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Association between carotenoid intake and periodontitis in diabetic patients. 类胡萝卜素摄入量与糖尿病患者牙周炎之间的关系。
IF 2.5 Q3 NUTRITION & DIETETICS Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI: 10.1017/jns.2023.116
Fengli Li, Ge Wang, Yujie Zhang

This study aimed to evaluate the association between dietary carotenoid intake and periodontitis in diabetic patients. Data on diabetic patients were collected from the National Health and Nutrition Examination Survey (NHANES) 2009-2014 for this cross-sectional study. Dietary intake of carotenoids was assessed through the first 24-hour dietary recall interview. Full-mouth periodontal examinations were conducted by trained dental examiners. Subgroup analysis was conducted in terms of age, gender, the number of missing teeth, cardiovascular disease, smoking, and anti-diabetic drugs. Totally 1914 diabetic patients were included, with 1281 (66.93%) in the periodontitis group. After adjusting for age, gender, race, education, smoking, dental implants, hepatitis, and the number of missing teeth, α-carotene intake ≥55.82 mcg was associated with lower odds of periodontitis than α-carotene intake <55.82 mcg [OR = 0.70, 95% CI: 0.53-0.91, P = 0.010]; lutein and zeaxanthin intake ≥795.95 mcg was associated with decreased odds of periodontitis than lutein and zeaxanthin intake <795.95 mcg (OR = 0.75, 95%CI: 0.57-0.98, P = 0.039). The association between carotenoid intake and periodontitis varied across different subpopulations. In diabetes, dietary intake of α-carotene and lutein and zeaxanthin was inversely associated with the odds of periodontitis, which may facilitate clinical periodontitis management.

本研究旨在评估糖尿病患者膳食类胡萝卜素摄入量与牙周炎之间的关系。这项横断面研究从2009-2014年美国国家健康与营养调查(NHANES)中收集了糖尿病患者的数据。类胡萝卜素的膳食摄入量通过首次24小时膳食回忆访谈进行评估。全口牙周检查由经过培训的牙科检查员进行。根据年龄、性别、缺失牙齿数量、心血管疾病、吸烟和抗糖尿病药物等因素进行了分组分析。共纳入 1914 名糖尿病患者,其中牙周炎组有 1281 人(66.93%)。在对年龄、性别、种族、教育程度、吸烟、种植牙、肝炎和缺牙数量进行调整后,α-胡萝卜素摄入量≥55.82微克与牙周炎发生几率比α-胡萝卜素摄入量低相关(P = 0.010];叶黄素和玉米黄质摄入量≥795.95微克与牙周炎发生几率比叶黄素和玉米黄质摄入量低相关(P = 0.039)。类胡萝卜素摄入量与牙周炎之间的关系在不同亚人群中存在差异。在糖尿病患者中,α-胡萝卜素、叶黄素和玉米黄质的膳食摄入量与牙周炎的几率成反比,这可能有助于临床牙周炎的治疗。
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引用次数: 0
Erratum: Indian adolescents' perceptions of anaemia and its preventive measures: A qualitative study - ERRATUM. 勘误:印度青少年对贫血及其预防措施的看法:定性研究 - ERRATUM.
IF 2.5 Q3 NUTRITION & DIETETICS Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI: 10.1017/jns.2024.12
Neha Rathi, Sangeeta Kansal, Aryan Raj, Nikitha Pedapanga, Immanuel Joshua, Anthony Worsley

[This corrects the article DOI: 10.1017/jns.2024.4.].

[此处更正了文章 DOI:10.1017/jns.2024.4.]。
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引用次数: 0
Indian adolescents' perceptions of anaemia and its preventive measures: Aqualitative study. 印度青少年对贫血及其预防措施的看法:定量研究。
IF 2.5 Q3 NUTRITION & DIETETICS Pub Date : 2024-02-16 eCollection Date: 2024-01-01 DOI: 10.1017/jns.2024.4
Neha Rathi, Sangeeta Kansal, Aryan Raj, Nikitha Pedapanga, Immanuel Joshua, Anthony Worsley

High prevalence of anaemia is a severe public health problem in several low- and middle-income countries like India. A qualitative inquiry was designed to understand the perceptions of adolescents regarding anaemia and anaemia prevention measures. Convenience sampling was employed to recruit 39 adolescents (19 girls; 20 boys) from Tikari, India. Interviews were carried out in the local language, audio-recorded and transcribed verbatim. Hemoglobin concentration was also assessed from a single drop of capillary blood using the HemoCue, and the participants were asked to share their Science/Biology and Home Science textbooks. Interview data was analysed thematically. Descriptive statistics were used to examine the distributions of the hemoglobin data while textbooks were analysed using content analysis to verify the coverage of anaemia and anaemia-related matter. Seven themes were identified: (i) Poor understanding of the term anaemia; (ii) Minimal discussion about anaemia in classroom; (iii) Limited knowledge about symptoms of anaemia; (iv) Limited awareness about prevention and cure of anaemia; (v) Perception of iron folic acid and deworming tablets among students; (vi) Lack of contribution of health workers in the prevention of anaemia; (vii) No knowledge of 'Anemia free India' programme. More than half of the sample had anaemia (16.7% mild anaemia, 33.3% moderate anaemia, 2.8% severe anaemia). Content analysis revealed that there was limited discussion about anaemia in both Home Science and Science textbooks. Behavioural interventions should focus on inculcating healthy culinary and dietary practices and addressing the gaps in knowledge and understanding of anaemia and its prevention among adolescents.

在印度等一些中低收入国家,贫血症的高发病率是一个严重的公共卫生问题。为了了解青少年对贫血和贫血预防措施的看法,我们设计了一项定性调查。研究采用便利抽样的方法,从印度蒂卡里招募了 39 名青少年(19 名女孩;20 名男孩)。访谈以当地语言进行,并进行录音和逐字记录。此外,还使用 HemoCue 对一滴毛细血管血液中的血红蛋白浓度进行了评估,并要求参与者分享他们的科学/生物学和家政学教科书。对访谈数据进行了专题分析。描述性统计用于检查血红蛋白数据的分布情况,而教科书则采用内容分析法进行分析,以核实贫血和与贫血相关的内容的覆盖面。确定了七个主题(i) 对 "贫血症 "一词理解不深;(ii) 课堂上对贫血症的讨论极少;(iii) 对贫血症症状的了解有限;(iv) 对贫血症的预防和治疗认识不足;(v) 学生对叶酸铁和驱虫药片的认识不足;(vi) 卫生工作者在预防贫血症方面的贡献不足;(vii) 对 "无贫血印度 "计划一无所知。一半以上的样本患有贫血症(16.7%轻度贫血,33.3%中度贫血,2.8%重度贫血)。内容分析显示,家政学和科学教科书中关于贫血症的讨论都很有限。行为干预措施应侧重于灌输健康的烹饪和饮食习惯,解决青少年对贫血及其预防的认识和理解方面的差距。
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引用次数: 0
A scoping review of dietary assessment questionnaires potentially suitable for assessing habitual dietary intake in the National Health and Nutrition Survey, Japan. 对日本全国健康与营养调查中可能适用于评估习惯性膳食摄入量的膳食评估问卷的范围审查。
IF 2.4 Q3 NUTRITION & DIETETICS Pub Date : 2024-02-12 eCollection Date: 2024-01-01 DOI: 10.1017/jns.2024.1
Mai Matsumoto, Kentaro Murakami, Xiaoyi Yuan, Fumi Oono, Riho Adachi, Ryoko Tajima, Emiko Okada, Makiko Nakade, Satoshi Sasaki, Hidemi Takimoto

This scoping review aimed to identify questionnaire-based dietary assessment methods for use in the National Health and Nutrition Survey (NHNS) in Japan. The search was conducted in three databases (PubMed, Web of Science, and Ichushi) to identify questionnaire such as food frequency questionnaire and dietary history questionnaire validated against dietary recalls or food records for the intakes of both food groups and nutrients among Japanese adults. Study quality was assessed based on previously developed criteria. We extracted the questionnaire characteristics and the design and results of the validation studies. We identified 11 questionnaires, with the number of food items ranging from 40 to 196, from 32 articles of good quality. In the validation studies, participants were aged 30-76 years and 90% of the articles used ≥3 d dietary records as reference. The number of nutrients and food groups with a group-level intake difference within 20% against the reference method ranged from 1 to 30 and 1 to 11, respectively. The range of mean correlation coefficients between questionnaire and reference methods were 0.35-0.57 for nutrients and 0.28-0.52 for food groups. When selecting a survey instrument in the NHNS from the 11 existing questionnaires identified in this study, it is important to select one with high group-level comparison and correlation coefficient values on the intended assessment items after scrutinizing the design and results of the validation study. This review may serve as a reference for future studies that explore dietary assessment tools used for assessing dietary intake in specific representative populations.

本范围综述旨在确定日本国民健康与营养调查(NHNS)中使用的基于问卷的膳食评估方法。我们在三个数据库(PubMed、Web of Science 和 Ichushi)中进行了检索,以确定根据膳食回顾或食物记录对日本成年人的食物类别和营养素摄入量进行验证的问卷,如食物频率问卷和膳食史问卷。研究质量根据之前制定的标准进行评估。我们提取了问卷的特点以及验证研究的设计和结果。我们从 32 篇质量较好的文章中确定了 11 份调查问卷,食物种类从 40 种到 196 种不等。在验证研究中,参与者的年龄在 30-76 岁之间,90% 的文章使用≥3 天的膳食记录作为参考。与参考方法相比,组间摄入量差异在20%以内的营养素和食物组的数量分别为1至30种和1至11种。营养素的问卷调查与参考方法的平均相关系数范围为 0.35-0.57,食物类别的平均相关系数范围为 0.28-0.52。当从本研究确定的 11 份现有问卷中选择国家健康与营养调查的调查工具时,重要的是在仔细研究验证研究的设计和结果后,选择一份在预定评估项目上具有较高组别比较和相关系数值的问卷。本综述可为今后探讨用于评估特定代表性人群膳食摄入量的膳食评估工具的研究提供参考。
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引用次数: 0
Erratum: Potassium intake is associated with nutritional quality and actual diet cost: a study at formulating a low sodium high potassium (LSHP) healthy diet - CORRIGENDUM. 勘误:钾摄入量与营养质量和实际膳食成本相关:关于制定低钠高钾 (LSHP) 健康膳食的研究 - CORRIGENDUM。
IF 2.5 Q3 NUTRITION & DIETETICS Pub Date : 2024-02-08 eCollection Date: 2024-01-01 DOI: 10.1017/jns.2024.3
Farapti Farapti, Annas Buanasita, Dominikus R Atmaka, Stefania W Setyaningtyas, Merryana Adriani, Purwo S Rejeki, Yoshio Yamaoka, Muhammad Miftahussurur

[This corrects the article DOI: 10.1017/jns.2021.104.].

[此处更正了文章 DOI:10.1017/jns.2021.104.]。
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引用次数: 0
Barriers and facilitators to consuming pulses: a qualitative exploration including effects of trying recipes at home. 食用豆类的障碍和促进因素:定性探索,包括在家尝试食谱的效果。
IF 2.5 Q3 NUTRITION & DIETETICS Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.1017/jns.2023.119
B Whittall, S M Warwick, M Jackson, K M Appleton

Pulses are a healthy, sustainable, low cost food, but consumption levels are low for a variety of reasons, including practical and cooking concerns. This work aimed to explore barriers and facilitators towards pulse consumption and increasing consumption, and the potential value of cooking suggestions and recipes for changing these perceptions. Two qualitative studies were undertaken. In Study 1, 21 participants (10 males, 11 females, of a range of ages, cooking responsibilities, and experiences with pulses) were interviewed both before and after receiving cooking suggestions and recipes. In Study 2, 12 participants (2 males, 10 females, as above) were interviewed once after trying recipes. Interviews were audio-recorded, transcribed, and analysed using thematic analysis. Seven themes described barriers and facilitators towards pulse consumption: 'Enjoyment and Sensory properties'; 'Benefits and Recommendations'; 'Practical Concerns'; 'Cooking Concerns'; 'Compatibility with current diet'; 'Personal Influences'; and 'External Influences'. Some similar themes also referred to increasing consumption: 'Willingness'; 'Awareness, Knowledge of Benefits'; 'Knowledge of Cooking and Practical Concerns'; and 'Compatibility with current diet'. Cooking suggestions and recipe use resulted in themes on 'Awareness'; 'Willingness, Trying New Things'; 'Small Changes'; and facilitators associated with 'Enjoyment, Sensory Properties, Practical Concerns, Benefits' and 'Knowledge, Cooking Ideas and Confidence, Incorporation, Cooking Solutions'. Barriers related to 'Risk and Preconceptions'; 'Awareness, but' inaction and additional considerations were also found. Our findings demonstrate a positive role for pulse consumption for increased experience, familiarity, and confidence with preparing, cooking, and consuming these healthy and sustainable foods.

豆类是一种健康、可持续、低成本的食品,但由于各种原因,包括实际操作和烹饪方面的顾虑,豆类的消费水平很低。这项工作旨在探索豆类消费和增加消费的障碍和促进因素,以及烹饪建议和食谱对改变这些观念的潜在价值。我们开展了两项定性研究。在研究 1 中,21 名参与者(10 名男性,11 名女性,年龄、烹饪责任和豆类经验各不相同)在接受烹饪建议和食谱之前和之后接受了访谈。在研究 2 中,12 名参与者(2 男 10 女,同上)在尝试食谱后接受了一次访谈。对访谈进行了录音、转录和主题分析。七个主题描述了食用脉搏的障碍和促进因素:"享受和感官特性"、"益处和建议"、"实际问题"、"烹饪问题"、"与当前饮食的兼容性"、"个人影响 "和 "外部影响"。一些类似的主题也提到了增加消费:"意愿";"意识、对益处的了解";"烹饪知识和实际顾虑";以及 "与当前饮食的兼容性"。烹饪建议和食谱的使用产生了 "意识"、"意愿、尝试新事物"、"微小变化 "等主题,以及与 "享受、感官特性、实际问题、益处 "和 "知识、烹饪想法和信心、融入、烹饪解决方案 "相关的促进因素。此外,还发现了与 "风险和成见"、"意识"、"不行动 "和额外考虑有关的障碍。我们的研究结果表明,食用豌豆对增加准备、烹饪和食用这些健康和可持续食品的经验、熟悉程度和信心具有积极作用。
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引用次数: 0
Determinants of lifestyle and body weight status among breast cancer survivors with overweight/obesity and perspectives towards the development of weight loss interventions: a qualitative study with health professionals from Greece. 患有超重/肥胖症的乳腺癌幸存者中生活方式和体重状况的决定因素以及对制定减肥干预措施的看法:与希腊卫生专业人员开展的定性研究。
IF 2.4 Q3 NUTRITION & DIETETICS Pub Date : 2024-01-23 eCollection Date: 2024-01-01 DOI: 10.1017/jns.2023.117
Georgios Saltaouras, Maria Perperidi, Dimitra Vantzou, Konstantina Vatsina, Emmanouil Saloustros, Yannis Theodorakis, Odysseas Androutsos

The current study assessed the views and attitudes of health professionals (HPs) regarding factors associated with energy balance-related health behaviours and weight management in breast cancer survivors (BCS) with overweight and obesity. Semi-structured online interviews were conducted with 21 HPs (oncologists, dietitians- nutritionists, physical education instructors, mental health professionals, and nurses) from Attica and Thessaly. Thematic analysis was used to analyse and present the data. Four main themes arose from the data: "The patients' mental health wellbeing", "Survivors' interest in diet and exercise", "Interdisciplinary collaboration in patient's care", and "Maintaining normality". HPs agreed that weight loss in BCS with overweight and obesity is important, but negative mental health wellbeing is a main barrier to behaviour change. For many BCS their cancer diagnosis is a "teachable" moment for weight management, especially for women of younger age, who are more keen to discuss weight management issues. Essential characteristics that determine/facilitate behavioural change include education, commitment for regular communication, personalised intervention, and interdisciplinary collaboration. According to HPs, future weight loss interventions should take into account BCS's mental health wellbeing and level of motivation and should provide regular support and education.

本研究评估了医疗卫生专业人员(HPs)对与能量平衡相关的健康行为和体重管理因素的看法和态度,这些因素涉及超重和肥胖的乳腺癌幸存者(BCS)。我们对来自阿提卡和塞萨利的 21 名医护人员(肿瘤学家、营养师、体育教师、心理健康专业人员和护士)进行了半结构化在线访谈。采用主题分析法对数据进行分析和展示。数据产生了四个主要专题:"患者的心理健康"、"幸存者对饮食和运动的兴趣"、"患者护理中的跨学科合作 "和 "保持正常状态"。医疗保健人员一致认为,对于超重和肥胖的 BCS 来说,减轻体重非常重要,但消极的心理健康是改变行为的主要障碍。对许多 BCS 来说,癌症诊断是体重管理的 "可教 "时刻,尤其是对年轻女性来说,她们更热衷于讨论体重管理问题。决定/促进行为改变的基本特征包括教育、定期沟通的承诺、个性化干预和跨学科合作。根据保健人员的意见,未来的减肥干预措施应考虑到 BCS 的心理健康和动机水平,并应提供定期支持和教育。
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引用次数: 0
Virgin coconut oil (VCO) supplementation relieves symptoms and inflammation among COVID-19 positive adults: a single-blind randomized trial. 补充初榨椰子油(VCO)可缓解 COVID-19 阳性成人的症状和炎症:单盲随机试验。
IF 2.4 Q3 NUTRITION & DIETETICS Pub Date : 2024-01-23 eCollection Date: 2024-01-01 DOI: 10.1017/jns.2023.118
Imelda Angeles-Agdeppa, Jacus S Nacis, Fabian M Dayrit, Keith V Tanda

A clinical study conducted in 2020 showed that virgin coconut oil (VCO) has been found effective in the rapid relief of COVID-19 symptoms and normalization of the C-reactive protein (CRP) concentration among probable and suspected cases of COVID-19. This present study aimed to validate those results and to evaluate the effects of VCO among COVID-19 patients through a 28-day randomized, single-blind trial conducted among 76 SARS-CoV-2 RT-PCR (reverse transcription-polymerase chain report)-confirmed adults, with VCO given as a COVID-19 adjunct therapy. The results showed that VCO recipients were free from symptoms and had normal CRP concentrations by day 14. In comparison, participants in the control group reported relief from signs and symptoms on day 23, with normal CRP concentrations on day 25. This second study bolsters the use of VCO as an effective adjunct therapy for COVID-19-positive patients showing mild-to-moderate symptoms.

2020 年进行的一项临床研究表明,初榨椰子油(VCO)可有效快速缓解 COVID-19 症状,并使 COVID-19 疑似病例的 C 反应蛋白(CRP)浓度恢复正常。本研究旨在验证这些结果,并通过对 76 名经 SARS-CoV-2 RT-PCR(反转录聚合酶链式反应报告)确诊的成人进行为期 28 天的随机单盲试验,评估 VCO 在 COVID-19 患者中的效果,并将 VCO 作为 COVID-19 的辅助疗法。结果表明,VCO 受试者在第 14 天时已无症状,CRP 浓度正常。相比之下,对照组的受试者在第 23 天时体征和症状有所缓解,第 25 天时 CRP 浓度正常。第二项研究证明,VCO 是治疗 COVID-19 阳性患者轻度至中度症状的有效辅助疗法。
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引用次数: 0
The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysis 维生素 K 补充剂对心血管风险因素的影响:系统回顾和荟萃分析
IF 2.5 Q3 NUTRITION & DIETETICS Pub Date : 2024-01-11 DOI: 10.1017/jns.2023.106
Qiu-Yan Zhao, Qiu Li, Minoo Hasan Rashedi, Mohammadhassan Sohouli, Pejman Rohani, Periyannan Velu
Abstract Cardiovascular disease (CVD) is one of the most important diseases which controlling its related risk factors, such as metabolic and inflammatory biomarkers, is necessary because of the increased mortality risk of that. The aim of our meta-analysis is to reveal the general effect of vitamin K supplementation on its related risk factors. Original databases were searched using standard keywords to identify all randomized clinical trials (RCTs) investigating the effects of vitamin K on CVD. Pooled weighted mean difference (WMD) and 95 % confidence intervals (95 % CI) were achieved by random-model effect analysis for the best estimation of outcomes. The statistical heterogeneity was determined using the Cochran's Q test and I2 statistics. Seventeen studies were included in this systematic review and meta-analysis. The pooled findings showed that vitamin K supplementation can reduce homeostatic model assessment insulin resistance (HOMA-IR) (WMD: −0⋅24, 95 % CI: −0⋅49, −0⋅02, P = 0⋅047) significantly compared to the placebo group. However, no significant effect was observed on other outcomes. Subgroup analysis showed a significant effect of vitamin K2 supplementation compared to vitamin K1 supplementation on HOMA-IR. However, no significant effect was observed on other variables. Also, subgroup analysis showed no potential effect of vitamin K supplementation on any outcome and omitting any articles did not affect the final results. We demonstrated that supplementation with vitamin K has no effect on anthropometrics indexes, CRP, glucose metabolism, and lipid profile factors except HOMA-IR.
摘要 心血管疾病(CVD)是最重要的疾病之一,控制其相关风险因素(如代谢和炎症生物标志物)是必要的,因为这会增加死亡风险。我们的荟萃分析旨在揭示维生素 K 补充剂对相关风险因素的总体影响。我们使用标准关键词检索了原始数据库,以确定所有研究维生素 K 对心血管疾病影响的随机临床试验(RCT)。通过随机模型效应分析得出汇总加权平均差(WMD)和95%置信区间(95% CI),以获得对结果的最佳估计。统计异质性采用 Cochran's Q 检验和 I2 统计。本次系统综述和荟萃分析共纳入 17 项研究。汇总结果显示,与安慰剂组相比,维生素 K 补充剂可显著降低胰岛素抵抗稳态模型评估(HOMA-IR)(WMD:-0⋅24,95 % CI:-0⋅49,-0⋅02,P = 0⋅047)。但对其他结果没有观察到明显影响。亚组分析显示,与维生素 K1 补充剂相比,维生素 K2 补充剂对 HOMA-IR 有明显影响。但对其他变量未观察到明显影响。此外,亚组分析表明,维生素 K 补充剂对任何结果都没有潜在影响,省略任何文章都不会影响最终结果。我们的研究表明,补充维生素 K 对人体测量指标、CRP、糖代谢和除 HOMA-IR 以外的血脂概况因素没有影响。
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引用次数: 0
The relationship between caffeine and its metabolites and bone mineral density in postmenopausal women: a cross-sectional analysis from the NHANES database 绝经后妇女体内咖啡因及其代谢物与骨矿物质密度之间的关系:来自 NHANES 数据库的横断面分析
IF 2.5 Q3 NUTRITION & DIETETICS Pub Date : 2024-01-08 DOI: 10.1017/jns.2023.98
Sheng Liao, Jianhong Zhou, Hui Chen, Wei Wei, Feng Ye, Yidong Zhang, Zhongrong Zhang
Abstract We aim to explore the association between caffeine and its metabolites and bone mineral density (BMD) in postmenopausal women. Data of 4286 postmenopausal women were extracted from the National Health and Nutrition Examination Survey (NHANES) database in 2009–14 in this cross-sectional study. Weighted linear regression and stepwise regression analyses were used to screen the covariates. Weighted univariate and multivariate linear regression analyses were used to explore the associations between caffeine and its metabolites and BMD. The evaluation index was estimated value (β) with 95 % confidence intervals (CIs). We also explored these relationships in age subgroups. The median BMD level among the eligible women was 0⋅7 gm/cm2. After adjusting for covariates including age, body mass index (BMI), fat intake, Calcium (Ca) supplements, diabetes mellitus (DM), angina pectoris, parental history of osteoporosis (OP), anti-osteoporosis therapy, poverty income ratio (PIR), vitamin D (VD) supplements, coronary heart disease (CHD), and previous fracture, we found that caffeine intake was not significantly related to the BMD reduction (β = 0, P = 0⋅135). However, caffeine metabolites, including MethyluricAcid3, MethyluricAcid7, MethyluricAcid37, Methylxanthine3, and Methylxanthine37, were negatively associated with the BMD (all P < 0⋅05). In addition, MethyluricAcid37 and Methylxanthine37 were negatively associated with BMD in females aged <65 years old, while MethyluricAcid3 and Methylxanthine3 were noteworthy in those who aged ≥65 years old. The roles of caffeine and its metabolites in BMD reduction and OP in postmenopausal women needed further exploration.
摘要 我们旨在探讨咖啡因及其代谢物与绝经后妇女骨矿物质密度(BMD)之间的关系。这项横断面研究从 2009-14 年美国国家健康与营养调查(NHANES)数据库中提取了 4286 名绝经后妇女的数据。采用加权线性回归和逐步回归分析筛选协变量。加权单变量和多变量线性回归分析用于探讨咖啡因及其代谢物与 BMD 之间的关系。评价指标为估计值 (β),置信区间为 95%。我们还在年龄分组中探讨了这些关系。符合条件的妇女的 BMD 水平中位数为 0⋅7 gm/cm2。在调整了包括年龄、体重指数 (BMI)、脂肪摄入量、钙 (Ca) 补充剂、糖尿病 (DM)、心绞痛、父母骨质疏松症 (OP)、抗骨质疏松症治疗、贫困收入比 (PIR)、维生素 D (VD) 补充剂、冠心病 (CHD) 和既往骨折在内的协变量后,我们发现咖啡因摄入量与 BMD 下降无显著关系(β = 0,P = 0⋅135)。然而,咖啡因代谢物,包括甲基尿酸3、甲基尿酸7、甲基尿酸37、甲基黄嘌呤3和甲基黄嘌呤37与骨密度呈负相关(所有P < 0⋅05)。此外,MethyluricAcid37 和 Methylxanthine37 与年龄小于 65 岁的女性的 BMD 呈负相关,而 MethyluricAcid3 和 Methylxanthine3 与年龄大于 65 岁的女性的 BMD 呈显著相关。咖啡因及其代谢物在绝经后妇女的 BMD 减少和 OP 中的作用需要进一步探讨。
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Journal of Nutritional Science
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