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Cutback management strategies and citizen evaluation of government 削减管理策略与政府公民评价
IF 3.5 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-06-30 DOI: 10.1111/padm.12947
Carla Flink, Xiaoyang Xu
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引用次数: 1
Shaping influence in governance networks: The role of motivations and information exchange 治理网络的影响塑造:动机和信息交换的作用
IF 3.5 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-06-21 DOI: 10.1111/padm.12942
J. Reyes-Gonzalez, F. Agneessens, M. Esteve
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引用次数: 0
What motivates users to report service‐related issues? A study on coproduction in a smart public service 是什么促使用户报告与服务相关的问题？智能公共服务中的协同生产研究
IF 3.5 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-06-21 DOI: 10.1111/padm.12946
A. P. Rodriguez Müller, Amandine Lerusse, T. Steen, S. Van de Walle
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引用次数: 0
Co-treatment of Naringenin and Ketoprofen-RGD Suppresses Cell Proliferation via Calmodulin/PDE/cAMP/PKA Axis Pathway in Leukemia and Ovarian Cancer Cells. 柚皮苷和酮洛芬-RGD 共同作用可通过钙调蛋白/PDE/cAMP/PKA 轴通路抑制白血病和卵巢癌细胞的增殖
IF 1.6 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-06-19 eCollection Date: 2023-01-01 DOI: 10.5812/ijpr-136131
Havva Afshari, Shokoofe Noori, Bahareh Shokri, Afshin Zarghi

Background: Naringenin (Nar) has anti-inflammatory and anticarcinogenic properties. Arginine-glycine- aspartate (RGD) is a tripeptidic sequence used as an integrin ligand and targeting system for delivering chemotherapeutic agents to cancer cells.

Objectives: In this study, the inhibitory effects of Nar and ketoprofen-RGD on leukemia and ovarian cancer cells (K562 and SKOV3) were explored for the first time, focusing on their proliferation activity and their anti-inflammatory capacity.

Methods: Analyses were conducted on the calmodulin (CaM)-dependent phosphodiesterase 1 (PDE1) activation by ketoprofen-RGD, Nar, and their combination. These drugs' effects on protein kinase A (PKA) activation, intracellular cyclic adenosine monophosphate (cAMP) level, and PDE1 inhibition were identified. Later, it was also evaluated if ketoprofen-RGD alone or in combination with Nar had anti-inflammatory effects.

Results: Nar improved the antagonizing consequences of ketoprofen-RGD on the CaM protein, which hinders PDE1, improving PKA activity and cAMP levels. A mixture of ketoprofen-RGD and Nar and ketoprofen-RGD alone diminished K562 and SKOV3 cell viability through the cAMP/PKA pathway by inhibiting PDE1 and CaM. These two compounds showed anti-inflammatory effects on both cell lines.

Conclusions: This study indicated for the first time that combining ketoprofen-RGD and Nar can be a promising anti-inflammatory therapeutic regimen for treating leukemia and ovarian cancer.

背景：柚皮苷（Nar）具有抗炎和抗癌特性。精氨酸-甘氨酸-天冬氨酸（RGD）是一种三肽序列，可作为整合素配体和靶向系统将化疗药物输送到癌细胞中：本研究首次探讨了纳尔和酮洛芬-RGD对白血病和卵巢癌细胞（K562和SKOV3）的抑制作用，重点研究了它们的增殖活性和抗炎能力：方法：分析了酮洛芬-RGD、纳尔和它们的组合对钙调素（CaM）依赖性磷酸二酯酶1（PDE1）的激活作用。确定了这些药物对蛋白激酶 A（PKA）活化、细胞内环磷酸腺苷（cAMP）水平和 PDE1 抑制作用的影响。随后，还评估了酮洛芬-RGD单独或与纳尔合用是否具有抗炎作用：结果：Nar改善了酮洛芬-RGD对阻碍PDE1的CaM蛋白的拮抗作用，提高了PKA活性和cAMP水平。酮洛芬-RGD和Nar的混合物以及单独的酮洛芬-RGD通过抑制PDE1和CaM，通过cAMP/PKA途径降低了K562和SKOV3细胞的活力。这两种化合物对两种细胞株都有抗炎作用：这项研究首次表明，酮洛芬-RGD 和纳尔联合使用可成为治疗白血病和卵巢癌的一种很有前景的抗炎疗法。
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引用次数: 0
What does the evidence tell us about merit principles and government performance? 关于功绩原则和政府绩效，证据告诉我们什么？
IF 3.5 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-06-13 DOI: 10.1111/padm.12945
Eloy H. S. Oliveira, Gordon Abner, Shinwoo Lee, Kohei Suzuki, Hyunkang Hur, J. Perry
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引用次数: 2
Permanently provisional: An ethnographic analysis of responsive governance practices in and through meetings 永久临时性：对会议中和通过会议采取的回应性治理做法的民族志分析
IF 3.5 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-06-12 DOI: 10.1111/padm.12943
E. Visser
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引用次数: 0
Buying green in U.S. local government: Internal commitment and responsiveness to external pressures 在美国地方政府购买绿色产品：内部承诺和对外部压力的反应
IF 3.5 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-06-06 DOI: 10.1111/padm.12944
A. Dimand, M. Neshkova
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引用次数: 1
Seeing the nudge from the trees: The 4S framework for evaluating nudges 从树中看到轻推:评估轻推的4S框架
IF 3.5 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-05-30 DOI: 10.1111/padm.12941
Stuart Mills, R. Whittle
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引用次数: 2
Unpacking hybridity: Development and first validation of a multidimensional instrument to profile hybrid professionals 拆解混杂:开发和首次验证的多维工具，以分析混合专业人士
2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-05-29 DOI: 10.1111/padm.12938
Amelia Compagni, Paola Roberta Boscolo, Giorgio Giacomelli, Marco Sartirana
Abstract Hybrid professionals, that is, professionals who have transitioned to managerial roles, have emerged in numerous public settings. Through in‐depth qualitative methodologies, the literature has shown a good degree of heterogeneity in the way hybrid professionals perceive and manage their hybridity. In this study, we aim to develop a theory‐based, multidimensional instrument able to capture such heterogeneity in a lean but sensitive way. In this instrument, we combine consolidated scales of identity centrality and integration and vignettes, on the one hand, to measure the perception of hybrid professionals of the relationship between their professional and managerial identities and, on the other hand, to elicit the practices they use to deal with the demands of the professional and managerial logics. We first validate the instrument on a sample of school principals in the Italian context and then describe the six profiles of hybrid professionals derived from the analysis. We suggest three avenues for applying such an instrument.
摘要混合专业人士，即过渡到管理角色的专业人士，已经出现在许多公共环境中。通过深入的定性方法，文献显示了混合专业人员感知和管理其混合性的方式的良好程度的异质性。在这项研究中，我们的目标是开发一种基于理论的多维工具，能够以精益但敏感的方式捕捉这种异质性。在这个工具中，我们结合了身份中心性、整合和小情节的综合量表，一方面衡量混合专业人士对其专业和管理身份之间关系的感知，另一方面，引出他们用来处理专业和管理逻辑需求的实践。我们首先在意大利的学校校长样本上验证了该工具，然后描述了从分析中得出的混合专业人士的六种概况。我们建议应用这种工具的三个途径。
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引用次数: 0
Creating a public service topology: Mapping public service motivation, public service ethos, and public service values 创建公共服务拓扑:映射公共服务动机、公共服务精神和公共服务价值
IF 3.5 2区 管理学 Q1 POLITICAL SCIENCE
Public Administration
Pub Date : 2023-05-23 DOI: 10.1111/padm.12939
Eva M. Witesman, Lawrence C. Walters, R. Christensen
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引用次数: 3
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