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A comprehensive analysis of jurisdiction-specific laws related to scheduling or required prescription drug monitoring of gabapentin in the United States, 2016–2024 2016-2024年美国与加巴喷丁调度或所需处方药监测相关的司法管辖区特定法律的综合分析
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-12-02 DOI: 10.1016/j.drugpo.2025.105064
Katherine Gora Combs , Rachel Vickers-Smith , Collin Stewart , Daniel Wacker , Juan M. Hincapie-Castillo
Gabapentin prescription use has increased across the United States since the late 2000s. Concerns of potential misuse and growing overdose involvement have led to the passage of jurisdiction-specific policies targeting gabapentin prescribing; however, the current legal landscape of these policies is not well documented or understood. We conducted a comprehensive, longitudinal analysis of policies related to scheduling or required prescription drug monitoring of gabapentin across 51 jurisdictions in the United States from January 2016 through December 2024. Across the study period, 25 jurisdictions (49 %) enacted policies related to gabapentin scheduling or required prescription reporting. Eight (16 %) jurisdictions classified gabapentin as a schedule V controlled substance and mandated reporting of gabapentin prescriptions in the jurisdiction’s prescription drug monitoring program (PDMP) and 17 (33 %) jurisdictions required the reporting of gabapentin prescriptions to the jurisdiction’s PDMP but did not classify gabapentin as a schedule V controlled substance. Both scheduling and mandated reporting policies were largely concentrated between 2016 and 2019. Though policy changes were observed across the entirety of the continental United States, the majority of jurisdictions with policies were concentrated in the Appalachian and Eastern Midwest regions. Our results provide a strong basis for future research on the impact of gabapentin scheduling and prescription drug monitoring policies on prescribing, dispensing, health care utilization, and overdose involvement. Future discussions at the state and federal level can also be informed by this analysis of the current legal landscape of gabapentin prescribing policies in the United States.
自2000年代末以来,加巴喷丁在美国的处方使用量有所增加。对潜在滥用和日益增长的过量参与的担忧导致针对加巴喷丁处方的司法管辖区特定政策的通过;然而,目前这些政策的法律格局并没有很好地记录或理解。从2016年1月到2024年12月,我们对美国51个司法管辖区的加巴喷丁的调度或所需处方药监测相关政策进行了全面的纵向分析。在整个研究期间,25个司法管辖区(49%)制定了与加巴喷丁调度或要求处方报告相关的政策。8个(16%)司法管辖区将加巴喷丁列为附表V受控物质,并要求在司法管辖区的处方药监测计划(PDMP)中报告加巴喷丁处方,17个(33%)司法管辖区要求向司法管辖区的PDMP报告加巴喷丁处方,但没有将加巴喷丁列为附表V受控物质。日程安排和强制性报告政策都主要集中在2016年至2019年之间。虽然整个美国大陆都观察到政策变化,但大多数有政策的司法管辖区集中在阿巴拉契亚和中西部东部地区。我们的研究结果为进一步研究加巴喷丁调度和处方药监测政策对处方、配药、医疗保健利用和过量用药的影响提供了强有力的基础。对美国目前加巴喷丁处方政策的法律环境的分析也可以为未来在州和联邦一级的讨论提供信息。
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引用次数: 0
Population size estimation of people who inject drugs using capture-recapture analysis of multiple respondent-driven sampling rounds: Implications for HIV/HCV burden and harm reduction service planning in Thessaloniki, Greece 在希腊塞萨洛尼基,使用多轮应答者驱动抽样的捕获-再捕获分析来估计注射吸毒者的人口规模:对艾滋病毒/丙型肝炎病毒负担和减少危害服务规划的影响
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-28 DOI: 10.1016/j.drugpo.2025.105078
Sotirios Roussos , Effrosyni Tsirogianni , Ioannis Goulis , Georgios Kalamitsis , Angelos Hatzakis , Vana Sypsa

Background

Accurate population size estimation of people who inject drugs (PWID) is essential for evidence-based drug policy and service planning, yet it remains challenging. An emerging HIV outbreak in Thessaloniki, Greece's second-largest city, highlighted the urgent need for evidence-based population size estimates.

Methods

We applied capture-recapture analysis to five respondent-driven sampling (RDS) rounds conducted during 2019–2021 to estimate PWID population size in Thessaloniki for the 2019–2021 period. These RDS rounds were part of a community-based program aimed at increasing HIV/HCV testing and linkage to care among PWID. We treated each RDS round as a capture source and used log-linear models to estimate PWID population size (past 12 months and past 30 days), accounting for potential dependencies between rounds through interaction terms. We then estimated HIV/HCV disease burden and assessed prevention and harm reduction service coverage against international standards (HIV testing, OAT, NSP).

Results

Based on data from 1093 unique participants across five rounds (53.9% currently injecting, 20.3% currently in OAT), capture-recapture analysis estimated 1512 PWID (95% confidence interval (CI): 1345–1741) who had injected drugs in the past 12 months. The estimated prevalence of injecting drug use was 0.22% (95% CI: 0.20–0.25) among adults aged 18–64 years. We estimated 106 people living with HIV (95% uncertainty interval (UI): 83–130) and 945 HCV-antibody–positive individuals (95% UI: 815–1077) among PWID. Needle and syringe program coverage was 36 (95% CI: 31–40) syringes per PWID in 2021.

Conclusion

Based on this community-based population size estimate, the prevalence of injection was nearly double the official national Greek average. The annual distribution of syringes should increase by 5.6 times to reach the WHO target (≥200 syringes/PWID/year). These findings demonstrate how community-based programs with multiple RDS rounds can also yield population estimates essential for evidence-based drug policy interventions.
准确估计注射吸毒者(PWID)的人口规模对于循证药物政策和服务规划至关重要,但这仍然具有挑战性。希腊第二大城市塞萨洛尼基正在爆发艾滋病毒疫情,这凸显了对基于证据的人口规模估计的迫切需要。方法对2019-2021年期间进行的5轮受访者驱动抽样(RDS)进行捕获-再捕获分析,以估计2019-2021年期间塞萨洛尼基PWID的种群规模。这些RDS轮次是一个以社区为基础的项目的一部分,该项目旨在增加艾滋病毒/丙型肝炎病毒检测,并将艾滋病患者与护理联系起来。我们将每一轮RDS视为捕获源,并使用对数线性模型估计PWID种群规模(过去12个月和过去30天),通过相互作用项考虑轮之间的潜在依赖关系。然后,我们估计了HIV/HCV疾病负担,并根据国际标准(HIV检测、OAT、NSP)评估了预防和减少危害服务的覆盖范围。基于5轮1093名独特参与者的数据(53.9%目前在注射,20.3%目前在OAT),捕获-再捕获分析估计了1512名PWID(95%置信区间(CI): 1345-1741)在过去12个月内注射过药物。18-64岁成年人中注射吸毒的估计流行率为0.22% (95% CI: 0.20-0.25)。我们估计PWID中有106名HIV感染者(95%不确定区间(UI): 83-130)和945名hcv抗体阳性个体(95% UI: 815-1077)。2021年,每个PWID的针头和注射器规划覆盖率为36支(95% CI: 31-40)支。基于社区人口规模估计,注射流行率几乎是希腊官方全国平均水平的两倍。为达到世卫组织的目标(≥200支/PWID/年),注射器的年分发量应增加5.6倍。这些发现表明,以社区为基础的多轮RDS项目也可以产生对基于证据的药物政策干预至关重要的人口估计。
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引用次数: 0
Evaluating cannabis substitution for alcohol within the context of a canadian managed alcohol program 在加拿大管理酒精方案范围内评估大麻替代酒精
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-27 DOI: 10.1016/j.drugpo.2025.105083
Sybil Goulet-Stock , Catherine Hacksel , Beatriz Scandiuzzi , Rob Boyd , Bernie Pauly , Tim Stockwell

Introduction

Managed Alcohol Programs (MAPs) provide beverage alcohol alongside housing and social supports to mitigate alcohol-related harms among individuals experiencing severe alcohol use disorder (AUD) and unstable housing. MAPs have been shown to stabilize alcohol use, reduce alcohol-related harms, improve quality of life, and decrease emergency service utilization. However, concerns about the long-term health risks associated with high levels of alcohol use have driven interest in cannabis substitution as an additional harm reduction strategy. Given the lower harm profile of cannabis, its integration into MAPs offers a promising avenue for further reducing alcohol-related harms. This study evaluates a novel cannabis substitution program within a Canadian MAP, leveraging the unique context of cannabis legalization and harm reduction programming.

Methods

Beginning in January 2023, participants (N = 35) were offered the choice of a pre-rolled cannabis joint or their prescribed alcohol dose multiple times per day. Data were drawn from five waves of quantitative surveys (January 2023 to February 2024; n = 20), two years of program records (January 2022 to February 2024; N = 35), and qualitative interviews (n = 14). Hierarchical mixed-effects models were used to predict alcohol use by cannabis use and time. Qualitative data were analyzed using interpretive description methodology.

Results

The final model found evidence of a substitution effect: participants who used more cannabis on average also consumed less alcohol overall. Specifically, each additional 0.4-gram joint consumed (approximately 15.2 standard THC units or 76 mg THC) was associated with an estimated 2.43 fewer mean daily standard drinks. Within-person cannabis use was not a significant predictor, indicating that short-term fluctuations in cannabis use were not associated with concurrent changes in alcohol consumption. Alcohol use also declined over time. Qualitative findings provide insights into the dynamic factors shaping drinking and cannabis use patterns.

Conclusion

This study highlights the potential for cannabis substitution to meaningfully reduce alcohol-related harms. Implications for program development and future research evaluating changes in health, wellbeing, and harm outcomes are discussed.
酒精管理项目(MAPs)提供酒精饮料以及住房和社会支持,以减轻患有严重酒精使用障碍(AUD)和住房不稳定的个人的酒精相关危害。map已被证明可以稳定酒精使用,减少酒精相关危害,改善生活质量,并减少紧急服务的利用。然而,由于担心与大量饮酒有关的长期健康风险,人们对大麻替代品产生了兴趣,将其作为一项额外的减少危害战略。鉴于大麻的危害较低,将其纳入MAPs为进一步减少与酒精有关的危害提供了一条有希望的途径。本研究评估了一个新的大麻替代方案在加拿大MAP,利用大麻合法化和减少危害规划的独特背景。方法从2023年1月开始,参与者(N = 35)每天多次选择预卷大麻关节或规定的酒精剂量。数据来自五波定量调查(2023年1月至2024年2月,n = 20)、两年的项目记录(2022年1月至2024年2月,n = 35)和定性访谈(n = 14)。使用分层混合效应模型来预测大麻使用和时间的酒精使用情况。定性数据采用解释性描述方法进行分析。最终的模型发现了替代效应的证据:使用更多大麻的参与者总体上也消耗了更少的酒精。具体来说,每多摄入0.4克大麻(约15.2个标准四氢大麻酚单位或76毫克四氢大麻酚),平均每日标准饮酒量就会减少2.43。个人使用大麻不是一个重要的预测指标,这表明大麻使用的短期波动与酒精消费量的同时变化无关。酒精的使用也随着时间的推移而减少。定性研究结果提供了对形成饮酒和大麻使用模式的动态因素的见解。结论:本研究强调了大麻替代品在减少酒精相关危害方面的潜力。讨论了项目开发和未来研究评估健康,福祉和危害结果的变化的含义。
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引用次数: 0
Psychedelics in the age of reproducibility: Reflections on aura, set and setting and the medicalization of mystical-type experiences 再现时代的迷幻剂:对灵气、场景和背景的反思以及神秘类型体验的医学化
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-25 DOI: 10.1016/j.drugpo.2025.105074
Guy Simon , Nir Tadmor MD , Demian Halperin
Psychedelics induce transformative experiences leading to lasting changes in attitudes and behaviour, with outcomes depending on both pharmacological factors and the context of the experience (‘set and setting’), marking a paradigm shift in mental health treatment. As psychedelics transition from traditional contexts to clinical settings, tension emerges between authenticity and standardization. This article uses Walter Benjamin’s concept of “aura” (The Work of Art in the Age of Mechanical Reproduction) to examine what may be lost or gained when psychedelic experiences are removed from original contexts and reproduced in institutional settings. We explore how set and setting contribute to authenticity, analyse medicalization’s implications, examine the roles of ritual and commodification, and propose ways to integrate traditional context with clinical approaches to preserve psychedelics’ transformative potential.
致幻剂诱发变革性体验,导致态度和行为的持久变化,其结果取决于药理学因素和体验的背景(“设定和环境”),标志着精神卫生治疗的范式转变。随着致幻剂从传统环境过渡到临床环境,真实性和标准化之间出现了紧张关系。本文使用Walter Benjamin的“光环”(机械复制时代的艺术作品)的概念来考察当迷幻体验从原始环境中移除并在制度环境中复制时可能失去或获得的东西。我们探讨了场景和环境如何对真实性做出贡献,分析了医学化的影响,研究了仪式和商品化的作用,并提出了将传统背景与临床方法相结合的方法,以保持迷幻药的变革潜力。
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引用次数: 0
COVID-19 vaccination uptake and risk of severe COVID-19 disease among those in, and released from, prison care in Scotland: a national cohort and case-control study 苏格兰监狱中和从监狱中释放的人接种COVID-19疫苗和患严重COVID-19疾病的风险:一项国家队列和病例对照研究
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-25 DOI: 10.1016/j.drugpo.2025.105080
Maxim Wilkinson , Alan Yeung , Jennifer Bishop , Ciara Gribben , Bob Taylor , Claire Cameron , Diane Stockton , Norah Palmateer , Sharon Hutchinson

Objectives

Given the potential higher risk of COVID-19 infection and disease for those incarcerated, we examined uptake of, and factors associated with vaccination, and the risks of severe disease for those in, and released from, prison in Scotland.

Methods

During follow-up (01/03/2020 to 13/04/2022), vaccine uptake among ∼15,000 individuals in prison, and following release, was compared with general population matched controls. Conditional logistic regression was used to compare prison status of ∼72,000 individuals admitted or died due to COVID-19 during follow-up to matched controls.

Results

By the end of follow-up, similar vaccine uptake was observed among those in prison (dose 1: 73.4 %, dose 2: 64.2 % and dose 3: 43.4 %) compared to matched controls (72.9 %, 67.9 % and 48.7 %). Individuals released (with <14 days incarcerated) were less likely to receive a first dose (aOR: 0.57, CI: 0.52, 0.66) than those who remained in prison. Following first and second doses, those released during the subsequent 12 weeks were less likely to receive their subsequent dose compared to those continuously incarcerated (aORs: 0.48, CI: 0.43, 0.54; 0.35, CI: 0.31, 0.40, respectively). Compared to the wider community outside prison, those incarcerated and recently released were more likely to be admitted or die from COVID-19 (aORs: 3.08, CI: 2.58, 3.69; and 4.53, CI: 3.37, 6.09, respectively).

Conclusions

Our findings highlight the important role of prisons in facilitating rapid high coverage of vaccination, involving accelerated schedules where appropriate, to help mitigate the raised risk of severe disease outcomes among both those incarcerated and released into the community.
考虑到被监禁者感染COVID-19和患病的潜在风险较高,我们调查了苏格兰监狱中和释放者接种疫苗的情况、与疫苗接种相关的因素以及严重疾病的风险。方法在随访期间(2020年3月1日至2022年4月13日),将约15,000名在押人员和释放后的疫苗接种情况与普通人群匹配的对照组进行比较。使用条件逻辑回归比较了匹配对照随访期间因COVID-19入院或死亡的约72,000人的监狱状况。结果随访结束时,在监狱中观察到的疫苗接种率(剂量1:73.4%,剂量2:64.2%和剂量3:43.4%)与匹配对照组(72.9%,67.9%和48.7%)相似。被释放的个体(被监禁14天)比仍在监狱中的个体更不可能接受第一剂(aOR: 0.57, CI: 0.52, 0.66)。在第一次和第二次给药后,那些在随后的12周内被释放的人比那些连续被监禁的人接受后续剂量的可能性更小(aor: 0.48, CI: 0.43, 0.54; 0.35, CI: 0.31, 0.40)。与监狱外更广泛的社区相比,被监禁和最近释放的人更有可能入院或死于COVID-19 (aor: 3.08, CI: 2.58, 3.69;和4.53,CI: 3.37, 6.09)。结论:我们的研究结果强调了监狱在促进疫苗快速高覆盖率方面的重要作用,包括酌情加快疫苗接种时间表,以帮助减轻在押人员和释放到社区的人员患严重疾病的风险。
{"title":"COVID-19 vaccination uptake and risk of severe COVID-19 disease among those in, and released from, prison care in Scotland: a national cohort and case-control study","authors":"Maxim Wilkinson ,&nbsp;Alan Yeung ,&nbsp;Jennifer Bishop ,&nbsp;Ciara Gribben ,&nbsp;Bob Taylor ,&nbsp;Claire Cameron ,&nbsp;Diane Stockton ,&nbsp;Norah Palmateer ,&nbsp;Sharon Hutchinson","doi":"10.1016/j.drugpo.2025.105080","DOIUrl":"10.1016/j.drugpo.2025.105080","url":null,"abstract":"<div><h3>Objectives</h3><div>Given the potential higher risk of COVID-19 infection and disease for those incarcerated, we examined uptake of, and factors associated with vaccination, and the risks of severe disease for those in, and released from, prison in Scotland.</div></div><div><h3>Methods</h3><div>During follow-up (01/03/2020 to 13/04/2022), vaccine uptake among ∼15,000 individuals in prison, and following release, was compared with general population matched controls. Conditional logistic regression was used to compare prison status of ∼72,000 individuals admitted or died due to COVID-19 during follow-up to matched controls.</div></div><div><h3>Results</h3><div>By the end of follow-up, similar vaccine uptake was observed among those in prison (dose 1: 73.4 %, dose 2: 64.2 % and dose 3: 43.4 %) compared to matched controls (72.9 %, 67.9 % and 48.7 %). Individuals released (with &lt;14 days incarcerated) were less likely to receive a first dose (aOR: 0.57, CI: 0.52, 0.66) than those who remained in prison. Following first and second doses, those released during the subsequent 12 weeks were less likely to receive their subsequent dose compared to those continuously incarcerated (aORs: 0.48, CI: 0.43, 0.54; 0.35, CI: 0.31, 0.40, respectively). Compared to the wider community outside prison, those incarcerated and recently released were more likely to be admitted or die from COVID-19 (aORs: 3.08, CI: 2.58, 3.69; and 4.53, CI: 3.37, 6.09, respectively).</div></div><div><h3>Conclusions</h3><div>Our findings highlight the important role of prisons in facilitating rapid high coverage of vaccination, involving accelerated schedules where appropriate, to help mitigate the raised risk of severe disease outcomes among both those incarcerated and released into the community.</div></div>","PeriodicalId":48364,"journal":{"name":"International Journal of Drug Policy","volume":"147 ","pages":"Article 105080"},"PeriodicalIF":4.4,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A scoping review and concept analysis to inform Canada’s safe(r) opioid supply research agenda 为加拿大阿片类药物安全供应研究议程提供信息的范围审查和概念分析。
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-24 DOI: 10.1016/j.drugpo.2025.105070
Uyen Do , Sarah Larney , Matthew Bonn , Ingrid Matei , Camille Zolopa , Amy Bergeron , Mohammad Karamouzian , Elaine Hyshka , Thomas D. Brothers , Nikki Bozinoff , Dan Werb , Didier Jutras-Aswad , Stine Høj , Isabelle Boisvert , Igor Yakovenko , Julie Bruneau

Background

Providing pharmaceutical opioid medications as alternatives to the unregulated drug market, commonly referred to as safe supply or safer supply (hereafter “safe(r) supply”), has emerged as a harm reduction strategy in Canada, with wide variation in principles and implementation. We aimed to clarify the concept of safe(r) opioid supply across harm-reduction and clinical contexts.

Methods

We conducted a scoping review and concept analysis. We systematically searched six major electronic databases and the grey literature to identify articles published between 2010 and 2024. Informed by Walker and Avant’s concept analysis methodology, we extracted definitions and descriptions of programs and interventions, organizing key characteristics into thematic dimensions to develop a framework distinguishing various care approaches.

Results

Our review included 95 articles. Safe(r) supply operationalizes under two broad approaches: a medicalized/prescribed approach (‘safer supply’) and a non-medicalized/community-based approach (‘safe supply’). We outlined three illustrative cases that nest within these approaches: (1) Prescribed opioids with opioid agonist therapy (OAT) offered and/or co-prescribed, (2) Prescribed opioids without OAT, (3) Community-based distribution of unregulated drugs with known composition.

Conclusion

Safe(r) supply encompasses prescribed opioid alternatives interventions (safer supply) and non-medicalized (safe supply) approaches with shared antecedents but distinct attributes and consequences. This study highlights the need to better define and standardize the parameters of safer supply approaches, including population, dosing, and intended objectives, to enable a more precise assessment of their potential benefits and risks. This nuanced understanding is crucial for developing evidence-based strategies in response to Canada’s drug poisoning crisis.
背景:提供阿片类药物作为不受管制药品市场的替代品,通常被称为安全供应或更安全供应(以下简称“安全(r)供应”),已成为加拿大的一项减少危害战略,其原则和实施方法差异很大。我们的目的是澄清安全(r)阿片类药物供应在危害减少和临床背景下的概念。方法:我们进行了范围回顾和概念分析。我们系统地检索了六个主要的电子数据库和灰色文献,以确定2010年至2024年间发表的文章。根据Walker和Avant的概念分析方法,我们提取了项目和干预措施的定义和描述,将关键特征组织到主题维度中,以开发一个区分各种护理方法的框架。结果:我们纳入了95篇文章。安全(r)供应在两种广泛的方法下运作:医疗化/处方化方法(“更安全的供应”)和非医疗化/社区为基础的方法(“安全供应”)。我们概述了这些方法中的三个说明性案例:(1)处方阿片类药物与阿片类激动剂治疗(OAT)一起提供和/或共同开处方;(2)处方阿片类药物不含OAT;(3)基于社区的已知成分的未监管药物分布。结论:安全(r)供应包括处方阿片类药物替代干预措施(更安全的供应)和非医疗(安全供应)方法,具有共同的前提,但不同的属性和后果。这项研究强调需要更好地定义和标准化安全供应方法的参数,包括人口、剂量和预期目标,以便能够更准确地评估其潜在利益和风险。这种细致入微的理解对于制定以证据为基础的战略以应对加拿大的药物中毒危机至关重要。
{"title":"A scoping review and concept analysis to inform Canada’s safe(r) opioid supply research agenda","authors":"Uyen Do ,&nbsp;Sarah Larney ,&nbsp;Matthew Bonn ,&nbsp;Ingrid Matei ,&nbsp;Camille Zolopa ,&nbsp;Amy Bergeron ,&nbsp;Mohammad Karamouzian ,&nbsp;Elaine Hyshka ,&nbsp;Thomas D. Brothers ,&nbsp;Nikki Bozinoff ,&nbsp;Dan Werb ,&nbsp;Didier Jutras-Aswad ,&nbsp;Stine Høj ,&nbsp;Isabelle Boisvert ,&nbsp;Igor Yakovenko ,&nbsp;Julie Bruneau","doi":"10.1016/j.drugpo.2025.105070","DOIUrl":"10.1016/j.drugpo.2025.105070","url":null,"abstract":"<div><h3>Background</h3><div>Providing pharmaceutical opioid medications as alternatives to the unregulated drug market, commonly referred to as safe supply or safer supply (hereafter “safe(r) supply”), has emerged as a harm reduction strategy in Canada, with wide variation in principles and implementation. We aimed to clarify the concept of safe(r) opioid supply across harm-reduction and clinical contexts.</div></div><div><h3>Methods</h3><div>We conducted a scoping review and concept analysis. We systematically searched six major electronic databases and the grey literature to identify articles published between 2010 and 2024. Informed by Walker and Avant’s concept analysis methodology, we extracted definitions and descriptions of programs and interventions, organizing key characteristics into thematic dimensions to develop a framework distinguishing various care approaches.</div></div><div><h3>Results</h3><div>Our review included 95 articles. Safe(r) supply operationalizes under two broad approaches: a medicalized/prescribed approach (‘safer supply’) and a non-medicalized/community-based approach (‘safe supply’). We outlined three illustrative cases that nest within these approaches: (1) Prescribed opioids with opioid agonist therapy (OAT) offered and/or co-prescribed, (2) Prescribed opioids without OAT, (3) Community-based distribution of unregulated drugs with known composition.</div></div><div><h3>Conclusion</h3><div>Safe(r) supply encompasses prescribed opioid alternatives interventions (safer supply) and non-medicalized (safe supply) approaches with shared antecedents but distinct attributes and consequences. This study highlights the need to better define and standardize the parameters of safer supply approaches, including population, dosing, and intended objectives, to enable a more precise assessment of their potential benefits and risks. This nuanced understanding is crucial for developing evidence-based strategies in response to Canada’s drug poisoning crisis.</div></div>","PeriodicalId":48364,"journal":{"name":"International Journal of Drug Policy","volume":"147 ","pages":"Article 105070"},"PeriodicalIF":4.4,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145606914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing non-fatal overdose among people who inject drugs in India: prevalence and risk factor analysis, 2022-2024 印度注射毒品人群中非致命性过量的特征:患病率和风险因素分析,2022-2024
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-22 DOI: 10.1016/j.drugpo.2025.105073
Mihili P. Gunaratne , Talia A. Loeb , Allison M. McFall , Lakshmi Ganapathi , Jiban J. Baishya , Ashwini Kedar , Archit K. Sinha , Aylur K. Srikrishnan , Sunil S. Solomon , Gregory M. Lucas , Shruti H. Mehta

Background

Non-fatal overdose strongly predicts future fatal overdose, yet limited prior work describes the burden among people who inject drugs (PWID) in India. We estimated prevalence and identified correlates of non-fatal overdose among PWID from India.

Methods

We conducted respondent-driven sampling (RDS) surveys among PWID across 6 Indian cities (n∼750/site; Amritsar, Bilaspur, Churchandpur, Delhi, Kanpur, and Ludhiana) during 2022–2024. Prevalence of non-fatal overdose in the prior 6 months and non-mutually exclusive events following the overdose were estimated using RDS-weighted descriptive statistics. Correlates (i.e., sociodemographics, HIV and hepatitis C status, substance use in the prior 6 months, and psychosocial symptoms) were assessed using multilevel logistic regression.

Results

Prevalence of non-fatal overdose was 8.8% among 4495 PWID. Factors significantly associated with overdose included daily or seasonal employment (vs. monthly or weekly wages), hepatitis C antibody positive status, witnessing a fatal overdose, injecting 3 or more times per day (vs. 1–2 times per day), concurrent use of heroin and stimulants (vs. buprenorphine or other prescription opioids only), hazardous alcohol use, attending a medical facility for addiction or detoxification, and experiencing mild or depressive symptoms (vs. none). Following the overdose, 44.7% reported help from a friend or family member, 25.5% reported nothing happened, 12.9% went to a hospital, and 5.6% were referred to drug treatment or detoxification.

Conclusions

We observed a variable burden of non-fatal overdose associated with high injection frequency, combination drug use, alcohol use, attending medical detoxification, and depressive symptoms. Low levels of subsequent linkage to treatment services suggest opportunities to improve overdose prevention and management.
背景:非致命性药物过量强烈预测未来致命性药物过量,然而有限的先前工作描述了印度注射吸毒者(PWID)的负担。我们估计了印度PWID的患病率,并确定了非致命性用药过量的相关因素。方法我们在2022-2024年期间对印度6个城市的PWID进行了受访者驱动抽样(RDS)调查(n ~ 750/站点;阿姆利则、比拉斯普尔、丘尔昌普尔、德里、坎普尔和卢迪亚纳)。使用rds加权描述性统计估计前6个月内非致死性用药过量发生率和用药过量后非互斥事件发生率。相关因素(即社会人口统计学、艾滋病毒和丙型肝炎状况、前6个月的药物使用情况以及心理社会症状)采用多水平logistic回归进行评估。结果4495例PWID患者非致死性用药过量发生率为8.8%。与药物过量显著相关的因素包括每日或季节性就业(相对于每月或每周工资)、丙型肝炎抗体阳性、目睹致命的药物过量、每天注射3次或更多次(相对于每天1-2次)、同时使用海洛因和兴奋剂(相对于丁丙诺啡或其他处方阿片类药物)、危险饮酒、因成瘾或戒毒而前往医疗机构、经历轻度或抑郁症状(相对于无)。在吸毒过量后,44.7%的人表示得到了朋友或家人的帮助,25.5%的人表示什么也没发生,12.9%的人去了医院,5.6%的人接受了药物治疗或戒毒。结论:我们观察到非致死性药物过量的可变负担与高注射频率、联合用药、酒精使用、参加医学解毒和抑郁症状相关。随后与治疗服务的低水平联系表明有机会改进过量预防和管理。
{"title":"Characterizing non-fatal overdose among people who inject drugs in India: prevalence and risk factor analysis, 2022-2024","authors":"Mihili P. Gunaratne ,&nbsp;Talia A. Loeb ,&nbsp;Allison M. McFall ,&nbsp;Lakshmi Ganapathi ,&nbsp;Jiban J. Baishya ,&nbsp;Ashwini Kedar ,&nbsp;Archit K. Sinha ,&nbsp;Aylur K. Srikrishnan ,&nbsp;Sunil S. Solomon ,&nbsp;Gregory M. Lucas ,&nbsp;Shruti H. Mehta","doi":"10.1016/j.drugpo.2025.105073","DOIUrl":"10.1016/j.drugpo.2025.105073","url":null,"abstract":"<div><h3>Background</h3><div>Non-fatal overdose strongly predicts future fatal overdose, yet limited prior work describes the burden among people who inject drugs (PWID) in India. We estimated prevalence and identified correlates of non-fatal overdose among PWID from India.</div></div><div><h3>Methods</h3><div>We conducted respondent-driven sampling (RDS) surveys among PWID across 6 Indian cities (n∼750/site; Amritsar, Bilaspur, Churchandpur, Delhi, Kanpur, and Ludhiana) during 2022–2024. Prevalence of non-fatal overdose in the prior 6 months and non-mutually exclusive events following the overdose were estimated using RDS-weighted descriptive statistics. Correlates (i.e., sociodemographics, HIV and hepatitis C status, substance use in the prior 6 months, and psychosocial symptoms) were assessed using multilevel logistic regression.</div></div><div><h3>Results</h3><div>Prevalence of non-fatal overdose was 8.8% among 4495 PWID. Factors significantly associated with overdose included daily or seasonal employment (vs. monthly or weekly wages), hepatitis C antibody positive status, witnessing a fatal overdose, injecting 3 or more times per day (vs. 1–2 times per day), concurrent use of heroin and stimulants (vs. buprenorphine or other prescription opioids only), hazardous alcohol use, attending a medical facility for addiction or detoxification, and experiencing mild or depressive symptoms (vs. none). Following the overdose, 44.7% reported help from a friend or family member, 25.5% reported nothing happened, 12.9% went to a hospital, and 5.6% were referred to drug treatment or detoxification.</div></div><div><h3>Conclusions</h3><div>We observed a variable burden of non-fatal overdose associated with high injection frequency, combination drug use, alcohol use, attending medical detoxification, and depressive symptoms. Low levels of subsequent linkage to treatment services suggest opportunities to improve overdose prevention and management.</div></div>","PeriodicalId":48364,"journal":{"name":"International Journal of Drug Policy","volume":"147 ","pages":"Article 105073"},"PeriodicalIF":4.4,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A response to Weatherburn et al. (2025) ‘Risky alcohol use and violence against women: cause or consequence?’ 对Weatherburn等人(2025年)的《危险饮酒和对妇女的暴力行为:原因还是后果?》”
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-21 DOI: 10.1016/j.drugpo.2025.105077
Megan Cook, Amy Pennay, Sarah Callinan
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引用次数: 0
Quantitative controls on the number and/or location of alcohol retail outlets: an overview of approaches in the USA and Canada 酒精零售网点数量和/或位置的定量控制:美国和加拿大方法概述。
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-20 DOI: 10.1016/j.drugpo.2025.105075
Robyn Burton , Pamela Trangenstein , Megan Cook , Niamh Fitzgerald , James Nicholls

Background

Regulatory approaches to alcohol availability vary widely, yet policies that control the number or location of alcohol retail outlets remain under-documented. This study aimed to identify and describe these approaches across jurisdictions in the USA and Canada.

Methods

A two-stage document analysis was conducted for all 50 states, 10 Canadian provinces, and three Canadian territories (jurisdictions). Relevant legislative documents were identified and reviewed, with data extracted on policies establishing quantitative thresholds on either total outlet numbers (including outright prohibition), outlets numbers per population, distances between alcohol retail outlets, or distances between alcohol retail outlets and sensitive locations such as schools. Data collection took place between March and May 2024.

Results

Among 63 jurisdictions, 56 (88.9 %) used at least one approach to limiting the number and/or location of alcohol retail outlets, with 39 (61.9 %) using two or more. The most common approach (63.5 % of jurisdictions) was limiting minimum distances between outlets and specific locations, such as schools or places-of-worship. Population-based limits on outlet density were used by 44.4 % of jurisdictions, but thresholds varied substantially, (e.g. from 1.36 to 200 outlets per 100,000 population for on-sales, and 5.00 to 200 per 100,000 population for off-sales). Nearly half of all jurisdictions (47.6 %) had at least one dry county or area, while a smaller proportion (17.5 %) set minimum distances between outlets to prevent clustering. Fixed caps on the absolute number of outlets, regardless of population size, were least common (12.7 %).

Conclusion

Quantitative controls on the number and/or location of alcohol retail outlets are widely used across the USA and Canada but vary significantly in structure and stringency. While some jurisdictions impose multiple controls, others apply none. Understanding these policy approaches provides insight into regulatory frameworks but does not indicate enforcement levels or public health impact. Further research could examine how these measures are implemented and whether different models influence alcohol availability.
背景:对酒精供应的监管方法差异很大,但控制酒精零售网点数量或地点的政策仍未得到充分记录。本研究旨在识别和描述美国和加拿大各司法管辖区的这些方法。方法:对所有50个州、加拿大10个省和加拿大3个地区(管辖区)进行了两阶段的文献分析。对相关立法文件进行了鉴定和审查,并提取了有关政策方面的数据,这些政策建立了定量阈值,包括销售点总数(包括完全禁止)、人均销售点数量、酒类零售网点之间的距离或酒类零售网点与学校等敏感地点之间的距离。数据收集于2024年3月至5月进行。结果:在63个司法管辖区中,56个(88.9%)使用了至少一种方法来限制酒类零售店的数量和/或位置,39个(61.9%)使用了两种或两种以上。最常见的做法(63.5%的司法管辖区)是限制销售点与特定地点(如学校或礼拜场所)之间的最小距离。44.4%的司法管辖区采用了基于人口的门店密度限制,但阈值差异很大(例如,每10万人口中有1.36至200家门店进行销售,每10万人口中有5.00至200家门店进行销售)。近一半的司法管辖区(47.6%)至少有一个干旱县或地区,而较小比例(17.5%)设置了网点之间的最小距离以防止聚集。无论人口规模大小,对门店绝对数量设定上限的做法最不常见(12.7%)。结论:酒精零售店数量和/或位置的定量控制在美国和加拿大广泛使用,但在结构和严格程度上差异很大。虽然一些司法管辖区实施多种控制措施,但其他司法管辖区则没有。了解这些政策方法有助于深入了解监管框架,但不能表明执法水平或公共卫生影响。进一步的研究可以检验这些措施是如何实施的,以及不同的模式是否会影响酒精的供应。
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引用次数: 0
Young adults’ sourcing and supply of opioids in a changing drug market 年轻人在不断变化的毒品市场中寻找和供应阿片类药物
IF 4.4 2区 医学 Q1 SUBSTANCE ABUSE Pub Date : 2025-11-16 DOI: 10.1016/j.drugpo.2025.105072
Maj Nygaard-Christensen , Thomas Friis Søgaard , Esben Houborg , Birgitte Thylstrup

Background

In Denmark, rising concern over young people’s non-prescribed use of opioids such as tramadol and oxycodone has fueled media narratives invoking predatory suppliers and vulnerable youth, with a key emphasis on kiosks and social media as venues that make opioids immediately accessible to young people. To inform effective policy responses, more nuanced, empirically grounded understandings of youth opioid sourcing are needed.

Methods

The article draws on qualitative data from a Danish study on non-prescribed use of tramadol and oxycodone among treatment-enrolled young adults and stakeholders in prevention and treatment. We analyze interviews with 30 young adults (20 male, 10 female, aged 18–32, median age 24.2) enrolled in municipal opioid agonist treatment (OAT) across eight municipalities. Interviews explored pathways into use, treatment experiences, and sourcing practices. This analysis centers on data related to acquisition, with attention to the role of social networks in facilitating access to non-prescribed opioids.

Results

Participants were predominantly young adults with prior experience of illegal drug use, often involving early initiation and poly-drug experimentation. The majority were introduced to opioids by friends or acquaintances and continued sourcing opioids through social networks, in addition to kiosks, online platforms, and prescriptions. Several participants had also engaged in small-scale sales or smuggling, often through existing relationships or to support their own use. Fluid boundaries between use and supply were common.

Conclusion

The study shows that young adults access opioids from a variety of sources that often start with sourcing opioids through social networks, especially during the early stages of use. These insights call for nuanced prevention strategies that move beyond individual consumer models and address the complex social dynamics of non-prescribed opioid access and use.
在丹麦,人们对年轻人非处方使用曲马多和羟考酮等阿片类药物的担忧日益加剧,这引发了媒体对掠夺性供应商和弱势青年的报道,重点强调信息亭和社交媒体是年轻人立即获得阿片类药物的场所。为了为有效的政策反应提供信息,需要对青年阿片类药物来源进行更细致入微的、基于经验的理解。方法:本文借鉴了丹麦一项关于曲马多和羟考酮在接受治疗的年轻人和预防和治疗利益相关者中非处方使用的定性研究数据。我们分析了来自8个城市的30名年轻人(20名男性,10名女性,年龄18-32岁,中位年龄24.2岁)参加了阿片类药物激动剂治疗(OAT)。访谈探讨了使用途径、治疗经验和采购实践。该分析以获取相关数据为中心,关注社交网络在促进获取非处方阿片类药物方面的作用。结果参与者主要是有非法药物使用经验的年轻人,通常涉及早期开始和多种药物实验。大多数人是由朋友或熟人介绍给阿片类药物的,除了信息亭、在线平台和处方外,他们还继续通过社交网络采购阿片类药物。一些参与者还从事小规模的销售或走私,往往是通过现有的关系或为了支持自己的使用。使用和供应之间不固定的界限很常见。研究表明,年轻人获得阿片类药物的来源多种多样,通常是从社交网络开始的,尤其是在使用的早期阶段。这些见解要求采取细致入微的预防策略,超越个人消费者模式,解决非处方阿片类药物获取和使用的复杂社会动态。
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引用次数: 0
期刊
International Journal of Drug Policy
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