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Morphogen rules: design principles of gradient-mediated embryo patterning. 形态发生器规则:梯度介导的胚胎形态设计原则。
1区 经济学 Q1 ECONOMICS Pub Date : 2015-12-01 DOI: 10.1242/dev.129452
James Briscoe, Stephen Small

The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of morphogen-patterned tissues that create precise spatial patterns of different cell types. In both tissues, pattern formation is dependent on molecular gradients that emanate from opposite poles. Despite distinct evolutionary origins and differences in time scales, cell biology and molecular players, both tissues exhibit striking similarities in the regulatory systems that establish gene expression patterns that foreshadow the arrangement of cell types. First, signaling gradients establish initial conditions that polarize the tissue, but there is no strict correspondence between specific morphogen thresholds and boundary positions. Second, gradients initiate transcriptional networks that integrate broadly distributed activators and localized repressors to generate patterns of gene expression. Third, the correct positioning of boundaries depends on the temporal and spatial dynamics of the transcriptional networks. These similarities reveal design principles that are likely to be broadly applicable to morphogen-patterned tissues.

果蝇的胚泡和脊椎动物的神经管是形态发生器模式化组织的典型例子,它们创造了不同细胞类型的精确空间模式。在这两种组织中,模式的形成都依赖于来自两极的分子梯度。尽管进化起源不同,时间尺度、细胞生物学和分子参与者也不同,但这两种组织在建立预示细胞类型排列的基因表达模式的调控系统方面表现出惊人的相似性。首先,信号梯度建立了使组织极化的初始条件,但特定形态发生阈值和边界位置之间没有严格的对应关系。其次,梯度启动转录网络,整合广泛分布的激活剂和局部的抑制剂,从而产生基因表达模式。第三,边界的正确定位取决于转录网络的时空动态。这些相似之处揭示了可能广泛适用于形态发生器模式组织的设计原则。
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引用次数: 0
Financial Asset Holdings and Political Attitudes: Evidence from Revolutionary England* 金融资产持有与政治态度:来自英国革命的证据*
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2015-08-01 DOI: 10.1093/QJE/QJV019
Saumitra Jha
The English Parliament’s struggle for supremacy against monarchical dictatorship during the Civil War (1642–1648) was crucial for the establishment of representative government, yet its lessons continue to be debated. I exploit novel data on individual MPs drawn from 1,842 biographies to show that the conflict was over overseas interests and other factors over which the executive enjoyed broad constitutional discretion, rather than over domestic property rights. I further exploit the coincidence of individual MPs’ ability to sign legally binding share contracts with novel share offerings by overseas companies to measure the effect of overseas share investment on their political attitudes. I show that overseas shareholding pushed moderates lacking prior mercantile interests to support reform. I interpret the effect of financial assetholding as allowing new investors to exploit emerging economic opportunities overseas, aligning their interests with traders. By consolidating a broad parliamentary majority that favored reform, the introduction of financial assets also broadened support for the institutionalization of parliamentary supremacy over dictatorial rule. JEL Codes: O10, G11, F10, K00, N23, P10.
英国议会在内战(1642-1648)期间与君主独裁政权争夺最高权力的斗争对代议制政府的建立至关重要,但其教训仍在争论中。我利用了从1842本国会议员传记中获取的有关个别议员的新数据,以表明冲突是围绕海外利益和其他因素,而不是围绕国内产权,行政部门在这些因素上享有广泛的宪法自由裁量权。我进一步利用个别国会议员签署具有法律约束力的股票合同的能力与海外公司的新股票发行的巧合来衡量海外股票投资对他们政治态度的影响。我指出,海外持股促使缺乏商业利益的温和派支持改革。我认为,金融资产的影响是允许新投资者利用海外新兴经济机会,使他们的利益与交易员保持一致。通过巩固支持改革的议会多数,金融资产的引入也扩大了对议会至高无上的制度化的支持,而不是独裁统治。JEL代码:O10、G11、F10、K00、N23、P10。
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引用次数: 43
Property Rights over Marital Transfers 婚姻财产转移中的产权问题
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2015-08-01 DOI: 10.1093/QJE/QJV014
Siwan Anderson, Chris Bidner
In developing countries, the extent to which women possess property rights is shaped in large part by transfers received at the time of marriage. Focusing on dowry, we develop a simple model of the marriage market with intra-household bargaining in order to understand the incentives for brides’ parents to allocate the rights over the dowry between their daughter and her groom. In doing so, we clarify and formalize the ‘dual role’ of dowry ‐ as a pre-mortem bequest and as a market clearing price ‐ identified in the literature. We use the model to shed light on the intriguing observation that, in contrast to other rights, women’s rights over the dowry tend to deteriorate with development. We show how marriage payments are utilized even when they are inefficient, and how the marriage market mitigates changes in other dimensions of women’s rights even to the point where women are worse off following a strengthening of such rights. We also generate predictions for when marital transfers will disappear and highlight the importance of female human capital for the welfare of women.
在发展中国家,妇女拥有财产权利的程度在很大程度上取决于结婚时收到的转移。以嫁妆为重点,我们建立了一个简单的家庭内部讨价还价的婚姻市场模型,以了解新娘父母在女儿和新郎之间分配嫁妆权利的动机。在这样做的过程中,我们澄清并正式化了嫁妆的“双重角色”——作为死前遗赠和作为市场清算价格——在文献中已经确定。我们用这个模型揭示了一个有趣的现象,即与其他权利相比,妇女对嫁妆的权利往往随着发展而恶化。我们展示了婚姻报酬是如何在效率低下的情况下被利用的,以及婚姻市场是如何减缓妇女权利其他方面的变化的,甚至在这些权利得到加强之后,妇女的处境变得更糟。我们还预测了婚姻转移何时会消失,并强调了女性人力资本对女性福利的重要性。
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引用次数: 76
Education and Human Capital Externalities: Evidence from Colonial Benin 教育与人力资本外部性:来自贝宁殖民地的证据
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2015-05-01 DOI: 10.1093/QJE/QJV004
Léonard Wantchékon, Marko Klašnja, Natalija Novta
colonial Benin, we investigate the effect of education on living standards, occupation, and political participation. Since both school locations and student cohorts were selected with very little information, treatment and control groups are balanced on observables. We can therefore estimate the effect of education by comparing the treated to the untreated living in the same village, as well as those living in villages where no schools were set up. We find a significant positive treatment effect of education for the first generation of students, as well as their descendants: they have higher living standards, are less likely to be farmers, and are more likely to be politically active. We find large village-level externalities—descendants of the uneducated in villages with schools do better than those in control villages. We also find extended family externalities—nephews and nieces directly benefit from their uncle’s education—and show that this represents a ‘‘family tax,’’ as educated uncles transfer resources to the extended family.
我们调查了教育对生活水平、职业和政治参与的影响。由于学校地点和学生群体都是在信息很少的情况下选择的,因此治疗组和对照组在观察结果上是平衡的。因此,我们可以通过比较生活在同一村庄的接受教育的人与未接受教育的人,以及生活在没有建立学校的村庄的人,来估计教育的效果。我们发现教育对第一代学生及其后代有显著的正向治疗作用:他们的生活水平更高,成为农民的可能性更小,在政治上更活跃。我们发现了很大的村级外部性——在有学校的村庄里,未受过教育的人的后代比对照村的人表现得更好。我们还发现了大家庭的外部性——侄子和侄女直接受益于他们叔叔的教育——并表明这代表了一种“家庭税”,因为受过教育的叔叔将资源转移给了大家庭。
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引用次数: 223
Spending-Biased Legislators: Discipline Through Disagreement 有支出偏见的立法者:通过分歧来约束
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2015-05-01 DOI: 10.1093/QJE/QJV011
F. Piguillem, Alessandro Riboni
We study legislators who have a present bias for spending: they want to increase current spending and procrastinate spending cuts. We show that disagreement in legislatures can lead to policy persistence that attenuates the temptation to overspend. Depending on the environment, legislators’ decisions to be fiscally responsible may either complement or substitute other legislators’ decisions. When legislators have low discount factors, their actions are strategic complements. Thus, changes of the political environment that induce fiscal responsibility are desirable as they generate a positive responsibility multiplier and reduce spending. However, when the discount factor is high, the same changes induce some legislators to free ride on others’ responsibility which may lead to higher spending. JEL Codes: D72-H00.
我们研究那些对支出有当前偏见的立法者:他们想增加当前支出,拖延削减支出。我们表明,立法机构的分歧可能导致政策持久性,从而减弱过度支出的诱惑。根据环境的不同,立法者的财政负责的决定可以补充或替代其他立法者的决定。当立法者的贴现因子较低时,他们的行为是战略补充。因此,诱导财政责任的政治环境的变化是可取的,因为它们产生积极的责任乘数并减少支出。然而,当折扣系数很高时,同样的变化会诱使一些立法者搭便车,从而可能导致更高的支出。JEL代码:D72-H00。
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引用次数: 27
The Value of Hiring through Employee Referrals 通过员工推荐招聘的价值
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2015-05-01 DOI: 10.1093/QJE/QJV010
S. Burks, Bo Cowgill, M. Hoffman, M. Housman
Using personnel data from nine large firms in three industries (call centers, trucking, and high-tech), we empirically assess the benefit to firms of hiring through employee referrals. Compared to nonreferred applicants, referred applicants are more likely to be hired and more likely to accept offers, even though referrals and nonreferrals have similar skill characteristics. Referred workers tend to have similar productivity compared to nonreferred workers on most measures, but referred workers have lower accident rates in trucking and produce more patents in high-tech. Referred workers are substantially less likely to quit and earn slightly higher wages than nonreferred workers. In call centers and trucking, the two industries for which we can calculate worker-level profits, referred workers yield substantially higher profits per worker than nonreferred workers. These profit differences are driven by lower turnover and lower recruiting costs for referrals. JEL Codes: J24, M51, J30, J63.
利用来自三个行业(呼叫中心、卡车运输和高科技)的九家大公司的人事数据,我们实证地评估了通过员工推荐招聘给公司带来的好处。与未被推荐的求职者相比,被推荐的求职者更有可能被聘用,也更有可能接受工作邀请,尽管推荐和未被推荐的求职者具有相似的技能特征。在大多数衡量标准上,被推荐的工人往往与未被推荐的工人有着相似的生产率,但被推荐的工人在卡车运输方面的事故率更低,在高科技领域获得了更多的专利。被推荐的员工基本上不太可能辞职,而且工资略高于未被推荐的员工。在呼叫中心和卡车运输这两个我们可以计算工人层面利润的行业中,被推荐的工人比未被推荐的工人的人均利润高得多。这些利润差异是由较低的人员流动率和较低的推荐招聘成本驱动的。JEL代码:J24, M51, J30, J63。
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引用次数: 227
The Psychological Effect of Weather on Car Purchases 天气对购车的心理影响
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2015-02-01 DOI: 10.1093/QJE/QJU033
Meghan R. Busse, Devin G. Pope, Jaren C. Pope, Jorge M. Silva-Risso
When buying durable goods, consumers must forecast how much utility they will derive from future consumption, including consumption in different states of the world. This can be complicated for consumers because making intertemporal evaluations may expose them to a variety of psychological biases such as present bias, projection bias, and salience effects. We investigate whether consumers are affected by such intertemporal biases when they purchase automobiles. Using data for more than 40 million vehicle transactions, we explore the impact of weather on purchasing decisions. We find that the choice to purchase a convertible or a four-wheel-drive is highly dependent on the weather at the time of purchase in a way that is inconsistent with classical utility theory. We consider a range of rational explanations for the empirical effects we find, but none can explain fully the effects we estimate. We then discuss and explore projection bias and salience as two primary psychological mechanisms that are consistent with our results. JEL Codes: D03; D12.
在购买耐用品时,消费者必须预测他们将从未来消费中获得多少效用,包括在世界不同状态下的消费。这对消费者来说可能很复杂,因为进行跨期评估可能会使他们暴露于各种心理偏见,如当前偏见、投射偏见和显著性效应。我们调查了消费者在购买汽车时是否受到这种跨期偏差的影响。利用超过4000万辆汽车交易的数据,我们探讨了天气对购买决策的影响。我们发现,购买敞篷车还是四轮驱动的选择高度依赖于购买时的天气,这与经典效用理论不一致。对于我们发现的经验效应,我们考虑了一系列合理的解释,但没有一个能完全解释我们估计的效应。然后,我们讨论和探索投射偏差和显著性作为与我们的结果一致的两种主要心理机制。JEL代码:D03;D12。
{"title":"The Psychological Effect of Weather on Car Purchases","authors":"Meghan R. Busse, Devin G. Pope, Jaren C. Pope, Jorge M. Silva-Risso","doi":"10.1093/QJE/QJU033","DOIUrl":"https://doi.org/10.1093/QJE/QJU033","url":null,"abstract":"When buying durable goods, consumers must forecast how much utility they will derive from future consumption, including consumption in different states of the world. This can be complicated for consumers because making intertemporal evaluations may expose them to a variety of psychological biases such as present bias, projection bias, and salience effects. We investigate whether consumers are affected by such intertemporal biases when they purchase automobiles. Using data for more than 40 million vehicle transactions, we explore the impact of weather on purchasing decisions. We find that the choice to purchase a convertible or a four-wheel-drive is highly dependent on the weather at the time of purchase in a way that is inconsistent with classical utility theory. We consider a range of rational explanations for the empirical effects we find, but none can explain fully the effects we estimate. We then discuss and explore projection bias and salience as two primary psychological mechanisms that are consistent with our results. JEL Codes: D03; D12.","PeriodicalId":48470,"journal":{"name":"Quarterly Journal of Economics","volume":"130 1","pages":"371-414"},"PeriodicalIF":13.7,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/QJE/QJU033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61199887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 202
The Impact of Housing Assistance on Child Outcomes: Evidence from a Randomized Housing Lottery 住房援助对儿童结局的影响:来自随机住房摇号的证据
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2015-02-01 DOI: 10.1093/QJE/QJU030
B. Jacob, Max Kapustin, J. Ludwig
One long-standing motivation for low-income housing programs is the possibility that housing affordability and housing conditions generate externalities, including on children’s behavior and long-term life outcomes. We take advantage of a randomized housing voucher lottery in Chicago in 1997 to examine the long-term impact of housing assistance on a wide variety of child outcomes, including schooling, health, and criminal involvement. In contrast to most prior work focusing on families in public housing, we focus on families living in unsubsidized private housing at baseline, for whom voucher receipt generates large changes in both housing and nonhousing consumption. We find that the receipt of housing assistance has little, if any, impact on neighborhood or school quality or on a wide range of important child outcomes. JEL Codes: D10, H23, I38.
低收入住房项目的一个长期动机是住房负担能力和住房条件可能产生外部性,包括对儿童行为和长期生活结果的影响。我们利用1997年芝加哥的随机住房券抽奖来研究住房援助对各种儿童结果的长期影响,包括上学、健康和犯罪行为。与之前大多数关注公共住房家庭的工作相反,我们关注的是生活在无补贴私人住房的家庭,他们的代金券收据在住房和非住房消费方面都产生了很大的变化。我们发现,接受住房援助对社区或学校质量或对广泛的重要儿童成果的影响很小,如果有的话。JEL代码:D10, H23, I38。
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引用次数: 108
Evidence on Self-Stereotyping and the Contribution of Ideas 自我刻板印象的证据和思想的贡献
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2014-11-01 DOI: 10.1093/QJE/QJU023
K. Coffman
We use a lab experiment to explore the factors that predict an individual’s decision to contribute her idea to a group. We find that contribution decisions depend on the interaction of gender and the gender stereotype associated with the decision-making domain: conditional on measured ability, individuals are less willing to contribute ideas in areas that are stereotypically outside of their gender’s domain. Importantly, these decisions are largely driven by self-assessments, rather than fear of discrimination. Individuals are less confident in gender-incongruent areas and are thus less willing to contribute their ideas. Because even very knowledgeable group members undercontribute in gender-incongruent categories, group performance suffers and, ex post, groups have difficulty recognizing who their most talented members are. Our results show that even in an environment where other group members show no bias, women in male-typed areas and men in female-typed areas may be less influential. An intervention that provides feedback about a woman’s (man’s) strength in a male-typed (female-typed) area does not significantly increase the probability that she contributes her ideas to the group. A back-of-the-envelope calculation reveals that a “lean in”–style policy that increases contribution by women would significantly improve group performance in male-typed domains. JEL Codes: J16, C92.
我们使用实验室实验来探索预测个人决定将其想法贡献给团队的因素。我们发现,贡献决策取决于与决策领域相关的性别和性别刻板印象的相互作用:在测量能力的条件下,个人不太愿意在其性别领域之外的刻板印象中贡献想法。重要的是,这些决定很大程度上是由自我评估驱动的,而不是对歧视的恐惧。个人在性别不一致的领域缺乏自信,因此不太愿意贡献自己的想法。因为即使是非常有知识的小组成员在性别不一致的类别中贡献不足,小组的表现也会受到影响,而且在此之后,小组很难识别谁是最有才华的成员。我们的研究结果表明,即使在其他群体成员没有表现出偏见的环境中,女性在男性类型领域和男性在女性类型领域的影响力也可能较小。对女性(男性)在男性类型(女性类型)领域的能力提供反馈的干预并不会显著增加她为团队贡献想法的可能性。一项粗略的计算表明,“向前一步”式的政策,增加女性的贡献,将显著提高男性主导领域的群体表现。JEL代码:J16, C92。
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引用次数: 218
Extensive Imitation is Irrational and Harmful 过度模仿是不合理的,也是有害的
IF 13.7 1区 经济学 Q1 ECONOMICS Pub Date : 2014-11-01 DOI: 10.1093/QJE/QJU021
Erik Eyster, M. Rabin
Rationality leads people to imitate those with similar tastes but different information. But people who imitate common sources develop correlated beliefs, and rationality demands that later social learners take this redundancy into account. This implies severe limits to rational imitation. We show that (i) in most natural observation structures besides the canonical single-file case, full rationality dictates that people must anti-imitate" some of those they observe; and (ii) in every observation structure full rationality dictates that people who do not anti-imitate can, in essence, imitate at most one person among predecessors who share common information. We also show that in a very broad class of settings, virtually any learning rule in which people regularly do imitate more than one person without anti-imitating others will lead to a positive (and, in some environments, arbitrarily high) probability of people converging to confident and wrong long-run beliefs. When testing either the rationality or the efficiency of social learning, researchers should not focus on whether people follow others' behaviour but instead whether they follow it too much.
理性导致人们模仿那些品味相似但信息不同的人。但模仿共同来源的人会形成相关的信念,理性要求后来的社会学习者考虑到这种冗余。这意味着对理性模仿的严格限制。我们表明(i)在大多数自然观察结构中,除了典型的单文件情况,充分理性决定了人们必须“反模仿”他们观察到的一些;(ii)在每个观察结构中,充分理性决定了不反模仿的人本质上最多只能模仿共享共同信息的前辈中的一个人。我们还表明,在一个非常广泛的环境中,几乎任何学习规则,如果人们经常模仿不止一个人,而不反对模仿其他人,都会导致人们倾向于自信和错误的长期信念的积极(在某些环境中,这是任意高的)可能性。在测试社会学习的合理性或效率时,研究人员不应该关注人们是否遵循他人的行为,而应该关注他们是否过度遵循他人的行为。
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引用次数: 93
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Quarterly Journal of Economics
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