (WHO) made large investments in ancient herbal medicines. Currently, the use of the Indonesian plant has dramatically improved the medical and dentistry field. The dental and oral care is often related to wounds, and the Ambonese banana stem has been proven as an effective treatment for these injuries. This study aimed to evaluate the effectiveness and safety of the Ambonese banana stem sap through cytotoxicity tests on the fibroblast cell culture of Baby Hamster Kidney-21 (BHK-21). This study was carried out on three BHK-21 fibroblast cell culture, namely, the media and cell control, and the Ambonese banana stem sap with a concentration of 10%, 20%, 30%, 40%, 50%, 60 %, 70%, 80%, 90%, and 100% incubated for 24 hours at 37ºC and 5% CO2. Then, MTT was evenly dispersed on the media to obtain accurate optical density value. All quantitative data were statistically analyzed using one-way ANOVA and Tukey's HSD Test. The result showed significant differences in optical density values between groups with p = 0.000 (p 0.05). There was no significant difference between the cell control and the Ambonese banana stem sap group with concentrations of 90%, 80%, 70%, 60%, 50%, 30%, 20%, and 10%. It was also observed that the Ambonese banana stem sap is nontoxic to fibroblast cells since its viability value was more than 60%.
{"title":"MTT-BASED CYTOTOXIC EVALUATION OF AMBONESE BANANA STEM SAP (Musa paradisiaca var. sapientum (L.) Kuntze) ON FIBROBLAST CELLS","authors":"H. Budi, W. S. Juliastuti, Winda Ariani","doi":"10.52571/ptq.v17.n36.2020.639_periodico36_pgs_624_633.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.639_periodico36_pgs_624_633.pdf","url":null,"abstract":"\u0000Traditional herbal remedies are naturally occurring, plant-derived substances with limited to no chemical processing and have been used in local or national healing traditions to treat illness. In global health debates, traditional herbal medicines are gaining considerable attention. Many hope new research into herbal medicine will play a vital role in global health. Countries like China, India, Nigeria, USA, and also the World Health Organization (WHO) made large investments in ancient herbal medicines. Currently, the use of the Indonesian plant has dramatically improved the medical and dentistry field. The dental and oral care is often related to wounds, and the Ambonese banana stem has been proven as an effective treatment for these injuries. This study aimed to evaluate the effectiveness and safety of the Ambonese banana stem sap through cytotoxicity tests on the fibroblast cell culture of Baby Hamster Kidney-21 (BHK-21). This study was carried out on three BHK-21 fibroblast cell culture, namely, the media and cell control, and the Ambonese banana stem sap with a concentration of 10%, 20%, 30%, 40%, 50%, 60 %, 70%, 80%, 90%, and 100% incubated for 24 hours at 37ºC and 5% CO2. Then, MTT was evenly dispersed on the media to obtain accurate optical density value. All quantitative data were statistically analyzed using one-way ANOVA and Tukey's HSD Test. The result showed significant differences in optical density values between groups with p = 0.000 (p 0.05). There was no significant difference between the cell control and the Ambonese banana stem sap group with concentrations of 90%, 80%, 70%, 60%, 50%, 30%, 20%, and 10%. It was also observed that the Ambonese banana stem sap is nontoxic to fibroblast cells since its viability value was more than 60%.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46486568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-20DOI: 10.52571/ptq.v17.n36.2020.799_periodico36_pgs_784_797.pdf
Noor K. Saad AL-MAJIDII, H. A. M. Alsaady
Trichomonas vaginalis is an extracellular flagellated parasitic protozoan. It adapts to live in anaerobic conditions of the women's vagina and causes Trichomoniasis, a non-viral, sexually transmitted disease (STD). This parasite spreads in all regions of the world, and the global prevalence rate of vaginal Trichomoniasis in women is higher than in men. It is considered a neglected disease in Iraq, as there are few studies about this parasite, especially in Maysan province, where researches are near absent. In this study, two hundred and twentysix vaginal swabs were collected from women who visited hospitals, health centers, and medical clinics in some areas of Maysan province (Amara district, Al-Kahla district, Al-Maymouna district, Al-Majar Al-Kabir district) during the period from November 10, 2019 to February 10, 2020. The microscopic examination of vaginal smears showed that the overall infection rate was 75.22% (170/226). AL-Kahla district had the highest rate of infection (96.15%), while the lowest was in the Maimouna district (60.00%). The age group 34-40 years had the highest infection rate (86.95%), while the age group 15 years had the lowest infection rate (37.50%). Married women had a higher infection (80.92%) than unmarried women (40.62%). The infection rate among nonpregnant women was high (81.11%) than with pregnant women (78.57%). This study showed that vaginal pH has a significant role in protecting the women vagina from Trichomoniasis, once the highest rate of infection (96.63%) was recorded in the vagina with a pH 6, while no infection was recorded at pH 4. It can be concluded that Trichomoniasis is widely spread among women of the Maysan communities, and the condition was affected significantly by some demographic factors such as age, occupation, marital status, husband polygamous, vaginal secretions, and itching and pH of the vagina.
{"title":"THE PREVALENCE OF TRICHOMONAS VAGINALIS PARASITE AMONG WOMEN IN SOME REGIONS OF MAYSAN PROVINCE","authors":"Noor K. Saad AL-MAJIDII, H. A. M. Alsaady","doi":"10.52571/ptq.v17.n36.2020.799_periodico36_pgs_784_797.pdf","DOIUrl":"https://doi.org/10.52571/ptq.v17.n36.2020.799_periodico36_pgs_784_797.pdf","url":null,"abstract":"\u0000Trichomonas vaginalis is an extracellular flagellated parasitic protozoan. It adapts to live in anaerobic conditions of the women's vagina and causes Trichomoniasis, a non-viral, sexually transmitted disease (STD). This parasite spreads in all regions of the world, and the global prevalence rate of vaginal Trichomoniasis in women is higher than in men. It is considered a neglected disease in Iraq, as there are few studies about this parasite, especially in Maysan province, where researches are near absent. In this study, two hundred and twentysix vaginal swabs were collected from women who visited hospitals, health centers, and medical clinics in some areas of Maysan province (Amara district, Al-Kahla district, Al-Maymouna district, Al-Majar Al-Kabir district) during the period from November 10, 2019 to February 10, 2020. The microscopic examination of vaginal smears showed that the overall infection rate was 75.22% (170/226). AL-Kahla district had the highest rate of infection (96.15%), while the lowest was in the Maimouna district (60.00%). The age group 34-40 years had the highest infection rate (86.95%), while the age group 15 years had the lowest infection rate (37.50%). Married women had a higher infection (80.92%) than unmarried women (40.62%). The infection rate among nonpregnant women was high (81.11%) than with pregnant women (78.57%). This study showed that vaginal pH has a significant role in protecting the women vagina from Trichomoniasis, once the highest rate of infection (96.63%) was recorded in the vagina with a pH 6, while no infection was recorded at pH 4. It can be concluded that Trichomoniasis is widely spread among women of the Maysan communities, and the condition was affected significantly by some demographic factors such as age, occupation, marital status, husband polygamous, vaginal secretions, and itching and pH of the vagina.\u0000","PeriodicalId":45103,"journal":{"name":"Periodico Tche Quimica","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2020-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47575526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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