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Factors affecting iron absorption and the role of fortification in enhancing iron levels. 影响铁吸收的因素及强化在提高铁水平中的作用。
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-12-01 Epub Date: 2023-11-15 DOI: 10.1111/nbu.12643
Dipun Nirmal Perera, Chathurangi Lakshika Palliyaguruge, Dasuni Dilkini Eapasinghe, Dilmi Maleesha Liyanage, R A C Haily Seneviratne, S M D Demini, J A S M Jayasinghe, Mishal Faizan, Umapriyatharshini Rajagopalan, B Prasanna Galhena, Hasi Hays, Kanishka Senathilake, Kamani H Tennekoon, Sameera R Samarakoon
Iron is an important micronutrient required for a number of biological processes including oxygen transport, cellular respiration, the synthesis of nucleic acids and the activity of key enzymes. The World Health Organization has recognised iron deficiency as the most common nutritional deficiency globally and as a major determinant of anaemia. Iron deficiency anaemia affects 40% of all children between the ages of 6 and 59 months, 37% of mothers who are pregnant and 30% of women between the ages of 15 and 49 years worldwide. Dietary iron exists in two main forms known as haem iron and non-haem iron. Haem iron is obtained from animal sources such as meat and shows higher bioavailability than non-haem iron, which can be obtained from both plant and animal sources. Different components in food can enhance or inhibit iron absorption from the diet. Components such as meat proteins and organic acids increase iron absorption, while phytate, calcium and polyphenols reduce iron absorption. Iron levels in the body are tightly regulated since both iron overload and iron deficiency can exert harmful effects on human health. Iron is stored mainly as haemoglobin and as iron bound to proteins such as ferritin and hemosiderin. Iron deficiency affects individuals at increased risk due to factors such as age, pregnancy, menstruation and various diseases. Different solutions for iron deficiency are applied at individual and community levels. Iron supplements and intravenous iron can be used to treat individuals with iron deficiency, while various types of iron-fortified foods and biofortified crops can be employed for larger communities. Foods such as rice, flour and biscuits have been used to prepare fortified iron products. However, it is important to ensure the fortification process does not exert significant negative effects on organoleptic properties and the shelf life of the food product.
铁是许多生物过程所需的重要微量营养素,包括氧运输、细胞呼吸、核酸合成和关键酶的活性。世界卫生组织已确认缺铁是全球最常见的营养缺乏症,也是贫血的主要决定因素。缺铁性贫血影响全世界40%的6至59个月儿童、37%的孕妇母亲和30%的15至49岁妇女。膳食铁主要以血红素铁和非血红素铁两种形式存在。血红素铁可从肉类等动物来源获得,其生物利用度高于非血红素铁,后者可从植物和动物来源获得。食物中的不同成分可以增强或抑制铁的吸收。肉类蛋白质和有机酸等成分会增加铁的吸收,而植酸盐、钙和多酚则会减少铁的吸收。体内的铁含量受到严格的调节,因为铁超载和缺铁都会对人体健康产生有害影响。铁主要以血红蛋白的形式储存,并与铁蛋白和含铁血黄素等蛋白质结合。由于年龄、怀孕、月经和各种疾病等因素,缺铁会增加个体的风险。针对缺铁问题,在个人和社区层面采用了不同的解决办法。铁补充剂和静脉注射铁可用于治疗缺铁的个人,而各种类型的铁强化食品和生物强化作物可用于较大的社区。大米、面粉和饼干等食物被用来制作强化铁制品。然而,重要的是要确保强化过程不会对食品的感官特性和保质期产生重大的负面影响。
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引用次数: 0
Changes in dietary carbohydrate and lipid quality indices between 2008 and 2018: Analysis of the Brazilian dietary surveys. 2008年至2018年间饮食碳水化合物和脂质质量指数的变化:巴西饮食调查分析。
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-12-01 Epub Date: 2023-10-30 DOI: 10.1111/nbu.12641
Luciana Guerra Cardoso, Luana Silva Monteiro, Rosely Sichieri, Edna Massae Yokoo, Rosângela Alves Pereira

The aim of the study was to evaluate characteristics and changes over a decade in dietary carbohydrate and lipid quality according to socio-demographic variables. Data was obtained from two Brazilian National Dietary Surveys 2008-2009 (n = 34 003) and 2017-2018 (n = 46 164) examining a nationwide representative sample of individuals ≥10 years old. Food intake was assessed by means of two non-consecutive diet records (2008-2009) and 24 h diet recalls (2017-2018). Carbohydrate Quality Index is a score ranging from 4 to 20 calculated from fibre intake, global dietary glycaemic index, solid/total carbohydrate (CHO) and whole grains/total grains CHO. Lipid Quality Index was estimated by dividing the sum of the dietary content of monounsaturated and polyunsaturated fatty acids by the sum of saturated and trans fatty acids. Indices were categorised into five categories (1 for lowest and 5 for highest quality). Socio-demographic variables were sex, age, income, urban/rural area and place of food consumption. The estimates (95% CI) were generated separately for each survey and then compared to identify changes in time. Our main findings refer to changes in diet quality according to income. At the lowest income level, the proportions of individuals in the best carbohydrate and lipid quality categories reduced from 26.9% to 20.6% and from 30.0% to 24.9%, respectively. Alternatively, at the highest income level, these proportions increased from 22.9% to 26.6% and from 11.9% to 15.7%, respectively. Furthermore, the quality of lipids improved in women and among individuals reporting some away-from-home food consumption, while the quality of carbohydrates was reduced among adolescents and in rural areas.

该研究的目的是根据社会人口统计变量,评估十年来饮食碳水化合物和脂质质量的特征和变化。数据来自2008-2009年两次巴西全国膳食调查(n = 34 003)和2017-2018(n = 46 164)检查全国代表性样本中≥10人 岁通过两个非连续饮食记录(2008-2009年)和24 h饮食召回(2017-2018)。碳水化合物质量指数是根据纤维摄入量、全球饮食血糖指数、固体/总碳水化合物(CHO)和全谷物/总谷物CHO计算得出的4至20分。通过将膳食中单不饱和和多不饱和脂肪酸含量的总和除以饱和和反式脂肪酸的总和来估计脂质质量指数。指数分为五类(1类代表最低质量,5类代表最高质量)。社会人口变量包括性别、年龄、收入、城市/农村地区和食品消费地。每次调查的估计值(95%置信区间)分别生成,然后进行比较以确定时间变化。我们的主要发现涉及到饮食质量随收入的变化。在最低收入水平,碳水化合物和脂质质量最好的人群比例分别从26.9%降至20.6%和从30.0%降至24.9%。或者,在最高收入水平,这一比例分别从22.9%上升到26.6%和从11.9%上升到15.7%。此外,妇女和报告有一些外出食品消费的人的脂质质量有所改善,而青少年和农村地区的碳水化合物质量有所下降。
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引用次数: 0
Increasing fibre in white flour and bread: Implications for health and processing. 增加白面粉和面包中的纤维:对健康和加工的影响。
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-12-01 Epub Date: 2023-10-31 DOI: 10.1111/nbu.12648
Peter R Shewry, Edward J M Joy, Lucia Segovia De La Revilla, Annalene Hansen, Joe Brennan, Alison Lovegrove

Dietary fibre is beneficial for human health, but dietary intakes are below recommended levels in most countries. Cereals are the major source of dietary fibre in Western diets, with bread providing about 20% of the daily intake in the United Kingdom. Despite the promotion of fibre-rich wholegrain products, white bread (which has a lower fibre content) remains dominant in many countries due to cultural preferences. Increasing the fibre content of white bread and other products made from white flour is therefore an attractive strategy for increasing fibre intake. This can be achieved by exploiting genetic variation in wheat without major effects on the processing quality or the consumer acceptability of products. Modelling data for food consumption in the United Kingdom shows that increasing the fibre content of white flour by 50% (from about 4% to 6% dry weight) and in wholegrain by 20% will increase total fibre intake by 1.04 g/day and 1.41 g/day in adult females and males, respectively. Furthermore, in vitro studies indicate that the increased fibre content of white bread should reduce the rate of starch digestion and glucose release in the human gastrointestinal tract.

膳食纤维对人体健康有益,但在大多数国家,膳食摄入量低于建议水平。谷物是西方饮食中膳食纤维的主要来源,在英国,面包约占每日摄入量的20%。尽管推广富含纤维的全麦产品,但由于文化偏好,白面包(纤维含量较低)在许多国家仍然占主导地位。因此,增加白面包和其他由白面粉制成的产品的纤维含量是增加纤维摄入量的一个有吸引力的策略。这可以通过利用小麦的遗传变异来实现,而不会对产品的加工质量或消费者可接受性产生重大影响。英国食品消费的建模数据显示,将白面粉的纤维含量增加50%(从干重的4%增加到6%),将全谷物的纤维含量提高20%,将使总纤维摄入量增加1.04 g/天和1.41 成年雌性和雄性分别为g/天。此外,体外研究表明,白面包纤维含量的增加会降低人体胃肠道中淀粉的消化率和葡萄糖的释放率。
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引用次数: 0
Eliminating industrially produced trans fats from our diet-How well is it going? 从我们的饮食中消除工业生产的反式脂肪效果如何?
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-12-01 Epub Date: 2023-11-10 DOI: 10.1111/nbu.12647
Johanna Helen Bruce
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引用次数: 0
"Taking from Peter to pay Paul": The experience of people in receipt of fuel and food vouchers from a UK foodbank. “拆东墙补西墙”:从英国食品银行领取燃料和食品券的人们的经历。
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-12-01 Epub Date: 2023-09-18 DOI: 10.1111/nbu.12639
Sarah Hanson, Pippa Belderson, Emily Player, Anne-Marie Minihane, Anna Sweeting

For people on very low incomes, household fuel and food environments are increasingly uncertain. Many live in precarious situations with little control over their lives. In addition to food parcels, many foodbanks also supply emergency fuel payments. There has been a surge in demand due to the cost of living crisis in the United Kingdom. This qualitative study, using semi-structured interviews, explored the lived experience of people who received a fuel voucher via a foodbank to gain insights into food preparation, eating practices and heating and appliance use in their homes. All participants (n = 6) described a change in life circumstances leaving them at crisis point with overwhelming uncertainty. Using Thematic Analysis, we identified four themes: (1) Bewilderment in using foodbank services; (2) The need to make trade-offs between food and fuel; (3) Feeling shame at using the services and (4) Missing out on pleasurable eating practices. Three case studies give fuller insights and context. All interviewees had acute and complex needs and described being 'at rock bottom', with fuel vouchers viewed as a 'lifeline' to address essential cooking, heating and electrical appliance needs. We, therefore, suggest the need for extra support and follow-up for first-time users who are in a state of denial and shock when seeking help. Further research is needed on how to best help organisations develop strategies to address and ameliorate a sense of powerlessness and shame felt by their clients which likely limits them from seeking help, despite being in acute, complex and dire need.

对于收入极低的人来说,家庭燃料和食品环境越来越不确定。许多人生活在不稳定的环境中,几乎无法控制自己的生活。除了食品包裹外,许多食品银行还提供紧急燃料支付。由于英国的生活成本危机,需求激增。这项定性研究采用半结构化访谈,探讨了通过食品银行获得燃料券的人们的生活经历,以深入了解他们家中的食物准备、饮食习惯、供暖和电器使用情况。所有参与者(n = 6)都描述了生活环境的变化使他们处于危机点,充满了巨大的不确定性。使用主题分析,我们确定了四个主题:(1)使用食物银行服务的困惑;(2)需要在食物和燃料之间进行权衡;(3)对使用这些服务感到羞耻;(4)错过了愉快的饮食习惯。三个案例研究提供了更全面的见解和背景。所有受访者都有紧迫而复杂的需求,并形容自己处于“最底层”,燃料券被视为满足基本烹饪、取暖和电器需求的“生命线”。因此,我们建议,对于在寻求帮助时处于否认和震惊状态的首次使用者,需要额外的支持和跟踪。需要进一步研究如何最好地帮助组织制定策略来解决和改善客户的无力感和羞耻感,尽管他们有迫切、复杂和迫切的需求,但这种感觉可能会限制他们寻求帮助。
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引用次数: 0
Comparing product healthiness according to the Health Star Rating and the NOVA classification system and implications for food labelling systems: An analysis of 25 486 products in Australia. 根据健康之星评级和NOVA分类系统比较产品健康状况及其对食品标签系统的影响:25项分析 486种产品。
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-12-01 Epub Date: 2023-10-28 DOI: 10.1111/nbu.12640
Eden M Barrett, Allison Gaines, Daisy H Coyle, Simone Pettigrew, Maria Shahid, Damian Maganja, Alexandra Jones, Mike Rayner, Dariush Mozaffarian, Fraser Taylor, Nadine Ghammachi, Jason H Y Wu

We investigated the extent of alignment between 'healthiness' defined by a food classification system that classifies foods and beverages primarily by their nutrient composition, the Health Star Rating (HSR) and a system that considers only the degree of processing of the product, the NOVA classification system. We used data for 25 486 products contained within the George Institute for Global Health's Australian 2022 FoodSwitch Dataset. Agreement between the two systems in the proportion of products classified as 'healthier' (HSR ≥3.5 or NOVA group 1-3) or 'less healthy' (HSR <3.5 or NOVA group 4) was assessed using the κ statistic. There was 'fair' agreement (κ = 0.30, 95%CI: 0.29-0.31) between both systems in the proportion of all products classified as healthier or less healthy. Approximately one-third (n = 8729) of all products were defined as 'discordant', including 34.3% (n = 5620) of NOVA group 4 products with HSR ≥3.5 (commonly convenience foods, sports/diet foods, meat alternatives, as well as products containing non-sugar sweeteners) and 34.1% (n = 3109) of NOVA group 1-3 products with HSR <3.5 (commonly single-ingredient foods such as sugars/syrups, full-fat dairy and products specially produced to contain no ultra-processed ingredients). Our analysis strengthens the evidence for the similarities and differences in product healthiness according to a nutrient-based classification system and a processing-based classification system. Although the systems' classifications align for the majority of food and beverage products, the discordance found for some product categories indicates potential for confusion if systems are deployed alongside each other within food policies.

我们调查了食品分类系统定义的“健康度”与仅考虑产品加工程度的系统NOVA分类系统之间的一致程度,该系统主要根据食品和饮料的营养成分对其进行分类,即健康星级评定(HSR)。我们使用了25 乔治全球健康研究所2022年澳大利亚食品开关数据集中包含486种产品。两个系统在分类为“更健康”(HSR≥3.5或NOVA 1-3组)或“不太健康”(高铁
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引用次数: 0
Evaluation of the deficiency status of 25-hydroxyvitamin D and associated factors in Southwest China: A hospital-based retrospective cross-sectional analysis of a low-latitude, high-altitude, multiracial region. 中国西南地区25-羟基维生素D缺乏状况及相关因素的评估:一项基于医院的低纬度、高海拔、多种族地区的回顾性横断面分析。
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-12-01 Epub Date: 2023-10-21 DOI: 10.1111/nbu.12645
Ying Chan, Dongling Cai, Rongfen Guo, Xiaoyan Zhou, Guangyu He, Huiping Li, Zibiao Geng, Yan Guo, Junyue Lin, Ruihong Wang, Lihong Jiang, Baosheng Zhu

Vitamin D deficiency is widespread in different populations and regions worldwide and has become a global health issue. The vitamin D status of the population in the Yunnan Province of Southwest China has not been evaluated to date. Therefore, in this study, we evaluated the vitamin D status according to the serum concentrations of 25-hydroxyvitamin D (25(OH)D) in individuals of Yunnan Province, a low-latitude, high-altitude and multiracial region in China. The data on 25(OH)D concentrations from October 2012 to December 2017 were retrospectively collected and assessed using the laboratory information system from 52 950 hospital-based participants (age, 1 day-96 years; females, 73.74%). The serum concentration of 25(OH)D was evaluated using a chemiluminescent immunoassay. The analysis was stratified by sex, age, sampling season, testing year, minority, residential district, latitude, altitude and meteorological factors. Vitamin D status was classified as follows: severe deficiency: <10 ng/mL; deficiency: <20 ng/mL; insufficiency: <30 ng/mL; and sufficiency: ≥30 ng/mL. The results showed that vitamin D deficiency is highly prevalent in Yunnan Province in a hospital-based cohort, with a deficiency and severe deficiency rate of 65.1% and a sufficiency rate of 5.30%. Significantly lower vitamin D levels and sufficiency rates were observed in females than in males (20.13 ± 7.22 ng/mL vs. 17.56 ± 6.66 ng/mL and 8.20% vs. 4.20%; p < 0.01, respectively); in spring and winter (16.93 ± 6.24 ng/mL; 2.97% and 16.38 ± 6.43 ng/mL; 3.06%, respectively) than in summer and autumn (20.23 ± 7.14 ng/mL; 8.02% and 19.10 ± 6.97 ng/mL; 6.61% [p < 0.01], respectively); and in older individuals (0-6 years: 28.29 ± 13.13 ng/mL vs. >60 years: 14.88 ± 8.39 ng/mL; p < 0.01). Relatively higher vitamin D levels were observed in individuals of Yi, Zhuang, Hani, Dai, Miao and Lisu minorities and lower levels in individuals of Hui and Zang minorities compared with those of the Han nationality (p < 0.01). The mean sunlight duration, mean air temperature, maximum ultraviolet value and latitude were significantly correlated with vitamin D levels (r = -0.53, 0.60, 0.31, -0.68, respectively; p < 0.05). These results suggest that vitamin D status is influenced by sex, age, minority, latitude and some meteorological factors in areas with high and low altitudes. Hence, new public health policies, such as advice on sunshine exposure, food fortification and nutrition education, as well as the implementation of vitamin D supplementation programmes must be considered to alleviate vitamin D deficiency in Yunnan province, Southwest China.

维生素D缺乏症在世界各地的不同人群和地区普遍存在,已成为一个全球性的健康问题。到目前为止,中国西南部云南省人群的维生素D状况尚未得到评估。因此,在本研究中,我们根据中国低纬度、高海拔和多种族地区云南省个体的血清25-羟基维生素D(25(OH)D)浓度来评估维生素D状况。使用实验室信息系统对2012年10月至2017年12月的25(OH)D浓度数据进行了回顾性收集和评估 950名医院参与者(年龄1岁 第96天 年;女性,73.74%)。使用化学发光免疫测定法评估25(OH)D的血清浓度。分析按性别、年龄、采样季节、检测年份、少数民族、居住区、纬度、海拔和气象因素进行分层。维生素D状况分类如下:严重缺乏:60 年份:14.88 ± 8.39 ng/mL;p
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引用次数: 0
Understanding nutrition students' knowledge, perceived barriers and their views on the future role of nutritionists regarding sustainable diets. 了解营养专业学生的知识、感知障碍以及他们对营养学家在可持续饮食方面未来角色的看法。
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-12-01 Epub Date: 2023-11-10 DOI: 10.1111/nbu.12649
Cathrine Baungaard, Katie E Lane, Lucinda Richardson

Nutrition professionals are important stakeholders in sustainable food systems with skills to promote the connection between health, food production, environment, culture and economics. Higher education institutions are increasingly recognising the importance of teaching about sustainability, yet there exists a gap in the literature detailing the awareness of sustainability issues by nutrition students. This study aimed to ascertain the level of knowledge of sustainable diets (SDs), the perceived barriers to their adoption in their own diets, students' experience of university-based teaching about SDs and their views on the future role of the nutrition profession in relation to SD amongst nutrition students on Association for Nutrition (AfN)-accredited degrees. The study assessed environmental and sustainable food literacy (SFL) through an online questionnaire and explored the issues in more detail in virtual or face-to-face interviews in 2019. Quantitative data were analysed using descriptive statistics (Kruskal-Wallis, Jonckheere-Terpstra, independent t-test, Spearman, Pearson Correlations). Qualitative data were analysed using the Braun and Clark (2006) six-step approach to thematic analysis. The questionnaire responses (n = 51) represented 17 AfN-accredited undergraduate courses (35% of AfN-accredited universities in 2019). The majority (76%) of students had received an introduction, partaken in a module or received teaching on SDs throughout their whole degree. Students were predominantly environmentally literate, yet had a fragmented understanding of SDs, focusing on the environmental aspects of SDs. There was no correlation between SFL and reported sustainability content of university courses, highlighting a need for more effective teaching on sustainability topics. Additionally, no relationship between self-reported diet intake and SFL was found. Students identified a lack of knowledge and education as barriers preventing them from adopting sustainable practices in the present and future. To integrate sustainability into their future practice more consistently and effectively, nutrition students require more structured, holistic sustainability education and knowledge.

营养专业人员是可持续粮食系统的重要利益相关者,具有促进健康、粮食生产、环境、文化和经济之间联系的技能。高等教育机构越来越认识到可持续性教学的重要性,但在详细描述营养学生对可持续性问题的认识的文献中存在空白。本研究旨在确定营养协会(AfN)认证学位的营养专业学生对可持续饮食的知识水平、在自己的饮食中采用可持续饮食的障碍、学生在大学教授可持续饮食的经验以及他们对营养专业未来在可持续饮食中的作用的看法。该研究通过在线问卷评估了环境和可持续食品扫盲(SFL),并在2019年的虚拟或面对面采访中更详细地探讨了这些问题。定量数据采用描述性统计学(Kruskal-Wallis、Jonckheere Terpstra、独立t检验、Spearman、Pearson相关)进行分析。定性数据采用Braun和Clark(2006)六步专题分析法进行分析。问卷答复(n = 51)代表了17所AfN认证的本科课程(2019年占AfN认证大学的35%)。大多数(76%)的学生在整个学位期间都接受过介绍、参加过模块或接受过可持续发展教育。学生主要具有环境知识,但对可持续发展的理解不完整,专注于可持续发展的环境方面。SFL与报告的大学课程可持续性内容之间没有相关性,这突出表明需要就可持续性主题进行更有效的教学。此外,没有发现自我报告的饮食摄入量和SFL之间的关系。学生们认为,缺乏知识和教育是阻碍他们在现在和未来采用可持续做法的障碍。为了更一致、更有效地将可持续性融入他们未来的实践,营养专业的学生需要更结构化、更全面的可持续性教育和知识。
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引用次数: 0
British Nutrition Foundation Notices 英国营养基金会通知
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-11-20 DOI: 10.1111/nbu.12650
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引用次数: 0
CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake. CD36基因多态性和唾液信号与油酸敏感性和饮食脂肪摄入有关。
IF 3.3 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2023-09-01 Epub Date: 2023-08-03 DOI: 10.1111/nbu.12633
Karthi Muthuswamy, Deepankumar Shanmugamprema, Gowtham Subramanian, Vinithra Ponnusamy, Keerthana Vasanthakumar, Vasanth Krishnan, Praveen Raj Palanivelu, Senthilkumar Rajasekaran, Selvakumar Subramaniam

There is a lack of research on the combined effects of genetic variations (specifically CD36 SNPs-rs1761667 and rs1527483), dietary food habits (vegetarian or not), and the salivary environment on obesity and taste sensitivity, especially in the Indian population. The current study aims to better understand the relationship between impaired taste perception, fat consumption, higher BMI and obesity development by examining the combined association between CD36 SNPs, oleic acid (OA) detection threshold, and food habits among Indian participants. Furthermore, the relationship between oral fatty acid (FAs) sensitivity and taste physiology factors linked to inflammation and salivary proteins was considered. Participants with the minor allele (AA/AG) of CD36 (in both rs1527483 and rs1761667) consumed more fat, particularly saturated FAs (p = 0.0351). Salivary lipopolysaccharide, which causes inflammation, was significantly greater in non-vegetarians with a higher BMI (p < 0.05), and it exhibited a negative correlation (r = -0.232 and p < 0.05) with Ki67 gene expression, a marker for taste progenitor cells. A positive correlation (r = 0.474, p = 0.04) between TLR4 mRNA levels and the OA detection threshold was also observed. Participants with BMI > 25 kg/m2 had substantially higher TNF-α and IL-6 receptor mRNA expression levels, but there were no significant differences between the vegetarian and non-vegetarian groups. However, salivary CA-VI, which has a buffering capability on the oral environment, was lower in non-vegetarian adults with BMI >25. Thus, it was shown that non-vegetarians with overweight and obesity in India were in at-risk groups for the CD36 SNP (AA/AG at rs1761667 and rs1527483) and had higher levels of inflammatory markers, which exacerbated alterations in food behaviour and physiological changes, indicating their relevance in the development of obesity.

缺乏对遗传变异(特别是CD36 SNPs-rs1761667和rs1527483)、饮食习惯(是否素食)和唾液环境对肥胖和味觉敏感的综合影响的研究,尤其是在印度人群中。目前的研究旨在通过检测印度参与者中CD36 SNPs、油酸(OA)检测阈值和饮食习惯之间的联合关系,更好地了解味觉受损、脂肪消耗、较高BMI和肥胖发展之间的关系。此外,还考虑了口腔脂肪酸(FA)敏感性与炎症和唾液蛋白相关的味觉生理因素之间的关系。具有CD36小等位基因(AA/AG)的参与者(在rs1527483和rs1761667中)消耗了更多的脂肪,尤其是饱和脂肪酸(p = 引起炎症的唾液脂多糖在BMI较高的非素食者中显著增加(p  25 kg/m2具有显著较高的TNF-α和IL-6受体mRNA表达水平,但素食组和非素食组之间没有显著差异。然而,唾液中对口腔环境具有缓冲能力的CA-VI在患有BMI的非素食成年人中较低 >25.因此,研究表明,印度超重和肥胖的非素食者属于CD36 SNP的高危人群(AA/AG为rs1761667和rs1527483),并且具有较高水平的炎症标志物,这加剧了食物行为和生理变化的改变,表明它们与肥胖的发展有关。
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引用次数: 0
期刊
Nutrition Bulletin
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