Clinical Epidemiology and Global Health最新文献_第5页

Anxiety and depression among nursing students affected by the 2023 Alhaouz earthquake in Morocco: A comprehensive evaluation 受 2023 年摩洛哥 Alhaouz 地震影响的护理专业学生的焦虑和抑郁情况：综合评估

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-09 DOI: 10.1016/j.cegh.2024.101818

Abderrahmane Achbani , Jamila Rida , Ahmed Kharbach , Youssef Bouchriti , Mohamed Boukrim , Hasnaa Sine

Background/objectives

This groundbreaking study marks the initial exploration into the psychological aftermath following the 2023 Alhaouz earthquake. The objective is to scrutinize anxiety and depression among nursing and health technology students in the wake of this seismic event.

Methods

To achieve this, demographic data and anxiety/depression scale measures were systematically gathered through a standardized questionnaire.

Results

revealed that 29.73 % of students directly felt the impact of the earthquake. Depression was reported by 42.01 % of students, with 84.80 % being female, 59.65 % under 20 years old, and 88.89 % pursuing undergraduate studies. It's worth noting that Mental Health Nurse (MHN) students emerged as the least affected group (RR = 0.3455, p < 0.05). Depression was significantly more prevalent among students with a history of depression (RR = 1.5227, p < 0.05). Within the student population, the earthquake's impact was most pronounced among those who evacuated due to uninhabitable or potentially unsafe homes (63.14 %), experienced property loss (27.17 %), and faced the loss of family members (9.58 %). Anxiety affected 37.59 % of students. Notably, anxiety was statistically associated with students directly affected by the disaster (RR = 1.4836, p = 0.0036), as well as those forcibly evacuated from their homes (RR = 1.7663, p = 0.0001). Furthermore, 39.42 % of individuals expressed a sense of impending fear, while 30.3 % exhibited worry, often accompanied by quiet and inactive behavior (57.8 %), feelings of fear, and a tense stomach (21.7 %).

Conclusion

this research underscores the critical importance of monitoring the mental well-being of earthquake survivors.

背景/目标这项开创性的研究标志着对 2023 年阿尔哈乌兹地震后心理影响的初步探索。为了实现这一目标，研究人员通过标准化问卷系统地收集了人口统计学数据和焦虑/抑郁量表。42.01%的学生患有抑郁症，其中 84.80%为女性，59.65%年龄在 20 岁以下，88.89%为本科生。值得注意的是，心理健康护士（MHN）专业的学生是受影响最小的群体（RR = 0.3455，p < 0.05）。在有抑郁症病史的学生中，抑郁症的发病率明显更高（RR = 1.5227，p < 0.05）。在学生群体中，地震对因房屋无法居住或可能不安全而撤离的学生（63.14%）、遭受财产损失的学生（27.17%）和失去家人的学生（9.58%）的影响最为明显。焦虑影响了 37.59% 的学生。值得注意的是，焦虑与直接受灾害影响的学生（RR = 1.4836，p = 0.0036）以及被迫撤离家园的学生（RR = 1.7663，p = 0.0001）有统计学关联。此外，39.42% 的人表示有一种即将发生的恐惧感，30.3% 的人表现出担忧，并经常伴有安静和不活跃的行为（57.8%）、恐惧感和紧张的胃部（21.7%）。

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引用次数: 0

Health for all in India: A vision made possible through integrated Public Health and Community Medicine 印度全民健康：通过整合公共卫生和社区医疗实现愿景

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-09 DOI: 10.1016/j.cegh.2024.101807

Manisha Nitin Gore , Sneha Deepak Mallya

引用次数: 0

From dysbiosis to disease: Tracing gut microbiota's role in neonatal sepsis 从菌群失调到疾病：追踪肠道微生物群在新生儿败血症中的作用

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-08 DOI: 10.1016/j.cegh.2024.101809

Faiza Iqbal , Padmaja A. Shenoy , N. Siva , K.E. Vandana , Jayashree Purkayastha , Leslie Edward S. Lewis

Introduction

Neonatal sepsis remains a critical health issue, contributing significantly to morbidity and mortality among preterm infants. Dysbiosis, an imbalance in gut microbiota, is increasingly recognized as a key factor influencing the susceptibility to sepsis. This study aims to elucidate these associations by tracing gut microbiota development in preterm neonates.

Method

ology: A prospective cohort study was conducted at a tertiary care hospital in Karnataka, India, involving 182 preterm neonates (gestational age <37 weeks, birth weight <1500 g) from January 2021 to September 2023. Two cohorts were defined: Cohort 1 (Healthy neonates) and Cohort 2 (Neonates with sepsis). Stool samples were collected on day 4 and day 14 for microbiological analysis. Conventional culture techniques were used to identify bacterial isolates.

Results

The study included 182 neonates, equally divided between two cohorts. On Day 4, Cohort 1 had 45 % E. coli and 44 % Klebsiella pneumoniae, which decreased to 40.7 % and 40.7 % by Day 14, respectively. Conversely, Bifidobacterium spp. increased from 30.8 % to 52.7 %. Cohort 2 exhibited higher persistence of pathogenic bacteria, with Klebsiella pneumoniae increasing from 70.3 % to 74.7 % and E. coli from 38.5 % to 51.6 %. Mode of delivery significantly influenced gut flora, with NVD linked to higher beneficial bacteria prevalence (Enterococcus faecalis and Bifidobacterium spp.).

Conclusion

The study highlights significant differences in gut microbial patterns between healthy and sepsis neonates, emphasizing the role of initial gut colonization in neonatal health outcomes. Factors such as delivery mode and prenatal antibiotic exposure significantly impact gut microbiota composition, influencing infection susceptibility.

导言新生儿败血症仍然是一个严重的健康问题，严重影响了早产儿的发病率和死亡率。肠道微生物菌群失调被认为是影响败血症易感性的关键因素。本研究旨在通过追踪早产新生儿肠道微生物群的发展来阐明这些关联：一项前瞻性队列研究于 2021 年 1 月至 2023 年 9 月在印度卡纳塔克邦的一家三级护理医院进行，涉及 182 名早产新生儿（胎龄 37 周，出生体重 1500 克）。共定义了两个队列：队列 1（健康新生儿）和队列 2（患有败血症的新生儿）。第 4 天和第 14 天采集粪便样本进行微生物分析。研究包括 182 名新生儿，平均分为两组。第 4 天，第 1 组中大肠杆菌和肺炎克雷伯菌的比例分别为 45% 和 44%，到第 14 天分别降至 40.7% 和 40.7%。相反，双歧杆菌却从 30.8% 增加到 52.7%。组群 2 的致病菌持续率较高，肺炎克雷伯菌从 70.3% 增加到 74.7%，大肠杆菌从 38.5% 增加到 51.6%。分娩方式对肠道菌群的影响很大，NVD 与较高的有益菌（粪肠球菌和双歧杆菌）流行率有关。分娩方式和产前抗生素暴露等因素会对肠道微生物群的组成产生重大影响，从而影响感染的易感性。

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引用次数: 0

Childhood cerebral malaria: Pattern of biochemical parameters and clinical outcome in a Nigerian tertiary hospital 儿童脑型疟疾：尼日利亚一家三级医院的生化指标模式和临床结果

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-08 DOI: 10.1016/j.cegh.2024.101786

Ayobami Oyetunji Alabi , Olanike Taye Oladibu , Samson Aderemi Ojedokun , Abraham Ifeoluwa Akinbola , Taiwo Wulemot Oloyede , Bukola Adetutu Sayomi

Background

The outcome of children with cerebral malaria involves an interplay of factors including clinical and biochemical parameters, a deep knowledge of these laboratory biochemical parameters is essential. Thus, this study aimed to assess the pattern of the biochemical parameters in children with cerebral malaria and how it may affect the clinical outcomes.

Methods

A prospective observational cohort study among fifty subjects at the children's emergency unit. The participants were children aged 6 months to 12 years admitted with a history of fever and altered sensorium, demonstrable malaria parasite in the blood film and cerebrospinal fluid (CSF) analysis not suggestive of central nervous system (CNS) infections. Detailed history was taken with thorough examinations of each child. Samples were collected for malaria parasites, serum electrolytes, urea, creatinine, and blood glucose values. The clinical outcomes were correlated with the analyte levels.

Results

60 % of the children survived without any sequelae with the highest proportion (70 %) of survivors being children above five years. Children with hypoglycemia had a 3.5-fold higher risk of poor outcomes and this is statistically significant (RR = 3.65 p = 0.014). Hyperkalaemia was significantly associated with poor outcomes (RR = 2.57, p = 0.009). Subjects with hypochloraemia had three times the risk of poor outcome and mortality with statistically significant association (RR = 3.07, χ² = 8.519, p = 0.004). There was a significant association between metabolic acidosis and poor clinical outcome. (RR = 1.99, χ² = 4.089, p = 0.043). The parasite density was significantly associated with the serum bicarbonate (HCO₃⁻) and Chloride, p-value < 0.05.

Conclusion

Hypoglycaemia, hyperkalemia, hypochloremia and metabolic acidosis were significantly associated with poor outcomes, thus, good predictors of clinical outcomes in children diagnosed with cerebral malaria. Periodic evaluation and monitoring of these parameters is essential for prompt intervention to forestall devastating outcomes.

背景脑疟疾患儿的预后涉及临床和生化指标等多种因素的相互作用，因此深入了解这些实验室生化指标至关重要。因此，本研究旨在评估脑型疟疾患儿的生化指标模式及其对临床结果的影响。研究对象为 6 个月至 12 岁的儿童，入院时有发热和感觉改变的病史，血片中有明显的疟原虫，脑脊液（CSF）分析未提示中枢神经系统（CNS）感染。详细询问病史并对每个儿童进行全面检查。采集样本检测疟原虫、血清电解质、尿素、肌酐和血糖值。结果60%的儿童存活下来，没有留下任何后遗症，其中五岁以上儿童的存活率最高（70%）。患低血糖症的儿童出现不良后果的风险比正常儿童高 3.5 倍，这在统计学上有显著意义（RR = 3.65 p = 0.014）。高钾血症与不良预后显著相关（RR = 2.57，p = 0.009）。低氯血症受试者的不良预后和死亡风险是正常人的三倍，且有统计学意义（RR = 3.07，χ2 = 8.519，P = 0.004）。代谢性酸中毒与不良临床预后之间存在明显关联。(RR = 1.99，χ2 = 4.089，p = 0.043）。结论高血糖、高钾血症、低氯血症和代谢性酸中毒与不良预后显著相关，因此是诊断为脑疟疾的儿童临床预后的良好预测因素。定期评估和监测这些参数对于及时干预以避免破坏性后果至关重要。

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引用次数: 0

Adherence to antiretroviral therapy among HIV patients at a hospital in Tacna, Peru 秘鲁塔克纳一家医院的艾滋病患者坚持抗逆转录病毒治疗的情况

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-08 DOI: 10.1016/j.cegh.2024.101803

Brayan Miranda-Chavez , Monica Mejia-Copaja , Alvaro Taype-Rondan

Objective

This study aims to provide an overview of antiretroviral therapy adherence and its related factors within a hospital in southern Peru.

Materials and methods

We conducted an analytical cross-sectional study spanning from April to October 2022. This study involved a review of medical records and the administration of a survey to individuals living with Human Immunodeficiency Virus. Adherence to antiretroviral treatment was assessed using the CEAT-HIV (Questionnaire for the Evaluation of Antiretroviral Treatment Adherence), and was categorized as high, adequate, insufficient, or low. The statistical analysis included the calculation of crude and adjusted prevalence ratios (PRs).

Results

Our study comprised 300 participants, with a median age of 30 years, predominantly male (78.3 %). Among these individuals, 83 % exhibited low or insufficient adherence to antiretroviral treatment according to the CEAT-VIH scale. Notably, patients with a viral load >50,000 copies/ml scored higher on the CEAT-VIH scale than those with a viral load <400 (adjusted PR: 2.78, 95 % CI: 1.21 to 6.40). Furthermore, a higher level of education and a viral load below 400 copies/ml were associated to higher scores in the treatment compliance dimension of the CEAT-VIH scale.

Conclusion

Eight out of ten evaluated patients exhibited low or insufficient adherence. While lower adherence was correlated with lower education, the connection between viral load and adherence remains inconclusive.

材料与方法我们在 2022 年 4 月至 10 月期间开展了一项横断面分析研究。这项研究包括审查医疗记录和对人类免疫缺陷病毒感染者进行调查。使用 CEAT-HIV（抗逆转录病毒治疗依从性评估问卷）评估抗逆转录病毒治疗的依从性，并将其分为 "高"、"足够"、"不足 "或 "低"。统计分析包括计算粗略患病率比（PRs）和调整患病率比（PRs）。结果我们的研究有 300 名参与者，中位年龄为 30 岁，以男性为主（78.3%）。根据 CEAT-VIH 量表，其中 83% 的患者对抗逆转录病毒治疗的依从性较低或不足。值得注意的是，病毒载量为 50,000 拷贝/毫升的患者在 CEAT-VIH 量表上的得分高于病毒载量为 400 拷贝/毫升的患者（调整后 PR：2.78，95 % CI：1.21 至 6.40）。此外，教育程度越高、病毒载量低于 400 copies/ml 的患者在 CEAT-VIH 量表的治疗依从性维度上得分越高。虽然较低的依从性与较低的教育程度相关，但病毒载量与依从性之间的关系仍不确定。

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引用次数: 0

Hyper fibrinolysis state in COVID 19 and its correlation to lipid parameters COVID 19 中的高纤维蛋白溶解状态及其与血脂参数的相关性

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-08 DOI: 10.1016/j.cegh.2024.101811

Abhilash Sharma , Anupama Hegde , Nandini M. , Sowndarya K. , Rukmini M.S. , Ashok Prabhu K.

Background

Coronavirus disease 2019 (COVID 19) is associated with systemic effects involving especially the respiratory and cardiovascular system. The unique features of this condition are disseminated intravascular coagulation, excess fibrin degradation products due to abnormality in the coagulation system that could independently predict mortality. Abberations in lipid parameters that normally predict cardiovascular disease (CVD) were compared with D-dimer levels as risk markers in patients with COVID 19.

Methods

A hospital based cross sectional study was conducted over a period of five months in patients aged 30–70 years diagnosed with COVID-19. The patients were categorised based on the D-dimer levels as: Group I < 0.5 μg/ml (Normal), Group II 0.5–2.0 μg/ml (Intermediate high), Group III >2.0 μg/ml (Very high). The lipid parameters, atherogenic indices were compared between the three groups.

Results

The mean age of the selected COVID-19 patients was 49.3 ± 19.1 years of which 63 were males and 37 females (2:1). Significantly high D-dimer levels were detected which had a weak positive correlation with TG, Atherogenic Index Plasma (AIP). Significant rise in TC, LDL and Non-HDL was seen in Group II. Increasing trend of AIP was seen across the groups. D-dimer showed a weak positive correlation with TG, AIP and statistically non-significant negative correlation with rest of the lipid parameters.

Conclusion

Though an overall increase in D-dimer, TG and AIP was observed in COVID-19 patients, categorization based on D-dimer status detected lowering LDL and increasing AIP on deterioration of disease state.

背景科罗纳病毒病 2019（COVID 19）与全身影响有关，尤其涉及呼吸系统和心血管系统。这种疾病的独特之处在于弥散性血管内凝血，凝血系统异常导致纤维蛋白降解产物过多，可独立预测死亡率。我们将通常可预测心血管疾病（CVD）的血脂参数异常与作为 COVID-19 患者风险标志物的 D-二聚体水平进行了比较。方法我们对 30-70 岁确诊为 COVID-19 的患者进行了为期 5 个月的医院横断面研究。根据 D-二聚体水平将患者分为以下几组：第一组为 0.5 μg/ml（正常），第二组为 0.5-2.0 μg/ml（中高），第三组为 2.0 μg/ml（极高）。结果所选 COVID-19 患者的平均年龄为 49.3 ± 19.1 岁，其中男性 63 人，女性 37 人（2:1）。D-二聚体水平明显偏高，与总胆固醇、血浆致动脉粥样硬化指数（AIP）呈弱正相关。第二组的总胆固醇、低密度脂蛋白和非高密度脂蛋白明显升高。各组的 AIP 均呈上升趋势。结论虽然在 COVID-19 患者中观察到 D-二聚体、TG 和 AIP 整体上升，但根据 D-二聚体状态进行分类，发现 LDL 下降，AIP 上升，这与疾病状态恶化有关。

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引用次数: 0

Role of KIM-1 in early diagnosis of contrast-induced nephropathy following invasive cardiac procedure: A systematic review KIM-1 在有创心脏手术后造影剂诱发肾病的早期诊断中的作用：系统综述

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-08 DOI: 10.1016/j.cegh.2024.101765

Mantasha Shuaib , Md Masoom , Mohd Ashif Khan

This systematic review aims to provide a comprehensive analysis of the diagnostic efficacy of KIM-1 in CI-AKI. We evaluated its potential as a robust biomarker for the early identification and prediction of AKI progression.

Methodology

To assess KIM-1 as a biomarker for CI-AKI, relevant databases were searched. Inclusion criteria comprised studies measuring KIM-1 levels in patients undergoing cardiac procedures with contrast media and data were extracted. Methodological quality and bias were evaluated using Quadas-2 tool.

Conclusion

KIM-1 shows promise as a biomarker for renal injury. Its upregulation, correlation with injury severity, and involvement in tissue repair support its clinical relevance.

Prospero registration number

CRD42023431419.

本系统综述旨在全面分析 KIM-1 在 CI-AKI 中的诊断功效。为了评估 KIM-1 作为 CI-AKI 生物标志物的潜力，我们检索了相关数据库。纳入标准包括在使用造影剂进行心脏手术的患者中测量 KIM-1 水平的研究，并提取数据。结论KIM-1有望成为肾损伤的生物标记物。KIM-1的上调、与损伤严重程度的相关性以及对组织修复的参与支持了其临床相关性。

引用次数: 0

Exploring the association between household sanitation and women’s menstrual hygiene management in rural Odisha, India 探索印度奥迪沙农村地区家庭卫生与妇女经期卫生管理之间的关系

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-08 DOI: 10.1016/j.cegh.2024.101804

Manas Ranjan Behera , Ranjit Kumar Dehury , Deepanjali Behera , Bhuputra Panda

Introduction

Access to water, sanitation, and hygiene (WASH) facilities has been globally recognized as a critical need, especially for women and girls to ensure their menstrual hygiene. This study aimed to investigate the association between household sanitation and women's menstrual management experience in Odisha, India.

Methods

A cross-sectional study was conducted in Balasore district of Odisha state in India among 694 rural women and girls aged 15–45 years selected using a multi-stage sampling method. The Performance Monitoring and Accountability (PMA) 2020 questionnaire was used for data collection. Multivariate logistic regression analysis was carried out using SPSS version 25.

Results

More than two-third (68.4 %) of rural families used improved sanitary facilities. Around 30 % of households have been using an unimproved sanitary facility, which means the practice of open defecation is still prevalent in rural areas. About 40.6 % of women and girls reported using clothes as their primary menstrual hygiene material. Further, women and girls with improved sanitation facilities (aOR = 1.56, 95 % CI: 1.09–2.59) were more likely to change menstrual materials at the main household sanitation facility than those with an unimproved sanitation facility. In contrast, households using improved sanitation facility were less likely to use bedroom/sleeping areas to change the menstrual materials (aOR = 0.65, 95 % CI: 0.42–0.99) than those with an unimproved facility.

Conclusion

Availability of improved household sanitation is critical to good menstruation management practices. State-specific policy for menstrual health and hygiene could provide the much-needed impetus to strengthen WASH infrastructure in rural and tribal regions of Odisha.

导言：获得水、环境卫生和个人卫生（WASH）设施已被全球公认为是一项关键需求，尤其是对妇女和女童而言，以确保她们的经期卫生。本研究旨在调查印度奥迪沙邦家庭卫生设施与妇女月经管理经验之间的关系。方法在印度奥迪沙邦巴拉索尔地区，采用多阶段抽样方法对 694 名 15-45 岁的农村妇女和女孩进行了横断面研究。数据收集采用了 "2020 年绩效监测与问责（PMA）"问卷。结果超过三分之二（68.4%）的农村家庭使用改良卫生设施。约 30% 的家庭一直在使用未经改良的卫生设施，这意味着露天排便的做法在农村地区仍然普遍存在。约 40.6%的妇女和女孩称，衣服是她们主要的经期卫生用品。此外，与卫生设施未得到改善的家庭相比，卫生设施得到改善的妇女和女孩（aOR = 1.56，95 % CI：1.09-2.59）更有可能在家庭主要卫生设施处更换经期卫生用品。相比之下，使用改良卫生设施的家庭与使用未改良卫生设施的家庭相比，使用卧室/睡眠区更换经期用品的可能性较低（aOR = 0.65，95 % CI：0.42-0.99）。针对各邦的月经健康和卫生政策可为加强奥迪沙邦农村和部落地区的讲卫生运动基础设施提供急需的动力。

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引用次数: 0

Association of socioeconomic status with unintended pregnancy and induced abortion in married couples: An analysis of the 2021 national survey data in Japan 社会经济地位与已婚夫妇意外怀孕和人工流产的关系：日本 2021 年全国调查数据分析

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-06 DOI: 10.1016/j.cegh.2024.101814

Tasuku Okui

Background

An association of the major indicators of socioeconomic status with unintended pregnancy and induced abortion in married couples has not been investigated in Japan, and we investigated it using recent nationwide survey data in Japan.

Methods

Data from the National Fertility Survey in 2021 in Japan, which evaluated the outcomes and intentions of previous pregnancies in married couples, were used. Number of unintended pregnancies, induced abortions, and unintended pregnancies ending in induced abortion was used as outcomes, and the number of unintended pregnancies ending in induced abortion was analyzed among couples who experienced an unintended pregnancy. Associations with current educational attainment, employment status, and household income were investigated using Poisson regression analysis. A complete-case analysis was conducted for dealing with missing data, as well as an analysis using multiple imputation.

Results

The average number of unintended pregnancy and induced abortion per pregnancy of junior high school graduates was the highest among educational attainments of wives and husbands. The adjusted regression analysis showed that junior high school graduate in husbands was significantly associated with higher number of unintended pregnancies and induced abortions, regardless of the missing data analysis methods. In addition, high school or training school graduate in husbands was significantly associated with higher number of induced abortions. A significant association between socioeconomic status and the unintended pregnancy ending in induced abortion was not observed.

Conclusion

This study showed that a lower educational attainment in husband was associated with higher number of unintended pregnancies and induced abortions in Japan.

背景日本尚未研究过社会经济地位的主要指标与已婚夫妇意外怀孕和人工流产的关系，我们利用日本最近的全国性调查数据进行了研究。方法我们使用了2021年日本全国生育率调查的数据，该调查评估了已婚夫妇之前怀孕的结果和意向。意外怀孕次数、人工流产次数和以人工流产告终的意外怀孕次数作为结果，以人工流产告终的意外怀孕次数在经历过意外怀孕的夫妇中进行分析。使用泊松回归分析法调查了与当前教育程度、就业状况和家庭收入的关系。结果在妻子和丈夫的教育程度中，初中毕业生意外怀孕和人工流产的平均次数最高。调整后的回归分析显示，无论采用哪种缺失数据分析方法，丈夫的初中毕业学历都与较高的意外怀孕和人工流产次数显著相关。此外，高中或培训学校毕业的丈夫与人工流产次数较多也有明显关系。结论本研究表明，在日本，丈夫的教育程度越低，意外怀孕和人工流产的数量就越高。

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引用次数: 0

Exploring the gut microbiota of rural region of Haryana (India): sociodemographic, socioeconomic factors and lifestyle 探索哈里亚纳邦（印度）农村地区的肠道微生物群：社会人口、社会经济因素和生活方式

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health

Pub Date : 2024-10-05 DOI: 10.1016/j.cegh.2024.101806

Suchandra Gupta , Manisha Khandait , Sandhya Khunger

Background

The normal gut microbiota serves numerous functions in our body, which includes metabolism of food and drugs, maintenance of integrity of mucosal barrier and also protection against pathogens. Various factors are responsible in designing the structure of gut microbiota such as diet, lifestyle, sociodemographic and socioeconomic factors. The aim of the research was to study the composition of gut microbiota of individuals from rural regions of Haryana and to understand the impact of sociodemographic factors, lifestyle, and socioeconomic status on the diversity of gut microbiota.

Methods

A cross-sectional study was conducted on 200 healthy individuals from rural region of Haryana, data pertaining to their socioeconomic and sociodemographic factors, lifestyle and diet was recorded through a questionnaire, followed by the processing of stool samples by both culture-dependent and independent techniques.

Results

Out of the 200 samples, the abundance of phylum Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria were found. High alpha diversity with less beta diversity was observed. High counts of Lactobacillus, Bifidobacterium and Prevotella were found among males, whereas among females high abundance of Fusobacterium, Streptococcus, Enterococcus and E.coli were found. Occupation wise we found increased abundance of Bifidobacterium, Clostridium, Bacteroides, Rhuminicoccus and Salmonella in homemakers, whereas among employed subjects abundance of Lactobacillus and Yersinia were increased. Presence of butyrate producing bacteria (Bifidobacterium and Lactobacillus) among the subjects with sufficient sleep was also recorded.

Conclusion

While comparing the association of gut microbiota with various sociodemographic factors, we found differences in the phylum abundance, but statistically it was nonsignificant. Whereas positive association was observed between gut microbiota and healthy lifestyle which includes consumption of balanced diet, non smokers, sufficient water intake and good quality of sleep.

背景正常的肠道微生物群在人体内发挥着多种功能，包括食物和药物的新陈代谢、维护粘膜屏障的完整性以及抵御病原体。设计肠道微生物群结构的因素有很多，如饮食、生活方式、社会人口和社会经济因素。本研究旨在研究哈里亚纳邦农村地区个体的肠道微生物群组成，并了解社会人口因素、生活方式和社会经济状况对肠道微生物群多样性的影响。方法对来自哈里亚纳邦农村地区的 200 名健康人进行了横断面研究，通过问卷调查记录了他们的社会经济和社会人口因素、生活方式和饮食习惯等相关数据，然后通过依赖培养技术和独立技术处理粪便样本。观察到α多样性较高，β多样性较低。男性中乳酸杆菌、双歧杆菌和普雷沃特氏菌的数量较高，而女性中镰刀菌、链球菌、肠球菌和大肠杆菌的数量较高。从职业角度看，我们发现家庭主妇中的双歧杆菌、梭状芽孢杆菌、乳酸杆菌、Rhuminicoccus 和沙门氏菌的数量增加，而就业者中的乳酸杆菌和耶尔森氏菌的数量增加。结论在比较肠道微生物群与各种社会人口学因素的关联时，我们发现了菌门丰度的差异，但在统计学上并不显著。而肠道微生物群与健康的生活方式（包括均衡饮食、不吸烟、充足的水摄入量和良好的睡眠质量）之间存在正相关。

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引用次数: 0