Pub Date : 2025-04-11DOI: 10.1016/j.cpr.2025.102585
Matthew Bourke , Hiu Fei Wendy Wang , Sarah A. McNaughton , George Thomas , Joseph Firth , Mike Trott , John Cairney
Engagement in healthy and unhealthy lifestyle behaviours are related to a range of mental health outcomes. Most existing research has focussed on individual lifestyle behaviours, so it is not clear the extent to which clusters of healthy lifestyle behaviours relate to mental health outcomes. Therefore, this study aimed to systematically review and quantitatively synthesise research which have examined the association between clusters of lifestyle behaviours with symptoms of depression, anxiety, and psychological distress. A systematic search of five electronic databases were conducted to identify studies which used person-centred approaches (e.g., cluster analysis, latent class analysis) to identify subgroups of participants based on at least two unique lifestyle behaviours (i.e., physical activity/sedentary behaviours, diet, sleep, alcohol/tobacco/drug use) and examined differences in symptoms of depression, anxiety, or psychological distress between clusters. A correlated and hierarchical random effects meta-analysis was used to synthesise the results. A total of 81 studies reporting on nearly one-million individual participants were included in the review. Results demonstrated that participants who engaged in the healthiest clusters of lifestyle behaviours reported significantly fewer symptoms of depression (SMD = −0.41), anxiety (SMD = −0.43) and psychological distress (SMD = −0.34) compared to participants engaging in less healthy combinations of lifestyle behaviours, and a dose response relationship was observed across outcomes. These results demonstrate that there is a moderate-to-strong relationship between engaging in clusters of healthy lifestyle behaviours and mental health outcomes and demonstrate the importance of considering healthy lifestyle as a whole instead of as individual parts.
{"title":"Clusters of healthy lifestyle behaviours are associated with symptoms of depression, anxiety, and psychological distress: A systematic review and meta-analysis of observational studies","authors":"Matthew Bourke , Hiu Fei Wendy Wang , Sarah A. McNaughton , George Thomas , Joseph Firth , Mike Trott , John Cairney","doi":"10.1016/j.cpr.2025.102585","DOIUrl":"10.1016/j.cpr.2025.102585","url":null,"abstract":"<div><div>Engagement in healthy and unhealthy lifestyle behaviours are related to a range of mental health outcomes. Most existing research has focussed on individual lifestyle behaviours, so it is not clear the extent to which clusters of healthy lifestyle behaviours relate to mental health outcomes. Therefore, this study aimed to systematically review and quantitatively synthesise research which have examined the association between clusters of lifestyle behaviours with symptoms of depression, anxiety, and psychological distress. A systematic search of five electronic databases were conducted to identify studies which used person-centred approaches (e.g., cluster analysis, latent class analysis) to identify subgroups of participants based on at least two unique lifestyle behaviours (i.e., physical activity/sedentary behaviours, diet, sleep, alcohol/tobacco/drug use) and examined differences in symptoms of depression, anxiety, or psychological distress between clusters. A correlated and hierarchical random effects meta-analysis was used to synthesise the results. A total of 81 studies reporting on nearly one-million individual participants were included in the review. Results demonstrated that participants who engaged in the healthiest clusters of lifestyle behaviours reported significantly fewer symptoms of depression (SMD = −0.41), anxiety (SMD = −0.43) and psychological distress (SMD = −0.34) compared to participants engaging in less healthy combinations of lifestyle behaviours, and a dose response relationship was observed across outcomes. These results demonstrate that there is a moderate-to-strong relationship between engaging in clusters of healthy lifestyle behaviours and mental health outcomes and demonstrate the importance of considering healthy lifestyle as a whole instead of as individual parts.</div></div>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"118 ","pages":"Article 102585"},"PeriodicalIF":13.7,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-06DOI: 10.1016/j.cpr.2025.102584
Siobhan M. O'Dean , Elizabeth Summerell , Eddie Harmon-Jones , J David Creswell , Thomas F. Denson
Dispositional mindfulness and mindfulness-based interventions have been linked to emotion regulation and may reduce anger and aggression. The present set of four meta-analyses examined and quantified correlational relationships between trait mindfulness, trait anger, and trait aggression, as well as the effects of experimental mindfulness-based interventions on anger and aggression. These meta-analyses contained data from 118 correlational (dispositional mindfulness) and experimental (mindfulness-based intervention) studies. For the subset of self-report correlational studies (kanger = 243, kaggression = 286), we found small-to-medium inverse relationships between dispositional mindfulness and both anger (r = −0.23, p < .001) and aggression (r = −0.19, p < .001). For experimental studies (kanger = 95, kaggression = 38), we found medium effects. Specifically, mindfulness-based interventions produced lower anger (d = −0.48, p < .001) and aggression (d = −0.61, p < .001) relative to the control groups. In sum, results suggest that mindfulness can curb angry and aggressive responses. Effect sizes for the interventions were largest in Asia. Studies with passive versus active control groups showed larger effect sizes. Effect sizes were largely equivalent for all populations studied (e.g., clinical, forensic, healthy adults, medical, students). Our meta-analytic findings suggest that mindfulness training may aid the effective regulation of anger and aggression for diverse populations. They also highlight the need for more rigorous control groups in future research.
{"title":"The associations and effects of mindfulness on anger and aggression: A meta-analytic review","authors":"Siobhan M. O'Dean , Elizabeth Summerell , Eddie Harmon-Jones , J David Creswell , Thomas F. Denson","doi":"10.1016/j.cpr.2025.102584","DOIUrl":"10.1016/j.cpr.2025.102584","url":null,"abstract":"<div><div>Dispositional mindfulness and mindfulness-based interventions have been linked to emotion regulation and may reduce anger and aggression. The present set of four meta-analyses examined and quantified correlational relationships between trait mindfulness, trait anger, and trait aggression, as well as the effects of experimental mindfulness-based interventions on anger and aggression. These meta-analyses contained data from 118 correlational (dispositional mindfulness) and experimental (mindfulness-based intervention) studies. For the subset of self-report correlational studies (<em>k</em><sub>anger</sub> = 243, <em>k</em><sub>aggression</sub> = 286), we found small-to-medium inverse relationships between dispositional mindfulness and both anger (<em>r</em> = −0.23, <em>p</em> < .001) and aggression (<em>r</em> = −0.19, <em>p</em> < .001). For experimental studies (<em>k</em><sub>anger</sub> = 95, <em>k</em><sub>aggression</sub> = 38), we found medium effects. Specifically, mindfulness-based interventions produced lower anger (<em>d</em> = −0.48, <em>p</em> < .001) and aggression (<em>d</em> = −0.61, <em>p</em> < .001) relative to the control groups. In sum, results suggest that mindfulness can curb angry and aggressive responses. Effect sizes for the interventions were largest in Asia. Studies with passive versus active control groups showed larger effect sizes. Effect sizes were largely equivalent for all populations studied (e.g., clinical, forensic, healthy adults, medical, students). Our meta-analytic findings suggest that mindfulness training may aid the effective regulation of anger and aggression for diverse populations. They also highlight the need for more rigorous control groups in future research.</div></div>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"118 ","pages":"Article 102584"},"PeriodicalIF":13.7,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.cpr.2025.102583
Victoria Pile, Stephen A. McIntyre, Jessica Richardson
{"title":"Response to Dr Rubinstein's commentary on systematic review of measures of mental imagery in emotional disorders","authors":"Victoria Pile, Stephen A. McIntyre, Jessica Richardson","doi":"10.1016/j.cpr.2025.102583","DOIUrl":"https://doi.org/10.1016/j.cpr.2025.102583","url":null,"abstract":"","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"5 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-02DOI: 10.1016/j.cpr.2025.102582
Dori Rubinstein
McIntyre et al. (2024) conducted a systematic review of mental imagery measures in emotional disorders using the COSMIN framework. While their work is a valuable contribution, several methodological issues raise concerns about the validity of their conclusions. This commentary discusses three key issues: (1) potential misinterpretation of scale construct definitions, (2) inconsistencies in study selection, and (3) limited consideration of the adaptive role of mental imagery. The Fantastic Reality Ability Measurement (FRAME) scale serves as an illustrative example. Addressing these limitations is crucial to ensuring that future systematic reviews accurately reflect the scope, function, and psychometric properties of mental imagery measures.
{"title":"Refining the evaluation of mental imagery measures: A commentary on.","authors":"Dori Rubinstein","doi":"10.1016/j.cpr.2025.102582","DOIUrl":"https://doi.org/10.1016/j.cpr.2025.102582","url":null,"abstract":"<p><p>McIntyre et al. (2024) conducted a systematic review of mental imagery measures in emotional disorders using the COSMIN framework. While their work is a valuable contribution, several methodological issues raise concerns about the validity of their conclusions. This commentary discusses three key issues: (1) potential misinterpretation of scale construct definitions, (2) inconsistencies in study selection, and (3) limited consideration of the adaptive role of mental imagery. The Fantastic Reality Ability Measurement (FRAME) scale serves as an illustrative example. Addressing these limitations is crucial to ensuring that future systematic reviews accurately reflect the scope, function, and psychometric properties of mental imagery measures.</p>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":" ","pages":"102582"},"PeriodicalIF":13.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.cpr.2025.102580
Alex H.K. Wong
Extinction learning refers to a reduction in fear to a conditioned stimulus (CS) that previously signaled a threat, but now occurs without the expected threat. This mechanism is core to exposure-based treatments for anxiety-related disorders. Enhancing the generalization of extinction learning is crucial for improving treatment outcomes, as it helps reduce fear across a range of generalization stimuli (GSs) resembling the original fear-evoking CS. This narrative review identifies and covers three generalization of extinction learning models: 1) generalization of CS extinction learning, examining how extinction learning to the CS generalizes to novel GSs, 2) generalization of GS extinction learning, assessing how extinction learning to a GS generalizes to other novel GSs or the original CS, and 3) generalization of multiple stimuli extinction learning, where extinction learning involves multiple GSs (and sometimes the CS) and its effect on other novel stimuli. While extinction learning to the CS effectively generalizes to other stimuli, extinction learning to a GS or multiple GSs showed limited generalization to other novel GSs or the original CS. Since real-life exposure-based treatment rarely reproduces the CS, extinction learning involving only the GS(s) may better reflect clinical practice; poor generalization of GS(s) extinction learning may constitute another pathway of return of fear. This review also highlights various factors that influence generalization of extinction learning and call for future research to develop strategies for improving these processes, which can help inform exposure-based treatments.
{"title":"Spreading the reduction of fear: A narrative review of generalization of extinction learning in human fear conditioning","authors":"Alex H.K. Wong","doi":"10.1016/j.cpr.2025.102580","DOIUrl":"10.1016/j.cpr.2025.102580","url":null,"abstract":"<div><div>Extinction learning refers to a reduction in fear to a conditioned stimulus (CS) that previously signaled a threat, but now occurs without the expected threat. This mechanism is core to exposure-based treatments for anxiety-related disorders. Enhancing the generalization of extinction learning is crucial for improving treatment outcomes, as it helps reduce fear across a range of generalization stimuli (GSs) resembling the original fear-evoking CS. This narrative review identifies and covers three generalization of extinction learning models: 1) generalization of CS extinction learning, examining how extinction learning to the CS generalizes to novel GSs, 2) generalization of GS extinction learning, assessing how extinction learning to a GS generalizes to other novel GSs or the original CS, and 3) generalization of multiple stimuli extinction learning, where extinction learning involves multiple GSs (and sometimes the CS) and its effect on other novel stimuli. While extinction learning to the CS effectively generalizes to other stimuli, extinction learning to a GS or multiple GSs showed limited generalization to other novel GSs or the original CS. Since real-life exposure-based treatment rarely reproduces the CS, extinction learning involving only the GS(s) may better reflect clinical practice; poor generalization of GS(s) extinction learning may constitute another pathway of return of fear. This review also highlights various factors that influence generalization of extinction learning and call for future research to develop strategies for improving these processes, which can help inform exposure-based treatments.</div></div>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"118 ","pages":"Article 102580"},"PeriodicalIF":13.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-30DOI: 10.1016/j.cpr.2025.102579
Jorge A. Cao-Noya, Cossette Canovas, Lorraine T. Benuto
The efficacy of posttraumatic stress disorder (PTSD) treatments might be hampered by individual differences. In order to maximize treatment efficacy in existing and newly developed interventions, controlling for individual variables is essential in treatment research. Given the marked physiological correlates of PTSD, biomarkers represent a promising solution. Throughout the PTSD literature, biomarkers have been used to assess treatment effects and predict treatment outcomes. However, the wide variety of biomarkers studied, along with several conflicting results, hinder researchers' abilities to comprehensively interpret the results reported. This systematic review of the literature aimed to identify and classify all biomarkers used to assess the efficacy of PTSD interventions and identify pre-treatment biomarkers able to predict treatment outcomes. Following PRISMA guidelines, we identified 70 studies that assessed biomarkers sensitivity to treatment effects and 25 that used biomarkers to predict treatment outcomes. Well-established treatments and newly developed protocols were included. The results were classified and interpreted by biomarker type. Indicators of neuroanatomical structures and functions were the most commonly studied biomarkers, followed by markers of cardiac activation and glucocorticoid analytes. Cardiac activation markers, and concretely heart rate reactivity to trauma cues, showed the most consistent findings, serving as a valuable method to assess treatment effects across different populations and treatment modalities. Other biomarkers showed promising trends both as predictors of treatment outcomes and measures of treatment efficacy, although essential methodological differences significantly impacted the comparison across studies.
{"title":"The use of biomarkers as measures of PTSD treatment efficacy and predictors of treatment outcomes: A systematic review","authors":"Jorge A. Cao-Noya, Cossette Canovas, Lorraine T. Benuto","doi":"10.1016/j.cpr.2025.102579","DOIUrl":"10.1016/j.cpr.2025.102579","url":null,"abstract":"<div><div>The efficacy of posttraumatic stress disorder (PTSD) treatments might be hampered by individual differences. In order to maximize treatment efficacy in existing and newly developed interventions, controlling for individual variables is essential in treatment research. Given the marked physiological correlates of PTSD, biomarkers represent a promising solution. Throughout the PTSD literature, biomarkers have been used to assess treatment effects and predict treatment outcomes. However, the wide variety of biomarkers studied, along with several conflicting results, hinder researchers' abilities to comprehensively interpret the results reported. This systematic review of the literature aimed to identify and classify all biomarkers used to assess the efficacy of PTSD interventions and identify pre-treatment biomarkers able to predict treatment outcomes. Following PRISMA guidelines, we identified 70 studies that assessed biomarkers sensitivity to treatment effects and 25 that used biomarkers to predict treatment outcomes. Well-established treatments and newly developed protocols were included. The results were classified and interpreted by biomarker type. Indicators of neuroanatomical structures and functions were the most commonly studied biomarkers, followed by markers of cardiac activation and glucocorticoid analytes. Cardiac activation markers, and concretely heart rate reactivity to trauma cues, showed the most consistent findings, serving as a valuable method to assess treatment effects across different populations and treatment modalities. Other biomarkers showed promising trends both as predictors of treatment outcomes and measures of treatment efficacy, although essential methodological differences significantly impacted the comparison across studies.</div></div>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"118 ","pages":"Article 102579"},"PeriodicalIF":13.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-29DOI: 10.1016/j.cpr.2025.102581
Nora de Bode , Emese Kroon , Sharon R. Sznitman , Janna Cousijn
The use of medicinal cannabis to improve mental health is increasing globally, both in clinical settings and through self-medication. This involves a variety of products containing ∆9-tetrahydrocannabinol (THC), cannabidiol (CBD), THC + CBD combinations, or derivatives. This review provides an up-to-date overview of the positive and negative effects of medicinal cannabis on mental health diagnoses and related symptoms of the Diagnostic and Statistical Manual of Mental Disorders 5th Edition. Searches in PubMed, PsycInfo, Embase, and the Cochrane Library (October 2023 and July 2024) identified 18,341 studies, of which 49 controlled studies from 15 different countries were included. All studies focused on treatment-seeking participants using medicinal cannabis for (symptoms of) their mental health diagnosis. Included diagnoses were anxiety disorders, tic disorders, autism spectrum disorder, attention-deficit hyperactivity disorder, obsessive-compulsive disorders, anorexia nervosa, schizophrenia, psychosis, substance use disorders, insomnia, and bipolar disorders. Varying product compositions showed different effects. Most consistently, high doses of CBD were followed by some acute relief in anxiety, while CBD + THC combinations alleviated withdrawal in cannabis use disorder and improved sleep. In clinical trials, THC was associated most with dose-dependent adverse events and, in some cases, deterioration of primary study outcomes, e.g., in psychosis. In naturalistic studies, participants who used THC reported symptom improvement following usage. Risks of bias across studies were prevalent, and no study found long-lasting medicinal effects or improvement. Overall, medicinal cannabis may provide short-term relief for certain symptoms but is not a cure or without mental health risks.
{"title":"The differential effects of medicinal cannabis on mental health: A systematic review","authors":"Nora de Bode , Emese Kroon , Sharon R. Sznitman , Janna Cousijn","doi":"10.1016/j.cpr.2025.102581","DOIUrl":"10.1016/j.cpr.2025.102581","url":null,"abstract":"<div><div>The use of medicinal cannabis to improve mental health is increasing globally, both in clinical settings and through self-medication. This involves a variety of products containing ∆9-tetrahydrocannabinol (THC), cannabidiol (CBD), THC + CBD combinations, or derivatives. This review provides an up-to-date overview of the positive and negative effects of medicinal cannabis on mental health diagnoses and related symptoms of the Diagnostic and Statistical Manual of Mental Disorders 5th Edition. Searches in PubMed, PsycInfo, Embase, and the Cochrane Library (October 2023 and July 2024) identified 18,341 studies, of which 49 controlled studies from 15 different countries were included. All studies focused on treatment-seeking participants using medicinal cannabis for (symptoms of) their mental health diagnosis. Included diagnoses were anxiety disorders, tic disorders, autism spectrum disorder, attention-deficit hyperactivity disorder, obsessive-compulsive disorders, anorexia nervosa, schizophrenia, psychosis, substance use disorders, insomnia, and bipolar disorders. Varying product compositions showed different effects. Most consistently, high doses of CBD were followed by some acute relief in anxiety, while CBD + THC combinations alleviated withdrawal in cannabis use disorder and improved sleep. In clinical trials, THC was associated most with dose-dependent adverse events and, in some cases, deterioration of primary study outcomes, e.g., in psychosis. In naturalistic studies, participants who used THC reported symptom improvement following usage. Risks of bias across studies were prevalent, and no study found long-lasting medicinal effects or improvement. Overall, medicinal cannabis may provide short-term relief for certain symptoms but is not a cure or without mental health risks.</div></div>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"118 ","pages":"Article 102581"},"PeriodicalIF":13.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-28DOI: 10.1016/j.cpr.2025.102569
Giulia Landi , Kenneth I. Pakenham , Zhangxuan Bao , Roberto Cattivelli , Elisabetta Crocetti , Eliana Tossani , Silvana Grandi
Serious parental physical or mental illness significantly increases the risk of adverse adjustment outcomes in adolescents and young adults. This systematic review and meta-analysis evaluates the efficacy of psychosocial interventions targeting this vulnerable group. Eligible randomized control trials (RCTs) were searched through the Medline, Web of Science, PsycINFO, PsycArticles, Cinahl, and ProQuest Dissertation and Theses databases. Young offspring outcomes included: psychological (including internalizing and externalizing problems), positive, and interpersonal adjustment. Thirty-one manuscripts reporting on twenty-seven independent RCTs, including 3590 adolescent and young adult offspring, met eligibility criteria. Most of the studies targeted adolescents with a mean age within ±1 SD of 12.17–16.33 years, with only one study directly targeting young adults. Three-quarters of studies included parental mental illness, and the remaining parental physical illness. Results highlighted a small post-intervention effect for psychological adjustment (d = 0.17,[0.05,0.29], p = .006), maintained at short-term (3–12 months) follow-up (d = 0.33 [0.12,0.54], p = .002), but not at long-term (15 months or longer) follow-up (d = −0.00 [−0.19,0.19], p = .98). A similar pattern emerged for internalizing problems, while for externalizing problems, no significant post-intervention effect was detected. Results also showed a small post-intervention effect for positive adjustment (d = 0.36,[0.10,0.61], p = .006), which increased to a medium effect at short-term follow-up (d = 0.62,[0.15,1.09], p = .010). Post-intervention effects were not present for interpersonal adjustment. Intervention duration moderated effects on post-intervention outcomes, while intervention setting and gender balance moderated outcomes at follow-ups. Psychosocial interventions for young offspring of parents with serious illnesses appear effective in improving psychological and positive outcomes with small-to-moderate effects at post-intervention and short-term follow-up.
{"title":"Efficacy of psychosocial interventions for young offspring of parents with a serious physical or mental illness: Systematic review and meta-analysis","authors":"Giulia Landi , Kenneth I. Pakenham , Zhangxuan Bao , Roberto Cattivelli , Elisabetta Crocetti , Eliana Tossani , Silvana Grandi","doi":"10.1016/j.cpr.2025.102569","DOIUrl":"10.1016/j.cpr.2025.102569","url":null,"abstract":"<div><div>Serious parental physical or mental illness significantly increases the risk of adverse adjustment outcomes in adolescents and young adults. This systematic review and meta-analysis evaluates the efficacy of psychosocial interventions targeting this vulnerable group. Eligible randomized control trials (RCTs) were searched through the Medline, Web of Science, PsycINFO, PsycArticles, Cinahl, and ProQuest Dissertation and Theses databases. Young offspring outcomes included: psychological (including internalizing and externalizing problems), positive, and interpersonal adjustment. Thirty-one manuscripts reporting on twenty-seven independent RCTs, including 3590 adolescent and young adult offspring, met eligibility criteria. Most of the studies targeted adolescents with a mean age within ±1 SD of 12.17–16.33 years, with only one study directly targeting young adults. Three-quarters of studies included parental mental illness, and the remaining parental physical illness. Results highlighted a small post-intervention effect for psychological adjustment (<em>d</em> = 0.17,[0.05,0.29], <em>p</em> = .006), maintained at short-term (3–12 months) follow-up (<em>d</em> = 0.33 [0.12,0.54], <em>p</em> = .002), but not at long-term (15 months or longer) follow-up (<em>d</em> = −0.00 [−0.19,0.19], <em>p</em> = .98). A similar pattern emerged for internalizing problems, while for externalizing problems, no significant post-intervention effect was detected. Results also showed a small post-intervention effect for positive adjustment (<em>d</em> = 0.36,[0.10,0.61], <em>p</em> = .006), which increased to a medium effect at short-term follow-up (<em>d</em> = 0.62,[0.15,1.09], <em>p</em> = .010). Post-intervention effects were not present for interpersonal adjustment. Intervention duration moderated effects on post-intervention outcomes, while intervention setting and gender balance moderated outcomes at follow-ups. Psychosocial interventions for young offspring of parents with serious illnesses appear effective in improving psychological and positive outcomes with small-to-moderate effects at post-intervention and short-term follow-up.</div></div>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"118 ","pages":"Article 102569"},"PeriodicalIF":13.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-27DOI: 10.1016/j.cpr.2025.102570
Juan Martín Gómez Penedo , Manuel Meglio , Christoph Flückiger , Frederik J. Wienicke , Jasmijn Breunese , Marco Menchetti , Paola Rucci , Robert Johansson , Joel M. Town , Allan A. Abbass , Peter Lilliengren , R. Michael Bagby , Lena C. Quilty , Lotte H.J.M. Lemmens , Suzanne C. van Bronswijk , Michael Barkham , William B. Stiles , Gillian E. Hardy , Peter Fonagy , Patrick Luyten , Ellen Driessen
Objectives
Interpersonal problems are a fundamental feature of depression, but study-level meta-analyses of their association with treatment outcome have been limited by heterogeneity in primary studies' analyses and reported results. We conducted a pre-registered individual participant data meta-analysis (IPD-MA) to examine this relationship for adult depression. This meta-analytic strategy can reduce variability by standardizing data analysis across primary studies.
Methods
We included studies examining the efficacy of five treatments for adult depression and assessing interpersonal problems at baseline. One-stage IPD-MA was conducted with three-level mixed models to determine whether baseline overall interpersonal distress, agency, and communion predicted depressive symptom level at post-treatment, 12-month, and 24-month follow-up. The moderating effect of treatment type was also investigated.
Results
Ten studies (including n = 1282 participants) met inclusion criteria. Only overall interpersonal distress was negatively related with outcomes at post-treatment (γ = 0.11, CI95[0.06, 0.16], r = 0.11), 12-month follow-up (γ = 0.17, CI95[0.08, 0.25], r = 0.17), and 24-month follow-up (γ = 0.16, CI95[0.05, 0.26], r = 0.16), indicative of smaller effect sizes. The agency and communion dimensions were not significantly related to outcome. Treatment type did not significantly moderate interpersonal distress-outcome associations.
Discussion
Results show a small association between patient baseline overall interpersonal distress and subsequent depression treatment outcome in brief treatments for depression. Further studies might require to account for therapist effects.
Registration number osf.io/u46t7
{"title":"Interpersonal problems as a predictor of treatment outcome in adult depression: An individual participant data meta-analysis","authors":"Juan Martín Gómez Penedo , Manuel Meglio , Christoph Flückiger , Frederik J. Wienicke , Jasmijn Breunese , Marco Menchetti , Paola Rucci , Robert Johansson , Joel M. Town , Allan A. Abbass , Peter Lilliengren , R. Michael Bagby , Lena C. Quilty , Lotte H.J.M. Lemmens , Suzanne C. van Bronswijk , Michael Barkham , William B. Stiles , Gillian E. Hardy , Peter Fonagy , Patrick Luyten , Ellen Driessen","doi":"10.1016/j.cpr.2025.102570","DOIUrl":"10.1016/j.cpr.2025.102570","url":null,"abstract":"<div><h3>Objectives</h3><div>Interpersonal problems are a fundamental feature of depression, but study-level meta-analyses of their association with treatment outcome have been limited by heterogeneity in primary studies' analyses and reported results. We conducted a pre-registered individual participant data meta-analysis (IPD-MA) to examine this relationship for adult depression. This meta-analytic strategy can reduce variability by standardizing data analysis across primary studies.</div></div><div><h3>Methods</h3><div>We included studies examining the efficacy of five treatments for adult depression and assessing interpersonal problems at baseline. One-stage IPD-MA was conducted with three-level mixed models to determine whether baseline overall interpersonal distress, agency, and communion predicted depressive symptom level at post-treatment, 12-month, and 24-month follow-up. The moderating effect of treatment type was also investigated.</div></div><div><h3>Results</h3><div>Ten studies (including <em>n</em> = 1282 participants) met inclusion criteria. Only overall interpersonal distress was negatively related with outcomes at post-treatment (<em>γ</em> = 0.11, CI<sub>95</sub>[0.06, 0.16], <em>r</em> = 0.11), 12-month follow-up (<em>γ</em> = 0.17, CI<sub>95</sub>[0.08, 0.25], <em>r</em> = 0.17), and 24-month follow-up (<em>γ</em> = 0.16, CI<sub>95</sub>[0.05, 0.26], <em>r</em> = 0.16), indicative of smaller effect sizes. The agency and communion dimensions were not significantly related to outcome. Treatment type did not significantly moderate interpersonal distress-outcome associations.</div></div><div><h3>Discussion</h3><div>Results show a small association between patient baseline overall interpersonal distress and subsequent depression treatment outcome in brief treatments for depression. Further studies might require to account for therapist effects.</div><div>Registration number osf.io/u46t7</div></div>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"118 ","pages":"Article 102570"},"PeriodicalIF":13.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-26DOI: 10.1016/j.cpr.2025.102571
Urdur Njardvik , Gro Janne Wergeland , Eili N. Riise , Dagmar Kr. Hannesdottir , Lars-Göran Öst
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with estimated worldwide prevalence of 7.2 % in children and adolescents. Comorbidity of psychiatric disorders is considered common in ADHD and has been found to contribute to poorer prognosis. Despite decades of research, the actual prevalence of comorbid psychiatric disorders in children and adolescents with ADHD is unclear. The purpose of this systematic review and meta-analysis was to investigate the prevalence of comorbid disorders in children and adolescents with ADHD. Embase OVID, Ovid MEDLINE and PsycINFO were systematically searched for eligible studies published up to February 2025. In total 121 studies involving 39,894 children and adolescents with ADHD diagnosis were included. The most common comorbid disorders were Oppositional Defiant Disorder (34.7 %), Behavior Disorders (30.7 %), Anxiety Disorders (18.4 %), Specific phobias (11.0 %), Enuresis (10.8 %), and Conduct Disorder (CD) (10.7 %). All individual disorders studied had a higher prevalence among children and adolescents with ADHD than in the general population. Few gender differences were found; higher prevalence of CD among boys and higher of OCD in girls. The findings indicate that comorbid psychiatric disorders are highly prevalent in children and adolescents with ADHD and must be considered in both assessment and treatment of ADHD.
PROSPERO registration: ID CRD42022359965.
{"title":"Psychiatric comorbidity in children and adolescents with ADHD: A systematic review and meta-analysis","authors":"Urdur Njardvik , Gro Janne Wergeland , Eili N. Riise , Dagmar Kr. Hannesdottir , Lars-Göran Öst","doi":"10.1016/j.cpr.2025.102571","DOIUrl":"10.1016/j.cpr.2025.102571","url":null,"abstract":"<div><div>Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with estimated worldwide prevalence of 7.2 % in children and adolescents. Comorbidity of psychiatric disorders is considered common in ADHD and has been found to contribute to poorer prognosis. Despite decades of research, the actual prevalence of comorbid psychiatric disorders in children and adolescents with ADHD is unclear. The purpose of this systematic review and meta-analysis was to investigate the prevalence of comorbid disorders in children and adolescents with ADHD. Embase OVID, Ovid MEDLINE and PsycINFO were systematically searched for eligible studies published up to February 2025. In total 121 studies involving 39,894 children and adolescents with ADHD diagnosis were included. The most common comorbid disorders were Oppositional Defiant Disorder (34.7 %), Behavior Disorders (30.7 %), Anxiety Disorders (18.4 %), Specific phobias (11.0 %), Enuresis (10.8 %), and Conduct Disorder (CD) (10.7 %). All individual disorders studied had a higher prevalence among children and adolescents with ADHD than in the general population. Few gender differences were found; higher prevalence of CD among boys and higher of OCD in girls. The findings indicate that comorbid psychiatric disorders are highly prevalent in children and adolescents with ADHD and must be considered in both assessment and treatment of ADHD.</div><div>PROSPERO registration: ID CRD42022359965.</div></div>","PeriodicalId":48458,"journal":{"name":"Clinical Psychology Review","volume":"118 ","pages":"Article 102571"},"PeriodicalIF":13.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}