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Effect of a system-oriented intervention on compliance problems in schizophrenia: a pragmatic controlled trial. 系统导向干预对精神分裂症患者依从性问题的影响:一项实用对照试验。
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-06-02 DOI: 10.1155/2014/789403
Hanne Skarsholm, Henrik Stoevring, Bent Nielsen

Background. Numerous studies have been conducted with a view to developing strategies for improvement of medical compliance in patients with schizophrenia. All of the studies conducted so far have had an individual approach to compliance based on the assumption that noncompliance is determined individually due to inappropriate behavior in the patient. We conducted a pragmatic controlled trial with a system-oriented approach, to provide a new perspective on compliance and test the efficacy of a multifactorial intervention at the system level in a routine clinical setting, an approach that has not previously been used for the improvement of compliance. Methods. 30 patients were allocated to the system-oriented therapy and 40 patients were allocated to the reference intervention, which consisted of individually based compliance therapy. The follow-up period was six months. Primary endpoint was improvement in compliance, measured by improvement in a compliance scale specifically developed for the project. Results. When accounting for missing values with a multiple imputation approach, we found a tendency toward a difference in both the compliance scale and PANSS favoring the system-oriented therapy, although it did not reach statistical significance. A significant difference in incidence of adverse events and time to first readmission was found. Attrition rates were significantly higher in the reference group and nonsignificant among individuals with lower compliance, which may have diluted effect estimates. This was reflected by significant differences found in an analysis based on a last observation carried forward approach. Conclusion. This study suggests that compliance problems are better solved by a multifactorial intervention at the system level than at the individual level.

背景。为了制定改善精神分裂症患者医疗依从性的战略,进行了许多研究。到目前为止进行的所有研究都采用了一种个体方法来确定依从性,这种方法基于这样的假设:不依从性是由于患者的不当行为而单独确定的。我们采用系统导向的方法进行了一项实用的对照试验,以提供对依从性的新视角,并在常规临床环境中测试系统层面多因素干预的有效性,这是一种以前未用于改善依从性的方法。方法:30例患者被分配到系统导向治疗组,40例患者被分配到参考干预组,参考干预组由基于个体的依从性治疗组成。随访期为6个月。主要终点是依从性的改善,通过专门为项目开发的依从性量表的改善来衡量。结果。当用多重归算方法考虑缺失值时,我们发现依从性量表和PANSS的差异倾向于支持系统导向的治疗,尽管没有达到统计学意义。不良事件的发生率和第一次再入院的时间有显著差异。参考组的损耗率显著较高,而依从性较低的个体的损耗率不显著,这可能稀释了效应估计。在基于最后观察结转方法的分析中发现的显著差异反映了这一点。结论。本研究认为,系统层面的多因素干预比个人层面的多因素干预更能解决依从性问题。
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引用次数: 4
Prolactin and psychopathology in schizophrenia: a literature review and reappraisal. 催乳素与精神分裂症的精神病理:文献回顾与再评价。
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-03-27 DOI: 10.1155/2014/175360
Ravi Philip Rajkumar

Secretion of the anterior pituitary hormone prolactin can be significantly increased by antipsychotic drugs, leading to a range of adverse effects in patients with schizophrenia. However, there is evidence from a variety of studies that prolactin may also be related to symptom profile and treatment response in these patients, and recent work has identified variations in prolactin secretion even in drug-free patients. In this paper, a selective review of all relevant studies pertaining to prolactin and schizophrenia, including challenge and provocation studies, is presented. The implications of this work are discussed critically. A tentative model, which synthesizes these findings and argues for a significant role for prolactin in the development of schizophrenia, is outlined.

抗精神病药物可显著增加垂体前叶激素催乳素的分泌,导致精神分裂症患者出现一系列不良反应。然而,各种研究表明,催乳素也可能与这些患者的症状特征和治疗反应有关,最近的研究发现,即使在无药患者中,催乳素分泌也会发生变化。在本文中,选择性回顾所有有关催乳素和精神分裂症的相关研究,包括挑战和挑衅的研究,是提出。对这项工作的意义进行了批判性的讨论。一个试探性的模型,它综合了这些发现,并认为催乳素在精神分裂症的发展中的重要作用,概述。
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引用次数: 36
Eating disorders in schizophrenia: implications for research and management. 精神分裂症的饮食失调:对研究和管理的启示。
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-11-18 DOI: 10.1155/2014/791573
Youssef Kouidrat, Ali Amad, Jean-Daniel Lalau, Gwenole Loas

Objective. Despite evidence from case series, the comorbidity of eating disorders (EDs) with schizophrenia is poorly understood. This review aimed to assess the epidemiological and clinical characteristics of EDs in schizophrenia patients and to examine whether the management of EDs can be improved. Methods. A qualitative review of the published literature was performed using the following terms: "schizophrenia" in association with "eating disorders," "anorexia nervosa," "bulimia nervosa," "binge eating disorder," or "night eating syndrome." Results. According to our literature review, there is a high prevalence of comorbidity between schizophrenia and EDs. EDs may occur together with or independent of psychotic symptoms in these patients. Binge eating disorders and night eating syndromes are frequently found in patients with schizophrenia, with a prevalence of approximately 10%. Anorexia nervosa seems to affect between 1 and 4% of schizophrenia patients. Psychopathological and neurobiological mechanisms, including effects of antipsychotic drugs, should be more extensively explored. Conclusions. The comorbidity of EDs in schizophrenia remains relatively unexplored. The clearest message of this review is the importance of screening for and assessment of comorbid EDs in schizophrenia patients. The management of EDs in schizophrenia requires a multidisciplinary approach to attain maximized health outcomes. For clinical practice, we propose some recommendations regarding patient-centered care.

目标。尽管有来自病例系列的证据,但人们对饮食失调(EDs)与精神分裂症的合并症知之甚少。本文旨在评估精神分裂症患者ed的流行病学和临床特征,并探讨是否可以改善ed的管理。方法。对已发表的文献进行定性回顾,使用以下术语:“精神分裂症”与“饮食失调”、“神经性厌食症”、“神经性贪食症”、“暴食症”或“夜食综合征”相关。结果。根据我们的文献综述,精神分裂症和急症之间的共病发生率很高。在这些患者中,ed可能与精神病症状一起或独立发生。暴食症和夜食综合征常见于精神分裂症患者,患病率约为10%。神经性厌食症似乎影响了1%到4%的精神分裂症患者。精神病理和神经生物学机制,包括抗精神病药物的作用,应该更广泛地探索。结论。精神分裂症中ed的合并症仍然相对未被研究。这篇综述最明确的信息是筛查和评估精神分裂症患者合并症ed的重要性。精神分裂症患者ed的管理需要多学科的方法来获得最大的健康结果。在临床实践中,我们提出了一些以患者为中心的护理建议。
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引用次数: 60
Investigation of anti-Toxocara and anti-toxoplasma antibodies in patients with schizophrenia disorder. 精神分裂症患者抗弓形虫和抗弓形虫抗体的研究。
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-04-16 DOI: 10.1155/2014/230349
Shahram Khademvatan, Niloufar Khajeddin, Sakineh Izadi, Elham Yousefi

Objective. The aim of the present study was to examine the relationship between Toxoplasma gondii and Toxocara spp. infections in patients with schizophrenia disorder. Method. A total of 100 patients with schizophrenia disorder and 95 healthy individuals participated in the study. Participants were tested for the presence of anti-T. gondii and anti-Toxocara spp. antibodies by ELISA and Western blotting. Data were analyzed using Chi-square test and Fisher 9 s exact test. Results. There were no differences in T. gondii IgG seroprevalence between patients with schizophrenia and healthy individuals (P = 0.1), but there were differences in seroprevalence between males and females with schizophrenia (P = 0.009). In contrast, Toxocara spp. IgG seroprevalence was greater in patients with schizophrenia disorder than in healthy individuals (P = 0.02), but there were no differences in seroprevalence between men and women with schizophrenia (P = 0.5). Finally, there were no differences in seroprevalence of T. gondii or Toxocara spp. IgG among different subtypes of schizophrenia, various age groups, residential area, or clinical course of treatment (P > 0.05). Conclusion. The present study suggests that patients with schizophrenia disorder are at elevated risk of Toxocara spp. infection. Moreover, contamination with T. gondii is a risk factor for schizophrenia in women.

目标。本研究旨在探讨精神分裂症患者刚地弓形虫和弓形虫感染之间的关系。方法。共有100名精神分裂症患者和95名健康人参加了这项研究。参与者被检测是否存在抗t病毒。ELISA和Western blotting检测弓形虫和抗弓形虫抗体。数据分析采用卡方检验和Fisher 9s精确检验。结果。精神分裂症患者与健康人群弓形虫IgG血清阳性率差异无统计学意义(P = 0.1),而精神分裂症男性与女性患者弓形虫IgG血清阳性率差异有统计学意义(P = 0.009)。精神分裂症患者弓形虫IgG血清阳性率高于健康人群(P = 0.02),而精神分裂症患者男女弓形虫IgG血清阳性率无差异(P = 0.5)。弓形虫和弓形虫IgG的血清阳性率在精神分裂症不同亚型、不同年龄、不同居住地区、不同病程间差异无统计学意义(P > 0.05)。结论。目前的研究表明,精神分裂症患者感染弓形虫的风险较高。此外,弓形虫污染是女性患精神分裂症的一个危险因素。
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引用次数: 42
Long-term risperidone treatment induces visceral adiposity associated with hepatic steatosis in mice: a magnetic resonance approach. 长期利培酮治疗诱导小鼠肝脂肪变性相关内脏脂肪:磁共振方法。
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-04-27 DOI: 10.1155/2014/429291
Florent Auger, Patrick Duriez, Françoise Martin-Nizard, Nicolas Durieux, Régis Bordet, Olivier Pétrault

Although atypical antipsychotic drugs (APDs) have led to significant advances in the treatment of psychotic disorders, they still induce metabolic disturbances. We aimed at characterizing the metabolic consequences of a risperidone treatment and at establishing a link with noninvasive MR markers, in order to develop a tool for predicting symptoms of the metabolic syndrome. Fat deposition and liver morphometry were assessed by T1-weighted imaging. Fatty acid composition and fat accumulations in tissues were determined using MR spectroscopy with and without water suppression, respectively. Risperidone treatment induced a weight gain accompanied with metabolic disturbances such as hyperglycemic status, an increase in visceral adipose tissue (VAT), and liver fat depositions. Correlations using Methylene-Water Ratio (MWR) and Polyunsaturated Index (PUI) demonstrated a concomitant increase in the weight gain, VAT and liver fat depositions, and a decrease in the quantity of polyunsaturated fatty acids. These results were consistent with a hepatic steatosis state. We evaluated the ability of MR techniques to detect subtle metabolic disorders induced by APDs. Thus, our model and methodology offer the possibility to investigate APDs side effects in order to improve the health conditions of schizophrenic patients.

尽管非典型抗精神病药物(apd)在治疗精神障碍方面取得了重大进展,但它们仍然会引起代谢紊乱。我们的目的是表征利培酮治疗的代谢后果,并建立与无创磁共振标记物的联系,以便开发一种预测代谢综合征症状的工具。通过t1加权成像评估脂肪沉积和肝脏形态。分别采用有水抑制和无水抑制的磁共振光谱法测定脂肪酸组成和脂肪在组织中的积累。利培酮治疗导致体重增加,并伴有代谢紊乱,如高血糖状态、内脏脂肪组织(VAT)增加和肝脏脂肪沉积。利用亚甲基水比(MWR)和多不饱和指数(PUI)的相关性表明,体重增加、VAT和肝脏脂肪沉积同时增加,而多不饱和脂肪酸的数量减少。这些结果与肝脂肪变性状态一致。我们评估了MR技术检测apd引起的细微代谢紊乱的能力。因此,我们的模型和方法为研究apd的副作用提供了可能性,以改善精神分裂症患者的健康状况。
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引用次数: 12
Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone. 黑桫椤果实多酚可降低齐拉西酮诱导的血浆脂质过氧化。
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-06-25 DOI: 10.1155/2014/602390
Anna Dietrich-Muszalska, Justyna Kopka, Bogdan Kontek

Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries of Aronia melanocarpa (Aronox) on the plasma lipid peroxidation induced by ziprasidone in vitro. Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml). Results. We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation: P = 7.0 × 10(-4), P = 1.6 × 10(-3), and P = 2.7 × 10(-3), resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased: P = 6.5 × 10(-8), P = 7.0 × 10(-6), and P = 3.0 × 10(-5), respectively. Conclusion. Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone.

背景。精神分裂症患者的氧化应激可能部分由抗精神病药物治疗引起。本研究旨在探讨黑果野莓(Aronox)多酚类化合物对齐拉西酮诱导的血浆脂质过氧化的影响。方法。脂质过氧化通过硫代巴比妥酸活性物质(TBARS)水平测定。健康人血浆样品用齐拉西酮(40 ng/ml;139 ng / ml;和250 ng/ml)单独和与Aronox (5 ug/ml;50微克/毫升)。结果。我们观察到齐拉西酮(40 ng/ml;139 ng / ml;和250 ng/ml)(孵育24 h后分别P = 7.0 × 10(-4)、P = 1.6 × 10(-3)和P = 2.7 × 10(-3)),齐拉西酮引起的Aronox脂质过氧化显著降低。齐拉西酮(40 ng/ml)血浆孵育24小时后;139 ng / ml;50 ug/ml Aronox存在时,TBARS水平显著降低:P = 6.5 × 10(-8), P = 7.0 × 10(-6), P = 3.0 × 10(-5)。结论。阿罗诺克斯引起由齐拉西酮引起的脂质过氧化明显减少。
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引用次数: 10
Gender identity disorder and schizophrenia: neurodevelopmental disorders with common causal mechanisms? 性别认同障碍与精神分裂症:具有共同因果机制的神经发育障碍?
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-12-04 DOI: 10.1155/2014/463757
Ravi Philip Rajkumar

Gender identity disorder (GID), recently renamed gender dysphoria (GD), is a rare condition characterized by an incongruity between gender identity and biological sex. Clinical evidence suggests that schizophrenia occurs in patients with GID at rates higher than in the general population and that patients with GID may have schizophrenia-like personality traits. Conversely, patients with schizophrenia may experience alterations in gender identity and gender role perception. Neurobiological research, including brain imaging and studies of finger length ratio and handedness, suggests that both these disorders are associated with altered cerebral sexual dimorphism and changes in cerebral lateralization. Various mechanisms, such as Toxoplasma infection, reduced levels of brain-derived neurotrophic factor (BDNF), early childhood adversity, and links with autism spectrum disorders, may account for some of this overlap. The implications of this association for further research are discussed.

性别认同障碍(GID),最近更名为性别焦虑症(GD),是一种罕见的疾病,其特征是性别认同与生理性别之间的不一致。临床证据表明,GID患者发生精神分裂症的比率高于一般人群,并且GID患者可能具有类似精神分裂症的人格特征。相反,精神分裂症患者可能会经历性别认同和性别角色感知的改变。神经生物学研究,包括脑成像和手指长度比和利手性的研究,表明这两种疾病都与大脑性别二态性的改变和大脑侧化的改变有关。各种机制,如弓形虫感染、脑源性神经营养因子(BDNF)水平降低、儿童早期逆境以及与自闭症谱系障碍的联系,可能在一定程度上解释这种重叠。讨论了这一关联对进一步研究的意义。
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引用次数: 42
Not all distraction is bad: working memory vulnerability to implicit socioemotional distraction correlates with negative symptoms and functional impairment in psychosis. 并非所有的分心都是不好的:工作记忆容易受到内隐社会情绪分心的影响,与精神病的负面症状和功能损害有关。
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-02-27 DOI: 10.1155/2014/320948
Quintino R Mano, Gregory G Brown, Heline Mirzakhanian, Khalima Bolden, Kristen S Cadenhead, Gregory A Light

This study investigated implicit socioemotional modulation of working memory (WM) in the context of symptom severity and functional status in individuals with psychosis (N = 21). A delayed match-to-sample task was modified wherein task-irrelevant facial distracters were presented early and briefly during the rehearsal of pseudoword memoranda that varied incrementally in load size (1, 2, or 3 syllables). Facial distracters displayed happy, sad, or emotionally neutral expressions. Implicit socioemotional modulation of WM was indexed by subtracting task accuracy on nonfacial geometrical distraction trials from facial distraction trials. Results indicated that the amount of implicit socioemotional modulation of high WM load accuracy was significantly associated with negative symptoms (r = 0.63, P < 0.01), role functioning (r = -0.50, P < 0.05), social functioning (r = -0.55, P < 0.01), and global assessment of functioning (r = -0.53, P < 0.05). Specifically, greater attentional distraction of high WM load was associated with less severe symptoms and functional impairment. This study demonstrates the importance of the WM-socioemotional interface in influencing clinical and psychosocial functional status in psychosis.

本研究探讨了内隐社会情绪在精神病患者症状严重程度和功能状态下对工作记忆(WM)的调节作用。对延迟匹配样本任务进行了改进,其中任务无关的面部干扰物在假单词记忆的排练中被提前和短暂地呈现,这些假单词记忆的负载大小逐渐变化(1、2或3个音节)。面部干扰显示出快乐、悲伤或情绪中性的表情。内隐社会情绪调节是通过从面部分心试验中减去非面部几何分心试验的任务准确性来索引的。结果显示,高WM负荷准确性的内隐社会情绪调节量与负面症状(r = 0.63, P < 0.01)、角色功能(r = -0.50, P < 0.05)、社会功能(r = -0.55, P < 0.01)和整体功能评估(r = -0.53, P < 0.05)显著相关。具体而言,高WM负荷的注意力分散程度越大,症状和功能损害程度越轻。本研究证明了精神障碍与社会情绪界面在影响精神病患者临床和社会心理功能状态方面的重要性。
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引用次数: 1
Explaining attitudes and adherence to antipsychotic medication: the development of a process model. 解释对抗精神病药物的态度和依从性:过程模型的发展。
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-02-19 DOI: 10.1155/2014/341545
Martin Wiesjahn, Esther Jung, Fabian Lamster, Winfried Rief, Tania M Lincoln

Although nonadherence to antipsychotic medication poses a threat to outcome of medical treatment, the processes preceding the intake behavior have not been investigated sufficiently. This study tests a process model of medication adherence derived from the Health Belief Model which is based on cost-benefit considerations. The model includes an extensive set of potential predictors for medication attitudes and uses these attitudes as a predictor for medication adherence. We conducted an online study of 84 participants with a self-reported psychotic disorder and performed a path analysis. More insight into the need for treatment, a higher attribution of the symptoms to a mental disorder, experience of less negative side effects, presence of biological causal beliefs, and less endorsement of psychological causal beliefs were significant predictors of more positive attitudes towards medication. The results largely supported the postulated process model. Mental health professionals should consider attitudes towards medication and the identified predictors when they address adherence problems with the patient in a shared and informed decision process.

虽然抗精神病药物的不依从性对药物治疗的结果构成威胁,但摄入行为之前的过程尚未得到充分的调查。本研究检验了基于成本效益考量的健康信念模型衍生出的药物依从性过程模型。该模型包括一套广泛的药物态度的潜在预测因素,并使用这些态度作为药物依从性的预测因素。我们对84名自我报告患有精神障碍的参与者进行了一项在线研究,并进行了通径分析。更深入地了解治疗的需要,更容易将症状归因于精神障碍,经历更少的负面副作用,存在生物因果信念,更少支持心理因果信念,这些都是对药物治疗持更积极态度的重要预测因素。结果在很大程度上支持了假设的过程模型。精神卫生专业人员应考虑对药物的态度和确定的预测因素,当他们在一个共享和知情的决策过程中与患者解决依从性问题。
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引用次数: 22
Pomaglumetad Methionil (LY2140023 Monohydrate) and Aripiprazole in Patients with Schizophrenia: A Phase 3, Multicenter, Double-Blind Comparison. Pomaglumetad Methionil (LY2140023 Monohydrate)和阿立哌唑在精神分裂症患者中的作用:3期、多中心、双盲比较
IF 2.4 Q3 Medicine Pub Date : 2014-01-01 Epub Date: 2014-03-19 DOI: 10.1155/2014/758212
David H Adams, Lu Zhang, Brian A Millen, Bruce J Kinon, Juan-Carlos Gomez

We tested the hypothesis that long-term treatment with pomaglumetad methionil would demonstrate significantly less weight gain than aripiprazole in patients with schizophrenia. In this 24-week, multicenter, randomized, double-blind, Phase 3 study, 678 schizophrenia patients were randomized to either pomaglumetad methionil (n = 516) or aripiprazole (n = 162). Treatment groups were also compared on efficacy and various safety measures, including serious adverse events (SAEs), discontinuation due to adverse events (AEs), treatment-emergent adverse events (TEAEs), extrapyramidal symptoms (EPS), and suicide-related thoughts and behaviors. The pomaglumetad methionil group showed significantly greater weight loss at Week 24 (Visit 12) compared with the aripiprazole group (-2.8 ± 0.4 versus 0.4 ± 0.6; P < 0.001). However, change in Positive and Negative Syndrome Scale (PANSS) total scores for aripiprazole was significantly greater than for pomaglumetad methionil (-15.58 ± 1.58 versus -12.03 ± 0.99; P = 0.045). The incidences of SAEs (8.2% versus 3.1%; P = 0.032) and discontinuation due to AEs (16.2% versus 8.7%; P = 0.020) were significantly higher for pomaglumetad methionil compared with aripiprazole. No statistically significant differences in the incidence of TEAEs, EPS, or suicidal ideation or behavior were noted between treatment groups. In conclusion, long-term treatment with pomaglumetad methionil resulted in significantly less weight gain than aripiprazole. This trial is registered with ClinicalTrials.gov NCT01328093.

我们检验了一种假设,即长期使用pomaglumetad methionil治疗精神分裂症患者的体重增加明显少于阿立哌唑。在这项为期24周的多中心、随机、双盲、3期研究中,678名精神分裂症患者被随机分配到pomaglumetad methionil (n = 516)或阿立哌唑(n = 162)组。还比较了治疗组的疗效和各种安全措施,包括严重不良事件(sae)、因不良事件停药(ae)、治疗后出现的不良事件(teae)、锥体外系症状(EPS)和自杀相关的想法和行为。与阿立哌唑组相比,pomaglumetad methionil组在第24周(第12次访问)的体重减轻明显更大(-2.8±0.4 vs 0.4±0.6;P < 0.001)。然而,阿立哌唑组阳性和阴性综合征量表(PANSS)总分的变化显著大于pomaglumetad methionil组(-15.58±1.58 vs -12.03±0.99;P = 0.045)。急性呼吸道感染的发生率(8.2% vs 3.1%;P = 0.032)和因ae而停药(16.2% vs 8.7%;P = 0.020),与阿立哌唑相比,pomaglumetad methionil显著升高。治疗组之间teae、EPS、自杀意念或行为的发生率无统计学差异。总之,与阿立哌唑相比,长期使用pomaglumetad methionil治疗导致的体重增加明显更少。该试验已在ClinicalTrials.gov注册NCT01328093。
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引用次数: 54
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Schizophrenia Research and Treatment
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