Adapting to the remote working environment has been one of the most visible challenges for many organizations during the COVID-19 pandemic. As employee creativity helps organizations' survival and resilience during times of crisis, this study aims to examine the role of leadership communication, family-supportive leadership communication in particular, in fostering creativity among work-from-home employees. The current study specifically focuses on the mediating processes in this relationship and the moderating role of employees' work-life segmentation preferences, using a survey of 449 employees who have worked from home during the COVID-19 outbreak. The results showed that employee-organization relationship (EOR) quality, positive affect, and work-life enrichment mediate the relationship between family-supportive leadership communication and employee creativity. The effects of family-supportive leadership communication on employees' positive affect and work-life enrichment were more prominent for those who prefer to segment their work and lives. This paper concludes with a discussion of the theoretical and practical implications of these findings for leadership in organizational communication.