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‘The best spin’: Discourses of vaping intoxication, pleasure, and ‘poisoning’ “最好的谎言”:关于电子烟中毒、愉悦和“中毒”的论述。
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-10-07 DOI: 10.1016/j.drugpo.2025.105024
L.L. Wynn , Chloe Barron , Kirsten Bell , Helen Keane
Anti-tobacco public health campaigns portray e-cigarettes and cigarettes as interchangeable nicotine-delivery systems, describing ‘vapes’ as a gateway to combustible tobacco use. Some vape users, however, portray vaping as producing a qualitatively different drug experience, describing the pursuit of fleeting, dizzy moments of intoxication sometimes described as ‘head spins’. Recent anti-vape campaigns have seized upon the language of head spins, describing it as a symptom of nicotine poisoning, a portrayal at odds with vape users’ phenomenological accounts of vaping experiences. Framings of vaping experiences that reduce the pleasures of vaping to a poison effect fail to explain how and why young people are drawn to vaping. We need empirical understandings of drug experiences to inform public health policy, which means listening to users and how they phenomenologically describe their embodied drug experiences. We therefore undertook a qualitative study of 24 young people, both vape users and nonusers. We found that the intoxicating effect described as `head spins’ is actively sought by vape users who see it as a distinguishing aspect of high-nicotine content vapes, compared to combustible cigarettes. Often using neuropharmacological terminology to describe the nicotine experience, participants infused jargon such as ‘dopamine’ and ‘tolerance’ with their own embodied experiences of the temporality and pleasures of vape use. Our participants described ‘head spins’ as repeatedly visiting a state of fleeing intoxication to both transform and cope with everyday life.
反烟草公共卫生运动将电子烟和卷烟描述为可互换的尼古丁输送系统,将“电子烟”描述为使用可燃烟草的门户。然而,一些电子烟使用者将电子烟描述为产生一种质的不同的药物体验,他们描述了对短暂的,眩晕的陶醉时刻的追求,有时被称为“头晕目眩”。最近的反电子烟运动抓住了头昏的说法,将其描述为尼古丁中毒的一种症状,这与电子烟使用者对电子烟体验的现象学描述不符。将吸电子烟的乐趣降低到有毒效果的说法无法解释年轻人是如何以及为什么被吸电子烟吸引的。我们需要对药物体验的经验理解来为公共卫生政策提供信息,这意味着倾听使用者的意见,以及他们如何从现象上描述他们具体的药物体验。因此,我们对24名年轻人进行了定性研究,包括电子烟使用者和非使用者。我们发现,与可燃香烟相比,电子烟使用者积极寻求被称为“头晕”的陶醉效果,他们认为这是高尼古丁含量电子烟的一个显著特征。参与者经常使用神经药理学术语来描述尼古丁的体验,他们把“多巴胺”和“耐受性”等术语融入到他们自己对使用电子烟的短暂性和快感的具体体验中。我们的参与者将“头晕”描述为反复进入一种逃离醉酒的状态,以改变和应对日常生活。
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引用次数: 0
Trends in accidental drug overdose mortality in Canada: An analysis from 1974 to 2023 加拿大意外药物过量死亡趋势:1974年至2023年的分析。
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-10-06 DOI: 10.1016/j.drugpo.2025.105022
Harika Dasari , Adelina Artenie , Julie Bruneau , Sarah Larney

Background

Overdose deaths in Canada have been rising since 2016, but long-term trends remain poorly characterized. We examined national overdose mortality trends from 1974 to 2023 and explored differences by sex, age, and province.

Methods

We conducted a retrospective analysis of accidental and undetermined‐intent poisoning deaths in the Canadian Vital Statistics Death Database, calculating crude mortality rates (CMR) using Statistics Canada population estimates. We used segmented regression to model temporal trends and calculated average annual percentage change (AAPC) for each resulting segment. Analyses were stratified by sex, age (<25, 25–44, 45–64, and ≥65), and province.

Results

Between 1974 and 2023, 80,944 overdose deaths were recorded. Segmented regression of CMR revealed three phases: a period of relative stability (AAPC: -0.28 %; 1974–1991), followed by two accelerations (AAPC: 5.46 %; 1991–2013 and AAPC: 12 %; 2013–2023) CMRs were similar by sex until 2013–15, then surged in both males (AAPC: 13.81 %; 2012–2023) and females (AAPC: 9.32 %; 2015–2023). Rates in youth (<25) were stable until the early 2000s, then rose sharply (AAPC: 30.62 %; 2014–2017) before slowing, while rates among adults aged 25–44 (AAPC: 13.59 %; 2012–2023), 45–64 (AAPC: 11.56 %; 2014–2023), and ≥65 (AAPC: 18.48 %; 2020–2023) increased in recent years. Rates increased the most in Western provinces compared to Quebec and the Atlantic provinces.

Conclusions

Canada’s overdose epidemic reflects a segmented trajectory, with marked accelerations in 1996 and 2013, driven by healthcare practices, evolving drug markets, and social vulnerabilities. Regional and demographic disparities underscore the need for targeted, historically informed public health strategies.
背景:自2016年以来,加拿大的过量死亡人数一直在上升,但长期趋势仍然不明确。我们检查了1974年至2023年全国药物过量死亡率趋势,并探讨了性别、年龄和省份的差异。方法:我们对加拿大生命统计死亡数据库中的意外和不明意图中毒死亡进行了回顾性分析,使用加拿大统计局的人口估计值计算粗死亡率(CMR)。我们使用分段回归来模拟时间趋势,并计算每个结果段的平均年百分比变化(AAPC)。分析按性别、年龄分层(结果:1974年至2023年间,记录了80,944例过量死亡。CMR的分段回归显示了三个阶段:相对稳定期(AAPC: - 0.28%; 1974-1991),随后是两次加速期(AAPC: 5.46%; 1991-2013和AAPC: 12%; 2013-2023),直到2013-15年,性别CMR相似,然后男性(AAPC: 13.81%; 2012-2023)和女性(AAPC: 9.32%; 2015-2023) CMR均出现激增。结论:加拿大吸毒过量的流行反映了一个分段的轨迹,在1996年和2013年,受医疗保健实践、不断发展的毒品市场和社会脆弱性的推动,吸毒过量的趋势明显加速。区域和人口差异突出表明,需要制定有针对性的、了解历史情况的公共卫生战略。
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引用次数: 0
Conceptualizing cannabis grey markets: A typology based on the Uruguayan case 大麻灰色市场的概念化:基于乌拉圭案例的类型学。
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-10-05 DOI: 10.1016/j.drugpo.2025.105020
Lorena Repetto , Rosario Queirolo , Joaquín Alonso , Mafalda Pardal , Laura Atuesta , Beau Kilmer , Eliana Álvarez , Belén Sotto

Background and aims

The legalization of prohibited activities involves the creation of new (legal) markets that, in general, coexist with illegal markets. Legalization of cannabis in Uruguay was not the exception: it has generated a legal market but also promoted the emergence of new "grey" markets that operate in the intersection of legal and illegal markets. The purpose of this article is to conceptualize the grey markets accounting for its different subtypes, moving beyond a monolithic understanding.

Methods

This paper introduces a radial conceptualization for understanding cannabis grey markets, drawing on interviews with key informants including policymakers, academics, and stakeholders (n = 20), and interviews with people who frequently use cannabis (n = 50).

Results

Our findings suggest that in Uruguay there are at least three types of grey markets, which we categorize as light, standard, and dark grey. This classification stems from the illegal distribution of legally produced cannabis, which allows us to develop a typology based on two attributes: profitability and destination of the transaction. According to this typology, the light grey market involves non-profit sharing of legally grown cannabis within personal networks, primarily to cover production costs. The standard grey market includes small-scale, profit-oriented sales to a broader network of people who use cannabis. The dark grey market, on the other hand, refers to legally produced cannabis entering traditional illegal distribution channels to maximize profits.

Conclusions

Understanding the grey market's characteristics is essential for policymakers and regulators aiming to effectively legalize cannabis. Dark grey activities involve contact with the illegal market and contradict regulatory goals, prompting potential law enforcement actions. Conversely, the light grey resembles an informal market where cannabis is exchanged for goods or shared, likely acceptable to the government. Forbearance could apply to the standard grey market, although it may compete with legal markets. Assessing subtypes of grey markets contributes to a better understanding of the diverse interactions that occur within them and might enable policymakers to address each with tailored policy tools.
背景和目的:禁止活动的合法化涉及建立新的(合法)市场,这些市场通常与非法市场共存。乌拉圭的大麻合法化也不例外:它产生了一个合法市场,但也促进了在合法和非法市场交叉点上运作的新的“灰色”市场的出现。本文的目的是将灰色市场概念化,以解释其不同的子类型,而不是单一的理解。方法:本文通过对包括政策制定者、学者和利益相关者在内的关键线人(n = 20)的访谈,以及对经常使用大麻的人(n = 50)的访谈,介绍了一种了解大麻灰色市场的径向概念。结果:我们的研究结果表明,在乌拉圭至少有三种类型的灰色市场,我们将其分类为浅灰色、标准灰色和深灰色。这种分类源于合法生产的大麻的非法分销,这使我们能够根据两个属性开发一种类型:盈利能力和交易目的地。根据这种类型,浅灰色市场涉及在个人网络中非营利性地分享合法种植的大麻,主要是为了支付生产成本。标准的灰色市场包括向更广泛的大麻使用者网络进行小规模、以利润为导向的销售。另一方面,深灰色市场是指合法生产的大麻进入传统的非法分销渠道,以实现利润最大化。结论:了解灰色市场的特征对政策制定者和监管机构有效实现大麻合法化至关重要。深灰色活动涉及与非法市场的接触,与监管目标相抵触,可能会引发执法行动。相反,浅灰色类似于一个非正式的市场,在那里大麻被交换商品或共享,可能被政府接受。宽容适用于标准的灰色市场,尽管它可能与合法市场竞争。评估灰色市场的亚型有助于更好地了解其中发生的各种相互作用,并可能使政策制定者能够使用量身定制的政策工具来解决每一个问题。
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引用次数: 0
An analysis of scope, topics, methods and categories of drug policy research published in the International Journal of Drug Policy 毒品政策研究的范围、主题、方法和类别分析,发表在《国际毒品政策杂志》上
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-10-03 DOI: 10.1016/j.drugpo.2025.105026
Alison Ritter, Jonah Bunyon

Introduction

While the field of ‘drug policy research’ feels intuitively knowable, there are few papers examining drug policy as a research object, and exploring the different methods and categories of drug policy research. This paper aimed to provide such an analysis.

Methods

The data source was research papers published in the International Journal of Drug Policy in 2023 and 2024 (N = 453) as this journal was most likely to surface drug policy research as well as reflect the multiple disciplines that engage in this field of practice. We applied an operational definition of ‘drug policy research’: research where the object of study was a policy, or a policy process. For those papers coded as ‘Yes’ to this definition, we coded the policy topic, drug class and methods used, in addition to the category of policy research.

Results

Of the 453 papers, 34.4 % (n = 156) were coded as drug policy research, the majority of which concerned criminalisation, decriminalisation and legalisation (23.7 %, n = 37), with the second largest topic area being harm reduction policies (20.5 %, n = 32), followed by drug treatment policies (16.7 %, n = 26) and restrictions on sales, advertising, and price (17.9 %, n = 28). All major drug classes were covered. Of the 156 studies 48.7 % (n = 76) employed quantitative methods and 42.3 % (n = 66) employed qualitative methods. We worked with five categories of drug policy research: evaluation (studying policy outcomes & effects, 36.5 %); implementation (studying policy implementation, 22.4 %); mapping (documenting policy positions, 16 %); policy-making (studying policy formation, 14.1 %); and finally policy design (studying policy mechanisms, 10.9 %). Notable gaps included prevention policy research, and studies of methamphetamine, psychedelics, and illicit cannabis policies, as well as quantitative methods for mapping studies and qualitative methods for outcome studies.

Discussion

The chosen operational definition forecloses and stabilises drug policy research as a particular field of practice, with associated topics and methods. It circumscribes it to around 34 % of publications in IJDP over 2023 and 2024. If another journal (or dataset of drug research) was chosen, it may be larger or smaller and with differing primary topics and methods as well as spread across categories of policy research. Perhaps more importantly however, we highlight that ‘drug policy research’ can be made otherwise – discussing three alternative conceptualisations: as research that aims to inform policy, as street-level implementation, or as policy ecology – each of which boundary ‘drug policy research’ differently.
虽然“药物政策研究”这个领域让人感觉是直观可知的,但很少有论文将药物政策作为研究对象,并探讨药物政策研究的不同方法和类别。本文旨在提供这样的分析。方法数据来源为2023年和2024年发表在《国际药物政策杂志》(International Journal of Drug Policy)上的研究论文(N = 453),因为该杂志最可能涉及药物政策研究,并且反映了从事该领域实践的多学科。我们应用了“药物政策研究”的操作定义:研究的对象是一项政策,或一个政策过程。对于那些对这个定义表示“是”的论文,除了政策研究的类别外,我们还对政策主题、药物类别和使用的方法进行了编码。结果453篇论文中,34.4% (n = 156)被编码为药物政策研究,其中涉及犯罪化、非犯罪化和合法化的论文最多(23.7%,n = 37),其次是减少危害政策(20.5%,n = 32),其次是药物治疗政策(16.7%,n = 26)和对销售、广告和价格的限制(17.9%,n = 28)。所有主要的毒品类别都包括在内。156篇研究中,48.7% (n = 76)采用定量方法,42.3% (n = 66)采用定性方法。我们研究了五类药物政策研究:评估(研究政策结果和影响,36.5%);实施(研究政策实施,22.4%);绘图(记录政策立场,16%);政策制定(研究政策形成,14.1%);最后是政策设计(研究政策机制,10.9%)。显著的差距包括预防政策研究、对甲基苯丙胺、致幻剂和非法大麻政策的研究,以及测绘研究的定量方法和结果研究的定性方法。所选择的操作定义排除并稳定了药物政策研究作为一个特定的实践领域,以及相关的主题和方法。它规定在2023年和2024年期间,IJDP的出版物约占34%。如果选择其他期刊(或药物研究数据集),它可能更大或更小,并且具有不同的主要主题和方法,并且分布在不同的政策研究类别中。然而,也许更重要的是,我们强调了“药物政策研究”可以以其他方式进行——讨论了三种可供选择的概念:作为旨在为政策提供信息的研究,作为街道层面的实施,或者作为政策生态学——每一种都不同地界定了“药物政策研究”。
{"title":"An analysis of scope, topics, methods and categories of drug policy research published in the International Journal of Drug Policy","authors":"Alison Ritter,&nbsp;Jonah Bunyon","doi":"10.1016/j.drugpo.2025.105026","DOIUrl":"10.1016/j.drugpo.2025.105026","url":null,"abstract":"<div><h3>Introduction</h3><div>While the field of ‘drug policy research’ feels intuitively knowable, there are few papers examining drug policy as a research object, and exploring the different methods and categories of drug policy research. This paper aimed to provide such an analysis.</div></div><div><h3>Methods</h3><div>The data source was research papers published in the International Journal of Drug Policy in 2023 and 2024 (<em>N</em> = 453) as this journal was most likely to surface drug policy research as well as reflect the multiple disciplines that engage in this field of practice. We applied an operational definition of ‘drug policy research’: research where the object of study was a policy, or a policy process. For those papers coded as ‘Yes’ to this definition, we coded the policy topic, drug class and methods used, in addition to the category of policy research.</div></div><div><h3>Results</h3><div>Of the 453 papers, 34.4 % (<em>n</em> = 156) were coded as drug policy research, the majority of which concerned criminalisation, decriminalisation and legalisation (23.7 %, <em>n</em> = 37), with the second largest topic area being harm reduction policies (20.5 %, <em>n</em> = 32), followed by drug treatment policies (16.7 %, <em>n</em> = 26) and restrictions on sales, advertising, and price (17.9 %, <em>n</em> = 28). All major drug classes were covered. Of the 156 studies 48.7 % (<em>n</em> = 76) employed quantitative methods and 42.3 % (<em>n</em> = 66) employed qualitative methods. We worked with five categories of drug policy research: evaluation (studying policy outcomes &amp; effects, 36.5 %); implementation (studying policy implementation, 22.4 %); mapping (documenting policy positions, 16 %); policy-making (studying policy formation, 14.1 %); and finally policy design (studying policy mechanisms, 10.9 %). Notable gaps included prevention policy research, and studies of methamphetamine, psychedelics, and illicit cannabis policies, as well as quantitative methods for mapping studies and qualitative methods for outcome studies.</div></div><div><h3>Discussion</h3><div>The chosen operational definition forecloses and stabilises drug policy research as a particular field of practice, with associated topics and methods. It circumscribes it to around 34 % of publications in IJDP over 2023 and 2024. If another journal (or dataset of drug research) was chosen, it may be larger or smaller and with differing primary topics and methods as well as spread across categories of policy research. Perhaps more importantly however, we highlight that ‘drug policy research’ can be made otherwise – discussing three alternative conceptualisations: as research that aims to inform policy, as street-level implementation, or as policy ecology – each of which boundary ‘drug policy research’ differently.</div></div>","PeriodicalId":48364,"journal":{"name":"International Journal of Drug Policy","volume":"145 ","pages":"Article 105026"},"PeriodicalIF":4.4,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol’s harm to others: A new paradigm seeking its application 酒精对他人的伤害:寻求其应用的新范例
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-10-03 DOI: 10.1016/j.drugpo.2025.105018
Robin Room , Cassandra Hopkins , Anne-Marie Laslett
Research documenting the reach and varieties of alcohol’s harm to others than the person who drinks has emerged in the last 20 years, with studies in over 40 countries. Population surveys have asked respondents about harm to themselves or their children from others’ drinking. Staff of societal response agencies – police, hospitals, child protection agencies – have also been interviewed, along with studies of agency records and social cost analyses of alcohol’s harm to others.
While a few studies have compared cross-sectionally the relation between alcohol policies in countries or states and rates of specific harms from others’ drinking, analysis has been limited of how alcohol policies or other legal changes may reduce such rates. The new focus on alcohol’s harm to others has rarely been noticed in broader public health policy research. Neither has it received public notice; a study of the broad British newspaper discourse around minimum unit pricing policy for alcohol in Scotland found considerable mention of alcohol’s harm to others, but without any reference to the findings of the relevant research literature.
This paper reviews the situation and considers paths forward. One advance would be leveraging more data collection from the caseloads of health and other response agencies. For particular areas of harm, those controlling the relevant space need to be involved in the policy changes – e.g., employers and unions in workplaces. Alongside research on the prevalence, studies of policy change and related impacts on harm from others’ drinking, studies of policy processes and attitudes towards the harm to others paradigm amongst opinion leaders and the general public should be undertaken. To move public health interests in alcohol policy forward, alliances should be built, for example with women’s movements concerning harm to women from men’s drinking.
在过去的20年里,有研究记录了酒精对饮酒者以外的人的伤害范围和种类,在40多个国家进行了研究。人口调查向受访者询问了他人饮酒对自己或子女的伤害。还对社会应对机构——警察、医院、儿童保护机构——的工作人员进行了访谈,同时对机构记录进行了研究,并对酒精对他人造成的伤害进行了社会成本分析。虽然有一些研究横断面比较了国家或州的酒精政策与他人饮酒造成特定危害的比率之间的关系,但对酒精政策或其他法律变化如何降低这种比率的分析有限。在更广泛的公共卫生政策研究中,很少注意到酒精对他人危害的新关注点。它也没有收到公众的通知;一项关于苏格兰酒精最低单位定价政策的广泛英国报纸论述的研究发现,酒精对他人的伤害有相当大的提及,但没有提及任何相关研究文献的发现。本文对现状进行了回顾,并对今后的发展方向进行了思考。一项进展将是利用从卫生和其他应对机构的病例量中收集的更多数据。对于特定的危害领域,那些控制相关空间的人需要参与政策变化,例如,工作场所的雇主和工会。除了对患病率的研究外,还应研究政策变化及其对他人饮酒造成伤害的相关影响,研究政策进程以及意见领袖和公众对伤害他人范例的态度。为了推动酒精政策中的公共卫生利益,应建立联盟,例如与有关男子饮酒对妇女造成伤害的妇女运动建立联盟。
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引用次数: 0
Anti-doping measures in gyms and fitness centres: A mapping of practices in the state parties of the council of Europe’s anti-doping convention 健身房和健身中心的反兴奋剂措施:欧洲委员会反兴奋剂公约缔约国的做法图。
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-09-27 DOI: 10.1016/j.drugpo.2025.105025
Lambros Lazuras , Fredrik Lauritzen , Erik Duiven , Michael Petrou , Liene Kozlovska , Julien Attuil , Jamie Brown
The use of image and performance enhancement drugs (doping) in recreational sport presents an emerging public health challenge, but there is scarce research on current preventive measures. The present research was concerned with mapping and analysing anti-doping measures in gyms and fitness centres in countries that are State Parties to the Anti-Doping Convention of the Council of Europe. Using the Anti-Doping Questionnaire of the Council of Europe, we found that only 17 (35 %) of the 49 countries that participated in the study implemented measures to tackle doping among gym and fitness centre customers and staff, and 19 countries (39 %) included measures addressing the health consequences of doping use. In the majority (83 %) of countries that took any preventive measures against doping in gyms and fitness centres, National Anti-Doping Organisations (NADOs) were involved in their implementation. Further analysis indicated key areas where doping prevention measures have developed. The implications for policy and practice in doping prevention are discussed.
在休闲体育运动中使用提高形象和成绩的药物(兴奋剂)是一项新的公共卫生挑战,但目前对预防措施的研究很少。目前的研究涉及绘制和分析作为《欧洲委员会反兴奋剂公约》缔约国的国家的体育馆和健身中心的反兴奋剂措施。通过使用欧洲委员会的反兴奋剂调查问卷,我们发现参与研究的49个国家中只有17个(35%)实施了针对健身房和健身中心客户和员工使用兴奋剂的措施,19个国家(39%)采取了解决使用兴奋剂对健康后果的措施。在大多数(83%)对在健身房和健身中心使用兴奋剂采取预防措施的国家中,国家反兴奋剂组织(nado)参与了这些措施的实施。进一步的分析指出了兴奋剂预防措施已发展的关键领域。讨论了对兴奋剂预防政策和实践的影响。
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引用次数: 0
A brick to a bundle: A qualitative study of behavioral responses to xylazine adulteration 从一砖到一捆:对二甲苯掺假行为反应的定性研究。
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-09-27 DOI: 10.1016/j.drugpo.2025.105017
Adams L. Sibley , Colin W. Miller , Elizabeth Joniak-Grant , Alice Bell , Malcolm Visnich , Steve Alsum , Nabarun Dasgupta

Background

Xylazine, a veterinary tranquilizer, has emerged as a widespread adulterant in the U.S. illicit drug supply, detected in over 90 % of street fentanyl samples in some regions and identified in a growing number of overdose deaths. While xylazine's health risks are well-documented, little is known about how its presence influences substance use behaviors. We aimed to explore behavioral changes among people encountering xylazine in illicit drug markets.

Methods

We conducted semi-structured in-depth interviews with people with recent overdose reversal experiences in two Midwestern cities (n = 52) as part of a larger study on naloxone administration. Participants were asked about their knowledge and perceptions of local drug supply trends. Data were analyzed using the Rigorous and Accelerated Data Reduction technique. Protection Motivation Theory provided a theoretical framework.

Results

Participants overwhelmingly preferred opioids without xylazine. Almost all reported adjusting use toward safer practices in response to xylazine exposure: using less in amount or frequency, changing route of administration, or abstaining or seeking treatment. Behavior change was motivated by fear of negative outcomes, including physical health risks (particularly chronic wounds and limb loss), not experiencing intended opioid effects, loss of functionality due to unwanted sedation, and concerns about overdose reversibility.

Conclusion

Findings suggest that people who use drugs are adapting consumption patterns and adopting harm reduction practices as coping responses to xylazine's adverse effects. Unlike previous major opioid market transitions that primarily differed in pharmacokinetics, xylazine introduces new risks while replacing desired psychoactive effects with undesirable ones. The widespread dissatisfaction with xylazine represents a unique opportunity to expand harm reduction interventions and explore safe supply policies while risk salience is high and user motivation for safer practices aligns with public health goals.
背景:Xylazine是一种兽医镇静剂,在美国非法药物供应中已成为一种广泛的掺假物,在一些地区超过90%的街头芬太尼样本中检测到,并且在越来越多的过量死亡中被发现。虽然二甲肼的健康风险是有据可查的,但人们对它的存在如何影响药物使用行为知之甚少。我们的目的是探索在非法毒品市场上遇到噻嗪的人的行为变化。方法:作为纳洛酮给药更大研究的一部分,我们对中西部两个城市最近有过量逆转经历的人进行了半结构化的深度访谈(n= 52)。与会者被问及他们对当地药品供应趋势的了解和看法。数据分析使用严格和加速数据缩减技术。保护动机理论提供了理论框架。结果:绝大多数参与者更喜欢不含噻嗪的阿片类药物。几乎所有人都报告说,在暴露于噻嗪后,调整了更安全的使用方法:减少剂量或频率,改变给药途径,或放弃或寻求治疗。行为改变的动机是对负面结果的恐惧,包括身体健康风险(特别是慢性伤口和肢体丧失),没有经历预期的阿片类药物效应,由于不必要的镇静而导致的功能丧失,以及对过量可逆性的担忧。结论:研究结果表明,吸毒者正在适应消费模式,并采取减少危害的做法,以应对噻嗪的不良反应。与以往主要的阿片类药物市场转变主要在药代动力学方面不同,甲嗪在用不希望的精神活性作用取代期望的精神活性作用时引入了新的风险。对噻嗪的普遍不满为扩大减少危害干预措施和探索安全供应政策提供了独特的机会,同时风险高度突出,用户采用更安全做法的动机符合公共卫生目标。
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引用次数: 0
Choreographing, tailoring and dialoguing care in residential rehabilitation 住宅康复中的编排、剪裁和对话护理
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-09-22 DOI: 10.1016/j.drugpo.2025.104970
Ramez Bathish , Cameron Duff , Michael Savic
Alcohol and other drug residential rehabilitation is an abstinence-based modality for assisting people with long-standing concerns associated with their substance use. While ubiquitous, models of care in residential rehabilitation services vary widely and the impacts of the care delivered within them remain contentious. Critically, therapeutic processes in residential rehabilitation remain under-theorised with little attention given to the characteristics of “good care” within these settings. To examine this, an extended period of ethnographic fieldwork was conducted at one residential rehabilitation service in Eastern Australia, involving forty-one in-depth interviews with residents and staff, observations and documentary analysis. Drawing on critical accounts of care derived from science and technology studies, our analysis details how caring well in residential rehabilitation was enacted through repertoires of: tailoring care to the needs and preferences of individuals; choreographing care to attend to the multiple and diverse needs that circulate in residential rehabilitation; and dialoguing care to attune to the needs of those enmeshed in care relations. These repertoires also facilitated care by mitigating the totalising tendencies of institutional care, and enhancing meaningful engagement across the residential community, improving access to therapeutic resources that accrue in the program over time. This analysis emphasises the programmatic flexibility and complex, resource intensive relations necessary for the expression of “as-well-as-possible care”. It also alerts stakeholders to how systems of care both condition needs and enact vulnerabilities, challenging us to envisage new systems and relations to enable people to live better lives in accordance with their needs and preferences.
酒精和其他药物住院康复是一种以戒断为基础的方式,用于帮助与药物使用有关的长期担忧的人。虽然普遍存在,但住宅康复服务的护理模式差异很大,并且在其中提供的护理的影响仍然存在争议。关键的是,住院康复的治疗过程仍然缺乏理论化,很少关注这些环境中的“良好护理”特征。为了研究这一点,在东澳大利亚的一个住宅康复服务机构进行了一项长期的民族志实地调查,包括与居民和工作人员进行41次深入访谈,观察和文献分析。根据来自科学和技术研究的护理的关键账户,我们的分析详细说明了如何通过一系列措施来制定良好的住院康复护理:根据个人的需求和偏好量身定制护理;精心设计护理,以满足住宅康复中多种多样的需求;通过对话来协调那些陷入护理关系的人的需求。这些曲目还通过减轻机构护理的总体趋势,增强整个住宅社区的有意义的参与,改善获得治疗资源的机会,从而促进护理。这种分析强调了方案的灵活性和复杂的资源密集型关系,这是表达“尽可能照顾”所必需的。它还提醒各利益攸关方注意,护理系统既会造成需求,也会造成脆弱性,要求我们设想新的系统和关系,使人们能够根据自己的需求和偏好过上更好的生活。
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引用次数: 0
The brain disease model of addiction and epistemic injustice 成瘾和认知不公正的脑疾病模型
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-09-22 DOI: 10.1016/j.drugpo.2025.105015
Shane O’Mahony
The brain disease model of addiction (BDMA) is a dominant, if highly contested, model of drug addiction globally. Over many decades, researchers have marshalled evidence from animal studies, neuroimaging scans, and genome wide association studies to argue that addiction is a brain disease. However, critics have argued that the model de-emphasises social and economic contexts, downplays the phenomenon of spontaneous or natural recovery, and over-interprets neuroscientific findings. Building on this critical tradition, the current paper asks a related question: Has the claim that addiction is a brain disease helped or harmed those experiencing drug-related harm epistemically? While no definitive answer to this question is offered, the current paper argues that overall, the claim that addiction is a brain disease advanced by proponents of the BDMA has harmed substance users already experiencing multiple disadvantages epistemically.
Drawing on the concept of epistemic injustice, the current paper argues that the category ‘drugs’ creates an artificial and harmful dichotomy between those who use licit medicines and experience harm and those who use illicit substances and experience harm. Furthermore, this artificial dichotomy is compounded by racist and colonial discourses central to the war on drugs, and a rigid biological reductionism that de-emphasises social, economic, and cultural harm. The paper concludes by sketching an alternative approach rooted in epistemic justice, and a discussion of the implications of this concept for research and theory.
脑疾病成瘾模型(BDMA)是一个占主导地位的,如果高度争议,全球药物成瘾模型。几十年来,研究人员从动物研究、神经成像扫描和全基因组关联研究中收集证据,证明成瘾是一种脑部疾病。然而,批评人士认为,该模型淡化了社会和经济背景,淡化了自发或自然恢复的现象,并过度解释了神经科学的发现。基于这一批判传统,当前的论文提出了一个相关的问题:成瘾是一种脑部疾病的说法在认知上是帮助还是伤害了那些经历毒品相关伤害的人?虽然这个问题没有明确的答案,但目前的论文认为,总的来说,BDMA的支持者提出的成瘾是一种脑部疾病的说法,已经在认知上伤害了已经经历了多重不利的物质使用者。根据认知不公正的概念,本文认为,“药物”这一类别在使用合法药物并遭受伤害的人和使用非法药物并遭受伤害的人之间制造了一种人为的有害二分法。此外,这种人为的二分法还与以毒品战争为中心的种族主义和殖民主义话语以及不强调社会、经济和文化危害的严格的生物还原论相结合。本文最后概述了一种基于认知正义的替代方法,并讨论了这一概念对研究和理论的影响。
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引用次数: 0
Reluctant risk-takers: how law enforcement practices at festivals can obstruct safer drug use 不情愿的冒险者:节日中的执法行为如何阻碍更安全的药物使用
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-09-20 DOI: 10.1016/j.drugpo.2025.105013
Dara Ruane

Background

Prohibition-based drug policies such as recent UK draft legislation on recreational drug possession assume expanding police powers will deter use and thereby reduce harm. In fact research suggests punitive policing harms PWUD (people who use drugs) in recreational contexts by incentivising behaviours with lower legal but higher health risk. Although some vectors of this harm have been well researched (notably dog-assisted searches at festival gates), others are less understood. This article aims to help elucidate them by examining how enforcement strategies impacted participants’ ability to enact ‘responsible drug use’ at events.

Methods

An ethnographic study of volunteer drug crisis care ('psy-care') projects in three contrasting policy regimes comprised 52 days of participant observation, 23 care practitioner interviews, and a qualitative survey of 54 festivalgoers. Thematic analysis was conducted in NVivo within a grounded theory framework.

Results

Although harm reduction-based practices were preferred by holders of the ‘responsible drug use’ value system and enacted whenever policy allowed, heavily policed settings disincentivised them or rendered them impossible while favouring medically riskier behaviours with lower legal risk. Confiscation at gates negated the risk mitigation effects of pre-measured, tested 'stashes'. Information-rich transactions with accountable dealers became unfeasible, while hasty, anonymous transactions appeared safer. Drug checking services (DCS) were rare, while informal sample checks involved legal jeopardy. Vigilance for police undermined efforts to cultivate a 'set and setting' conducive to unproblematic drug experiences, while both uniformed and undercover policing obstructed access to formal and informal crisis support.

Conclusions

This article shows that tough policing incentivises risk-taking even among those for whom 'responsible drug use' and harm reduction are strongly held values, illustrating the impact of policing-related perverse incentives on PWUD in recreational settings more generally.
以禁止为基础的毒品政策,如最近英国关于娱乐性毒品持有的立法草案,认为扩大警察权力将阻止使用,从而减少危害。事实上,研究表明,惩罚性警务会刺激合法风险较低但健康风险较高的行为,从而对娱乐环境中的吸毒者造成伤害。虽然这种危害的一些载体已经得到了很好的研究(特别是狗在节日门口的辅助搜索),但其他的还不太清楚。本文旨在通过研究执法策略如何影响参与者在活动中制定“负责任的药物使用”的能力来帮助阐明这些问题。方法对三种不同政策体制下的自愿药物危机护理(“心理护理”)项目进行了一项民族志研究,包括52天的参与者观察、23名护理从业者访谈和对54名节日参与者的定性调查。专题分析是在扎根理论框架内在NVivo进行的。结果:尽管“负责任的药物使用”价值体系的持有者更喜欢以减少伤害为基础的做法,并在政策允许的情况下实施,但严格的监管环境不利于他们或使他们不可能,而有利于法律风险较低的医学风险行为。在大门处的没收抵消了预先测量和测试的“藏匿物”的风险缓解效果。与负责任的交易商进行信息丰富的交易变得不可行,而仓促的匿名交易似乎更安全。毒品检查服务(DCS)很少,而非正式的抽样检查涉及法律危险。警察的警惕性破坏了培养一个有利于无问题吸毒体验的“环境和环境”的努力,而穿制服和便衣的警察阻碍了获得正式和非正式的危机支持。这篇文章表明,即使在那些“负责任的吸毒”和减少伤害是强烈价值观的人中,严厉的警务也会激励冒险行为,这说明了与警务相关的不当激励对娱乐环境中PWUD的影响更普遍。
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引用次数: 0
期刊
International Journal of Drug Policy
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