Contemporary societies face slow-burning crises – such as antimicrobial resistance (AMR) – that demand sustained responses from national governments but often elicit uneven action. Policy implementation, public health, and creeping crisis literatures have each proposed factors to explain why governments vary in their responses. This article brings together these different factors and examines their ability to explain levels of government action. Focusing on the case of AMR, it draws on existing literature to theorise different factors which together may determine levels of government response to this pressing crisis. It then employs qualitative comparative analysis to test the extent to which these proposed factors, alone or in combination, produce sufficient or insufficient government responses to AMR. The analysis finds that proposed factors related to public attention and societal dependencies do not appear to affect government response in this case, with government capacity standing out as a key deciding factor. These findings contribute both to efforts to tackle AMR and to broader research on the determinants of effective crisis management.