Robin Sequence is a complex congenital condition defined by the triad of micrognathia, glossoptosis, and upper airway obstruction. This comprehensive review aims to synthesize current knowledge regarding the etiology, diverse clinical presentations, diagnostic challenges, and multidisciplinary management strategies for Robin Sequence, with a specific focus on implications relevant to orthodontic and craniofacial care. The challenge of diagnosing micrognathia and addressing the heterogeneity of associated conditions, including syndromic, isolated, and non-syndromic forms, has been approached. Diagnostic modalities, ranging from prenatal ultrasonography to polysomnography and endoscopic airway evaluation, are explored in detail, with an emphasis on their roles in assessing the severity and localization of airway compromise. The review provides a comprehensive analysis of various treatment approaches for airway obstruction and dysphagia, including prone positioning, nasopharyngeal intubation, glossopexy, mandibular distraction osteogenesis, and tracheostomy, comparing their efficacy, indications, and potential complications. Special attention is given to the impact of cleft palate, a common associated feature, on feeding and respiratory function, and its surgical repair. Understanding the nuanced interplay of anatomical and functional factors in Robin Sequence is crucial for developing individualized and effective treatment protocols, ultimately improving long-term outcomes for affected individuals.
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