Nano-detergents formulated by incorporating nanomaterials into conventional detergent have drawn great attention due to the superior cleaning performance and favorable physicochemical properties. However, further analyses of potential risks and environmental impacts are necessary. Grounded in the principles of Safe and Sustainable by Design (SSbD), this study combined life cycle assessment (LCA) with scenario analysis to evaluate environmental impacts of two Fe3O4-based nano-detergents (Fe3O4-NDGs) acorssed four stages: raw materials and energy, production, use and discharge. Then, four scenarios were established to explore potential mitigation pathways: use efficiency (S1), energy structure (S2), formulation optimization (S3) and nano-detergent recycling (S4). Baseline results showed that marine aquatic ecotoxicity potential (MAEP), freshwater ecotoxicity potential (FETP), abiotic depletion of fossil fuels (ADFP), and global warming potential (GWP) were the dominant environmental impact indicators. The two Fe3O4-NDGs environmental impacts were primarily concentrated in production stage. For NDG-1, the production stage respectively contributed 97.50 %, 93.69 %, and 75.37 % to FETP, PHO, and HTTP. GWP was 0.726 kg CO2 eq. For NDG-2, this stage respectively contributed to FETP, PHO, and HTP reached 97.76 %, 94.32 %, and 75.97 %. GWP was 0.628 kg CO2 eq. The key influencing factors during production were the use of chemical materials and electricity. Scenario analysis revealed that NDG-2 was more sensitive to S1, with environmental impact indicators decreasing by 22.06 %. S2 performed mitigation for two Fe3O4-NDGs. S3 reducted FETP and PHO of NDG-1 by more than 40 %. Based on the results, to minize enviromental impacts, it was recommended that future research and development should prioritize the use of green alternatives of raw materials during the production. Cleaner energy could mitigate the environmental impacts of nano-detergents effectively. This study provides the scientific evidence for sustainable development of environmental friendly cleaning products.
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